Photodynamic therapy (PDT) is a clinically approved, minimally invasive form of anticancer therapy. IT involves the administration of a photosensitizer, followed by irradiation with a light source leading to the generation of highly reactive oxygen species that kill tumor cells. Currently, PDT has two main limitations, namely it is not suitable for large or deeply embedded tumors and it is not suitable for the treatment of metastases. In this project, we aim to search for novel and more effective photosensitizers, that are able to induce immunogenic cell death of cancer cells, resulting in the establishment of anti-tumor immunity. We first focus on the treatment of melanoma, a neoplasm originating from the melanocytes of the epidermis. Although melanoma only corresponds to 4% of skin-related cancers, it is the causal agent for 80% of deaths resulting from dermatological cancer. There is an especially large unmet clinical need for the development of new therapies to treat melanoma in advanced stages with systemic dispersion.