Project

MEMCLIP: A comprehensive chemical-biology approach to understand the bioactivity of Pseudomonas cyclic lipopeptides on eukaryotic membranes

Acronym

MemCLiP

Code

01G02819

Duration

01 January 2019 → 31 December 2022

Funding

Regional and community funding: Special Research Fund

Promotor-spokesperson

Monica Höfte

Research disciplines

Natural sciences
- Structural analysis
- Bio-organic chemistry
- Analytical biochemistry
- Lipidomics
Medical and health sciences
- Lipids
- Lipids
- Regulation of metabolism

Keywords

Lipopeptides fluorescent labeling and tracking solid phase synthesis structure analysis plant cell suspension cultures innate immunity in plants bioactivity and control anti tumor cell activity

Project description

The activity of cyclic lipopeptides, produced by Pseudomonas bacteria and chemically synthesized analogues will be tested in a standardized way on human (healthy and cancer) cells, plant cell suspensions and fungal cells. Using a combination of biological and (physico-)chemical methods we will test the hypothesis that in all these eukaryotic cells, these lipopeptides act on lipids in the cell membranes.