We employ integrative structural biology to study the structure and mechanism of proteins and protein complexes pivotal to immunity, inflammation, and cancer. Over the years we have taken a leading role in the elucidation of cytokine-receptor complexes and in the development of protein-based modulators (antagonists/agonists) against complexes of biomedical importance. The cornerstone of our research philosophy lies in a rigorous hypothesis-driven interrogation of the proteins and protein assemblies under study, and is firmly nested in collaborations with leading academic research groups and industrial partners,  including extensive activities in translational science.

We are actively investigating the following research areas:

• Protein signaling assemblies in immunity, inflammation, cancer.

• Structure-based drug design against protein-protein interactions.

• Protein engineering and protein design towards modulators of cytokine signaling.

• In vivo protein crystals and protein phase transitions in immunity, inflammation, and cancer.