Achilles tendinopathy (AT) is the most common tendon injury affecting individuals across various athletic and non-athletic populations, characterized by pain, stiffness, and impaired function of the Achilles tendon. Despite the prevalence of this condition, current rehabilitation strategies often yield suboptimal outcomes. Blood flow restriction (BFR) training has emerged as a promising rehabilitation modality, involving the application of pneumatic cuffs to induce hypoxia during exercise, thereby inducing beneficial physiological adaptations at reduced training loads. The study will utilize a randomized controlled trial design, with participants allocated to either a BFR rehabilitation group, a sham rehabilitation group or a conventional rehabilitation group (control). A mixed-methods approach will be employed, integrating quantitative assessments of tendon morphology and blood biomarkers related to tendon healing, functional tests and qualitative analysis of patient disability, experiences and perceptions. Through this research, we aim to provide novel insights into the potential of BFR training as an effective and feasible rehabilitation intervention for AT. Findings from this study have the potential to elucidate underlying mechanisms of tendon regeneration and contribute to the optimization of rehabilitation strategies for individuals with AT, ultimately improving patient outcomes and quality of life.