Project

T-cell plasticity in chronic inflammatory airway diseases

Code
3G064210
Duration
01 January 2010 → 31 December 2015
Funding
Research Foundation - Flanders (FWO)
Research disciplines
  • Medical and health sciences
    • Immunology
    • Otorhinolaryngology
    • Immunology
    • Otorhinolaryngology
    • Speech, language and hearing sciences
    • Immunology
    • Otorhinolaryngology
Keywords
CRS T regular cells inflammation
 
Project description

In this study, T cell plasticity and survival and the role of different damage-associated molecular patterns, prostaglandins, and bacterial superantigens in chronic rhinosinutisis will be studied. The role of the specific mucosal milieu on T cell plasticity will be analyzed in vitro, in vivo in Rag2-/-yc-/-knockout mice transplanted with human inflamed mucosa, and ex vivo in human nasal mucosal tissue.