Code
3F003407
Duration
01 October 2007 → 30 September 2010
Funding
Regional and community funding: Special Research Fund, Research Foundation - Flanders (FWO)
Promotor
Fellow
Research disciplines
-
Natural sciences
- Organic chemistry
-
Medical and health sciences
- Biomarker discovery and evaluation
- Drug discovery and development
- Medicinal products
- Pharmaceutics
- Pharmacognosy and phytochemistry
- Pharmacology
- Pharmacotherapy
- Toxicology and toxinology
- Other pharmaceutical sciences
Keywords
NKT cells
synthese
KRN 7000
Project description
Synthesis of alfa-galactosylceramide (KRN 7000) analogues with potential induction of a polarised cytokine respons (Th1 or Th2) by NKT cells. The proposed modifications intend an improved bindingafffinity with the CD1d protein. This should result in a bias towards a Th1 respons.