The overarching aim of the lab is to improve our understanding of the working mechanisms of mood and anxiety disorders, integrating findings from clinical, cognitive, behavioral and neurobiological research, in a life-span perspective. Therefore, we use affective modifications of experimental psychology paradigms, as well as behavioral measures such as Eye Movement Registration. Moreover these paradigms are combined with neuroimaging techniques, psychophysiological measures and other physiologicalindicators such as pupil dilation, skin conductance, saliva cortisol and heart rate variability. To investigate causal mechanisms, methods that allow the experimental modification of information-processing biases are used, such as cognitive training and neurostimulation. Based on this fundamental neurocognitive research, innovative interventions are developed, based on strategies of emotion regulation and on a combination of neurostimulation and cognitive training.