Collaborative Research Unit

Laboratory of Pharmacology and Toxicology

Acronym
LPT
Co-ordinator
Other information
Research disciplines
  • Natural sciences
    • Analytical separation and detection techniques
    • Analytical spectrometry
  • Medical and health sciences
    • Analytical toxicology
  • Agricultural and food sciences
    • Veterinary pharmacology and toxicology
    • Veterinary public health and food safety
    • Agricultural, veterinary and food sciences not elsewhere classified
Description
The main research mission of the Laboratory of Pharmacology and Toxicology of Ghent University (Prof. dr. S. Croubels, Prof. dr. M. Devreese) consists of generating and communicating insights in in vivo ADME processes (absorption, distribution, metabolisation and excretion) and PK/PD modeling of human and veterinary drugs and toxins in a variety of animal species. The Laboratory is OECD GLP (Good Laboratory Practice) compliant for the conduct of in vivo ADME trials, pharmacokinetic modeling, safety studies, and bio-analysis of human and veterinary drugs. The Laboratory has over 20 years of experience in the development of analytical methodologies for the detection and quantification of xenobiotics (mainly drugs, mycotoxins and their metabolites) in different biological samples such as plasma and tissues, using (UHP)LC-MS/MS and HR-LC-MS, and in pharmacokinetic (PK) and toxicokinetic (TK) modeling of these compounds. The laboratory has 4 (UHP)LC-MS/MS instruments, 1 UHPLC-UV instrument and access to 3 HR-LC-MS