A cryostat is a specialized instrument primarily used in histology and biomedical research to cut thin sections from frozen biological samples (cryosections) for microscopic examination. In the Histocore facility, these cryosections are mainly utilized for various immunohistochemical stainings. Particularly, immunofluorescent stainings are applied to localize antigens (proteins, lipids, etc.) in the tissue using antibodies. Localizing antigens in sections is crucial in basic research and provides important insights into the localization of the studied molecules in disease models versus control models.

The Cryostat NX70 provides separate temperature control for the blade and the specimen, necessary for optimal cutting of the various tissue types used. This device also offers the capability of automated sectioning, which further standardizes and simplifies the cutting process. A vacuum system ensures that the cryosections are evenly stretched and facilitates easy removal of excess material afterward.