When kidney function declines, the blood is not purified as effectively and waste products accumulate in the blood. This accumulation of waste products makes the patient ill.

Chronic kidney disease usually confronts patients and their families with a number of limitations. The treatment requires major adjustments to daily life. It is also important to be aware of the psychological impact. In addition, chronically ill people are often confronted with significant changes in their professional lives. Since work is a determining factor in people's self-image, many patients want to remain professionally active for as long as possible. This requires a great deal of flexibility, both from the employer and the patient. Sometimes the disease and treatment prevent the patient from continuing to work permanently.