Research Explorer

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Researcher

Zifu Zhong

Publications & Research Data

Awards & Distinctions

36 Results

2025

A f entanyl hapten-displaying lipid nanoparticle vaccine that non-covalently encapsulates a TLR7/8 agonist and T-helper epitope induces protective anti-fentanyl immunity

Zifu ZhongMarie DeventerYong ChenStijn VanheeInés LammensKim DeswarteYi HuangTingting YeHaixiu WangLutz Nuhn et al.

A1 Journal Article in ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A genetically encoded endogenous antibody recruitment strategy for innate immune-mediated killing of cancer cells

Justine AelvoetZifu ZhongClaudia Mariela Brenis GómezHelena Catharine AegerterBenoit LouageBart LambrechtBruno De GeestMartijn Schuijs

A1 Journal Article in ADVANCED MATERIALS

Combinatorial synthesis and evaluation of trialkyl galloyl amidoamine ionizable lipids for mRNA formulation

Bianka GolbaIrene De FranceschiZifu ZhongMartijn SchuijsClaudia Mariela Brenis GómezHeleen LauwersBenoit LouageIasona SheshiNezha BadiBruno De Geest et al.

A1 Journal Article in JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enhancing anti-tumor immunity through intratumoral combination therapy with amphiphilic conjugates of oxaliplatin and imidazoquinoline TLR7/8 agonist

Hanne VerschuereSabah KasmiLutz NuhnSènan Mickaël D'AlmeidaQiwen ZhuZifu ZhongSandy Adjemian CataniBenoit LouageJana De VriezeHaijun Yu et al.

A1 Journal Article in RSC ADVANCES

The efficacy of self-amplifying RNA vaccines against H5N1 influenza and the impact of pre-existing immunity against the replicase of self-amplifying RNA

Xiaole CuiNiek SandersZifu Zhong

2024

Amplification of protein expression by self-amplifying mRNA delivered in lipid nanoparticles containing a β-aminoester ionizable lipid correlates with reduced innate immune activation

Emily De LombaerdeXiaole CuiYong ChenZifu ZhongJulie DeckersGiulia MencarelliLisa OpsomerHaixiu WangJamie De BaereStefan Lienenklaus et al.

A1 Journal Article in ACS NANO

CO-DELIVERY of glutamic acid-extended peptide antigen and imidazoquinoline TLR7/8 agonist via ionizable lipid nanoparticles induces protective anti-tumor immunity

Tingting YeZifu ZhongFederica CappellessoKim DeswarteYong ChenHeleen LauwersEmily De LombaerdeMark GontsarikStefan LienenklausDorien Van Lysebetten et al.

A1 Journal Article in BIOMATERIALS

Combinatorial screening of biscarbamate ionizable lipids identifies a low reactogenicity lipid for lipid nanoparticle mRNA delivery

Emily De LombaerdeYong ChenTingting YeJulie DeckersGiulia MencarelliKim DeswarteHeleen LauwersRuben De CoenSabah KasmiSanne Bevers et al.

A1 Journal Article in ADVANCED FUNCTIONAL MATERIALS

HER2 nanobody-poly(rhamnose) conjugates efficiently recruit anti-rhamnose antibodies from serum to the surface of HER2-expressing cells

Weiwei MuYong ChenZifu ZhongBenoit LouageHeleen LauwersNick DevoogdtJurgen HaustraeteBruno De Geest

A1 Journal Article in CHEMISTRY OF MATERIALS

Immunogenicity and biodistribution of lipid nanoparticle formulated self-amplifying mRNA vaccines against H5 avian influenza

Xiaole CuiPieter VervaekeYa GaoLisa OpsomerQing SunJanne SnoeckBert DevriendtZifu ZhongNiek Sanders

A1 Journal Article in NPJ VACCINES

Lipid nanoparticle encapsulation empowers poly(I:C) to activate cytoplasmic RLRs and thereby increases its adjuvanticity

Alexander LamootSonia JangraGabriel LaghlaliPrajakta WarangLauren A. ChangSeok‐Chan ParkGagandeep SinghKim DeswarteZifu ZhongBenoit Louage et al.

A1 Journal Article in SMALL

PH-triggered, lymph node focused immunodrug release by polymeric 2-propionic-3-methyl-maleic anhydrides with cholesteryl end groups

Alina G. HeckCarolina Medina-MontanoZifu ZhongKim DeswarteKatharina EigenJudith StickdornJohannes KockelmannMaximilian SchergerNiek SandersStefan Lienenklaus et al.

A1 Journal Article in ADVANCED HEALTHCARE MATERIALS

2023

Design of fluorescent polymeric thermometers based on anthrapyrazolone functionalized oligo(ethylene glycol) methacrylates

S. SaravananAnashwara BabuRonald MerckxZifu ZhongMageshwari AnandanVenkatramaiah NutalapatiBruno De GeestRichard HoogenboomValentin-Victor JercaSamarendra Maji

A1 Journal Article in MATERIALS CHEMISTRY FRONTIERS

Lipid nanoparticle delivery alters the adjuvanticity of the TLR9 agonist CpG by innate immune activation in lymphoid tissue

Zifu ZhongYong ChenKim DeswarteHeleen LauwersEmily De LombaerdeXiaole CuiSimon Van HerckTingting YeMark GontsarikStefan Lienenklaus et al.

A1 Journal Article in ADVANCED HEALTHCARE MATERIALS

Successful batch and continuous lyophilization of mRNA LNP formulations depend on cryoprotectants and ionizable lipids

Alexander LamootJoris LammensEmily De LombaerdeZifu ZhongMark GontsarikYong ChenThomas De BeerBruno De Geest

A1 Journal Article in BIOMATERIALS SCIENCE

Visible light conjugation with triazolinediones as a route to degradable poly(ethylene glycol)-lipids for mRNA lipid nanoparticle formulation

Bianka GolbaMatthieu SoeteZifu ZhongNiek SandersFilip Du PrezHannes HouckBruno De Geest

A1 Journal Article in ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

2021

Corticosteroids and cellulose purification improve, respectively, the in vivo translation and vaccination efficacy of sa-mRNAs

Zifu ZhongSéan Mc CaffertyLisa OpsomerHaixiu WangHanne HuysmansJoyca De TemmermanStefan LienenklausJoão Portela CataniFrancis CombesNiek Sanders

A1 Journal Article in MOLECULAR THERAPY

Corticosteroids and mRNA vaccines : a word of caution

Zifu ZhongFrancis CombesNiek Sanders

A1 Journal Article in MOLECULAR THERAPY

Lipid-polyglutamate nanoparticle vaccine platform

Dorien Van LysebettenAlessio MalfantiKim DeswarteKaloian KoynovBianka GolbaTingting YeZifu ZhongSabah KasmiAlexander LamootYong Chen et al.

A1 Journal Article in ACS APPLIED MATERIALS & INTERFACES

Squaric ester-based, pH-degradable nanogels : modular nanocarriers for safe, systemic administration of toll-like receptor 7/8 agonistic immune modulators

Anne HuppertsbergLeonard KapsZifu ZhongSascha SchmittJudith StickdornKim DeswarteFrancis CombesChristian CzyschJana De VriezeSabah Kasmi et al.

A1 Journal Article in JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Sterilizing immunity against SARS‐CoV‐2 infection in mice by a single‐shot and lipid amphiphile imidazoquinoline TLR7/8 agonist‐adjuvanted recombinant spike protein vaccine**

Sonia JangraJana De VriezeAngela ChoiRaveen RathnasingheGabriel LaghlaliAnnemiek UvynSimon Van HerckLutz NuhnKim DeswarteZifu Zhong et al.

A1 Journal Article in ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

2020

Current status of COVID-19 (pre)clinical vaccine development

Tingting YeZifu ZhongAdolfo Garcia-SastreMichael SchotsaertBruno De Geest

A1 Journal Article in ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Development of a self-replicating mRNA vaccine against Zika virus

Zifu ZhongNiek Sanders

Imidazoquinoline-conjugated degradable coacervate conjugate for local cancer immunotherapy

Hui LiSimon Van HerckYongjun LiuYanyun HaoXiaochu DingLutz NuhnZifu ZhongFrancis CombesNiek SandersStefan Lienenklaus et al.

A1 Journal Article in ACS BIOMATERIALS SCIENCE & ENGINEERING

Poly(2-ethyl-2-oxazoline) conjugates with salicylic acid via degradable modular ester linkages

Yann BernhardOndrej SedlacekJoachim Van GuyseJohan BenderZifu ZhongBruno De GeestRichard Hoogenboom

A1 Journal Article in BIOMACROMOLECULES

Potent and prolonged innate immune activation by enzyme-responsive imidazoquinoline TLR7/8 agonist prodrug vesicles

Bi WangSimon Van HerckYong ChenXiangyang BaiZifu ZhongKim DeswarteBart LambrechtNiek SandersStefan LienenklausHans W. Scheeren et al.

A1 Journal Article in JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Sterilizing immunity against SARS-CoV-2 infection in mice by a single-shot and modified imidazoquinoline TLR7/8 agonist-adjuvanted recombinant spike protein vaccine

Sonia JangraJana De VriezeAngela ChoiRaveen RathnasingheGabriel LaghlaliAnnemiek UvynSimon Van HerckLutz NuhnKim DeswarteZifu Zhong et al.

The opposing effect of type I IFN on the T cell response by non-modified mRNA-lipoplex vaccines Is determined by the route of administration

Lien Van HoeckeKenny RooseMarlies BallegeerZifu ZhongNiek SandersStefaan De KokerXavier SaelensSandra Van Lint

A1 Journal Article in MOLECULAR THERAPY-NUCLEIC ACIDS

2019

Expression kinetics and innate immune response after electroporation and LNP-mediated delivery of a self-amplifying mRNA in the skin

Hanne HuysmansZifu ZhongJoyca De TemmermanBarbara L MuiYing K TamSéan Mc CaffertyArlieke GitselsDaisy VanrompayNiek Sanders

A1 Journal Article in MOLECULAR THERAPY-NUCLEIC ACIDS

Heat-stable enterotoxins of enterotoxigenic Escherichia coli and their impact on host immunity

Haixiu WangZifu ZhongYu LuoEric CoxBert Devriendt

A1 Journal Article in TOXINS

Immunogenicity and protection efficacy of a naked self-replicating mRNA-based Zika virus vaccine

Zifu ZhongJoão Paulo Portela CataniSéan Mc CaffertyLiesbeth CouckWim Van Den BroeckNina GorléRoosmarijn VandenbrouckeBert DevriendtSebastian UlbertLieselotte Cnops et al.

A1 Journal Article in VACCINES

Improving the repeatability and efficacy of intradermal electroporated self-replicating mRNA

Hanne HuysmansJoyca De TemmermanZifu ZhongSéan Mc CaffertyFrancis CombesFreddy HaesebrouckNiek Sanders

A1 Journal Article in MOLECULAR THERAPY-NUCLEIC ACIDS

Potent Lymphatic Translocation and Spatial Control Over Innate Immune Activation by Polymer-Lipid Amphiphile Conjugates of Small-Molecule TLR7/8 Agonists

Jana De VriezeBenoit LouageKim DeswarteZifu ZhongRuben De CoenSimon Van HerckLutz NuhnCamilla Kaas FrichAlexander N ZelikinStefan Lienenklaus et al.

A1 Journal Article in ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

2018

Lymph-node-targeted immune activation by engineered block copolymer amphiphiles-TLR7/8 agonist conjugates

Simon Van HerckKim DeswarteLutz NuhnZifu ZhongJoão Portela CataniYupeng LiNiek SandersStefan LienenklausStefaan De KokerBart Lambrecht et al.

A1 Journal Article in JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

mRNA therapeutics deliver a hopeful message

Zifu ZhongSéan Mc CaffertyFrancis CombesHanne HuysmansJoyca De TemmermanArlieke GitselsDaisy VanrompayJoão Portela CataniNiek Sanders

A1 Journal Article in NANO TODAY

Nanoparticle-conjugate TLR7/8 agonist localized immunotherapy provokes safe antitumoral responses

Lutz NuhnStefaan De KokerSandra Van LintZifu ZhongJoão Portela CataniFrancis CombesKim DeswarteYupeng LiBart LambrechtStefan Lienenklaus et al.

A1 Journal Article in ADVANCED MATERIALS