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Researcher
Zifu Zhong
Profile
Projects
Publications
Activities
Awards & Distinctions
28
Results
2024
Combinatorial screening of biscarbamate ionizable lipids identifies a low reactogenicity lipid for lipid nanoparticle mRNA delivery
Emily De Lombaerde
Yong Chen
Tingting Ye
Julie Deckers
Giulia Mencarelli
Kim Deswarte
Heleen Lauwers
Ruben De Coen
Sabah Kasmi
Sanne Bevers
et al.
A1
Journal Article
in
ADVANCED FUNCTIONAL MATERIALS
2024
Immunogenicity and biodistribution of lipid nanoparticle formulated self-amplifying mRNA vaccines against H5 avian influenza
Xiaole Cui
Pieter Vervaeke
Ya Gao
Lisa Opsomer
Qing Sun
Janne Snoeck
Bert Devriendt
Zifu Zhong
Niek Sanders
A1
Journal Article
in
NPJ VACCINES
2024
Lipid nanoparticle encapsulation empowers poly(I:C) to activate cytoplasmic RLRs and thereby increases its adjuvanticity
Alexander Lamoot
Sonia Jangra
Gabriel Laghlali
Prajakta Warang
Lauren A. Chang
Seok‐Chan Park
Gagandeep Singh
Kim Deswarte
Zifu Zhong
Benoit Louage
et al.
A1
Journal Article
in
SMALL
2024
PH-triggered, lymph node focused immunodrug release by polymeric 2-propionic-3-methyl-maleic anhydrides with cholesteryl end groups
Alina G. Heck
Carolina Medina-Montano
Zifu Zhong
Kim Deswarte
Katharina Eigen
Judith Stickdorn
Johannes Kockelmann
Maximilian Scherger
Niek Sanders
Stefan Lienenklaus
et al.
A1
Journal Article
in
ADVANCED HEALTHCARE MATERIALS
2024
2023
Design of fluorescent polymeric thermometers based on anthrapyrazolone functionalized oligo(ethylene glycol) methacrylates
S. Saravanan
Anashwara Babu
Ronald Merckx
Zifu Zhong
Mageshwari Anandan
Venkatramaiah Nutalapati
Bruno De Geest
Richard Hoogenboom
Valentin-Victor Jerca
Samarendra Maji
A1
Journal Article
in
MATERIALS CHEMISTRY FRONTIERS
2023
Lipid nanoparticle delivery alters the adjuvanticity of the TLR9 agonist CpG by innate immune activation in lymphoid tissue
Zifu Zhong
Yong Chen
Kim Deswarte
Heleen Lauwers
Emily De Lombaerde
Xiaole Cui
Simon Van Herck
Tingting Ye
Mark Gontsarik
Stefan Lienenklaus
et al.
A1
Journal Article
in
ADVANCED HEALTHCARE MATERIALS
2023
Successful batch and continuous lyophilization of mRNA LNP formulations depend on cryoprotectants and ionizable lipids
Alexander Lamoot
Joris Lammens
Emily De Lombaerde
Zifu Zhong
Mark Gontsarik
Yong Chen
Thomas De Beer
Bruno De Geest
A1
Journal Article
in
BIOMATERIALS SCIENCE
2023
Visible light conjugation with triazolinediones as a route to degradable poly(ethylene glycol)-lipids for mRNA lipid nanoparticle formulation
Bianka Golba
Matthieu Soete
Zifu Zhong
Niek Sanders
Filip Du Prez
Hannes Houck
Bruno De Geest
A1
Journal Article
in
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
2023
2021
Corticosteroids and cellulose purification improve, respectively, the in vivo translation and vaccination efficacy of sa-mRNAs
Zifu Zhong
Séan Mc Cafferty
Lisa Opsomer
Haixiu Wang
Hanne Huysmans
Joyca De Temmerman
Stefan Lienenklaus
João Portela Catani
Francis Combes
Niek Sanders
A1
Journal Article
in
MOLECULAR THERAPY
2021
Corticosteroids and mRNA vaccines : a word of caution
Zifu Zhong
Francis Combes
Niek Sanders
A1
Journal Article
in
MOLECULAR THERAPY
2021
Lipid-polyglutamate nanoparticle vaccine platform
Dorien Van Lysebetten
Alessio Malfanti
Kim Deswarte
Kaloian Koynov
Bianka Golba
Tingting Ye
Zifu Zhong
Sabah Kasmi
Alexander Lamoot
Yong Chen
et al.
A1
Journal Article
in
ACS APPLIED MATERIALS & INTERFACES
2021
Squaric ester-based, pH-degradable nanogels : modular nanocarriers for safe, systemic administration of toll-like receptor 7/8 agonistic immune modulators
Anne Huppertsberg
Leonard Kaps
Zifu Zhong
Sascha Schmitt
Judith Stickdorn
Kim Deswarte
Francis Combes
Christian Czysch
Jana De Vrieze
Sabah Kasmi
et al.
A1
Journal Article
in
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
2021
Sterilizing immunity against SARS‐CoV‐2 infection in mice by a single‐shot and lipid amphiphile imidazoquinoline TLR7/8 agonist‐adjuvanted recombinant spike protein vaccine**
Sonia Jangra
Jana De Vrieze
Angela Choi
Raveen Rathnasinghe
Gabriel Laghlali
Annemiek Uvyn
Simon Van Herck
Lutz Nuhn
Kim Deswarte
Zifu Zhong
et al.
A1
Journal Article
in
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
2021
2020
Current status of COVID-19 (pre)clinical vaccine development
Tingting Ye
Zifu Zhong
Adolfo Garcia-Sastre
Michael Schotsaert
Bruno De Geest
A1
Journal Article
in
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
2020
Development of a self-replicating mRNA vaccine against Zika virus
Zifu Zhong
Niek Sanders
Dissertation
2020
Imidazoquinoline-conjugated degradable coacervate conjugate for local cancer immunotherapy
Hui Li
Simon Van Herck
Yongjun Liu
Yanyun Hao
Xiaochu Ding
Lutz Nuhn
Zifu Zhong
Francis Combes
Niek Sanders
Stefan Lienenklaus
et al.
A1
Journal Article
in
ACS BIOMATERIALS SCIENCE & ENGINEERING
2020
Poly(2-ethyl-2-oxazoline) conjugates with salicylic acid via degradable modular ester linkages
Yann Bernhard
Ondrej Sedlacek
Joachim Van Guyse
Johan Bender
Zifu Zhong
Bruno De Geest
Richard Hoogenboom
A1
Journal Article
in
BIOMACROMOLECULES
2020
Potent and prolonged innate immune activation by enzyme-responsive imidazoquinoline TLR7/8 agonist prodrug vesicles
Bi Wang
Simon Van Herck
Yong Chen
Xiangyang Bai
Zifu Zhong
Kim Deswarte
Bart Lambrecht
Niek Sanders
Stefan Lienenklaus
Hans W. Scheeren
et al.
A1
Journal Article
in
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
2020
Sterilizing immunity against SARS-CoV-2 infection in mice by a single-shot and modified imidazoquinoline TLR7/8 agonist-adjuvanted recombinant spike protein vaccine
Sonia Jangra
Jana De Vrieze
Angela Choi
Raveen Rathnasinghe
Gabriel Laghlali
Annemiek Uvyn
Simon Van Herck
Lutz Nuhn
Kim Deswarte
Zifu Zhong
et al.
Preprint
2020
The opposing effect of type I IFN on the T cell response by non-modified mRNA-lipoplex vaccines Is determined by the route of administration
Lien Van Hoecke
Kenny Roose
Marlies Ballegeer
Zifu Zhong
Niek Sanders
Stefaan De Koker
Xavier Saelens
Sandra Van Lint
A1
Journal Article
in
MOLECULAR THERAPY-NUCLEIC ACIDS
2020
2019
Expression kinetics and innate immune response after electroporation and LNP-mediated delivery of a self-amplifying mRNA in the skin
Hanne Huysmans
Zifu Zhong
Joyca De Temmerman
Barbara L Mui
Ying K Tam
Séan Mc Cafferty
Arlieke Gitsels
Daisy Vanrompay
Niek Sanders
A1
Journal Article
in
MOLECULAR THERAPY-NUCLEIC ACIDS
2019
Heat-stable enterotoxins of enterotoxigenic Escherichia coli and their impact on host immunity
Haixiu Wang
Zifu Zhong
Yu Luo
Eric Cox
Bert Devriendt
A1
Journal Article
in
TOXINS
2019
Immunogenicity and protection efficacy of a naked self-replicating mRNA-based Zika virus vaccine
Zifu Zhong
João Paulo Portela Catani
Séan Mc Cafferty
Liesbeth Couck
Wim Van Den Broeck
Nina Gorlé
Roosmarijn Vandenbroucke
Bert Devriendt
Sebastian Ulbert
Lieselotte Cnops
et al.
A1
Journal Article
in
VACCINES
2019
Improving the repeatability and efficacy of intradermal electroporated self-replicating mRNA
Hanne Huysmans
Joyca De Temmerman
Zifu Zhong
Séan Mc Cafferty
Francis Combes
Freddy Haesebrouck
Niek Sanders
A1
Journal Article
in
MOLECULAR THERAPY-NUCLEIC ACIDS
2019
Potent Lymphatic Translocation and Spatial Control Over Innate Immune Activation by Polymer-Lipid Amphiphile Conjugates of Small-Molecule TLR7/8 Agonists
Jana De Vrieze
Benoit Louage
Kim Deswarte
Zifu Zhong
Ruben De Coen
Simon Van Herck
Lutz Nuhn
Camilla Kaas Frich
Alexander N Zelikin
Stefan Lienenklaus
et al.
A1
Journal Article
in
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
2019
2018
Lymph-node-targeted immune activation by engineered block copolymer amphiphiles-TLR7/8 agonist conjugates
Simon Van Herck
Kim Deswarte
Lutz Nuhn
Zifu Zhong
João Portela Catani
Yupeng Li
Niek Sanders
Stefan Lienenklaus
Stefaan De Koker
Bart Lambrecht
et al.
A1
Journal Article
in
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
2018
Nanoparticle-conjugate TLR7/8 agonist localized immunotherapy provokes safe antitumoral responses
Lutz Nuhn
Stefaan De Koker
Sandra Van Lint
Zifu Zhong
João Portela Catani
Francis Combes
Kim Deswarte
Yupeng Li
Bart Lambrecht
Stefan Lienenklaus
et al.
A1
Journal Article
in
ADVANCED MATERIALS
2018
mRNA therapeutics deliver a hopeful message
Zifu Zhong
Séan Mc Cafferty
Francis Combes
Hanne Huysmans
Joyca De Temmerman
Arlieke Gitsels
Daisy Vanrompay
João Portela Catani
Niek Sanders
A1
Journal Article
in
NANO TODAY
2018