Research Explorer

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Researcher

Yves-Paul Vandewynckel

31 Results

2018

Disbiome database : linking the microbiome to disease

Yorick JanssensJoachim NielandtAntoon BronselaerNathan DebunneFrederick VerbekeEvelien WynendaeleFilip Van ImmerseelYves-Paul VandewynckelGuy De TréBart De Spiegeleer

A1 Journal Article in BMC MICROBIOLOGY

The epigenetically regulated miR-494 associates with stem-cell phenotype and induces sorafenib resistance in hepatocellular carcinoma

Daniela PollutriClarissa PatriziSara MarinelliCatia GiovanniniElena TrombettaFerdinando A GiannoneMaurizio BaldassarreSantina QuartaYves-Paul VandewynckelAstrid VandierendonckHans Van VlierbergheLaura PorrettiMassimo NegriniLuigi BolondiLaura GramantieriFrancesca Fornari

A1 Journal Article in CELL DEATH & DISEASE

2017

Combination of tauroursodeoxycholic acid and N-acetylcysteine exceeds standard treatment for acetaminophen intoxication

Annelies ParidaensSarah RaevensIsabelle ColleEliene BogaertsYves-Paul VandewynckelXavier VerhelstAnne HoorensLeo A van GrunsvenHans Van VlierbergheAnja GeertsLindsey Devisscher

A1 Journal Article in LIVER INTERNATIONAL

Treatment of intestinal fibrosis in experimental inflammatory bowel disease by the pleiotropic actions of a local Rho kinase inhibitor

Tom HolvoetSarah DevrieseKarolien CastermansSandro BolandDirk LeysenYves-Paul VandewynckelLindsey DevisscherLien Van den BosscheSophie Van WeldenMelissa DullaersRoosmarijn VandenbrouckeRiet De RyckeKarel GeboesArnaud BourinOlivier DefertPieter HindryckxMartine De VosDebby Laukens

A1 Journal Article in GASTROENTEROLOGY

2016

Hepatocellular autophagy modulates the unfolded protein response and fasting-induced steatosis in mice

Wilhelmus J KwantenYves-Paul VandewynckelWim MartinetBenedicte Y De WinterPeter P MichielsenViviane O Van HoofAnn DriessenJean-Pierre TimmermansPierre BedossaHans Van VlierbergheSven M Francque

A1 Journal Article in AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Kinetics of pulmonary angiogenesis in mouse common bile duct ligation-induced liver fibrosis

Sarah RaevensLindsey DevisscherAnnelies ParidaensEliene BogaertsSander LefereYves-Paul VandewynckelCHRISTINE CASTELEYNKen BrackeTania MaesXavier VerhelstHans Van VlierbergheChristophe Van SteenkisteAnja GeertsIsabelle Colle

Laminin-332 sustains chemoresistance and quiescence as part of the human hepatic cancer stem cell niche

Olivier GovaereJasper WoutersMichaela PetzYves-Paul VandewynckelKathleen Van den EyndeAnke Van den broeckStefaan VerhulstLaurent DolléLies GremeauxAn CeulemansFrederik NevensLeo A van GrunsvenBaki TopalHugo VankelecomGianluigi GiannelliHans Van VlierbergheWolfgang MikulitsMina KomutaTania Roskams

A1 Journal Article in JOURNAL OF HEPATOLOGY

Next-generation proteasome inhibitor oprozomib synergizes with modulators of the unfolded protein response to suppress hepatocellular carcinoma

Yves-Paul VandewynckelCéline CouckeDebby LaukensLindsey DevisscherAnnelies ParidaensEliene BogaertsAstrid VandierendonckSarah RaevensXavier VerhelstChristophe Van SteenkisteLouis LibbrechtAnja GeertsHans Van Vlierberghe

Next-generation proteasome inhibitor oprozomib synergizes with modulators of the unfolded protein response to suppress hepatocellular carcinoma

Yves-Paul VandewynckelCéline CouckeDebby LaukensLindsey DevisscherAnnelies ParidaensEliene BogaertsAstrid VandierendonckSarah RaevensXavier VerhelstChristophe Van SteenkisteLouis LibbrechtAnja GeertsHans Van Vlierberghe

A1 Journal Article in ONCOTARGET

Placental growth factor inhibition modulates the interplay between hypoxia and unfolded protein response in hepatocellular carcinoma

Yves-Paul VandewynckelDebby LaukensLindsey DevisscherEliene BogaertsAnnelies ParidaensAnja Van den BusscheSarah RaevensXavier VerhelstChristophe Van SteenkisteBart JonckxLouis LibbrechtAnja GeertsPeter CarmelietHans Van Vlierberghe

A1 Journal Article in BMC CANCER

The bile acid tauroursodeoxycholic acid cooperates with N-acetylcysteine in the treatment of experimental acetaminophen-induced hepatotoxicity

Annelies ParidaensLindsey DevisscherSarah RaevensEliene BogaertsYves-Paul VandewynckelXavier VerhelstI MannaertsL Van GrunsvenHans Van VlierbergheIsabelle ColleAnja Geerts

The unfolded protein response underlies microenvironmental stress-induced phenotype switching leading to stemness and chemoresistance in human hepatocellular carcinoma

Yves-Paul VandewynckelO GovaereAstrid VandierendonckDebby LaukensLindsey DevisscherAnnelies ParidaensEliene BogaertsSarah RaevensXavier VerhelstChristophe Van SteenkisteLouis LibbrechtChristophe AmpeMarleen Van TroysAnja GeertsT RoskamsHans Van Vlierberghe

2015

Impact on angiogenesis and ER stress and its effect on chemoresistance through PlGF inhibition in a mouse model of hepatocellular carcinoma

Yves-Paul VandewynckelHans Van VlierbergheAnja Geerts

Modulation of the unfolded protein response impedes tumor cell adaptation to proteotoxic stress: a PERK for hepatocellular carcinoma therapy

Yves-Paul VandewynckelDebby LaukensEliene BogaertsAnnelies ParidaensAnja Van den BusscheXavier VerhelstChristophe Van SteenkisteBenedicte DescampsChristian VanhoveLouis LibbrechtRiet De RyckeBart LambrechtAnja GeertsSophie JanssensHans Van Vlierberghe

A1 Journal Article in HEPATOLOGY INTERNATIONAL

Phase I dose-escalation study evaluating the safety and pharmacokinetics of oral artesunate in patients with advanced hepatocullular carcinoma (DESPARTH trial)

Yves-Paul VandewynckelK RombautsXavier VerhelstLucas Van BortelBart De SpiegeleerAnja GeertsHans Van Vlierberghe

Placental growth factor inhibition modulates the interplay between hypoxia and the unfolded protein response in hepatocellular carcinoma

Yves-Paul VandewynckelDebby LaukensLindsey DevisscherAnnelies ParidaensEliene BogaertsXavier VerhelstAnja Van den BusscheSarah RaevensChristophe Van SteenkisteB JonckxLouis LibbrechtAnja GeertsP CarmelietHans Van Vlierberghe

Systematic review of guidelines for management of intermediate hepatocellular carcinoma using the Appraisal of Guidelines Research and Evaluation II instrument

Tom HolvoetSarah RaevensYves-Paul VandewynckelWim Van BiesenKaren GeboesHans Van Vlierberghe

A1 Journal Article in DIGESTIVE AND LIVER DISEASE

Tauroursodeoxycholic acid dampens oncogenic apoptosis induced by endoplasmic reticulum stress during hepatocarcinogen exposure

Yves-Paul VandewynckelDebby LaukensLindsey DevisscherAnnelies ParidaensEliene BogaertsXavier VerhelstAnja Van den BusscheSarah RaevensChristophe Van SteenkisteMarleen Van TroysChristophe AmpeBenedicte DescampsChristian VanhoveOlivier GovaereAnja GeertsHans Van Vlierberghe

A1 Journal Article in ONCOTARGET

Tauroursodeoxycholic acid dampens oncogenic apoptosis induced by endoplasmic reticulum stress during hepatocarcinogen exposure

Yves-Paul VandewynckelDebby LaukensLindsey DevisscherAnnelies ParidaensEliene BogaertsXavier VerhelstA Van den BusscheSarah RaevensChristophe Van SteenkisteMarleen Van TroysChristophe AmpeBenedicte DescampsChristian VanhoveO GovaereLouis LibbrechtAnja GeertsHans Van Vlierberghe

Time-dependent effect of hypoxia on tumor progression and liver progenitor cell markers in primary liver tumors

Eliene BogaertsFemke HeindryckxLindsey DevisscherAnnelies ParidaensYves-Paul VandewynckelAnja Van den BusscheXavier VerhelstLouis LibbrechtLeo A van GrunsvenAnja GeertsHans Van Vlierberghe

A1 Journal Article in PLOS ONE

2014

Endoplasmic reticulum stress and angiogenesis: is there an interaction between them?

Annelies ParidaensDebby LaukensYves-Paul VandewynckelStephanie CoulonHans Van VlierbergheAnja GeertsIsabelle Colle

A1 Journal Article in LIVER INTERNATIONAL

Intestinal metaplasia in an orthotopic mouse model for hepatocellular carcinoma

Yves-Paul VandewynckelRiet De RyckeEliene BogaertsHans Van Vlierberghe

Editorial material

Tauroursodeoxycholic acid inhibits experimental colitis by preventing early intestinal epithelial cell death

Debby LaukensLindsey DevisscherLien Van den BosschePieter HindryckxYves-Paul VandewynckelClaude CuvelierBrigitta BrinkmanClaude LibertPeter VandenabeeleMartine De Vos

A1 Journal Article in LABORATORY INVESTIGATION

Temporal dynamics and therapeutic potential of the unfolded protein espouse in hepatocellular carcinoma

Yves-Paul VandewynckelDebby LaukensAnja GeertsEliene BogaertsAnnelies ParidaensXavier VerhelstChristophe Van SteenkisteBenedicte DescampsChristian VanhoveLouis LibbrechtRiet De RyckeBart LambrechtSophie Janssens

Temporal dynamics and therapeutic potential of the unfolded protein response in hepatocellular carcinoma

Yves-Paul VandewynckelDebby LaukensAnja GeertsEliene BogaertsAnnelies ParidaensXavier VerhelstChristophe Van SteenkisteBenedicte DescampsChristian VanhoveLouis LibbrechtRiet De RyckeBart LambrechtS JanssensHans Van Vlierberghe

The roles of transforming growth factor-β, Wnt, Notch and hypoxia on liver progenitor cells in primary liver tumours

Eliene BogaertsFemke HeindryckxYves-Paul VandewynckelLeo A Van GrunsvenHans Van Vlierberghe

A1 Journal Article in INTERNATIONAL JOURNAL OF ONCOLOGY

Therapeutic effects of artesunate in hepatocellular carcinoma : repurposing an ancient antimalarial agent

Yves-Paul VandewynckelDebby LaukensAnja GeertsChristian VanhoveBenedicte DescampsLindsey DevisscherEliene BogaertsAnnelies ParidaensXavier VerhelstChristophe Van SteenkisteLouis LibbrechtBart LambrechtS JanssensHans Van Vlierberghe

Therapeutic effects of artesunate in hepatocellular carcinoma: repurposing an ancient antimalarial agent

Yves-Paul VandewynckelDebby LaukensAnja GeertsChristian VanhoveBenedicte DescampsIsabelle ColleLindsey DevisscherEliene BogaertsAnnelies ParidaensXavier VerhelstChristophe Van SteenkisteLouis LibbrechtBart LambrechtSophie JanssensHans Van Vlierberghe

A1 Journal Article in EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY

2013

Temporal dynamics of the unfolded protein response and chemoresistance in hepatocellular carcinoma

Yves-Paul VandewynckelIsabelle ColleDebby LaukensBart LambrechtBenedicte DescampsChristian VanhoveHans Van Vlierberghe

The paradox of the unfolded protein response in cancer

Yves-Paul VandewynckelDebby LaukensAnja GeertsEliene BogaertsAnnelies ParidaensXavier VerhelstSophie JanssensFemke HeindryckxHans Van Vlierberghe

A1 Journal Article in ANTICANCER RESEARCH

The therapeutic potential of artesunate in hepatocellular carcinoma

Yves-Paul VandewynckelDebby LaukensAnja GeertsIsabelle ColleLouis LibbrechtEliene BogaertsLindsey DevisscherAnnelies ParidaensXavier VerhelstChristian VanhoveBenedicte DescampsSophie JanssensBart LambrechtChristophe Van SteenkisteHans Van Vlierberghe