Research Explorer

Your browser does not support JavaScript or JavaScript is not enabled. Without JavaScript some functions of this webapplication may be disabled or cause error messages. To enable JavaScript, please consult the manual of your browser or contact your system administrator.

Researcher

Yves Dondelinger

Awards & Distinctions

26 Results

2023

NINJ1 is activated by cell swelling to regulate plasma membrane permeabilization during regulated necrosis

Yves DondelingerDario PriemJon HuygheTom DelanghePeter VandenabeeleMathieu Bertrand

A1 Journal Article in CELL DEATH & DISEASE

RIPK1 kinase-dependent inflammation and cell death contribute to the pathogenesis of COPD

Hannelore Van EeckhoutteChantal DonovanRichard Y. KimThomas M. ConlonMeshal AnsariHaroon KhanRanjith JayaramanNicole G. HansbroYves DondelingerTom Delanghe et al.

A1 Journal Article in EUROPEAN RESPIRATORY JOURNAL

2022

Phosphorylation of RIPK1 serine 25 mediates IKK dependent control of extrinsic cell death in T cells

Sam BlanchettYves DondelingerAlessandro BarbaruloMathieu BertrandBenedict Seddon

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Rothia mucilaginosa is an anti-inflammatory bacterium in the respiratory tract of patients with chronic lung disease

Charlotte RigautsJuliana AizawaSteven TaylorGeraint B. RogersMatthias GovaertsPaul CosLisa OstynSarah SimsEva VandeplasscheMozes Sze et al.

A1 Journal Article in EUROPEAN RESPIRATORY JOURNAL

The Impact of RIPK1 Kinase Inhibition on Atherogenesis: A Genetic and a Pharmacological Approach

Pauline PuylaertIsabelle CoornaertCedric H. G. NeutelYves DondelingerTom DelangheMathieu BertrandPieter-Jan GunsGuido R. Y. De MeyerWim Martinet

A1 Journal Article in BIOMEDICINES

2021

Antioxidant and food additive BHA prevents TNF cytotoxicity by acting as a direct RIPK1 inhibitor

Tom DelangheJon HuygheSeungheon LeeDario PriemSamya Van CoillieBarbara GilbertSze Men ChoiPeter VandenabeeleAlexei DegterevGregory D. Cuny et al.

A1 Journal Article in CELL DEATH & DISEASE

Unraveling the role of RIPK1 phosphorylation in TNF-mediated cell death and inflammation

Tom DelangheMathieu BertrandYves Dondelinger

2020

RIPK1 kinase-dependent death : a symphony of phosphorylation events

Tom DelangheYves DondelingerMathieu Bertrand

A1 Journal Article in TRENDS IN CELL BIOLOGY

Respiratory Syncytial Virus infection promotes necroptosis and HMGB1 release by airway epithelial cells

Jennifer SimpsonZhixuan LohMd Ashik UllahJason P LynchRhiannon B. WerderNatasha CollinsonVivian ZhangYves DondelingerMathieu BertrandMark L. Everard et al.

A1 Journal Article in AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

2019

Serine 25 phosphorylation inhibits RIPK1 kinase-dependent cell death in models of infection and inflammation

Yves DondelingerTom DelangheDario PriemMeghan A Wynosky-DolfiDaniel SorobeteaDiego Rojas RiveraPiero GiansantiRia RoelandtJulia GropengiesserKlaus Ruckdeschel et al.

A1 Journal Article in NATURE COMMUNICATIONS

2018

MK2 puts an additional brake on RIPK1 cytotoxic potential

Yves DondelingerTom DelangheMathieu Bertrand

Editorial material

Monitoring RIPK1 phosphorylation in the TNFR1 signaling complex

Dario PriemYves DondelingerMathieu Bertrand

Bookchapter in Programmed necrosis : methods and protocols

N-glycosylation of mouse TRAIL-R restrains TRAIL-induced apoptosis

Yann EstornesYves DondelingerKathrin WeberInge BruggemanAdam PeallMarion MacFarlaneSerge LebecquePeter VandenabeeleMathieu Bertrand

A1 Journal Article in CELL DEATH & DISEASE

2017

MK2 phosphorylation of RIPK1 regulates TNF-mediated cell death

Yves DondelingerTom DelangheDiego Rojas RiveraDario PriemTinneke DelvaeyeInge BruggemanFranky Van HerreweghePeter VandenabeeleMathieu Bertrand

A1 Journal Article in NATURE CELL BIOLOGY

2016

A real-time fluorometric method for the simultaneous detection of cell death type and rate

Sasker GrootjansBehrouz HassanniaIris DelrueVera GoossensBartosz WiernickiYves DondelingerMathieu BertrandDmitri KryskoMarnik VuylstekePeter Vandenabeele et al.

A1 Journal Article in NATURE PROTOCOLS

An evolutionary perspective on the necroptotic pathway

Yves DondelingerPaco HulpiauYvan SaeysMathieu BertrandPeter Vandenabeele

A1 Journal Article in TRENDS IN CELL BIOLOGY

CHIP controls necroptosis through ubiquitylation- and lysosome-dependent degradation of RIPK3

Jinho SeoEun-Woo LeeHyerim SungDaehyeon SeongYves DondelingerJihye ShinManhyung JeongHae-Kyung LeeJung-Hoon KimSu Yeon Han et al.

A1 Journal Article in NATURE CELL BIOLOGY

Poly-ubiquitination in TNFR1-mediated necroptosis

Yves DondelingerMaurice DardingMathieu BertrandHenning Walczak

A1 Journal Article in CELLULAR AND MOLECULAR LIFE SCIENCES

Regulation of RIPK1's cell death function by phosphorylation

Yves DondelingerPeter VandenabeeleMathieu Bertrand

Editorial material

2015

NF-κB-independent role of IKKα/IKKβ in preventing RIPK1 kinase-dependent apoptotic and necroptotic cell death during TNF signaling

Yves DondelingerSandrine JouanTatyana DivertEmilie TheatreJohn BertinPeter J GoughPiero GiansantiAlbert JR HeckEmmanuel DejardinPeter Vandenabeele et al.

A1 Journal Article in MOLECULAR CELL

Unraveling the molecular mechanisms of RIPK1-mediated cell death

Yves DondelingerPeter VandenabeeleMathieu Bertrand

2014

Depletion of RIPK3 or MLKL blocks TNF-driven necroptosis and switches towards a delayed RIPK1 kinase-dependent apoptosis

Quinten RemijsenVera GoossensSasker GrootjansC Van den HauteNele VanlangenakkerYves DondelingerRia RoelandtInge BruggemanAmanda GonçalvesMathieu Bertrand et al.

A1 Journal Article in CELL DEATH & DISEASE

MLKL compromises plasma membrane integrity by binding to phosphatidylinositol phosphates

Yves DondelingerWim DeclercqSylvie MontessuitRia RoelandtAmanda GonçalvesInge BruggemanPaco HulpiauKathrin WeberClark A SehonRobert W Marquis et al.

A1 Journal Article in CELL REPORTS

2013

Determination of apoptotic and necrotic cell death in vitro and in vivo

Tom Vanden BergheSasker GrootjansVera GoossensYves DondelingerDmitri KryskoNozomi TakahashiPeter Vandenabeele

A1 Journal Article in METHODS

RIPK3 contributes to TNFR1-mediated RIPK1 kinase-dependent apoptosis in conditions of cIAP1/2 depletion or TAK1 kinase inhibition

Yves DondelingerMiguel AguiletaVera GoossensChristel DubuissonSasker GrootjansE DejardinPeter VandenabeeleMathieu Bertrand

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

2012

Intermediate domain of receptor-interacting protein kinase 1 (RIPK1) determines switch between necroptosis and RIPK1 kinase-dependent apoptosis

Linde DuprezMathieu BertrandTom Vanden BergheYves DondelingerNele FestjensPeter Vandenabeele

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY