Research Explorer

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Researcher

Yong Chen

Publications & Research Data

Awards & Distinctions

19 Results

2025

A fentanyl hapten-displaying lipid nanoparticle vaccine that non-covalently encapsulates a TLR7/8 agonist and T-helper epitope induces protective anti-fentanyl immunity

Zifu ZhongMarie DeventerYong ChenStijn VanheeInés LammensKim DeswarteYi HuangTingting YeHaixiu WangLutz Nuhn et al.

A1 Journal Article in ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Admixing of mRNA with pre‐formed lipid nanoparticles containing a slightly‐cationic ionizable lipid allows for efficient mRNA transfection in vitro and in vivo

Haixiu WangHeleen LauwersMark GontsarikYong ChenNiek SandersMiffy Hok Yan ChengBruno De GeestZifu Zhong

A1 Journal Article in ADVANCED HEALTHCARE MATERIALS

Thioamides adjacent to the ionizable amine headgroup in ionizable lipids reduce the pKa of lipid nanoparticles and enhance mRNA transfection efficiency in vitro and in vivo

Yong ChenEmily De LombaerdeAimee-Rose Bugler-LambZifu ZhongMartijn SchuijsClaudia Mariela Brenis GómezJamie De BaereMark GontsarikHeleen LauwersKim Deswarte et al.

A1 Journal Article in ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

2024

Amplification of protein expression by self-amplifying mRNA delivered in lipid nanoparticles containing a β-aminoester ionizable lipid correlates with reduced innate immune activation

Emily De LombaerdeXiaole CuiYong ChenZifu ZhongJulie DeckersGiulia MencarelliLisa OpsomerHaixiu WangJamie De BaereStefan Lienenklaus et al.

A1 Journal Article in ACS NANO

CO-DELIVERY of glutamic acid-extended peptide antigen and imidazoquinoline TLR7/8 agonist via ionizable lipid nanoparticles induces protective anti-tumor immunity

Tingting YeZifu ZhongFederica CappellessoKim DeswarteYong ChenHeleen LauwersEmily De LombaerdeMark GontsarikStefan LienenklausDorien Van Lysebetten et al.

A1 Journal Article in BIOMATERIALS

Combinatorial screening of biscarbamate ionizable lipids identifies a low reactogenicity lipid for lipid nanoparticle mRNA delivery

Emily De LombaerdeYong ChenTingting YeJulie DeckersGiulia MencarelliKim DeswarteHeleen LauwersRuben De CoenSabah KasmiSanne Bevers et al.

A1 Journal Article in ADVANCED FUNCTIONAL MATERIALS

Dual-ligand PROTACS mediate superior target protein degradation in vitro and therapeutic efficacy in vivo

Yong ChenZihan XiaUjjwal SuwalPekka RappuJyrki HeinoOlivier De WeverBruno De Geest

A1 Journal Article in CHEMICAL SCIENCE

Galloyl dialkyl lipids drive encapsulation of peptides into lipid nanoparticles by hydrogen bonding

Tingting YeYong ChenZifu ZhongYi HuangJamie De BaereMark GontsarikKim DeswarteBianka GolbaMartijn RisseeuwSerge Van Calenbergh et al.

A1 Journal Article in JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

HER2 nanobody-poly(rhamnose) conjugates efficiently recruit anti-rhamnose antibodies from serum to the surface of HER2-expressing cells

Weiwei MuYong ChenZifu ZhongBenoit LouageHeleen LauwersNick DevoogdtJurgen HaustraeteBruno De Geest

A1 Journal Article in CHEMISTRY OF MATERIALS

Lipid nanoparticle composition for adjuvant formulation modulates disease after influenza virus infection in quadrivalent influenza vaccine vaccinated mice

Sonia JangraAlexander LamootGagandeep SinghGabriel LaghlaliYong ChenTingting YeAdolfo García-SastreBruno De GeestMichael Schotsaert

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Lipid nanoparticle encapsulation empowers poly(I:C) to activate cytoplasmic RLRs and thereby increases its adjuvanticity

Alexander LamootSonia JangraGabriel LaghlaliPrajakta WarangLauren A. ChangSeok‐Chan ParkGagandeep SinghKim DeswarteZifu ZhongBenoit Louage et al.

A1 Journal Article in SMALL

Lysosomal trafficking and degradation of extracellular proteins via multivalent small molecule ligand display on dextran scaffolds

Benoit LouageDemi DefreyneHeleen LauwersJamie De BaereAnnemiek UvynHaixia PengYong ChenBruno De Geest

A1 Journal Article in BIOMACROMOLECULES

2023

Influenza breakthrough infection in vaccinated mice is characterized by non-pathological lung eosinophilia

Lauren A. ChangAngela ChoiRaveen RathnasinghePrajakta WarangMoataz NoureddineSonia JangraYong ChenBruno De GeestMichael Schotsaert

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Lipid nanoparticle delivery alters the adjuvanticity of the TLR9 agonist CpG by innate immune activation in lymphoid tissue

Zifu ZhongYong ChenKim DeswarteHeleen LauwersEmily De LombaerdeXiaole CuiSimon Van HerckTingting YeMark GontsarikStefan Lienenklaus et al.

A1 Journal Article in ADVANCED HEALTHCARE MATERIALS

Smart hydrogels delivered by high pressure aerosolization can prevent peritoneal adhesions

Helena BraetPeter-Paul FransenYong ChenSimon Van HerckRemco MariënValérie VanhoorneWim CeelenAnnemieke MadderSteven BalletRichard Hoogenboom et al.

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

Successful batch and continuous lyophilization of mRNA LNP formulations depend on cryoprotectants and ionizable lipids

Alexander LamootJoris LammensEmily De LombaerdeZifu ZhongMark GontsarikYong ChenThomas De BeerBruno De Geest

A1 Journal Article in BIOMATERIALS SCIENCE

2022

RIG-I and TLR-7/8 agonists as combination adjuvant shapes unique antibody and cellular vaccine responses to seasonal influenza vaccine

Sonia JangraGabriel LaghlaliAngela ChoiRaveen RathnasingheYong ChenSoner YildizLynda CoughlanAdolfo García-SastreBruno De GeestMichael Schotsaert

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

2021

Lipid-polyglutamate nanoparticle vaccine platform

Dorien Van LysebettenAlessio MalfantiKim DeswarteKaloian KoynovBianka GolbaTingting YeZifu ZhongSabah KasmiAlexander LamootYong Chen et al.

A1 Journal Article in ACS APPLIED MATERIALS & INTERFACES

2020

Potent and prolonged innate immune activation by enzyme-responsive imidazoquinoline TLR7/8 agonist prodrug vesicles

Bi WangSimon Van HerckYong ChenXiangyang BaiZifu ZhongKim DeswarteBart LambrechtNiek SandersStefan LienenklausHans W. Scheeren et al.

A1 Journal Article in JOURNAL OF THE AMERICAN CHEMICAL SOCIETY