Research Explorer

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Researcher

Yehudi Bloch

Awards & Distinctions

18 Results

2024

Structures of complete extracellular receptor assemblies mediated by IL-12 and IL-23

Yehudi BlochJan FélixRomain MerceronMathias ProvostRoyan Alipour SymakaniRobin De BackerElisabeth LambertAhmadreza MehdipourSavvas Savvides

A1 Journal Article in NATURE STRUCTURAL & MOLECULAR BIOLOGY

2022

Point mutation I634A in the glucocorticoid receptor causes embryonic lethality by reduced ligand binding

Steven TimmermansNicolette J.D. VerhoogKelly Van LooverenSylviane DewaeleTino HochepiedMelanie EggermontBarbara GilbertAnne Boerema-de MunckTineke VanderhaeghenJoke Vanden Berghe et al.

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Structural basis of activation and antagonism of receptor signaling mediated by interleukin-27

Katarzyna SkladanowskaYehudi BlochJamie StrandKerry F. WhiteJing HuaDaniel AldridgeMartin WelinDerek T. LoganArne SoeteRomain Merceron et al.

A1 Journal Article in CELL REPORTS

Structural basis of human IL-18 sequestration by the decoy receptor IL-18 binding protein in inflammation and tumor immunity

Sammy DetryJulie AndriesYehudi BlochCem GabayDanielle ClancySavvas Savvides

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

2021

Distinct EH domains of the endocytic TPLATE complex confer lipid and protein binding

Klaas YpermanAnna PapageorgiouRomain MerceronSteven De MunckYehudi BlochDominique EeckhoutQihang JiangPieter TackRosa GrigoryanThomas Evangelidis et al.

A1 Journal Article in NATURE COMMUNICATIONS

Structural basis of cytokine-mediated activation of ALK family receptors

Steven De MunckMathias ProvostMichiko KurikawaIkuko OmoriJunko MukohyamaJan FélixYehudi BlochOmar Abdel-WahabJ. Fernando BazanAkihide Yoshimi et al.

A1 Journal Article in NATURE

2020

Homogeneously N-glycosylated proteins derived from the GlycoDelete HEK293 cell line enable diffraction-quality crystallogenesis

Sandra KozakYehudi BlochSteven De MunckAleksandra MikulaIsabel BentoSavvas SavvidesRob Meijers

A1 Journal Article in ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY

2019

Pathophysiology and inhibition of IL-23 signaling in psoriatic arthritis : a molecular insight

Cuong Thach NguyenYehudi BlochKatarzyna SkladanowskaSavvas SavvidesIannis E Adamopoulos

A1 Journal Article in CLINICAL IMMUNOLOGY

Revisiting the combinatorial potential of cytokine subunits in the IL-12 family

Sammy DetryKatarzyna SkladanowskaMarnik VuylstekeSavvas SavvidesYehudi Bloch

A1 Journal Article in BIOCHEMICAL PHARMACOLOGY

Structure of ATP citrate lyase and the origin of citrate synthase in the Krebs cycle

Koen VerschuerenClement BlanchetJan FelixAnn DansercoerDirk De VosYehudi BlochJozef Van BeeumenDmitri SvergunIrina GutscheSavvas Savvides et al.

A1 Journal Article in NATURE

Unraveling and targeting of molecular signaling mechanisms of IL-12 family, IL-18 and IL-33 cytokines using integrative structural biology

Sammy DetrySavvas SavvidesYehudi Bloch

2018

Stabilization of cytokine mRNAs in iNKT cells requires the serine-threonine kinase IRE1alpha

Srinath GovindarajanDjoere GaublommeRenée Van der CruyssenEveline VerheugenSofie Van GassenYvan SaeysSimon TavernierTakao IwawakiYehudi BlochSavvas Savvides et al.

A1 Journal Article in NATURE COMMUNICATIONS

Structural activation of pro-inflammatory human cytokine IL-23 by cognate IL-23 receptor enables recruitment of the shared receptor IL-12Rβ1

Yehudi BlochLaura BouchareychasRomain MerceronKatarzyna SkladanowskaLien Van den BosscheSammy DetrySrinath GovindarajanDirk ElewautFilomeen HaerynckMelissa Dullaers et al.

A1 Journal Article in IMMUNITY

Structure, mechanism and antagonism of the pro-inflammatory receptor complex mediated by interleukin-23

Yehudi BlochSavvas SavvidesKenneth Verstraete

2016

Structural basis of GM-CSF and IL-2 sequestration by the viral decoy receptor GIF

Jan FélixEaazhisai KandiahSteven De MunckYehudi BlochGydo CP van ZundertKris PauwelsAnn DansercoerKatka NovanskaRandy J ReadAlexandre MJJ Bonvin et al.

A1 Journal Article in NATURE COMMUNICATIONS

2014

Characterization of a type D1A EUL-related lectin from rice expressed in Pichia pastoris

Bassam Al AtalahDieter VanderschaegheYehudi BlochPaul ProostKirsten PlasNico CallewaertSavvas SavvidesEls Van Damme

A1 Journal Article in BIOLOGICAL CHEMISTRY

Structural basis of IL-23 antagonism by an Alphabody protein scaffold

Johan DesmetKenneth VerstraeteYehudi BlochEric LorentYurong WenBart DevreeseKaren VandenbrouckeStefan LoverixThore HettmannSabrina Deroo et al.

A1 Journal Article in NATURE COMMUNICATIONS

Structural basis of the proinflammatory signaling complex mediated by TSLP

Kenneth VerstraeteLoes van SchieLaurens VynckeYehudi BlochJan TavernierEwald PauwelsFrank PeelmanSavvas Savvides

A1 Journal Article in NATURE STRUCTURAL & MOLECULAR BIOLOGY