Research Explorer

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Researcher

Xavier Saelens

Publications & Research Data

Awards & Distinctions

251 Results

2025

Europe needs a sustainably funded influenza research and response network

Florian KrammerWendy S BarclayMartin BeerIan H BrownRebecca Jane CoxMenno D de JongErvin FodorRon A M FouchierGülsah GabrielAdolfo García-Sastre et al.

Editorial material

Identification and characterization of heptad repeat 2 as a target for neutralizing antibodies on the SARS coronavirus spike

Sieglinde De CaeXavier SaelensBert Schepens

Identification of DksA as a novel pro-inflammatory mediator of <i>Pseudomonas aeruginosa</i> under conditions mimicking chronic cystic fibrosis lung infection

Merel WautersLaura BolléSara Van den BosscheLucia GrassiDelphi Van HaverSara DufourSimon DevosFrancis ImpensEva Van BraeckelAnna K.H. Hirsch et al.

Impact of pre-existing anti-replicase immunity on the efficacy of self-amplifying mRNA vaccines

Xiaole CuiLaura AmelinckOriane GillonJoão Paulo Portela CataniYa GaoQing SunElisabeth De SutterPieter VervaekeJanne SnoeckStefan Lienenklaus et al.

A1 Journal Article in NATURE COMMUNICATIONS

Myxovirus resistance (Mx) interacting proteins

Georgios MoschonasXavier SaelensSven Eyckerman

Pan-influenza B control with single-domain antibodies directed against hemagglutinin and neuraminidase

Arne MatthysXavier SaelensJoão Portela Catani

Single-domain antibodies directed against hemagglutinin and neuraminidase protect against influenza B viruses

Arne MatthysJan FélixJoão Portela CataniKenny RooseWim NerinckxBenthe Van BuytenDaria FijalkowskaNico CallewaertSavvas SavvidesXavier Saelens

A1 Journal Article in NATURE COMMUNICATIONS

Ultrapotent SARS coronavirus-neutralizing single-domain antibodies that clamp the spike at its base

Sieglinde De CaeInge Van MolleLoes van SchieSophie R. ShoemakerJulie DeckersNincy DebeufSahine LameireWim NerinckxKenny RooseDaria Fijalkowska et al.

A1 Journal Article in NATURE COMMUNICATIONS

Unraveling the immunosuppressive role of Elastase B produced by cystic fibrosis isolates of Pseudomonas aeruginosa in an organotypic 3-D lung epithelial cell model

Merel WautersLeander MeurisAurélie CrabbéXavier Saelens

Unraveling the immunosuppressive role of Elastase B produced by cystic fibrosis isolates of Pseudomonas aeruginosa in an organotypic 3D lung epithelial cell model

Merel WautersSara Van den BosscheLucia GrassiMariana Fernandes GonçalvesDelphi Van HaverSara DufourSimon DevosLeander MeurisFrancis ImpensXavier Saelens et al.

A1 Journal Article in VIRULENCE

2024

A neutralizing single-domain antibody that targets the trimer interface of the human metapneumovirus fusion protein

Marlies BallegeerRevina C. van ScherpenzeelTeresa DelgadoMaria Iglesias-CaballeroBlanca García BarrenoShubham PandeyScott A. RushJoost A. KolkmanVicente MasJason S. McLellan et al.

A1 Journal Article in MBIO

A new MVA ancestor-derived oncolytic vaccinia virus induces immunogenic tumor cell death and robust antitumor immune responses

Juan J. RojasLien Van HoeckeMiquel ConesaCarmen Bueno-MerinoAna del CanizoStephanie RiedererMaria BarciaKatrin BrosinskiMichael H. LehmannAsisa Volz et al.

A1 Journal Article in MOLECULAR THERAPY

Direct and ultrasensitive bioluminescent detection of intact respiratory viruses

Alexander GräweHarm van der VeerSeino A. K. JongkeesJacky FlipseIebe RosseyRobert P. de VriesXavier SaelensMaarten Merkx

A1 Journal Article in ACS SENSORS

Host dependency factors of the influenza virus : a dual-omics approach

Annabel MaesXavier SaelensFrancis Impens

Integrating artificial intelligence-based epitope prediction in a SARS-CoV-2 antibody discovery pipeline : caution is warranted

Delphine Diana AcarWojciech WitkowskiMagdalena WejdaRuifang WeiTim DesmetBert SchepensSieglinde De CaeKoen SedeynHannah EeckhautDaria Fijalkowska et al.

A1 Journal Article in EBIOMEDICINE

MX2 forms nucleoporin-comprising cytoplasmic biomolecular condensates that lure viral capsids

Georgios MoschonasLouis DelhayeRobin CooremanFranziska HuesersAnayat BhatZoi StylianidouElien De BousserLaure De PryckHanna GrzesikDelphine De Sutter et al.

A1 Journal Article in CELL HOST & MICROBE

Nanoparticle display of neuraminidase elicits enhanced antibody responses and protection against influenza A virus challenge

M. N. PaschaMarlies BallegeerM. C. RoelofsLeander MeurisI. C. AlbulescuF. J. M. van KuppeveldD. L. HurdissB. J. BoschT. Zeev-Ben-MordehaiXavier Saelens et al.

A1 Journal Article in NPJ VACCINES

Need for standardization of Influenza A virus-induced cell death in vivo to improve consistency of inter-laboratory research findings

Teodora-Eugenia OlteanJonathan MaelfaitXavier SaelensPeter Vandenabeele

A1 Journal Article in CELL DEATH DISCOVERY

Promises and challenges of single-domain antibodies to control influenza

Arne MatthysXavier Saelens

A1 Journal Article in ANTIVIRAL RESEARCH

Repeated COVID-19 mRNA-based vaccination contributes to SARS-CoV-2 neutralizing antibody responses in the mucosa

Jozefien DeclercqSarah GerloSharon Van NevelNatalie De RuyckGabriële HoltappelsLiesbeth DelesieEls TobbackInés LammensNikita GerebtsovKoen Sedeyn et al.

A1 Journal Article in SCIENCE TRANSLATIONAL MEDICINE

Systematic review and meta-analysis of genome-wide pooled CRISPR screens to identify host factors involved in influenza A virus infection

Annabel MaesAlexander BotzkiJanick MathysFrancis ImpensXavier Saelens

A1 Journal Article in JOURNAL OF VIROLOGY

The antigenic landscape of human influenza N2 neuraminidases from 2009 until 2017

João Portela CataniAnouk SmetTine YsenbaertMarnik VuylstekeGuy BottuJanick MathysAlexander BotzkiGuadalupe Cortes-GarciaTod StrugnellRaul Gomila et al.

A1 Journal Article in eLife

2023

Anti-neuraminidase and anti-hemagglutinin immune serum can confer inter-lineage cross protection against recent influenza B

João Portela CataniTine YsenbaertAnouk SmetMarnik VuylstekeThorsten U. VogelXavier Saelens

A1 Journal Article in PLOS ONE

Cleavage of cFLIP restrains cell death during viral infection and tissue injury and favors tissue repair

Kristel Martinez LagunasDeniz Pinar SavcigilMatea ZrilicCarlos Carvajal FraileAndrew CraxtonEmily SelfIratxe Uranga-MurilloDiego de MiguelMaykel AriasSebastian Willenborg et al.

A1 Journal Article in SCIENCE ADVANCES

Development of digital droplet PCR targeting the influenza H3N2 sseltamivir-resistant E119V mutation and its performance through the use of reverse genetics mutants

Laura Van PoelvoordeFrançois E. DufrasneSteven Van GuchtXavier SaelensNancy H. C. Roosens

A1 Journal Article in CURRENT ISSUES IN MOLECULAR BIOLOGY

Epidemiology of influenza over a ten-year period in Belgium : overview of the historical and current evidence

Andrea PrezziXavier SaelensDominique Vandijck

A1 Journal Article in VIROLOGY JOURNAL

Exploring the added value of Whole Genome Sequencing in routine and pandemic viral surveillance

Laura Van PoelvoordeXavier SaelensNancy Roosens

GlycoVHH : optimal sites for introducing N-glycans on the camelid VHH antibody scaffold and use for macrophage delivery

Loes van SchieWander Van BreedamCharlotte RoelsBert SchepensMartin FrankAhmadreza MehdipourBram LaukensWim NerinckxFrancis SantensSimon Devos et al.

A1 Journal Article in MABS

Proteomic data and structure analysis combined reveal interplay of structural rigidity and flexibility on selectivity of cysteine cathepsins

Livija TušarJure LobodaFrancis ImpensPiotr SosnowskiEmmy Van QuickelbergheRobert VidmarHans DemolKoen SedeynXavier SaelensMatej Vizovišek et al.

A1 Journal Article in COMMUNICATIONS BIOLOGY

Rethinking IL-1 antagonism in respiratory viral infections : a role for IL-1 signaling in the development of antiviral T cell immunity

Bram Van Den EeckhoutMarlies BallegeerJozefien De ClercqElianne BurgXavier SaelensLinos VandekerckhoveSarah Gerlo

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Unraveling the host-RSV interplay by proteomic approaches

Tessa Van RoyenXavier SaelensKoen Sedeyn

2022

A general approach to identify low-frequency variants within influenza samples collected during routine surveillance

Laura Van PoelvoordeThomas DelcourtMarnik VuylstekeSigrid C. J. De KeersmaeckerIsabelle ThomasSteven Van GuchtXavier SaelensNancy RoosensKevin Vanneste

A1 Journal Article in MICROBIAL GENOMICS

ADP-ribosylating adjuvant reveals plasticity in cDC1 cells that drive mucosal Th17 cell development and protection against influenza virus infection

Mohammad ArabpourCristina Lebrero-FernandezKarin SchönAnneli StrömbergVanja BörjessonKatharina LahlMarlies BallegeerXavier SaelensDavide AngelettiWilliam Agace et al.

A1 Journal Article in MUCOSAL IMMUNOLOGY

An unexpected encounter : respiratory syncytial virus nonstructural protein 1 interacts with mediator subunit MED25

Tessa Van RoyenKoen SedeynGeorgios MoschonasWendy ToussaintM VuylstekeDelphi Van HaverFrancis ImpensSven EyckermanIrma LemmensJan Tavernier et al.

A1 Journal Article in JOURNAL OF VIROLOGY

Antibodies directed towards neuraminidase restrict influenza virus replication in primary human bronchial epithelial cells

Anouk SmetJoão Portela CataniTine YsenbaertAmanda GonçalvesHarry KleanthousThorsten U. VogelXavier SaelensEmma Job

A1 Journal Article in PLOS ONE

Clonotypic analysis of protective influenza M2e-specific lung resident Th17 memory cells reveals extensive functional diversity

Ajibola OmokanyeLi Ching OngCristina Lebrero-FernandezValentina BernasconiKarin SchönAnneli StrömbergMats BemarkXavier SaelensPaulo CzarnewskiNils Lycke

A1 Journal Article in MUCOSAL IMMUNOLOGY

Controlling swine influenza viruses through assessments of a live attenuated vaccine strain and their relative zoonotic risk

Elien VandoornKristien Van ReethXavier Saelens

Cov²MS : an automated and quantitative matrix-independent assay for mass spectrometric measurement of SARS-CoV-2 nucleocapsid protein

Bart Van PuyveldeKatleen Van UytfangheLaurence Van OudenhoveRalf GabrielsTessa Van RoyenArne MatthysMorteza RazaviRichard YipTerry PearsonNicolas Drouin et al.

A1 Journal Article in ANALYTICAL CHEMISTRY

Developing methods for the production of antiviral VHH-Fc antibodies in Pichia pastoris for fast pandemic response

Chiara LonigroNico CallewaertXavier Saelens

How RSV proteins join forces to overcome the host innate immune response

Tessa Van RoyenIebe RosseyKoen SedeynBert SchepensXavier Saelens

A1 Journal Article in VIRUSES

Pre-existing antibodies directed against a tetramerizing domain enhance the immune response against artificially stabilized soluble tetrameric influenza neuraminidase

João Paulo Portela CataniEmma JobTine YsenbaertAnouk SmetSatyajit RayLauren LaRueSvetlana StegalkinaMario BarroThorsten U. VogelXavier Saelens

A1 Journal Article in NPJ VACCINES

Reduced protection of RIPK3-deficient mice against influenza by matrix protein 2 ectodomain targeted active and passive vaccination strategies

Teodora-Eugenia OlteanLorena IbanezTatyana DivertTine YsenbaertHannelore Van EeckhoutteVera GoossensMichael SchotsaertKen BrackeBert SchepensJonathan Maelfait et al.

A1 Journal Article in CELL DEATH & DISEASE

Single domain antibodies to probe the antiviral function of human MxA

Eline SoetensXavier SaelensMarlies Ballegeer

Studies on the diversity of swine influenza viruses and how to exploit it for vaccination

Anna ParysKristien Van ReethXavier Saelens

Whole-genome sequence approach and phylogenomic stratification improve the association analysis of mutations with patient data in influenza surveillance

Laura Van PoelvoordeKevin VannesteSigrid C. J. De KeersmaeckerIsabelle ThomasNina Van GoethemSteven Van GuchtXavier SaelensNancy H. C. Roosens

A1 Journal Article in FRONTIERS IN MICROBIOLOGY

2021

A vulnerable, membrane-proximal site in human respiratory syncytial virus F revealed by a prefusion-specific single-domain antibody

Iebe RosseyChing-Lin HsiehKoen SedeynMarlies BallegeerBert SchepensJason S. McLellanXavier Saelens

A1 Journal Article in JOURNAL OF VIROLOGY

An affinity-enhanced, broadly neutralizing heavy chain-only antibody protects against SARS-CoV-2 infection in animal models

Bert SchepensLoes van SchieWim NerinckxKenny RooseWander Van BreedamDaria FijalkowskaSimon DevosWannes WeytsSieglinde De CaeSandrine Vanmarcke et al.

A1 Journal Article in SCIENCE TRANSLATIONAL MEDICINE

In vivo therapy with M2e-specific IgG selects for an influenza A virus mutant with delayed matrix protein 2 expression

Silvie Van den HoeckeMarlies BallegeerBram VranckenLei DengEmma JobKenny RooseBert SchepensLien Van HoeckePhilippe LemeyXavier Saelens

A1 Journal Article in MBIO

Influenza neuraminidase characteristics and potential as a vaccine target

Sarah CreytensMirte N. PaschaMarlies BallegeerXavier SaelensCornelis A. M. de Haan

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Protective efficacy of recombinant influenza hemagglutinin ectodomain fusions

Nidhi MittalNayanika SenguptaSameer Kumar MalladiPoorvi ReddyMadhuraj BhatRaju S. RajmaniKoen SedeynXavier SaelensSomnath DuttaRaghavan Varadarajan

A1 Journal Article in VIRUSES-BASEL

Ring finger protein 213 assembles into a sensor for ISGylated proteins with antimicrobial activity

Fabien Henri TheryLia MartinaCaroline AsselmanHeidi RepoY ZhangKoen SedeynGeorgios MoschonasC BredowQW TeoJ Zhang et al.

A1 Journal Article in NATURE COMMUNICATIONS

Single-domain antibodies make a difference

Xavier SaelensBert Schepens

Editorial material

Strategy and performance evaluation of low-frequency variant calling for SARS-CoV-2 using targeted deep Illumina sequencing

Laura Van PoelvoordeThomas DelcourtWim CouckePhilippe HermanSigrid C. J. De KeersmaeckerXavier SaelensNancy H. C. RoosensKevin Vanneste

A1 Journal Article in FRONTIERS IN MICROBIOLOGY

Viral dosing of influenza A infection reveals involvement of RIPK3 and FADD, but not MLKL

Teodora-Eugenia OlteanEmily Van SanTatyana DivertTom Vanden BergheXavier SaelensJonathan MaelfaitNozomi TakahashiPeter Vandenabeele

A1 Journal Article in CELL DEATH & DISEASE

Whole-genome-based phylogenomic analysis of the Belgian 2016–2017 influenza A(H3N2) outbreak season allows improved surveillance

Laura Van PoelvoordeBert BogaertsQiang FuSigrid C. J. De KeersmaeckerIsabelle ThomasNina Van GoethemSteven Van GuchtRaf WinandXavier SaelensNancy Roosens et al.

A1 Journal Article in MICROBIAL GENOMICS

2020

An inside job : applications of intracellular single domain antibodies

Eline SoetensMarlies BallegeerXavier Saelens

A1 Journal Article in BIOMOLECULES

Cell-mediated responses to human metapneumovirus infection

Marlies BallegeerXavier Saelens

A1 Journal Article in VIRUSES-BASEL

Evaluation of the protective potential of antibody and T cell responses elicited by a novel preventative vaccine towards respiratory syncytial virus small hydrophobic protein

Heather L. TorreyValarmathy KaliaperumalYogesh BramhechaGenevieve M. WeirAnn R. FalseyEdward E. WalshJoanne M. LangleyBert SchepensXavier SaelensMarianne M. Stanford

A1 Journal Article in HUMAN VACCINES & IMMUNOTHERAPEUTICS

Intracellular delivery of mRNA in adherent and suspension cells by vapor nanobubble photoporation

Laurens RaesStephan StremerschJuan FraireToon BransGlenn GoetgelukStijn De MunterLien Van HoeckeRein VerbekeJelter Van HoeckRanhua Xiong et al.

A1 Journal Article in NANO-MICRO LETTERS

mRNA encoding a bispecific single domain antibody construct protects against influenza A virus infection in mice

Lien Van HoeckeRein VerbekeDorien De VliegerHeleen DewitteKenny RooseSharon Van NevelOlga KryskoClaus BachertBert SchepensIne Lentacker et al.

A1 Journal Article in MOLECULAR THERAPY-NUCLEIC ACIDS

mRNA-based therapeutics to induce immunity against cancer and infectious diseases

Lien Van HoeckeXavier SaelensSandra Van LintKenny Roose

Next-generation sequencing : an eye-opener for the surveillance of antiviral resistance in influenza

Laura Van PoelvoordeXavier SaelensIsabelle ThomasNancy H Roosens

A1 Journal Article in TRENDS IN BIOTECHNOLOGY

Recombinant viruses delivering the necroptosis mediator MLKL induce a potent antitumor immunity in mice

Lien Van HoeckeStephanie RiedererXavier SaelensGerd SutterJuan Jose Rojas

A1 Journal Article in ONCOIMMUNOLOGY

Reverse engineering synthetic antiviral amyloids

Emiel MichielsKenny RooseRodrigo GallardoLadan KhodaparastLaleh KhodaparastRob van der KantMaxime SiemonsBert HoubenMeine RamakersHannah Wilkinson et al.

A1 Journal Article in NATURE COMMUNICATIONS

Selected IL-1 activity on CD8+ T cells allows for safe enhancement of cellular immune responses

Bram Van Den EeckhoutLien Van HoeckeElianne BurgSandra Van LintFrank PeelmanNiko KleyGilles UzéXavier SaelensJan TavernierSarah Gerlo

Specific targeting of IL-1β activity to CD8+ T cells allows for safe use as a vaccine adjuvant

Bram Van Den EeckhoutLien Van HoeckeElianne BurgSandra Van LintFrank PeelmanNiko KleyGilles UzéXavier SaelensJan TavernierSarah Gerlo

A1 Journal Article in NPJ VACCINES

STAT2 signaling restricts viral dissemination but drives severe pneumonia in SARS-CoV-2 infected hamsters

Robbert BoudewijnsHendrik Jan ThibautSuzanne J. F. KapteinRong LiValentijn VergoteLaura SeldeslachtsJohan Van WeyenberghCarolien De KeyzerLindsey BervoetsSapna Sharma et al.

A1 Journal Article in NATURE COMMUNICATIONS

Structural basis for potent neutralization of betacoronaviruses by single-domain camelid antibodies

Daniel WrappDorien De VliegerKizzmekia S. CorbettGretel M. TorresNianshuang WangWander Van BreedamKenny RooseLoes van SchieMarkus HoffmannStefan Poehlmann et al.

A1 Journal Article in CELL

Structural basis for potent neutralization of betacoronaviruses by single-domain camelid antibodies (vol 181, pg 1004, 2020)

Daniel WrappDorien De VliegerKizzmekia S. CorbettGretel M. TorresNianshuang WangWander Van BreedamKenny RooseLoes van SchieMarkus HoffmannStefan Pohlmann et al.

The involvement of viral and cellular proteins in the enigmatic feline coronavirus pathogenesis : a molecular and cell biology approach

Delphine AcarHans NauwynckXavier Saelens

The opposing effect of type I IFN on the T cell response by non-modified mRNA-lipoplex vaccines Is determined by the route of administration

Lien Van HoeckeKenny RooseMarlies BallegeerZifu ZhongNiek SandersStefaan De KokerXavier SaelensSandra Van Lint

A1 Journal Article in MOLECULAR THERAPY-NUCLEIC ACIDS

2019

A two-amino acid mutation in murine IgA enables downstream processing and purification on staphylococcal superantigen-like protein 7.

Shruti BakshiAnna DepickerBert SchepensXavier SaelensPaloma Juarez Ortega

A1 Journal Article in JOURNAL OF BIOTECHNOLOGY

Delivery of mixed-lineage kinase domain-like protein by vapor nanobubble photoporation induces necroptotic-like cell death in tumor cells

Lien Van HoeckeLaurens RaesStephan StremerschToon BransJuan FraireRia RoelandtWim DeclercqPeter VandenabeeleKoen RaemdonckKevin Braeckmans et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Engineering single domain antibodies into antivirals and vaccine delivery vehicles to combat infectious diseases

Shruti BakshiAnna DepickerXavier SaelensBert Schepens

Identification of peptide domains involved in the subcellular localization of the feline coronavirus 3b protein

Delphine AcarVeerle StroobantsHerman FavoreelXavier SaelensHans Nauwynck

A1 Journal Article in JOURNAL OF GENERAL VIROLOGY

Impact of M2e-specific monoclonal antibodies on influenza A virus spread in vitro and in a mouse transmission model

Annasaheb KolpeXavier SaelensBert Schepens

Intranodal administration of mRNA encoding nucleoprotein provides cross-strain immunity against influenza in mice

Patrick Tjok JoeIoanna ChristopoulouLien Van HoeckeBert SchepensTine YsenbaertCarlo HeirmanKris ThielemansXavier SaelensJoeri Aerts

A1 Journal Article in JOURNAL OF TRANSLATIONAL MEDICINE

Mx1 in hematopoietic cells protects against Thogoto virus infection

Jan SpitaelsLien Van HoeckeKenny RooseGeorg KochsXavier Saelens

A1 Journal Article in JOURNAL OF VIROLOGY

New antibody-based prevention and treatment options for influenza

Koen SedeynXavier Saelens

A1 Journal Article in ANTIVIRAL RESEARCH

Respiratory syncytial virus nonstructural proteins 1 and 2 : exceptional disrupters of innate immune responses

Koen SedeynBert SchepensXavier Saelens

A1 Journal Article in PLOS PATHOGENS

Selective engagement of FcγRIV by a M2e-specific single domain antibody construct protects against influenza A virus infection

Dorien De VliegerKatja HoffmannInge Van MolleWim NerinckxLien Van HoeckeMarlies BallegeerSarah CreytensHan RemautHartmut HengelBert Schepens et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Single domain-based antivirals to combat viral infections

Dorien De VliegerXavier SaelensBert Schepens

Super-resolution microscopy reveals significant impact of M2e-specific monoclonal antibodies on influenza A virus filament formation at the host cell surface

Annasaheb KolpeMaria Arista-RomeroBert SchepensSilvia PujalsXavier SaelensLorenzo Albertazzi

A1 Journal Article in SCIENTIFIC REPORTS

The role of matrix protein 2 ectodomain in the development of universal influenza vaccines

A1 Journal Article in JOURNAL OF INFECTIOUS DISEASES

TIV vaccination modulates host responses to influenza virus infection that correlate with protection against bacterial superinfection

Angela ChoiIoanna ChristopoulouXavier SaelensAdolfo García-SastreMichael Schotsaert

A1 Journal Article in VACCINES

Towards the use of interleukin-1β as vaccine adjuvant

Bram Van Den EeckhoutLien Van HoeckeElianne BurgSandra Van LintFrank PeelmanXavier SaelensJan TavernierSarah Gerlo

Vaccination with influenza hemagglutinin-loaded ceramic nanoporous microneedle arrays induces protective immune responses

Bert SchepensPieter Jan VosXavier SaelensKoen van der Maaden

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Vaccines against human respiratory syncytial virus in clinical trials, where are we now?

Iebe RosseyXavier Saelens

A1 Journal Article in EXPERT REVIEW OF VACCINES

Walter Fiers (1931-2019) : obituary

Wim DeclercqPeter VandenabeeleXavier Saelens

2018

A respiratory syncytial virus vaccine based on the small hydrophobic protein ectodomain presented with a novel lipid-based formulation is highly immunogenic and safe in adults : a first-in-humans study

Joanne M LangleyLisa D MacDonaldGenevieve M WeirDonna MacKinnon-CameronLingyun YeShelly McNeilBert SchepensXavier SaelensMarianne M StanfordScott A Halperin

A1 Journal Article in JOURNAL OF INFECTIOUS DISEASES

Antibodies directed toward neuraminidase N1 control disease in a mouse model of influenza

Emma JobMichael SchotsaertLorena IbanezAnouk SmetTine YsenbaertKenny RooseM. DaiC. A. M. de HaanH. KleanthousT. U. Vogel et al.

A1 Journal Article in JOURNAL OF VIROLOGY

Clinical potential of prefusion RSV F-specific antibodies

Iebe RosseyJason S McLellanXavier SaelensBert Schepens

A1 Journal Article in TRENDS IN MICROBIOLOGY

Determining the contribution of Mx1 in the antiviral immune cell compartement

Jan SpitaelsXavier SaelensKenny Roose

Host-RSV interactions : a siRNA and proteomics approach

Koen SedeynXavier SaelensBert Schepens

M2e-tetramer-specific memory CD4 T cells are broadly protective against influenza infection

D. G. EliassonA. OmokanyeK. SchönU. A. WenzelV. BernasconiM. BemarkAnnasaheb KolpeKarim El BakkouriTine YsenbaertLei Deng et al.

A1 Journal Article in MUCOSAL IMMUNOLOGY

Neutralization of Junín virus by single domain antibodies targeted against the nucleoprotein

Florencia LineroClaudia SepúlvedaIoanna ChristopoulouPaco HulpiauLuis ScolaroXavier Saelens

A1 Journal Article in SCIENTIFIC REPORTS

Passively transferred M2e-specific monoclonal antibody reduces influenza A virus transmission in mice

Annasaheb KolpeBert SchepensLiang YePeter StaeheliXavier Saelens

A1 Journal Article in ANTIVIRAL RESEARCH

Porous nanoparticles with self-adjuvanting M2e-fusion protein and recombinant hemagglutinin provide strong and broadly protective immunity against influenza virus infections

Valentina BernasconiBeatrice BernocchiLiang YeMinh Quan LêAjibola OmokanyeRodolphe CarpentierKarin SchönXavier SaelensPeter StaeheliDidier Betbeder et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Potent anti-viral vaccine adjuvant based on pH-degradable nanogels with covalently linked small molecule imidazoquinoline TLR7/8 agonist

Lutz NuhnLien Van HoeckeKim DeswarteBert SchepensYupeng LiBart LambrechtStefaan De KokerSunil A DavidXavier SaelensBruno De Geest

A1 Journal Article in BIOMATERIALS

Removal of the N-glycosylation sequon at position N116 located in p27 of the respiratory syncytial virus fusion protein elicits enhanced antibody responses after DNA immunization

Annelies LeemansMarlies BoerenWinke Van der GuchtIsabel PintelonKenny RooseBert SchepensXavier SaelensDalan BaileyWim MartinetGuy Caljon et al.

A1 Journal Article in VIRUSES-BASEL

Single-domain antibodies and their formatting to combat viral infections

Dorien De VliegerMarlies BallegeerIebe RosseyBert SchepensXavier Saelens

A2 Journal Article in ANTIBODIES

Species specificity of type III interferon activity and development of a sensitive luciferase-based bioassay for quantitation of mouse interferon-λ

Sophie JacobsFanny WavreilBert SchepensHans Henrik GadRune HartmannJoana Rocha-PereiraJohan NeytsXavier SaelensThomas Michiels

A1 Journal Article in JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Surfactant protein B (SP-B) enhances the cellular siRNA delivery of proteolipid coated nanogels for inhalation therapy

Pieterjan MerckxLynn De BackerLien Van HoeckeRoberta GuagliardoMercedes EchaidePieter BaatsenBárbara OlmedaXavier SaelensJésus Pérez-GilStefaan De Smedt et al.

A1 Journal Article in ACTA BIOMATERIALIA

Therapeutic anti-tumor immunity directed against neo-epitopes by intratumor delivery of mRNA encoding MLKL

Lien Van HoeckeXavier Saelens

A2 Journal Article in CELL STRESS

Transiently thermoresponsive acetal polymers for safe and effective administration of Amphotericin B as a vaccine adjuvant

Simon Van HerckLien Van HoeckeBenoit LouageLien LybaertRuben De CoenSabah KasmiAaron P Esser-KahnSunil A DavidLutz NuhnBert Schepens et al.

A1 Journal Article in BIOCONJUGATE CHEMISTRY

Treatment with mRNA coding for the necroptosis mediator MLKL induces antitumor immunity directed against neo-epitopes

Lien Van HoeckeSandra Van LintKenny RooseAlexander Van ParysPeter VandenabeeleJohan GrootenJan TavernierStefaan De KokerXavier Saelens

A1 Journal Article in NATURE COMMUNICATIONS

Vaccine options for influenza : thinking small

Bert SchepensDorien De VliegerXavier Saelens

A1 Journal Article in CURRENT OPINION IN IMMUNOLOGY

2017

A reassortant H9N2 influenza virus containing 2009 pandemic H1N1 internal-protein genes acquired enhanced pig-to-pig transmission after serial passages in swine

José Carlos Mancera GraciaSilvie Van den HoeckeJuergen A RichtWenjun MaXavier SaelensKristien Van Reeth

A1 Journal Article in SCIENTIFIC REPORTS

Bispecific T cell engaging antibody constructs targeting a universally conserved part of the viral M2 ectodomain cure and prevent influenza A virus infection

Jochen PendzialekKenny RooseAnouk SmetBert SchepensPeter KuferTobias RaumPatrick A BaeuerleMarkus MuenzXavier SaelensWalter Fiers

A1 Journal Article in ANTIVIRAL RESEARCH

Bronchoalveolar lavage of murine lungs to analyze inflammatory cell infiltration

Lien Van HoeckeEmma JobXavier SaelensKenny Roose

A1 Journal Article in JOVE-JOURNAL OF VISUALIZED EXPERIMENTS

Chemical-controlled activation of antiviral myxovirus resistance protein 1

Judith VerhelstLien Van HoeckeJan SpitaelsDorien De VliegerAnnasaheb KolpeXavier Saelens

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Effect of serial pig passages on the adaptation of an avian H9N2 influenza virus to swine

José Carlos Mancera GraciaSilvie Van den HoeckeXavier SaelensKristien Van Reeth

A1 Journal Article in PLOS ONE

Hierarchical and redundant roles of activating FcγRs in protection against influenza disease by M2e-specific IgG1 and IgG2a antibodies

Silvie Van den HoeckeKatrin EhrhardtAnnasaheb KolpeKarim El BakkouriLei DengHendrik GrootaertSteve SchoonoogheAnouk SmetMostafa BentahirKenny Roose et al.

A1 Journal Article in JOURNAL OF VIROLOGY

IgG3 snitcher of RSV infections in the very young

Bert SchepensXavier Saelens

Editorial material

Inflammatory monocytes regulate Th1 oriented immunity to CpG adjuvanted protein vaccines through production of IL-12

Stefaan De KokerLien Van HoeckeAns De BeuckelaerKenny RooseKim DeswarteMonique WillartPieter BogaertThomas NaessensBruno De GeestXavier Saelens et al.

A1 Journal Article in SCIENTIFIC REPORTS

M2-based influenza vaccines : recent advances and clinical potential

Annasaheb KolpeBert SchepensWalter FiersXavier Saelens

A1 Journal Article in EXPERT REVIEW OF VACCINES

Novel insights in the adaptation of avian H9N2 influenza viruses to swine

José Carlos Mancera GraciaKristien Van ReethXavier Saelens

Oral delivery of Escherichia coli persistently infected with M2e-displaying bacteriophages partially protects against influenza A virus

Lei DengKenny RooseEmma JobRiet De RyckeEvelien Van HammeAmanda GonçalvesEef ParthoensLaetitia CiccheleroNiek SandersWalter Fiers et al.

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

Potent single-domain antibodies that arrest respiratory syncytial virus fusion protein in its prefusion state

Iebe RosseyMorgan SA GilmanStephanie C KabecheKoen SedeynDaniel WrappMasaru KanekiyoMan ChenVicente MasJan SpitaelsJosé A Melero et al.

A1 Journal Article in NATURE COMMUNICATIONS

2016

A20 deficiency in lung epithelial cells protects against influenza A virus infection

Jonathan MaelfaitKenny RooseLars VereeckeConor Mc GuireMozes SzeMartijn SchuijsMonique WillartLorena IbanezHamida HammadBart Lambrecht et al.

A1 Journal Article in PLOS PATHOGENS

Crystal structure of the conserved amino terminus of the extracellular domain of matrix protein 2 of influenza A virus gripped by an antibody

Ki Joon ChoBert SchepensKristof MoonensLei DengWalter FiersHan RemautXavier Saelens

A1 Journal Article in JOURNAL OF VIROLOGY

Deep sequencing of influenza A viruses tempered by antibodies against the M2 ectodomain

Silvie Van den HoeckeXavier Saelens

GM-CSF treatment prevents respiratory syncytial virus– induced pulmonary exacerbation responses in postallergic mice by stimulating alveolar macrophage maturation

Thomas NaessensBert SchepensMuriel SmetCharlotte PollardLien Van HoeckeAns De BeuckelaerMonique WillartBart LambrechtStefaan De KokerXavier Saelens et al.

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Illumina MiSeq sequencing disfavours a sequence motif in the GFP reporter gene

Silvie Van den HoeckeJudith VerhelstXavier Saelens

A1 Journal Article in SCIENTIFIC REPORTS

Immuno-modulating properties of saliphenylhalamide, SNS-032, obatoclax, and gemcitabine

Sandra SöderholmMaria AnastasinaMohammad Majhural IslamJanne TynellMinna M PoranenDennis H BamfordJakob StenmanIlkka JulkunenIngrida ŠaulienėJef K De Brabander et al.

A1 Journal Article in ANTIVIRAL RESEARCH

Increased protein degradation improves influenza virus nucleoprotein-specific CD8⁺ T cell activation in vitro but not in C57BL/6 mice

Arwen F AltenburgCarolien E van de SandtStella E van TrierumHeidi LM De GruyterPeter RWA van RunRon AM FouchierKenny RooseXavier SaelensAsisa VolzGerd Sutter et al.

A1 Journal Article in JOURNAL OF VIROLOGY

Influenza-binding sialylated polymer coated gold nanoparticles prepared via RAFT polymerization and reductive amination

Zhiyue ZhangBert SchepensLutz NuhnXavier SaelensMichael SchotsaertNico CallewaertRiet De RyckeQilu ZhangSébastien MoinsSamira Benali et al.

A1 Journal Article in CHEMICAL COMMUNICATIONS

Inﬂuenza and memory T cells : how to awake the force

Jan SpitaelsKenny RooseXavier Saelens

A1 Journal Article in VACCINES

Long-lasting cross-protection against influenza A by neuraminidase and M2e-based immunization strategies

Michael SchotsaertTine YsenbaertAnouk SmetBert SchepensDieter VanderschaegheSvetlana StegalkinaThorsten U VogelNico CallewaertWalter FiersXavier Saelens

A1 Journal Article in SCIENTIFIC REPORTS

New antivirals against respiratory syncytial virus

Iebe RosseyXavier SaelensBert Schepens

One against all : a broadly influenza neutralizing man-made monoclonal antibody passes phase I

Editorial material

Optineurin deficiency in mice is associated with increased sensitivity to Salmonella but does not affect proinflammatory NF-κB signaling

Karolina SlowickaLars VereeckeConor Mc GuireMozes SzeJonathan MaelfaitAnnasaheb KolpeXavier SaelensRudi BeyaertGeert van Loo

A1 Journal Article in EUROPEAN JOURNAL OF IMMUNOLOGY

Phosphoproteomics to characterize host response during influenza A virus infection of human macrophages

Sandra SöderholmDenis E KainovTiina ÖhmanOxana V DenisovaBert SchepensEvgeny KulesskiySusumu Y ImanishiGarry CorthalsPetteri HintsanenTero Aittokallio et al.

A1 Journal Article in MOLECULAR & CELLULAR PROTEOMICS

Production and purification of recombinant filamentous bacteriophages displaying immunogenic heterologous epitopes

Lei DengFlorencia LineroXavier Saelens

Bookchapter in Vaccine design : methods and protocols, volume 2 : vaccines for veterinary diseases

Regulation of kynurenine biosynthesis during influenza virus infection

Lana GaelingsSandra SöderholmAndrii BugaiYu-Kui FuJatin NandaniaBert SchepensMartina B. LoreyJanne TynellLiesbeth Vande GinsteRonan Le Goffic et al.

A1 Journal Article in FEBS JOURNAL

Type I interferons interfere with the capacity of mRNA lipoplex vaccines to elicit cytolytic T cell responses

Ans De BeuckelaerCharlotte PollardSandra Van LintKenny RooseLien Van HoeckeTom NaessensVimal Kumar UdhayakumarMuriel SmetNiek SandersStefan Lienenklaus et al.

A1 Journal Article in MOLECULAR THERAPY

2015

A GFP expressing influenza A virus to report in vivo tropism and protection by a matrix protein 2 ectodomain-specific monoclonal antibody

Sarah De BaetsJudith VerhelstSilvie Van den HoeckeAnouk SmetMichael SchotsaertEmma JobKenny RooseBert SchepensWalter FiersXavier Saelens

A1 Journal Article in PLOS ONE

Analysis of the genetic diversity of influenza A viruses using next-generation DNA sequencing

Silvie Van den HoeckeJudith VerhelstMarnik VuylstekeXavier Saelens

A1 Journal Article in BMC GENOMICS

Co-immunoprecipitation of the mouse Mx1 protein with the influenza A virus nucleoprotein

Judith VerhelstDorien De VliegerXavier Saelens

A1 Journal Article in JOVE-JOURNAL OF VISUALIZED EXPERIMENTS

Comparison of the antiviral activity of Mus spretus Mx1 and Mus musculus A2G Mx1 against influenza A viruses

Judith VerhelstJan SpitaelsCindy NürnbergerDorien De VliegerTine YsenbaertPeter StaeheliWalter FiersXavier Saelens

Developing 3D SEM in a broad biological context

Anna KremerSaskia LippensSona BartunkovaBob AsselberghC BlanpainMatyas FendrychAlain GoossensM HoltSophie JanssensMichiel Krols et al.

A1 Journal Article in JOURNAL OF MICROSCOPY

Functional comparison of Mx1 from two different mouse species reveals the involvement of loop L4 in the antiviral activity against influenza A viruses

Judith VerhelstJan SpitaelsCindy NurnbergerDorien De VliegerTine YsenbaertPeter StaeheliWalter FiersXavier Saelens

A1 Journal Article in JOURNAL OF VIROLOGY

Influenza vaccines to control influenza-associated bacterial infection: where do we stand?

Ioanna ChristopoulouKenny RooseLorena IbanezXavier Saelens

A1 Journal Article in EXPERT REVIEW OF VACCINES

M2e-based universal influenza A vaccines

Lei DengKi Joon ChoWalter FiersXavier Saelens

A2 Journal Article in VACCINES

Protection against influenza A virus challenge with M2e-displaying filamentous Escherichia coli phages

Lei DengLorena IbanezVERONIQUE VAN DEN BOSSCHEKenny RooseSameh A YoussefAlain de BruinWalter FiersXavier Saelens

A1 Journal Article in PLOS ONE

Scop3D : three-dimensional visualization of sequence conservation

Tessa VermeireStijn VermaereBert SchepensXavier SaelensSteven Van GuchtLennart MartensElien Vandermarliere

A1 Journal Article in PROTEOMICS

Sequence-dependent internalization of aggregating peptides

José R CouceiroRodrigo GallardoFrederik De SmetGreet De BaetsPieter BaatsenWim AnnaertKenny RooseXavier SaelensJoost SchymkowitzFrederic Rousseau

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Small hydrophobic protein of respiratory syncytial virus as a novel vaccine antigen

Bert SchepensMichael SchotsaertXavier Saelens

Editorial material

Structure of the extracellular domain of matrix protein 2 of influenza A virus in complex with a protective monoclonal antibody

Ki Joon ChoBert SchepensJong Hyeon SeokSella KimKenny RooseJi-Hye LeeRodrigo GallardoEvelien Van HammeJoost SchymkowitzFrederic Rousseau et al.

A1 Journal Article in JOURNAL OF VIROLOGY

Targeted prokaryotic delivery of a conserved influenza A virus epitope for oral vaccination

Lei DengXavier Saelens

The C terminus of NS1 protein of influenza A/WSN/1933(H1N1) virus modulates antiviral responses in infected human macrophages and mice

Maria AnastasinaBert SchepensSandra SöderholmTuula A NymanSampsa MatikainenKalle SakselaXavier SaelensDenis E Kainov

A1 Journal Article in JOURNAL OF GENERAL VIROLOGY

2014

Akt inhibitor MK2206 prevents influenza pH1N1 virus infection in vitro

Oxana V DenisovaSandra SöderholmSalla VirtanenCarina Von SchantzDmitrii BychkovElena VashchinkinaJens DesloovereJanne TynellNiina IkonenLinda L Theisen et al.

A1 Journal Article in ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

CD8⁺ T cell immunity against human respiratory syncytial virus

Iebe RosseyKoen SedeynSarah De BaetsBert SchepensXavier Saelens

A1 Journal Article in VACCINE

Insight into highly conserved H1 subtype-specific epitopes in influenza virus hemagglutinin

Ki Joon ChoKwang W HongSe-Ho KimJong Hyeon SeokSella KimJi-Hye LeeXavier SaelensKyung Hyun Kim

A1 Journal Article in PLOS ONE

Metabolic profiling of insect cell lines: unveiling cell line determinants behind system's productivity

Francisca MonteiroVicente BernalXavier SaelensAna B LozanoCristina BernalAngel SevillaManuel JT CarrondoPaula M Alves

A1 Journal Article in BIOTECHNOLOGY AND BIOENGINEERING

Presenting heterologous epitopes with hepatitis B core-based virus-like particles

Sarah De BaetsKenny RooseBert SchepensXavier Saelens

Bookchapter in Virus-like particles in vaccine development

Protection and mechanism of action of a novel human respiratory syncytial virus vaccine candidate based on the extracellular domain of small hydrophobic protein

Bert SchepensKoen SedeynLiesbeth Vande GinsteSarah De BaetsMichael SchotsaertKenny RooseLieselot HouspieMarc Van RanstBarbara GilbertNico van Rooijen et al.

A1 Journal Article in EMBO MOLECULAR MEDICINE

Single-domain antibodies targeting neuraminidase protect against an H5N1 influenza virus challenge

Miguel Lopez CardosoLorena IbanezSilvie Van den HoeckeSarah De BaetsAnouk SmetKenny RooseBert SchepensFrancis DescampsWalter FiersSerge Muyldermans et al.

A1 Journal Article in JOURNAL OF VIROLOGY

2013

Anticancer compound ABT-263 accelerates apoptosis in virus-infected cells and imbalances cytokine production and lowers survival rates of infected mice

L KakkolaOV DenisovaJ TynellJ ViiliäinenTine YsenbaertRC MatosA NagarajT ÖhmanS KuivanenH Paavilainen et al.

A1 Journal Article in CELL DEATH & DISEASE

Antiviral activity of camelid single domain antibodies targeting the neuraminidase of H5N1 influenza virus

Miguel Lopez CardosoXavier SaelensAnna DepickerSerge Muyldermans

Challenges and advances towards the rational design of mRNA vaccines

Charlotte PollardStefaan De KokerXavier SaelensGuido VanhamJohan Grooten

A1 Journal Article in TRENDS IN MOLECULAR MEDICINE

Hepatitis B core-based virus-like particles to present heterologous epitopes

Kenny RooseSarah De BaetsBert SchepensXavier Saelens

A1 Journal Article in EXPERT REVIEW OF VACCINES

Immunogenicity of live attenuated B. pertussis BPZE1 producing the universal influenza vaccine candidate M2e

Hana KammounXavier RouxDominique RazeAnne-Sophie DebrieMarina De FiletteTine YsenbaertNathalie MielcarekXavier SaelensWalter FiersCamille Locht

A1 Journal Article in PLOS ONE

Insight into structural diversity of influenza virus haemagglutinin

Ki Joon ChoJi-Hye LeeKwang W HongSe-Ho KimYiho ParkJun Young LeeSeokha KangSella KimJi Hoon YangEui-Ki Kim et al.

A1 Journal Article in JOURNAL OF GENERAL VIROLOGY

M2e-displaying virus-like particles with associated RNA promote T helper 1 type adaptive immunity against influenza A

Lorena IbanezKenny RooseMarina De FiletteMichael SchotsaertJessica De SloovereStefan RoelsCharlotte PollardBert SchepensJohan GrootenWalter Fiers et al.

A1 Journal Article in PLOS ONE

Mx proteins: antiviral gatekeepers that restrain the uninvited

Judith VerhelstPaco HulpiauXavier Saelens

A1 Journal Article in MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Natural and long-lasting cellular immune responses against influenza in the M2e-immune host

Michael SchotsaertTine YsenbaertKristien NeytsLorena IbanezPieter BogaertBert SchepensBart LambrechtWalter FiersXavier Saelens

A1 Journal Article in MUCOSAL IMMUNOLOGY

Novel vaccination strategies against human respiratory syncytial virus

Sarah De BaetsXavier SaelensBert Schepens

Recombinant influenza virus carrying the respiratory syncytial virus (RSV) F85-93 CTL epitope reduces RSV replication in mice

Sarah De BaetsBert SchepensKoen SedeynMichael SchotsaertKenny RoosePieter BogaertWalter FiersXavier Saelens

A1 Journal Article in JOURNAL OF VIROLOGY

The Sin3a repressor complex regulates the balance between the activities of different STAT proteins

Laura IcardiRaffaele MoriViola GesellchenSven EyckermanJudith VerhelstKoen VercauterenXavier SaelensPhilip MeulemanKarolien De BosscherM Boutros et al.

2012

A20 (Tnfaip3) deficiency in myeloid cells protects against influenza A virus infection

Jonathan MaelfaitKenny RoosePieter BogaertMozes SzeXavier SaelensManolis PasparakisIsabelle CarpentierGeert van LooRudi Beyaert

A1 Journal Article in PLOS PATHOGENS

Cutting edge approaches towards novel and cross-protective influenza vaccines

Kenny RooseMichael SchotsaertKarim El BakkouriBert SchepensWalter FiersXavier Saelens

Bookchapter in Development of novel vaccines : skills, knowledge and translational technologies

Design and validation of novel cross-reactive influenza B vaccines

Kenny RooseXavier Saelens

Immunization with M2e-displaying T7 bacteriophage nanoparticles protects against Influenza A virus challenge

Hamidreza HashemiSomayeh PouyanfardMojgan BandehpourZahra NoroozbabaeiBahram KazemiXavier SaelensTalat Mokhtari-Azad

A1 Journal Article in PLOS ONE

Influenza vaccines: T-cell responses deserve more attention

Michael SchotsaertXavier SaelensGeert Leroux-Roels

A1 Journal Article in EXPERT REVIEW OF VACCINES

Interferon-inducible protein Mx1 inhibits influenza virus by interfering with functional viral ribonucleoprotein complex assembly

Judith VerhelstEef ParthoensBert SchepensWalter FiersXavier Saelens

A1 Journal Article in JOURNAL OF VIROLOGY

Obatoclax, saliphenylhalamide, and gemcitabine inhibit influenza A virus infection

Oxana V DenisovaLaura KakkolaLin FengJakob StenmanAshwin NagarajJohanna LampeBhagwan YadavTero AittokallioPasi KaukinenTero Ahola et al.

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Polymeric multilayer capsule-mediated vaccination induces protective immunity against cancer and viral infection

Bruno De GeestMonique WillartHamida HammadBart LambrechtCharlotte PollardPieter BogaertMarina De FiletteXavier SaelensChris VervaetJean Paul Remon et al.

A1 Journal Article in ACS NANO

Single domain camelid antibodies that neutralize negative strand viruses

Miguel Lopez CardosoLorena IbanezBert SchepensXavier Saelens

Bookchapter in Antiviral drugs : aspects of clinical use and recent advances

Tailor-made cleavage site attenuates influenza B

A1 Journal Article in EXPERT REVIEW OF VACCINES

The Sin3a repressor complex is a master regulator of STAT transcriptional activity

Laura IcardiRaffaele MoriViola GesellchenSven EyckermanLode De CauwerJudith VerhelstKoen VercauterenXavier SaelensPhilip MeulemanGeert Leroux-Roels et al.

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Unraveling the antiviral mechanism of mouse Mx1 directed against influenza A

Judith VerhelstXavier Saelens

2011

A novel non-toxic combined CTA1-DD and ISCOMS adjuvant vector for effective mucosal immunization against influenza virus

Dubravka Grdic EliassonAnja HelgebyKarin SchonCaroline NygrenKarim El BakkouriWalter FiersXavier SaelensKarin Bengtsson LovgrenIda NystromNils Y Lycke

A1 Journal Article in VACCINE

Antiserum against the conserved nine amino acid N-terminal peptide of influenza A virus matrix protein 2 is not immunoprotective

Marina De FiletteTine YsenbaertKenny RooseMichael SchotsaertStefan RoelsEls GoossensBert SchepensWalter FiersXavier Saelens

A1 Journal Article in JOURNAL OF GENERAL VIROLOGY

Assessment of the antiviral properties of recombinant porcine SP-D against various influenza A viruses in vitro

Marine LB HillaireMartin van EijkStella E van TrierumDebby van RielXavier SaelensRoland A RomijnWieger HemrikaRon AM FouchierThijs KuikenAlbert DME Osterhaus et al.

A1 Journal Article in PLOS ONE

Llama-derived single domain antibodies to build multivalent, superpotent and broadened neutralizing anti-viral molecules

Anna HultbergNigel J TempertonValérie RosseelsMireille KoendersMaria Gonzalez-PajueloBert SchepensLorena IbanezPeter VanlandschootJoris SchillemansMichael Saunders et al.

A1 Journal Article in PLOS ONE

Modulation of humoral and cellular immunity to influenza by vaccination

Michael SchotsaertXavier Saelens

Nanobodies with in vitro neutralizing activity protect mice against H5N1 influenza virus infection

Lorena IbanezMarina De FiletteAnna HultbergTheo VerripsNigel TempertonRobin A WeissWesley VandeveldeBert SchepensPeter VanlandschootXavier Saelens

A1 Journal Article in JOURNAL OF INFECTIOUS DISEASES

Nanobodies® specific for respiratory syncytial virus fusion protein protect against infection by inhibition of fusion

Bert SchepensLorena IbanezSarah De BaetsAnna HultbergPieter BogaertPieter De BleserFrederik VervalleTheo VerripsJose MeleroWesly Vandevelde et al.

A1 Journal Article in JOURNAL OF INFECTIOUS DISEASES

Nanobodies®: new ammunition to battle viruses

Peter VanlandschootCatelijne StortelersEls BeirnaertLorena IbanezBert SchepensErik DeplaXavier Saelens

A1 Journal Article in ANTIVIRAL RESEARCH

Protection against H5N1 influenza by immunoglobulin single variable domains

Lorena IbanezMarina De FiletteWesly VandeveldePeter VanlandschootXavier Saelens

A1 Journal Article in INFLUENZA AND OTHER RESPIRATORY VIRUSES

The proton translocation domain of cellular vacuolar ATPase provides a target for the treatment of influenza A virus infections

Konstantin H MüllerDenis E KainovKarim El BakkouriXavier SaelensJef K De BrabanderChristian KittelElisabeth SammClaude P Muller

A1 Journal Article in BRITISH JOURNAL OF PHARMACOLOGY

Universal vaccine based on ectodomain of matrix protein 2 of Influenza A: Fc receptors and alveolar macrophages mediate protection

Karim El BakkouriFrancis DescampsMarina De FiletteAnouk SmetEls FestjensAshley BirkettNico Van RooijenSjef VerbeekWalter FiersXavier Saelens

A1 Journal Article in JOURNAL OF IMMUNOLOGY

2010

Controlling influenza by cytotoxic T-cells : calling for help from destroyers

Michael SchotsaertLorena IbanezWalter FiersXavier Saelens

A1 Journal Article in JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Identification of polymorphisms in the ovine Shadow of prion protein (SPRN) gene and assessment of their effect on promoter activity and susceptibility for classical scrapie

Evelyne LampoLuc DuchateauBert SchepensMario Van PouckeXavier SaelensTim ErkensAlex Van ZeverenLuc Peelman

A1 Journal Article in Animal Genetics

Role of IFN-α during the acute stage of a swine influenza virus infection

Filip BarbéXavier SaelensDebby BraeckmansFrançois LefèvreKristien Van Reeth

A1 Journal Article in RESEARCH IN VETERINARY SCIENCE

The mitochondrial serine protease HtrA2/Omi cleaves RIP1 during apoptosis of Ba/F3 cells induced by growth factor withdrawal

Lieselotte Vande WalleEllen WirawanMohamed LamkanfiNele FestjensJelle VerspurtenXavier SaelensTom Vanden BerghePeter Vandenabeele

A1 Journal Article in CELL RESEARCH

2009

M2e-based universal influenza A vaccine

Walter FiersMarina De FiletteKarim El BakkouriBert SchepensKenny RooseMichael SchotsaertA BirkettXavier Saelens

A1 Journal Article in VACCINE

PANDEMIC PREPAREDNESS: TOWARD A UNIVERSAL INFLUENZA VACCINE

Kenny RooseWalter FiersXavier Saelens

A1 Journal Article in DRUG NEWS & PERSPECTIVES

Spray-dried powders of starch and crosslinked poly(acrylic acid) as carriers for nasal delivery of inactivated influenza vaccine

Delphine CouckeMichael SchotsaertClaude LibertEveline PringelsChris VervaetP ForemanXavier SaelensJean Paul Remon

A1 Journal Article in Vaccine

Universal M2 ectodomain-based influenza A vaccines: preclinical and clinical developments

Michael SchotsaertMarina De FiletteWalter FiersXavier Saelens

A1 Journal Article in EXPERT REVIEW OF VACCINES

2008

An influenza A vaccine based on tetrameric ectodomain of matrix protein 2

Marina De FiletteWouter MartensKenny RooseTom DerooFrederik VervalleMostafa BentahirJoël VandekerckhoveWalter FiersXavier Saelens

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

CTA1-M2e-DD: A novel mucosal adjuvant targeted influenza vaccine

DG ELIASSONKarim El BakkouriK SCHOENA RAMNEEls FestjensB LOWENADLERWalter FiersXavier SaelensN LYCKE

A1 Journal Article in VACCINE

The influenza matrix protein 2 as a vaccine target

A1 Journal Article in FUTURE VIROLOGY

Universal influenza A M2e-HBc vaccine protects against disease even in the presence of pre-existing anti-HBc antibodies

Marina De FiletteWouter MartensAnouk SmetMichael SchotsaertAshley BirkettPatricia Londoño-ArcilaWalter FiersXavier Saelens

A1 Journal Article in Vaccine

Vaccine development by recombinant DNA technology. Part I: DNA Vaccines

Amin BredanKenny RooseMichael SchotsaertXavier Saelens

Bookchapter in The Oea Review of Medicine

Vaccine development by recombinant DNA technology. Part II: Virus-like Particles

Amin BredanKenny RooseMichael SchotsaertXavier Saelens

Bookchapter in The Oea Review of Medicine

2007

Caspase-mediated cleavage of the exosome subunit PM/Scl-75 during apoptosis

G SCHILDERSR RAIJMAKERSKCR MALMEGRIMLieselotte Vande WalleXavier SaelensWV EGBERTSWJ VAN VENROOIJPeter VandenabeeleGJM PRUIJN

A1 Journal Article in ARTHRITIS RESEARCH & THERAPY

Proteome-wide identification of HtrA2/Omi substrates

Lieselotte Vande WallePetra Van DammeMohamed LamkanfiXavier SaelensJoël VandekerckhoveKris GevaertPeter Vandenabeele

A1 Journal Article in JOURNAL OF PROTEOME RESEARCH

The caspase-generated fragments of PKR cooperate to activate full-length PKR and inhibit translation

Michaël KalaiV SUINNele FestjensAnn MeeusA BERNISXM WANGXavier SaelensPeter Vandenabeele

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

2006

Butylated hydroxyanisole is more than a reactive oxygen species scavenger

Nele FestjensMichaël KalaiJoél SmetAnn MeeusRudy Van CosterXavier SaelensPeter Vandenabeele

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Improved design and intranasal delivery of an M2e-based human influenza A vaccine

Marina De FiletteWalter FiersWouter MartensA BIRKETTA RAMNEB LOWENADLERN LYCKEWM JOUXavier Saelens

A1 Journal Article in VACCINE

Necrosis is associated with IL-6 production but apoptosis is not

Tom Vanden BergheMichaël KalaiGeertrui DeneckerAnn MeeusXavier SaelensPeter Vandenabeele

A1 Journal Article in CELLULAR SIGNALLING

Role of mitochondrial proteins in apoptosis.

Xavier SaelensNele FestjensLieselotte Vande WallePeter Vandenabeele

Bookchapter in Apoptosis and cancer therapy

The universal influenza vaccine M2e-HBc administered intranasally in combination with the adjuvant CTA1-DD provides complete protection

Marina De FiletteA RAMNEA BIRKETTN LYCKEB LOWENADLERWM JOUXavier SaelensWalter Fiers

A1 Journal Article in VACCINE

2005

A novel caspase-2 complex containing TRAF2 and RIP1

Mohamed LamkanfiKathleen D'HondtLieselotte Vande WalleMaria (Marjan) van GurpGeertrui DeneckerJill DemeulemeesterMichaël KalaiWim DeclercqXavier SaelensPeter Vandenabeele

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Apoptosis of hematopoietic cells induced by growth factor withdrawal is associated with caspase-9 mediated cleavage of Raf-1

Sigrid CornelisYanik BruynoogheGeert van LooXavier SaelensPeter VandenabeeleRudi Beyaert

A1 Journal Article in ONCOGENE

Apoptotic pathways and their regulation

Greet BrouckaertMichaël KalaiXavier SaelensPeter Vandenabeele

Bookchapter in Apoptotic pathways as targets for novel therapies in cancer and other diseases

Fas induced necrosis.

Tom Vanden BergheNele FestjensMichaël KalaiXavier SaelensPeter Vandenabeele

Bookchapter in Fas Signaling

Mitochondria: Breathe or die

Lieselotte Vande WalleNele FestjensXavier SaelensPeter Vandenabeele

Bookchapter in Apoptosis

Protein synthesis persists during necrotic cell death

Xavier SaelensNele FestjensEef ParthoensIsabel VanoverbergheMichaël KalaiF VAN KUPPEVELDPeter Vandenabeele

A1 Journal Article in JOURNAL OF CELL BIOLOGY

2004

Caspase-1 activates nuclear factor of the kappa-enhancer in B cells independently of its enzymatic activity

Mohamed LamkanfiMichaël KalaiXavier SaelensWim DeclercqPeter Vandenabeele

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Differential signaling to apoptotic and necrotic cell death by Fas-associated death domain protein FADD

Tom Vanden BergheGeert van LooXavier SaelensMaria (Marjan) van GurpGreet BrouckaertMichaël KalaiWim DeclercqPeter Vandenabeele

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Doxorubicin-induced activation of protein kinase D1 through caspase-mediated proteolytic cleavage: identification of two cleavage sites by microsequencing

T VANTUSD VERTOMMENXavier SaelensA RYKXL DE KIMPES VANCAUWENBERGHS MIKHALAPE WAELKENSG KERIT SEUFFERLEIN et al.

A1 Journal Article in CELLULAR SIGNALLING

INCA, a novel human caspase recruitment domain protein that inhibits interleukin-1 beta generation

Mohamed LamkanfiGeertrui DeneckerMichaël KalaiKathleen D'HondtAnn MeeusWim DeclercqXavier SaelensPeter Vandenabeele

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Phagocytosis of necrotic cells by macrophages is phosphatidylserine dependent and does not induce inflammatory cytokine production

Greet BrouckaertMichaël KalaiDmitri KryskoXavier SaelensDominique VercammenMatladi NdlovuGuy HaegemanKatharina D'HerdePeter Vandenabeele

A1 Journal Article in MOLECULAR BIOLOGY OF THE CELL

The use of proteomics in the study of cell death

Xavier SaelensG VAN LOOKris GevaertJoël VandekerckhovePeter Vandenabeele

Bookchapter in When Cells Die II: A Comprehensive Evaluation of Apoptosis and Programmed Cell Death

Toxic proteins released from mitochondria in cell death

Xavier SaelensNele FestjensLieselotte Vande WalleMaria (Marjan) van GurpGeert van LooPeter Vandenabeele

A1 Journal Article in ONCOGENE

2003

A Bcl-2 transgene expressed in hepatocytes does not protect mice from fulminant liver destruction induced by Fas ligand

Geert van LooSaskia LippensM HAHNEFilip MatthijssensWim DeclercqXavier SaelensPeter Vandenabeele

A1 Journal Article in CYTOKINE

Bcl-2 family members as sentinels of cellular integrity and role of mitochondrial intermembrane space proteins in apoptotic cell death

Nele FestjensMaria (Marjan) van GurpGeert van LooXavier SaelensPeter Vandenabeele

A1 Journal Article in ACTA HAEMATOLOGICA

Caspase-mediated cleavage of the U snRNP-associated Sm-F protein during apoptosis

KCRM DE FARIASXavier SaelensGJM PRUIJNPeter VandenabeeleWJ VAN VENROOIJ

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Mitochondrial intermembrane proteins in cell death

Maria (Marjan) van GurpNele FestjensGeert van LooXavier SaelensPeter Vandenabeele

A1 Journal Article in BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Proteolysis of enteric cell villin by Entamoeba histolytica cysteine proteinases

Tineke LauwaetMaria José OliveiraBert CallewaertGeorges De BruyneXavier SaelensSerge AnkriPeter VandenabeeleDavid MirelmanMarcus MareelAncy Leroy

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

The caspase family

Mohamed LamkanfiWim DeclercqBart DepuydtMichaël KalaiXavier SaelensPeter Vandenabeele

Bookchapter in Caspases-Their Role in Cell Death and Cell Survival

Type II autophagic cell death and death-associated protein kinases

Xavier SaelensPeter Vandenabeele

A2 Journal Article in Chemtracts. Biochemistry and molecular biology

2002

Alice in caspase land. A phylogenetic analysis of caspases from worm to man.

Mohamed LamkanfiWim DeclercqMichaël KalaiXavier SaelensPeter Vandenabeele

Editorial material

Caspases are not localized in mitochondria during life or death

Geert van LooXavier SaelensFilip MatthijssensPeter SchotteRudi BeyaertWim DeclercqPeter Vandenabeele

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

The role of mitochondrial factors in apoptosis: a Russian roulette with more than one bullet.

Geert van LooXavier SaelensMaria (Marjan) van GurpM MACFARLANESJ MARTINPeter Vandenabeele

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Tipping the balance between necrosis and apoptosis in human and murine cells treated with interferon and dsRNA

Michaël KalaiGeert van LooTom Vanden BergheAnn MeeusWilhelmina BurmXavier SaelensPeter Vandenabeele

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

2001

Soluble recombinant influenza vaccines

Walter FiersSabine NeirynckTom DerooXavier SaelensWilly Min Jou

A1 Journal Article in PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES

Translation inhibition in apoptosis - Caspase-dependent PKR activation and eIF2-alpha phosphorylation.

Xavier SaelensMichaël KalaiPeter Vandenabeele

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Use of HDEL-tagged Trichoderma reesei mannosyl oligosaccharide 1,2-alpha-D-mannosidase for N-glycan engineering in Pichia pastoris.

Nico CallewaertWouter LaroyH CADIRGISteven GeysensXavier SaelensWilly Min JouRoland Contreras

A1 Journal Article in FEBS LETTERS

1999

A universal influenza A vaccine based on the extracellular domain of the M2 protein.

Sabine NeirynckTom DerooXavier SaelensP VANLANDSCHOOTWilly Min JouWalter Fiers

A1 Journal Article in NATURE MEDICINE

Protection of mice against a lethal influenza virus challenge after immunization with yeast-derived secreted influenza virus hemagglutinin.

Xavier SaelensP VANLANDSCHOOTWim MartinetMarleen MarasSabine NeirynckRoland ContrerasWalter FiersWilly Min Jou

A1 Journal Article in EUROPEAN JOURNAL OF BIOCHEMISTRY

1998

Evaluation of recombinant A/Victoria/3/75 (H3N2) influenza neuraminidase mutants as potential broad-spectrum subunit vaccines against influenza A.

Wim MartinetTom DerooXavier SaelensEls BeirnaertPeter VanlandschootRoland ContrerasWalter FiersWilly Min Jou

A1 Journal Article in ARCHIVES OF VIROLOGY

Modification of the protein glycosylation pathway in the methylotrophic yeast Pichia pastoris.

Wim MartinetMarleen MarasXavier SaelensWM JOURoland Contreras

A1 Journal Article in BIOTECHNOLOGY LETTERS

1997

In vitro conversion of the carbohydrate moiety of fungal glycoproteins to mammalian-type oligosaccharides - Evidence for N-acetylglucosaminyltransferase-I-accepting glycans from Trichoderma reesei.

Marleen MarasXavier SaelensWouter LaroyK PIENSMarc ClaeyssensWalter FiersRoland Contreras

A1 Journal Article in EUROPEAN JOURNAL OF BIOCHEMISTRY

Protection of mice against a lethal influenza challenge by immunization with yeast-derived recombinant influenza neuraminidase.

Wim MartinetXavier SaelensTom DerooSabine NeirynckRoland ContrerasWilly Min JouWalter Fiers

A1 Journal Article in EUROPEAN JOURNAL OF BIOCHEMISTRY

1996

Molecular and immunological characterization of soluble aggregated A/Victoria/3/75 (H3N2) influenza haemagglutinin expressed in insect cells.

Peter VanlandschootEls BeirnaertSabine NeirynckXavier SaelensWilly Min JouWalter Fiers

A1 Journal Article in ARCHIVES OF VIROLOGY

1995

A FAIRLY CONSERVED EPITOPE ON THE HEMAGGLUTININ OF INFLUENZA-A (H3N2) VIRUS WITH VARIABLE ACCESSIBILITY TO NEUTRALIZING ANTIBODY.

Peter VanlandschootEls BeirnaertS DEWILDEXavier SaelensT BESTEBROERJ DEJONGWilly Min JouWalter Fiers

A1 Journal Article in VIROLOGY

1991

Klonering, sekwentie-analyse en expressie van het RNA polymerasegen van het tabaksnecrose virus

Xavier SaelensWalter Fiers