Research Explorer

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Researcher

Wouter Van Overbeke

Awards & Distinctions

6 Results

2017

AAV9 delivered bispecific nanobody attenuates amyloid burden in the gelsolin amyloidosis mouse model

Adriaan VerhelleNair NishaInge EveraertWouter Van OverbekeLynn SupplyOlivier ZwaenepoelCindy PelemanJo Van DorpeTony LahoutteNick Devoogdt et al.

A1 Journal Article in HUMAN MOLECULAR GENETICS

2016

Non-invasive imaging of amyloid deposits in a mouse model of AGel using 99mTc-modified nanobodies and SPECT/CT

Adriaan VerhelleWouter Van OverbekeCindy PelemanRebecca De SmetOlivier ZwaenepoelTony LahoutteJo Van DorpeNick DevoogdtJan Gettemans

A1 Journal Article in MOLECULAR IMAGING AND BIOLOGY

2015

An ER-directed gelsolin nanobody targets the first step in amyloid formation in a gelsolin amyloidosis mouse model

Wouter Van OverbekeJantana WongsantichonInge EveraertAdriaan VerhelleOlivier ZwaenepoelAnantasak LoonchantaLeslie D BurtnickAriane De GanckTino HochepiedJody Haigh et al.

A1 Journal Article in HUMAN MOLECULAR GENETICS

Keeping mutant plasma gelsolin safe from harm: gelsolin nanobodies act as a chaperone against pathological proteolysis

Wouter Van OverbekeJan Gettemans

2014

Chaperone nanobodies protect gelsolin against MT1-MMP degradation and alleviate amyloid burden in the gelsolin amyloidosis mouse model

Wouter Van OverbekeAdriaan VerhelleInge EveraertOlivier ZwaenepoelJoël VandekerckhoveClaude CuvelierWim DeraveJan Gettemans

A1 Journal Article in MOLECULAR THERAPY

2010

Camelid single-domain antibodies as a therapeutic approach for familial amyloidosis of the Finnish type (FAF)

Wouter Van OverbekeM GuaraldoJoël VandekerckhoveAriane De GanckJan Gettemans