Research Explorer

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Researcher

Wim Vanden Berghe

Awards & Distinctions

91 Results

2024

Integrated assessment of the water systems of inhabited islands of the Galapagos

Lenin Riascos FloresPeter GoethalsChristine Van der heydenWim Vanden Berghe

2021

Marine seagrass extract of Thalassia testudinum suppresses colorectal tumor growth, motility and angiogenesis by autophagic stress and immunogenic cell death pathways

Ivones Hernández-BalmasedaIdania Rodeiro GuerraKen DeclerckJosé Alfredo Herrera IsidrónClaudina Pérez-NovoGuy Van CampOlivier De WeverKethia GonzálezMayrel LabradaAdriana Carr et al.

A1 Journal Article in MARINE DRUGS

2019

Water-soluble Withaferin A polymer prodrugs via a drug-functionalized RAFT CTA approach

Simon Van HerckBehrouz HassanniaBenoit LouageRaquel Pita CompostizoRuben De CoenWim Vanden BergheTom Vanden BergheBruno De Geest

A1 Journal Article in EUROPEAN POLYMER JOURNAL

2018

DNA-based monitoring of the alien invasive North American crayfish Procambarus clarkii in Andean lakes (Ecuador)

L. RiascosA. N. GeertsT. OñaPeter GoethalsJ. Cevallos-CevallosWim Vanden BergheF.A.M. VolckaertJ. BonillaK. MuylaertE. Velarde et al.

A1 Journal Article in LIMNOLOGICA

Nano-targeted induction of dual ferroptotic mechanisms eradicates high-risk neuroblastoma

Behrouz HassanniaBartosz WiernickiIrina IngoldFeng QuSimon Van HerckYulia Y. TyurinaHülya BayırBehnaz A. AbhariJose Pedro Friedmann AngeliSze Men Choi et al.

A1 Journal Article in JOURNAL OF CLINICAL INVESTIGATION

2017

Selective glucocorticoid receptor properties of GSK866 analogs with cysteine reactive warheads

Chandra S ChirumamillaAjay PalaganiBalu KamarajKen DeclerckMarinus WC VerbeekOksana RyabtsovaKarolien De BosscherNadia BougarneBart RuttensKris Gevaert et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Semi-synthetic sapogenin exerts neuroprotective effects by skewing the brain ischemia reperfusion transcriptome towards inflammatory resolution

Laura García-PupoJeney Ramírez SánchezDariusz RatmanClaudina Perez NovoKen DeclerckKarolien De BosscherMarios Nektarios MarkakisGerrit BeemsterArmando ZaldoYanier Nuñez Figueredo et al.

A1 Journal Article in BRAIN BEHAVIOR AND IMMUNITY

2016

Activation of the glucocorticoid receptor in acute inflammation : the SEDIGRAM concept

Karolien De BosscherIlse BeckDariusz RatmanWim Vanden BergheClaude Libert

A1 Journal Article in TRENDS IN PHARMACOLOGICAL SCIENCES

Ferroptosis : triggers, inhibitors and therapeutic potential in neuroblastoma

Behrouz HassanniaPeter VandenabeeleWim Vanden BergheTom Vanden Berghe

Selective glucocorticoid receptor-activating adjuvant therapy in cancer treatments

Nora SundahlDorien ClarisseMarc BrackeFritz OffnerWim Vanden BergheIlse Beck

A2 Journal Article in ONCOSCIENCE

2015

Inhibition of the NF-κB signaling pathway by a novel heterocyclic curcumin analogue

Anna-Maria KatsoriAjay PalaganiNadia BougarneDimitra Hadjipavlou-LitinaGuy HaegemanWim Vanden Berghe

A1 Journal Article in MOLECULES

2014

Dietary flavanols modulate the transcription of genes associated with cardiovascular pathology without changes in their DNA methylation state

Dragan MilenkovicWim Vanden BergheCéline BobyChristine LerouxKen DeclerckKatarzyna Szarc vel SzicKaren HeyninckKris LaukensMartin BizetMatthieu Defrance et al.

A1 Journal Article in PLOS ONE

Ectopic microRNA-150-5p transcription sensitizes glucocorticoid therapy response in MM1S multiple myeloma cells but fails to overcome hormone therapy resistance in MM1R cells

Ajay PalaganiKen Op de BeeckStefan NaulaertsJolien DiddensChandra Sekhar ChirumamillaGuy Van CampKris LaukensKaren HeyninckSarah GerloPieter Mestdagh et al.

A1 Journal Article in PLOS ONE

Inhibition of corticosteroid-binding globulin gene expression by glucocorticoids involves C/EBPβ

Nicolette VerhoogFatima Allie-ReidWim Vanden BergheCarine SmithGuy HaegemanJanet HapgoodAnn Louw

A1 Journal Article in PLOS ONE

SNP-guided identification of monoallelic DNA-methylation events from enrichment-based sequencing data

Sandra SteyaertWim Van CriekingeAyla De PaepeSimon DenilKlaas MensaertKatrien VandepitteWim Vanden BergheGeert TrooskensTim De Meyer

A1 Journal Article in NUCLEIC ACIDS RESEARCH

Selective modulation of the glucocorticoid receptor can distinguish between transrepression of NF-κB and AP-1

Karolien De BosscherIlse BeckLien DejagerNadia BougarneAnthoula GaigneauxSebastien ChateauvieuxDariusz RatmanMarc BrackeJan TavernierWim Vanden Berghe et al.

A1 Journal Article in CELLULAR AND MOLECULAR LIFE SCIENCES

Withaferin A inhibits NF-kappaB activation by targeting cysteine 179 in IKKβ

Karen HeyninckMaija Lahtela-KakkonenPieter Van der VekenGuy HaegemanWim Vanden Berghe

A1 Journal Article in BIOCHEMICAL PHARMACOLOGY

2013

How glucocorticoid receptors modulate the activity of other transcription factors: a scope beyond tethering

Dariusz RatmanWim Vanden BergheLien DejagerClaude LibertJan TavernierIlse BeckKarolien De Bosscher

A1 Journal Article in MOLECULAR AND CELLULAR ENDOCRINOLOGY

Modulation of Nrf2-KEAP1 signaling by the natural compound Withaferin A: potential therapeutic effect in cardiovascular diseases?

Linde SabbeWim Vanden BergheKaren HeyninckGuy Haegeman

Safe TNF-based antitumor therapy following p55TNFR reduction in intestinal epithelium

Filip Van HauwermeirenMarietta ArmakaNiki KaragianniKsanthi KranidiotiRoosmarijn VandenbrouckeSonja LogesMaarten Van RoyenJan StaelensLeen PuimègeAjay Palagani et al.

A1 Journal Article in JOURNAL OF CLINICAL INVESTIGATION

2012

Dietary curcumin inhibits atherosclerosis by affecting the expression of genes involved in leukocyte adhesion and transendothelial migration

Dilek CobanDragan MilenkovicAudrey ChanetJamila Khallou-LaschetLinde SabbeAjay PalaganiWim Vanden BergheAndrzej MazurChristine Morand

A1 Journal Article in MOLECULAR NUTRITION & FOOD RESEARCH

Epigenetic impact of dietary polyphenols in cancer chemoprevention: lifelong remodeling of our epigenomes

Wim Vanden Berghe

A1 Journal Article in PHARMACOLOGICAL RESEARCH

Flavanols modulate the transcription of genes involved in cardiovascular pathology with heterogenic changes of their DNA methylation state: FLAVIOLA associated

Antje R WeselerDragan MilenkovicWim Vanden BergheErik JB RuijtersKaren HeyninckFrançois FuksGuy HaegemanGuido RMM HaenenAalt Bast

Flavanols: what do we know about their mechanisms of action?

Aalt BastSylvain ClaudeGuy HaegemanGuido RMM HaenenChristian HeissKaren HeyninckMarc MerxDragan MilenkovicChristine MorandErik JB Ruijters et al.

Molecular insight in the multifunctional activities of Withaferin A

Wim Vanden BergheLinde SabbeMary KailehGuy HaegemanKaren Heyninck

A1 Journal Article in BIOCHEMICAL PHARMACOLOGY

2011

Families of choice? Exploring the supportive networks of lesbians, gay men, and bisexuals

Alexis DewaeleNele CoxWim Vanden BergheJohny Vincke

A1 Journal Article in JOURNAL OF APPLIED SOCIAL PSYCHOLOGY

Gallic acid indanone and mangiferin xanthone are strong determinants of immunosuppressive anti-tumour effects of Mangifera indica L. bark in MDA-MB231 breast cancer cells

Dagmar Garcia-RiveraRene DelgadoNadia BougarneGuy HaegemanWim Vanden Berghe

A1 Journal Article in CANCER LETTERS

Phytochemicals and cancer chemoprevention: epigenetic friends or foe?

Katarzina Szarc vel SzicAjay PalaganiBehrouz HassanniaLinde SabbeKaren HeyninckGuy HaegemanWim Vanden Berghe

Bookchapter in Phytochemicals : bioactivities and impact on health

2010

Abrogation of glucocorticoid receptor dimerization correlates with dissociated glucocorticoid behavior of compound A

Steven RobertsonFatima Allie-ReidWim Vanden BergheKoch VisserAnke BinderDonita AfricanderMichael VismerKarolien De BosscherJanet HapgoodGuy Haegeman et al.

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Differential chemosensitization of P-glycoprotein overexpressing K562/Adr cells by withaferin A and Siamois polyphenols

Wipob SuttanaSamlee MankhetkornWilart PoompimonAjay PalaganiSergey ZhokhovSarah GerloGuy HaegemanWim Vanden Berghe

A1 Journal Article in MOLECULAR CANCER

Direct and transgenerational impact on Daphnia magna of chemicals with a known effect on DNA methylation

Michiel VandegehuchteFilip LemièreLynn VanhaeckeWim Vanden BergheColin Janssen

A1 Journal Article in COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY

Epigenetic remedies by dietary phytochemicals against inflammatory skin disorders: myth or reality?

Wim Vanden BergheGuy Haegeman

A1 Journal Article in CURRENT DRUG METABOLISM

Minority specific determinants of mental well-being among lesbian, gay and bisexual youth

Wim Vanden BergheAlexis DewaeleNele CoxJohny Vincke

A1 Journal Article in JOURNAL OF APPLIED SOCIAL PSYCHOLOGY

Nature or nurture: let food be your epigenetic medicine in chronic inflammatory disorders

Katarzyna Szarc Vel SzicMatladi N NdlovuGuy HaegemanWim Vanden Berghe

A1 Journal Article in BIOCHEMICAL PHARMACOLOGY

2009

Crosstalk in inflammation: the interplay of glucocorticoid receptor-based mechanisms and kinases and phosphatases

Ilse BeckWim Vanden BergheLinda VermeulenKeith R YamamotoGuy HaegemanKarolien De Bosscher

A1 Journal Article in ENDOCRINE REVIEWS

Glucocorticoids and mitogen- and stress-activated protein kinase 1 inhibitors: Possible partners in the combat against inflammation

Ilse BeckWim Vanden BergheSarah GerloNadia BougarneLinda VermeulenKarolien De BosscherGuy Haegeman

A1 Journal Article in BIOCHEMICAL PHARMACOLOGY

Hyperactivated NF-κB and AP-1 transcription factors promote highly accessible chromatin and constitutive transcription across the interleukin-6 gene promoter in metastatic breast cancer cells

Matladi N NdlovuCarine Van LintKarlien Van WesemaelPieter CallebertDany ChalbosGuy HaegemanWim Vanden Berghe

A1 Journal Article in MOLECULAR AND CELLULAR BIOLOGY

TLR4-mediated IL-6 gene expression in macrophages : who does the job?

Sarah GerloAnneleen SpoorenAgatha KoreckaGuy HaegemanWim Vanden Berghe

The intracellular targets and anticancer mechanisms of Siamois® polyphenols

Wipob SuttanaSamlee MankhetkornGuy HaegemanWim Vanden BergheManuel Garrigos

The versatile role of MSKs in transcriptional regulation

Linda VermeulenWim Vanden BergheIlse BeckKarolien De BosscherGuy Haegeman

A1 Journal Article in TRENDS IN BIOCHEMICAL SCIENCES

Xanthohumol activates the proapoptotic arm of the unfolded protein response in chronic lymphocytic leukemia

Sofie LustBarbara VanhoeckeMireille Van GeleJerina BoelensHeleen Van MelckebekeMary KailehWim Vanden BergheGuy HaegemanJan PhilippéMarc Bracke et al.

A1 Journal Article in ANTICANCER RESEARCH

2008

A plant-derived ligand favoring monomeric glucocorticoid receptor conformation with impaired transactivation potential attenuates collagen-induced arthritis

Pieter DewintValerie GossyeKarolien De BosscherWim Vanden BergheKatrien Van BenedenDieter DeforceSerge Van CalenberghU MULLER-LADNERBert Vander CruyssenAugust Verbruggen et al.

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Altered subcellular distribution of MSK1 induced by glucocorticoids contributes to NF-kappa B inhibition

Ilse BeckWim Vanden BergheLinda VermeulenNadia BougarneBERT VANDER CRUYSSENGuy HaegemanKarolien De Bosscher

A1 Journal Article in EMBO JOURNAL

Beneficial effects of soy isoflavones Focus on epigenetic and anti-inflammatory effects

Wim Vanden BergheGuy Haegeman

A1 Journal Article in AGRO FOOD INDUSTRY HI-TECH

Transcriptional regulation of autocrine IL-6 expression in multiple myeloma cells

Sarah GerloGuy HaegemanWim Vanden Berghe

A1 Journal Article in CELLULAR SIGNALLING

2007

A critical role for p53 in the control of NF-kappa B-dependent gene expression in TLR4-stimulated dendritic cells exposed to genistein

Nathalie DijsselbloemS GORIELYV ALBARANISarah GerloSarah FrancozJean-Christophe MarineM GOLDMANGuy HaegemanWim Vanden Berghe

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Contribution of IKK and PKA pathways to TLR4-triggered chromatin relaxation and transcription of the IL-6 gene

Sarah GerloWim Vanden BergheGuy Haegeman

Deguelin inhibits expression of I kappa B alpha protein and induces apoptosis of B-CLL cells in vitro

Ben GeeraertsBarbara VanhoeckeWim Vanden BergheJan PhilippéFritz OffnerDieter Deforce

A1 Journal Article in LEUKEMIA

Estrogen receptor signaling is an unstable feature of the gonadotropic LβT2 cell line

F EertmansWillem DhoogeOlivier De WeverWim Vanden BergheVeerle BogaertMarc BrackeGuy HaegemanFrank ComhaireJean Kaufman

A1 Journal Article in MOLECULAR AND CELLULAR ENDOCRINOLOGY

Histone deacetylase inhibitor trichostatin A sustains sodium pervanadate-induced NF-kappa B activation by delaying I kappa B alpha mRNA resynthesis - Comparison with tumor necrosis factor alpha

J HORIONG GLOIREN EL MJIYADV QUIVYLinda VermeulenWim Vanden BergheGuy HaegemanC VAN LINTJ PIETTEY HABRAKEN

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Methylglyoxal suppresses TNF-alpha-induced NF-kappa B activation by inhibiting NF-kappa B DNA-binding

Mathias LagaAnneleen CottynFranky Van HerrewegheWim Vanden BergheGuy HaegemanPatric Van OostveldtJoël VandekerckhoveKatia Vancompernolle

A1 Journal Article in BIOCHEMICAL PHARMACOLOGY

Preclinical study of a novel, non-steroidal, plant-derived, anti-inflammatory compound for the treatment of airway disease

Philippe GevaertJoke PatouThibaut Van ZeleGabriële HoltappelsKarolien De BosscherWim Vanden BergheGuy HaegemanClaus Bachert

Screening of indigenous Palestinian medicinal plants for potential anti-inflammatory and cytotoxic activity

Mary KailehWim Vanden BergheElke BooneT ESSAWIGuy Haegeman

A1 Journal Article in JOURNAL OF ETHNOPHARMACOLOGY

Withaferin A strongly elicits I kappa B kinase beta hyperphosphorylation concomitant with potent inhibition of its kinase activity

Mary KailehWim Vanden BergheArne HeyerickJ HORIONJ PIETTEClaude LibertDenis De KeukeleireT ESSAWIGuy Haegeman

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Xanthohumol induces in vitro apoptosis in B-CLL cells mediated by non-classical ER stress

Sofie LustBarbara VanhoeckeMireille Van GeleJerina BoelensMary KailehWim Vanden BergheJ PHILLIPESMarc BrackeFritz Offner

2006

Attenuation of mitogen- and stress-activated protein kinase-1-driven nuclear factor-kappa B gene expression by soy isoflavones does not require estrogenic activity

Wim Vanden BergheNathalie DijsselbloemLinda VermeulenMatladi NdlovuElke BooneGuy Haegeman

A1 Journal Article in CANCER RESEARCH

Cross-talk between nuclear receptors and nuclear factor kappa B

Karolien De BosscherWim Vanden BergheGuy Haegeman

A1 Journal Article in ONCOGENE

Keeping up NF-kappa B appearances: Epigenetic control of immunity or inflammation-triggered epigenetics

Wim Vanden BergheMatladi NdlovuR. HOYA-ARIASNathalie DijsselbloemSarah GerloGuy Haegeman

A1 Journal Article in BIOCHEMICAL PHARMACOLOGY

Regulation of NF-kappaB transcriptional activity

Linda VermeulenWim Vanden BergheGuy Haegeman

Bookchapter in The Link Between Inflammation and Cancer: Wounds that do not heal

2005

A fully dissociated compound of plant origin for inflammatory gene repression

Karolien De BosscherWim Vanden BergheIlse BeckWim Van MolleN HENNUYERJ HAPGOODClaude LibertB STAELSA LOUWGuy Haegeman

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Baseline nucleophosmin status in mutated(M) versus unmutated(U) immunoglobulin B-CLL is a nuclear reflection of different signal transduction physiology

Jerina BoelensWim Vanden BergheGuy HaegemanAnne JanssensJan PhilippéFritz Offner

Inhibition of phosphoinositide 3-kinase enhances TRIF-dependent NF-kappa B activation and IFN-beta synthesis downstream of Toll-like receptor 3 and 4

E AKSOYWim Vanden BergheS DETIENNEZ AMRAOUIKA FITZGERALDGuy HaegemanM GOLDMANF WILLEMS

A1 Journal Article in EUROPEAN JOURNAL OF IMMUNOLOGY

NF-kappa B mediated IL-6 production by renal epithelial cells is regulated by C-Jun NH2-terminal kinase

S DE HAIJAC BAKKERRN VAN DER GEESTGuy HaegemanWim Vanden BergheJ AARBIOUMR DAHAC VAN KOOTEN

A1 Journal Article in JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Potent anti-inflammatory, fully dissociative compound for glucocorticoid receptor-mediated gene regulation

Pieter DewintKarolien De BosscherValerie GossyeWim Vanden BergheBert Vander CruyssenEric VeysGuy HaegemanDirk Elewaut

Regulation of NF-kappaB-driven inflammatory genes by phytoestrogens

Wim Vanden BergheN. DIJSSELBLOEMAn De NaeyerLinda VermeulenGuy Haegeman

Bookchapter in Oxidative stress, Inflammation and Health

Role of glucocorticoids in dopamine-related neuropsychiatric disorders

Kathleen Van CraenenbroeckKarolien De BosscherWim Vanden BerghePeter VanhoenackerGuy Haegeman

A1 Journal Article in MOLECULAR AND CELLULAR ENDOCRINOLOGY

2004

Estrogenic and anticarcinogenic properties of kurarinone, a lavandulyl flavanone from the roots of Sophora flavescens

An De NaeyerWim Vanden BergheV POCOCKS MILLIGANGuy HaegemanDenis De Keukeleire

A1 Journal Article in JOURNAL OF NATURAL PRODUCTS

Medroxyprogesterone acetate downregulates cytokine gene expression in mouse fibroblast cells

D KOUBOVECWim Vanden BergheLinda VermeulenGuy HaegemanJP HAPGOOD

A1 Journal Article in MOLECULAR AND CELLULAR ENDOCRINOLOGY

Soy isoflavone phyto-pharmaceuticals in interleukin-6 affections multi-purpose nutraceuticals at the crossroad of hormone replacement, anti-cancer and anti-inflammatory therapy

Nathalie DijsselbloemWim Vanden BergheAn De NaeyerGuy Haegeman

A1 Journal Article in BIOCHEMICAL PHARMACOLOGY

2003

A paradigm for gene regulation: Inflammation, NF-kappa B and PPAR

Wim Vanden BergheLinda VermeulenP DELERIVEKarolien De BosscherB STAELSGuy Haegeman

A1 Journal Article in PEROXISOMAL DISORDERS AND REGULATION OF GENES

Inhibition of cytokine production by the herbicide atrazine - Search for nuclear receptor targets

S DEVOSKarolien De BosscherB STAELSE BAUERFrank RoelsWim Vanden BergheGuy HaegemanR HOOGHEEL HOOGHE-PETERS

A1 Journal Article in BIOCHEMICAL PHARMACOLOGY

Regulation of NF-kB by glucocorticoids

Karolien De BosscherWim Vanden BergheGuy Haegeman

Bookchapter in Nuclear Factor kB: Regulation and role in disease

Regulation of prolactin expression in leukemic cell lines and peripheral blood mononuclear cells

Sarah GerloWim Vanden BergheP VerdoodEL Hooghe-PetersR Kooijman

A1 Journal Article in JOURNAL OF NEUROIMMUNOLOGY

The interplay between the glucocorticoid receptor and nuclear factor-kappa B or activator protein-1: Molecular mechanisms for gene repression

Karolien De BosscherWim Vanden BergheGuy Haegeman

A1 Journal Article in ENDOCRINE REVIEWS

Transcriptional activation of the NF-kappa B p65 subunit by mitogen- and stress-activated protein kinase-1 (MSK1)

Linda VermeulenGert De WildePetra Van DammeWim Vanden BergheGuy Haegeman

A1 Journal Article in EMBO JOURNAL

2002

DNA binding-independent induction of I kappa B alpha gene transcription by PPAR alpha

P DeleriveKarolien De BosscherWim Vanden BergheJC FruchartGuy HaegemanB Staels

A1 Journal Article in MOLECULAR ENDOCRINOLOGY

Induction and repression of NF-kappaB-driven inflammatory genes.

Wim Vanden BergheKarolien De BosscherLinda VermeulenGert De WildeGuy Haegeman

Bookchapter in Recent Advances in Glucocorticoid Receptor Action

Regulation of the transcriptional activity of the nuclear factor-kappa B p65 subunit.

Linda VermeulenGert De WildeSofie NotebaertWim Vanden BergheGuy Haegeman

A1 Journal Article in BIOCHEMICAL PHARMACOLOGY

2001

Glucocorticoid repression of AP-1 is not mediated by competition for nuclear coactivators.

Karolien De BosscherWim Vanden BergheGuy Haegeman

A1 Journal Article in MOLECULAR ENDOCRINOLOGY

2000

Signal transduction by tumor necrosis factor and gene regulation of the inflammatory cytokine interleukin-6.

Wim Vanden BergheLinda VermeulenGert De WildeKarolien De BosscherElke BooneGuy Haegeman

A1 Journal Article in BIOCHEMICAL PHARMACOLOGY

1999

Dissociated glucocorticoids with anti-inflammatory potential repress interleukin-6 gene expression by a nuclear factor-kappa B-dependent mechanism.

Wim Vanden BergheE FRANCESCONIKarolien De BosscherM RESCHE-RIGONGuy Haegeman

A1 Journal Article in MOLECULAR PHARMACOLOGY

In search of the molecular mechanism of gene repression by glucocorticoids

Karolien De BosscherWim Vanden BergheElke BooneGuy Haegeman

In search of the molecular mechanism of gene repression by glucocorticoids.

Karolien De BosscherWim Vanden BergheElke BooneGuy Haegeman

N-acetyl-L-cysteine inhibits primary human T cell responses at the dendritic cell level: Association with NF-kappa B inhibition.

V VERHASSELTWim Vanden BergheN VANDERHEYDEFrans WillemsGuy HaegemanM GOLDMAN

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Peroxisome proliferator-activated receptor alpha negatively regulates the vascular inflammatory gene response by negative cross-talk with transcription factors NF-kappa B and AP-1.

P DELERIVEKarolien De BosscherS BESNARDWim Vanden BergheJM PETERSFJ GONZALEZJC FRUCHARTA TEDGUIGuy HaegemanB STAELS

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

The nuclear factor-kappa B engages CBP/p300 and histone acetyltransferase activity for transcriptional activation of the interleukin-6 gene promoter.

Wim Vanden BergheKarolien De BosscherElke BooneS PLAISANCEGuy Haegeman

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

The zinc finger protein A20 inhibits TNF-induced NF-kappa B-dependent gene expression by interfering with an RIP- or TRAF2-mediated transactivation signal and directly binds to a novel NF-kappa B-inhibiting protein ABIN.

Karen HeyninckDirk De ValckWim Vanden BergheWim Van CriekingeRoland ContrerasWalther FiersGuy HaegemanRudi Beyaert

A1 Journal Article in JOURNAL OF CELL BIOLOGY

1998

p38 and extracellular signal-regulated kinase mitogen-activated protein kinase pathways are required for nuclear factor kappa B p65 transactivation mediated by tumor necrosis factor.

Wim Vanden BergheS PLAISANCEElke BooneKarolien De BosscherML SCHMITZWalther FiersGuy Haegeman

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

1997

Glucocorticoid-mediated repression of nuclear factor-κB-dependent transcription involves direct interference with transactivation

Karolien De BosscherM Lienhard SchmitzWim Vanden BergheStéphane PlaisanceWalther FiersGuy Haegeman

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tumour necrosis factor: intracellular mechanism of action

Walther FiersRudi BeyaertElke BooneWim DeclercqEls DecosterDirk De ValckVera GoossensJohan GrootenGuy HaegemanKaren Heyninck et al.

Bookchapter in HIV and cytokines

1993

Studies on the inducibility of the IL6 promoter using a reporter gene construction.

Wim Vanden BergheGuy HaegemanWalther Fiers