Research Explorer

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Researcher

Wim Nerinckx

Awards & Distinctions

46 Results

2025

Single-domain antibodies directed against hemagglutinin and neuraminidase protect against influenza B viruses

Arne MatthysJan FélixJoão Portela CataniKenny RooseWim NerinckxBenthe Van BuytenDaria FijalkowskaNico CallewaertSavvas SavvidesXavier Saelens

U Journal Article in NATURE COMMUNICATIONS

Ultrapotent SARS coronavirus-neutralizing single-domain antibodies that clamp the spike at its base

Sieglinde De CaeInge Van MolleLoes van SchieSophie R. ShoemakerJulie DeckersNincy DebeufSahine LameireWim NerinckxKenny RooseDaria Fijalkowska et al.

U Journal Article in NATURE COMMUNICATIONS

2023

GlycoVHH : optimal sites for introducing N-glycans on the camelid VHH antibody scaffold and use for macrophage delivery

Loes van SchieWander Van BreedamCharlotte RoelsBert SchepensMartin FrankAhmadreza MehdipourBram LaukensWim NerinckxFrancis SantensSimon Devos et al.

A1 Journal Article in MABS

2022

GlycoVHH : introducing N-glycans on the camelid VHH antibody scaffold : optimal sites and use for macrophage delivery

Loes van SchieWander Van BreedamCharlotte RoelsBert SchepensMartin FrankAhmadreza MehdipourBram LaukensWim NerinckxFrancis SantensSimon Devos et al.

2021

An affinity-enhanced, broadly neutralizing heavy chain-only antibody protects against SARS-CoV-2 infection in animal models

Bert SchepensLoes van SchieWim NerinckxKenny RooseWander Van BreedamDaria FijalkowskaSimon DevosWannes WeytsSieglinde De CaeSandrine Vanmarcke et al.

A1 Journal Article in SCIENCE TRANSLATIONAL MEDICINE

2019

Disruption of endocytosis through chemical inhibition of clathrin heavy chain function

Wim DejongheIsha SharmaBram DenooSteven De MunckQing LuKiril MishevHaydar BulutEvelien MylleRiet De RyckeMina Vasileva et al.

A1 Journal Article in NATURE CHEMICAL BIOLOGY

Selective engagement of FcγRIV by a M2e-specific single domain antibody construct protects against influenza A virus infection

Dorien De VliegerKatja HoffmannInge Van MolleWim NerinckxLien Van HoeckeMarlies BallegeerSarah CreytensHan RemautHartmut HengelBert Schepens et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

2018

Nonselective chemical inhibition of Sec7 domain-containing ARF GTPase exchange factors

Kiril MishevQing LuBram DenooFrancois PeuroisWim DejongheJan HullaertRiet De RyckeSjef BoerenMarine BretouSteven De Munck et al.

A1 Journal Article in PLANT CELL

The inhibitor endosidin 4 targets SEC7 domain-type ARF GTPase exchange factors and interferes with subcellular trafficking in eukaryotes

Urszula KaniaTomasz NodzyńskiQing LuGlenn R. HicksWim NerinckxKiril MishevFrancois PeuroisJacqueline CherfilsRiet De RyckePeter Grones et al.

A1 Journal Article in PLANT CELL

Tozasertib analogues as inhibitors of necroptotic cell death

Sam HofmansLars DevisscherSofie MartensDries Van RompaeyKenneth GoossensTatyana DivertWim NerinckxNozomi TakahashiHans De WinterPieter Van der Veken et al.

A1 Journal Article in JOURNAL OF MEDICINAL CHEMISTRY

2017

When PERK inhibitors turn out to be new potent RIPK1 inhibitors : critical issues on the specificity and use of GSK2606414 and GSK2656157

Diego Rojas RiveraTinneke DelvaeyeRia RoelandtWim NerinckxKoen AugustynsPeter VandenabeeleMathieu Bertrand

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

2012

A bacterial glycosidase enables mannose-6-phosphate modification and improved cellular uptake of yeast-produced recombinant human lysosomal enzymes

Petra TielsEkaterina BaranovaKathleen PiensCharlotte De VisscherGwenda PynaertWim NerinckxJan StoutFranck FudalejPaco HulpiauSimon Tännler et al.

A1 Journal Article in NATURE BIOTECHNOLOGY

Necrostatin-1 analogues: critical issues on the specificity, activity and in vivo use in experimental disease models

Nozomi TakahashiLinde DuprezSasker GrootjansAnje CauwelsWim NerinckxJB DuHadawayVera GoossensRia RoelandtFilip Van HauwermeirenClaude Libert et al.

A1 Journal Article in CELL DEATH & DISEASE

2010

Synthesis and evaluation of 2-deoxy-2-amino-β-cellobiosides as cellulase inhibitors

Tom DesmetMarc ClaeyssensKathleen PiensWim Nerinckx

A1 Journal Article in JOURNAL OF CARBOHYDRATE CHEMISTRY

2008

An alternative approach for the synthesis of fluorogenic substrates of endo-beta-(1 -> 4)-xylanases and some applications

Maria VrsanskaWim NerinckxMarc ClaeyssensPeter Biely

A1 Journal Article in CARBOHYDRATE RESEARCH

Modulation of activity by Arg407 : structure of a fungal alpha-1,2-mannosidase in complex with a substrate analogue

Yuri LobsanovTakashi YoshidaTom DesmetWim NerinckxPatrick YipMarc ClaeyssensAnnette HerscovicsLynne Howell

A1 Journal Article in ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Theory and computation show that Asp463 is the catalytic proton donor in human endoplasmic reticulum alpha-(1 -> 2)-mannosidase I

David CantuWim NerinckxPeter Reilly

A1 Journal Article in CARBOHYDRATE RESEARCH

2007

An investigation of the substrate specificity of the xyloglucanase Cel74A from Hypocrea jecorina

Tom DesmetTineke CantaertPeter GUALFETTIWim NerinckxLaurie GROSSColin MITCHINSONKathleen Piens

A1 Journal Article in FEBS JOURNAL

The fate of beta-D-mannopyranose after its formation by endoplasmic reticulum alpha-(1 -> 2)-mannosidase I catalysis

Chandrika MulakalaWim NerinckxPeter Reilly

A1 Journal Article in CARBOHYDRATE RESEARCH

2006

Itineraries of enzymatically and non-enzymatically catalyzed substitutions at O-glycopyranosidic bonds

Wim NerinckxTom DesmetMarc Claeyssens

A1 Journal Article in ARKIVOC

Oligosaccharide binding in family 8 glycosidases: Crystal structures of active-site mutants of the beta-1,4-xylanase pXyl from Pseudoaltermonas haloplanktis TAH3a in complex with substrate and product

Dirk De VosT COLLINSWim NerinckxSavvas SavvidesMarc ClaeyssensC GERDAYG FELLERJozef Van Beeumen

A1 Journal Article in BIOCHEMISTRY

2005

An elaboration on the syn-anti proton donor concept of glycoside hydrolases: electrostatic stabilisation of the transition state as a general strategy

Wim NerinckxTom DesmetKathleen PiensMarc Claeyssens

A1 Journal Article in FEBS LETTERS

2004

Evaluation of automated nano-electrospray mass spectrometry in the determination of non-covalent protein-ligand complexes

Kris De VriendtKoen SandraTom DesmetWim NerinckxJozef Van BeeumenBart Devreese

A1 Journal Article in RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Hydrolysis of Nothogenia erinacea xylan by xylanases from families 10 and 11

Wim NerinckxA BROBERGJO DUUSP NTARIMALAS PAROLISH PAROLISMarc Claeyssens

A1 Journal Article in CARBOHYDRATE RESEARCH

On the mechanism of glycoside hydrolysis by the family GH-90 phage P-22 tailspike protein

Wim NerinckxTom DesmetMarc Claeyssens

A2 Journal Article in Internet Electronic Journal of Molecular Design

2003

A cellulose-binding module of the Trichoderma reesei beta-mannanase Man5A increases the. mannan-hydrolysis of complex substrates

P HAGGLUNDT ERIKSSONA COLLENWim NerinckxMarc ClaeyssensH STALBRAND

A1 Journal Article in JOURNAL OF BIOTECHNOLOGY

A hydrophobic platform as a mechanistically relevant transition state stabilising factor appears to be present in the active centre of all glycoside hydrolases

Wim NerinckxTom DesmetMarc Claeyssens

A1 Journal Article in FEBS LETTERS

Biochemical and catalytic properties of an endoxylanase purified from the culture filtrate of Sporotrichum thermophile

P KatapodisM VrsanskaD KekosWim NerinckxP BielyMarc ClaeyssensBJ MacrisP Christakopoulos

A1 Journal Article in CARBOHYDRATE RESEARCH

2002

Biochemical characterization and mode of action of a thermostable endoglucanase purified from Thermoascus aurantiacus.

NJ PARRYDE BEEVERE OWENWim NerinckxMarc ClaeyssensJozef Van BeeumenMK BHAT

A1 Journal Article in ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Novel tools for the study of class I alpha-mannosidases: a chromogenic substrate and a substrate-analog inhibitor.

Tom DesmetWim NerinckxIngeborg StalsNico CallewaertRoland ContrerasMarc Claeyssens

A1 Journal Article in ANALYTICAL BIOCHEMISTRY

2000

Epoxyalkyl glycosides of D-xylose and xylo-oligosaccharides are active-site markers of xylanases from glycoside hydrolase family 11, not from family 10.

P NTARIMAWim NerinckxKlaus KlarskovBart DevreeseMK BHATJozef Van BeeumenMarc Claeyssens

A1 Journal Article in BIOCHEMICAL JOURNAL

Substrate specificity in glycoside hydrolase family 10 - Tyrosine 87 and Leucine 314 play a pivotal, role in discriminating between glucose and xylose binding in the proximal active site of pseudomonas cellulosa xylanase 10A.

SR ANDREWSSJ CHARNOCKJH LAKEYGJ DAVIESMarc ClaeyssensWim NerinckxM UNDERWOOD

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Sudan-β-D-glucuronides and their use for the histochemical localization of β-glucuronidase activity in transgenic plants

Erik Van der EyckenNancy TerrynJL GoemanGunter CarlensWim NerinckxMarc ClaeyssensJohan Van der EyckenMarc Van MontaguM Brito-AriasGilbert Engler

A1 Journal Article in PLANT CELL REPORTS

1999

Crystallographic evidence for substrate ring distortion and protein conformational changes during catalysis in cellobiohydrolase Cel6A from Trichoderma reesei.

JY ZOUGJ KLEYWEGTJ STAHLBERGH DRIGUEZWim NerinckxMarc ClaeyssensA KOIVULATT TEERIITA JONES

A1 Journal Article in STRUCTURE WITH FOLDING & DESIGN

1998

Biochemical and catalytic properties of an endoxylanase purified from the culture filtrate of Thermomyces lanuginosus ATCC 46882.

NA BennettJ RyanP BielyM VrsanskaL KremnickyBJ MacrisD KekosP ChristakopoulosP KatapodisMarc Claeyssens et al.

A1 Journal Article in CARBOHYDRATE RESEARCH

Biochemical characterisation of cellulases and xylanases from Thermoascus aurantiacus

MK BhatNJ ParryS KalogiannisDE BeeverE OwenWim NerinckxMarc Claeyssens

Engineering of the carbohydrate moiety of fungal proteins to a mammalian type

Marleen MarasA De BruynJ SchramlP HerdewijnKathleen PiensMarc ClaeyssensJ UusitaloM PenttilaWalter FiersRoland Contreras

Bookchapter in Carbohydrates from Trichoderma reesei and other microorganisms : structures, biochemistry, genetics and applications

NMR techniques in the study of protein-linked carbohydrates

André De BruynJ SchramlMarleen MarasRoland ContrerasP Herdewijn

1997

The alkaline xylanase III from Fusarium oxysporum F3 belongs to family F/10.

P CHRISTAKOPOULOSWim NerinckxD KEKOSB MACRISMarc Claeyssens

A1 Journal Article in CARBOHYDRATE RESEARCH

1996

Functional characterization of a cellulose binding xylanase from Fusarium oxysporum.

P CHRISTAKOPOULOSWim NerinckxBart SamynD KEKOSB MACRISJozef Van BeeumenMarc Claeyssens

A1 Journal Article in BIOTECHNOLOGY LETTERS

Production and partial characterization of xylanase from Fusarium oxysporum

P ChristakopoulosD MammaWim NerinckxD KekosB MacrisMarc Claeyssens

A1 Journal Article in BIORESOURCE TECHNOLOGY

Purification and mode of action of two low molecular weight alkaline xylanases from Fusarium oxysporum F3

P CHRISTAKOPOULOSWim NerinckxD KEKOSBJ MACRISMarc Claeyssens

A2 Journal Article in Journal Biotechnol. 51

1995

Enantioselectieve alkyleringen, 1,4-addities en Robinson annulaties met ßa-aryl gesubstitueerde carbonylverbindingen bij middel van chirale fase transfer katalysatoren

Purification and characterization of two low molecular mass endo-l,4-ß-D-xylanases from Fusarium oxysporum

P CHRISTAKOPOULOSWim NerinckxKlaus KlarskovJozef Van BeeumenD KEKOSB MACRISMarc Claeyssens

A4 Journal Article in MEDEDELINGEN VAN DE FACULTEIT LANDBOUWKUNDIGE EN TOEGEPASTE BIOLOGISCHE WETENSCHAPPEN, UNIVERSITEIT GENT

1990

Asymmetric alkylation of α-aryl substituted carbonyl compounds by means of chiral phase transfer catalysts : applications for the synthesis of (+)-podocarp-8 (14)-en-13-one and of (-)-wy-16,225, a potent analgestic agent

Wim NerinckxMaurits Vandewalle

A1 Journal Article in TETRAHEDRON-ASYMMETRY

Carbodydrases from Trichoderma reesei and other microorganisms. Structures, Biochemistry, Genetics and Applications. The Royal Society of Chemistry, Cambridge, 1998,351 p.

Marc ClaeyssensWim NerinckxK PIENS