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Researcher
Wim Declercq
Profile
Projects
Publications
Activities
Awards & Distinctions
164
Results
2022
ADAR1 prevents autoinflammation by suppressing spontaneous ZBP1 activation
Richard de Reuver
Simon Verdonck
Evelien Dierick
Josephine Nemegeer
Eline Hessmann
Sadeem Ahmad
Maude Jans
Gillian Blancke
Filip Van Nieuwerburgh
Alexander Botzki
et al.
A1
Journal Article
in
NATURE
2022
Plasma membrane perforation by GSDME during apoptosis-driven secondary necrosis
Elke De Schutter
Jana Ramon
Benjamin Pfeuty
Caroline De Tender
Stephan Stremersch
Koen Raemdonck
Ken Op de Beeck
Wim Declercq
Franck Riquet
Kevin Braeckmans
et al.
A1
Journal Article
in
CELLULAR AND MOLECULAR LIFE SCIENCES
2022
Point mutation I634A in the glucocorticoid receptor causes embryonic lethality by reduced ligand binding
Steven Timmermans
Nicolette J.D. Verhoog
Kelly Van Looveren
Sylviane Dewaele
Tino Hochepied
Melanie Eggermont
Barbara Gilbert
Anne Boerema-de Munck
Tineke Vanderhaeghen
Joke Vanden Berghe
et al.
A1
Journal Article
in
JOURNAL OF BIOLOGICAL CHEMISTRY
2022
2021
Alternaria alternata and Aspergillus fumigatus mold species counteract experimental mycobacterial and allergic lung diseases through divergent innate immune mechanisms
Pauline Lehebel
Olivier Denis
Johan Grooten
Wim Declercq
Dissertation
2021
Characteristic ERK1/2 signaling dynamics distinguishes necroptosis from apoptosis
François Sipieter
Benjamin Cappe
Aymeric Leray
Elke De Schutter
Jolien Bridelance
Paco Hulpiau
Guy Van Camp
Wim Declercq
Laurent Heliot
Pierre Vincent
et al.
A1
Journal Article
in
ISCIENCE
2021
Loss of keratinocyte Mcpip1 abruptly activates the IL-23/Th17 and Stat3 pathways in skin inflammation
Agata Lichawska-Cieslar
Piotr Konieczny
Weronika Szukala
Wim Declercq
Mingui Fu
Jolanta Jura
A1
Journal Article
in
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
2021
2020
Filaggrin expression and processing deficiencies impair corneocyte surface texture and stiffness in mice
Jacob P. Thyssen
Ivone Jakasa
Christoph Riethmüller
Michael P. Schön
Andrea Braun
Marek Haftek
Padraic G. Fallon
Jacek Wróblewski
Hieronim Jakubowski
Leopold Eckhart
et al.
A1
Journal Article
in
JOURNAL OF INVESTIGATIVE DERMATOLOGY
2020
Immunodominant AH1 antigen-deficient necroptotic, but not apoptotic, murine cancer cells induce antitumor protection
Tania Love Aaes
Hanne Verschuere
Agnieszka Kaczmarek
Liesbeth Heyndrickx
Bartosz Wiernicki
Iris Delrue
Bram De Craene
Joachim Taminau
Tinneke Delvaeye
Mathieu Bertrand
et al.
A1
Journal Article
in
JOURNAL OF IMMUNOLOGY
2020
Inhibitors targeting RIPK1/RIPK3 : old and new drugs
Sofie Martens
Sam Hofmans
Wim Declercq
Koen Augustyns
Peter Vandenabeele
A1
Journal Article
in
TRENDS IN PHARMACOLOGICAL SCIENCES
2020
Mouse strain-dependent difference toward the staphylococcus aureus allergen serine protease-like protein D reveals a novel regulator of IL-33
Andrea Renate Teufelberger
Sharon Van Nevel
Paco Hulpiau
Maria Nordengrün
Savvas Savvides
Sarah De Graeve
Srinivas Akula
Gabriële Holtappels
Natalie De Ruyck
Wim Declercq
et al.
A1
Journal Article
in
FRONTIERS IN IMMUNOLOGY
2020
Sensing of endogenous nucleic acids by ZBP1 induces keratinocyte necroptosis and skin inflammation
Michael Devos
Giel Tanghe
Barbara Gilbert
Evelien Dierick
Maud Verheirstraeten
Josephine Nemegeer
Richard de Reuver
Sylvie Lefebvre
Jolien De Munck
Jan Rehwinkel
et al.
A1
Journal Article
in
JOURNAL OF EXPERIMENTAL MEDICINE
2020
2019
A20 protects cells from TNF-induced apoptosis through linear ubiquitin-dependent and -independent mechanisms
Dario Priem
Michael Devos
Sarah Druwé
Arne Martens
Karolina Slowicka
Adrian T Ting
Manolis Pasparakis
Wim Declercq
Peter Vandenabeele
Geert van Loo
et al.
A1
Journal Article
in
CELL DEATH & DISEASE
2019
Blocking connexin43 hemichannels protects mice against tumour necrosis factor-induced inflammatory shock
Tinneke Delvaeye
Maarten De Smet
Stijn Verwaerde
Elke Decrock
Aleksandra Czekaj
Roosmarijn Vandenbroucke
Kelly Lemeire
Amanda Gonçalves
Wim Declercq
Peter Vandenabeele
et al.
A1
Journal Article
in
SCIENTIFIC REPORTS
2019
Delivery of mixed-lineage kinase domain-like protein by vapor nanobubble photoporation induces necroptotic-like cell death in tumor cells
Lien Van Hoecke
Laurens Raes
Stephan Stremersch
Toon Brans
Juan Fraire
Ria Roelandt
Wim Declercq
Peter Vandenabeele
Koen Raemdonck
Kevin Braeckmans
et al.
A1
Journal Article
in
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
2019
Epithelial HMGB1 delays skin wound healing and drives tumor initiation by priming neutrophils for NET formation
Esther Hoste
Christian Maueröder
Lisette Van Hove
Leen Catrysse
Hanna-Kaisa Vikkula
Mozes Sze
Bastiaan Maes
Dyah Karjosukarso
Liesbet Martens
Amanda Gonçalves
et al.
A1
Journal Article
in
CELL REPORTS
2019
Keratinocyte expression of A20/TNFAIP3 controls skin inflammation associated with atopic dermatitis and psoriasis
Michael Devos
Denis A Mogilenko
Sébastien Fleury
Barbara Gilbert
Coralie Becquart
Sandrine Quemener
Hélène Dehondt
Peter Tougaard
Bart Staels
Claus Bachert
et al.
A1
Journal Article
in
JOURNAL OF INVESTIGATIVE DERMATOLOGY
2019
Keratinocyte-specific ablation of Mcpip1 impairs skin integrity and promotes local and systemic inflammation
Piotr Konieczny
Agata Lichawska-Cieslar
Patrycja Kwiecinska
Joanna Cichy
Roza Pietrzycka
Weronika Szukala
Wim Declercq
Michael Devos
Agnieszka Paziewska
Izabela Rumienczyk
et al.
A1
Journal Article
in
JOURNAL OF MOLECULAR MEDICINE-JMM
2019
Synthesis and evaluation of novel benzotropolones as Atg4B inhibiting autophagy blockers
Muhammet Tanc
Matthias Cleenewerck
Ammar Kurdi
Ria Roelandt
Wim Declercq
Guido De Meyer
Koen Augustyns
Wim Martinet
Pieter Van der Veken
A1
Journal Article
in
BIOORGANIC CHEMISTRY
2019
Walter Fiers (1931-2019) : obituary
Wim Declercq
Peter Vandenabeele
Xavier Saelens
Biography
2019
2018
Keratinocyte-Specific Ablation of RIPK4 Allows Epidermal Cornification but Impairs Skin Barrier Formation
Corinne Urwyler
Giel Tanghe
Kirsten Leurs
Barbara Gilbert
Riet De Rycke
Michiel De Bruyne
Saskia Lippens
Sona Bartunkova
Philippe De Groote
Carien Niessen
et al.
A1
Journal Article
in
JOURNAL OF INVESTIGATIVE DERMATOLOGY
2018
MLKL reveals its friendly face : a role in nerve regeneration
Peter Vandenabeele
Wim Declercq
Ria Roelandt
Tom Vanden Berghe
Editorial material
2018
Mechanistic insights into the regulation of RIPK4 and its function in skin homeostasis and pathology
Giel Tanghe
Wim Declercq
Dissertation
2018
RIPK4 activity in keratinocytes is controlled by the SCFβ-TrCP ubiquitin ligase to maintain cortical actin organization
Giel Tanghe
Corinne Urwyler
Philippe De Groote
Emmanuel Dejardin
Pieter-Jan De Bock
Kris Gevaert
Peter Vandenabeele
Wim Declercq
A1
Journal Article
in
CELLULAR AND MOLECULAR LIFE SCIENCES
2018
The IL-33/ST2 axis is crucial in type 2 airway responses induced by Staphylococcus aureus-derived serine protease-like protein D
Andrea Renate Teufelberger
Maria Nordengrün
Harald Braun
Tania Maes
Katrien De Grove
Gabriële Holtappels
Clara O'Brien
Sharen Provoost
Hamida Hammad
Amanda Gonçalves
et al.
A1
Journal Article
in
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
2018
2017
ATG4B inhibitors with a benzotropolone core structure block autophagy and augment efficiency of chemotherapy in mice
Ammar Kurdi
Matthias Cleenewerck
Christel Vangestel
Sophie Lyssens
Wim Declercq
Jean-Pierre Timmermans
Sigrid Stroobants
Koen Augustyns
Guido RY De Meyer
Pieter Van Der Veken
et al.
A1
Journal Article
in
BIOCHEMICAL PHARMACOLOGY
2017
Cell-type-specific chromatin states differentially prime squamous cell carcinoma tumor-initiating cells for epithelial to mesenchymal transition
Mathilde Latil
Dany Nassar
Benjamin Beck
Soufiane Boumahdi
Li Wang
Audrey Brisebarre
Christine Dubois
Erwin Nkusi
Sandrine Lenglez
Agnieszka Checinska
et al.
A1
Journal Article
in
CELL STEM CELL
2017
Elevated ΔNp63α levels facilitate epidermal and biliary oncogenic transformation
Michael Devos
Barbara Gilbert
Geertrui Denecker
Kirsten Leurs
Conor Mc Guire
Kelly Lemeire
Tino Hochepied
Marnik Vuylsteke
Jo Lambert
Caroline Van den Broecke
et al.
A1
Journal Article
in
JOURNAL OF INVESTIGATIVE DERMATOLOGY
2017
Feasibility study for clinical application of caspase-3 inhibitors in Pemphigus vulgaris
William VJ Hariton
Arnaud Galichet
Tom Vanden Berghe
Andrew M Overmiller
My G Mahoney
Wim Declercq
Eliane J Müller
A1
Journal Article
in
EXPERIMENTAL DERMATOLOGY
2017
Study of the functions of RIPK4 in epidermal development and signal transduction
Corinne Urwyler
Wim Declercq
Peter Vandenabeele
Dissertation
2017
Varkens kweken waarop de Romeinen verzot waren
Edith Van Wuytswinkel
Ruben Brabant
Benedikt Sas
Wim Declercq
Hendrik Dierendonck
Newsarticle
2017
2016
Generation of a new Gateway-compatible inducible lentiviral vector platform allowing easy derivation of co-transduced cells
Philippe De Groote
Sasker Grootjans
Saskia Lippens
Chantal Eichperger
Kirsten Leurs
Irene Kahr
Giel Tanghe
Inge Bruggeman
Wouter De Schamphelaire
Corinne Urwyler
et al.
A1
Journal Article
in
BIOTECHNIQUES
2016
Inhibitor screening and enzymatic activity determination for autophagy target Atg4B using a gel electrophoresis-based assay
Matthias Cleenewerck
Mandy OJ Grootaert
Rafaela Gladysz
Yves Adriaenssens
Ria Roelandt
Jurgen Joossens
Anne-Marie Lambeir
Guido RY De Meyer
Wim Declercq
Koen Augustyns
et al.
A1
Journal Article
in
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
2016
Martin Leverkus, MD (1965-2016) : in memoriam
Diana Panayotova-Dimitrova
Wim Declercq
Biography
2016
Vaccination with necroptotic cancer cells induces efficient anti-tumor immunity
Tania Love Aaes
Agnieszka Kaczmarek
Tinneke Delvaeye
Bram De Craene
Stefaan De Koker
Liesbeth Heyndrickx
Iris Delrue
Joachim Taminau
Bartosz Wiernicki
Philippe De Groote
et al.
A1
Journal Article
in
CELL REPORTS
2016
2015
A novel RIPK4-IRF6 connection is required to prevent epithelial fusions characteristic for popliteal pterygium syndromes
Philippe De Groote
Hong Tran Thi
Mathias Fransen
Giel Tanghe
Corinne Urwyler
Bram De Craene
Kirsten Leurs
Barbara Gilbert
Griet Van Imschoot
Riet De Rycke
et al.
A1
Journal Article
in
CELL DEATH AND DIFFERENTIATION
2015
Interaction of Mycobacterium leprae with the HaCaT human keratinocyte cell line: new frontiers in the cellular immunology of leprosy
Eloah CD Lyrio
Ivy C Campos-Souza
Luiz CD Corrêa
Guilherme C Lechuga
Mauricio Verícimo
Helena C Castro
Saulo C Bourguignon
Suzana Côrte-Real
Norman Ratcliffe
Wim Declercq
et al.
A1
Journal Article
in
EXPERIMENTAL DERMATOLOGY
2015
2014
Deregulation of the replisome factor MCMBP prompts oncogenesis in colorectal carcinomas through chromosomal instability
Mauricio Quimbaya Gomez
Eric Raspé
Geertrui Denecker
Bram De Craene
Ria Roelandt
Wim Declercq
Xavier Sagaert
Lieven De Veylder
Geert Berx
A1
Journal Article
in
NEOPLASIA
2014
MLKL compromises plasma membrane integrity by binding to phosphatidylinositol phosphates
Yves Dondelinger
Wim Declercq
Sylvie Montessuit
Ria Roelandt
Amanda Gonçalves
Inge Bruggeman
Paco Hulpiau
Kathrin Weber
Clark A Sehon
Robert W Marquis
et al.
A1
Journal Article
in
CELL REPORTS
2014
RIPK1 ensures intestinal homeostasis by protecting the epithelium against apoptosis
Nozomi Takahashi
Lars Vereecke
Mathieu Bertrand
Linde Duprez
Scott B Berger
Tatyana Divert
Amanda Gonçalves
Mozes Sze
Barbara Gilbert
Stephanie Kourula
et al.
A1
Journal Article
in
NATURE
2014
Simultaneous targeting of IL-1 and IL-18 is required for protection against inflammatory and septic shock
Tom Vanden Berghe
Dieter Demon
Pieter Bogaert
Benjamin Vandendriessche
Alain Goethals
Bart Depuydt
Marnik Vuylsteke
Ria Roelandt
Elien Van Wonterghem
Jill Vandenbroecke
et al.
A1
Journal Article
in
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
2014
The skin microbiome of caspase-14-deficient mice shows mild dysbiosis
Malgorzata Kubica
Falk Hildebrand
Brigitta Brinkman
Dirk Goossens
Jurgen Del Favero
Ken Vercammen
Pierre Cornelis
Jens-Michael Schröder
Peter Vandenabeele
Jeroen Raes
et al.
A1
Journal Article
in
EXPERIMENTAL DERMATOLOGY
2014
2013
CDK4 T172 phosphorylation is central in a CDK7-dependent bidirectional CDK4/CDK2 interplay mediated by p21 phosphorylation at the restriction point
Xavier Bisteau
Sabine Paternot
Bianca Colleoni
Karin Ecker
Katia Coulonval
Philippe De Groote
Wim Declercq
Ludger Hengst
Pierre P Roger
A1
Journal Article
in
PLOS GENETICS
2013
Caspase-14
Wim Declercq
Bookchapter
in
Handbook of proteolytic enzymes
2013
Caspase-14 overexpression in hairless mice is not involved in utricle formation
Michael Devos
Philippe De Groote
Barbara Gilbert
Inge Bruggeman
Kirsten Leurs
Saskia Lippens
Peter Vandenabeele
Wim Declercq
A1
Journal Article
in
EXPERIMENTAL DERMATOLOGY
2013
Caspase-14-deficient mice are more prone to the development of parakeratosis
Esther Hoste
Geertrui Denecker
Barbara Gilbert
Filip Van Nieuwerburgh
Leslie van der Fits
Bob Asselbergh
Riet De Rycke
Jean-Pierre Hachem
Dieter Deforce
Errol P Prens
et al.
A1
Journal Article
in
JOURNAL OF INVESTIGATIVE DERMATOLOGY
2013
Cell death by cornification
Leopold Eckhart
Saskia Lippens
Erwin Tschachler
Wim Declercq
A1
Journal Article
in
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
2013
Compound A, a selective glucocorticoid receptor modulator, enhances heat shock protein Hsp70 gene promoter activation
Ilse Beck
Zuzanna Drebert
Ruben Hoya-Arias
Ali A Bahar
Michael Devos
Dorien Clarisse
Sofie Desmet
Nadia Bougarne
Bart Ruttens
Valerie Gossye
et al.
A1
Journal Article
in
PLOS ONE
2013
2012
Filaggrin degradation by caspase-14 is required for UVB photoprotection but does not influence allergic sensitization in a mouse model of atopic dermatitis
Michael Devos
Janne Prawitt
Delphine Staumont-Salle
Esther Hoste
Sebastién Fleury
Emmanuel Bouchaert
Barbara Gilbert
Saskia Lippens
Peter Vandenabeele
David Dombrowicz
et al.
A1
Journal Article
in
JOURNAL OF INVESTIGATIVE DERMATOLOGY
2012
Necrostatin-1 analogues: critical issues on the specificity, activity and in vivo use in experimental disease models
Nozomi Takahashi
Linde Duprez
Sasker Grootjans
Anje Cauwels
Wim Nerinckx
JB DuHadaway
Vera Goossens
Ria Roelandt
Filip Van Hauwermeiren
Claude Libert
et al.
A1
Journal Article
in
CELL DEATH & DISEASE
2012
Study of RIPK4 function in skin homeostasis and disease
Philippe De Groote
Wim Declercq
Saskia Lippens
Peter Vandenabeele
Dissertation
2012
Study on the role of ΔNp63α and caspase-14 in skin homeostasis and pathology
Michael Devos
Wim Declercq
Peter Vandenabeele
Dissertation
2012
2011
18th Euroconference on Apoptosis in Ghent, Belgium, 1-4 September 2010
Wim Declercq
P Agostinis
Peter Vandenabeele
Editorial material
2011
Caspase deficiency alters the murine gut microbiome
Brigitta Brinkman
F Hildebrand
Malgorzata Kubica
D Goosens
J Del Favero
Wim Declercq
J Raes
Peter Vandenabeele
A1
Journal Article
in
CELL DEATH & DISEASE
2011
Caspase-14 is required for filaggrin degradation to natural moisturizing factors in the skin
Esther Hoste
Patrick Kemperman
Michael Devos
Geertrui Denecker
Sanja Kezic
Nico Yau
Barbara Gilbert
Saskia Lippens
Philippe De Groote
Ria Roelandt
et al.
A1
Journal Article
in
JOURNAL OF INVESTIGATIVE DERMATOLOGY
2011
Cell death in the skin
Saskia Lippens
Esther Hoste
Peter Vandenabeele
Wim Declercq
Bookchapter
in
Apoptosis : physiology and pathology
2011
Dual face apoptotic machinery: from initiator of apoptosis to guardian of necroptosis
Wim Declercq
Nozomi Takahashi
Peter Vandenabeele
Editorial material
2011
Inhibition of kallikrein-related peptidases by the serine protease inhibitor of Kazal-type 6
Tomasz Kantyka
Jan Fischer
Zhihong Wu
Wim Declercq
Karina Reiss
Jens-Michael Schröder
Ulf Meyer-Hoffert
A1
Journal Article
in
PEPTIDES
2011
Keratinocyte-specific ablation of the NF-κB regulatory protein A20 (TNFAIP3) reveals a role in the control of epidermal homeostasis
Saskia Lippens
S Lefebvre
Barbara Gilbert
Mozes Sze
Michael Devos
Kelly Verhelst
Lars Vereecke
Conor Mc Guire
Chris Guerin
Peter Vandenabeele
et al.
A1
Journal Article
in
CELL DEATH AND DIFFERENTIATION
2011
RIP Kinase-dependent necrosis drives lethal systemic inflammatory response syndrome
Linde Duprez
Nozomi Takahashi
Filip Van Hauwermeiren
Benjamin Vandendriessche
Vera Goossens
Tom Vanden Berghe
Wim Declercq
Claude Libert
Anje Cauwels
Peter Vandenabeele
A1
Journal Article
in
IMMUNITY
2011
cIAP1/2 are direct E3 ligases conjugating diverse types of ubiquitin chains to receptor interacting proteins kinases 1 to 4 (RIP1-4)
Mathieu Bertrand
Saskia Lippens
An Staes
Barbara Gilbert
Ria Roelandt
Jelle De Medts
Kris Gevaert
Wim Declercq
Peter Vandenabeele
A1
Journal Article
in
PLOS ONE
2011
p63, a story of mice and men
Hans Vanbokhoven
Gerry Melino
Eleonora Candi
Wim Declercq
A1
Journal Article
in
JOURNAL OF INVESTIGATIVE DERMATOLOGY
2011
2010
Caspase-mediated cleavage of Beclin-1 inactivates Beclin-1-induced autophagy and enhances apoptosis by promoting the release of proapoptotic factors from mitochondria
Ellen Wirawan
Lieselotte Vande Walle
Kristof Kersse
Sigrid Cornelis
S Claerhout
Isabel Vanoverberghe
Ria Roelandt
Riet De Rycke
Jelle Verspurten
Wim Declercq
et al.
A1
Journal Article
in
CELL DEATH & DISEASE
2010
Caspases in epidermal differentiation and cornification
Wim Declercq
Editorial material
2010
Necroptosis, necrosis and secondary necrosis converge on similar cellular disintegration features
Tom Vanden Berghe
Nele Vanlangenakker
Eef Parthoens
Wies Deckers
Michael Devos
Nele Festjens
Chris Guerin
UT Brunk
Wim Declercq
Peter Vandenabeele
A1
Journal Article
in
CELL DEATH AND DIFFERENTIATION
2010
Study of the role of caspase-14 in epidermal cornification
Esther Hoste
Wim Declercq
Peter Vandenabeele
Dissertation
2010
The role of the kinases RIP1 and RIP3 in TNF-induced necrosis
Peter Vandenabeele
Wim Declercq
Franky Van Herreweghe
Tom Vanden Berghe
A1
Journal Article
in
SCIENCE SIGNALING
2010
Tumor necrosis factor-mediated cell death: to break or to burst, that's the question
Franky Van Herreweghe
Nele Festjens
Wim Declercq
Peter Vandenabeele
A1
Journal Article
in
CELLULAR AND MOLECULAR LIFE SCIENCES
2010
2009
Caspase substrates: easily caught in deep waters?
Dieter Demon
Petra Van Damme
Tom Vanden Berghe
Joël Vandekerckhove
Wim Declercq
Kris Gevaert
Peter Vandenabeele
A1
Journal Article
in
TRENDS IN BIOTECHNOLOGY
2009
Cell death in the skin
Saskia Lippens
Esther Hoste
Peter Vandenabeele
Patrizia Agostinis
Wim Declercq
A1
Journal Article
in
APOPTOSIS
2009
Death receptor-induced necroptosis
Wim Declercq
Franky Van Herreweghe
Tom Vanden Berghe
Peter Vandenabeele
Bookchapter
in
Encyclopedia of life sciences
2009
Function of caspase-14 in trophoblast differentiation
LJ White
Wim Declercq
F Arfuso
AK Charles
AM Dharmarajan
A1
Journal Article
in
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
2009
Proteome-wide substrate analysis indicates substrate exclusion as a mechanism to generate caspase-7 versus caspase-3 specificity
Dieter Demon
Petra Van Damme
Tom Vanden Berghe
Annelies Deceuninck
Joost Van Durme
Jelle Verspurten
Kenny Helsens
Francis Impens
Magdalena Wejda
Joost Schymkowitz
et al.
A1
Journal Article
in
MOLECULAR & CELLULAR PROTEOMICS
2009
RIP Kinases at the Crossroads of Cell Death and Survival
Wim Declercq
Tom Vanden Berghe
Peter Vandenabeele
A1
Journal Article
in
CELL
2009
SitePredicting the cleavage of proteinase substrates
Jelle Verspurten
Kris Gevaert
Wim Declercq
Peter Vandenabeele
A1
Journal Article
in
TRENDS IN BIOCHEMICAL SCIENCES
2009
The "Caveolae Brake Hypothesis" and the Epidermal Barrier
Truus Roelandt
Christina Giddelo
Carol Heughebaert
Geertrui Denecker
Melanie Hupe
Debra Crumrine
Andy Kusuma
Marek Haftek
Diane Rosseeuw
Wim Declercq
et al.
A1
Journal Article
in
JOURNAL OF INVESTIGATIVE DERMATOLOGY
2009
The emerging roles of serine protease cascades in the epidermis
Petra Ovaere
Saskia Lippens
Peter Vandenabeele
Wim Declercq
A1
Journal Article
in
TRENDS IN BIOCHEMICAL SCIENCES
2009
2008
Acute modulations in permeability barrier function regulate epidermal cornification - Role of caspase-14 and the protease activated receptor type 2
M DEMERJIAN
JP HACHEM
E TSCHACHLER
Geertrui Denecker
Wim Declercq
Peter Vandenabeele
T MAURO
M HUPE
D CRUMRINE
T ROELANDT
et al.
A1
Journal Article
in
AMERICAN JOURNAL OF PATHOLOGY
2008
Apoptosome and caspase activation
Wim Declercq
Peter Vandenabeele
Bookchapter
in
Wiley Encyclopedia of Chemical Biology
2008
Caspase-14 reveals its secrets
Geertrui Denecker
Petra Ovaere
Peter Vandenabeele
Wim Declercq
A1
Journal Article
in
JOURNAL OF CELL BIOLOGY
2008
Caspases
Kristof Kersse
Wim Declercq
Peter Vandenabeele
Bookchapter
in
Encyclopedia of molecular pharmacology
2008
Necrotic cell death and 'necrostatins': now we can control cellular explosion
Peter Vandenabeele
Wim Declercq
Tom Vanden Berghe
A1
Journal Article
in
TRENDS IN BIOCHEMICAL SCIENCES
2008
Role of Caspases in inflammation-driven diseases
Kristof Kersse
Tom Vanden Berghe
Saskia Lippens
Wim Declercq
Peter Vandenabeele
Bookchapter
in
Design of Caspase inhibitors as potential clinical agents
2008
2007
Are metacaspases caspases?
Dominique Vercammen
Wim Declercq
Peter Vandenabeele
Frank Van Breusegem
A1
Journal Article
in
JOURNAL OF CELL BIOLOGY
2007
Caspase-14 protects against epidermal UVB photo-damage and water loss
Geertrui Denecker
Esther Hoste
Barbara Gilbert
Tino Hochepied
Petra Ovaere
Saskia Lippens
C VAN DEN BROUCKE
Petra Van Damme
Katharina D'Herde
J HACHEM
et al.
C3
Conference
2007
Caspase-14 protects against epidermal UVB photo-damage and water loss.
Geertrui Denecker
Esther Hoste
Barbara Gilbert
Tino Hochepied
Petra Ovaere
Saskia Lippens
C VAN DEN BROUCKE
Petra Van Damme
Katharina D'Herde
J HACHEM
et al.
C3
Conference
2007
Caspase-14 protects against epidermal UVB photodamage and water loss
Geertrui Denecker
Esther Hoste
Barbara Gilbert
Tino Hochepied
Petra Ovaere
Saskia Lippens
Caroline Van den broecke
Petra Van Damme
Katharina D'Herde
JP HACHEM
et al.
A1
Journal Article
in
NATURE CELL BIOLOGY
2007
Caspases in cell survival, proliferation and differentiation
Mohamed Lamkanfi
Nele Festjens
Wim Declercq
Tom Vanden Berghe
Peter Vandenabeele
A1
Journal Article
in
CELL DEATH AND DIFFERENTIATION
2007
Generation of active recombinant human caspase-14
Philippe De Groote
Petra Ovaere
Esther Hoste
Geertrui Denecker
Saskia Lippens
Peter Vandenabeele
Wim Declercq
C3
Conference
2007
Identification and characterization of filaggrin as a caspase-14 substrate
Esther Hoste
Geertrui Denecker
Petra Van Damme
RB PRESLAND
Joël Vandekerckhove
Kris Gevaert
Peter Vandenabeele
Wim Declercq
C3
Conference
2007
NADPH oxidases: new players in TNIF-induced necrotic cell death
Tom Vanden Berghe
Wim Declercq
Peter Vandenabeele
Editorial material
2007
Permeability barrier requirements regulate keratinocyte cornification: role of caspase 14 and the protease-activated receptor type 2
M DEMERJIAN
J HACHEM
E TSCHACHLER
Geertrui Denecker
Wim Declercq
Peter Vandenabeele
TM MAURO
D CRUMRINE
T ROELANDT
E HOUBEN
et al.
C3
Conference
2007
2006
Caspases leave the beaten track: caspase-mediated activation of NF-kappa B
Mohamed Lamkanfi
Wim Declercq
Tom Vanden Berghe
Peter Vandenabeele
A1
Journal Article
in
JOURNAL OF CELL BIOLOGY
2006
Role of caspase-14 in terminal differentiation of keratinocytes
Geertrui Denecker
Esther Hoste
Barbara Gilbert
Tino Hochepied
Petra Ovaere
Saskia Lippens
Caroline Vandenbroucke
Katharina D'Herde
Peter Vandenabeele
Wim Declercq
C3
Conference
2006
The secret life of caspase-14
Geertrui Denecker
Esther Hoste
T HOCHPIED
Barbara Gilbert
Petra Ovaere
Katharina D'Herde
Caroline Vandenbroucke
Saskia Lippens
Lore Schoonjans
Claude Libert
et al.
C3
Conference
2006
2005
A novel caspase-2 complex containing TRAF2 and RIP1
Mohamed Lamkanfi
Kathleen D'Hondt
Lieselotte Vande Walle
Marjan Van Gurp
Geertrui Denecker
Jill Demeulemeester
Michaël Kalai
Wim Declercq
Xavier Saelens
Peter Vandenabeele
A1
Journal Article
in
JOURNAL OF BIOLOGICAL CHEMISTRY
2005
Caspase-14 but not caspase-3 is processed during the development of fetal mouse epidermis
H FISCHER
H ROSSITER
M GHANNADAN
K JAEGER
C BARRESI
Wim Declercq
E TSCHACHLER
L ECKHART
A1
Journal Article
in
DIFFERENTIATION
2005
Death penalty for keratinocytes: apoptosis versus cornification
Saskia Lippens
Geertrui Denecker
Petra Ovaere
Peter Vandenabeele
Wim Declercq
A1
Journal Article
in
CELL DEATH AND DIFFERENTIATION
2005
Induction of apoptosis by TNF receptor 2 in a T-cell hybridoma is FADD dependent and blocked by caspase-8 inhibitors
Bart Depuydt
Geert van Loo
Peter Vandenabeele
Wim Declercq
A1
Journal Article
in
JOURNAL OF CELL SCIENCE
2005
Requirement for tumor necrosis factor-receptor 2 in alveolar chemokine expression depends upon the form of the ligand
J Liu
MQ Zhao
LM Xu
CV Ramana
Wim Declercq
Peter Vandenabeele
RI Enelow
A1
Journal Article
in
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
2005
2004
Activation of p38 MAPK is required for Bax translocation to mitochondria, cytochrome c release and apoptosis induced by UVB irradiation in human keratinocytes
A VAN LAETHEM
S VAN KELST
Saskia Lippens
Wim Declercq
Peter Vandenabeele
S JANSSENS
JR VANDENHEEDE
M GARMYN
P AGOSTINIS
A1
Journal Article
in
FASEB JOURNAL
2004
Caspase-1 activates nuclear factor of the kappa-enhancer in B cells independently of its enzymatic activity
Mohamed Lamkanfi
Michaël Kalai
Xavier Saelens
Wim Declercq
Peter Vandenabeele
A1
Journal Article
in
JOURNAL OF BIOLOGICAL CHEMISTRY
2004
Cleavage of caspase-14 coincides with stratum corneum formation during development of fetal mouse skin
H FISCHER
L ECKHART
C BARESI
M GHANNADAN
H ROSSITER
M BUCHBERGER
Saskia Lippens
Wim Declercq
E TSCHACHLER
C3
Conference
2004
Differential signaling to apoptotic and necrotic cell death by Fas-associated death domain protein FADD
Tom Vanden Berghe
Geert van Loo
Xavier Saelens
Marjan Van Gurp
Greet Brouckaert
Michaël Kalai
Wim Declercq
Peter Vandenabeele
A1
Journal Article
in
JOURNAL OF BIOLOGICAL CHEMISTRY
2004
INCA, a novel human caspase recruitment domain protein that inhibits interleukin-1 beta generation
Mohamed Lamkanfi
Geertrui Denecker
Michaël Kalai
Kathleen D'Hondt
Ann Meeus
Wim Declercq
Xavier Saelens
Peter Vandenabeele
A1
Journal Article
in
JOURNAL OF BIOLOGICAL CHEMISTRY
2004
Stratum corneum-derived caspase-14 is catalytically active
H FISCHER
M STICHENWIRTH
M DOCKAL
M GHANNADAN
M BUCHBERGER
J BACH
A KAPETANOPOULOS
Wim Declercq
E TSCHACHLER
L ECKHART
A1
Journal Article
in
FEBS LETTERS
2004
Vitamin D3 induces caspase-14 expression in psoriatic lesions and enhances caspase-14 processing in organotypic skin cultures
Saskia Lippens
M KOCKX
Geertrui Denecker
M KNAAPEN
A VERHEYEN
R CHRISTIAEN
E TSCHACHLER
Peter Vandenabeele
Wim Declercq
A1
Journal Article
in
AMERICAN JOURNAL OF PATHOLOGY
2004
2003
A Bcl-2 transgene expressed in hepatocytes does not protect mice from fulminant liver destruction induced by Fas ligand
Geert van Loo
Saskia Lippens
M HAHNE
Filip Matthijssens
Wim Declercq
Xavier Saelens
Peter Vandenabeele
A1
Journal Article
in
CYTOKINE
2003
Caspase-14 is expressed in the epidermis, the choroid plexus, the retinal pigment epithelium and thymic Hassall's bodies
Saskia Lippens
Caroline Van den Broecke
Elke Van Damme
E Tschachler
Peter Vandenabeele
Wim Declercq
A1
Journal Article
in
CELL DEATH AND DIFFERENTIATION
2003
Disruption of HSP90 function reverts tumor necrosis factor-induced necrosis to apoptosis
Tom Vanden Berghe
Michaël Kalai
Geert van Loo
Wim Declercq
Peter Vandenabeele
A1
Journal Article
in
JOURNAL OF BIOLOGICAL CHEMISTRY
2003
Regulation of the expression and processing of caspase-12
Michaël Kalai
Mohamed Lamkanfi
Geertrui Denecker
M Boogmans
Saskia Lippens
Ann Meeus
Wim Declercq
Peter Vandenabeele
A1
Journal Article
in
JOURNAL OF CELL BIOLOGY
2003
The caspase family
Mohamed Lamkanfi
Wim Declercq
Bart Depuydt
Michaël Kalai
Xavier Saelens
Peter Vandenabeele
Bookchapter
in
Caspases-Their Role in Cell Death and Cell Survival
2003
Ultraviolet B radiation-induced apoptosis in human keratinocytes: cytosolic activation of procaspase-8 and the role of Bcl-2
Z ASSEFA
M GARMYN
A VANTIEGHEM
Wim Declercq
Peter Vandenabeele
JR VANDENHEEDE
P AGOSTINIS
A1
Journal Article
in
FEBS LETTERS
2003
2002
A matrix-assisted laser desorption ionization post-source decay (MALDI-PSD) analysis of proteins released from isolated liver mitochondria treated with recombinant truncated Bid
Geert van Loo
Hans Demol
Marjan Van Gurp
B Hoorelbeke
Peter Schotte
Rudi Beyaert
B Zhivotovsky
Kris Gevaert
Wim Declercq
Joël Vandekerckhove
et al.
A1
Journal Article
in
CELL DEATH AND DIFFERENTIATION
2002
Alice in caspase land. A phylogenetic analysis of caspases from worm to man.
Mohamed Lamkanfi
Wim Declercq
Michaël Kalai
Xavier Saelens
Peter Vandenabeele
Editorial material
2002
Caspases are not localized in mitochondria during life or death
Geert van Loo
Xavier Saelens
Filip Matthijssens
Peter Schotte
Rudi Beyaert
Wim Declercq
Peter Vandenabeele
A1
Journal Article
in
CELL DEATH AND DIFFERENTIATION
2002
The serine protease Omi/HtrA2 is released from mitochondria during apoptosis. Omi interacts with caspase-inhibitor XIAP and induces enhanced caspase activity.
Geert van Loo
Marjan Van Gurp
Bart Depuydt
SM SRINIVASULA
I RODRIGUEZ
ES ALNEMRI
Kris Gevaert
Joël Vandekerckhove
Wim Declercq
Peter Vandenabeele
A1
Journal Article
in
CELL DEATH AND DIFFERENTIATION
2002
2001
Apoptotic and necrotic cell death induced by death domain receptors.
Geertrui Denecker
D VERCAMMEN
Wim Declercq
Peter Vandenabeele
A1
Journal Article
in
CELLULAR AND MOLECULAR LIFE SCIENCES
2001
Death receptor-induced apoptotic and necrotic cell death: differential role of caspases and mitochondria.
Geertrui Denecker
D VERCAMMEN
Margino Steemans
Tom Vanden Berghe
Greet Brouckaert
Geert van Loo
B ZHIVOTOVSKY
Walther Fiers
Johan Grooten
Wim Declercq
et al.
A1
Journal Article
in
CELL DEATH AND DIFFERENTIATION
2001
Endonuclease G: a mitochondrial protein released in apoptosis and involved in caspaseindependent DNA degradation
Geert van Loo
Peter Schotte
Marjan Van Gurp
Hans Demol
B HOORELBEKE
Kris Gevaert
I RODRIGUEZ
A RUIZ-CARRILLO
Joël Vandekerckhove
Wim Declercq
et al.
A1
Journal Article
in
CELL DEATH AND DIFFERENTIATION
2001
Heterotrimers formed by tumor necrosis factors of different species or muteins.
Paul Ameloot
Wim Declercq
Walther Fiers
Peter Vandenabeele
Peter Brouckaert
A1
Journal Article
in
JOURNAL OF BIOLOGICAL CHEMISTRY
2001
Mouse mammary gland involution is associated with cytochrome c release and caspase activation.
A MARTI
PM RITTER
R JAGER
H LAZAR
A BALTZER
J SCHENKEL
Wim Declercq
Peter Vandenabeele
R JAGGI
A1
Journal Article
in
MECHANISMS OF DEVELOPMENT
2001
The somatostatin analogue TT-232 induces apoptosis in A431 cells - Sustained activation of stress-activated kinases and inhibition of signalling to extracellular signal-regulated kinases.
T VANTUS
G KERI
Z KRIVICKIENE
M VALIUS
A STETAK
S KEPPENS
P CSERMELY
PI BAUER
G BOKONYI
Wim Declercq
et al.
A1
Journal Article
in
CELLULAR SIGNALLING
2001
Yersinia enterocolitica YopP-induced apoptosis of macrophages involves the apoptotic signaling cascade upstream of Bid.
Geertrui Denecker
Wim Declercq
C GEUIJEN
A BOLAND
R BENABDILLAH
Marjan Van Gurp
MP SORY
Peter Vandenabeele
GR CORNELIS
A1
Journal Article
in
JOURNAL OF BIOLOGICAL CHEMISTRY
2001
2000
A role for potassium in TNF-induced apoptosis and gene-induction in human and rodent tumour cell lines.
LC PENNING
Geertrui Denecker
D VERCAMMEN
Wim Declercq
RG SCHIPPER
Peter Vandenabeele
A1
Journal Article
in
CYTOKINE
2000
Cloning and expression of cytokine genes
Wim Declercq
Marc Logghe
Walther Fiers
Roland Contreras
Bookchapter
in
Cytokine molecular biology : a practical approach
2000
Epidermal differentiation does not involve the pro-apoptotic executioner caspases, but is associated with caspase-14 induction and processing.
Saskia Lippens
M KOCKX
M KNAAPEN
L MORTIER
R POLAKOWSKA
A VERHEYEN
M GARMYN
A ZWIJSEN
P FORMSTECHER
D HUYLEBROECK
et al.
A1
Journal Article
in
CELL DEATH AND DIFFERENTIATION
2000
Phosphatidyl serine exposure during apoptosis precedes release of cytochrome c and decrease in mitochondrial transmembrane potential.
Geertrui Denecker
Hans Dooms
Geert van Loo
D VERCAMMEN
Johan Grooten
Walther Fiers
Wim Declercq
Peter Vandenabeele
A1
Journal Article
in
FEBS LETTERS
2000
TTRAP, a novel protein that associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor-associated factors (TRAFs), and that inhibits nuclear factor-kappa B activation.
S PYPE
Wim Declercq
A IBRAHIMI
C MICHIELS
JGI VAN RIETSCHOTEN
N DEWULF
M DE BOER
Peter Vandenabeele
D HUYLEBROECK
JE REMACLE
A1
Journal Article
in
JOURNAL OF BIOLOGICAL CHEMISTRY
2000
Terminal differentiation of human keratinocytes and stratum corneum formation is associated with caspase-14 activation.
L ECKHART
Wim Declercq
J BAN
M RENDL
B LENGAUER
C MAYER
Saskia Lippens
Peter Vandenabeele
E TSCHACHLER
A1
Journal Article
in
JOURNAL OF INVESTIGATIVE DERMATOLOGY
2000
p38 mitogen-activated protein kinase regulates a novel, caspase-independent pathway for the mitochondrial cytochrome c release in ultraviolet B radiation-induced apoptosis.
Z ASSEFA
A VANTIEGHEM
M GARMYN
Wim Declercq
Peter Vandenabeele
JR VANDENHEEDE
R BOUILLON
W MERLEVEDE
P AGOSTINIS
A1
Journal Article
in
JOURNAL OF BIOLOGICAL CHEMISTRY
2000
1999
Identification of caspases that cleave presenilin-1 and presenilin-2 - Five presenilin-1 (PS1) mutations do not alter the sensitivity of PS1 to caspases.
Marc Van De Craen
C DE JONGHE
I VAN DEN BRANDE
Wim Declercq
G VAN GASSEN
Wim Van Criekinge
I VANDERHOEVEN
Walther Fiers
C VAN BROECKHOVEN
L HENDRIKS
et al.
A1
Journal Article
in
FEBS LETTERS
1999
Immunolocalization of tumor necrosis factor-alpha and its receptors in inflammatory myopathies.
Jan De Bleecker
VI MEIRE
Wim Declercq
EH VAN AKEN
A1
Journal Article
in
NEUROMUSCULAR DISORDERS
1999
More than one way to die: apoptosis, necrosis and reactive oxygen damage.
Walther Fiers
Rudi Beyaert
Wim Declercq
Peter Vandenabeele
A1
Journal Article
in
ONCOGENE
1999
Non-specific effects of methyl ketone peptide inhibitors of caspases.
Peter Schotte
Wim Declercq
Sofie Van Huffel
Peter Vandenabeele
Rudi Beyaert
A1
Journal Article
in
FEBS LETTERS
1999
Proteolytic cleavage of beta-catenin by caspases: an in vitro analysis.
Marc Van De Craen
Geert Berx
I VAN DEN BRANDE
Walther Fiers
Wim Declercq
Peter Vandenabeele
A1
Journal Article
in
FEBS LETTERS
1999
The activation of the c-Jun N-terminal kinase and p38 mitogen-activated protein kinase signaling pathways protects HeLa cells from apoptosis following photodynamic therapy with hypericin.
Z ASSEFA
A VANTIEGHEM
Wim Declercq
Peter Vandenabeele
JR VANDENHEEDE
W MERLEVEDE
P DE WITTE
P AGOSTINIS
A1
Journal Article
in
JOURNAL OF BIOLOGICAL CHEMISTRY
1999
The proteolytic procaspase activation network: an in vitro analysis.
Marc Van De Craen
Wim Declercq
I VAN DEN BRANDE
Walther Fiers
Peter Vandenabeele
A1
Journal Article
in
CELL DEATH AND DIFFERENTIATION
1999
1998
Cooperation of both TNF receptors in inducing apoptosis: Involvement of the TNF receptor-associated factor binding domain of the TNF receptor 75.
Wim Declercq
Geertrui Denecker
Walther Fiers
Peter Vandenabeele
A1
Journal Article
in
JOURNAL OF IMMUNOLOGY
1998
Dual signaling of the Fas receptor: Initiation of both apoptotic and necrotic cell death pathways.
Dominique Vercammen
Greet Brouckaert
Geertrui Denecker
Marc Van De Craen
Wim Declercq
Walther Fiers
Peter Vandenabeele
A1
Journal Article
in
JOURNAL OF EXPERIMENTAL MEDICINE
1998
Hypericin-induced photosensitization of HeLa cells leads to apoptosis or necrosis - Involvement of cytochrome c and procaspase-3 activation in the mechanism of apoptosis.
A VANTIEGHEM
Z ASSEFA
Peter Vandenabeele
Wim Declercq
S COURTOIS
JR VANDENHEEDE
W MERLEVEDE
P DE WITTE
P AGOSTINIS
A1
Journal Article
in
FEBS LETTERS
1998
Identification of a new caspase homologue: caspase-14.
Marc Van De Craen
Geert van Loo
S PYPE
Wim Van Criekinge
I VAN DEN BRANDE
Francis Molemans
Walther Fiers
Wim Declercq
Peter Vandenabeele
A1
Journal Article
in
CELL DEATH AND DIFFERENTIATION
1998
Inhibition of caspases increases the sensitivity of L929 cells to necrosis mediated by tumor necrosis factor.
Dominique Vercammen
Rudi Beyaert
Geertrui Denecker
Vera Goossens
Geert van Loo
Wim Declercq
Johan Grooten
Walther Fiers
Peter Vandenabeele
A1
Journal Article
in
JOURNAL OF EXPERIMENTAL MEDICINE
1998
Molecular cloning and identification of murine caspase-8.
M VAN DE CRAEN
Geert van Loo
Wim Declercq
P SCHOTTE
I VAN DEN BRANDE
S MANDRUZZATO
P VAN DER BRUGGEN
Walther Fiers
Peter Vandenabeele
A1
Journal Article
in
JOURNAL OF MOLECULAR BIOLOGY
1998
TRAF2 plays a dual role in NF-kappa B-dependent gene activation by mediating the TNF-induced activation of p38 MAPK and I kappa B kinase pathways.
Isabelle Carpentier
Wim Declercq
NL MALININ
D WALLACH
Walther Fiers
Rudi Beyaert
A1
Journal Article
in
FEBS LETTERS
1998
1997
Characterization of seven murine caspase family members
Marc Van de Craen
Peter Vandenabeele
Wim Declercq
Ilse Van den Brande
Geert van Loo
Francis Molemans
Peter Schotte
Wim Van Criekinge
Rudi Beyaert
Walther Fiers
A1
Journal Article
in
FEBS LETTERS
1997
Cleavage of caspase family members by granzyme B: A comparative study in vitro.
M VANDECRAEN
I VANDENBRANDE
Wim Declercq
M IRMLER
Rudi Beyaert
J TSCHOPP
Walther Fiers
Peter Vandenabeele
A1
Journal Article
in
EUROPEAN JOURNAL OF IMMUNOLOGY
1997
De 75 kDa TNF-receptor: rol in TNF-afhankelijke signalisatie leidend naar geninductie en apoptose
Wim Declercq
Walther Fiers
R. Contreras
Dissertation
1997
Differential role of calcium in tumour necrosis factor-mediated apoptosis and secretion of granulocyte-macrophage colony-stimulating factor in a T cell hybridoma.
Geertrui Denecker
Peter Vandenabeele
Johan Grooten
LC PENNING
Wim Declercq
Rudi Beyaert
WA BUURMAN
Walther Fiers
A1
Journal Article
in
CYTOKINE
1997
Tumour necrosis factor-induced necrosis versus anti-Fas-induced apoptosis in L929 cells.
Dominique Vercammen
Peter Vandenabeele
Rudi Beyaert
Wim Declercq
Walther Fiers
A1
Journal Article
in
CYTOKINE
1997
Tumour necrosis factor: intracellular mechanism of action
Walther Fiers
Rudi Beyaert
Elke Boone
Wim Declercq
Els Decoster
Dirk De Valck
Vera Goossens
Johan Grooten
Guy Haegeman
Karen Heyninck
et al.
Bookchapter
in
HIV and cytokines
1997
1996
TNF-induced intracellular signaling leading to gene induction or to cytotoxicity by necrosis or by apoptosis.
Walther Fiers
Rudi Beyaert
Elke Boone
Sigrid Cornelis
Wim Declercq
Els Decoster
Geertrui Denecker
Bart Depuydt
Dirk De Valck
G DEWILDE
et al.
A1
Journal Article
in
JOURNAL OF INFLAMMATION
1996
1995
2 TUMOR-NECROSIS-FACTOR RECEPTORS - STRUCTURE AND FUNCTION.
Peter Vandenabeele
Wim Declercq
Rudi Beyaert
Walther Fiers
A1
Journal Article
in
TRENDS IN CELL BIOLOGY
1995
BOTH TNF RECEPTORS ARE REQUIRED FOR TNF-MEDIATED INDUCTION OF APOPTOSIS IN PC60 CELLS.
Peter Vandenabeele
Wim Declercq
Bart Vanhaesebroeck
Johan Grooten
Walther Fiers
A1
Journal Article
in
JOURNAL OF IMMUNOLOGY
1995
Both TNF receptors are required for TNF-mediated induction of apoptosis in PC60 cells
Peter Vandenabeele
Wim Declercq
Bart Vanhaesebroeck
Johan Grooten
Walther Fiers
A2
Journal Article
in
J. Immunol.. 154, pp. 2904-2913
1995
Casein kinase-1 phosphorylates the p75 tumor-necrosis-factor receptor and negatively regulates tumor-necrosis-factor signaling for apoptosis.
Rudi Beyaert
Bart Vanhaesebroeck
Wim Declercq
J VANLINT
Peter Vandenabeele
P AGOSTINIS
JR VANDENHEEDE
Walther Fiers
A1
Journal Article
in
JOURNAL OF BIOLOGICAL CHEMISTRY
1995
Cytotoxicity in L929 murine fibrosarcoma cells after triggering of transfected human p75 tumour-necrosis-factor (TNF) receptor is mediated by endogenous murine TNF.
D VERCAMMEN
Peter Vandenabeele
Wim Declercq
M VANDECRAEN
Johan Grooten
Walther Fiers
A1
Journal Article
in
CYTOKINE
1995
Dimerization of chimeric erythropoietin 75 kDa tumour-necrosis-factor (TNF) receptors transduces TNF signals - Necessity for the 75 kDa TNF-receptor transmembrane domain.
Wim Declercq
Peter Vandenabeele
Walther Fiers
A1
Journal Article
in
CYTOKINE
1995
Two tumour necrosis factor receptors : structure and function
Peter Vandenabeele
Wim Declercq
Rudi Beyaert
Walther Fiers
A2
Journal Article
in
TRENDS IN CELL BIOLOGY
1995
1994
FUNCTIONAL REQUIREMENT OF THE 2 TNF RECEPTORS FOR INDUCTION OF APOPTOSIS IN PC60 CELLS AND THE ROLE OF MITOCHONDRIA IN TNF-INDUCED CYTOTOXICITY.
Peter Vandenabeele
V GOOSSENS
Rudi Beyaert
Wim Declercq
Johan Grooten
B VANHAESEBROECK
M VANDECRAEN
D VERCAMMEN
B DEPUYDT
G DENECKER
et al.
A1
Journal Article
in
CIRCULATORY SHOCK
1994
1993
Two pathways of tumor necrosis factor signal transduction: in vitro and in vivo implications
Walther Fiers
Rudi Beyaert
Peter Brouckaert
Anje Cauwels
Wim Declercq
Dirk De Valck
B Everaerdt
Vera Goossens
Johan Grooten
Guy Haegeman
et al.
C1
Conference
1993
1992
Functional characterization of the human tumor necrosis factor receptor p75 in a transfected rat/mouse T cell hybridoma
Peter Vandenabeele
Wim Declercq
Dominique Vercammen
Marc Van De Craen
Johan Grooten
Hansruedi Loetscher
Manfred Brockhaus
Werner Lesslauer
Walther Fiers
A1
Journal Article
in
JOURNAL OF EXPERIMENTAL MEDICINE
1992
1990
Development of a simple, sensitive and specific bioassay for interleukin-1 based on the proliferation of RPMI 1788 cells: comparison with other bioassays for IL-1
Peter Vandenabeele
Wim Declercq
Claude Libert
Walther Fiers
A1
Journal Article
in
JOURNAL OF IMMUNOLOGICAL METHODS
1990
Response of murine cell lines to an IL-1/IL-2 induced factor in a rat mouse T hybridoma (PC60) : differential induction of cytokines by human IL-1α and IL-1β and partial amino acid sequence of rat GM-CSF
Peter Vandenabeele
Yves Guisez
Wim Declercq
Guy Bauw
Joël Vandekerckhove
Walther Fiers
A1
Journal Article
in
LYMPHOKINE RESEARCH
1990
1987
Recombinant tumor necrosis factor can induce interleukin 2 receptor expression and cytolytic activity in a rat × mouse T cell hybrid
Geert Plaetinck
Wim Declercq
Jan Tavernier
Markus Nabholz
Walther Fiers
A1
Journal Article
in
EUROPEAN JOURNAL OF IMMUNOLOGY
1987