Research Explorer

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Researcher

Wim Declercq

Awards & Distinctions

166 Results

2024

Evolutionary origin of Hoxc13-dependent skin appendages in amphibians

Marjolein CarronAttila Placido SachslehnerMünevver Burcu CicekdalInge BruggemanSuzan DemuynckBahar GolabiElfride De BaereWim DeclercqErwin TschachlerKris Vleminckx et al.

A1 Journal Article in NATURE COMMUNICATIONS

RIPK1 protects naive and regulatory T cells from TNFR1-induced apoptosis

Jelle HuysentruytWolf SteelsMario Ruiz PérezBruno VerstraetenMike VadiTatyana DivertKayleigh FliesNozomi TakahashiBart LambrechtWim Declercq et al.

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

2023

Functions of the RIP kinase family members in the skin

Corinne UrwylerGiel TangheMichael DevosPaco HulpiauYvan SaeysWim Declercq

A1 Journal Article in CELLULAR AND MOLECULAR LIFE SCIENCES

2022

ADAR1 prevents autoinflammation by suppressing spontaneous ZBP1 activation

Richard de ReuverSimon VerdonckEvelien DierickJosephine NemegeerEline HessmannSadeem AhmadMaude JansGillian BlanckeFilip Van NieuwerburghAlexander Botzki et al.

A1 Journal Article in NATURE

Plasma membrane perforation by GSDME during apoptosis-driven secondary necrosis

Elke De SchutterJana RamonBenjamin PfeutyCaroline De TenderStephan StremerschKoen RaemdonckKen Op de BeeckWim DeclercqFranck RiquetKevin Braeckmans et al.

A1 Journal Article in CELLULAR AND MOLECULAR LIFE SCIENCES

Point mutation I634A in the glucocorticoid receptor causes embryonic lethality by reduced ligand binding

Steven TimmermansNicolette J.D. VerhoogKelly Van LooverenSylviane DewaeleTino HochepiedMelanie EggermontBarbara GilbertAnne Boerema-de MunckTineke VanderhaeghenJoke Vanden Berghe et al.

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

2021

Alternaria alternata and Aspergillus fumigatus mold species counteract experimental mycobacterial and allergic lung diseases through divergent innate immune mechanisms

Pauline LehebelOlivier DenisJohan GrootenWim Declercq

Characteristic ERK1/2 signaling dynamics distinguishes necroptosis from apoptosis

François SipieterBenjamin CappeAymeric LerayElke De SchutterJolien BridelancePaco HulpiauGuy Van CampWim DeclercqLaurent HeliotPierre Vincent et al.

A1 Journal Article in ISCIENCE

Loss of keratinocyte Mcpip1 abruptly activates the IL-23/Th17 and Stat3 pathways in skin inflammation

Agata Lichawska-CieslarPiotr KoniecznyWeronika SzukalaWim DeclercqMingui FuJolanta Jura

A1 Journal Article in BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

2020

Filaggrin expression and processing deficiencies impair corneocyte surface texture and stiffness in mice

Jacob P. ThyssenIvone JakasaChristoph RiethmüllerMichael P. SchönAndrea BraunMarek HaftekPadraic G. FallonJacek WróblewskiHieronim JakubowskiLeopold Eckhart et al.

A1 Journal Article in JOURNAL OF INVESTIGATIVE DERMATOLOGY

Immunodominant AH1 antigen-deficient necroptotic, but not apoptotic, murine cancer cells induce antitumor protection

Tania Love AaesHanne VerschuereAgnieszka KaczmarekLiesbeth HeyndrickxBartosz WiernickiIris DelrueBram De CraeneJoachim TaminauTinneke DelvaeyeMathieu Bertrand et al.

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Inhibitors targeting RIPK1/RIPK3 : old and new drugs

Sofie MartensSam HofmansWim DeclercqKoen AugustynsPeter Vandenabeele

A1 Journal Article in TRENDS IN PHARMACOLOGICAL SCIENCES

Mouse strain-dependent difference toward the staphylococcus aureus allergen serine protease-like protein D reveals a novel regulator of IL-33

Andrea Renate TeufelbergerSharon Van NevelPaco HulpiauMaria NordengrünSavvas SavvidesSarah De GraeveSrinivas AkulaGabriële HoltappelsNatalie De RuyckWim Declercq et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Sensing of endogenous nucleic acids by ZBP1 induces keratinocyte necroptosis and skin inflammation

Michael DevosGiel TangheBarbara GilbertEvelien DierickMaud VerheirstraetenJosephine NemegeerRichard de ReuverSylvie LefebvreJolien De MunckJan Rehwinkel et al.

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

2019

A20 protects cells from TNF-induced apoptosis through linear ubiquitin-dependent and -independent mechanisms

Dario PriemMichael DevosSarah DruwéArne MartensKarolina SlowickaAdrian T TingManolis PasparakisWim DeclercqPeter VandenabeeleGeert van Loo et al.

A1 Journal Article in CELL DEATH & DISEASE

Blocking connexin43 hemichannels protects mice against tumour necrosis factor-induced inflammatory shock

Tinneke DelvaeyeMaarten De SmetStijn VerwaerdeElke DecrockAleksandra CzekajRoosmarijn VandenbrouckeKelly LemeireAmanda GonçalvesWim DeclercqPeter Vandenabeele et al.

A1 Journal Article in SCIENTIFIC REPORTS

Delivery of mixed-lineage kinase domain-like protein by vapor nanobubble photoporation induces necroptotic-like cell death in tumor cells

Lien Van HoeckeLaurens RaesStephan StremerschToon BransJuan FraireRia RoelandtWim DeclercqPeter VandenabeeleKoen RaemdonckKevin Braeckmans et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Epithelial HMGB1 delays skin wound healing and drives tumor initiation by priming neutrophils for NET formation

Esther HosteChristian MaueröderLisette Van HoveLeen CatrysseHanna-Kaisa VikkulaMozes SzeBastiaan MaesDyah KarjosukarsoLiesbet MartensAmanda Gonçalves et al.

A1 Journal Article in CELL REPORTS

Keratinocyte expression of A20/TNFAIP3 controls skin inflammation associated with atopic dermatitis and psoriasis

Michael DevosDenis A MogilenkoSébastien FleuryBarbara GilbertCoralie BecquartSandrine QuemenerHélène DehondtPeter TougaardBart StaelsClaus Bachert et al.

A1 Journal Article in JOURNAL OF INVESTIGATIVE DERMATOLOGY

Keratinocyte-specific ablation of Mcpip1 impairs skin integrity and promotes local and systemic inflammation

Piotr KoniecznyAgata Lichawska-CieslarPatrycja KwiecinskaJoanna CichyRoza PietrzyckaWeronika SzukalaWim DeclercqMichael DevosAgnieszka PaziewskaIzabela Rumienczyk et al.

A1 Journal Article in JOURNAL OF MOLECULAR MEDICINE-JMM

Synthesis and evaluation of novel benzotropolones as Atg4B inhibiting autophagy blockers

Muhammet TancMatthias CleenewerckAmmar KurdiRia RoelandtWim DeclercqGuido De MeyerKoen AugustynsWim MartinetPieter Van der Veken

A1 Journal Article in BIOORGANIC CHEMISTRY

Walter Fiers (1931-2019) : obituary

Wim DeclercqPeter VandenabeeleXavier Saelens

2018

Keratinocyte-Specific Ablation of RIPK4 Allows Epidermal Cornification but Impairs Skin Barrier Formation

Corinne UrwylerGiel TangheKirsten LeursBarbara GilbertRiet De RyckeMichiel De BruyneSaskia LippensSona BartunkovaPhilippe De GrooteCarien Niessen et al.

A1 Journal Article in JOURNAL OF INVESTIGATIVE DERMATOLOGY

MLKL reveals its friendly face : a role in nerve regeneration

Peter VandenabeeleWim DeclercqRia RoelandtTom Vanden Berghe

Editorial material

Mechanistic insights into the regulation of RIPK4 and its function in skin homeostasis and pathology

Giel TangheWim Declercq

RIPK4 activity in keratinocytes is controlled by the SCFβ-TrCP ubiquitin ligase to maintain cortical actin organization

Giel TangheCorinne UrwylerPhilippe De GrooteEmmanuel DejardinPieter-Jan De BockKris GevaertPeter VandenabeeleWim Declercq

A1 Journal Article in CELLULAR AND MOLECULAR LIFE SCIENCES

The IL-33/ST2 axis is crucial in type 2 airway responses induced by Staphylococcus aureus-derived serine protease-like protein D

Andrea Renate TeufelbergerMaria NordengrünHarald BraunTania MaesKatrien De GroveGabriële HoltappelsClara O'BrienSharen ProvoostHamida HammadAmanda Gonçalves et al.

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

2017

ATG4B inhibitors with a benzotropolone core structure block autophagy and augment efficiency of chemotherapy in mice

Ammar KurdiMatthias CleenewerckChristel VangestelSophie LyssensWim DeclercqJean-Pierre TimmermansSigrid StroobantsKoen AugustynsGuido RY De MeyerPieter Van Der Veken et al.

A1 Journal Article in BIOCHEMICAL PHARMACOLOGY

Cell-type-specific chromatin states differentially prime squamous cell carcinoma tumor-initiating cells for epithelial to mesenchymal transition

Mathilde LatilDany NassarBenjamin BeckSoufiane BoumahdiLi WangAudrey BrisebarreChristine DuboisErwin NkusiSandrine LenglezAgnieszka Checinska et al.

A1 Journal Article in CELL STEM CELL

Elevated ΔNp63α levels facilitate epidermal and biliary oncogenic transformation

Michael DevosBarbara GilbertGeertrui DeneckerKirsten LeursConor Mc GuireKelly LemeireTino HochepiedMarnik VuylstekeJo LambertCaroline Van den Broecke et al.

A1 Journal Article in JOURNAL OF INVESTIGATIVE DERMATOLOGY

Feasibility study for clinical application of caspase-3 inhibitors in Pemphigus vulgaris

William VJ HaritonArnaud GalichetTom Vanden BergheAndrew M OvermillerMy G MahoneyWim DeclercqEliane J Müller

A1 Journal Article in EXPERIMENTAL DERMATOLOGY

Study of the functions of RIPK4 in epidermal development and signal transduction

Corinne UrwylerWim DeclercqPeter Vandenabeele

Varkens kweken waarop de Romeinen verzot waren

Edith Van WuytswinkelRuben BrabantBenedikt SasWim DeclercqHendrik Dierendonck

2016

Generation of a new Gateway-compatible inducible lentiviral vector platform allowing easy derivation of co-transduced cells

Philippe De GrooteSasker GrootjansSaskia LippensChantal EichpergerKirsten LeursIrene KahrGiel TangheInge BruggemanWouter De SchamphelaireCorinne Urwyler et al.

A1 Journal Article in BIOTECHNIQUES

Inhibitor screening and enzymatic activity determination for autophagy target Atg4B using a gel electrophoresis-based assay

Matthias CleenewerckMandy OJ GrootaertRafaela GladyszYves AdriaenssensRia RoelandtJurgen JoossensAnne-Marie LambeirGuido RY De MeyerWim DeclercqKoen Augustyns et al.

A1 Journal Article in EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Martin Leverkus, MD (1965-2016) : in memoriam

Diana Panayotova-DimitrovaWim Declercq

Vaccination with necroptotic cancer cells induces efficient anti-tumor immunity

Tania Love AaesAgnieszka KaczmarekTinneke DelvaeyeBram De CraeneStefaan De KokerLiesbeth HeyndrickxIris DelrueJoachim TaminauBartosz WiernickiPhilippe De Groote et al.

A1 Journal Article in CELL REPORTS

2015

A novel RIPK4-IRF6 connection is required to prevent epithelial fusions characteristic for popliteal pterygium syndromes

Philippe De GrooteHong Tran ThiMathias FransenGiel TangheCorinne UrwylerBram De CraeneKirsten LeursBarbara GilbertGriet Van ImschootRiet De Rycke et al.

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Interaction of Mycobacterium leprae with the HaCaT human keratinocyte cell line: new frontiers in the cellular immunology of leprosy

Eloah CD LyrioIvy C Campos-SouzaLuiz CD CorrêaGuilherme C LechugaMauricio VerícimoHelena C CastroSaulo C BourguignonSuzana Côrte-RealNorman RatcliffeWim Declercq et al.

A1 Journal Article in EXPERIMENTAL DERMATOLOGY

2014

Deregulation of the replisome factor MCMBP prompts oncogenesis in colorectal carcinomas through chromosomal instability

Mauricio Quimbaya GomezEric RaspéGeertrui DeneckerBram De CraeneRia RoelandtWim DeclercqXavier SagaertLieven De VeylderGeert Berx

A1 Journal Article in NEOPLASIA

MLKL compromises plasma membrane integrity by binding to phosphatidylinositol phosphates

Yves DondelingerWim DeclercqSylvie MontessuitRia RoelandtAmanda GonçalvesInge BruggemanPaco HulpiauKathrin WeberClark A SehonRobert W Marquis et al.

A1 Journal Article in CELL REPORTS

RIPK1 ensures intestinal homeostasis by protecting the epithelium against apoptosis

Nozomi TakahashiLars VereeckeMathieu BertrandLinde DuprezScott B BergerTatyana DivertAmanda GonçalvesMozes SzeBarbara GilbertStephanie Kourula et al.

A1 Journal Article in NATURE

Simultaneous targeting of IL-1 and IL-18 is required for protection against inflammatory and septic shock

Tom Vanden BergheDieter DemonPieter BogaertBenjamin VandendriesscheAlain GoethalsBart DepuydtMarnik VuylstekeRia RoelandtElien Van WonterghemJill Vandenbroecke et al.

A1 Journal Article in AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The skin microbiome of caspase-14-deficient mice shows mild dysbiosis

Malgorzata KubicaFalk HildebrandBrigitta BrinkmanDirk GoossensJurgen Del FaveroKen VercammenPierre CornelisJens-Michael SchröderPeter VandenabeeleJeroen Raes et al.

A1 Journal Article in EXPERIMENTAL DERMATOLOGY

2013

CDK4 T172 phosphorylation is central in a CDK7-dependent bidirectional CDK4/CDK2 interplay mediated by p21 phosphorylation at the restriction point

Xavier BisteauSabine PaternotBianca ColleoniKarin EckerKatia CoulonvalPhilippe De GrooteWim DeclercqLudger HengstPierre P Roger

A1 Journal Article in PLOS GENETICS

Bookchapter in Handbook of proteolytic enzymes

Caspase-14 overexpression in hairless mice is not involved in utricle formation

Michael DevosPhilippe De GrooteBarbara GilbertInge BruggemanKirsten LeursSaskia LippensPeter VandenabeeleWim Declercq

A1 Journal Article in EXPERIMENTAL DERMATOLOGY

Caspase-14-deficient mice are more prone to the development of parakeratosis

Esther HosteGeertrui DeneckerBarbara GilbertFilip Van NieuwerburghLeslie van der FitsBob AsselberghRiet De RyckeJean-Pierre HachemDieter DeforceErrol P Prens et al.

A1 Journal Article in JOURNAL OF INVESTIGATIVE DERMATOLOGY

Cell death by cornification

Leopold EckhartSaskia LippensErwin TschachlerWim Declercq

A1 Journal Article in BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Compound A, a selective glucocorticoid receptor modulator, enhances heat shock protein Hsp70 gene promoter activation

Ilse BeckZuzanna DrebertRuben Hoya-AriasAli A BaharMichael DevosDorien ClarisseSofie DesmetNadia BougarneBart RuttensValerie Gossye et al.

A1 Journal Article in PLOS ONE

2012

Filaggrin degradation by caspase-14 is required for UVB photoprotection but does not influence allergic sensitization in a mouse model of atopic dermatitis

Michael DevosJanne PrawittDelphine Staumont-SalleEsther HosteSebastién FleuryEmmanuel BouchaertBarbara GilbertSaskia LippensPeter VandenabeeleDavid Dombrowicz et al.

A1 Journal Article in JOURNAL OF INVESTIGATIVE DERMATOLOGY

Necrostatin-1 analogues: critical issues on the specificity, activity and in vivo use in experimental disease models

Nozomi TakahashiLinde DuprezSasker GrootjansAnje CauwelsWim NerinckxJB DuHadawayVera GoossensRia RoelandtFilip Van HauwermeirenClaude Libert et al.

A1 Journal Article in CELL DEATH & DISEASE

Study of RIPK4 function in skin homeostasis and disease

Philippe De GrooteWim DeclercqSaskia LippensPeter Vandenabeele

Study on the role of ΔNp63α and caspase-14 in skin homeostasis and pathology

Michael DevosWim DeclercqPeter Vandenabeele

2011

18th Euroconference on Apoptosis in Ghent, Belgium, 1-4 September 2010

Wim DeclercqP AgostinisPeter Vandenabeele

Editorial material

Caspase deficiency alters the murine gut microbiome

Brigitta BrinkmanF HildebrandMalgorzata KubicaD GoosensJ Del FaveroWim DeclercqJ RaesPeter Vandenabeele

A1 Journal Article in CELL DEATH & DISEASE

Caspase-14 is required for filaggrin degradation to natural moisturizing factors in the skin

Esther HostePatrick KempermanMichael DevosGeertrui DeneckerSanja KezicNico YauBarbara GilbertSaskia LippensPhilippe De GrooteRia Roelandt et al.

A1 Journal Article in JOURNAL OF INVESTIGATIVE DERMATOLOGY

Cell death in the skin

Saskia LippensEsther HostePeter VandenabeeleWim Declercq

Bookchapter in Apoptosis : physiology and pathology

Dual face apoptotic machinery: from initiator of apoptosis to guardian of necroptosis

Wim DeclercqNozomi TakahashiPeter Vandenabeele

Editorial material

Inhibition of kallikrein-related peptidases by the serine protease inhibitor of Kazal-type 6

Tomasz KantykaJan FischerZhihong WuWim DeclercqKarina ReissJens-Michael SchröderUlf Meyer-Hoffert

A1 Journal Article in PEPTIDES

Keratinocyte-specific ablation of the NF-κB regulatory protein A20 (TNFAIP3) reveals a role in the control of epidermal homeostasis

Saskia LippensS LefebvreBarbara GilbertMozes SzeMichael DevosKelly VerhelstLars VereeckeConor Mc GuireChris GuerinPeter Vandenabeele et al.

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

RIP Kinase-dependent necrosis drives lethal systemic inflammatory response syndrome

Linde DuprezNozomi TakahashiFilip Van HauwermeirenBenjamin VandendriesscheVera GoossensTom Vanden BergheWim DeclercqClaude LibertAnje CauwelsPeter Vandenabeele

A1 Journal Article in IMMUNITY

cIAP1/2 are direct E3 ligases conjugating diverse types of ubiquitin chains to receptor interacting proteins kinases 1 to 4 (RIP1-4)

Mathieu BertrandSaskia LippensAn StaesBarbara GilbertRia RoelandtJelle De MedtsKris GevaertWim DeclercqPeter Vandenabeele

A1 Journal Article in PLOS ONE

p63, a story of mice and men

Hans VanbokhovenGerry MelinoEleonora CandiWim Declercq

A1 Journal Article in JOURNAL OF INVESTIGATIVE DERMATOLOGY

2010

Caspase-mediated cleavage of Beclin-1 inactivates Beclin-1-induced autophagy and enhances apoptosis by promoting the release of proapoptotic factors from mitochondria

Ellen WirawanLieselotte Vande WalleKristof KersseSigrid CornelisS ClaerhoutIsabel VanoverbergheRia RoelandtRiet De RyckeJelle VerspurtenWim Declercq et al.

A1 Journal Article in CELL DEATH & DISEASE

Caspases in epidermal differentiation and cornification

Editorial material

Necroptosis, necrosis and secondary necrosis converge on similar cellular disintegration features

Tom Vanden BergheNele VanlangenakkerEef ParthoensWies DeckersMichael DevosNele FestjensChris GuerinUT BrunkWim DeclercqPeter Vandenabeele

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Study of the role of caspase-14 in epidermal cornification

Esther HosteWim DeclercqPeter Vandenabeele

The role of the kinases RIP1 and RIP3 in TNF-induced necrosis

Peter VandenabeeleWim DeclercqFranky Van HerrewegheTom Vanden Berghe

A1 Journal Article in SCIENCE SIGNALING

Tumor necrosis factor-mediated cell death: to break or to burst, that's the question

Franky Van HerrewegheNele FestjensWim DeclercqPeter Vandenabeele

A1 Journal Article in CELLULAR AND MOLECULAR LIFE SCIENCES

2009

Caspase substrates: easily caught in deep waters?

Dieter DemonPetra Van DammeTom Vanden BergheJoël VandekerckhoveWim DeclercqKris GevaertPeter Vandenabeele

A1 Journal Article in TRENDS IN BIOTECHNOLOGY

Cell death in the skin

Saskia LippensEsther HostePeter VandenabeelePatrizia AgostinisWim Declercq

A1 Journal Article in APOPTOSIS

Death receptor-induced necroptosis

Wim DeclercqFranky Van HerrewegheTom Vanden BerghePeter Vandenabeele

Bookchapter in Encyclopedia of life sciences

Function of caspase-14 in trophoblast differentiation

LJ WhiteWim DeclercqF ArfusoAK CharlesAM Dharmarajan

A1 Journal Article in REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY

Proteome-wide substrate analysis indicates substrate exclusion as a mechanism to generate caspase-7 versus caspase-3 specificity

Dieter DemonPetra Van DammeTom Vanden BergheAnnelies DeceuninckJoost Van DurmeJelle VerspurtenKenny HelsensFrancis ImpensMagdalena WejdaJoost Schymkowitz et al.

A1 Journal Article in MOLECULAR & CELLULAR PROTEOMICS

RIP Kinases at the Crossroads of Cell Death and Survival

Wim DeclercqTom Vanden BerghePeter Vandenabeele

A1 Journal Article in CELL

SitePredicting the cleavage of proteinase substrates

Jelle VerspurtenKris GevaertWim DeclercqPeter Vandenabeele

A1 Journal Article in TRENDS IN BIOCHEMICAL SCIENCES

The "Caveolae Brake Hypothesis" and the Epidermal Barrier

Truus RoelandtChristina GiddeloCarol HeughebaertGeertrui DeneckerMelanie HupeDebra CrumrineAndy KusumaMarek HaftekDiane RosseeuwWim Declercq et al.

A1 Journal Article in JOURNAL OF INVESTIGATIVE DERMATOLOGY

The emerging roles of serine protease cascades in the epidermis

Petra OvaereSaskia LippensPeter VandenabeeleWim Declercq

A1 Journal Article in TRENDS IN BIOCHEMICAL SCIENCES

2008

Acute modulations in permeability barrier function regulate epidermal cornification - Role of caspase-14 and the protease activated receptor type 2

M DEMERJIANJP HACHEME TSCHACHLERGeertrui DeneckerWim DeclercqPeter VandenabeeleT MAUROM HUPED CRUMRINET ROELANDT et al.

A1 Journal Article in AMERICAN JOURNAL OF PATHOLOGY

Apoptosome and caspase activation

Wim DeclercqPeter Vandenabeele

Bookchapter in Wiley Encyclopedia of Chemical Biology

Caspase-14 reveals its secrets

Geertrui DeneckerPetra OvaerePeter VandenabeeleWim Declercq

A1 Journal Article in JOURNAL OF CELL BIOLOGY

Kristof KersseWim DeclercqPeter Vandenabeele

Bookchapter in Encyclopedia of molecular pharmacology

Necrotic cell death and 'necrostatins': now we can control cellular explosion

Peter VandenabeeleWim DeclercqTom Vanden Berghe

A1 Journal Article in TRENDS IN BIOCHEMICAL SCIENCES

Role of Caspases in inflammation-driven diseases

Kristof KersseTom Vanden BergheSaskia LippensWim DeclercqPeter Vandenabeele

Bookchapter in Design of Caspase inhibitors as potential clinical agents

2007

Are metacaspases caspases?

Dominique VercammenWim DeclercqPeter VandenabeeleFrank Van Breusegem

A1 Journal Article in JOURNAL OF CELL BIOLOGY

Caspase-14 protects against epidermal UVB photo-damage and water loss

Geertrui DeneckerEsther HosteBarbara GilbertTino HochepiedPetra OvaereSaskia LippensC VAN DEN BROUCKEPetra Van DammeKatharina D'HerdeJ HACHEM et al.

Caspase-14 protects against epidermal UVB photo-damage and water loss.

Geertrui DeneckerEsther HosteBarbara GilbertTino HochepiedPetra OvaereSaskia LippensC VAN DEN BROUCKEPetra Van DammeKatharina D'HerdeJ HACHEM et al.

Caspase-14 protects against epidermal UVB photodamage and water loss

Geertrui DeneckerEsther HosteBarbara GilbertTino HochepiedPetra OvaereSaskia LippensCaroline Van den broeckePetra Van DammeKatharina D'HerdeJP HACHEM et al.

A1 Journal Article in NATURE CELL BIOLOGY

Caspases in cell survival, proliferation and differentiation

Mohamed LamkanfiNele FestjensWim DeclercqTom Vanden BerghePeter Vandenabeele

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Generation of active recombinant human caspase-14

Philippe De GrootePetra OvaereEsther HosteGeertrui DeneckerSaskia LippensPeter VandenabeeleWim Declercq

Identification and characterization of filaggrin as a caspase-14 substrate

Esther HosteGeertrui DeneckerPetra Van DammeRB PRESLANDJoël VandekerckhoveKris GevaertPeter VandenabeeleWim Declercq

NADPH oxidases: new players in TNIF-induced necrotic cell death

Tom Vanden BergheWim DeclercqPeter Vandenabeele

Editorial material

Permeability barrier requirements regulate keratinocyte cornification: role of caspase 14 and the protease-activated receptor type 2

M DEMERJIANJ HACHEME TSCHACHLERGeertrui DeneckerWim DeclercqPeter VandenabeeleTM MAUROD CRUMRINET ROELANDTE HOUBEN et al.

2006

Caspases leave the beaten track: caspase-mediated activation of NF-kappa B

Mohamed LamkanfiWim DeclercqTom Vanden BerghePeter Vandenabeele

A1 Journal Article in JOURNAL OF CELL BIOLOGY

Role of caspase-14 in terminal differentiation of keratinocytes

Geertrui DeneckerEsther HosteBarbara GilbertTino HochepiedPetra OvaereSaskia LippensCaroline VandenbrouckeKatharina D'HerdePeter VandenabeeleWim Declercq

The secret life of caspase-14

Geertrui DeneckerEsther HosteT HOCHPIEDBarbara GilbertPetra OvaereKatharina D'HerdeCaroline VandenbrouckeSaskia LippensLore SchoonjansClaude Libert et al.

2005

A novel caspase-2 complex containing TRAF2 and RIP1

Mohamed LamkanfiKathleen D'HondtLieselotte Vande WalleMaria (Marjan) van GurpGeertrui DeneckerJill DemeulemeesterMichaël KalaiWim DeclercqXavier SaelensPeter Vandenabeele

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Caspase-14 but not caspase-3 is processed during the development of fetal mouse epidermis

H FISCHERH ROSSITERM GHANNADANK JAEGERC BARRESIWim DeclercqE TSCHACHLERL ECKHART

A1 Journal Article in DIFFERENTIATION

Death penalty for keratinocytes: apoptosis versus cornification

Saskia LippensGeertrui DeneckerPetra OvaerePeter VandenabeeleWim Declercq

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Induction of apoptosis by TNF receptor 2 in a T-cell hybridoma is FADD dependent and blocked by caspase-8 inhibitors

Bart DepuydtGeert van LooPeter VandenabeeleWim Declercq

A1 Journal Article in JOURNAL OF CELL SCIENCE

Requirement for tumor necrosis factor-receptor 2 in alveolar chemokine expression depends upon the form of the ligand

J LiuMQ ZhaoLM XuCV RamanaWim DeclercqPeter VandenabeeleRI Enelow

A1 Journal Article in AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

2004

Activation of p38 MAPK is required for Bax translocation to mitochondria, cytochrome c release and apoptosis induced by UVB irradiation in human keratinocytes

A VAN LAETHEMS VAN KELSTSaskia LippensWim DeclercqPeter VandenabeeleS JANSSENSJR VANDENHEEDEM GARMYNP AGOSTINIS

A1 Journal Article in FASEB JOURNAL

Caspase-1 activates nuclear factor of the kappa-enhancer in B cells independently of its enzymatic activity

Mohamed LamkanfiMichaël KalaiXavier SaelensWim DeclercqPeter Vandenabeele

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Cleavage of caspase-14 coincides with stratum corneum formation during development of fetal mouse skin

H FISCHERL ECKHARTC BARESIM GHANNADANH ROSSITERM BUCHBERGERSaskia LippensWim DeclercqE TSCHACHLER

Differential signaling to apoptotic and necrotic cell death by Fas-associated death domain protein FADD

Tom Vanden BergheGeert van LooXavier SaelensMaria (Marjan) van GurpGreet BrouckaertMichaël KalaiWim DeclercqPeter Vandenabeele

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

INCA, a novel human caspase recruitment domain protein that inhibits interleukin-1 beta generation

Mohamed LamkanfiGeertrui DeneckerMichaël KalaiKathleen D'HondtAnn MeeusWim DeclercqXavier SaelensPeter Vandenabeele

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Stratum corneum-derived caspase-14 is catalytically active

H FISCHERM STICHENWIRTHM DOCKALM GHANNADANM BUCHBERGERJ BACHA KAPETANOPOULOSWim DeclercqE TSCHACHLERL ECKHART

A1 Journal Article in FEBS LETTERS

Vitamin D3 induces caspase-14 expression in psoriatic lesions and enhances caspase-14 processing in organotypic skin cultures

Saskia LippensM KOCKXGeertrui DeneckerM KNAAPENA VERHEYENR CHRISTIAENE TSCHACHLERPeter VandenabeeleWim Declercq

A1 Journal Article in AMERICAN JOURNAL OF PATHOLOGY

2003

A Bcl-2 transgene expressed in hepatocytes does not protect mice from fulminant liver destruction induced by Fas ligand

Geert van LooSaskia LippensM HAHNEFilip MatthijssensWim DeclercqXavier SaelensPeter Vandenabeele

A1 Journal Article in CYTOKINE

Caspase-14 is expressed in the epidermis, the choroid plexus, the retinal pigment epithelium and thymic Hassall's bodies

Saskia LippensCaroline Van den BroeckeElke Van DammeE TschachlerPeter VandenabeeleWim Declercq

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Disruption of HSP90 function reverts tumor necrosis factor-induced necrosis to apoptosis

Tom Vanden BergheMichaël KalaiGeert van LooWim DeclercqPeter Vandenabeele

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of the expression and processing of caspase-12

Michaël KalaiMohamed LamkanfiGeertrui DeneckerM BoogmansSaskia LippensAnn MeeusWim DeclercqPeter Vandenabeele

A1 Journal Article in JOURNAL OF CELL BIOLOGY

The caspase family

Mohamed LamkanfiWim DeclercqBart DepuydtMichaël KalaiXavier SaelensPeter Vandenabeele

Bookchapter in Caspases-Their Role in Cell Death and Cell Survival

2002

A matrix-assisted laser desorption ionization post-source decay (MALDI-PSD) analysis of proteins released from isolated liver mitochondria treated with recombinant truncated Bid

Geert van LooHans DemolMaria (Marjan) van GurpB HoorelbekePeter SchotteRudi BeyaertB ZhivotovskyKris GevaertWim DeclercqJoël Vandekerckhove et al.

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Alice in caspase land. A phylogenetic analysis of caspases from worm to man.

Mohamed LamkanfiWim DeclercqMichaël KalaiXavier SaelensPeter Vandenabeele

Editorial material

Caspases are not localized in mitochondria during life or death

Geert van LooXavier SaelensFilip MatthijssensPeter SchotteRudi BeyaertWim DeclercqPeter Vandenabeele

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

The serine protease Omi/HtrA2 is released from mitochondria during apoptosis. Omi interacts with caspase-inhibitor XIAP and induces enhanced caspase activity.

Geert van LooMaria (Marjan) van GurpBart DepuydtSM SRINIVASULAI RODRIGUEZES ALNEMRIKris GevaertJoël VandekerckhoveWim DeclercqPeter Vandenabeele

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

2001

Apoptotic and necrotic cell death induced by death domain receptors.

Geertrui DeneckerD VERCAMMENWim DeclercqPeter Vandenabeele

A1 Journal Article in CELLULAR AND MOLECULAR LIFE SCIENCES

Death receptor-induced apoptotic and necrotic cell death: differential role of caspases and mitochondria.

Geertrui DeneckerD VERCAMMENMargino SteemansTom Vanden BergheGreet BrouckaertGeert van LooB ZHIVOTOVSKYWalter FiersJohan GrootenWim Declercq et al.

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Endonuclease G: a mitochondrial protein released in apoptosis and involved in caspaseindependent DNA degradation

Geert van LooPeter SchotteMaria (Marjan) van GurpHans DemolB HOORELBEKEKris GevaertI RODRIGUEZA RUIZ-CARRILLOJoël VandekerckhoveWim Declercq et al.

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Heterotrimers formed by tumor necrosis factors of different species or muteins.

Paul AmelootWim DeclercqWalter FiersPeter VandenabeelePeter Brouckaert

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Mouse mammary gland involution is associated with cytochrome c release and caspase activation.

A MARTIPM RITTERR JAGERH LAZARA BALTZERJ SCHENKELWim DeclercqPeter VandenabeeleR JAGGI

A1 Journal Article in MECHANISMS OF DEVELOPMENT

The somatostatin analogue TT-232 induces apoptosis in A431 cells - Sustained activation of stress-activated kinases and inhibition of signalling to extracellular signal-regulated kinases.

T VANTUSG KERIZ KRIVICKIENEM VALIUSA STETAKS KEPPENSP CSERMELYPI BAUERG BOKONYIWim Declercq et al.

A1 Journal Article in CELLULAR SIGNALLING

Yersinia enterocolitica YopP-induced apoptosis of macrophages involves the apoptotic signaling cascade upstream of Bid.

Geertrui DeneckerWim DeclercqC GEUIJENA BOLANDR BENABDILLAHMaria (Marjan) van GurpMP SORYPeter VandenabeeleGR CORNELIS

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

2000

A role for potassium in TNF-induced apoptosis and gene-induction in human and rodent tumour cell lines.

LC PENNINGGeertrui DeneckerD VERCAMMENWim DeclercqRG SCHIPPERPeter Vandenabeele

A1 Journal Article in CYTOKINE

Cloning and expression of cytokine genes

Wim DeclercqMarc LoggheWalter FiersRoland Contreras

Bookchapter in Cytokine molecular biology : a practical approach

Epidermal differentiation does not involve the pro-apoptotic executioner caspases, but is associated with caspase-14 induction and processing.

Saskia LippensM KOCKXM KNAAPENL MORTIERR POLAKOWSKAA VERHEYENM GARMYNA ZWIJSENP FORMSTECHERD HUYLEBROECK et al.

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Phosphatidyl serine exposure during apoptosis precedes release of cytochrome c and decrease in mitochondrial transmembrane potential.

Geertrui DeneckerHans DoomsGeert van LooD VERCAMMENJohan GrootenWalter FiersWim DeclercqPeter Vandenabeele

A1 Journal Article in FEBS LETTERS

TTRAP, a novel protein that associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor-associated factors (TRAFs), and that inhibits nuclear factor-kappa B activation.

S PYPEWim DeclercqA IBRAHIMIC MICHIELSJGI VAN RIETSCHOTENN DEWULFM DE BOERPeter VandenabeeleD HUYLEBROECKJE REMACLE

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Terminal differentiation of human keratinocytes and stratum corneum formation is associated with caspase-14 activation.

L ECKHARTWim DeclercqJ BANM RENDLB LENGAUERC MAYERSaskia LippensPeter VandenabeeleE TSCHACHLER

A1 Journal Article in JOURNAL OF INVESTIGATIVE DERMATOLOGY

p38 mitogen-activated protein kinase regulates a novel, caspase-independent pathway for the mitochondrial cytochrome c release in ultraviolet B radiation-induced apoptosis.

Z ASSEFAA VANTIEGHEMM GARMYNWim DeclercqPeter VandenabeeleJR VANDENHEEDER BOUILLONW MERLEVEDEP AGOSTINIS

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

1999

Identification of caspases that cleave presenilin-1 and presenilin-2 - Five presenilin-1 (PS1) mutations do not alter the sensitivity of PS1 to caspases.

Marc Van De CraenC DE JONGHEI VAN DEN BRANDEWim DeclercqG VAN GASSENWim Van CriekingeI VANDERHOEVENWalter FiersC VAN BROECKHOVENL HENDRIKS et al.

A1 Journal Article in FEBS LETTERS

Immunolocalization of tumor necrosis factor-alpha and its receptors in inflammatory myopathies.

Jan De BleeckerVI MEIREWim DeclercqEH VAN AKEN

A1 Journal Article in NEUROMUSCULAR DISORDERS

More than one way to die: apoptosis, necrosis and reactive oxygen damage.

Walter FiersRudi BeyaertWim DeclercqPeter Vandenabeele

A1 Journal Article in ONCOGENE

Non-specific effects of methyl ketone peptide inhibitors of caspases.

Peter SchotteWim DeclercqSofie Van HuffelPeter VandenabeeleRudi Beyaert

A1 Journal Article in FEBS LETTERS

Proteolytic cleavage of beta-catenin by caspases: an in vitro analysis.

Marc Van De CraenGeert BerxI VAN DEN BRANDEWalter FiersWim DeclercqPeter Vandenabeele

A1 Journal Article in FEBS LETTERS

The activation of the c-Jun N-terminal kinase and p38 mitogen-activated protein kinase signaling pathways protects HeLa cells from apoptosis following photodynamic therapy with hypericin.

Z ASSEFAA VANTIEGHEMWim DeclercqPeter VandenabeeleJR VANDENHEEDEW MERLEVEDEP DE WITTEP AGOSTINIS

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

The proteolytic procaspase activation network: an in vitro analysis.

Marc Van De CraenWim DeclercqI VAN DEN BRANDEWalter FiersPeter Vandenabeele

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

1998

Cooperation of both TNF receptors in inducing apoptosis: Involvement of the TNF receptor-associated factor binding domain of the TNF receptor 75.

Wim DeclercqGeertrui DeneckerWalter FiersPeter Vandenabeele

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Dual signaling of the Fas receptor: Initiation of both apoptotic and necrotic cell death pathways.

Dominique VercammenGreet BrouckaertGeertrui DeneckerMarc Van De CraenWim DeclercqWalter FiersPeter Vandenabeele

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

Hypericin-induced photosensitization of HeLa cells leads to apoptosis or necrosis - Involvement of cytochrome c and procaspase-3 activation in the mechanism of apoptosis.

A VANTIEGHEMZ ASSEFAPeter VandenabeeleWim DeclercqS COURTOISJR VANDENHEEDEW MERLEVEDEP DE WITTEP AGOSTINIS

A1 Journal Article in FEBS LETTERS

Identification of a new caspase homologue: caspase-14.

Marc Van De CraenGeert van LooS PYPEWim Van CriekingeI VAN DEN BRANDEFrancis MolemansWalter FiersWim DeclercqPeter Vandenabeele

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Inhibition of caspases increases the sensitivity of L929 cells to necrosis mediated by tumor necrosis factor.

Dominique VercammenRudi BeyaertGeertrui DeneckerVera GoossensGeert van LooWim DeclercqJohan GrootenWalter FiersPeter Vandenabeele

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

Molecular cloning and identification of murine caspase-8.

M VAN DE CRAENGeert van LooWim DeclercqP SCHOTTEI VAN DEN BRANDES MANDRUZZATOP VAN DER BRUGGENWalter FiersPeter Vandenabeele

A1 Journal Article in JOURNAL OF MOLECULAR BIOLOGY

TRAF2 plays a dual role in NF-kappa B-dependent gene activation by mediating the TNF-induced activation of p38 MAPK and I kappa B kinase pathways.

Isabelle CarpentierWim DeclercqNL MALININD WALLACHWalter FiersRudi Beyaert

A1 Journal Article in FEBS LETTERS

1997

Characterization of seven murine caspase family members

Marc Van de CraenPeter VandenabeeleWim DeclercqIlse Van den BrandeGeert van LooFrancis MolemansPeter SchotteWim Van CriekingeRudi BeyaertWalter Fiers

A1 Journal Article in FEBS LETTERS

Cleavage of caspase family members by granzyme B: A comparative study in vitro.

M VANDECRAENI VANDENBRANDEWim DeclercqM IRMLERRudi BeyaertJ TSCHOPPWalter FiersPeter Vandenabeele

A1 Journal Article in EUROPEAN JOURNAL OF IMMUNOLOGY

De 75 kDa TNF-receptor: rol in TNF-afhankelijke signalisatie leidend naar geninductie en apoptose

Wim DeclercqWalter FiersR. Contreras

Differential role of calcium in tumour necrosis factor-mediated apoptosis and secretion of granulocyte-macrophage colony-stimulating factor in a T cell hybridoma.

Geertrui DeneckerPeter VandenabeeleJohan GrootenLC PENNINGWim DeclercqRudi BeyaertWA BUURMANWalter Fiers

A1 Journal Article in CYTOKINE

Tumour necrosis factor-induced necrosis versus anti-Fas-induced apoptosis in L929 cells.

Dominique VercammenPeter VandenabeeleRudi BeyaertWim DeclercqWalter Fiers

A1 Journal Article in CYTOKINE

Tumour necrosis factor: intracellular mechanism of action

Walter FiersRudi BeyaertElke BooneWim DeclercqEls DecosterDirk De ValckVera GoossensJohan GrootenGuy HaegemanKaren Heyninck et al.

Bookchapter in HIV and cytokines

1996

TNF-induced intracellular signaling leading to gene induction or to cytotoxicity by necrosis or by apoptosis.

Walter FiersRudi BeyaertElke BooneSigrid CornelisWim DeclercqEls DecosterGeertrui DeneckerBart DepuydtDirk De ValckG DEWILDE et al.

A1 Journal Article in JOURNAL OF INFLAMMATION

1995

2 TUMOR-NECROSIS-FACTOR RECEPTORS - STRUCTURE AND FUNCTION.

Peter VandenabeeleWim DeclercqRudi BeyaertWalter Fiers

A1 Journal Article in TRENDS IN CELL BIOLOGY

BOTH TNF RECEPTORS ARE REQUIRED FOR TNF-MEDIATED INDUCTION OF APOPTOSIS IN PC60 CELLS.

Peter VandenabeeleWim DeclercqBart VanhaesebroeckJohan GrootenWalter Fiers

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Both TNF receptors are required for TNF-mediated induction of apoptosis in PC60 cells

Peter VandenabeeleWim DeclercqBart VanhaesebroeckJohan GrootenWalter Fiers

A2 Journal Article in J. Immunol.. 154, pp. 2904-2913

Casein kinase-1 phosphorylates the p75 tumor-necrosis-factor receptor and negatively regulates tumor-necrosis-factor signaling for apoptosis.

Rudi BeyaertBart VanhaesebroeckWim DeclercqJ VANLINTPeter VandenabeeleP AGOSTINISJR VANDENHEEDEWalter Fiers

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Cytotoxicity in L929 murine fibrosarcoma cells after triggering of transfected human p75 tumour-necrosis-factor (TNF) receptor is mediated by endogenous murine TNF.

D VERCAMMENPeter VandenabeeleWim DeclercqM VANDECRAENJohan GrootenWalter Fiers

A1 Journal Article in CYTOKINE

Dimerization of chimeric erythropoietin 75 kDa tumour-necrosis-factor (TNF) receptors transduces TNF signals - Necessity for the 75 kDa TNF-receptor transmembrane domain.

Wim DeclercqPeter VandenabeeleWalter Fiers

A1 Journal Article in CYTOKINE

Two tumour necrosis factor receptors : structure and function

Peter VandenabeeleWim DeclercqRudi BeyaertWalter Fiers

A2 Journal Article in TRENDS IN CELL BIOLOGY

1994

FUNCTIONAL REQUIREMENT OF THE 2 TNF RECEPTORS FOR INDUCTION OF APOPTOSIS IN PC60 CELLS AND THE ROLE OF MITOCHONDRIA IN TNF-INDUCED CYTOTOXICITY.

Peter VandenabeeleV GOOSSENSRudi BeyaertWim DeclercqJohan GrootenB VANHAESEBROECKM VANDECRAEND VERCAMMENB DEPUYDTG DENECKER et al.

A1 Journal Article in CIRCULATORY SHOCK

1993

Two pathways of tumor necrosis factor signal transduction: in vitro and in vivo implications

Walter FiersRudi BeyaertPeter BrouckaertAnje CauwelsWim DeclercqDirk De ValckB EveraerdtVera GoossensJohan GrootenGuy Haegeman et al.

1992

Functional characterization of the human tumor necrosis factor receptor p75 in a transfected rat/mouse T cell hybridoma

Peter VandenabeeleWim DeclercqDominique VercammenMarc Van De CraenJohan GrootenHansruedi LoetscherManfred BrockhausWerner LesslauerWalter Fiers

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

1990

Development of a simple, sensitive and specific bioassay for interleukin-1 based on the proliferation of RPMI 1788 cells: comparison with other bioassays for IL-1

Peter VandenabeeleWim DeclercqClaude LibertWalter Fiers

A1 Journal Article in JOURNAL OF IMMUNOLOGICAL METHODS

Response of murine cell lines to an IL-1/IL-2 induced factor in a rat mouse T hybridoma (PC60) : differential induction of cytokines by human IL-1α and IL-1β and partial amino acid sequence of rat GM-CSF

Peter VandenabeeleYves GuisezWim DeclercqGuy BauwJoël VandekerckhoveWalter Fiers

A1 Journal Article in LYMPHOKINE RESEARCH

1987

Recombinant tumor necrosis factor can induce interleukin 2 receptor expression and cytolytic activity in a rat × mouse T cell hybrid

Geert PlaetinckWim DeclercqJan TavernierMarkus NabholzWalter Fiers

A1 Journal Article in EUROPEAN JOURNAL OF IMMUNOLOGY