Research Explorer

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Researcher

Wander Van Breedam

Awards & Distinctions

45 Results

2023

GlycoVHH : optimal sites for introducing N-glycans on the camelid VHH antibody scaffold and use for macrophage delivery

Loes van SchieWander Van BreedamCharlotte RoelsBert SchepensMartin FrankAhmadreza MehdipourBram LaukensWim NerinckxFrancis SantensSimon Devos et al.

A1 Journal Article in MABS

2022

GlyConnect-Ugi : site-selective, multi-component glycoprotein conjugations through GlycoDelete expressed glycans

Karel ThooftWander Van BreedamFrancis SantensElise WyseureSandrine VanmarckeSimon DevosNico CallewaertAnnemieke Madder

A1 Journal Article in ORGANIC & BIOMOLECULAR CHEMISTRY

GlycoVHH : introducing N-glycans on the camelid VHH antibody scaffold : optimal sites and use for macrophage delivery

Loes van SchieWander Van BreedamCharlotte RoelsBert SchepensMartin FrankAhmadreza MehdipourBram LaukensWim NerinckxFrancis SantensSimon Devos et al.

2021

An affinity-enhanced, broadly neutralizing heavy chain-only antibody protects against SARS-CoV-2 infection in animal models

Bert SchepensLoes van SchieWim NerinckxKenny RooseWander Van BreedamDaria FijalkowskaSimon DevosWannes WeytsSieglinde De CaeSandrine Vanmarcke et al.

A1 Journal Article in SCIENCE TRANSLATIONAL MEDICINE

GlyConnect : exploring glycan-based conjugation chemistries for GLycoDelete proteins

Karel ThooftAnnemieke MadderNico CallewaertWander Van Breedam

2020

Structural basis for potent neutralization of betacoronaviruses by single-domain camelid antibodies

Daniel WrappDorien De VliegerKizzmekia S. CorbettGretel M. TorresNianshuang WangWander Van BreedamKenny RooseLoes van SchieMarkus HoffmannStefan Poehlmann et al.

A1 Journal Article in CELL

Structural basis for potent neutralization of betacoronaviruses by single-domain camelid antibodies (vol 181, pg 1004, 2020)

Daniel WrappDorien De VliegerKizzmekia S. CorbettGretel M. TorresNianshuang WangWander Van BreedamKenny RooseLoes van SchieMarkus HoffmannStefan Pohlmann et al.

2017

Molecular cloning of porcine Siglec-3, Siglec-5 and Siglec-10, and identification of Siglec-10 as an alternative receptor for porcine reproductive and respiratory syndrome virus (PRRSV)

Jiexiong XieIsaura ChristiaensBo YangWander Van BreedamTingting CuiHans Nauwynck

A1 Journal Article in JOURNAL OF GENERAL VIROLOGY

2014

Bitter-sweet symphony: glycan–lectin interactions in virus biology

Wander Van BreedamStefan PöhlmannHerman FavoreelRaoul de GrootHans Nauwynck

A1 Journal Article in FEMS MICROBIOLOGY REVIEWS

Changing receptor use of PRRSV leads to different virological, immunological and clinical outcome: impact on diagnosis and control

Hans NauwynckIlias FrydasIsaura ChristiaensWander Van BreedamCaroline BonckaertIvan Trus

Detection of total and PRRSV-specific antibodies in oral fluids collected with different rope types from PRRSV-vaccinated and experimentally infected pigs

Inge DecorteWander Van BreedamYves Van der StedeHans NauwynckNick De ReggeAnn Brigitte Cay

A1 Journal Article in BMC VETERINARY RESEARCH

The intriguing game of porcine reproductive and respiratory syndrome virus with different macrophage subsets determines the virological and clinical outcome

Hans NauwynckIlias FrydasIvan TrusIsaura ChristiaensCaroline BonckaertWander Van Breedam

2013

Adaptable inactivated vaccine for combating Porcine Reproductive and Respiratory Syndrome Virus

Marc GeldhofHans NauwynckWander Van Breedam

Antibody response and maternal immunity upon boosting PRRSV-immune sows with experimental farm-specific and commercial PRRSV vaccines

Marc GeldhofWander Van BreedamEllen De JongAlfonso Lopez RodriguezUladzimir KarniychukMerijn VanheeJan Van DoorsselaereDominiek MaesHans Nauwynck

A1 Journal Article in VETERINARY MICROBIOLOGY

Porcine, murine and human sialoadhesin (Sn/Siglec-1/CD169): portals for porcine reproductive and respiratory syndrome virus entry into target cells

Wander Van BreedamMieke VerbeeckIsaura ChristiaensHanne Van GorpHans Nauwynck

A1 Journal Article in JOURNAL OF GENERAL VIROLOGY

The pathogenesis of porcine reproductive and respiratory syndrome (PRRS) is fully determined by the intriguing interplay of PRRSV with monocytic cells

Hans NauwynckUladzimir KarniychukMieke VerbeeckIsaura ChristiaensIvan TrusJun CaoIlias FrydasWander Van Breedam

2012

Comparison of the efficacy of autogenous inactivated Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) vaccines with that of commercial vaccines against homologous and heterologous challenges

Marc GeldhofMerijn VanheeWander Van BreedamJan Van DoorsselaereUladzimir KarniychukHans Nauwynck

A1 Journal Article in BMC VETERINARY RESEARCH

Demonstration of microchimerism in pregnant sows and effects of congenital PRRSV infection

Uladzimir KarniychukWander Van BreedamNadine Van RoyClaire Rogel-GaillardHans Nauwynck

A1 Journal Article in VETERINARY RESEARCH

Demonstration of microchimerism in pregnant sows and fetuses and putative microchimerism involvement in the pathogenesis of congenital PRRSV infection

Uladzimir KarniychukWander Van BreedamNadine Van RoyC Rogel-GaillardHans Nauwynck

Micro-dissecting the pathogenesis and immune response of PRRSV infection paves the way for more efficient PRRSV vaccines

Hans NauwynckHanne Van GorpMerijn VanheeUladzimir KarniychukMarc GeldhofJun CaoMieke VerbeeckWander Van Breedam

A1 Journal Article in TRANSBOUNDARY AND EMERGING DISEASES

The role of vaccines for PRRS control and PRRSV eradication

Hans NauwynckIvan TrusIsaura ChristiaensUladzimir KarniychukIlias FrydasJun CaoWander Van Breedam

2011

Better molecular insights in the pathogenesis of PRRSV infections and immune response show the way for more efficient PRRSV vaccines

Hans NauwynckWander Van BreedamHanne Van GorpUladzimir KarniychukMarc GeldhofA CaoMieke VerbeeckMerijn Vanhee

Characterization of antigenic regions in the porcine reproductive and respiratory syndrome virus by the use of peptide-specific serum antibodies

Merijn VanheeWander Van BreedamSarah CostersMarc GeldhofYtse NoppeHans Nauwynck

A1 Journal Article in VACCINE

Fetal and maternal cells are not present in the porcine myometrium and fetal placentas, respectively, at the last stage of gestation

Uladzimir KarniychukWander Van BreedamClaire Rogel-GaillardNadine Van RoyHans Nauwynck

Identification of non-neutralizing and neutralizing antigenic regions in PRRSV by the use of peptide-specific serum and antibodies

Merijn VanheeWander Van BreedamSarah CostersMarc GeldhofYtse NoppeHans Nauwynck

Interaction of the porcine reproductive and respiratory syndrome virus with the macrophage-specific lectin sialoadhesin

Wander Van BreedamHans NauwynckPeter Delputte

Porcine reproductive and respiratory syndrome virus (PRRSV) entry in its host cell, the macrophage

Hans NauwynckHanne Van GorpMieke VerbeeckIlias FrydasWander Van Breedam

Porcine reproductive and respiratory syndrome virus (PRRSV)-specific mAbs: supporting diagnostics and providing new insights into the antigenic properties of the virus

Wander Van BreedamSarah CostersMerijn VanheeCarl A GagnonIrene M Rodriguez-GomezMarc GeldhofMieke VerbeeckJan Van DoorsselaereUladzimir KarniychukHans Nauwynck

A1 Journal Article in VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY

Sibling and fetal microchimerism in healthy and porcine reproductive and respiratory syndrome virus infected dams

Uladzimir KarniychukWander Van BreedamClaire Rogel-GaillardNadine Van RoyHans Nauwynck

2010

A variable region in GP4 of European-type porcine reproductive and respiratory syndrome virus induces neutralizing antibodies against homologous but not heterologous virus strains

Merijn VanheeSarah CostersWander Van BreedamMarc GeldhofJan Van DoorsselaereHans Nauwynck

A1 Journal Article in VIRAL IMMUNOLOGY

GP4-specific neutralizing antibodies might be a driving force in PRRSV evolution

Sarah CostersMerijn VanheeWander Van BreedamJan Van DoorsselaereMarc GeldhofHans Nauwynck

A1 Journal Article in VIRUS RESEARCH

Genetic diversity of porcine reproductive and respiratory syndrome virus isolates in Flanders

Marc GeldhofJan Van DoorsselaereMerijn VanheeWander Van BreedamUladzimir KarniychukHans Nauwynck

Genetic diversity of porcine reproductive and respiratory syndrome virus isolates in Flanders

Marc GeldhofJan Van DoorsselaereMerijn VanheeWander Van BreedamUladzimir KarniychukHans Nauwynck

Identification of the CD163 protein domains involved in infection of the porcine reproductive and respiratory syndrome virus

Hanne Van GorpWander Van BreedamJan Van DoorsselaerePeter DelputteHans Nauwynck

Identification of the CD163 protein domains involved in infection of the porcine reproductive and respiratory syndrome virus

Hanne Van GorpWander Van BreedamJan Van DoorsselaerePeter DelputteHans Nauwynck

A1 Journal Article in JOURNAL OF VIROLOGY

Micro-dissecting the pathogenesis and immune response of PRRSV infection paves the way for more efficient PRRS vaccines

Hans NauwynckMerijn VanheeHanne Van GorpUladzimir KarniychukMarc GeldhofA CaoWander Van Breedam

Porcine reproductive and respiratory syndrome virus (PRRSV) entry in its host cell, the macrophage

Hans NauwynckWander Van Breedam

Porcine reproductive and respiratory syndrome virus entry into the porcine macrophage

Wander Van BreedamPeter DelputteHanne Van GorpGerald MisinzoNathalie VanderheijdenXiaoBo DuanHans Nauwynck

A1 Journal Article in JOURNAL OF GENERAL VIROLOGY

The M/GP(5) glycoprotein complex of porcine reproductive and respiratory syndrome virus binds the sialoadhesin receptor in a sialic acid-dependent manner

Wander Van BreedamHanne Van GorpJiquan Q ZhangPaul R CrockerPeter DelputteHans Nauwynck

A1 Journal Article in PLOS PATHOGENS

2009

The porcine reproductive and respiratory syndrome virus requires trafficking through CD163-positive early endosomes, but not late endosomes, for productive infection

Hanne Van GorpWander Van BreedamPeter DelputteHans Nauwynck

A1 Journal Article in ARCHIVES OF VIROLOGY

2008

Sialoadhesin and CD163 join forces during entry of the porcine reproductive and respiratory syndrome virus

Hanne Van GorpWander Van BreedamPeter DelputteHans Nauwynck

A1 Journal Article in JOURNAL OF GENERAL VIROLOGY

2007

IFN-α treatment enhances porcine Arterivirus infection of monocytes via upregulation of the porcine Arterivirus receptor sialoadhesin

Peter DelputteWander Van BreedamFilip BarbéKristien Van ReethHans Nauwynck

A1 Journal Article in JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Interferon alpha dependent enhancement of porcine reproductive and respiratory syndrome virus infection of monocytes

Peter DelputteWander Van BreedamMerijn VanheeFilip BarbéKristien Van ReethHans Nauwynck

Porcine arterivirus attachment to the macrophage-specific receptor sialoadhesin is dependent on the sialic acid-binding activity of the N-terminal immunoglobulin domain of sialoadhesin

Peter DelputteWander Van BreedamIris DelrueCornelia OetkePaul R CrockerHans Nauwynck

A1 Journal Article in JOURNAL OF VIROLOGY

Receptor mediated porcine arterivirus entry in macrophages

Peter DelputteHanne Van GorpWander Van BreedamGerald MisinzoIris DelrueHans Nauwynck