Research Explorer

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Researcher

Walther Fiers

Awards & Distinctions

649 Results

2018

M2e-tetramer-specific memory CD4 T cells are broadly protective against influenza infection

D. G. EliassonA. OmokanyeK. SchönU. A. WenzelV. BernasconiM. BemarkAnnasaheb KolpeKarim El BakkouriTine YsenbaertLei Deng et al.

A1 Journal Article in MUCOSAL IMMUNOLOGY

2017

Bispecific T cell engaging antibody constructs targeting a universally conserved part of the viral M2 ectodomain cure and prevent influenza A virus infection

Jochen PendzialekKenny RooseAnouk SmetBert SchepensPeter KuferTobias RaumPatrick A BaeuerleMarkus MuenzXavier SaelensWalther Fiers

A1 Journal Article in ANTIVIRAL RESEARCH

M2-based influenza vaccines : recent advances and clinical potential

Annasaheb KolpeBert SchepensWalther FiersXavier Saelens

A1 Journal Article in EXPERT REVIEW OF VACCINES

Oral delivery of Escherichia coli persistently infected with M2e-displaying bacteriophages partially protects against influenza A virus

Lei DengKenny RooseEmma JobRiet De RyckeEvelien Van HammeAmanda GonçalvesEef ParthoensLaetitia CiccheleroNiek SandersWalther Fiers et al.

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

2016

Crystal structure of the conserved amino terminus of the extracellular domain of matrix protein 2 of influenza A virus gripped by an antibody

Ki Joon ChoBert SchepensKristof MoonensLei DengWalther FiersHan RemautXavier Saelens

A1 Journal Article in JOURNAL OF VIROLOGY

Long-lasting cross-protection against influenza A by neuraminidase and M2e-based immunization strategies

Michael SchotsaertTine YsenbaertAnouk SmetBert SchepensDieter VanderschaegheSvetlana StegalkinaThorsten U VogelNico CallewaertWalther FiersXavier Saelens

A1 Journal Article in SCIENTIFIC REPORTS

2015

A GFP expressing influenza A virus to report in vivo tropism and protection by a matrix protein 2 ectodomain-specific monoclonal antibody

Sarah De BaetsJudith VerhelstSilvie Van den HoeckeAnouk SmetMichael SchotsaertEmma JobKenny RooseBert SchepensWalther FiersXavier Saelens

A1 Journal Article in PLOS ONE

Comparison of the antiviral activity of Mus spretus Mx1 and Mus musculus A2G Mx1 against influenza A viruses

Judith VerhelstJan SpitaelsCindy NürnbergerDorien De VliegerTine YsenbaertPeter StaeheliWalther FiersXavier Saelens

Functional comparison of Mx1 from two different mouse species reveals the involvement of loop L4 in the antiviral activity against influenza A viruses

Judith VerhelstJan SpitaelsCindy NurnbergerDorien De VliegerTine YsenbaertPeter StaeheliWalther FiersXavier Saelens

A1 Journal Article in JOURNAL OF VIROLOGY

M2e-based universal influenza A vaccines

Lei DengKi Joon ChoWalther FiersXavier Saelens

A2 Journal Article in VACCINES

Protection against influenza A virus challenge with M2e-displaying filamentous Escherichia coli phages

Lei DengLorena IbanezVeronique Van den BosscheKenny RooseSameh A YoussefAlain de BruinWalther FiersXavier Saelens

A1 Journal Article in PLOS ONE

Structure of the extracellular domain of matrix protein 2 of influenza A virus in complex with a protective monoclonal antibody

Ki Joon ChoBert SchepensJong Hyeon SeokSella KimKenny RooseJi-Hye LeeRodrigo GallardoEvelien Van HammeJoost SchymkowitzFrederic Rousseau et al.

A1 Journal Article in JOURNAL OF VIROLOGY

2014

Protection and mechanism of action of a novel human respiratory syncytial virus vaccine candidate based on the extracellular domain of small hydrophobic protein

Bert SchepensKoen SedeynLiesbeth Vande GinsteSarah De BaetsMichael SchotsaertKenny RooseLieselot HouspieMarc Van RanstBarbara GilbertNico van Rooijen et al.

A1 Journal Article in EMBO MOLECULAR MEDICINE

Single-domain antibodies targeting neuraminidase protect against an H5N1 influenza virus challenge

Miguel Lopez CardosoLorena IbanezSilvie Van den HoeckeSarah De BaetsAnouk SmetKenny RooseBert SchepensFrancis DescampsWalther FiersSerge Muyldermans et al.

A1 Journal Article in JOURNAL OF VIROLOGY

2013

Immunogenicity of live attenuated B. pertussis BPZE1 producing the universal influenza vaccine candidate M2e

Hana KammounXavier RouxDominique RazeAnne-Sophie DebrieMarina De FiletteTine YsenbaertNathalie MielcarekXavier SaelensWalther FiersCamille Locht

A1 Journal Article in PLOS ONE

M2e-displaying virus-like particles with associated RNA promote T helper 1 type adaptive immunity against influenza A

Lorena IbanezKenny RooseMarina De FiletteMichael SchotsaertJessica De SloovereStefan RoelsCharlotte PollardBert SchepensJohan GrootenWalther Fiers et al.

A1 Journal Article in PLOS ONE

Natural and long-lasting cellular immune responses against influenza in the M2e-immune host

Michael SchotsaertTine YsenbaertKristien NeytsLorena IbanezPieter BogaertBert SchepensBart LambrechtWalther FiersXavier Saelens

A1 Journal Article in MUCOSAL IMMUNOLOGY

Recombinant influenza virus carrying the respiratory syncytial virus (RSV) F85-93 CTL epitope reduces RSV replication in mice

Sarah De BaetsBert SchepensKoen SedeynMichael SchotsaertKenny RoosePieter BogaertWalther FiersXavier Saelens

A1 Journal Article in JOURNAL OF VIROLOGY

2012

Cutting edge approaches towards novel and cross-protective influenza vaccines

Kenny RooseMichael SchotsaertKarim El BakkouriBert SchepensWalther FiersXavier Saelens

Bookchapter in Development of novel vaccines : skills, knowledge and translational technologies

Interferon-inducible protein Mx1 inhibits influenza virus by interfering with functional viral ribonucleoprotein complex assembly

Judith VerhelstEef ParthoensBert SchepensWalther FiersXavier Saelens

A1 Journal Article in JOURNAL OF VIROLOGY

2011

A novel non-toxic combined CTA1-DD and ISCOMS adjuvant vector for effective mucosal immunization against influenza virus

Dubravka Grdic EliassonAnja HelgebyKarin SchonCaroline NygrenKarim El BakkouriWalther FiersXavier SaelensKarin Bengtsson LovgrenIda NystromNils Y Lycke

A1 Journal Article in VACCINE

Antiserum against the conserved nine amino acid N-terminal peptide of influenza A virus matrix protein 2 is not immunoprotective

Marina De FiletteTine YsenbaertKenny RooseMichael SchotsaertStefan RoelsEls GoossensBert SchepensWalther FiersXavier Saelens

A1 Journal Article in JOURNAL OF GENERAL VIROLOGY

Cytokine research in Belgium

Editorial material

Universal vaccine based on ectodomain of matrix protein 2 of Influenza A: Fc receptors and alveolar macrophages mediate protection

Karim El BakkouriFrancis DescampsMarina De FiletteAnouk SmetEls FestjensAshley BirkettNico Van RooijenSjef VerbeekWalther FiersXavier Saelens

A1 Journal Article in JOURNAL OF IMMUNOLOGY

2010

Controlling influenza by cytotoxic T-cells : calling for help from destroyers

Michael SchotsaertLorena IbanezWalther FiersXavier Saelens

A1 Journal Article in JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

2009

Cloning and expression of human interferon-beta: from bc to ac

A4 Journal Article in VERHANDELINGEN VAN DE KONINKLIJKE ACADEMIE VOOR GENEESKUNDE VAN BELGIË

M2e-based universal influenza A vaccine

Walther FiersMarina De FiletteKarim El BakkouriBert SchepensKenny RooseMichael SchotsaertA BirkettXavier Saelens

A1 Journal Article in VACCINE

PANDEMIC PREPAREDNESS: TOWARD A UNIVERSAL INFLUENZA VACCINE

Kenny RooseWalther FiersXavier Saelens

A1 Journal Article in DRUG NEWS & PERSPECTIVES

Universal M2 ectodomain-based influenza A vaccines: preclinical and clinical developments

Michael SchotsaertMarina De FiletteWalther FiersXavier Saelens

A1 Journal Article in EXPERT REVIEW OF VACCINES

2008

An influenza A vaccine based on tetrameric ectodomain of matrix protein 2

Marina De FiletteWouter MartensKenny RooseTom DerooFrederik VervalleMostafa BentahirJoël VandekerckhoveWalther FiersXavier Saelens

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

CTA1-M2e-DD: A novel mucosal adjuvant targeted influenza vaccine

DG ELIASSONKarim El BakkouriK SCHOENA RAMNEEls FestjensB LOWENADLERWalther FiersXavier SaelensN LYCKE

A1 Journal Article in VACCINE

Universal influenza A M2e-HBc vaccine protects against disease even in the presence of pre-existing anti-HBc antibodies

Marina De FiletteWouter MartensAnouk SmetMichael SchotsaertAshley BirkettPatricia Londoño-ArcilaWalther FiersXavier Saelens

A1 Journal Article in Vaccine

2006

A universal vaccine against influenza

A3 Journal Article in Bulletin et mémoires de l'Académie royale de médecine de Belgique

Improved design and intranasal delivery of an M2e-based human influenza A vaccine

Marina De FiletteWalther FiersWouter MartensA BIRKETTA RAMNEB LOWENADLERN LYCKEWM JOUXavier Saelens

A1 Journal Article in VACCINE

Improved periplasmic production of biologically active murine interleukin-2 in Escherichia coli through a single amino acid change at the cleavage site

Johan RobbensW DE COENWalther FiersErik Remaut

A1 Journal Article in PROCESS BIOCHEMISTRY

The universal influenza vaccine M2e-HBc administered intranasally in combination with the adjuvant CTA1-DD provides complete protection

Marina De FiletteA RAMNEA BIRKETTN LYCKEB LOWENADLERWM JOUXavier SaelensWalther Fiers

A1 Journal Article in VACCINE

2005

Universal influenza A vaccine: Optimization of M2-based constructs

Marina De FiletteWM JOUA BIRKETTK LYONSB SCHULTZA TONKYROS RESCHWalther Fiers

A1 Journal Article in VIROLOGY

2004

A "universal" human influenza A vaccine

Walther FiersMarina De FiletteA BIRKETTSabine NeirynckWM JOU

A1 Journal Article in VIRUS RESEARCH

Tumor necrosis factor-alpha augmented tumor response in B16BL6 melanoma-bearing mice treated with stealth liposomal doxorubicin (DOXIL (R)) correlates with altered DOXIL (R) pharmacokinetics

Peter BrouckaertN TAKAHASHIST VAN TIELJeroen HostensAMM EGGERMONTALB SEYNHAEVEWalther FiersTLM TEN HAGEN

A1 Journal Article in INTERNATIONAL JOURNAL OF CANCER

2002

Bioavailability of recombinant tumor necrosis factor determines its lethality in mice.

Paul AmelootNozomi TakahashiBart EveraerdtJeroen HostensHP EUGSTERWalther FiersPeter Brouckaert

A1 Journal Article in EUROPEAN JOURNAL OF IMMUNOLOGY

Characterization of the interaction between murine tumour necrosis factor and monoclonal antibodies.

Paul AmelootWalther FiersWA BUURMANP DE BAETSELIERPeter Brouckaert

A1 Journal Article in CYTOKINE

Spontaneous and oncogene-mediated acquisition of the invasive phenotype by cells in culture.

Marcus MareelP COOPMANC DRAGONETTIWalther FiersJ GAOL MESSIAENFrans Van Roy

2001

Death receptor-induced apoptotic and necrotic cell death: differential role of caspases and mitochondria.

Geertrui DeneckerD VERCAMMENMargino SteemansTom Vanden BergheGreet BrouckaertGeert van LooB ZHIVOTOVSKYWalther FiersJohan GrootenWim Declercq et al.

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Expression in Escherichia coli of the death domain of the human p55 tumor necrosis factor receptor.

Gert De WildeNico MertensElke BooneB DE VREESEJozef Van BeeumenWalther FiersGuy Haegeman

A1 Journal Article in PROTEIN EXPRESSION AND PURIFICATION

Heterotrimers formed by tumor necrosis factors of different species or muteins.

Paul AmelootWim DeclercqWalther FiersPeter VandenabeelePeter Brouckaert

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of tumor necrosis factor (TNF) amino acids crucial for binding to the murine p75 TNF receptor and construction of receptor-selective mutants.

Paul AmelootWalther FiersPieter De BleserCF WAREPeter VandenabeelePeter Brouckaert

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Kanker: wat brengt de toekomst?

A4 Journal Article in VERHANDELINGEN VAN DE KONINKLIJKE ACADEMIE VOOR GENEESKUNDE VAN BELGIË

Soluble recombinant influenza vaccines

Walther FiersSabine NeirynckTom DerooXavier SaelensWilly Min Jou

A1 Journal Article in PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES

2000

Cloning and expression of cytokine genes

Wim DeclercqMarc LoggheWalther FiersRoland Contreras

Bookchapter in Cytokine molecular biology : a practical approach

Fab chains as an efficient heterodimerization scaffold for the production of recombinant bispecific and trispecific antibody derivatives.

Reinhilde SchoonjansAn WillemsSteve SchoonoogheWalther FiersJohan GrootenNico Mertens

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Phosphatidyl serine exposure during apoptosis precedes release of cytochrome c and decrease in mitochondrial transmembrane potential.

Geertrui DeneckerHans DoomsGeert van LooD VERCAMMENJohan GrootenWalther FiersWim DeclercqPeter Vandenabeele

A1 Journal Article in FEBS LETTERS

Protection against TNF-induced lethal shock by soluble guanylate cyclase inhibition requires functional inducible nitric oxide synthase.

Anje CauwelsWim Van MolleB JANSSENBart EveraerdtP HUANGWalther FiersPeter Brouckaert

A1 Journal Article in IMMUNITY

Role of reactive oxygen species in tumor necrosis factor toxicity

Vera GoossensKurt De VosDominique VercammenMargino SteemansKatia VancompernolleWalther FiersPeter VandenabeeleJohan Grooten

Bookchapter in Antioxidant and redox regulation of genes

Structure/function analysis of p55 tumor necrosis factor receptor and Fas-associated death domain : effect on necrosis in L929sA cells.

Elke BooneTom Vanden BergheGeert van LooGert De WildeN DE WAELD VERCAMMENWalther FiersGuy HaegemanPeter Vandenabeele

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Treatment of murine colitis by Lactococcus lactis secreting interleukin-10.

Lothar SteidlerWolfgang HansLieven SchotteSabine NeirynckF OBERMEIERW FALKWalther FiersErik Remaut

A1 Journal Article in SCIENCE

Tumor necrosis factor-induced microtubule stabilization mediated by hyperphosphorylated oncoprotein 18 promotes cell death.

K VANCOMPERNOLLETom BoonefaesM MANNWalther FiersJohan Grooten

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

1999

A universal influenza A vaccine based on the extracellular domain of the M2 protein.

Sabine NeirynckTom DerooXavier SaelensP VANLANDSCHOOTWilly Min JouWalther Fiers

A1 Journal Article in NATURE MEDICINE

An advanced vector system for high-level recombinant gene expression in Escherichia coli

Nico MertensWalther FiersErik Remaut

Bookchapter in Biotechnology international II

GAL4 is a substrate for caspases : implications for two-hybrid screening and other GAL4-based assays

Wim Van CriekingeSigrid CornelisMarc Van De CraenPeter VandenabeeleWalther FiersRudi Beyaert

A2 Journal Article in MOLECULAR CELL BIOLOGY RESEARCH COMMUNICATIONS

Identification of a locus on distal mouse chromosome 12 that controls resistance to tumor necrosis factor-induced lethal shock.

Claude LibertBen WielockxGL HAMMONDPeter BrouckaertWalther FiersRW ELLIOTT

A1 Journal Article in GENOMICS

Identification of caspases that cleave presenilin-1 and presenilin-2 - Five presenilin-1 (PS1) mutations do not alter the sensitivity of PS1 to caspases.

Marc Van De CraenC DE JONGHEI VAN DEN BRANDEWim DeclercqG VAN GASSENWim Van CriekingeI VANDERHOEVENWalther FiersC VAN BROECKHOVENL HENDRIKS et al.

A1 Journal Article in FEBS LETTERS

Inhibition of Tumor Necrosis Factor-induced necrotic cell death by the zinc finger protein A20.

Karen HeyninckGeertrui DeneckerDirk De ValckWalther FiersRudi Beyaert

A1 Journal Article in ANTICANCER RESEARCH

More than one way to die: apoptosis, necrosis and reactive oxygen damage.

Walther FiersRudi BeyaertWim DeclercqPeter Vandenabeele

A1 Journal Article in ONCOGENE

Multiple signal transduction pathways regulate TNF-induced actin reorganization in macrophages: Inhibition of Cdc42-mediated filopodium formation by TNF.

M PEPPELENBOSCHElke BooneGE JONESSJH VAN DEVENTERGuy HaegemanWalther FiersJohan GrootenAJ RIDLEY

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Protection of mice against a lethal influenza virus challenge after immunization with yeast-derived secreted influenza virus hemagglutinin.

Xavier SaelensP VANLANDSCHOOTWim MartinetMarleen MarasSabine NeirynckRoland ContrerasWalther FiersWilly Min Jou

A1 Journal Article in EUROPEAN JOURNAL OF BIOCHEMISTRY

Proteolytic cleavage of beta-catenin by caspases: an in vitro analysis.

Marc Van De CraenGeert BerxI VAN DEN BRANDEWalther FiersWim DeclercqPeter Vandenabeele

A1 Journal Article in FEBS LETTERS

Redox regulation of TNF signaling.

Vera GoossensKurt De VosD VERCAMMENMargino SteemansK VANCOMPERNOLLEWalther FiersPeter VandenabeeleJohan Grooten

A1 Journal Article in BIOFACTORS

TNF-signalisatie leidend tot geninductie en celdood in de muis fibrosarcoma cellijn L929 : rol van de 55 kDa TNF-receptor

Veronique VandevoordeGuy HaegemanWalther Fiers

The proteolytic procaspase activation network: an in vitro analysis.

Marc Van De CraenWim DeclercqI VAN DEN BRANDEWalther FiersPeter Vandenabeele

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

The role of complement activation in tumour necrosis factor-induced lethal hepatitis.

Claude LibertBen WielockxB GRIJALBAWim Van MolleE KREMMERHR COLTENWalther FiersPeter Brouckaert

A1 Journal Article in CYTOKINE

The structure of mouse tumour-necrosis factor at 1.4 angstrom resolution: towards modulation of its selectivity and trimerization.

KJ BAEYENSHL DE BONDTA RAEYMAEKERSWalther FiersCJ DE RANTER

A1 Journal Article in ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

The zinc finger protein A20 inhibits TNF-induced NF-kappa B-dependent gene expression by interfering with an RIP- or TRAF2-mediated transactivation signal and directly binds to a novel NF-kappa B-inhibiting protein ABIN.

Karen HeyninckDirk De ValckWim Vanden BergheWim Van CriekingeRoland ContrerasWalther FiersGuy HaegemanRudi Beyaert

A1 Journal Article in JOURNAL OF CELL BIOLOGY

The zinc finger protein A20 interacts with a novel anti-apoptotic protein which is cleaved by specific caspases.

Dirk De ValckDY JINKaren HeyninckMarc Van De CraenRoland ContrerasWalther FiersKT JEANGRudi Beyaert

A1 Journal Article in ONCOGENE

1998

An antibody which binds to the membrane-proximal end of influenza virus haemagglutinin (H3 subtype) inhibits the low-pH-induced conformational change and cell-cell fusion but does not neutralize virus.

Peter VanlandschootE BEIRNAERTB BARREREL CALDERB MILLARS WHARTONWilly Min JouWalther Fiers

A1 Journal Article in JOURNAL OF GENERAL VIROLOGY

Atractyloside-induced release of cathepsin B, a protease with caspase-processing activity.

Katia VancompernolleF VAN HERREWEGHEGwenda PynaertMarc Van De CraenKurt De VosN TOTTYA STERLINGWalther FiersPeter VandenabeeleJohan Grooten

A1 Journal Article in FEBS LETTERS

Autocrine tumor necrosis factor (TNF) and lymphotoxin (LT) alpha differentially modulate cellular sensitivity to TNF/LT-alpha cytotoxicity in L929 cells.

Els DecosterSigrid CornelisB VANHAESEBROECKWalther Fiers

A1 Journal Article in JOURNAL OF CELL BIOLOGY

Cathepsin B-mediated activation of the proinflammatory caspase-11

Peter SchotteWim Van CriekingeMarc Van De CraenGeert van LooMarjory DesmedtJohan GrootenMaria CornelissenLeo De RidderJoël VandekerckhoveWalther Fiers et al.

A1 Journal Article in BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cloning and characterization of murine caspases

Marc Van De CraenP. VandenabeeleWalther FiersF. Van Roy

Cloning and expression of a fused gene encoding TNFRI death domain and chloramphenicol acetyltransferase.

LZ LINCB LISY ZHAOG DE WILDEGuy HaegemanWalther Fiers

A1 Journal Article in ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Cooperation of both TNF receptors in inducing apoptosis: Involvement of the TNF receptor-associated factor binding domain of the TNF receptor 75.

Wim DeclercqGeertrui DeneckerWalther FiersPeter Vandenabeele

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Cross-talk between steroids and NF-kappa B: what language?

A DUMONTSP HEHNERML SCHMITZJA GUSTAFSSONJ LIDENS OKRETPT VAN DER SAAGS WISSINKB VAN DER BURGP HERRLICH et al.

A1 Journal Article in TRENDS IN BIOCHEMICAL SCIENCES

Differential activation of phospholipases during necrosis or apoptosis: A comparative study using tumor necrosis factor and anti-Fas antibodies.

Dirk De ValckDominique VercammenWalther FiersRudi Beyaert

A1 Journal Article in JOURNAL OF CELLULAR BIOCHEMISTRY

Differentiation of EL4 lymphoma cells by tumoral environment is associated with inappropriate expression of the large chondroitin sulfate proteoglycan PG-M and the tumor-associated antigen HTgp-175.

Pieter RottiersT VERFAILLIERoland ContrerasH REVETSMarjory DesmedtH DOOMSWalther FiersJohan Grooten

A1 Journal Article in INTERNATIONAL JOURNAL OF CANCER

Dual signaling of the Fas receptor: Initiation of both apoptotic and necrotic cell death pathways.

Dominique VercammenGreet BrouckaertGeertrui DeneckerMarc Van De CraenWim DeclercqWalther FiersPeter Vandenabeele

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

Efficient secretion of biologically active recombinant OB protein (leptin) in Escherichia coli, purification from the periplasm and characterization.

Yves GuisezI FACHELA CAMPFIELDFJ SMITHA FARIDG PLAETINCKJ VAN DER HEYDENJan TavernierWalther FiersP BURN et al.

A1 Journal Article in PROTEIN EXPRESSION AND PURIFICATION

Engineering of the carbohydrate moiety of fungal proteins to a mammalian type

Marleen MarasA De BruynJ SchramlP HerdewijnKathleen PiensMarc ClaeyssensJ UusitaloM PenttilaWalther FiersRoland Contreras

Bookchapter in Carbohydrates from Trichoderma reesei and other microorganisms : structures, biochemistry, genetics and applications

Evaluation of recombinant A/Victoria/3/75 (H3N2) influenza neuraminidase mutants as potential broad-spectrum subunit vaccines against influenza A.

Wim MartinetTom DerooXavier SaelensEls BeirnaertPeter VanlandschootRoland ContrerasWalther FiersWilly Min Jou

A1 Journal Article in ARCHIVES OF VIROLOGY

Functional display of a heterologous protein on the surface of Lactococcus lactis by means of the cell wall anchor of Staphylococcus aureus protein A

Lothar SteidlerJasmine ViaeneWalther FiersErik Remaut

A1 Journal Article in APPLIED AND ENVIRONMENTAL MICROBIOLOGY

High-level constitutive expression of alpha(1)-acid glycoprotein and lack of protection against tumor necrosis factor-induced lethal shock in transgenic mice.

Claude LibertTino HochepiedFG BERGERH BAUMANNWalther FiersPeter Brouckaert

A1 Journal Article in TRANSGENIC RESEARCH

Identification of a new caspase homologue: caspase-14.

Marc Van De CraenGeert van LooS PYPEWim Van CriekingeI VAN DEN BRANDEFrancis MolemansWalther FiersWim DeclercqPeter Vandenabeele

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Induction of unresponsiveness to tumor necrosis factor (TNF) after autocrine TNF expression requires TNF membrane retention.

Els DecosterB VANHAESEBROECKElke BooneS PLAISANCEKurt De VosGuy HaegemanJohan GrootenWalther Fiers

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of caspases increases the sensitivity of L929 cells to necrosis mediated by tumor necrosis factor.

Dominique VercammenRudi BeyaertGeertrui DeneckerVera GoossensGeert van LooWim DeclercqJohan GrootenWalther FiersPeter Vandenabeele

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

Karakterisering van caspasen in een '2 en 3-hybrid'-systeem

Wim Van CriekingeRudi BeyaertWalther FiersRoland Contreras

Macrophages induce cellular immunity by activating Th1 cell responses and suppressing Th2 cell responses.

Marjory DesmedtP ROTTIERSH DOOMSWalther FiersJohan Grooten

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Molecular cloning and identification of murine caspase-8.

M VAN DE CRAENGeert van LooWim DeclercqP SCHOTTEI VAN DEN BRANDES MANDRUZZATOP VAN DER BRUGGENWalther FiersPeter Vandenabeele

A1 Journal Article in JOURNAL OF MOLECULAR BIOLOGY

Quiescence-inducing and antiapoptotic activities of IL-15 enhance secondary CD4(+) T cell responsiveness to antigen.

B DOOMSMarjory DesmedtS VANCAENEGHEMPieter RottiersVera GoossensWalther FiersJohan Grooten

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Regulation of microsomal triglyceride transfer protein mRNA expression by endotoxin and cytokines.

M NAVASADA GORDONN HARIHARANH JAMILJK SHIGENAGAA MOSERWalther FiersA POLLOCKC GRUNFELDKR FEINGOLD

A1 Journal Article in JOURNAL OF LIPID RESEARCH

Studie van TNF toxiciteit in muismodellen

Bart EveraerdtPeter BrouckaertWalther Fiers

TRAF2 plays a dual role in NF-kappa B-dependent gene activation by mediating the TNF-induced activation of p38 MAPK and I kappa B kinase pathways.

Isabelle CarpentierWim DeclercqNL MALININD WALLACHWalther FiersRudi Beyaert

A1 Journal Article in FEBS LETTERS

The 55-kDa tumor necrosis factor receptor induces clustering of mitochondria through its membrane-proximal region.

Kurt De VosVera GoossensElke BooneDominique VercammenK VANCOMPERNOLLEPeter VandenabeeleGuy HaegemanWalther FiersJohan Grooten

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Tumor necrosis factor and lymphotoxin

Rudi BeyaertWalther Fiers

Bookchapter in Cytokines

Use of the yeast three-hybrid system as a tool to study caspases.

Wim Van CriekingeMarjan Van GurpEls DecosterPeter SchotteMarc Van De CraenWalther FiersPeter VandenabeeleRudi Beyaert

A1 Journal Article in ANALYTICAL BIOCHEMISTRY

p38 and extracellular signal-regulated kinase mitogen-activated protein kinase pathways are required for nuclear factor kappa B p65 transactivation mediated by tumor necrosis factor.

Wim Vanden BergheS PLAISANCEElke BooneKarolien De BosscherML SCHMITZWalther FiersGuy Haegeman

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

pH-dependent aggregation and secretion of soluble monomeric influenza hemagglutinin.

Peter VanlandschootEls BeirnaertJohan GrootenWilly Min JouWalther Fiers

A1 Journal Article in ARCHIVES OF VIROLOGY

1997

A radioactive assay for sialyltransferase activity using 96-well multiscreen filtration plates.

Wouter LaroyMarleen MarasWalther FiersRoland Contreras

A1 Journal Article in ANALYTICAL BIOCHEMISTRY

A20 inhibits NF-kappa B activation independently of binding to 14-3-3 proteins.

Dirk De ValckKaren HeyninckWim Van CriekingePeter VandenabeeleWalther FiersRudi Beyaert

A1 Journal Article in BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cell death induction by receptors of the TNF family: Towards a molecular understanding.

D WALLACHM BOLDINE VARFOLOMEEVRudi BeyaertPeter VandenabeeleWalther Fiers

A1 Journal Article in FEBS LETTERS

Characterization of seven murine caspase family members

Marc Van de CraenPeter VandenabeeleWim DeclercqIlse Van den BrandeGeert van LooFrancis MolemansPeter SchotteWim Van CriekingeRudi BeyaertWalther Fiers

A1 Journal Article in FEBS LETTERS

Cleavage of PITSLRE kinases by ICE/CASP-1 and CPP32/CASP-3 during apoptosis induced by tumor necrosis factor.

Rudi BeyaertVJ KIDDSigrid CornelisM VANDECRAENGeertrui DeneckerJM LAHTIR GURURAJANPeter VandenabeeleWalther Fiers

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Cleavage of caspase family members by granzyme B: A comparative study in vitro.

M VANDECRAENI VANDENBRANDEWim DeclercqM IRMLERRudi BeyaertJ TSCHOPPWalther FiersPeter Vandenabeele

A1 Journal Article in EUROPEAN JOURNAL OF IMMUNOLOGY

Crucial role of tumor necrosis factor (TNF) receptor 2 and membrane-bound TNF in experimental cerebral malaria.

R LUCASP JUILLARDEls DecosterM REDARDD BURGERY DONATIC GIROUDC MONSOHINARDT DEKESELWA BUURMAN et al.

A1 Journal Article in EUROPEAN JOURNAL OF IMMUNOLOGY

Crystallization and preliminary X-ray studies of mouse tumor necrosis factor.

KJ BAEYENSHL DEBONDTA RAEYMAEKERSCJ DERANTERWalther Fiers

A1 Journal Article in ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

De 75 kDa TNF-receptor: rol in TNF-afhankelijke signalisatie leidend naar geninductie en apoptose

Wim DeclercqWalther FiersR. Contreras

Differential involvement of caspases in apoptosis of myeloid leukemic cells induced by chemotherapy versus growth factor withdrawal.

RMY BARGER WILLEMZEPeter VandenabeeleWalther FiersRudi Beyaert

A1 Journal Article in FEBS LETTERS

Differential role of calcium in tumour necrosis factor-mediated apoptosis and secretion of granulocyte-macrophage colony-stimulating factor in a T cell hybridoma.

Geertrui DeneckerPeter VandenabeeleJohan GrootenLC PENNINGWim DeclercqRudi BeyaertWA BUURMANWalther Fiers

A1 Journal Article in CYTOKINE

Glucocorticoid-mediated repression of nuclear factor-κB-dependent transcription involves direct interference with transactivation

Karolien De BosscherM Lienhard SchmitzWim Vanden BergheStéphane PlaisanceWalther FiersGuy Haegeman

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In vitro conversion of the carbohydrate moiety of fungal glycoproteins to mammalian-type oligosaccharides - Evidence for N-acetylglucosaminyltransferase-I-accepting glycans from Trichoderma reesei.

Marleen MarasXavier SaelensWouter LaroyK PIENSMarc ClaeyssensWalther FiersRoland Contreras

A1 Journal Article in EUROPEAN JOURNAL OF BIOCHEMISTRY

In vitro conversion of the conversion of the carbohydrate moiety of fungal glycoproteins to mammalian-type oligosaccharides. Evidence for iV-acetylglucosaminyltransferase-I-accepting glycans from Trichoderma reesei

M MARASX SAELENSWouter LaroyKathleen PiensMarc ClaeyssensWalther FiersRoland Contreras

A2 Journal Article in Eur. J. Biochem., 2 45, 617-625

Induced expression of trimerized intracellular domains of the human tumor necrosis factor (TNF) p55 receptor elicits TNF effects.

Veronique VandevoordeGuy HaegemanWalther Fiers

A1 Journal Article in JOURNAL OF CELL BIOLOGY

Modulatie van TNF-responsiviteit door autocriene TNF-produktie

Els DecosterWalther FiersR. Contreras

Protection of mice against a lethal influenza challenge by immunization with yeast-derived recombinant influenza neuraminidase.

Wim MartinetXavier SaelensTom DerooSabine NeirynckRoland ContrerasWilly Min JouWalther Fiers

A1 Journal Article in EUROPEAN JOURNAL OF BIOCHEMISTRY

Recombination signal sequence binding protein J kappa is constitutively bound to the NF-kappa B site of the interleukin-6 promoter and acts as a negative regulatory factor.

S PLAISANCEW VANDENBERGHEElke BooneWalther FiersGuy Haegeman

A1 Journal Article in MOLECULAR AND CELLULAR BIOLOGY

Resistance to tumor necrosis factor (TNF) cytotoxicity by autocrine TNF production is independent of intracellular signaling pathways.

Els DecosterVeronique VandevoordeRudi BeyaertGuy HaegemanWalther Fiers

A1 Journal Article in FEBS LETTERS

Structural characterization of N-linked oligosaccharides from cellobiohydrolase I secreted by the filamentous fungus Trichoderma reesei RUTC30

Marleen MarasAndré De BruynJ SchramlPiet HerdewijnMarc ClaeyssensWalther FiersRoland Contreras

A1 Journal Article in EUROPEAN JOURNAL OF BIOCHEMISTRY

Tumour necrosis factor-induced necrosis versus anti-Fas-induced apoptosis in L929 cells.

Dominique VercammenPeter VandenabeeleRudi BeyaertWim DeclercqWalther Fiers

A1 Journal Article in CYTOKINE

Tumour necrosis factor: intracellular mechanism of action

Walther FiersRudi BeyaertElke BooneWim DeclercqEls DecosterDirk De ValckVera GoossensJohan GrootenGuy HaegemanKaren Heyninck et al.

Bookchapter in HIV and cytokines

al-Acid glycoprotein and al-antitrypsin inhibit TNF-induced but not anti-Fas-induced apoptosis of hepatocytes in mice

Wim Van MolleClaude LibertWalther FiersPeter Brouckaert

A2 Journal Article in J. Immunol. 159, 3555-3564, 1997

alpha(1)-acid glycoprotein and alpha(1)-antitrypsin inhibit TNF-induced but not anti-Fas-induced apoptosis of hepatocytes in mice.

W VANMOLLEClaude LibertWalther FiersPeter Brouckaert

A1 Journal Article in JOURNAL OF IMMUNOLOGY

1996

A20, an inhibitor of cell death, self-associates by its zinc finger domain.

Dirk De ValckKaren HeyninckWim Van CriekingeRoland ContrerasRudi BeyaertWalther Fiers

A1 Journal Article in FEBS LETTERS

Abnormal glutathione and sulfate levels after interleukin 6 treatment and in tumor-induced cachexia.

V HACKA GROSSR KINSCHERFM BOCKSTETTEWalther FiersG BERKEW DROGE

A1 Journal Article in FASEB JOURNAL

ESM-1 is a novel human endothelial cell-specific molecule expressed in lung and regulated by cytokines.

P LASSALLES MOLETA JANINJ VANDERHEYDENJan TavernierWalther FiersR DEVOSAB TONNEL

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Expression of human and murine interleukins in Lactococcus lactis

Lothar SteidlerWalther FiersErik Remaut

Bookchapter in Lactic Acid Bacteria: Current Advances in Metabolism, Genetics and Applications

Functional characterization of the prodomain of interleukin-1 beta-converting enzyme.

Wim Van CriekingeRudi BeyaertM VANDECRAENPeter VandenabeelePeter SchotteD DEVALCKWalther Fiers

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Genomische analyse en heterologe genexpressie in gisten : Saccharomyces cerevisiae en Pichia pastoris

Marc LoggheWalther Fiers

Het menselijke E-cadherine gen : moleculaire karakterisering en analyse van genetische defecten in menselijke tumoren

Geert BerxWalther FiersF. Van Roy

Increased stability of phage T7g10 mRNA is mediated by either a 5'- or a 3'-terminal stem-loop structure.

Nico MertensErik RemautWalther Fiers

A1 Journal Article in BIOLOGICAL CHEMISTRY

Inhibition of and sensitization to the lethal effects of tumor necrosis factor

Peter BrouckaertClaude LibertAnje CauwelsBart EveraerdtWim Van MollePaul AmelootYannick GansemansBernardo GrijalbaNozomi TakahashiMarie-José Truong et al.

A1 Journal Article in JOURNAL OF INFLAMMATION

Karakterisering van recombinant hemagglutinine en isolatie van kruisreagerende monoclonale antilichamen

Peter VanlandschootWalther Fiers

Methylprednisolone differentially regulates IL-10 and tumour necrosis factor (TNF) production during murine endotoxaemia.

A MARCHANTZ AMRAOUIC GUEYDANC BRUYNSO LEMOINEPeter VandenabeeleWalther FiersWA BUURMANM GOLDMAN

A1 Journal Article in CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Molecular and immunological characterization of soluble aggregated A/Victoria/3/75 (H3N2) influenza haemagglutinin expressed in insect cells.

Peter VanlandschootEls BeirnaertSabine NeirynckXavier SaelensWilly Min JouWalther Fiers

A1 Journal Article in ARCHIVES OF VIROLOGY

Murine IL-12 is involved in Calmette-Guerin Bacillus-induced sensitization and is by itself sufficient to sensitize mice to the lethal effects of human TNF.

Anje CauwelsWalther FiersPeter Brouckaert

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Onderzoek naar de genetische basis verantwoordelijk voor resistentie van cellen tegen het cytotoxisch effect van TNF

Anne LenaertsWalther Fiers

Optimization of heterologous gene expression in Escherichia coli

Nico MertensWalther Fiers

Platelet-activating factor is a mediator in tumor necrosis factor galactosamine-induced lethality.

Claude LibertWim Van MollePeter BrouckaertWalther Fiers

A1 Journal Article in JOURNAL OF INFLAMMATION

Recombinant neuraminidase vaccine protects against lethal influenza.

Tom DerooWilly Min JouWalther Fiers

A1 Journal Article in VACCINE

Rol van mitochondriën in het cytotoxisch aktiemechanisme van tumor nekrosis faktor in tumorcellen

Vera GoossensWalther FiersJ. Grooten

Synergistic induction of endothelial tissue factor by tumor necrosis factor and vascular endothelial growth factor: Functional analysis of the tumor necrosis factor receptors.

M CLAUSSM GRELLC FANGMANNWalther FiersP SCHEURICHW RISAU

A1 Journal Article in FEBS LETTERS

TNF receptor p55 plays a major role in centrally mediated increases of serum IL-6 and corticosterone after intracerebroventricular injection of TNF.

F BENIGNIR FAGGIONIM SIRONIG FANTUZZIPeter VandenabeeleNozomi TakahashiS SACCOWalther FiersWA BUURMANP GHEZZI

A1 Journal Article in JOURNAL OF IMMUNOLOGY

TNF-induced intracellular signaling leading to gene induction or to cytotoxicity by necrosis or by apoptosis.

Walther FiersRudi BeyaertElke BooneSigrid CornelisWim DeclercqEls DecosterGeertrui DeneckerBart DepuydtDirk De ValckG DEWILDE et al.

A1 Journal Article in JOURNAL OF INFLAMMATION

The expression of the Photinus pyralis luciferase gene in Staphylococcus aureus Cowan I allows the development of a live amplifiable tool for immunodetection.

Lothar SteidlerW YUWalther FiersErik Remaut

A1 Journal Article in APPLIED AND ENVIRONMENTAL MICROBIOLOGY

The oxidative metabolism of glutamine - A modulator of reactive oxygen intermediate-mediated cytotoxicity of tumor necrosis factor in L929 fibrosarcoma cells.

Vera GoossensJohan GrootenWalther Fiers

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

The p38/RK mitogen-activated protein kinase pathway regulates interleukin-6 synthesis in response to tumour necrosis factor.

Rudi BeyaertA CUENDAW VANDENBERGHES PLAISANCEJC LEEGuy HaegemanP COHENWalther Fiers

A1 Journal Article in EMBO JOURNAL

Tumor necrosis factor and the systemic inflammatory response syndrome.

Peter BrouckaertWalther Fiers

A1 Journal Article in CURRENT TOPICS IN MICROBIOLOGY AND IMMUNOLOGY

Tumour growth results in changes in placental amino acid transport in the rat: A tumour necrosis factor alpha-mediated effect.

N CARBOFJ LOPEZSORIANOWalther FiersJM ARGILES

A1 Journal Article in BIOCHEMICAL JOURNAL

al-Antitrypsin inhibits the lethal response to TNF in mice

Claude LibertWim Van MollePeter BrouckaertWalther Fiers

A2 Journal Article in J. Immunol. 157, 5126-5129, 1996

alpha(1)-antitrypsin inhibits the lethal response to TNF in mice.

Claude LibertWim Van MollePeter BrouckaertWalther Fiers

A1 Journal Article in JOURNAL OF IMMUNOLOGY

1995

2 TUMOR-NECROSIS-FACTOR RECEPTORS - STRUCTURE AND FUNCTION.

Peter VandenabeeleWim DeclercqRudi BeyaertWalther Fiers

A1 Journal Article in TRENDS IN CELL BIOLOGY

A FAIRLY CONSERVED EPITOPE ON THE HEMAGGLUTININ OF INFLUENZA-A (H3N2) VIRUS WITH VARIABLE ACCESSIBILITY TO NEUTRALIZING ANTIBODY.

Peter VanlandschootEls BeirnaertS DEWILDEXavier SaelensT BESTEBROERJ DEJONGWilly Min JouWalther Fiers

A1 Journal Article in VIROLOGY

Anti-tumor activity of tumor necrosis factor in combination with interferon-gamma is not affected by prior tolerization.

N TAKAHASHIWalther FiersPeter Brouckaert

A1 Journal Article in INTERNATIONAL JOURNAL OF CANCER

BOTH TNF RECEPTORS ARE REQUIRED FOR TNF-MEDIATED INDUCTION OF APOPTOSIS IN PC60 CELLS.

Peter VandenabeeleWim DeclercqBart VanhaesebroeckJohan GrootenWalther Fiers

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Biologic therapy with TNF: preclinical studies

Bookchapter in Biologic therapy of cancer

Both TNF receptors are required for TNF-mediated induction of apoptosis in PC60 cells

Peter VandenabeeleWim DeclercqBart VanhaesebroeckJohan GrootenWalther Fiers

A2 Journal Article in J. Immunol.. 154, pp. 2904-2913

Casein kinase-1 phosphorylates the p75 tumor-necrosis-factor receptor and negatively regulates tumor-necrosis-factor signaling for apoptosis.

Rudi BeyaertBart VanhaesebroeckWim DeclercqJ VANLINTPeter VandenabeeleP AGOSTINISJR VANDENHEEDEWalther Fiers

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization of critical residues in the cytoplasmic domain of the human interleukin-5 receptor a chain required for growth signal-transduction.

S CORNELISI FACHEJ VANDERHEYDENYves GuisezJan TavernierR DEVOSWalther FiersG PLAETINCK

A1 Journal Article in EUROPEAN JOURNAL OF IMMUNOLOGY

Cloning and expression of cytokine genes

Roland ContrerasJan DemolderWalther Fiers

Bookchapter in Cytokines : a practical approach

Cytotoxicity in L929 murine fibrosarcoma cells after triggering of transfected human p75 tumour-necrosis-factor (TNF) receptor is mediated by endogenous murine TNF.

D VERCAMMENPeter VandenabeeleWim DeclercqM VANDECRAENJohan GrootenWalther Fiers

A1 Journal Article in CYTOKINE

Detailed analysis of the IL-5-IL-5Ra interaction - Characterization of crucial residues on the ligand and the receptor.

S CORNELISG PLAETINCKR DEVOSJ VANDERHEYDENJan TavernierCJ SANDERSONYves GuisezWalther Fiers

A1 Journal Article in EMBO JOURNAL

Dimerization of chimeric erythropoietin 75 kDa tumour-necrosis-factor (TNF) receptors transduces TNF signals - Necessity for the 75 kDa TNF-receptor transmembrane domain.

Wim DeclercqPeter VandenabeeleWalther Fiers

A1 Journal Article in CYTOKINE

Direct evidence for tumor necrosis factor-induced mitochondrial reactive oxygen intermediates and their involvement in cytotoxicity.

V GOOSSENSJohan GrootenK DEVOSWalther Fiers

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ENGINEERING OF THE CARBOHYDRATE MOIETY OF FUNGAL GLYCOPROTEINS TO A MAMMALIAN TYPE.

M MARASWalther FiersRoland Contreras

A1 Journal Article in PROTEIN ENGINEERING

Een reporter systeem voor immunodetectie, gebaseerd op lichtgevende, immunoglobuline G bindende bacteriën

Lothar SteidlerWalther Fiers

Evaluering van het IGA1 protease van Neisseria gonorrhoeae als expositiesysteem voor gecloneerde polypeptiden aan het oppervlak van Escherichia coli

Irmgard PoelaertWalther Fiers

Functionele analyse van het interleukine-5 receptor complex

Sigrid CornelisWalther Fiers

Generation and biological characterization of membrane-bound, uncleavable murine tumor-necrosis factor.

Els DecosterBart VanhaesebroeckPeter VandenabeeleJohan GrootenWalther Fiers

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Involvement of IFN-γ in Bacillus Calmette-Guérin-induced but not in tumor-induced sensitization to TNF-induced lethality

Anje CauwelsPeter BrouckaertJohan GrootenSui HuangMichel AguetWalther Fiers

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Mechanism of tolerance to tumor-necrosis-factor - Receptor-specific pathway and selectivity.

N TAKAHASHIPeter BrouckaertWalther Fiers

A1 Journal Article in AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Ontwerpen van een efficient en reguleerbaar expressiesysteem voor heterologe genen in cellen van dierlijke oorsprong

Peter VanhoenackerWalther Fiers

Optimalization and application in TNF-related models of a method to estimate NO production in vivo.

Wim Van MolleBart EveraerdtAnje CauwelsPeter BrouckaertWalther Fiers

PIONEERING WORK.

A1 Journal Article in SCIENCE

POLAR AGENTS WITH DIFFERENTIATION-INDUCING CAPACITY POTENTIATE TUMOR NECROSIS FACTOR-MEDIATED CYTOTOXICITY IN HUMAN MYELOID CELL-LINES.

S DEPRAETEREBart VanhaesebroeckWalther FiersJan WillemsM JONIAU

A1 Journal Article in JOURNAL OF LEUKOCYTE BIOLOGY

PRODUCTION OF SOLUBLE AND ACTIVE RECOMBINANT MURINE INTERLEUKIN-2 IN ESCHERICHIA-COLI - HIGH-LEVEL EXPRESSION, KIL-INDUCED RELEASE, AND PURIFICATION.

J ROBBENSA RAEYMAEKERSLothar SteidlerWalther FiersErik Remaut

A1 Journal Article in PROTEIN EXPRESSION AND PURIFICATION

Production in Escherichia coli of a functional murine and murine::human chimeric F(ab')2 fragment and mature antibody directed against human placental alkaline phosphatase

Daisy FlamezErik RemautWalther Fiers

A1 Journal Article in JOURNAL OF BIOTECHNOLOGY

Produktie van antilichamen, antilichaamderivaten en recombinante immunotoxines in Saccharomyces cerevisae

Wim LammerantWalther Fiers

REQUIREMENT OF AN ICE/CED-3 PROTEASE FOR FAS/APO-1-MEDIATED APOPTOSIS.

M LOSM VANDECRAENLC PENNINGH SCHENKM WESTENDORPPA BAEUERLEW DROGEPH KRAMMERWalther FiersK SCHULZEOSTHOFF

A1 Journal Article in NATURE

SECRETION OF BIOLOGICALLY-ACTIVE MURINE INTERLEUKIN-2 BY LACTOCOCCUS-LACTIS SUBSP LACTIS.

Lothar SteidlerJM WELLSA RAEYMAEKERSJoël VandekerckhoveWalther FiersErik Remaut

A1 Journal Article in APPLIED AND ENVIRONMENTAL MICROBIOLOGY

SIMULTANEOUS LIGHT-EMISSION FROM CLONED VIBRIO-FISCHERI LUX GENES AND EXPRESSION OF LAMB OR LAMB PROTEIN-A FUSION PROTEINS IN ESCHERICHIA-COLI DEPENDS ON USING A SINGLE CHIMERIC OPERON.

Lothar SteidlerWalther FiersErik Remaut

A1 Journal Article in BIOTECHNOLOGY AND BIOENGINEERING

Sensitisatie voor hTNF-geïnduceerde letaliteit in de muis : moleculaire dissectie van het mechanisme

Anje CauwelsWalther Fiers

Studie en identificatie door genclonering van een met de TNF-receptoren geassocieerde membraanstructuur

Carla Van DorpeWalther Fiers

TIGHT TRANSCRIPTIONAL CONTROL MECHANISM ENSURES STABLE HIGH-LEVEL EXPRESSION FROM T7 PROMOTER-BASED EXPRESSION PLASMIDS.

Nico MertensErik RemautWalther Fiers

A1 Journal Article in BIO-TECHNOLOGY

TNF-R55-SPECIFIC FORM OF HUMAN TUMOR-NECROSIS-FACTOR-ALPHA INDUCES COLLAGENASE GENE-EXPRESSION BY HUMAN SKIN FIBROBLASTS.

J WESTERMARCKL HAKKINENWalther FiersVM KAHARI

A1 Journal Article in JOURNAL OF INVESTIGATIVE DERMATOLOGY

TNF-induced mechanisms for IL6 gene induction

Guy HaegemanWalther Fiers

Tolerance as a strategy to broaden the therapeutic margin of tumor necrosis factor (TNF)

Nozomi TakahashiWalther Fiers

Two tumour necrosis factor receptors : structure and function

Peter VandenabeeleWim DeclercqRudi BeyaertWalther Fiers

A2 Journal Article in TRENDS IN CELL BIOLOGY

VERSATILE, MULTI-FEATURED PLASMIDS FOR HIGH-LEVEL EXPRESSION OF HETEROLOGOUS GENES IN ESCHERICHIA-COLI - OVERPRODUCTION OF HUMAN AND MURINE CYTOKINES.

Nico MertensErik RemautWalther Fiers

A1 Journal Article in GENE

1994

A BIFUNCTIONAL MURINE = HUMAN CHIMERIC ANTIBODY WITH ONE ANTIGEN-BINDING ARM REPLACED BY BACTERIAL BETA-LACTAMASE.

K DESUTTERWalther Fiers

A1 Journal Article in MOLECULAR IMMUNOLOGY

DISSOCIATION OF TNF-ALPHA CYTOTOXIC AND PROINFLAMMATORY ACTIVITIES BY P55 RECEPTOR-SELECTIVE AND P75 RECEPTOR-SELECTIVE TNF-ALPHA MUTANTS.

JAJ BARBARAWB SMITHJR GAMBLEXaveer VANOSTADEPeter VandenabeeleJan TavernierWalther FiersMA VADASAF LOPEZ

A1 Journal Article in EMBO JOURNAL

Efficient specific release of periplasmic proteins from Escherichia coli using temperature induction of cloned kil gene of pMB9.

Lothar SteidlerWalther FiersErik Remaut

A1 Journal Article in BIOTECHNOLOGY AND BIOENGINEERING

FUNCTIONAL REQUIREMENT OF THE 2 TNF RECEPTORS FOR INDUCTION OF APOPTOSIS IN PC60 CELLS AND THE ROLE OF MITOCHONDRIA IN TNF-INDUCED CYTOTOXICITY.

Peter VandenabeeleV GOOSSENSRudi BeyaertWim DeclercqJohan GrootenB VANHAESEBROECKM VANDECRAEND VERCAMMENB DEPUYDTG DENECKER et al.

A1 Journal Article in CIRCULATORY SHOCK

Het Major histocompatibility complex (MHC) van het varken : isolatie, karakterisatie en kartering van een aantal genen

Luc PeelmanWalther FiersY. Bouquet

Human interferon-beta, expressed in Saccharomyces cerevisiae, is predominantly directed to the vacuoles. Influence of modified co-expression of secretion factors and chaperones

Jan DemolderWalther FiersRoland Contreras

A1 Journal Article in JOURNAL OF BIOTECHNOLOGY

Human tumor necrosis factor mutants with preferential binding to and activity on either the R55 or R75 receptor.

Xaveer Van OstadePeter VandenabeeleJan TavernierWalther Fiers

A1 Journal Article in EUROPEAN JOURNAL OF BIOCHEMISTRY

Mechanism of induction of tolerance to tumour-necrosis-factor (TNF): No involvement of modulators of TNF bioavailability or receptor-binding.

Nozomi TakahashiPeter BrouckaertMHA BEMELMANSWA BUURMANWalther Fiers

A1 Journal Article in CYTOKINE

Modulation of the release of cytokines and reduction of the shock syndrome induced by anti-CD3 monoclonal-antibody in mice by interleukin-10.

V DONCKIERV FLAMENTC GERARDD ABRAMOWICZPeter VandenabeeleM WISSINGA DELVAUXWalther FiersO LEOT VELU et al.

A1 Journal Article in TRANSPLANTATION

Molecular mechanisms of tumor necrosis factor-induced cytotoxicity - What we do understand and what we do not.

Rudi BeyaertWalther Fiers

A1 Journal Article in FEBS LETTERS

Oppervlakte-expositie van streptavidine in Escherichia coli; biotechnologische implicaties

Jasmine ViaeneWalther Fiers

Production of enzymatically active-rat protein disulfide-isomerase in Escherichia-coli.

K DESUTTERK HOSTENSJoël VandekerckhoveWalther Fiers

A1 Journal Article in GENE

Protection by alpha(1)-acid glycoprotein against tumor necrosis factor-induced lethality.

Claude LibertPeter BrouckaertWalther Fiers

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

Receptor-selective mutants of tumour necrosis factor in the therapy of cancer : preclinical studies

Peter BrouckaertPaul AmelootAnje CauwelsBart EveraerdtClaude LibertNozomi TakahashiWim Van MolleWalther Fiers

A1 Journal Article in CIRCULATORY SHOCK

Recombinant IL-1 receptor antagonist protects against TNF-induced lethality in mice.

Bart EveraerdtPeter BrouckaertWalther Fiers

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Recombinant influenza virus neuraminidase : secretie, zuivering en immunologische karakterisering

Tom DerooWalther Fiers

Response of interleukin-6-deficient mice to tumor necrosis factor-induced metabolic changes and lethality.

Claude LibertNozomi TakahashiAnje CauwelsPeter BrouckaertH BLUETHMANNWalther Fiers

A1 Journal Article in EUROPEAN JOURNAL OF IMMUNOLOGY

Structure-activity studies of human tumour necrosis factors.

Xaveer Van OstadeJan TavernierWalther Fiers

A1 Journal Article in PROTEIN ENGINEERING

Studie van de oplosbaarheid van recombinante eiwitten in Escherichia coli

Johan RobbensWalther Fiers

Studies on the induction of the interleukin-6 promoter in cell lines of human and simian origin.

Peter VanhoenackerWalther FiersGuy Haegeman

A1 Journal Article in EUROPEAN CYTOKINE NETWORK

Synthese van muis en muis-mens chimere antilichamen, antilichaamfragmenten en immunotoxines in Escherichia coli

Daisy FlamezWalther Fiers

THE 2 GENES ENCODING YEAST RIBOSOMAL-PROTEIN S8 RESIDE ON DIFFERENT CHROMOSOMES, AND ARE CLOSELY LINKED TO THE HSP70 STRESS PROTEIN GENE-SSA3 AND GENE-SSA4.

M LOGGHEFrancis MolemansWalther FiersRoland Contreras

A1 Journal Article in YEAST

The two genes encoding yeast ribosomal protein S8 reside on different chromosomes, and are closely linked to the hsp7O stress protein genes SSA3 and SSA4.

Marc LoggheFrancis MolemansWalther FiersRoland Contreras

A2 Journal Article in YEAST

1993

A new method for purification of influenza neuraminidase released by pronase digestion.

Tom DerooWilly Min JouWalther Fiers

ACTIVATION OF THE NUCLEAR FACTOR-KAPPA-B IS NOT SUFFICIENT FOR REGULATION OF TUMOR NECROSIS FACTOR-INDUCED INTERLEUKIN-6 GENE-EXPRESSION.

NP PATESTOSGuy HaegemanVeronique VandevoordeWalther Fiers

A1 Journal Article in BIOCHIMIE

CELL-MEMBRANE PERMEABILIZATION AND CELLULAR COLLAPSE, FOLLOWED BY LOSS OF DEHYDROGENASE-ACTIVITY - EARLY EVENTS IN TUMOR NECROSIS FACTOR-INDUCED CYTOTOXICITY.

Johan GrootenV GOOSSENSBart VanhaesebroeckWalther Fiers

A1 Journal Article in CYTOKINE

Construction of a mouse and a mouse-human chimeric immunotoxin on the genetic level and production of functional protein in E. coli

Daisy FlamezErik RemautWalther Fiers

Cyclooxygenase inhibitors prevent the induction of tolerance to the toxic effects of tumor necrosis factor.

Nozomi TakahashiPeter BrouckaertWalther Fiers

A1 Journal Article in JOURNAL OF IMMUNOTHERAPY

Depletion of the mitochondrial electron transport abrogates the cytotoxic and gene-inductive effects of TNF.

K SCHULZEOSTHOFFRudi BeyaertVeronique VandevoordeGuy HaegemanWalther Fiers

A1 Journal Article in EMBO JOURNAL

Down regulation of E-cadherin during experimental tumor formation in syngeneic mice and in human colorectal tumors

Yan GaoWalther Fiers

ENHANCEMENT OF TUMOR-NECROSIS-FACTOR CYTOTOXICITY BY LITHIUM-CHLORIDE IS ASSOCIATED WITH INCREASED INOSITOL PHOSPHATE ACCUMULATION.

Rudi BeyaertKaren HeyninckDirk De ValckF BOEYKENSFrans Van RoyWalther Fiers

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Effect of bcl-2-proto-oncogene expression on cellular sensitivity to tumor necrosis factor-mediated cytotoxicity.

Bart VanhaesebroeckJC REEDD DEVALCKJohan GrootenT MIYASHITAS TANAKARudi BeyaertFrans Van RoyWalther Fiers

A1 Journal Article in ONCOGENE

Expression, purification and crystallization of fully active, glycosylated human interleukin-5

Yves GuisezC OEFNERFK WINKLERE SCHLAEGERM ZULAUFJ VAN DER HEYDENG PLAETINCKSigrid CornelisJan TavernierWalther Fiers et al.

A3 Journal Article in FEBS Lett., 331

Folding of the MS2 coat protein in Escherichia coli is modulated by translational pauses resulting from mRNA secondary structure and codon usage : a hypothesis

Yves GuisezJohan RobbensErik RemautWalther Fiers

A1 Journal Article in JOURNAL OF THEORETICAL BIOLOGY

Functional exposition of streptavidin at the surface of Escherichia coli using the IgAß domain of the IgA protease of Neisseria gonorrhoea.

Irmgard PoelaertC FERRAGUTJasmine ViaeneWalther FiersErik Remaut

HIGH-LEVEL EXPRESSION, PURIFICATION, AND RENATURATION OF RECOMBINANT MURINE INTERLEUKIN-2 FROM ESCHERICHIA-COLI

Yves GuisezJan DemolderNico MertensAlex RaeymaekersGeert PlaetinckJohan RobbensJoël VandekerckhoveErik RemautWalther Fiers

A1 Journal Article in PROTEIN EXPRESSION AND PURIFICATION

HUMAN TNF MUTANTS WITH SELECTIVE ACTIVITY ON THE P55 RECEPTOR.

Xaveer Van OstadePeter VandenabeeleBart EveraerdtH LOETSCHERR GENTZM BROCKHAUSW LESSLAUERJan TavernierPeter BrouckaertWalther Fiers

A1 Journal Article in NATURE

INCREASED IL-6 PRODUCTION AND IL-6-MEDIATED IG SECRETION IN MURINE HOST-VS-GRAFT DISEASE.

Peter VandenabeeleD ABRAMOWICZD BERUSJ VANDERHEYDENJohan GrootenV DONCKIEREL HOOGHEPETERSM GOLDMANWalther Fiers

A1 Journal Article in JOURNAL OF IMMUNOLOGY

INTERLEUKIN-10 REDUCES THE RELEASE OF TUMOR-NECROSIS-FACTOR AND PREVENTS LETHALITY IN EXPERIMENTAL ENDOTOXEMIA.

C GERARDC BRUYNSA MARCHANTD ABRAMOWICZPeter VandenabeeleA DELVAUXWalther FiersM GOLDMANT VELU

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

Increase of the soluble fraction of human interferon-y expressed in Escherichia coli, due to the chaperonin activity of GroEL/ES.

Johan RobbensErik RemautWalther Fiers

LamB as a carrier molecule for the functional exposition of IgG-binding domains of the Staphylococcus aureus protein A at the surface of Escherichia coli K12.

Lothar SteidlerErik RemautWalther Fiers

A1 Journal Article in MOLECULAR AND GENERAL GENETICS

Molekulair biologische werking van tumor nekrosis faktor : sensitisatie door lithium-ionen en staurosporine

Rudi BeyaertWalther Fiers

Ontwerpen van een detektorgensysteem voor promotoranalyse, steunend op sekreteerbare enzymaktiviteit

Veerle Vande VijverWalther Fiers

Pap pili as a vector system for surface exposition of an immunoglobulin G-binding domain of protein-A of Staphylococcus-aureus in Escherichia-coli.

Lothar SteidlerErik RemautWalther Fiers

A1 Journal Article in JOURNAL OF BACTERIOLOGY

Phenotypic effects in Saccharomyces cerevisiae after regulated expression of beta-(l,3)-glucanase from Nicotiana plumbaginifolia

Jan DemolderM De BackerWalther FiersRoland Contreras

A1 Journal Article in JOURNAL OF BIOTECHNOLOGY

Production of enzymatically active rat protein disulfide isomerase in COS-1 cells.

Kristine De SutterWalther Fiers

Protection against tumor necrosis factor-induced lethality

Claude LibertBart EveraerdtNozomi TakahashiAnje CauwelsPeter BrouckaertWalther Fiers

Recombinant secreted haemagglutinin protects mice against a lethal challenge of influenza virus

Peter VanlandschootGeert MaertensWilly Min JouWalther Fiers

A1 Journal Article in VACCINE

Relations between tumor necrosis factor, interleukin-6 and the liver in a murine model

Claude LibertWalther Fiers

Sensitization of tumor cells to tumor necrosis factor action by the protein kinase inhibitor staurosporine

Rudi BeyaertBart VanhaesebroeckKaren HeyninckElke BooneDirk De ValckKlaus Schulze-OsthoffGuy HaegemanFrans Van RoyWalther Fiers

A1 Journal Article in CANCER RESEARCH

Strategies to broaden the therapeutic margin of tumor necrosis factor

Peter BrouckaertBart EveraerdtClaude LibertNozomi TakahashiAnje CauwelsWalther Fiers

Struktuur-funktie onderzoek van tumor nekrosis faktor

Xaveer Van OstadeWalther Fiers

Studie van het humaan immuunantwoord tegen hepatitis B virus

Els Van HeckeGeert Leroux-RoelsWalther Fiers

Studies on the inducibility of the IL6 promoter using a reporter gene construction.

Wim Vanden BergheGuy HaegemanWalther Fiers

T7-RNA-polymerase terminates at poly-A regions on plasmids.

Nico MertensErik RemautWalther Fiers

TUMOR-NECROSIS-FACTOR ACTIVATES HUMAN ENDOTHELIAL-CELLS THROUGH THE P55-TUMOR NECROSIS FACTOR-RECEPTOR BUT THE P75-RECEPTOR CONTRIBUTES TO ACTIVATION AT LOW TUMOR-NECROSIS-FACTOR CONCENTRATION.

MR SLOWIKLG DELUCAWalther FiersJordan S POBER

A1 Journal Article in AMERICAN JOURNAL OF PATHOLOGY

TUMOR-NECROSIS-FACTOR CYTOTOXICITY IS ASSOCIATED WITH PHOSPHOLIPASE-D ACTIVATION.

D DEVALCKRudi BeyaertFrans Van RoyWalther Fiers

A1 Journal Article in EUROPEAN JOURNAL OF BIOCHEMISTRY

TUMOR-NECROSIS-FACTOR, ITS RECEPTORS AND THE CONNECTION WITH INTERLEUKIN-1 AND INTERLEUKIN-6.

Peter BrouckaertClaude LibertB EVERAERDTNozomi TakahashiAnje CauwelsWalther Fiers

A1 Journal Article in IMMUNOBIOLOGY

Translational coupling: the importance of the translational efficiency of the first cistron.

Nico MertensErik RemautWalther Fiers

Tumor necrosis factor cytotoxicity is associated with activation of cellular phospholipases

Dirk De ValckRudi BeyaertFrans Van RoyWalther Fiers

Tumor necrosis factor: molecular and cellular biology and clinical relevance

Walther FiersWim A Buurman

Tumour necrosis factor

Bookchapter in Humoral factors

Two pathways of tumor necrosis factor signal transduction: in vitro and in vivo implications

Walther FiersRudi BeyaertPeter BrouckaertAnje CauwelsWim DeclercqDirk De ValckB EveraerdtVera GoossensJohan GrootenGuy Haegeman et al.

1992

Application of fluorescence in situ hybridization in clinical cytogenetics, cancer cytogenetics and gene mapping

Frank SpelemanWalther FiersJ. G. Leroy

COLEY VACCINE AND TNF THERAPY.

Peter BrouckaertWalther FiersFJ LEJEUNE

A1 Journal Article in NATURE

Cloning and expression of the canine interferon-gamma gene.

K DEVOSF DUERINCKK VANAUDENHOVEWalther Fiers

A1 Journal Article in JOURNAL OF INTERFERON RESEARCH

Cytotoxic activity of tumor necrosis factor is mediated by early damage of mitochondrial functions. Evidence for the involvement of mitochondrial radical generation.

K SCHULZEOSTHOFFAC BAKKERBart VanhaesebroeckRudi BeyaertWA JACOBWalther Fiers

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Disulphide bridge formation in the periplasm of Escherichia-coli: betalactamase: human IgG3 hinge fusions as a model system.

K DESUTTERErik RemautWalther Fiers

A1 Journal Article in MOLECULAR MICROBIOLOGY

Efficient synthesis of secreted murine interleukin-2 by Saccharomyces cerevisiae: Influence of 3'-untranslated regions and codon usage.

Jan DemolderWalther FiersRoland Contreras

A1 Journal Article in GENE

Expression of an exogenous tumor-necrosis-factor (TNF) gene in TNF-sensitive cell-lines confers resistance to TNF-mediated cell-lysis.

Bart VanhaesebroeckEls DecosterXaveer VAN OSTADES VANBLADELAnne LenaertsFrans Van RoyWalther Fiers

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Functional characterization of the human tumor necrosis factor receptor p75 in a transfected rat/mouse T cell hybridoma

Peter VandenabeeleWim DeclercqDominique VercammenMarc Van De CraenJohan GrootenHansruedi LoetscherManfred BrockhausWerner LesslauerWalther Fiers

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

Limited involvement of interleukin-6 in the pathogenesis of lethal septic shock as revealed by the effect of monoclonal antibodies against interleukin-6 or its receptor in various murine models

Claude LibertAnne VinkPierre CouliePeter BrouckaertBart EveraerdtJacques Van SnickWalther Fiers

A1 Journal Article in EUROPEAN JOURNAL OF IMMUNOLOGY

Molecular basis of the membrane-anchored and two soluble isoforms of the human interleukin-5 receptor alpha-subunit.

Jan TavernierT TUYPENSG PLAETINCKA VERHEEWalther FiersR DEVOS

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Muis interleukine 4 : expressie in heterologe gastheersystemen en zuivering

Filip HanssensWalther Fiers

Optimalisatie van heterologe genexpressie in Saccharomyces cerevisiae

Jan DemolderWalther Fiers

Organization and chromosomal localization of the human interleukin 5 receptor cc-chain gene

T TuypensG PlaetinckE BakerG SutherlandGuy BrusselleWalther FiersR DevosJan Tavernier

A2 Journal Article in EUROPEAN CYTOKINE NETWORK

Potentiation of tumour necrosis factor-mediated activities by lithium salts: a review

Rudi BeyaertWalther Fiers

A2 Journal Article in LITHIUM

Production of functionally active murine and murine::human chimeric F(ab')2 fragments in COS-1 cells.

K DESUTTERV FEYSAndré Van de VoordeWalther Fiers

A1 Journal Article in GENE

Selective species specificity of tumor-necrosis-factor for toxicity in the mouse.

Peter BrouckaertClaude LibertBart EveraerdtWalther Fiers

A1 Journal Article in LYMPHOKINE AND CYTOKINE RESEARCH

Stimulation of lipolysis in cultured fat cells by tumor necrosis factor, interleukin-1, and the interferons is blocked by inhibition of prostaglandin synthesis.

KR FEINGOLDW DOERRLERCA DINARELLOWalther FiersC GRUNFELD

A1 Journal Article in ENDOCRINOLOGY

Synergistic induction of interleukin-6 by tumor necrosis factor and lithium chloride in mice: Possible role in the triggering and exacerbation of psoriasis by lithium treatment.

Rudi BeyaertK SCHULZEOSTHOFFFrans Van RoyWalther Fiers

A1 Journal Article in EUROPEAN JOURNAL OF IMMUNOLOGY

TNF-mediated IL6 gene expression and cytotoxicity are co-inducible in TNF resistant L929 cells

Veronique VandevoordeGuy HaegemanWalther Fiers

A1 Journal Article in FEBS LETTERS

TUMOR-NECROSIS-FACTOR STIMULATES MULTIPLE SERINE THREONINE PROTEIN-KINASES IN SWISS 3T3 AND L929 CELLS - IMPLICATION OF CASEIN KINASE-2 AND EXTRACELLULAR SIGNAL-REGULATED KINASES IN THE TUMOR-NECROSIS-FACTOR SIGNAL TRANSDUCTION PATHWAY.

J VANLINTP AGOSTINISVeronique VandevoordeGuy HaegemanWalther FiersW MERLEVEDEJR VANDENHEEDE

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

The glucocorticoid antagonist RU38486 mimics inicrleukin-1 in its sensitization to the lethal and interleukin-6-inducing properties of tumor-necrosis-factor.

Peter BrouckaertBart EveraerdtWalther Fiers

A1 Journal Article in EUROPEAN JOURNAL OF IMMUNOLOGY

The invasion suppressor role of E-cadherin

Frans Van RoyK VleminckxLuc VakaetGeert BerxWalther FiersMarcus Mareel

Bookchapter in Metastasis : basic research and its clinical applications

Tumor-necrosis-factor : mechanism of action at the molecular, cellular and in vivo level

Walther FiersRudi BeyaertPeter BrouckaertEls DecosterDirk De ValckBart EveraerdtJohan GrootenAnne LenaertsClaude LibertK. Schulzeosthoff et al.

1991

A human high affinity interleukin-5 receptor (IL5R) is composed of an IL5-specific α chain and a β chain shared with the receptor for GM-CSF

Jan TavernierRené DevosSigrid CornelisTania TuypensJosé Van der HeydenWalther FiersGeert Plaetinck

A1 Journal Article in CELL

Amino acid sequence analysis of a mouse interleukin 5 receptor protein reveals homology with a mouse interleukin 3 receptor protein

René DevosJoël VandekerckhoveAntonius RolinkGeert PlaetinckJosé Van der HeydenWalther FiersJan Tavernier

A1 Journal Article in EUROPEAN JOURNAL OF IMMUNOLOGY

Characterization of the murine IL-5 receptor complex with the use of a panel of monoclonal antibodies: relationship to the murine IL-3 receptor

José Van der HeydenRéné DevosGeert PlaetinckIna FacheWalther FiersJan Tavernier

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Constructie en expressie van genen coderend voor heterodimere muis-mens chimerische F(AB')2-fragmenten als basis voor de ontwikkeling van bisspecifieke monovalente antilichamen

Kristine De SutterWalther Fiers

Cytokine release syndrome induced by the 145-2C11 anti-CD3 monoclonal antibody in mice: prevention by high doses of methylprednisolone

Maria-Luisa AlegrePeter VandenabeeleMichel DepierreuxSandrine FlorquinMonique Deschodt-LanckmanVeronique FlamandMuriel MoserOberdan LeoJacques UrubainWalther Fiers et al.

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Down-regulation of E-cadherin expression in Madin Darby canine kidney (MDCK) cells inside tumors of nude mice

M MAREELJ BEHRENSW BIRCHMEIERGeorges De BruyneK VLEMINCKXA HOOGEWUSWalther FiersFrans Van Roy

A2 Journal Article in Int. J. Cancer, 47, 922-928

Effects of interleukin 6 and leukemia inhibitory factor on the acute phase response and DNA synthesis in cultured rat hepatocytes

T KordulaH RokitaA KojWalther FiersJ GauldieH Baumann

A1 Journal Article in LYMPHOKINE AND CYTOKINE RESEARCH

Effects of tumor necrosis factor on prostacyclin production and the barrier function of human endothelial cell monolayers

EG LangelerWalther FiersVWH Van Hinsbergh

A1 Journal Article in ARTERIOSCLEROSIS AND THROMBOSIS

Efficient KEX2-like processing of a glucoamylase-interleukin-6 fusion protein by Aspergillus nidulans and secretion of mature interleukin-6

Roland ContrerasDirk CarrezJames R KinghornCees AMJJ van den HondelWalther Fiers

A1 Journal Article in BIO-TECHNOLOGY

Expression of the tumor necrosis factor gene in tumor cells correlates with reduced tumorigenicity and reduced invasiveness in vivo

Bart VanhaesebroeckMarcus MareelFrans Van RoyJohan GrootenWalther Fiers

A1 Journal Article in CANCER RESEARCH

GENETIC MANIPULATION OF E-CADHERIN EXPRESSION BY EPITHELIAL TUMOR-CELLS REVEALS AN INVASION SUPPRESSOR ROLE.

Kris VleminckxLuc VakaetMarcus MareelWalther FiersFrans Van Roy

A1 Journal Article in CELL

Induction of inflammatory cell infiltration and necrosis in normal mouse skin by the combined treatment of tumor-necrosis-factor and lithium-chloride

Rudi BeyaertChristian De PotterBart VanhaesebroeckFrans Van RoyWalther Fiers

A1 Journal Article in AMERICAN JOURNAL OF PATHOLOGY

Induction of tolerance allows separation of lethal and antitumor activities of tumor necrosis factor in mice

Nozomi TakahashiPeter BrouckaertWalther Fiers

A1 Journal Article in CANCER RESEARCH

Interleukin 4 inhibits stimulation of hepatic lipogenesis by tumor necrosis factor, interleukin 1, and interleukin 6 but not by interferon-α

Carl GrunfeldMounzer SouedSaleh AdiArthur H MoserWalther FiersCharles A DinarelloKenneth R Feingold

A1 Journal Article in CANCER RESEARCH

Interleukin-6 enhances the expression of tumor necrosis factor receptors on hepatoma cells and hepatocytes

Sigrid Van BladelClaude LibertWalther Fiers

A1 Journal Article in CYTOKINE

Invloed van basale membraan moleculen op adhesie en migratie van borsttumor cellen

Peter CoopmanMarc MareelWalther Fiers

Involvement of the liver, but not of IL-6, in IL-1-induced desensitization to the lethal effects of tumor necrosis factor

Claude LibertSigrid Van BladelPeter BrouckaertAlan ShawWalther Fiers

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Is amyloidogenesis during Alzheimer's disease due to an IL-1-/IL-6-mediated 'acute phase response' in the brain?

Peter VandenabeeleWalther Fiers

Editorial material

Klonering, sekwentie-analyse en expressie van het RNA polymerasegen van het tabaksnecrose virus

Xavier SaelensWalther Fiers

Lithium chloride potentiates tumor necrosis factor-induced and interleukin 1-induced cytokine and cytokine receptor expression

Rudi BeyaertKlaus Schulze-OsthoffFrans Van RoyWalther Fiers

A1 Journal Article in CYTOKINE

Localization of the active site of human tumour necrosis factor (hTNF) by mutational analysis

Xaveer Van OstadeJan TavernierThierry PrangéWalther Fiers

A1 Journal Article in EMBO JOURNAL

Molecular basis of a high affinity murine interleukin-5 receptor

René DevosGeert PlaetinckJosé Van der HeydenSigrid CornelisJoël VandekerckhoveWalther FiersJan Tavernier

A1 Journal Article in EMBO JOURNAL

Precursor structures and structure-function analysis of TNF and lymphotoxin

Bookchapter in Tumor necrosis factors : structure, function, and mechanism of action

Production and purification of recombinant human interleukin-6 secreted by the yeast Saccharomyces cerevisiae

Yves GuisezBernard TisonJoël VandekerckhoveJan DemolderGuy BauwGuy HaegemanWalther FiersRoland Contreras

A1 Journal Article in EUROPEAN JOURNAL OF BIOCHEMISTRY

Spontane en ras-geïnduceerde maligne progressie van muis lens cellen

Ludwine MessiaenM. MareelWalther Fiers

Studie van de receptoren voor tumor necrosis factor : biochemische eigenschappen, expressie en regulatie

Sigrid Van BladelWalther Fiers

The influence of modulating substances on tumor necrosis factor and interleukin-6 levels after injection of murine tumor necrosis factor or lipopolysaccharide in mice

Claude LibertSigrid Van BladelPeter BrouckaertWalther Fiers

A1 Journal Article in JOURNAL OF IMMUNOTHERAPY

The nucleotide sequence of a third cyclophilin-homologous gene from Saccharomyces cerevisiae

L FrancoA JiménezJan DemolderFrancis MolemansWalther FiersRoland Contreras

A1 Journal Article in YEAST

Tumor necrosis factor induces apoptosis (programmed cell death) in normal endothelial cells in vitro

Bernard RobayeRoger MosselmansWalther FiersJacques E DumontPaul Galand

A1 Journal Article in AMERICAN JOURNAL OF PATHOLOGY

Tumor necrosis factor-induced interleukin-6 expression and cytotoxicity follow a common signal transduction pathway in L929 cells

Veronique VandevoordeGuy HaegemanWalther Fiers

A1 Journal Article in BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Tumor necrosis factor: characterization at the molecular, cellular and in vivo level

A1 Journal Article in FEBS LETTERS

Tumour-necrosis-factor-mediated cytotoxicity is correlated with phospholipase-A2 activity, but not with arachidonic acid release per se

Philip SuffysRudi BeyaertDirk De ValckBart VanhaesebroeckFrans Van RoyWalther Fiers

A1 Journal Article in EUROPEAN JOURNAL OF BIOCHEMISTRY

Two discrete types of tumor necrosis factor-resistant cells derived from the same cell line

Bart VanhaesebroeckSigrid Van BladelAnne LenaertsPhilippe SuffysRudi BeyaertRudolf LucasFrans Van RoyWalther Fiers

A1 Journal Article in CANCER RESEARCH

1990

Analysis of the structure-function relationship of tumour necrosis factor: human/mouse chimeric TNF proteins: general properties and epitope analysis

Jan TavernierAnne MarmenoutRita BaudenGuido HauquierXaveer Van OstadeWalther Fiers

A1 Journal Article in JOURNAL OF MOLECULAR BIOLOGY

Biologische karakterisering van cytokines : rol van interleukines (IL-1, IL-2, IL-4, IL-5, IL-6) en andere cytokines (GM-CSF) in B- en T-cell systemen en in autoimmuniteit

Peter VandenabeeleWalther Fiers

Characterization of interleukin 5 receptors on eosinophilic sublines from human promyelocytic leukemia (HL-60) cells

Geert PlaetinckJosé Van der HeydenJan TavernierIna FachéTania TuypensSteven FischkoffWalther FiersRené Devos

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

Comparative activity of human and murine tumor necrosis factor in toxicity and anti-infectious assays in mice

Francine ParantJan TavernierWalther FiersMonique Parant

A1 Journal Article in MICROBIAL PATHOGENESIS

Cytotoxic activity of tumor necrosis factor is inhibited by amiloride derivatives without involvement of the Na+/H+ antiporter

B VanhaesebroeckEJ Jr CragoeJ PouysségurRudi BeyaertFrans Van RoyWalther Fiers

A1 Journal Article in FEBS LETTERS

Development of a simple, sensitive and specific bioassay for interleukin-1 based on the proliferation of RPMI 1788 cells: comparison with other bioassays for IL-1

Peter VandenabeeleWim DeclercqClaude LibertWalther Fiers

A1 Journal Article in JOURNAL OF IMMUNOLOGICAL METHODS

Expression of the murine interleukin-5 receptor on Xenopus laevis oocytes

René DevosJan TavernierGeert PlaetinckJosé Van der HeydenAntonius RolinkWalther Fiers

A1 Journal Article in BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Growth of CD34+ acute myeloblastic-leukemia colony-forming cells in response to recombinant hematopoietic growth-factors

C CarlostellaL MangoniC AlmiciF FrassoniWalther FiersV Rizzoli

A1 Journal Article in LEUKEMIA

HORMONE SENSITIVITY INVITRO AND INVIVO OF V-RAS-TRANSFECTED MCF-7 CELL DERIVATIVES.

Frans Van RoyMarcus MareelKris VleminckxRudi BeyaertWalther FiersN DEVLEESCHOUWERC MUQUARDTN LEGROSMarc BrackeG LECLERCQ

A1 Journal Article in INTERNATIONAL JOURNAL OF CANCER

Heterologous gene expression by filamentous fungi: secretion of human interleukin-6 by Aspergillus nidulans

Dirk CarrezWouter JanssensPatrick DegraveCees AMJJ van den HondelJames R KinghornWalther FiersRoland Contreras

A1 Journal Article in GENE

Hypothermia and hypoglycemia induced by anti-CD3 monoclonal antibody in mice : role of tumor necrosis factor

Marisa AlegrePeter VandenabeeleVéronique FlamandMuriel MoserOberdan LeoDaniel AbramowiczJacques UrbainWalther FiersMichel Goldman

A1 Journal Article in EUROPEAN JOURNAL OF IMMUNOLOGY

IL-4 acts synergistically on the IL-2 response of an autoreactive T-cell clone ; synergism correlates with increased intracellular IL-2, but not with a modified IL-2 receptor expression

Peter VandenabeeleJohan GrootenWalther Fiers

A1 Journal Article in CELLULAR IMMUNOLOGY

In vitro and in vivo action of tumor necrosis factor

Walther FiersRudi BeyaertPeter BrouckaertBart EveraerdtGuy HaegemanClaude LibertPhilip SuffysNozomi TakahashiJan TavernierSigrid Van Bladel et al.

Induction of interleukin 6 by human and murine recombinant interleukin 1 in mice

Claude LibertPeter BrouckaertAlan ShawWalther Fiers

A1 Journal Article in EUROPEAN JOURNAL OF IMMUNOLOGY

Inhibition by glucocorticoids of tumor necrosis factor-mediated cytotoxicity: evidence against lipocortin involvement

Rudi BeyaertPhilip SuffysFrans Van RoyWalther Fiers

A1 Journal Article in FEBS LETTERS

Intraperitoneal secretion of interleukin-6 during continuous ambulatory peritoneal dialysis

Michel GoldmanPeter VandenabeeleJean MoulartZoulika AmraouiDaniel AbramowiczJoëlle NortierJean-Louis VanherweghemWalther Fiers

A1 Journal Article in NEPHRON

Modulation of cellular susceptibility to the cytotoxic/cytostatic action of tumor necrosis factor by adenovirus E1 gene expression is cell type-dependent

Bart VanhaesebroeckH Th Marc TimmersGijsbertus J PronkFrans Van RoyAlex J van der EbWalther Fiers

A1 Journal Article in VIROLOGY

Onderzoek naar de mechanismen van cytokine-gemedieerde anti-tumorale aktiviteit

Bart VanhaesebroeckWalther Fiers

Ontwikkeling van een detektietechniek voor snelle analyse van mutanten voor struktuur-funktie relatie onderzoek van eiwitten

Erwin SablonWalther Fiers

PARTIAL TRANSFORMATION OF HUMAN TUMOR-CELL LINES SHOWING DEFECTIVE INTERACTION BETWEEN UNUSUAL P53 GENE-PRODUCT AND SV40 LARGE-T ANTIGEN.

Frans Van RoyG LIEBAUTMarcus MareelWalther Fiers

A1 Journal Article in ONCOGENE

Produktie en zuivering van cytokines verkregen door recombinant-DNA-technologie

Yves GuisezWalther Fiers

Response of murine cell lines to an IL-1/IL-2 induced factor in a rat mouse T hybridoma (PC60) : differential induction of cytokines by human IL-1α and IL-1β and partial amino acid sequence of rat GM-CSF

Peter VandenabeeleYves GuisezWim DeclercqGuy BauwJoël VandekerckhoveWalther Fiers

A1 Journal Article in LYMPHOKINE RESEARCH

Role of tumor necrosis factor in flavone acetic acid-induced tumor vasculature shutdown

Viswanath MahadevanSaleem TA MalikAnthony MeagerWalther FiersGraham P LewisIan R Hart

A1 Journal Article in CANCER RESEARCH

Search for mediators of the lipogenic effects of tumor necrosis factor: potential role for interleukin 6

Carl GrunfeldSaleh AdiMounzer SouedArthur MoserWalther FiersKenneth R Feingold

A1 Journal Article in CANCER RESEARCH

The complex effects of recombinant tumour necrosis factor α (rhTNFα) in human ovarian cancer xenograft models

STA MalikDB GriffinMS NaylorWalther FiersA OliffFR Balkwill

Transforming growth factor-β and epidermal growth factor modulate basal and interleukin-6-induced amino acid uptake and acute phase protein synthesis in cultured rat hepatocytes

J BeretaK SzubaWalther FiersJ GauldieA Koj

A1 Journal Article in FEBS LETTERS

Tumor necrosis factor induces the production of urokinase-type plasminogen activator by human endothelial cells

Victor WM van HinsberghEva A van den BergWalther FiersGerard Dooijewaard

A1 Journal Article in BLOOD

Tumor-necrosis-factor : mechanism of action at the molecular, cellular and in vivo level

Walther FiersRudi BeyaertPeter BrouckaertBart EveraerdtJohan GrootenAnne LenaertsClaude LibertP. SuffysNozomi TakahashiJan Tavernier et al.

A1 Journal Article in SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION

1989

A role for Interleukin-1 in the invivo actions of tumor necrosis factor

Peter BrouckaertClaude LibertBart EveraerdtNozomi TakahashiWalther Fiers

A1 Journal Article in LYMPHOKINE RESEARCH

Acquisition by the murine host of responsiveness toward various neoplastic cell lines, but not toward self, through adoptive transfer of a helper T-lymphocyte clone with antiself specificity

Johan GrootenWalther Fiers

A1 Journal Article in CANCER RESEARCH

An ongoing in vivo immune response affects the abundancy and differentiation of lymphokine-activated killer cell precursors, but does not influence their broad spectrum target reactivity

Bart VanhaesebroeckJohan GrootenWalther Fiers

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Circulating interleukin 6 during a continuous infusion of tumor necrosis factor and interferon γ

Peter BrouckaertDavid R SpriggsGeorge DemetriDonald W KufeWalther Fiers

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

Correlation between temperature-dependent cytoplasmic solubility and periplasmic export of a heterologous protein in Escherichia coli

Ronny LeemansErik RemautWalther Fiers

A1 Journal Article in GENE

Different preparations of natural and recombinant human interleukin-6 (ifn-β2, bsf-2) similarly stimulate acute phase protein synthesis and uptake of α-aminoisobutyric acid by cultured rat hepatocytes

J BeretaA KurdowskaA KojT HiranoT KishimotoJean ContentWalther FiersJ Van DammeJ Gauldie

A1 Journal Article in INTERNATIONAL JOURNAL OF BIOCHEMISTRY

Different pro-inflammatory profiles of interleukin 1 (IL 1) and tumor necrosis factor (TNF) in an in vivo model of inflammation

M RampartWalther FiersW De SmetAG Herman

A1 Journal Article in AGENTS AND ACTIONS

EFFECT OF ONCOGENE TRANSFECTION OR PASSAGE INVIVO ON MALIGNANT PHENOTYPES OF RAT2-CELLS.

Frans Van RoyP COOPMANPhilip SuffysG LIEBAUTKris VleminckxJ GAOCH DRAGONETTIWalther FiersMarcus Mareel

A1 Journal Article in ANTICANCER RESEARCH

Export van eukaryote eiwitten in Escherichia coli

Ronny LeemansWalther Fiers

Expressie in eukaryote cellen van rekombinante antilichamen specifiek voor het humane placentaire alkalische fosfatase

Veronique FeysWalther Fiers

Expression of human and murine interleukin-5 in eukaryotic systems

Jan TavernierRené DevosJosé Van der HeydenGuido HauquierRita BaudenIna FachéEric KawashimaJoël VandekerckhoveRoland ContrerasWalther Fiers

A1 Journal Article in DNA-A JOURNAL OF MOLECULAR & CELLULAR BIOLOGY

Four different interleukin-1 species sensitize to the lethal action of tumour necrosis factor

Bart EveraerdtPeter BrouckaertAlan ShawWalther Fiers

A1 Journal Article in BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Inflammatory properties of recombinant tumor necrosis factor in rabbit skin in vivo

M RampartW De SmetWalther FiersAG Herman

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

Lithium chloride potentiates tumor necrosis factor-mediated cytotoxicity in vitro and in vivo

Rudi BeyaertBart VanhaesebroeckPhilip SuffysFrans Van RoyWalther Fiers

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Onderzoek van de molekulair biologische werking van tumor nekrosis faktor

Philip SuffysWalther Fiers

Paradoxical effects of tumour necrosis factor in experimental ovarian cancer

STA MalikDB GriffinWalther FiersFR Balkwill

A1 Journal Article in INTERNATIONAL JOURNAL OF CANCER

Purification of human interleukin-4 produced in Escherichia coli

Bettadapura JayaramRené DevosYves GuisezWalther Fiers

A1 Journal Article in GENE

Recombinant influenza virus hemagglutinine : expressie, zuivering en immunologische karakterisatie

Geertrui MaertensWalther Fiers

Species specificity and involvement of other cytokines in endotoxic shock action of recombinant tumour necrosis factor in mice

Peter BrouckaertBart EveraerdtClaude LibertNozomi TakahashiWalther Fiers

A1 Journal Article in AGENTS AND ACTIONS

TNF in combination with interferon-γ is cytotoxic to normal, untransformed mouse and rat embryo fibroblast-like cells

Philip SuffysRudi BeyaertFrans Van RoyWalther Fiers

A1 Journal Article in ANTICANCER RESEARCH

Transformation of Aspergillus niger with the homologous nitrate reductase gene

SE UnklesEI CampbellDirk CarrezC GrieveRoland ContrerasWalther FiersCAMJJ Van den HondelJR Kinghorn

A1 Journal Article in GENE

Tumor necrosis factor-α induces the phosphorylation of 28kDa stress proteins in endothelial cells: possible role in protection against cytotoxicity?

Bernard RobayeAnne HepburnRaymond LecocqWalther FiersJean-Marie BoeynaemsJacques E Dumont

A1 Journal Article in BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Tumorigenicity, invasiveness and metastatic capability of FR3T3 rat cells before and after transfection with bovine papilloma virus type 1 DNA.

P COOPMANFrans Van RoyC DRAGONETTIJ GAOWalther FiersG MENEGUZZIMarcus Mareel

A1 Journal Article in CLINICAL & EXPERIMENTAL METASTASIS

1988

Autocrine secretion of tumor necrosis factor under the influence of interferon-γ amplifies HLA-DR gene induction in human monocytes

Fernando Arenzana-SeisdedosSøren C MogensenFrançoise VuillierWalther FiersJean-Louis Virelizier

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Combined treatment of colon adenocarcinoma in rats with tumor necrosis factor and the interferon inducer ABPP

Richard L MarquetAlexander MM EggermontRon WF de BruinWalther FiersJohannes Jeekel

A1 Journal Article in JOURNAL OF INTERFERON RESEARCH

Endocytic pathway of recombinant murine tumor necrosis factor in L-929 cells

R MosselmansA HepburnJE DumontWalther FiersP Galand

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Expression in non-lymphoid cells of mouse recombinant immunoglobulin directed against the tumour marker human placental alkaline phosphatase

Peter De WaeleVéronique FeysAndré Van De VoordeFrancis MolemansWalther Fiers

A1 Journal Article in EUROPEAN JOURNAL OF BIOCHEMISTRY

Expression of functional mouse antibodies directed against the tumour marker human placental alkaline phosphatase in non-lymphoid cells

Véronique FeysPeter De WaeleAndré Van de VoordeP CasneufWalther Fiers

A1 Journal Article in INTERNATIONAL JOURNAL OF CANCER

Genes for IFN-β-2 (IL-6), tumor necrosis factor, and IL-1 are expressed at high levels in the organs of normal individuals

Michael G ToveyJean ContentIon GresserJean GugenheimBrigitte BlanchardJacqueline GuymarhoPascale PoupartMichele GigouAlan ShawWalther Fiers

A1 Journal Article in JOURNAL OF IMMUNOLOGY

High-level transient expression of influenza virus proteins from a series of SV40 late and early replacement vectors

Danny HuylebroeckGeert MaertensMartine VerhoeyenClaude LopezAlex RaeymakersWilly Min JouWalther Fiers

A1 Journal Article in GENE

Induction of HLA class II antigens by IFN-gamma on K562 cells depends on the production of a specific inhibitor and on the acquisition of a differentiated phenotype

P KriefC BoucheixA VanagthovenC BillardWalther FiersC JasminB Azzarone

Interleukin 1α acts as an autocrine growth factor for RPMI1788, an Epstein-Barr virus-transformed human B cell line

Peter VandenabeeleBettadapura JayaramRené DevosAlan ShawWalther Fiers

A1 Journal Article in EUROPEAN JOURNAL OF IMMUNOLOGY

Involvement of a serine protease in tumour-necrosis-factor-mediated cytotoxicity

Philip SuffysRudi BeyaertFrans Van RoyWalther Fiers

A1 Journal Article in EUROPEAN JOURNAL OF BIOCHEMISTRY

Production of interferon γ by peripheral blood mononuclear cells from normal subjects and from patients with rheumatoid arthritis

A ReuterJ BernierY Vrindts GevaertR Meuleman GathyM MalaiseWalther FiersP Franchimont

A1 Journal Article in CLINICAL AND EXPERIMENTAL RHEUMATOLOGY

Rapid phosphorylation of a 27 kDa protein induced by tumor necrosis factor

Anne HepburnDominique DemolleJean-Marie BoeynaemsWalther FiersJacques E Dumont

A1 Journal Article in FEBS LETTERS

Slippage of DNA-polymerase-I during synthesis of ds-cDNA

René DevosJan TavernierWalther Fiers

A1 Journal Article in NUCLEIC ACIDS RESEARCH

Structure of tumour necrosis factor by X-ray solution scattering and preliminary studies by single crystal X-ray diffraction

Anita Lewit-BentleyRoger FourmeRichard KahnThierry PrangéPatrice VachetteJan TavernierGuido HauquierWalther Fiers

A1 Journal Article in JOURNAL OF MOLECULAR BIOLOGY

The antitumor function of tumor necrosis factor (TNF), 1: therapeutic action of TNF against an established murine sarcoma is indirect, immunologically dependent, and limited by severe toxicity

Edward A HavellWalther FiersRobert J North

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

Three distinct classes of regulatory cytokines control endothelial cell MHC antigen expression: interactions with immune γ interferon differentiate the effects of tumor necrosis factor and lymphotoxin from those of leukocyte α and fibroblast β interferons

Lynne A LapierreWalther FiersJordan S Pober

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

Tumor necrosis factor and interleukin 1 activate phospholipase in rat chondrocytes

Philip SuffysFrans Van RoyWalther Fiers

A1 Journal Article in FEBS LETTERS

Tumor necrosis factor increases the production of plasminogen activator inhibitor in human endothelial cells in vitro and in rats in vivo

Victor WM van HinsberghTeake KooistraEva A van den BergHans MG PrincenWalther FiersJef J Emeis

A1 Journal Article in BLOOD

Tumor necrosis factor α induces early morphologic and metabolic alterations in Friend leukemia cell tumors and fibrosarcomas in mice

E ProiettiF BelardelliG CarpinelliM Di VitoD WoodrowJ MossP SestiliWalther FiersI GresserF Podo

A1 Journal Article in INTERNATIONAL JOURNAL OF CANCER

Tumor-selective cytotoxic effects of murine tumor necrosis factor (TNF) and interferon-gamma (IFN-gamma) in organ culture of B16 melanoma cells and heart tissue.

Marcus MareelC DRAGONETTIJan TavernierWalther Fiers

A1 Journal Article in INTERNATIONAL JOURNAL OF CANCER

Two conserved tryptophan residues of tumor necrosis factor and lymphotoxin are not involved in the biological activity

Xaveer Van OstadeJan TavernierWalther Fiers

A1 Journal Article in FEBS LETTERS

1987

A broad-host-range expression vector based on the pL promoter of coliphage λ: regulated synthesis of human interleukin 2 in Erwinia and Serratia species

Ronny LeemansErik RemautWalther Fiers

A1 Journal Article in JOURNAL OF BACTERIOLOGY

Activation of cultured human endothelial cells by recombinant lymphotoxin: comparison with tumor necrosis factor and interleukin 1 species

Jordan S PoberLynne A LapierreAlan H StolpenTommy A BrockTimothy A SpringerWalther FiersMichael P BevilacquaDonna L MendrickMichael A Gimbrone

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Alloinduced suppression and cytotoxicity: two functions of a single cell

Geert Leroux-RoelsJohan GrootenWalther Fiers

A1 Journal Article in IMMUNOLOGY LETTERS

Anti-tumor activity of recombinant mouse tumor necrosis factor (TNF) on colon cancer in rats is promoted by recombinant rat interferon gamma; toxicity is reduced by indomethacin

RL MarquetJNM IjzermansRWF de BruinWalther FiersJ Jeekel

A1 Journal Article in INTERNATIONAL JOURNAL OF CANCER

B cell growth modulating and differentiating activity of recombinant human 26-kd protein (BSF-2, HuIFN-β2, HPGF)

P PoupartPeter VandenabeeleS CayphasJ Van SnickGuy HaegemanV KruysWalther FiersJ Content

A1 Journal Article in EMBO JOURNAL

DNA fragmentation and cytotoxicity caused by tumor necrosis factor is enhanced by interferon-γ

Gillian B DealtryM Stuart NaylorWalther FiersFrances R Balkwill

A1 Journal Article in EUROPEAN JOURNAL OF IMMUNOLOGY

Evidence for tumor necrosis factor cachectin production in cancer

Frances BalkwillFrances BurkeDenis TalbotJan TavernierRichard OsborneStuart NaylorHelga DurbinWalther Fiers

A1 Journal Article in LANCET

Expression in plants of the cloned satellite tobacco necrosis virus genome and of derived insertion mutants

John Van EmmeloPaul AmelootWalther Fiers

A1 Journal Article in VIROLOGY

Gene cloning and structure: function relationship of cytokines such as TNF and interleukins

Walther FiersRudi BeyaertPeter BrouckaertBart EveraerdtGuy HaegemanPhilip SuffysJan TavernierPeter VandenabeeleBart VanhaesebroeckXaveer Van Ostade et al.

A1 Journal Article in IMMUNOLOGY LETTERS

Induction and regulation of mRNA encoding 26-kDa protein in human cell lines treated with recombinant human tumor necrosis factor

P DefilippiP PoupartJan TavernierWalther FiersJ Content

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Induction of an activation antigen on postcapillary venular endothelium in human skin organ culture

Diana V MessadiJordan S PoberWalther FiersMichael A Jr GimbroneGeorge F Murphy

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Membrane interleukin 1 induction on human endothelial cells and dermal fibroblasts

Evelyn A Kurt-JonesWalther FiersJordan S Pober

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Modulation of expression of class II histocompatibility antigens by secretion of a cellular inhibitor in K562 leukemic cells

Patricia KriefClaude BoucheixChristian BillardZohar MishalAndreas van AgthovenWalther FiersBruno Azzarone

A1 Journal Article in EUROPEAN JOURNAL OF IMMUNOLOGY

Modulation of tumor necrosis factor-α cytotoxicity in L929 cells by bacterial toxins, hydrocortisone and inhibitors of arachidonic acid metabolism

Anne HepburnJean-Marie BoeynaemsWalther FiersJacques E Dumont

A1 Journal Article in BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Nuclear magnetic resonance analysis of tumor necrosis factor-induced alterations of phospholipid metabolites and pH in Friend leukemia cell tumors and fibrosarcomas in mice

Franca PodoGiulia CarpinelliMassimo Di VitoMassimo GianniniEnrico ProiettiWalther FiersIon GresserFilippo Belardelli

A1 Journal Article in CANCER RESEARCH

Pathology of tumours produced in syngeneic Fischer rats by fibroblast-like cells before and after transfections with oncogenes.

J GAOFrans Van RoyL MESSIAENJ COSAERTG LIEBAUTP COOPMANWalther FiersMarcus Mareel

A1 Journal Article in PATHOLOGY RESEARCH AND PRACTICE

Recombinant human tumour necrosis factor (rTNF)2 enhances leukotriene biosynthesis in neutrophils and eosinophils stimulated with the Ca2+ ionophore A23187

Régine RoubinPP ElsasWalther FiersAJ Dessein

A1 Journal Article in CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Recombinant interleukin-2 directly augments the cytotoxicity of human monocytes

Miroslav MalkovskýBruce LovelandMargaret NorthGeoffrey L AshersonLiquan GaoPeter WardWalther Fiers

A1 Journal Article in NATURE

Recombinant tumor necrosis factor can induce interleukin 2 receptor expression and cytolytic activity in a rat × mouse T cell hybrid

Geert PlaetinckWim DeclercqJan TavernierMarkus NabholzWalther Fiers

A1 Journal Article in EUROPEAN JOURNAL OF IMMUNOLOGY

Recombinant tumour necrosis factor inhibits malaria parasites in vivo but not in vitro

Janice TaverneJan TavernierWalther FiersJHL Playfair

A1 Journal Article in CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Reduced tumour necrosis factor-induced cytotoxicity by inhibitors of the arachidonic acid metabolism

Philip SuffysRudi BeyaertFrans Van RoyWalther Fiers

A1 Journal Article in BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Specific suppression elicited by EL4 lymphoma cells in syngeneic mice : specificity includes self-antigens on EL4

Johan GrootenGeert Leroux-RoelsWalther Fiers

A1 Journal Article in EUROPEAN JOURNAL OF IMMUNOLOGY

Structure-function relationship of tumor necrosis factor and its mechanism of action

Walther FiersPeter BrouckaertAlfred L GoldbergIsis C KettelhutPhilip SuffysJan TavernierBart VanhaesebroeckFrans Van Roy

A1 Journal Article in CIBA FOUNDATION SYMPOSIA

The 3' untranslated region of the human interferon-β mRNA has an inhibitory effect on translation

V KruysM WatheletP PoupartRoland ContrerasWalther FiersJ ContentG Huez

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The effect of recombinant human tumour necrosis factor on growth and macromolecular synthesis of human epithelial cells

GB DealtryMS NaylorWalther FiersFR Balkwill

A1 Journal Article in EXPERIMENTAL CELL RESEARCH

The toxic effects of tumor necrosis factor in vivo and their prevention by cyclooxygenase inhibitors

Isis C KettelhutWalther FiersAlfred L Goldenberg

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Therapeutic potential of tumor necrosis factor-α and γ-interferon in experimental human ovarian cancer

Frances R BalkwillBruce G WardElaine MoodieWalther Fiers

A1 Journal Article in CANCER RESEARCH

Toxic effects of recombinant tumor necrosis factor in suckling mice: comparisons with interferon α/β

Ion GresserDavid WoodrowJill MossChantal MauryJan TavernierWalther Fiers

A1 Journal Article in AMERICAN JOURNAL OF PATHOLOGY

Tumor necrosis factor: a potential antitumor agent?

Walther FiersRudi BeyaertPeter BrouckaertBart EveraerdtPhilip SuffysJan TavernierBart VanhaesebroeckFrans Van Roy

A1 Journal Article in JOURNAL OF INTERFERON RESEARCH

1986

Anti-tumor effects of interferon in mice injected with interferon-sensitive and interferon-resistant Friend leukemia cells, V : comparisons with the action of tumor necrosis factor

I GresserF BelardelliJan TavernierWalther FiersF PodoM FedericoG CarpinelliP DuvillardM PradeC Maury et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF CANCER

Cloning and structure of a mouse interleukin-2 chromosomal gene

Wim DegraveGuus SimonsRené DevosGeert PlaetinckErik RemautJan TavernierWalther Fiers

A1 Journal Article in MOLECULAR BIOLOGY REPORTS

Construction of stable laboratory and industrial yeast strains expressing a foreign gene by integrative transformation using a dominant selection system

JingDong ZhuRoland ContrerasWalther Fiers

A1 Journal Article in GENE

Expression of cell surface glycoproteins in tumour invasion in vitro

Marcus MareelC DragonettiR HoogheErik BruyneelMarc BrackeFrans Van RoyJ GaoGeorges De BruyneWalther Fiers

Genes for the tumor necrosis factors α and β are linked to the human major histocompatibility complex

Thomas SpiesCynthia C MortonSergei A NedospasovWalther FiersDonald PiousJack L Strominger

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetische manipulatie in de toekomst

Geert Leroux-RoelsWalther Fiers

A4 Journal Article in ANNALES COLLEGII MEDICI ANTVERPIENSIS

Growth inhibition and cytotoxicity of tumor necrosis factor in L929 cells is enhanced by high cell density and inhibition of mRNA synthesis

Martina KirsteinWalther FiersCorrado Baglioni

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Human tumor xenografts treated with recombinant human tumor necrosis factor alone or in combination with interferons

Frances R BalkwillAudrey LeeGary AldamElaine MoodieJ Alero ThomasJan TavernierWalther Fiers

A1 Journal Article in CANCER RESEARCH

In vivo anti-tumour activity of recombinant human and murine TNF, alone and in combination with murine IFN-γ, on a syngeneic murine melanoma

Peter BrouckaertGeert Leroux-RoelsYves GuisezJan TavernierWalther Fiers

A1 Journal Article in INTERNATIONAL JOURNAL OF CANCER

Induction of the synthesis of tumor necrosis factor receptors by interferon-γ

Vito RuggieroJan TavernierWalther FiersCorrado Baglioni

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Inefficient translation initiation causes premature transcription termination in the lacZ gene

Patrick StanssensErik RemautWalther Fiers

A1 Journal Article in CELL

Invasiveness and metastatic capability of rat fibroblast-like cells before and after transfection with immortalizing and transforming genes.

Frans Van RoyLudwine MessiaenGilberte LiebautJin GaoChristian H DragonettiWalther FiersMarcus Mareel

A1 Journal Article in CANCER RESEARCH

Natural killer cell response to interferons

Mario Abbud-FilhoBernard J RansilVicki E KelleyWalther FiersTerry B Strom

A1 Journal Article in CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY

Overlapping patterns of activation of human endothelial cells by interleukin 1, tumor necrosis factor, and immune interferon

Jordan S PoberMichael A GimbroneLynne A LapierreDonna L MendrickWalther FiersRobert RothleinTimothy A Springer

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Purification, crystallization and preliminary X-ray data of the bacteriophage MS2

Karin ValegårdTorsten UngeIréne MonteliusBror StrandbergWalther Fiers

A1 Journal Article in JOURNAL OF MOLECULAR BIOLOGY

Recombinant human tumor necrosis factor increases mRNA levels and surface expression of HLA-A, B antigens in vascular endothelial cells and dermal fibroblasts in vitro

Tucker CollinsLynne A LapierreWalther FiersJack L StromingerJordan S Pober

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Recombinant tumor necrosis factor and immune interferon act singly and in combination to reorganize human vascular endothelial cell monolayers

Alan H StolpenEva C GuinanWalther FiersJordan S Pober

A1 Journal Article in AMERICAN JOURNAL OF PATHOLOGY

Recombinant tumor necrosis factor induces procoagulant activity in cultured human vascular endothelium: characterization and comparison with the actions of interleukin 1

Michael P BevilacquaJordan S PoberGerard R MajeauWalther FiersRamzi S CotranMichael A Jr Gimbrone

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Recombinant tumor necrosis factor: Species specificity for a variety of human and murine transformed cell lines

Lucie FransenMarie-Rose RuysschaertJosé Van der HeydenWalther Fiers

A1 Journal Article in CELLULAR IMMUNOLOGY

Recombinant tumor necrosis factor: its effect and its synergism with interferon-γ on a variety of normal and transformed human cell lines

Lucie FransenJosé Van der HeydenRoos RuysschaertWalther Fiers

A1 Journal Article in EUROPEAN JOURNAL OF CANCER & CLINICAL ONCOLOGY

Species specificity of human and murine tumor necrosis factor: a comparative study of tumor necrosis factor receptors

Richard A SmithMartina KirsteinWalther FiersCorrado Baglioni

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Structural analysis of the sequence coding for an inducible 26-kDa protein in human fibroblasts

Guy HaegemanJean ContentGuido VolckaertRik DerynckJan TavernierWalther Fiers

A1 Journal Article in EUROPEAN JOURNAL OF BIOCHEMISTRY

Structural studies of the carbohydrate chains of human y-interferon

Johanna HGM MutsaersJohannis P KamerlingRené DevosYves GuisezWalther FiersJohannes FG Vliegenthart

A1 Journal Article in EUROPEAN JOURNAL OF BIOCHEMISTRY

Synthesis and maturation of recombinant human tumor necrosis factor in eukaryotic systems

Rita MüllerAnne MarmenoutWalther Fiers

A1 Journal Article in FEBS LETTERS

Treatment of murine interferon-α/β-sensitive and -resistant Friend leukemia cells with tumor necrosis factor in combination with murine interferon-α/β or -γ

José Van der HeydenLucie FransenWalther Fiers

A1 Journal Article in JOURNAL OF INTERFERON RESEARCH

Two distinct monokines, interleukin 1 and tumor necrosis factor, each independently induce biosynthesis and transient expression of the same antigen on the surface of cultured human vascular endothelial cells

Jordan S PoberMichael P BevilacquaDonna L MendrickLynne A LapierreWalther FiersMichael A Gimbrone

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Two monokines, interleukin 1 and tumor necrosis factor, render cultured vascular endothelial cells susceptible to lysis by antibodies circulating during Kawasaki syndrome

Donald YM LeungRaif S GehaJane W NewburgerJane C BurnsWalther FiersLynne A LapierreJordan S Pober

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

Use of the phage lambda PL promoter for high-level expression of human interferons in Escherichia coli

Erik RemautPatrick StanssensGuus SimonsWalther Fiers

A1 Journal Article in METHODS IN ENZYMOLOGY

1985

A method for fast and pure DNA elution from agarose gels by centrifugal filtration

JingDong ZhuWalter KempenaersDominique Van Der StraetenRoland ContrerasWalther Fiers

A1 Journal Article in BIO-TECHNOLOGY

Alterations upstream from the Shine-Dalgarno region and their effect on bacterial gene expression

Patrick StanssensErik RemautWalther Fiers

A1 Journal Article in GENE

Binding of human tumor necrosis factor to high-affinity receptors on HeLa and lymphoblastoid cells sensitive to growth inhibition

Corrado BaglioniSarah McCandlessJan TavernierWalther Fiers

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Defective IFN-γ production in the human neonate, II: role of increased sensitivity to the suppressive effects of prostaglandin E

Naomi WakasugiJean-Louis VirelizierFernando Arenzana-SeisdedosBernhard RothhutJean-Michel Mencia HuertaFrançoise Russo-MarieWalther Fiers

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Human dermal fibroblasts present tetanus toxoid antigen to antigen-specific T cell clones

Dale T UmetsuJordan S PoberHaifa H JabaraWalther FiersEdmond J YunisSteven J BurakoffCarol S ReissRaif S Geha

A1 Journal Article in JOURNAL OF CLINICAL INVESTIGATION

Interferon-γ is a strong modulator of NK susceptibility and expression of β2-microglobulin but not of transferrin receptors of K562 cells

Alvar GrönbergRolf KiesslingWalther Fiers

A1 Journal Article in CELLULAR IMMUNOLOGY

Interferons as macrophage-activating factors, III: preferential effects of interferon-γ on the interleukin 1 secretory potential of fresh or aged human monocytes

Fernando Arenzana-SeisdedosJean Louis VirelizierWalther Fiers

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Molecular cloning and expression of human tumor necrosis factor and comparison with mouse tumor necrosis factor

Anne MarmenoutLucie FransenJan TavernierJosé Van der HeydenRichard TizardEric KawashimaAlan ShawMerrie-Jo JohnsonDominique SemonRita Müller et al.

A1 Journal Article in EUROPEAN JOURNAL OF BIOCHEMISTRY

Molecular cloning of mouse tumour necrosis factor cDNA and its eukaryotic expression

Lucie FransenRita MüllerAnne MarmenoutJan TavernierJosé Van der HeydenEric KawashimaAndré CholletRichard TizardHugo Van HeuverswynAdri Van Vliet et al.

A1 Journal Article in NUCLEIC ACIDS RESEARCH

Recombinant interleukin 2 induces immunoglobulin secretion in Staphylococcus aureus cowan strain I activated human B-cells

René DevosBettadapura JayaramPeter VandenabeeleWalther Fiers

A1 Journal Article in IMMUNOLOGY LETTERS

Screening of sera and tumor extracts of cancer patients using a monoclonal antibody directed against human placental alkaline phosphatase

André Van de VoordeGuy De GrootePeter De WaeleMark E DebroeDirk PolletJozef DeboeverDirk VandekerckhoveWalther Fiers

A1 Journal Article in EUROPEAN JOURNAL OF CANCER & CLINICAL ONCOLOGY

1984

Characterization of soluble factors that induce the cytolytic activity and the expression of T cell growth factor receptors of a T cell hybrid

François ErardPatricia CorthesyKendall A SmithWalther FiersAndreas ConzelmannMarkus Nabholz

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

Circulating interferon in rabbits after simultaneous intramuscular administration of human alpha and gamma interferons

K CantellWalther FiersS HirvonenL Pyhälä

A1 Journal Article in JOURNAL OF INTERFERON RESEARCH

Cloned human interferon-γ, but not interferon-β or -α, induces expression of HLA-DR determinants by fetal monocytes and myeloid leukemic cell lines

Vicki E KelleyWalther FiersTerry B Strom

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Controlled synthesis of the coat protein of satellite tobacco necrosis virus in Escherichia coli

John Van EmmeloPaul AmelootGeert PlaetinckWalther Fiers

A1 Journal Article in VIROLOGY

High-level expression of human interferon gamma in Escherichia coli under control of the pL promoter of bacteriophage lambda

Guus SimonsErik RemautBernard AlletRené DevosWalther Fiers

A1 Journal Article in GENE

Human cytolytic T lymphocyte interactions with vascular endothelium and fibroblasts: role of effector and target cell molecules

Tucker CollinsAlan M KrenskyCarol ClaybergerWalther FiersMichael A Jr GimbroneSteven J BurakoffJordan S Pober

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Immune interferon activates multiple class II major histocompatibility complex genes and the associated invariant chain gene in human endothelial cells and dermal fibroblasts

Tucker CollinsAlan J KormanClaire T WakeJeremy M BossDietmar J KappesWalther FiersKenneth A AultMichael A Jr GimbroneJack L StromingerJordan S Pober

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Induction of cytolytic cells by pure recombinant human interleukin 2

René DevosGeert PlaetinckWalther Fiers

A1 Journal Article in EUROPEAN JOURNAL OF IMMUNOLOGY

Karakterisering van energiemetabolisme en receptoren voor neurotransmitters in hersencellen in vitro : farmacologische toepassingsmogelijkheden

Petrus Johan PauwelsWalther FiersA. Trouet

Oligonucleotide directed mutagenesis : selection of mutants by hemimethylation of GATC-sequences

Anne MarmenoutErik RemautJacques van BoomWalther Fiers

A1 Journal Article in MOLECULAR & GENERAL GENETICS

Protein kinase activities in immune complexes of Simian Virus 40 large T-antigen and transformation-associated cellular p53 protein

Frans Van RoyLucie FransenWalther Fiers

A1 Journal Article in MOLECULAR AND CELLULAR BIOLOGY

Purification of recombinant glycosylated human gamma interferon expressed in transformed Chinese hamster ovary cells

René DevosChris OpsomerShaun J ScahillJosé Van der HeydenWalther Fiers

A1 Journal Article in JOURNAL OF INTERFERON RESEARCH

The presence of homologous regions between interferon sequences

Jan TavernierWalther Fiers

A1 Journal Article in CARLSBERG RESEARCH COMMUNICATIONS

1983

Changes in gene expression and protein phosphorylation in murine cells, transformed or abortively infected with wild type and mutant Simian Virus 40

Lucie FransenFrans Van RoyWalther Fiers

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Cloning and structure of the human interleukin 2 chromosomal gene

Wim DegraveJan TavernierFred DuerinckGeert PlaetinckRené DevosWalther Fiers

A1 Journal Article in EMBO JOURNAL

Codon usage and mistranslation : in vivo basal level misreading of the MS2 coat protein message

Jack ParkerTimothy C JohnstonPeter T BorgiaGreg HoltzErik RemautWalther Fiers

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Complete nucleotide sequence of the influenza B/Singapore/222/79 virus hemagglutinin gene and comparison with the B/Lee/40 Hemagglutinin

Martine VerhoeyenLudo Van RompuyWilly Min JouDanny HuylebroeckWalther Fiers

A1 Journal Article in NUCLEIC ACIDS RESEARCH

Deletion mapping of the inducible promoter of human IFN-β gene

Jan TavernierDirk GheysenFred DuerinckJosé Van der HeydenWalther Fiers

A1 Journal Article in NATURE

Expression and characterization of the product of a human immune interferon cDNA gene in Chinese-hamster ovary cells

Shaun J ScahillRené DevosJosé Van der HeydenWalther Fiers

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human fibroblast interferon RNA transcripts of different sizes in poly(I).poly(C) induced cells

Jean ContentLucas De WitJan TavernierWalther Fiers

A1 Journal Article in NUCLEIC ACIDS RESEARCH

Ia expression by vascular endothelium is inducible by activated T cells and by human γ interferon

JS PoberMA Jr GimbroneRS CotranCS ReissSJ BurakoffWalther FiersKA Ault

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

Improved localization of phosphorylation sites in simian virus 40 large T antigen

Frans Van RoyLucie FransenWalther Fiers

A1 Journal Article in JOURNAL OF VIROLOGY

Improved plasmid vectors with a thermoinducible expression and temperature-regulated runaway replication

Erik RemautHsu TsaoWalther Fiers

A1 Journal Article in GENE

Inducible high level synthesis of mature human fibroblast interferon in Escherichia coli

Erik RemautPatrick StanssensWalther Fiers

A1 Journal Article in NUCLEIC ACIDS RESEARCH

Lymphocytes recognize human vascular endothelial and dermal fibroblast Ia antigens induced by recombinant immune interferon

Jordan S PoberTucker CollinsMichael A Jr GimbroneRamzi S CotranJonathan D GitlinWalther FiersCarol ClaybergerAlan M KrenskySteven J BurakoffCarol S Reiss

A1 Journal Article in NATURE

Metabolic turnover of phosphorylation sites in simian virus 40 large T antigen

Frans Van RoyLucie FransenWalther Fiers

A1 Journal Article in JOURNAL OF VIROLOGY

Molecular cloning of human interleukin 2 cDNA and its expression in E. coli

René DevosGeert PlaetinckHilde CheroutreGuus SimonsWim DegraveJan TavernierErik RemautWalther Fiers

A1 Journal Article in NUCLEIC ACIDS RESEARCH

Molecular variation of influenza surface antigens

Ludo Van RompuyWilly Min JouMartine VerhoeyenDanny HuylebroeckWalther Fiers

A1 Journal Article in TRENDS IN BIOCHEMICAL SCIENCES

Simian virus 40 mutants carrying extensive deletions in the 72-base-pair repeat region

Dirk GheysenAndré Van De VoordeRoland ContrerasJosé Van der HeydenFred DuerinckWalther Fiers

A1 Journal Article in JOURNAL OF VIROLOGY

Studie van de moleculaire vormen van dopamine ß-hydroxylase bij het neuroblastoom

Norbert FraeymanWalther FiersA De Schaepdryver

Use of monoclonal antibodies to detect human placental alkaline phosphatase

Guy De GrootePeter De WaeleAndré Van de VoordeMark De BroeWalther Fiers

A1 Journal Article in CLINICAL CHEMISTRY

1982

Cloning and structure of the human immune interferon-γ chromosomal gene

Yoichi TayaRené DevosJan TavernierHilde CheroutreGilbert EnglerWalther Fiers

A1 Journal Article in EMBO JOURNAL

Complete nucleotide sequence of a human influenza neuraminidase gene of subtype N2 (A/Victoria/3/75)

Ludo Van RompuyWilly Min JouDanny HuylebroeckWalther Fiers

A1 Journal Article in JOURNAL OF MOLECULAR BIOLOGY

Evidence for the direct involvement of DNA replication origin in synthesis of late SV40 RNA

Roland ContrerasDirk GheysenJ KnowlandAndré Van de VoordeWalther Fiers

A1 Journal Article in NATURE

Functional expression of individual plasmid-coded RNA bacteriophage MS2 genes

Erik RemautPeter De WaeleAnne MarmenoutPatrick StanssensWalther Fiers

A1 Journal Article in EMBO JOURNAL

High-level synthesis in Escherichia coli of the SV40 small-t antigen under control of the bacteriophage lambda pL promoter

Catherine DeromDirk GheysenWalther Fiers

A1 Journal Article in GENE

In vitro cotranslational processing of human pre-interferon β1 enhances its biological activity

Jean ContentL De WitRik DerynckE De ClercqWalther Fiers

A1 Journal Article in VIROLOGY

Isolation and characterization of IFN-gamma mRNA derived from mitogen-induced human splenocytes

René DevosHilde CheroutreYoichi TayaWalther Fiers

A1 Journal Article in JOURNAL OF INTERFERON RESEARCH

Lysis gene expression of RNA phage MS2 depends on a frameshift during translation of the overlapping coat protein gene

RA KasteleinErik RemautWalther FiersJ Van Duin

A1 Journal Article in NATURE

Molecular cloning of human immune interferon cDNA and its expression in eukaryotic cells

René DevosHilde CheroutreYoichi TayaWim DegraveHugo Van HeuverswynWalther Fiers

A1 Journal Article in NUCLEIC ACIDS RESEARCH

Preferential codon usage in prokaryotic genes: the optimal codon-anticodon interaction energy and the selective codon usage in efficiently expressed genes

Henri GrosjeanWalther Fiers

A1 Journal Article in GENE

Secretory proteins induced in human fibroblasts under conditions used for the production of interferon β

Jean ContentLucas De WitDenis PierardRik DerynckErik De ClercqWalther Fiers

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Simple, efficient in vitro synthesis of capped RNA useful for direct expression of cloned eukaryotic genes

Roland ContrerasHilde CheroutreWim DegraveWalther Fiers

A1 Journal Article in NUCLEIC ACIDS RESEARCH

Systematic alteration of the nucleotide sequence preceding the translation initiation codon and the effects on bacterial expression of the cloned SV40 small-t antigen gene

Dirk GheysenDirk IserentantCatherine DeromWalther Fiers

A1 Journal Article in GENE

The human fibroblast and human immune interferon genes and their expression in homologous and heterologous cells

Walther FiersErik RemautRené DevosHilde CheroutreRoland ContrerasDirk GheysenWim DegravePatrick StanssensJan TavernierYoichi Taya et al.

A1 Journal Article in PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES

The sequence specificity of endonucleases CauI and CauII isolated from Chloroflexus aurantiacus

Francis MolemansJohn Van EmmeloWalther Fiers

A1 Journal Article in GENE

1981

A simple apparatus for injection of nanoliter quantities into Xenopus laevis oocytes

Roland ContrerasHilde CheroutreWalther Fiers

A1 Journal Article in ANALYTICAL BIOCHEMISTRY

Complete nucleotide sequence of the nucleoprotein gene from the human influenza strain A/PR/8/34 (HON1)

Ludo Van RompuyWilly Min JouDanny HuylebroeckRené DevosWalther Fiers

A1 Journal Article in EUROPEAN JOURNAL OF BIOCHEMISTRY

Complete structure of A/duck/Ukraine/63 influenza hemagglutinin gene: animal virus as progenitor of human H3 Hong Kong 1968 influenza hemagglutinin

Rongxiang FangWilly Min JouDanny HuylebroeckRené DevosWalther Fiers

A1 Journal Article in CELL

Evidence for a unique human fibroblast interferon (IFN-β1) chromosomal gene, devoid of intervening sequences

Jan TavernierRik DerynckWalther Fiers

A1 Journal Article in NUCLEIC ACIDS RESEARCH

Initiation of transcription by RNA polymerase II in permeable, SV40-infected or noninfected, CV1 cells : evidence for multiple promoters of SV40 late transcription

Roland ContrerasWalther Fiers

A1 Journal Article in NUCLEIC ACIDS RESEARCH

Molecular mechanisms of nucleotide-sequence rearrangements in cDNA clones of human fibroblast interferon mRNA

Guido VolckaertJan TavernierRik DerynckRené DevosWalther Fiers

A1 Journal Article in GENE

Nucleotide sequence of the chromosomal gene for human fibroblast (β1) interferon and of the flanking regions

Wim DegraveRik DerynckJan TavernierGuy HaegemanWalther Fiers

A1 Journal Article in GENE

Phosphorylation patterns of tumour antigens in cells lytically infected or transformed by simian virus 40

Frans Van RoyLucie FransenWalther Fiers

A1 Journal Article in JOURNAL OF VIROLOGY

Plasmid vectors for high-efficiency expression controlled by the PL promoter of coliphage lambda

Erik RemautPatrick StanssensWalther Fiers

A1 Journal Article in GENE

Role of the signal peptide in the trans-membrane transport of PBR322 coded β-lactamase

Anne MarmenoutErik RemautWalther Fiers

Specific binding of eukaryotic initiation factor 2 to satellite tobacco necrosis virus RNA at a 5'-terminal sequence comprising the ribosome binding site

Raymond KaempferJohn Van EmmeloWalther Fiers

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The β-lactamase gene of PBR322 is transcribed from two different promoters

Patrick StanssensErik RemautWalther Fiers

1980

Antigenic drift between the haemagglutinin of the Hong Kong influenza strains A/Aichi/2/68 and A/Victoria/3/75

Martine VerhoeyenRongxiang FangWilly Min JouRené DevosDanny HuylebroeckEric SamanWalther Fiers

A1 Journal Article in NATURE

Characterization of the 5'-terminal cap structures of early simian virus 40 mRNA

Guy HaegemanWalther Fiers

A1 Journal Article in JOURNAL OF VIROLOGY

Complete structure of the hemagglutinin gene from the human influenza A/Victoria/3/75 (H3N2) strain as determined from cloned DNA

Willy Min JouMartine VerhoeyenRené DevosEric SamanRongxiang FangDanny HuylebroeckWalther FiersGeoffrey ThrelfallChristine BarberNorman Carey et al.

A1 Journal Article in CELL

Construction and characterization of a plasmid containing a nearly full-size DNA copy of satellite tobacco necrosis virus RNA

John Van EmmeloRené DevosMark YsebaertWalther Fiers

A1 Journal Article in JOURNAL OF MOLECULAR BIOLOGY

Expression of human fibroblast interferon gene in Escherichia coli

Rik DerynckErik RemautErik SamanPatrick StanssensErik De ClercqJean ContentWalther Fiers

A1 Journal Article in NATURE

Isolation and structure of a human fibroblast interferon gene

Rik DerynckJean ContentErik De ClercqGuido VolckaertJan TavernierRené DevosWalther Fiers

A1 Journal Article in NATURE

Nucleotide sequence of Simian Virus 40 DNA: structure of the middle segment of the HindII+III restriction fragment B (sixth part of the T antigen gene) and codon usage

Hugo Van HeuverswynAndré Van De VoordeJacqueline Van HerrewegheGuido VolckaertPaul De WinneWalther Fiers

A1 Journal Article in EUROPEAN JOURNAL OF BIOCHEMISTRY

Nucleotide sequence of the Hind-I-proximal part of Simian Virus 40 HindII+III restriction fragment B (fifth part of the T antigen gene)

Jacqueline Van HerrewegheAndré Van De VoordeWalther Fiers

A1 Journal Article in EUROPEAN JOURNAL OF BIOCHEMISTRY

Nucleotide sequence of the Simian Virus 40 HindII+III restriction fragment A (second part of the T antigen gene)

Guido VolckaertAndré Van De VoordeWalther Fiers

A1 Journal Article in EUROPEAN JOURNAL OF BIOCHEMISTRY

Nucleotide sequence of the Simian Virus 40 HindII+III restriction fragment I (fourth part of the T antigen gene)

Jacqueline Van HerrewegheAndré Van De VoordeWalther Fiers

A1 Journal Article in EUROPEAN JOURNAL OF BIOCHEMISTRY

Recognition sequence for the restriction endonuclease BglI from Bacillus globigii

Hugo Van HeuverswynWalther Fiers

A1 Journal Article in GENE

Secondary structure of mRNA and efficiency of translation initiation

Dirk IserentantWalther Fiers

A1 Journal Article in GENE

Studies on the bacteriophage MS2, XLI: nature of the azure mutation

Dirk IserentantMarc Van MontaguWalther Fiers

A1 Journal Article in JOURNAL OF MOLECULAR BIOLOGY

Total nucleotide sequence of a nearly full-size DNA copy of satellite tobacco necrosis virus RNA

Marc YsebaertJohn Van EmmeloWalther Fiers

A1 Journal Article in JOURNAL OF MOLECULAR BIOLOGY

1979

3′-Terminal nucleotide sequence (N = 41) of satellite tobacco necrosis virus RNA

Jozef MerregaertJohn Van EmmeloWalther Fiers

A1 Journal Article in VIROLOGY

Asymmetric linker molecules for recombinant DNA constructions

Kjeld E NorrisDirk IserentantRoland ContrerasWalther Fiers

A1 Journal Article in GENE

Characterization of the major altered leader sequence of late mRNA induced by SV40 deletion mutant d1-1811

Guy HaegemanDirk IserentantDirk GheysenWalther Fiers

A1 Journal Article in NUCLEIC ACIDS RESEARCH

Construction and characterization of a plasmid containing a nearly full-size DNA copy of bacteriophage MS2 RNA

René DevosJohn Van EmmeloRoland ContrerasWalther Fiers

A1 Journal Article in JOURNAL OF MOLECULAR BIOLOGY

Crystallization of bacteriophage MS2

Willy Min JouAlex RaeymaekersWalther Fiers

A1 Journal Article in EUROPEAN JOURNAL OF BIOCHEMISTRY

Heterogeneity of the 5' terminus of late mRNA induced by a viable simian virus 40 deletion mutant

Guy HaegemanHugo Van HeuverswynDirk GheysenWalther Fiers

A1 Journal Article in JOURNAL OF VIROLOGY

Identification of the translocatable element IS1 in a molecular chimera constructed with plasmid pBR322 DNA into which a bacteriophage MS2 DNA copy was inserted by the poly(dA)·Poly(dT) linker method

René DevosRoland ContrerasJohn Van EmmeloWalther Fiers

A1 Journal Article in JOURNAL OF MOLECULAR BIOLOGY

Isolation and characterization of a specific deletion mutant of human adenovirus type 2

Frans Van RoyGilbert EnglerWalther Fiers

A1 Journal Article in VIROLOGY

Nucleotide sequence analysis of two simian virus 40 mutants with deletions in the late region of the genome

Roland ContrerasCharles ColePaul BergWalther Fiers

A1 Journal Article in JOURNAL OF VIROLOGY

Nucleotide sequence analysis of two simian virus 40 mutants with deletions in the region coding for the carboxyl terminus of the T antigen

Hugo Van HeuverswynCharles ColePaul BergWalther Fiers

A1 Journal Article in JOURNAL OF VIROLOGY

Nucleotide sequence deletions within the coding region for small-t antigen of simian virus 40

Guido VolckaertJean FeunteunLionel V CrawfordPaul BergWalther Fiers

A1 Journal Article in JOURNAL OF VIROLOGY

Nucleotide sequence of the Hind-C fragment of Simian Virus 40 DNA: comparison of the 5'-untranslated region of wild-type virus and of some deletion mutants

Hugo Van HeuverswynWalther Fiers

A1 Journal Article in EUROPEAN JOURNAL OF BIOCHEMISTRY

Walther FiersH Grosjean

A1 Journal Article in NATURE

Secondary structure of the 5' end of bacteriophage MS2 RNA: methoxyamine and kethoxal modification

Dirk IserentantWalther Fiers

A1 Journal Article in EUROPEAN JOURNAL OF BIOCHEMISTRY

1978

Bacteriophage MS2 RNA: a correlation between the stability of the codon-anticodon interaction and the choice of code words

Henri GrosjeanDavid SankoffWilly Min JouWalther FiersRJ Cedergren

A1 Journal Article in JOURNAL OF MOLECULAR EVOLUTION

Characterization of the 5'-terminal capped structures of late simian virus 40-specific mRNA

Guy HaegemanWalther Fiers

A1 Journal Article in JOURNAL OF VIROLOGY

Complete nucleotide sequence of SV40 DNA

Walther FiersRoland ContrerasGuy HaegemanRaphaël RogiersAndré Van De VoordeHugo Van HeuverswynJacqueline Van HerrewegheGuido VolckaertMarc Ysebaert

A1 Journal Article in NATURE

Complete nucleotide sequence of the Simian-Virus 40 Hind-G fragment and localisation of the carboxyl terminus of the VP1 protein

Hugo Van HeuverswynAndré Van De VoordeWalther Fiers

A1 Journal Article in EUROPEAN JOURNAL OF BIOCHEMISTRY

Evidence for 'splicing' of SV40 16S mRNA

Guy HaegemanWalther Fiers

A1 Journal Article in NATURE

Interference with simian virus 40 DNA replication by adenovirus type 2 during mixed infection of monkey cells

Frans Van RoyWalther Fiers

A1 Journal Article in JOURNAL OF VIROLOGY

Localization of 5' terminus of late SV40 mRNA

Guy HaegemanWalther Fiers

A1 Journal Article in NUCLEIC ACIDS RESEARCH

Nucleotide sequence of part of the Simian Virus 40 Hind-D restriction fragment: the presumed initiation region of the VP2 gene

Marc YsebaertHugo Van HeuverswynAndré Van De VoordeWalther Fiers

A1 Journal Article in EUROPEAN JOURNAL OF BIOCHEMISTRY

Nucleotide sequence of the Simian Virus 40 Hind II+III restriction fragment J and the total amino acid sequence of the major structural protein VP1

Hugo Van HeuverswynAndré Van De VoordeWalther Fiers

A1 Journal Article in EUROPEAN JOURNAL OF BIOCHEMISTRY

Nucleotide sequence of the Simian Virus 40 Hind-K restriction fragment

Raphaël RogiersAndré Van De VoordeElichi SoedaWalther Fiers

A1 Journal Article in EUROPEAN JOURNAL OF BIOCHEMISTRY

Nucleotide sequence of the Simian Virus 40 HindII+III restriction fragment D and the total amino acid sequence of the late proteins VP2 and VP3

Marc YsebaertAndré Van De VoordeWalther Fiers

A1 Journal Article in EUROPEAN JOURNAL OF BIOCHEMISTRY

Nucleotide sequence of the Simian Virus 40 small-T gene

Guido VolckaertAndré Van De VoordeWalther Fiers

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nucleotide sequence of the Simian-Virus-40 DNA region coding for the carboxyl-terminal part of the T antigen

Hugo Van HeuverswynAndré Van De VoordeWalther Fiers

A1 Journal Article in EUROPEAN JOURNAL OF BIOCHEMISTRY

Nucleotide sequence of the restriction fragment Hind-F-EcoRI1 of Simian-Virus-40 DNA (part of the VP1 gene)

Roland ContrerasAndré Van De VoordeWalther Fiers

A1 Journal Article in EUROPEAN JOURNAL OF BIOCHEMISTRY

Sequence of 129 nucleotides at the 3'-terminus of encephalomyocarditis virus RNA

Alan G PorterJozef MerregaertJohn Van EmmeloWalther Fiers

A1 Journal Article in EUROPEAN JOURNAL OF BIOCHEMISTRY

Structure of the components of the adenovirus-simian virus 40 hybrid population Ad2++HEY and reciprocal molecular interactions

Frans Van RoyWalther Fiers

A1 Journal Article in JOURNAL OF MOLECULAR BIOLOGY

The 3'-terminal nucleotide sequence of encephalomyocarditis virus RNA

Jozef MerregaertJohn Van EmmeloRené DevosAlan PorterPeter FellnerWalther Fiers

A1 Journal Article in EUROPEAN JOURNAL OF BIOCHEMISTRY

1977

A micromethod for base analysis of 32P-labeled oligoribonucleotides

Guido VolckaertWalther Fiers

A1 Journal Article in ANALYTICAL BIOCHEMISTRY

A two-dimensional electrophoretic procedure for the separation of DNA restriction fragments

Rik DerynckWalther Fiers

A1 Journal Article in JOURNAL OF MOLECULAR BIOLOGY

Micro thin-layer techniques for rapid sequence analysis of 32P-labeled RNA : double digestion and pancreatic ribonuclease analyses

Guido VolckaertWalther Fiers

A1 Journal Article in ANALYTICAL BIOCHEMISTRY

Mycoplasma in African green monkey kidney cell cultures : biochemical detection and effects in virus infected cells

Frans Van RoyWalther Fiers

A1 Journal Article in IN VITRO-JOURNAL OF THE TISSUE CULTURE ASSOCIATION

Nucleotide sequence of simian virus 40 Hind H restriction fragment

Guido VolckaertRoland ContrerasE SoedaAndré Van de VoordeWalther Fiers

A1 Journal Article in JOURNAL OF MOLECULAR BIOLOGY

Nucleotide sequence of the SV40 DNA restriction fragment Hind C-Hap 2

Hugo Van HeuverswynAndré Van De VoordeWalther Fiers

A1 Journal Article in NUCLEIC ACIDS RESEARCH

Nucleotide sequence of the restriction fragment Hind F-Eco RI2 of SV40 DNA

Roland ContrerasGuido VolckaertF ThysAndré Van de VoordeWalther Fiers

A1 Journal Article in NUCLEIC ACIDS RESEARCH

Overlapping of the VP2-VP3 gene and the VP1 gene in the SV40 genome

Roland ContrerasRaphaël RogiersAndré Van de VoordeWalther Fiers

A1 Journal Article in CELL

Synthesis by avian-myeloblastosis-virus RNA-dependent DNA polymerase of discrete reverse transcripts of bacteriophage RNA polyadenylated in vitro

René DevosJohn Van EmmeloPaul CelenElie GillisWalther Fiers

A1 Journal Article in EUROPEAN JOURNAL OF BIOCHEMISTRY

1976

Addition by ATP:RNA adenylyltransferase from Escherichia coli of 3'-linked oligo(A) to bacteriophage Qβ RNA and its effect on RNA replication

René DevosJohn Van EmmeloChris Seurinck-OpsomerElie GillisWalther Fiers

A1 Journal Article in BIOCHIMICA ET BIOPHYSICA ACTA

Analysis of 32P-labeled bacteriophage MS2 RNA by a mini-fingerprinting procedure

Guido VolckaertWilly Min JouWalther Fiers

A1 Journal Article in ANALYTICAL BIOCHEMISTRY

Cleavage map of the Simian-Virus-40 genome by the restriction endonuclease III of Haemophilus aegyptius

Robert Che-An YangAndré Van De VoordeWalther Fiers

A1 Journal Article in EUROPEAN JOURNAL OF BIOCHEMISTRY

Complete nucleotide sequence of bacteriophage MS2 RNA: primary and secondary structure of the replicase gene

Walther FiersRoland ContrerasFred DuerinckGuy HaegemanDirk IserentantJozef MerregaertWilly Min JouFrancis MolemansAlex RaeymaekersA Van den Berghe et al.

A1 Journal Article in NATURE

Nucleotide sequence of the restriction fragments Hind L and Hind M of SV40 DNA

Marc YsebaertF ThysAndré Van de VoordeWalther Fiers

A1 Journal Article in NUCLEIC ACIDS RESEARCH

On the possible modulating role of the isoleucine AUA-codon in bacteriophage MS2 RNA

Willy Min JouMarc Van MontaguWalther Fiers

A1 Journal Article in BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Rhythmic variations in purine run frequencies in bacteriophage RNA

RA EltonWalther Fiers

A1 Journal Article in JOURNAL OF THEORETICAL BIOLOGY

Sequence determination of Gp-rich oligonucleotides by means of the kethoxal modification

Willy Min JouWalther Fiers

A1 Journal Article in FEBS LETTERS

Specific cleavage and physical mapping of Simian-Virus-40 DNA by the restriction endonuclease of Arthrobacter luteus

Robert Che-An YangAndré Van De VoordeWalther Fiers

A1 Journal Article in EUROPEAN JOURNAL OF BIOCHEMISTRY

Studies on the bacteriophage MS2, XXXIII: comparison of the nucleotide sequences in related bacteriophage RNAs

Willy Min JouWalther Fiers

A1 Journal Article in JOURNAL OF MOLECULAR BIOLOGY

The enzymic addition of poly(A) to the 3'-end of RNA using bacteriophage MS2 RNA as a model system

René DevosElie GillisWalther Fiers

A1 Journal Article in EUROPEAN JOURNAL OF BIOCHEMISTRY

The initiation region of the SV40 VP1 gene

André Van de VoordeRoland ContrerasRaphaël RogiersWalther Fiers

A1 Journal Article in CELL

1975

3'-Terminal nucleotide-sequence (n = 361) of bacteriophage MS2 RNA

Antoon VandenbergheWilly Min JouWalther Fiers

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A method for the isolation of cytidylate series from ribonuclease T1-oligonucleotides

Roland ContrerasWalther Fiers

A1 Journal Article in ANALYTICAL BIOCHEMISTRY

A-Protein gene of bacteriophage MS2

Walther FiersRoland ContrerasFred DuerinckGuy HaegemanJozef MerregaertWilly Min JouAlex RaeymakersGuido VolckaertMarc YsebaertJoël Vandekerckhove et al.

A1 Journal Article in NATURE

Location of the small restriction fragments, Hind-L, Hind-M and Hpa-E, on the simian virus 40 genome

R YangK DannaAndré Van de VoordeWalther Fiers

A1 Journal Article in VIROLOGY

Rapid detection method for mycoplasma contamination of plants

J. Van EmmeloE. GillisWalther Fiers

A2 Journal Article in MEDEDELINGEN VAN DE FACULTEIT LANDBOUWWETENSCHAPPEN - RIJKSUNIVERSITEIT GENT

1974

A simple and highly sensitive method for sequence determination of 32P-labeled oligonucleotides

Guido VolckaertWalther Fiers

A1 Journal Article in ANALYTICAL BIOCHEMISTRY

Deoxynucleotide substitution : new technique for sequence analysis of RNA

André Van de VoordeRaphaël RogiersJacqueline Van HerrewegheHugo Van HeuverswynGuido VolckaertWalther Fiers

A1 Journal Article in NUCLEIC ACIDS RESEARCH

1973

Bacteriophage MS2 RNA: nucleotide sequence of the end of the A protein gene and the intercistronic region

Roland ContrerasMarc YsebaertWilly Min JouWalther Fiers

A1 Journal Article in NATURE-NEW BIOLOGY

Studies on the bacteriophage MS2, XXII : conformation of MS2 RNA in acid medium

H SlegersWalther Fiers

A1 Journal Article in BIOPOLYMERS

Studies on the bacteriophage MS2, XXIII : fixation of the MS2 RNA acid structure by formaldehyde

H SlegersWalther Fiers

A1 Journal Article in BIOPOLYMERS

Studies on the bacteriophage MS2, XXIV : hydrodynamic properties of the native and acid MS2 RNA structures

H SlegersJulien ClauwaertWalther Fiers

A1 Journal Article in BIOPOLYMERS

Studies on the bacteriophage MS2: G-U-G as the initiation codon of the A-protein cistron

Guido VolckaertWalther Fiers

A1 Journal Article in FEBS LETTERS

Studies on the bacteriophage MS2: an internal nucleotide fragment resembling some ribosomal binding sites

Guy HaegemanWalther Fiers

A1 Journal Article in EUROPEAN JOURNAL OF BIOCHEMISTRY

The choice of code words in phage MS2 RNA

A1 Journal Article in NATURE-NEW BIOLOGY

1972

Bacteriophage MS2 RNA and Escherichia coli 23 S ribosomal RNA have a similar conformation after reaction with formaldehyde at low pH

H SlegersWalther Fiers

A1 Journal Article in FEBS LETTERS

Further evidence on the role of the A protein in bacteriophage MS2 particles

E VerbraekenWalther Fiers

A1 Journal Article in FEBS LETTERS

Nucleotide sequence of the gene coding for the bacteriophage MS2 coat protein

Willy Min JouMarc YsebaertWalther FiersGuy Haegeman

A1 Journal Article in NATURE

Possible role of the Qβ-RNA-dependent RNA-polymerase-stimulating component in the host cell (E. coli)

J. van EmmeloJ. De BoeverE. GillisWalther Fiers

A2 Journal Article in MEDEDELINGEN VAN DE FACULTEIT LANDBOUWWETENSCHAPPEN - RIJKSUNIVERSITEIT GENT

Preparative two-dimensional polyacrylamide gel electrophoresis of 32P-labeled RNA

Rupert De WachterWalther Fiers

A1 Journal Article in ANALYTICAL BIOCHEMISTRY

Studies on the bacteriophage MS2, XVI: the termination signal of the A protein cistron

Erik RemautWalther Fiers

A1 Journal Article in JOURNAL OF MOLECULAR BIOLOGY

Studies on the bacteriophage MS2, XVII: suppressor-sensitive mutants of the A protein cistron

E VandammeErik RemautMarc Van MontaguWalther Fiers

A1 Journal Article in MOLECULAR AND GENERAL GENETICS

Studies on the bacteriophage MS2, XX: expansion of the virion in low salt

E VerbraekenWalther Fiers

A1 Journal Article in VIROLOGY

Studies on the bacteriophage MS2: some nucleotide sequences from the RNA-polymerase gene

Roland ContrerasGuido VolckaertAntoon VandenbergheWalther FiersWilly Min Jou

A1 Journal Article in FEBS LETTERS

1971

A new method for partial digestion useful for sequence analysis of polynucleotides

Roland ContrerasWalther Fiers

A1 Journal Article in FEBS LETTERS

Cellular components involved in the RNA replication system of bacteriophage Qβ

J. De BoeverE. GillisWalther Fiers

A2 Journal Article in MEDEDELINGEN VAN DE FACULTEIT LANDBOUWWETENSCHAPPEN - RIJKSUNIVERSITEIT GENT

Host factor dependent and factor-free polyribonucleic acid synthesizing activities of the bacteriophage Qβ RNA replication enzyme

E. GillisJ. G. De BoeverJ. Van EmmeloWalther Fiers

Position of the first initiation codon in the RNA of bacteriophages MS2 and R17

R. De WachterA. VandenbergheJ. MerregaertRoland ContrerasWalther Fiers

Qβ viral RNA-dependent RNA polymerase

J. De BoeverE. GillisWalther Fiers

A2 Journal Article in MEDEDELINGEN VAN DE FACULTEIT LANDBOUWWETENSCHAPPEN - RIJKSUNIVERSITEIT GENT

Recent progress in the sequence determination of bacteriophage MS2 RNA

Walther FiersRoland ContrerasRupert De WachterGuy HaegemanJozef MerregaertWilly Min JouAntoon Vandenberghe

A1 Journal Article in BIOCHIMIE

Studies on the bacteriophage MS2 nucleotide sequence of a 3′-terminal fragment (n = 104)

Roland ContrerasAntoon VandenbergheWilly Min JouRupert De WachterWalther Fiers

A1 Journal Article in FEBS LETTERS

Studies on the bacteriophage MS2, IX: the heptanucleotide sequences present in the pancreatic ribonuclease digest of the viral RNA

Guy HaegemanWilly Min JouWalther Fiers

A1 Journal Article in JOURNAL OF MOLECULAR BIOLOGY

Studies on the bacteriophage MS2: nucleotide fragments from the coat protein cistron

Willy Min JouGuy HaegemanWalther Fiers

A1 Journal Article in FEBS LETTERS

Studies on the bacteriophage MS2: the untranslated 5'-terminal nucleotide sequence preceding the first cistron

Rupert De WachterJozef MerregaertAntoon VandenbergheRoland ContrerasWalther Fiers

A1 Journal Article in EUROPEAN JOURNAL OF BIOCHEMISTRY

The leader sequence from the 5'-terminus to the A-protein initiation codon in MS2-virus RNA

Rupert De WachterAntoon VandenbergheJozef MerregaertRoland ContrerasWalther Fiers

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

1970

Reaction of formaldehyde with viral MS2-RNA at low pH

H. SlegersWalther Fiers

Specific dimer formation of ribosomal RNA and of viral RNA in the presence of formaldehyde

H SlegersWalther Fiers

A1 Journal Article in FEBS LETTERS

Studies on bacteriophage MS2, VIII : evidence for dimer formation of MS2 RNA by reaction with formaldehyde at acidic pH

H. SleghersWalther Fiers

A1 Journal Article in BIOPOLYMERS

The 3′-terminal nucleotide sequence (n = 16) of bacteriophage MS2 RNA

Willy Min JouRoland ContrerasWalther Fiers

A1 Journal Article in FEBS LETTERS

The effect of salt concentration on the polyribonucleotide synthesizing activities in extracts of uninfected and RNA-bacteriophage infected 'Escherichia coli'

E. GillisJ. G. De BoeverWalther Fiers

A1 Journal Article in ARCHIVES INTERNATIONALES DE PHYSIOLOGIE ET DE BIOCHIMIE

The heptanucleotide sequences present in the pancreatic ribonuclease digest of bacteriophage MS2 RNA

Guy HaegemanWilly Min JouWalther Fiers

The tRNA pyrophosphorylase activity of Escherichia coli: a study on substrate specificity

Hans J GrossFred R DuerinckWalther Fiers

A1 Journal Article in EUROPEAN JOURNAL OF BIOCHEMISTRY

1969

Allocation of polypurine tracts to two fragments of bacteriophage MS2 RNA

Willy Min JouWalther FiersH GoodmanP Spahr

A1 Journal Article in JOURNAL OF MOLECULAR BIOLOGY

Qβ-virus RNA-afhankelijke RNA-polymerase

J. De BoeverE. GillisWalther Fiers

A2 Journal Article in MEDEDELINGEN VAN DE RIJKSFACULTEIT LANDBOUWWETENSCHAPPEN TE GENT

Sequences at the 5′-terminus of bacteriophage Qβ RNA

Rupert De WachterWalther Fiers

A1 Journal Article in NATURE

Studies on the bacteriophage MS2, 6: the nucleoside 5'-triphosphate end groups of the replicative intermediate and the replicative form

Antoon VandenbergheBenoni Van StyvendaeleWalther Fiers

A1 Journal Article in EUROPEAN JOURNAL OF BIOCHEMISTRY

Studies on the bacteriophage MS2, VII: structure determination of the longer polypurine sequences present in the pancreatic ribonuclease digest of the viral RNA

Willy Min JouWalther Fiers

A1 Journal Article in JOURNAL OF MOLECULAR BIOLOGY

Studies on the primary structure and the replication mechanism of bacteriophage RNA

Walther FiersMarc Van MontaguRupert De WachterGuy HaegemanWilly Min JouEric MessensErik RemautAntoon VandenbergheBenoni Van Styvendaele

A1 Journal Article in COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY

The base sequence at the 5'-terminus of bacteriophage Qβ RNA

R. De WachterJ. P. VerhasselWalther Fiers

The factor-dependence of bacteriophage Qβ RNA-polymerase

E. GillisJ. G. De BoeverWalther Fiers

1968

Bacteriophage MS2 induced proteins

E. RemautE. VerbraekenWalther Fiers

Model substrates for the rapid assay of specific ribonuclease activity

Francis MolemansMarc Van MontaguWalther Fiers

A1 Journal Article in EUROPEAN JOURNAL OF BIOCHEMISTRY

The 5'-terminal end group of the ribonucleic acid of the bacteriophage MS2

R. De WachterJ. P. VerhasselWalther Fiers

The 5'-terminal tetranucleotide sequence of bacteriophage MS2 ribonucleic acid

R. De WachterJ. P. VerhasselWalther Fiers

The 5′-terminal end group of the RNA of the bacteriophage MS2

Rupert De WachterJ-P VerhasselWalther Fiers

A1 Journal Article in BIOCHIMICA ET BIOPHYSICA ACTA

1967

Double-stranded RNA from 'Escherichia coli' infected with the bacterophage MS2 : the parental RNA-labelled replicative forms and properties of an infectious RNA-containing structure

B. Van StyvendaeleWalther Fiers

External standardization in liquid scintillation counting of homogeneous samples labeled with one, two, or three isotopes

Rupert De WachterWalther Fiers

A1 Journal Article in ANALYTICAL BIOCHEMISTRY

Studies on the bacteriophage MS2, III: sedimentation heterogeneity of viral RNA preparations

A1 Journal Article in VIROLOGY

Studies on the bacteriophage MS2, IV: the 3'-OH terminal undecanucleotide sequence of the viral RNA chain

Rupert De WachterWalther Fiers

A1 Journal Article in JOURNAL OF MOLECULAR BIOLOGY

Viral RNA polymerase levels induced in non-permissive 'Escherichia coli' cells by suppressor-sensitive mutants of bacteriophage MS2

E. GillisE. VandammeWalther Fiers

1966

Rhythmic genetic code of ribonucleic acid bacteriophages

A1 Journal Article in NATURE

The distribution of tetranucleotides present in the pancreatic ribonuclease digests of bacteriophage MS2 RNA and yeast RNA

P VandenbusscheWalther Fiers

A1 Journal Article in BIOCHIMICA ET BIOPHYSICA ACTA

1963

Studies on polynucleotides, XXII: enzymic degradation: an exonuclease from Lactobacillus acidophilus R26, A: purification, properties, and substrate specificity

Walther FiersH Gobind Khorana

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Studies on polynucleotides, XXIII: enzymic degradation: an exonuclease from Lactobacillus acidophilus R26, B: stepwise degradation of oligonucleotides

Walther FiersH Gobind Khorana

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

1962

The chromatography of barley ribonuclease

A1 Journal Article in JOURNAL OF CHROMATOGRAPHY

The reaction mechanism of a nucleoside phosphorylase

Walther FiersJean de Bersaques

A1 Journal Article in ENZYMOLOGIA

The structure of the DNA of bacteriophage φX174, I: the action of exopolynucleotidases

Walther FiersRobert L Sinsheimer

A1 Journal Article in JOURNAL OF MOLECULAR BIOLOGY

The structure of the DNA of bacteriophage φX174, II: thermal inactivation

Walther FiersRobert L Sinsheimer

A1 Journal Article in JOURNAL OF MOLECULAR BIOLOGY

The structure of the DNA of bacteriophage φX174, III: ultracentrifugal evidence for a ring structure

Walther FiersRobert L Sinsheimer

A1 Journal Article in JOURNAL OF MOLECULAR BIOLOGY

1961

The determination of ribonuclease activity

A1 Journal Article in ANALYTICAL BIOCHEMISTRY

1960

Nature of the acid phosphatase present in scales of human skin

Walther FiersJean de Bersaques

A1 Journal Article in JOURNAL OF INVESTIGATIVE DERMATOLOGY

1958

A micro method for the determination of ribonuclease activity

Walther FiersKM Moller

A1 Journal Article in COMPTES RENDUS DES TRAVAUX DU LABORATOIRE CARLSBERG

1957

Ein neues Fällungsmittel für Ribonucleinsäure und seine Anwendung bei der Bestimmung von Ribonuclease

Walther FiersJan Stockx

A1 Journal Article in NATURWISSENSCHAFTEN