Research Explorer

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Researcher

Vesna Melkebeek

Publications & Research Data

Awards & Distinctions

56 Results

2017

High susceptibility prevalence for F4⁺ and F18⁺ Escherichia coli in Flemish pigs

Ut Nguyen VanAnnelies CoddensVesna MelkebeekBert DevriendtTiphanie GoetstouwersMario Van PouckeLuc PeelmanEric Cox

A1 Journal Article in VETERINARY MICROBIOLOGY

2015

High susceptibility rate for F4+ and F18+ enterotoxigenic Escherichia coli in Belgian pigs

Ut Nguyen VanAnnelies CoddensVesna MelkebeekTiphanie GoetstouwersMario Van PouckeLuc PeelmanEric Cox

Maternal immunity enhances systemic recall immune responses upon oral immunization of piglets with F4 fimbriae

Ut Nguyen VanVesna MelkebeekBert DevriendtTiphanie GoetstouwersMario Van PouckeLuc PeelmanBruno GoddeerisEric Cox

A1 Journal Article in VETERINARY RESEARCH

Targeting the small intestinal F4-receptor in piglets with maternal antibodies results in enhanced recall responses

Ut Nguyen VanVesna MelkebeekBert DevriendtTiphanie GoetstouwersMario Van PouckeLuc PeelmanBruno GoddeerisEric Cox

Targeting yeast ghosts to epithelial CD13 promotes mucosal immunity

Bert DevriendtKim BaertVesna MelkebeekMartine De VosEric Cox

2014

Effect of fatty acid composition of the sow diet on the innate and adaptive immunity of the piglets after weaning

Sofie TangheEric CoxVesna MelkebeekStefaan De SmetSam Millet

A1 Journal Article in VETERINARY JOURNAL

F4-related mutation and expression analysis of the aminopeptidase N gene in pigs

Tiphanie GoetstouwersMario Van PouckeUt Nguyen VanVesna MelkebeekAnnelies CoddensDieter DeforceEric CoxLuc Peelman

A1 Journal Article in JOURNAL OF ANIMAL SCIENCE

Refined candidate region for F4ab/ac enterotoxigenic Escherichia coli susceptibility situated proximal to MUC13 in pigs

Tiphanie GoetstouwersMario Van PouckeWouter CoppietersUt Nguyen VanVesna MelkebeekAnnelies CoddensKatleen Van SteendamDieter DeforceEric CoxLuc Peelman

A1 Journal Article in PLOS ONE

Vaccines against enteric E.coli infections in animals

Eric CoxVesna MelkebeekBert DevriendtBruno GoddeerisDaisy Vanrompay

Bookchapter in Pathogenic Escherichia coli : molecular and cellular microbiology

Variation in 12 porcine genes involved in the carbohydrate moiety assembly of glycosphingolipids does not account for differential binding of F4 Escherichia coli and their fimbriae

Tiphanie GoetstouwersMario Van PouckeAnnelies CoddensUt Nguyen VanVesna MelkebeekDieter DeforceEric CoxLuc Peelman

A1 Journal Article in BMC GENETICS

2013

Crossing the barrier: targeting epithelial receptors for antigen delivery to the mucosal immune system

Bert DevriendtVesna MelkebeekBruno GoddeerisEric Cox

Differentiation of F4 receptor profiles in pigs based on their mucin 4 polymorphism, responsiveness to oral F4 immunization and in vitro binding of F4 to villi

Ut Nguyen VanTiphanie GoetstouwersAnnelies CoddensMario Van PouckeLuc PeelmanDieter DeforceVesna MelkebeekEric Cox

A1 Journal Article in VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY

Effect of fatty acid composition of the sows' diet on selected immune parameters of the piglets after weaning

Sam MilletSofie TangheVesna MelkebeekStefaan De SmetEric Cox

Elispot on enriched IgA+ B-lymphocytes can be used to detect the IgA response following oral immunization with F4 fimbriae of pigs with colostral F4-specific serum antibodies

Ut Nguyen VanVesna MelkebeekTiphanie GoetstouwersMario Van PouckeLuc PeelmanBruno GoddeerisEric Cox

ETEC vaccination in pigs

Vesna MelkebeekBruno GoddeerisEric Cox

A1 Journal Article in VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY

Interaction of E. coli with the intestinal immune system of the pig in the post-weaning period

Eric CoxBert DevriendtVesna MelkebeekDaisy VanrompayBruno Goddeeris

Local and systemic immune responses in pigs intramuscularly injected with an inactivated Mycoplasma hyopneumoniae vaccine

Silvana Beutinger MarchioroDominiek MaesBram FlahouFrank PasmansRubén Del Pozo SacristánKatleen VranckxVesna MelkebeekEric CoxNiels WuytsFreddy Haesebrouck

A1 Journal Article in VACCINE

Maltose-binding protein is a potential carrier for oral immunizations

Philippe BellotPetra TielsVesna MelkebeekBert DevriendtBruno GoddeerisEric Cox

A1 Journal Article in VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY

New strategies for oral immunization : targeting soluble antigens or delivery of particles to the intestinal mucosa

Philippe BellotEric CoxBruno GoddeerisVesna Melkebeek

2012

Post-weaning E. coli infections in pigs and importance of the immune system

Eric CoxMichaela LoosAnnelies CoddensBert DevriendtVesna MelkebeekDaisy VanrompayBruno Goddeeris

Targeting aminopeptidase N, a newly identified receptor for F4ac fimbriae, enhances the intestinal mucosal immune response

Vesna MelkebeekK RasschaertPhilippe BellotK TillemanHerman FavoreelDieter DeforceBruno De GeestBruno GoddeerisEric Cox

A1 Journal Article in MUCOSAL IMMUNOLOGY

The consecutive infection with Toxoplasma gondii strains affects the parasitic load in tissues of experimentally infected pigs

Malgorzata JennesStephane De CraeyeDelfien VerhelstPierre DornyKatelijne DierickVesna MelkebeekEric Cox

Towards identifying porcine F4 ETEC receptors by comparing F4-binding brush border membrane proteins between well characterized groups of pigs

Ut Nguyen VanVesna MelkebeekTiphanie GoetstouwersAnnelies CoddensMario Van PouckeLuc PeelmanEric Cox

2011

Adjuvant effect of Gantrez®AN nanoparticles during oral vaccination of piglets against F4+enterotoxigenic Escherichia coli

Katrien VandammeVesna MelkebeekEric CoxJean Paul RemonChris Vervaet

A1 Journal Article in VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY

Aminopeptidase N is a target for a very rapid IgA response upon a primary oral immunisation

Eric CoxPhilippe BellotVesna Melkebeek

IFN-γ expression and infectivity of Toxoplasma infected tissues are associated with an antibody response against GRA7 in experimentally infected pigs

Delfien VerhelstStéphane De CraeyePierre DornyVesna MelkebeekBruno GoddeerisEric CoxE Jongert

A1 Journal Article in VETERINARY PARASITOLOGY

Influence of polymer hydrolysis on adjuvant effect of Gantrez®AN nanoparticles: implications for oral vaccination

Katrien VandammeVesna MelkebeekEric CoxPeter AdriaensensSandra Van VlierberghePeter DubruelChris VervaetJean Paul Remon

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Maltose-binding protein (MBP) is a potential carrier for oral immunizations

Philippe BellotVesna MelkebeekEric Cox

Maltose-binding protein is a potential carrier for oral immunizations

Philippe BellotPetra TielsVesna MelkebeekEric Cox

Mucin 4 polymorphism, F4 binding to villi and brush border membrane proteins and F4 immunisation can differentiate pigs as tools towards identifying F4R

Ut Nguyen VanTiphanie GoetstouwersMario Van PouckeAnnelies CoddensVesna MelkebeekLuc PeelmanEric Cox

T. gondii strains and their dosage influence the parasitic load in tissues of experimentally infected pigs

Stéphane De CraeyeMalgorzata JennesDelfien VerhelstPierre DornyKatelijne DierickVesna MelkebeekEric Cox

The adjuvant effect of Gantrez®AN nanoparticles on oral vaccination of pigs and mice with F4 fimbriae is strongly influenced by polymer degradation

Katrien VandammeVesna MelkebeekChris VervaetJean Paul RemonEric Cox

The adjuvant effect of Gantrez®AN nanoparticles on oral vaccination of pigs and mice with F4 fimbriae is strongly influenced by polymer degradation

Vesna MelkebeekKatrien VandammeChris VervaetEric Cox

Vaccination against ETEC in pigs

Vesna MelkebeekBruno GoddeerisEric Cox

2010

Adjuvant effect of Gantrez AN nanoparticles during oral vaccination with F4 fimbriae

Katrien VandammeVesna MelkebeekEric CoxP AdriaensensChris VervaetJean Paul Remon

Aminopeptidase N as a target for oral vaccine delivery

Vesna MelkebeekKatrien VandammeChris VervaetJean Paul RemonEric Cox

Cytokine responses and parasitic clearance in pigs infected with different dosages of Toxoplasma gondii

Malgorzata JennesStéphane De CraeyeDelfien VerhelstPierre DornyKathelijne DierickVesna MelkebeekEric Cox

Evaluation of parasite antigens in Elisa for the detection of toxoplasma infection in pigs

Delfien VerhelstS De CraeyeVesna MelkebeekEric Cox

Influence of reaction medium during synthesis of Gantrez® AN 119 nanoparticles for oral vaccination

Katrien VandammeVesna MelkebeekEric CoxDieter DeforceJoke LenoirEls AdriaensChris VervaetJean Paul Remon

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Maltose-binding protein (MBP) is a potential carrier for oral immunizations

Philippe BellotPetra TielsFrank VerdonckVesna MelkebeekBruno GoddeerisEric Cox

Polymer degradation influences the adjuvant effect of Gantrez nanoparticles on oral vaccinati of pigs and mice with F4

Vesna Melkebeek

2009

Molecular cloning and characterization of the porcine prostaglandin transporter (SLCO2A1): evaluation of its role in F4 mediated neonatal diarrhoea

Mario Van PouckeVesna MelkebeekTim ErkensAlex Van ZeverenEric CoxLuc Peelman

A1 Journal Article in BMC GENETICS

2008

An enhanced GRA1-GRA7 cocktail DNA vaccine primes anti-Toxoplasma immune responses in pigs

E JONGERTVesna MelkebeekS DE CRAEYEJ DEWITDelfien VerhelstEric Cox

A1 Journal Article in VACCINE

Effect of plasmid DNA encoding the porcine granulocyte-macrophage colony-stimulating factor on antigen-presenting cells in pigs

Vesna MelkebeekWim Van Den BroeckFrank VerdonckBruno GoddeerisEric Cox

A1 Journal Article in VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY

2007

A GRA1-GRA7 cocktail DNA vaccine primes anti-Toxoplasma immune responses in mice and pigs

Vesna MelkebeekEric Cox

Comparison of immune responses in parenteral FaeG DNA primed pigs boosted orally with F4 protein or reimmunized with the DNA vaccine

Vesna MelkebeekF VERDONCKBruno GoddeerisEric Cox

A1 Journal Article in VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY

Optimization of an FaeG DNA vaccine in pigs

Vesna MelkebeekEric CoxBruno Goddeeris

Optimized FaeG expression and a thermolabile enterotoxin DNA adjuvant enhance priming of an intestinal immune response by an FaeG DNA vaccine in pigs

Vesna MelkebeekEva SonckFrank VerdonckBruno GoddeerisEric Cox

A1 Journal Article in CLINICAL AND VACCINE IMMUNOLOGY

2006

Optimization of the FaeG expressoin and the use of adjuvantia enhance priming by an FaeG DNA vaccine in pigs

Vesna Melkebeek

Plasmid-encoded GM-CSF induces priming of the F4(K88)-specific serum IgA response by FaeG DNA vaccination in pigs

Vesna MelkebeekFrank VerdonckEdith StuyvenBruno GoddeerisEric Cox

A1 Journal Article in VACCINE

2005

Intradermal delivery of plasmid DNA encoding the porcine GM-CSF recruits antigen-presenting cells to the injection site and enhances the immune response to an FaeG DNA vaccine

Vesna MelkebeekEdith StuyvenBruno GoddeerisEric Cox

Priming of the intestinal mucosal immune system by an intradermal DNA vaccination strategy

Eric CoxVesna MelkebeekEva SonckBruno Goddeeris

2004

Influence of delivery route and administration of plasmid DNA encoding the porcine GM-CSF on priming of piglets against F4+ enterotoxigenic E. coli following immunisation with FaeG DNA

Vesna MelkebeekEric CoxEdith StuyvenBruno Goddeeris

Intradermal injection of pigs with plasmid DNA encoding GM-CSF attracts antigen-presentig cells to porcine epidermis and improves the FaeG-specific lymphocyte proliferation to an FaeG DNA vaccine

Vesna MelkebeekEdith StuyvenEric CoxBruno Goddeeris

Optimalisation of an FAEG DNA vaccine to prime an F4-specific immune response in piglets

Vesna MelkebeekEva SonckBruno GoddeerisEric Cox

Priming of piglets against enterotoxigenic E-coli F4 fimbriae by immunisation with FAEG DNA

Tine VerfaillieVesna MelkebeekVeerle SnoeckS DOUTERLUNGNEEric CoxFrank VerdonckDaisy VanrompayBruno Goddeeris

A1 Journal Article in VACCINE