Research Explorer

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Researcher

Vera Goossens

Awards & Distinctions

43 Results

2025

Development and validation of a high-throughput screening pipeline of compound libraries to target EMT

Sven JonckheereJoachim TaminauJamie AdamsJef HaerinckJordy De ConinckJeroen VerstappeKato De ClercqEvelien PeetersAlexander GheldofEva De Smedt et al.

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Sequential orthogonal assays for longitudinal and endpoint characterization of three-dimensional spheroids

Eva BlondeelSam ErnstFelix De VuystÁkos DiósdiCláudio PinheiroDiogo EstêvãoPekka RappuRobin BoiySandor DedeyneLigia Craciun et al.

A1 Journal Article in NATURE PROTOCOLS

Sequential orthogonal assays for longitudinal and endpoint characterization of three-dimensional spheroids (Apr, 10.1038/s41596-025-01150-y, 2025)

Eva BlondeelSam ErnstFelix De VuystÁkos DiósdiCláudio PinheiroDiogo Miguel Monteiro EstêvãoPekka RappuRobin BoiySandor DedeyneLigia Craciun et al.

2024

Improving cardiac differentiation of human pluripotent stem cells by targeting ferroptosis

Jeffrey AaldersLaurens LégerBehrouz HassanniaVera GoossensTom Vanden BergheJolanda van Hengel

A1 Journal Article in REGENERATIVE THERAPY

Local structural preferences in shaping tau amyloid polymorphism

Nikolaos LourosMartin WilkinsonGrigoria TsakaMeine RamakersChiara MorelliTeresa GarciaRodrigo GallardoSam D'HaeyerVera GoossensDominique Audenaert et al.

A1 Journal Article in NATURE COMMUNICATIONS

Nitrate and ammonium, the yin and yang of nitrogen uptake : a time-course transcriptomic study in rice

Pierre-Mathieu PélissierBoris ParizotLetian JiaAlexa De KnijfVera GoossensPascal GantetAntony ChampionDominique AudenaertWei XuanTom Beeckman et al.

A1 Journal Article in FRONTIERS IN PLANT SCIENCE

SPL13 controls a root apical meristem phase change by triggering oriented cell divisions

Baojun YangYanbiao SunMax MinneYanhua GeQianru YueVera GoossensEliana MorBrenda CallebautKevin BevernaegeJohan Winne et al.

A1 Journal Article in SCIENCE

2023

Systematic optimization of Cas12a base editors in wheat and maize using the ITER platform

Christophe GaillochetAlexandra Pena FernandezVera GoossensKatelijn D’HalluinAndrzej DrozdzeckiMyriam ShafieJulie Van DuyseGert Van IsterdaelCamila GonzalezMattias Vermeersch et al.

A1 Journal Article in GENOME BIOLOGY

2022

Mapping the sequence specificity of heterotypic amyloid interactions enables the identification of aggregation modifiers

Nikolaos LourosMeine RamakersEmiel MichielsKaterina KonstantouleaChiara MorelliTeresa GarciaNele MoonenSam D'HaeyerVera GoossensDietmar Rudolf Thal et al.

A1 Journal Article in NATURE COMMUNICATIONS

Reduced protection of RIPK3-deficient mice against influenza by matrix protein 2 ectodomain targeted active and passive vaccination strategies

Teodora-Eugenia OlteanLorena IbanezTatyana DivertTine YsenbaertHannelore Van EeckhoutteVera GoossensMichael SchotsaertKen BrackeBert SchepensJonathan Maelfait et al.

A1 Journal Article in CELL DEATH & DISEASE

2021

MISpheroID : a knowledgebase and transparency tool for minimum information in spheroid identity

Arne PeirsmanEva BlondeelTasdiq AhmedJasper AnckaertDominique AudenaertTom BoterbergKrisztina BuzasNeil CarragherGastone CastellaniFlávia Castro et al.

A1 Journal Article in NATURE METHODS

2020

Ionizing radiation results in a mixture of cellular outcomes including mitotic catastrophe, senescence, methuosis, and iron-dependent cell death

Sandy Adjemian CataniTeodora-Eugenia OlteanSofie MartensBartosz WiernickiVera GoossensTom Vanden BergheBenjamin CappeMaria LadikFranck RiquetLiesbeth Heyndrickx et al.

A1 Journal Article in CELL DEATH & DISEASE

2019

Necroptotic proteins in diseases : targeting RIP kinases in inflammatory disorders and exploring the role of MLKL in melanoma development

Sofie MartensPeter VandenabeeleNozomi TakahashiVera Goossens

2018

Multi-parametric screening in Arabidopsis thaliana seedlings

Long NguyenAndrzej DrozdzeckiVera GoossensBert De RybelTom BeeckmanDominique Audenaert

Bookchapter in Plant chemical genomics : methods and protocols

RIPK1-dependent cell death : a novel target of the Aurora kinase inhibitor Tozasertib (VX-680)

Sofie MartensVera GoossensLars DevisscherSam HofmansPolien ClaeysMarnik VuylstekeNozomi TakahashiKoen AugustynsPeter Vandenabeele

A1 Journal Article in CELL DEATH & DISEASE

Tozasertib analogues as inhibitors of necroptotic cell death

Sam HofmansLars DevisscherSofie MartensDries Van RompaeyKenneth GoossensTatyana DivertWim NerinckxNozomi TakahashiHans De WinterPieter Van der Veken et al.

A1 Journal Article in JOURNAL OF MEDICINAL CHEMISTRY

2017

Sorafenib tosylate inhibits directly necrosome complex formation and protects in mouse models of inflammation and tissue injury

Sofie MartensManhyung JeongWulf TonnusFriederike FeldmannSam HofmansVera GoossensNozomi TakahashiJan Hinrich BraesenEun-Woo LeePieter Van der Veken et al.

A1 Journal Article in CELL DEATH & DISEASE

2016

A real-time fluorometric method for the simultaneous detection of cell death type and rate

Sasker GrootjansBehrouz HassanniaIris DelrueVera GoossensBartosz WiernickiYves DondelingerMathieu BertrandDmitri KryskoMarnik VuylstekePeter Vandenabeele et al.

A1 Journal Article in NATURE PROTOCOLS

A siRNA screen reveals the prosurvival effect of protein kinase A activation in conditions of unresolved endoplasmic reticulum stress

Miguel AguiletaDiego Rojas RiveraVera GoossensYann EstornesGert Van IsterdaelPeter VandenabeeleMathieu Bertrand

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

2015

Antioxidant potential of CORM-A1 and resveratrol during TNF-α/cycloheximide-induced oxidative stress and apoptosis in murine intestinal epithelial MODE-K cells

Dinesh BabuGeorges LeclercqVera GoossensQuinten RemijsenPeter VandenabeeleRoberto MotterliniRomain Lefebvre

A1 Journal Article in TOXICOLOGY AND APPLIED PHARMACOLOGY

Mitochondria and NADPH oxidases are the major sources of TNF-α/cycloheximide-induced oxidative stress in murine intestinal epithelial MODE-K cells

Dinesh BabuGeorges LeclercqVera GoossensTom Vanden BergheEvelien Van HammePeter VandenabeeleRomain Lefebvre

A1 Journal Article in CELLULAR SIGNALLING

2014

Depletion of RIPK3 or MLKL blocks TNF-driven necroptosis and switches towards a delayed RIPK1 kinase-dependent apoptosis

Quinten RemijsenVera GoossensSasker GrootjansC Van den HauteNele VanlangenakkerYves DondelingerRia RoelandtInge BruggemanAmanda GonçalvesMathieu Bertrand et al.

A1 Journal Article in CELL DEATH & DISEASE

Methods to study and distinguish necroptosis

Sasker GrootjansVera GoossensPeter VandenabeeleTom Vanden Berghe

Bookchapter in Necrotic cell death

RIPK1 ensures intestinal homeostasis by protecting the epithelium against apoptosis

Nozomi TakahashiLars VereeckeMathieu BertrandLinde DuprezScott B BergerTatyana DivertAmanda GonçalvesMozes SzeBarbara GilbertStephanie Kourula et al.

A1 Journal Article in NATURE

RIPK1 promotes death receptor-independent caspase-8-mediated apoptosis under unresolved ER stress conditions

Yann EstornesMiguel AguiletaChristel DubuissonJulie De KeyserVera GoossensKristof KersseA SamaliPeter VandenabeeleMathieu Bertrand

A1 Journal Article in CELL DEATH & DISEASE

2013

Determination of apoptotic and necrotic cell death in vitro and in vivo

Tom Vanden BergheSasker GrootjansVera GoossensYves DondelingerDmitri KryskoNozomi TakahashiPeter Vandenabeele

A1 Journal Article in METHODS

RIPK3 contributes to TNFR1-mediated RIPK1 kinase-dependent apoptosis in conditions of cIAP1/2 depletion or TAK1 kinase inhibition

Yves DondelingerMiguel AguiletaVera GoossensChristel DubuissonSasker GrootjansE DejardinPeter VandenabeeleMathieu Bertrand

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

The soluble guanylate cyclase activator BAY 58-2667 protects against morbidity and mortality in endotoxic shock by recoupling organ systems

Benjamin VandendriesscheElke RoggeVera GoossensPeter VandenabeeleJohannes-Peter StaschPeter BrouckaertAnje Cauwels

A1 Journal Article in PLOS ONE

2012

Necrostatin-1 analogues: critical issues on the specificity, activity and in vivo use in experimental disease models

Nozomi TakahashiLinde DuprezSasker GrootjansAnje CauwelsWim NerinckxJB DuHadawayVera GoossensRia RoelandtFilip Van HauwermeirenClaude Libert et al.

A1 Journal Article in CELL DEATH & DISEASE

2011

RIP Kinase-dependent necrosis drives lethal systemic inflammatory response syndrome

Linde DuprezNozomi TakahashiFilip Van HauwermeirenBenjamin VandendriesscheVera GoossensTom Vanden BergheWim DeclercqClaude LibertAnje CauwelsPeter Vandenabeele

A1 Journal Article in IMMUNITY

2004

Buffering properties of cationic polymethacrylates are not the only key to successful gene delivery

Peter DubruelBart ChristiaensMaryvonne RosseneuJoël VandekerckhoveJohan GrootenVera GoossensEtienne Schacht

A1 Journal Article in BIOMACROMOLECULES

2000

Role of reactive oxygen species in tumor necrosis factor toxicity

Vera GoossensKurt De VosDominique VercammenMargino SteemansKatia VancompernolleWalter FiersPeter VandenabeeleJohan Grooten

Bookchapter in Antioxidant and redox regulation of genes

Tumor necrosis factor induces hyperphosphorylation of kinesin light chain and inhibits kinesin-mediated transport of mitochondria.

Kurt De VosF SEVERINF VAN HERREWEGHEK VANCOMPERNOLLEVera GoossensA HYMANJohan Grooten

A1 Journal Article in JOURNAL OF CELL BIOLOGY

1999

Redox regulation of TNF signaling.

Vera GoossensKurt De VosD VERCAMMENMargino SteemansK VANCOMPERNOLLEWalter FiersPeter VandenabeeleJohan Grooten

A1 Journal Article in BIOFACTORS

1998

A caspase-activated factor (CAF) induces mitochondrial membrane depolarization and cytochrome c release by a nonproteolytic mechanism.

Margino SteemansVera GoossensMarc Van De CraenF VAN HERREWEGHEKatia VancompernolleKurt De VosPeter VandenabeeleJohan Grooten

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

Inhibition of caspases increases the sensitivity of L929 cells to necrosis mediated by tumor necrosis factor.

Dominique VercammenRudi BeyaertGeertrui DeneckerVera GoossensGeert van LooWim DeclercqJohan GrootenWalter FiersPeter Vandenabeele

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

Quiescence-inducing and antiapoptotic activities of IL-15 enhance secondary CD4(+) T cell responsiveness to antigen.

B DOOMSMarjory DesmedtS VANCAENEGHEMPieter RottiersVera GoossensWalter FiersJohan Grooten

A1 Journal Article in JOURNAL OF IMMUNOLOGY

The 55-kDa tumor necrosis factor receptor induces clustering of mitochondria through its membrane-proximal region.

Kurt De VosVera GoossensElke BooneDominique VercammenK VANCOMPERNOLLEPeter VandenabeeleGuy HaegemanWalter FiersJohan Grooten

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

1997

Tumour necrosis factor: intracellular mechanism of action

Walter FiersRudi BeyaertElke BooneWim DeclercqEls DecosterDirk De ValckVera GoossensJohan GrootenGuy HaegemanKaren Heyninck et al.

Bookchapter in HIV and cytokines

1996

Rol van mitochondriën in het cytotoxisch aktiemechanisme van tumor nekrosis faktor in tumorcellen

Vera GoossensWalter FiersJ. Grooten

TNF-induced intracellular signaling leading to gene induction or to cytotoxicity by necrosis or by apoptosis.

Walter FiersRudi BeyaertElke BooneSigrid CornelisWim DeclercqEls DecosterGeertrui DeneckerBart DepuydtDirk De ValckG DEWILDE et al.

A1 Journal Article in JOURNAL OF INFLAMMATION

The oxidative metabolism of glutamine - A modulator of reactive oxygen intermediate-mediated cytotoxicity of tumor necrosis factor in L929 fibrosarcoma cells.

Vera GoossensJohan GrootenWalter Fiers

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

1993

Two pathways of tumor necrosis factor signal transduction: in vitro and in vivo implications

Walter FiersRudi BeyaertPeter BrouckaertAnje CauwelsWim DeclercqDirk De ValckB EveraerdtVera GoossensJohan GrootenGuy Haegeman et al.