Research Explorer

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Researcher

Valérie Vanhoorne

Publications & Research Data

Awards & Distinctions

129 Results

2026

Continuous twin screw wet granulation of low-dose formulations : impact of process variables and API/binder addition methods on granule quality attributes

Louis BouckaertMathieu OmbecqGiorgia AdamoChristoph PortierValérie VanhoorneChris Vervaet

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Critical material attributes during continuous twin-screw wet granulation

Valérie VanhoornePhaedra DenduyverChris Vervaet

Bookchapter in Handbook of pharmaceutical wet granulation : theory and practice in a quality by design paradigm

Exploring twin-screw feeding behaviour across different loss-in-weight feeders

A. De ManB. Van SnickT. VerbeekM. OtavaAshish KumarChris VervaetValérie VanhoorneThomas De Beer

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

In-line blend potency measurements of low-dose formulations using a novel deep-UV LIF probe in the feed frame of a rotary tablet press

Louis BouckaertRohit BhartiaZhenqi ShiRay ReidKen NguyenJason MicklewrightWilliam HugAndrew AndersonTom Van Den KerkhofMario Hellings et al.

A1 Journal Article in ANALYTICAL CHEMISTRY

2025

Anti-regurgitation infant formulas and antacid medication : match or mismatch?

Eline TommeleinKyara BaertMathieu OmbecqSilke HenryValérie Vanhoorne

A1 Journal Article in EUROPEAN JOURNAL OF PEDIATRICS

Comparative analysis of tablet dissolution behavior : batch vs. continuous direct compression

Kensaku MatsunamiAlexander RyckaertHanne VerrecasAna Filipa Tavares da SilvaAndrew AndersonHåkan WikströmMelanie DumareyJames MannThomas De BeerValérie Vanhoorne et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Detection and management of pill swallowing difficulties : a community pharmacy‑based observational study

Goedele CrayeEls MehuysSien SchelfhoutJolien VandermoereJara RousseauMirko PetrovicKoen BousseryValérie Vanhoorne

A1 Journal Article in INTERNATIONAL JOURNAL OF CLINICAL PHARMACY

From print settings to printlet performance : a study on critical quality attributes in pellet-based direct extrusion additive manufacturing

Lotte De WeverCaitlin GoemaereGiorgio PeroniChandra WinardhiMatthieu BooneVeerle CnuddeLudwig CardonChris VervaetValérie Vanhoorne

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

In-line NIR spectroscopy for comprehensive process understanding of semi-continuous blending in continuous production of low-dose formulations

Louis BouckaertAlexander De ManLisa De SouterFabian StarsichBernhard MeirSebastian SowinskiChris VervaetThomas De BeerValérie Vanhoorne

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Investigating the effects of formulation and manufacturing routes on the tensile strength and disintegration time of tablets containing an HPMC AS-based spray dried powder

Tatiana MarcozziMartin OtavaSune Klint AndersenChris VervaetValérie Vanhoorne

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Mathematical models of dissolution testing : challenges and opportunities toward real-time release testing

Kensaku MatsunamiAlexander RyckaertValérie VanhoorneAshish Kumar

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Revolutionizing controlled release formulations : unlocking the potential of twin-screw wet granulation and semi-continuous pan coating

Phaedra DenduyverValérie VanhoorneChris Vervaet

Synchrotron computed tomography combined with AI-based image analysis for the advanced characterization of spray dried amorphous solid dispersion particles

Tatiana MarcozziSruthika BaviriseatyPhillip YawmanShawn ZhangChris VervaetValérie VanhoorneSune Klint Andersen

A1 Journal Article in JOURNAL OF PHARMACEUTICAL SCIENCES

The effect of filler particle size on API homogeneity of controlled release formulations via continuous twin-screw wet granulation

Phaedra DenduyverChris VervaetValérie Vanhoorne

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

The impact of glidant addition on continuous blending of active pharmaceutical ingredients

Tom VerbeekAlexander De ManBernd Van SnickMartin OtavaThomas De BeerAshish KumarChris VervaetValérie Vanhoorne

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

The impact of glidant addition on the loss-in-weight feeding of active pharmaceutical ingredients

Tom VerbeekAlexander De ManMelissa DebackerBram BekaertBernd Van SnickMartin OtavaChris VervaetValérie Vanhoorne

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

The impact of glidants on the rheological properties of active pharmaceutical ingredients : a study of conventional and alternative flow enhancers

Tom VerbeekAlexander De ManBernd Van SnickMartin OtavaChris VervaetValérie Vanhoorne

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

2024

Batch vs. continuous direct compression : a comparison of material processability and final tablet quality

Bram BekaertPauline H. M. JanssenSara FathollahiDirk VanderroostTimo RoelofsBastiaan H. J. DickhoffChris VervaetValérie Vanhoorne

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS-X

Boosting powder flow : how flow enhancers revolutionize continuous direct compression

Tom VerbeekValérie VanhoorneChris Vervaet

Evaluation of polyvinyl alcohol as binder during continuous twin screw wet granulation

Phaedra DenduyverGudrun BirkAlessandra AmbruosiChris VervaetValérie Vanhoorne

A1 Journal Article in PHARMACEUTICS

Modified release 3D-printed capsules containing a ketoprofen self-nanoemulsifying system for personalized medical application

Bahaa ShaqourHiba NatshehNaim KittanaNidal JaradatMurad AbualhasanAhmad M. EidRuaa MoqadyAya AbuHijlehSaja Abu AlsaleemShahd Ratrout et al.

A1 Journal Article in ACS BIOMATERIALS SCIENCE & ENGINEERING

Radical improvements in the use of existing and novel antioxidants in pharmaceutical oral solid dosage forms

Milan DecorteChris VervaetValérie Vanhoorne

Semi-crystalline materials for pharmaceutical fused filament fabrication : dissolution and porosity

Silke HenryMark CarrollKeir N. MurphyLaurens LeysDaniel MarklValérie VanhoorneChris Vervaet

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Studying the API distribution of controlled release formulations produced via continuous twin-screw wet granulation : influence of matrix former, filler and process parameters

Phaedra DenduyverChris VervaetValérie Vanhoorne

A1 Journal Article in PHARMACEUTICS

The viscosity‐enhancing effect of carob bean gum and sodium carboxymethylcellulose when added to infant formula

Kyara BaertMathieu OmbecqMyriam Van WinckelSilke HenryEline TommeleinValérie Vanhoorne

A1 Journal Article in FOOD SCIENCE & NUTRITION

Understanding powder behavior in continuous feeding : powder densification and screw layering

Sara FathollahiPauline H. M. JanssenBram BekaertDirk VanderroostValérie VanhoorneBastiaan H. J. Dickhoff

A2 Journal Article in POWDERS

2023

Co-spray drying for continuous tablet manufacturing of conventional formulations : development of a formulation platform via co-spray drying

Elisa De PauwValérie VanhoorneChris Vervaet

Elucidation of granulation mechanisms along the length of the barrel in continuous twin-screw melt granulation

Shana Van de SteeneJeroen Van RenterghemValérie VanhoorneChris VervaetAshish KumarThomas De Beer

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Evaluation of fused filament fabrication for oral solid dosage form production

Silke HenryChris VervaetValérie Vanhoorne

Exploiting common ion addition to accelerate zolpidem hemitartrate release from Eudragit EPO extrudates

Silke HenryLaure DescampsValérie VanhoorneJean Paul RemonChris Vervaet

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Fused deposition modeling (FDM) of pharmaceuticals

Silke HenryValérie VanhoorneChris Vervaet

Bookchapter in Additive manufacturing in pharmaceuticals

Identification of continuous twin-screw melt granulation mechanisms for different screw configurations, process settings and formulation

Shana Van de SteeneJeroen Van RenterghemValérie VanhoorneChris VervaetAshish KumarThomas De Beer

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Impact of material properties and process parameters on tablet quality in a continuous direct compression line

Pauline H.M. JanssenSara FathollahiBram BekaertDirk VanderroostTimo RoelofsValérie VanhoorneChris VervaetBastiaan H.J. Dickhoff

A1 Journal Article in POWDER TECHNOLOGY

Influence of formulation variables on the processability and properties of tablets manufactured by fused deposition modelling

Joana MacedoValérie VanhoorneChris VervaetJoão F. Pinto

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Smart hydrogels delivered by high pressure aerosolization can prevent peritoneal adhesions

Helena BraetPeter-Paul FransenYong ChenSimon Van HerckRemco MariënValérie VanhoorneWim CeelenAnnemieke MadderSteven BalletRichard Hoogenboom et al.

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

Solvent electrospinning amorphous solid dispersions with high itraconazole, celecoxib, mebendazole and fenofibrate drug loading and release potential

Jana BecelaereOlmo FrateurElla SchoolaertValérie VanhoorneDagmar D'hoogeChris VervaetRichard HoogenboomKaren De Clerck

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

The effect of particle size on the sublimation behavior of butylhydroxytoluene as antioxidant in tablets during storage and coating

Milan DecorteNiloofar Moazami GoudarziMatthieu BooneBen Van HoveFlorentina-Maria PredaEllen VerheyenChris VervaetValérie Vanhoorne

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Visualization of the granule temperature using thermal imaging to improve understanding of the granulation mechanism in continuous twin-screw melt granulation

Shana Van de SteeneJeroen Van RenterghemValérie VanhoorneChris VervaetAshish KumarThomas De Beer

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

2022

Advances in twin-screw granulation

Valérie VanhoorneAshish Kumar

Editorial material

Continuous direct compression: development of an empirical predictive model and challenges regarding PAT implementation

Bram BekaertB. Van SnickKenny PandelaereJ. DhondtG. Di PretoroThomas De BeerChris VervaetValérie Vanhoorne

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS-X

Effect of feed frame on lubricant sensitivity during upscaling from a compaction simulator to a rotary tablet press

Cedrine de BackereThomas De BeerChris VervaetValérie Vanhoorne

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Formation of delta-mannitol by co-spray drying : enhancing the tabletability of paracetamol/mannitol formulations

Elisa De PauwChris VervaetValérie Vanhoorne

A1 Journal Article in JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY

Impact of alternative lubricants on process and tablet quality for direct compression

Cedrine de BackereJulian QuodbachThomas De BeerChris VervaetValérie Vanhoorne

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Impact of blend properties and process variables on the blending performance

Bram BekaertW. GrymonpréA. NovikovaChris VervaetValérie Vanhoorne

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Impact of lubrication on process and tablet quality in a direct compression process

Cedrine de BackereChris VervaetValérie Vanhoorne

In-depth analysis of the long-term processability of materials during continuous feeding

Bram BekaertB. Van SnickK. PandelaereJ. DhondtG. Di PretoroThomas De BeerChris VervaetValérie Vanhoorne

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Poly(2-alkyl-2-oxazoline)s : a polymer platform to sustain the release from tablets with a high drug loading

Aseel SamaroMaarten VergaelenMartin PurinoAli TigrineVictor Retamero De La RosaNiloofar Moazami GoudarziMatthieu BooneValérie VanhoorneRichard HoogenboomChris Vervaet

A1 Journal Article in MATERIALS TODAY BIO

Stable amorphous solid dispersion of flubendazole with high loading via electrospinning

Jana BecelaereElias Van Den BroeckElla SchoolaertValérie VanhoorneJoachim Van GuyseMaarten VergaelenSander BorgmansKarolien CreemersVeronique Van SpeybroeckChris Vervaet et al.

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

The effect of binder types on the breakage and drying behavior of granules in a semi-continuous fluid bed dryer after twin screw wet granulation

Lise VandeviverePhaedra DenduyverChristoph PortierO. HäuslerThomas De BeerChris VervaetValérie Vanhoorne

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

The precision and accuracy of 3D printing of tablets by fused deposition modelling

Joana MacedoNuno F. da CostaValérie VanhoorneChris VervaetJoão F. Pinto

A1 Journal Article in JOURNAL OF PHARMACEUTICAL SCIENCES

2021

Can filaments, pellets and powder be used as feedstock to produce highly drug-loaded ethylene-vinyl acetate 3D printed tablets using extrusion-based additive manufacturing?

Aseel SamaroBahaa ShaqourNiloofar Moazami GoudarziMichael GhijsLudwig CardonMatthieu BooneBart VerleijeKoen BeyersValérie VanhoornePaul Cos et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Continuous direct compression : improved process knowledge about the feeding and blending unit operation

Bram BekaertChris VervaetValérie Vanhoorne

Continuous granulation

Chris VervaetThomas De BeerValérie Vanhoorne

Bookchapter in Handbook of pharmaceutical granulation technology

Continuous twin screw granulation : a review of recent progress and opportunities in formulation and equipment design

Christoph PortierChris VervaetValérie Vanhoorne

A1 Journal Article in PHARMACEUTICS

Continuous twin screw granulation : impact of microcrystalline cellulose batch-to-batch variability during granulation and drying : a QbD approach

Christoph PortierTamas VighGiustino Di PretoroJan LeysDidier KlingeleersThomas De BeerChris VervaetValérie Vanhoorne

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS-X

Determination of a quantitative relationship between material properties, process settings and screw feeding behavior via multivariate data-analysis

Bram BekaertL. PenneW. GrymonpréB. Van SnickJ. DhondtJ. BoeckxJ. VogeleerThomas De BeerChris VervaetValérie Vanhoorne

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Development of a 3D-printed dosing platform to aid in zolpidem withdrawal therapy

Silke HenryLien De VadderMilan DecorteSusanna FranciaMagali Van SteenkisteJan SaevelsValérie VanhoorneChris Vervaet

A1 Journal Article in PHARMACEUTICS

Effect of binder type and lubrication method on the binder efficacy for direct compression

Cedrine de BackereThomas De BeerChris VervaetValérie Vanhoorne

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Evaluation of torque as an in-process control for granule size during twin-screw wet granulation

Alexander RyckaertFanny StaufferA. FunkeD. DjuricValérie VanhoorneChris VervaetThomas De Beer

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Extrusion-based 3D printing of oral solid dosage forms : material requirements and equipment dependencies

Silke HenryAseel SamaroFlavio H. MarchesiniBahaa ShaqourJ. MacedoValérie VanhoorneChris Vervaet

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Improved process and formulation understanding during continuous twin screw wet granulation and downstream processing

Christoph PortierChris VervaetValérie Vanhoorne

Influence of print settings on the critical quality attributes of extrusion-based 3D-printed caplets : a quality-by-design approach

Silke HenryLotte De WeverValérie VanhoorneThomas De BeerChris Vervaet

A1 Journal Article in PHARMACEUTICS

Innovative applications of hot-melt extrusion and additive manufacturing for the development of oral solid dosage forms

Aseel SamaroChris VervaetValérie Vanhoorne

Melt granulation

Shana Van de SteeneValérie VanhoorneChris VervaetThomas De Beer

Bookchapter in Handbook of pharmaceutical granulation technology

The impact of binders on formulation design in a continuous pharmaceutical manufacturing process based on twin screw wet granulation

Lise VandevivereChris VervaetValérie Vanhoorne

2020

Comparative pharmacokinetics of imepitoin after oral and rectal administration in healthy dogs

Valentine MartléMathias DevreeseSaskia RauchLuc Van HamSiska CroubelsValérie VanhoorneChris VervaetSofie Bhatti

A1 Journal Article in VETERINARY JOURNAL

Continuous twin screw granulation : a complex interplay between formulation properties, process settings and screw design

Christoph PortierKenny PandelaereUrbain DelaetTamas VighGiustino Di PretoroThomas De BeerChris VervaetValérie Vanhoorne

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Continuous twin screw granulation : impact of binder addition method and surfactants on granulation of a high-dosed, poorly soluble API

Christoph PortierTamas VighGiustino Di PretoroThomas De BeerChris VervaetValérie Vanhoorne

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Continuous twin screw granulation : influence of process and formulation variables on granule quality attributes of model formulations

Christoph PortierKenny PandelaereUrbain DelaetTamas VighAshish KumarGiustino Di PretoroThomas De BeerChris VervaetValérie Vanhoorne

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Continuous twin screw granulation : robustness of lactose/MCC-based formulations

Christoph PortierCharlotte De VriendtTamas VighGiustino Di PretoroThomas De BeerChris VervaetValérie Vanhoorne

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Delta-mannitol to enable continuous twin-screw granulation of a highly dosed, poorly compactable formulation

Valérie VanhoorneRuben AlmeyThomas De BeerChris Vervaet

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Evaluation of an external lubrication system implemented in a compaction simulator

Cedrine de BackereThomas De BeerChris VervaetValérie Vanhoorne

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

In-line temperature measurement to improve the understanding of the wetting phase in twin-screw wet granulation and its use in process development

Fanny StaufferAlexander RyckaertValérie VanhoorneDaan Van HauwermeirenAdrian FunkeDejan DjuricChris VervaetIngmar NopensThomas De Beer

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Influence of binder attributes on binder effectiveness in a continuous twin screw wet granulation process via wet and dry binder addition

Lise VandeviverePhaedra DenduyverChristoph PortierOlaf HäuslerThomas De BeerChris VervaetValérie Vanhoorne

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Prilling of API/fatty acid suspensions : an innovative pharmaceutical production technique for multiparticulate dosage forms

Elien De ConinckChris VervaetValérie Vanhoorne

Prilling of API/fatty acid suspensions : screening of additives for drug release modification

Elien De ConinckValérie VanhoorneMatthieu BooneG Van AsscheBruno De GeestThomas De BeerChris Vervaet

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Processability of poly(vinyl alcohol) based filaments with paracetamol prepared by hot-melt extrusion for additive manufacturing

Joana MacedoAseel SamaroValérie VanhoorneChris VervaetJoao Pinto

A1 Journal Article in JOURNAL OF PHARMACEUTICAL SCIENCES

Recent progress in continuous manufacturing of oral solid dosage forms

Valérie VanhoorneChris Vervaet

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Screening of pharmaceutical polymers for Extrusion-Based Additive Manufacturing of patient-tailored tablets

Aseel SamaroPauline JanssensValérie VanhoorneJeroen Van RenterghemMia EeckhoutLudwig CardonThomas De BeerChris Vervaet

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Viscosity of API/fatty acid suspensions : pitfalls during analysis

Elien De ConinckFlavio H. MarchesiniValérie VanhoorneThomas De BeerChris Vervaet

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

2019

A multivariate approach to predict the volumetric and gravimetric feeding behavior of a low feed rate feeder based on raw material properties

Nils BostijnJens DhondtAlexander RyckaertEdina SzabóW DhondtBernd Van SnickValérie VanhoorneChris VervaetThomas De Beer

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Evaluation of an in-line NIR spectroscopic method for the determination of the residence time in a tablet press

Fien De LeersnyderValérie VanhoorneAshish KumarChris VervaetThomas De Beer

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Impact of material properties and process variables on the residence time distribution in twin screw feeding equipment

Bernd Van SnickAshish KumarMaxim VerstraetenKenny PandelaereJens DhondtG Di PretoroThomas De BeerChris VervaetValérie Vanhoorne

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Managing active pharmaceutical ingredient raw material variability during twin-screw blend feeding

Fanny StaufferValérie VanhoorneG PilcerP-F ChavezMA SchubertChris VervaetThomas De Beer

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Managing API raw material variability during continuous twin-screw wet granulation

Fanny StaufferValérie VanhoorneG PilcerPierre-François ChavezChris VervaetThomas De Beer

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Managing API raw material variability in a continuous manufacturing line : prediction of process robustness

Fanny StaufferValérie VanhoorneG PilcerPierre-François ChavezChris VervaetThomas De Beer

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Modeling of semicontinuous fluid bed drying of pharmaceutical granules with respect to granule size

Michael GhijsElisabeth SchäferAshish KumarPhilippe CappuynsIvo Van AsscheFien De LeersnyderValérie VanhoorneThomas De BeerIngmar Nopens

A1 Journal Article in JOURNAL OF PHARMACEUTICAL SCIENCES

Native starch as in situ binder for continuous twin screw wet granulation

Lise VandevivereChristoph PortierValérie VanhoorneOlaf HäuslerDenis SimonThomas De BeerChris Vervaet

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Pectin-bioactive glass self-gelling, injectable composites with high antibacterial activity

Timothy DouglasMichal DziadekJosefien SchietseMatthieu BooneHeidi DeclercqTom CoenyeValérie VanhoorneChris VervaetLieve BalcaenMaria Buchweitz et al.

A1 Journal Article in CARBOHYDRATE POLYMERS

Pharmaceutical compounding of orphan active ingredients in Belgium : how community and hospital pharmacists can address the needs of patients with rare diseases

Valérie VanhoorneE PeetersInge Van TongelenKoen BousseryEvelien WynendaeleBart De SpiegeleerJean Paul RemonChris Vervaet

A1 Journal Article in ORPHANET JOURNAL OF RARE DISEASES

Prilling of API/fatty acid suspensions : processability and characterisation

Elien De ConinckValérie VanhoorneAhmed ElmahdyMatthieu BooneG Van AsscheD MarklBruno De GeestThomas De BeerChris Vervaet

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

2018

3D printing of high drug loaded dosage forms using thermoplastic polyurethanes

Glenn VerstraeteAseel SamaroWouter GrymonpréValérie VanhoorneBernd Van SnickMatthieu BooneTom HellemansLuc Van HoorebekeJean Paul RemonChris Vervaet

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

A multivariate raw material property database to facilitate drug product development and enable in-silico design of pharmaceutical dry powder processes

Bernd Van SnickJens DhondtKenny PandelaereJohny BertelsRoel MertensDidier KlingeleersGiustino Di PretoroJean Paul RemonChris VervaetThomas De Beer et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Breakage and drying behaviour of granules in a continuous fluid bed dryer : influence of process parameters and wet granule transfer

Fien De LeersnyderValérie VanhoorneH BekaertJurgen VercruysseMichael GhijsNils BostijnMaxim VerstraetenP CappuynsI Van AsscheY Vander Heyden et al.

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Development and validation of an in-line NIR spectroscopic method for continuous blend potency determination in the feed frame of a tablet press

Fien De LeersnyderElisabeth PeetersHasna DjalabiValérie VanhoorneBernd Van SnickKe HongStephen HammondAngela Yang LiuEric ZiemonsChris Vervaet et al.

A1 Journal Article in JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Downscaling of the tableting process : feasibility of miniaturized forced feeders on a high-speed rotary tablet press

Wouter GrymonpréBarbora Blahova PrudilovaValérie VanhoorneBernd Van SnickFrederik DetobelJean Paul RemonThomas De BeerChris Vervaet

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Downstream processing from melt granulation towards tablets : in-depth analysis of a continuous twin-screw melt granulation process using polymeric binders

Wouter GrymonpréGlenn VerstraeteValérie VanhoorneJean Paul RemonThomas De BeerChris Vervaet

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Humans significantly metabolize and excrete the mycotoxin deoxynivalenol and its modified form deoxynivalenol-3-glucoside within 24 hours

Arnau Vidal CorominasLiesel ClaeysMarcel MengelersValérie VanhoorneChris VervaetBart HuybrechtsSarah De SaegerMarthe De Boevre

A1 Journal Article in SCIENTIFIC REPORTS

Impact of blend properties on die filling during tableting

Bernd Van SnickWouter GrymonpréJens DhondtKenny PandelaereG Di PretoroJean Paul RemonThomas De BeerChris VervaetValérie Vanhoorne

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Novel injectable gellan gum hydrogel composites incorporating Zn- and Sr-enriched bioactive glass microparticles : high-resolution X-ray microcomputed tomography, antibacterial and in vitro testing

Timothy DouglasMichal DziadekSvetlana GorodzhaJana LiskovaGilles BrackmanValérie VanhoorneChris VervaetLieve BalcaenMaria del Rosario Florez GarciaAldo R Boccaccini et al.

A1 Journal Article in JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE

Novel self-gelling injectable hydrogel/alpha-tricalcium phosphate composites for bone regeneration : physiochemical and microcomputer tomographical characterization

Timothy DouglasJosefien SchietseAneta ZimaSvetlana GorodzhaBogdan ParakhonskiyDmitry KhalenkowRoman ShkarinAnna IvanovaTilo BaumbachVenera Weinhardt et al.

A1 Journal Article in JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Optimizing feed frame design and tableting process parameters to increase die-filling uniformity on a high-speed rotary tablet press

Wouter GrymonpréValérie VanhoorneBernd Van SnickBarbora Blahova PrudilovaFrederik DetobelJean Paul RemonThomas De BeerChris Vervaet

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Piecewise linear fitting in dynamic micro-CT

Marjolein HeyndrickxMatthieu BooneThomas De SchryverTom BultreysWannes GoethalsGlenn VerstraeteValérie VanhoorneLuc Van Hoorebeke

A1 Journal Article in MATERIALS CHARACTERIZATION

Raw material variability of an active pharmaceutical ingredient and its relevance for processability in secondary continuous pharmaceutical manufacturing

Fanny StaufferValérie VanhoorneG PilcerP-F ChavezS RomeMA SchubertL AertsThomas De Beer

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

The relevance of shear, sedimentation and diffusion during spin freezing, as potential first step of a continuous freeze-drying process for unit doses

Joris LammensSéverine MortierLaurens De MeyerBrecht VanbillemontPieter-Jan Van BockstalSimon Van HerckJos CorverIngmar NopensValérie VanhoorneBruno De Geest et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

2017

Development of a continuous direct compression platform for low-dose drug products

Bernd Van SnickJ. HolmanValérie VanhoorneAshish KumarThomas De BeerJean Paul RemonChris Vervaet

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Downstream processing from hot-melt extrusion towards tablets : a quality by design approach

Wouter GrymonpréNils BostijnSimon Van HerckGlenn VerstraeteValérie VanhoorneLutz NuhnPieter RomboutsThomas De BeerJean Paul RemonChris Vervaet

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Multivariate statistical process control of a continuous pharmaceutical twin-screw granulation and fluid bed drying process

Ana Tavares da SilvaMC SarraguçaMargot FonteyneJurgen VercruysseFien De LeersnyderValérie VanhoorneNils BostijnMaxim VerstraetenChris VervaetJean Paul Remon et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

The use of partially hydrolysed polyvinyl alcohol for the production of high drug-loaded sustained release pellets via extrusion-spheronisation and coating : in vitro and in vivo evaluation

Glenn VerstraeteWesley De JaeghereJ VercruysseWouter GrymonpréValérie VanhoorneFanny StaufferThomas De BeerAdam BezuijenJean Paul RemonChris Vervaet

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Thermoplastic polyurethane-based intravaginal rings for prophylaxis and treatment of (recurrent) bacterial vaginosis

Glenn VerstraeteL. VandenbusscheSabah KasmiLutz NuhnD. BrouckaertJeroen Van RenterghemW. GrymonpreValérie VanhoorneTom CoenyeBruno De Geest et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

2016

Continuous manufacturing of delta mannitol by cospray drying with PVP

Valérie VanhoornePieter-Jan Van BockstalBernd Van SnickE PeetersTinne MonteyneP GomesThomas De BeerJean Paul RemonChris Vervaet

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Continuous twin screw granulation of controlled release formulations with various HPMC grades

Valérie VanhoorneL JanssensJ VercruysseThomas De BeerJean Paul RemonChris Vervaet

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Development of a controlled release formulation by continuous twin screw granulation : influence of process and formulation parameters

Valérie VanhoorneBrecht VanbillemontJ VercruysseFien De LeersnyderP GomesThomas De BeerJean Paul RemonChris Vervaet

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Development of a process map : a step towards a regime map for steady-state high shear wet twin screw granulation

Ashish KumarJens DhondtJurgen VercruysseFien De LeersnyderValérie VanhoorneChris VervaetJean Paul RemonKrist V. GernaeyThomas De BeerIngmar Nopens

A1 Journal Article in POWDER TECHNOLOGY

Improved tabletability after a polymorphic transition of delta-mannitol during twin screw granulation

Valérie VanhoorneBram BekaertE PeetersThomas De BeerJean Paul RemonChris Vervaet

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Linking granulation performance with residence time and granulation liquid distributions in twin-screw granulation : an experimental investigation

Ashish KumarMaija AlakarjulaValérie VanhoorneMaunu ToiviainenFien De LeersnyderJurgen VercruysseMikko JuutiJarkko KetolainenChris VervaetJean Paul Remon et al.

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Lubricant sensitivity in function of paddle movement in the forced feeder of a high-speed tablet press

Elisabeth PeetersValérie VanhoorneChris VervaetJean Paul Remon

A1 Journal Article in DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY

Model-based process analysis in continuous manufacturing of pharmaceuticals : calibration of a fluid bed dryer model

Michael GhijsFien De LeersnyderDaan Van HauwermeirenValérie VanhoorneJurgen VercruyssePhilippe CappuynsSéverine MortierThomas De BeerKrist GernaeyIngmar Nopens

Towards continuous pharmaceutical tablet manufacturing : implementation of continuous agglomeration techniques

Valérie VanhoorneChris VervaetJean Paul Remon

2015

Conceptual framework for model-based analysis of residence time distribution in twin-screw granulation

Ashish KumarJurgen VercruysseValérie VanhoorneMaunu ToiviainenPierre-Emmanuel PanouillotMikko JuutiChris VervaetJean Paul RemonKrist V GernaeyThomas De Beer et al.

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Development of regime map for steady-state high shear wet twin-screw granulation

Ashish KumarJens DhondtJurgen VercruysseFien De LeersnyderValérie VanhoorneKrist V GernaeyThomas De BeerIngmar Nopens

Evaluation of an in-line particle imaging tool for monitoring twin-screw granulation performance

Ashish KumarJens DhondtFien De LeersnyderJurgen VercruysseValérie VanhoorneChris VervaetJean Paul RemonKrist V GernaeyThomas De BeerIngmar Nopens

A1 Journal Article in POWDER TECHNOLOGY

Experimental investigation linking granulation performance with Residence time and granulation liquid distributions in TwinScrew granulation

Ashish KumarMaija AlkarjulaValérie VanhoorneMaunu ToiviainenMikko JuutiChris VervaetJarkko KetolainenKrist V GernaeyIngmar NopensThomas De Beer

Experimental investigation of residence time, granulation liquid and granule size distributions in twin-screw granulation

Ashish KumarMaija AlakarjulaValérie VanhoorneMaunu ToiviainenMikko JuutiChris VervaetJarkko KetolainenKrist V GernaeyThomas De BeerIngmar Nopens

Experimental investigation of the link between granulation performance, residence time and granulation liquid distribution in twin-screw granulation

Ashish KumarMaija AlakarjulaValérie VanhoorneMaunu ToiviainenMikko JuutiChris VervaetJarkko KetolainenKrist V GernaeyThomas De BeerIngmar Nopens

2014

Crystal coating via spray drying to improve powder tabletability

Valérie VanhoorneElisabeth PeetersBernd Van SnickJean Paul RemonChris Vervaet

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Experimental investigation of residence time distribution in twin-screw granulation

Ashish KumarJurgen VercruysseMaunu ToiviainenPierre-Emmanuel PanouillotMikko JuutiValérie VanhoorneKrist V GernaeyThomas De BeerIngmar Nopens

Mixing and transport during pharmaceutical twin-screw wet granulation : experimental analysis via chemical imaging

Ashish KumarJurgen VercruysseMaunu ToiviainenPierre-Emmanuel PanouillotMikko JuutiValérie VanhoorneChris VervaetJean Paul RemonKrist V GernaeyThomas De Beer et al.

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Model-based analysis and experimental validation of residence time distribution in twin-screw granulation

Ashish KumarJurgen VercruysseMaunu ToiviainenPierre-Emmanuel PanouillotMikko JuutiValérie VanhoorneKrist V GernaeyThomas De BeerIngmar Nopens