Research Explorer

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Researcher

Tom Sieprath

Awards & Distinctions

15 Results

2020

Rosiglitazone protects endothelial cells from irradiation-induced mitochondrial dysfunction

Bjorn BaseletRonald B. DriesenEmma ConinxNiels BelmansTom SieprathIvo LambrichtsWinnok De VosSarah BaatoutPierre SonveauxAn Aerts

A1 Journal Article in FRONTIERS IN PHARMACOLOGY

2018

Oral microbiota reduce wound healing capacity of epithelial monolayers, irrespective of the presence of 5-fluorouracil

Eline VanlanckerBarbara VanhoeckeTom SieprathJanie BourgeoisAnnelore BeteramsBarbara De MoerlooseWinnok De VosTom Van de Wiele

A1 Journal Article in EXPERIMENTAL BIOLOGY AND MEDICINE

2017

Cellular redox profiling using high-content microscopy

Tom SieprathTobias CorneJoke RobijnsWerner JH KoopmanWinnok De Vos

A1 Journal Article in JOVE-JOURNAL OF VISUALIZED EXPERIMENTS

Deregulation of focal adhesion formation and cytoskeletal tension due to loss of A-type lamins

Tobias CorneTom SieprathJonathan VandenbusscheDanahe MohammedMariska te LindertKris GevaertSylvain GabrieleKatarina WolfWinnok De Vos

A1 Journal Article in CELL ADHESION & MIGRATION

Exploring the role of A-type lamins in cellular oxidative stress

Tom SieprathWinnok De VosEls Van Damme

2016

In silico synchronization reveals regulators of nuclear ruptures in lamin A/C deficient model cells

J RobijnsF MolenberghsTom SieprathTobias CorneM VerschuurenWinnok De Vos

A1 Journal Article in SCIENTIFIC REPORTS

Integrated high-content quantification of intracellular ROS levels and mitochondrial morphofunction

Tom SieprathTobias CornePeter HGM WillemsWerner JH KoopmanWinnok De Vos

A1 Journal Article in Advances in Anatomy Embryology and Cell Biology

2015

Quantitative proteomics reveals altered expression of actin binding proteins after LMNA knockdown in human dermal fibroblasts

Tobias CorneTom SieprathJonathan VandenbusscheKris GevaertWinnok De Vos

Sustained accumulation of prelamin A and depletion of lamin A/C both cause oxidative stress and mitochondrial dysfunction but induce different cell fates

Tom SieprathTobias CorneMarco NooteboomCharlotte GrootaertAndreja RajkovicBenjamin BuysschaertJoke RobijnsJos LV BroersFrans CS RamaekersWerner JH Koopman et al.

A1 Journal Article in NUCLEUS

2014

Chemically and genetically induced accumulation of farnesylated prelamin A differentially affect oxidative stress and mitochondrial potential

Tom SieprathTobias CorneWerner J KoopmanPeter H WillemsWinnok De Vos

High-content analysis of cellular oxidative stress

Tom SieprathTobias CorneWerner J KoopmanPeter H WillemsWinnok De Vos

Quantitative proteomics reveals differential effects of ZMPSTE24 and LMNA knockdown on human fibroblasts

Tobias CorneTom SieprathJonathan VandenbusscheKris GevaertWinnok De Vos

2013

Mimicking laminopathies with model cell lines

Tobias CorneTom SieprathWinnok De Vos

2012

Lamins as mediators of oxidative stress

Tom SieprathRabih DarwicheWinnok De Vos

A1 Journal Article in BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Perturbation of lamin A maturation alters oxidative stress response in human fibroblasts

Tom SieprathWerner J KoopmanPeter H WillemsWinnok De Vos