Research Explorer

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Researcher

Tom Delanghe

Publications & Research Data

Awards & Distinctions

13 Results

2025

ATG9A-mediated autophagy prevents inflammatory skin disease by limiting TNFR1-driven STING activation and ZBP1-dependent cell death

Dario PriemJon HuygheBarbara GilbertSimon VerdonckTom DelangheBruno VerstraetenEsther HostePeter VandenabeeleJonathan MaelfaitGeert van Loo et al.

A1 Journal Article in IMMUNITY

Primidone : a clinically promising candidate for the treatment of psoriasis

Theresa RiebelingBenedikt KolbrinkRebecca PhilippsenEileen DahlkeTom DelangheFranziska TheiligAgatha SchwarzRoland SchmittMathieu BertrandUlrich Kunzendorf et al.

A1 Journal Article in CELL DEATH DISCOVERY

TAB2 controls a TAK1-independent cell death checkpoint at the level of TNFR1 complex II in the TNF pathway

Tom DelangheMike VadiAnnelore HaemsLisa WijnsInge BruggemanJon HuygheDario PriemPeter VandenabeeleMathieu Bertrand

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

2023

NINJ1 is activated by cell swelling to regulate plasma membrane permeabilization during regulated necrosis

Yves DondelingerDario PriemJon HuygheTom DelanghePeter VandenabeeleMathieu Bertrand

A1 Journal Article in CELL DEATH & DISEASE

RIPK1 kinase-dependent inflammation and cell death contribute to the pathogenesis of COPD

Hannelore Van EeckhoutteChantal DonovanRichard Y. KimThomas M. ConlonMeshal AnsariHaroon KhanRanjith JayaramanNicole G. HansbroYves DondelingerTom Delanghe et al.

A1 Journal Article in EUROPEAN RESPIRATORY JOURNAL

2022

The Impact of RIPK1 Kinase Inhibition on Atherogenesis: A Genetic and a Pharmacological Approach

Pauline PuylaertIsabelle CoornaertCedric H. G. NeutelYves DondelingerTom DelangheMathieu BertrandPieter-Jan GunsGuido R. Y. De MeyerWim Martinet

A1 Journal Article in BIOMEDICINES

2021

Antioxidant and food additive BHA prevents TNF cytotoxicity by acting as a direct RIPK1 inhibitor

Tom DelangheJon HuygheSeungheon LeeDario PriemSamya Van CoillieBarbara GilbertSze Men ChoiPeter VandenabeeleAlexei DegterevGregory D. Cuny et al.

A1 Journal Article in CELL DEATH & DISEASE

Unraveling the role of RIPK1 phosphorylation in TNF-mediated cell death and inflammation

Tom DelangheMathieu BertrandYves Dondelinger

2020

Autophosphorylation at serine 166 regulates RIP kinase 1-mediated cell death and inflammation

Lucie LaurienMasahiro NagataHannah SchünkeTom DelangheJanica L. WiedersteinSnehlata KumariRobin SchwarzerTeresa CoronaMarcus KrügerMathieu Bertrand et al.

A1 Journal Article in NATURE COMMUNICATIONS

RIPK1 kinase-dependent death : a symphony of phosphorylation events

Tom DelangheYves DondelingerMathieu Bertrand

A1 Journal Article in TRENDS IN CELL BIOLOGY

2019

Serine 25 phosphorylation inhibits RIPK1 kinase-dependent cell death in models of infection and inflammation

Yves DondelingerTom DelangheDario PriemMeghan A Wynosky-DolfiDaniel SorobeteaDiego Rojas RiveraPiero GiansantiRia RoelandtJulia GropengiesserKlaus Ruckdeschel et al.

A1 Journal Article in NATURE COMMUNICATIONS

2018

MK2 puts an additional brake on RIPK1 cytotoxic potential

Yves DondelingerTom DelangheMathieu Bertrand

Editorial material

2017

MK2 phosphorylation of RIPK1 regulates TNF-mediated cell death

Yves DondelingerTom DelangheDiego Rojas RiveraDario PriemTinneke DelvaeyeInge BruggemanFranky Van HerreweghePeter VandenabeeleMathieu Bertrand

A1 Journal Article in NATURE CELL BIOLOGY