Research Explorer

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Researcher

Tino Hochepied

Publications & Research Data

Awards & Distinctions

64 Results

2025

A crucial role of the malate aspartate shuttle in metabolic reprogramming in TNF-induced SIRS

Louise NuyttensMarah HeyerickMaxime RoesElise MoensCéline Van DenderCharlotte WallaeysTino HochepiedSteven TimmermansJolien VandewalleClaude Libert

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Generation of a new Paneth cell-specific Cre-recombinase transgenic mouse line

Natalia Garcia GonzalezCharlotte WallaeysWendy ToussaintTino HochepiedSylviane DewaeleSomara De BeulRobin Van LokeJolien VandewalleSteven TimmermansClaude Libert

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

2024

Challenging the conventional wisdom : re-evaluating smpd3's role in extracellular vesicle biogenesis

Marlies BurgelmanPieter DujardinAnthony WillemsTino HochepiedGriet Van ImschootElien Van WonterghemLien Van HoeckeCharysse VandendriesscheRoosmarijn Vandenbroucke

A2 Journal Article in JOURNAL OF EXTRACELLULAR BIOLOGY

MeCP2 binds to methylated DNA independently of phase separation and heterochromatin organisation

Raphael PantierMegan BrownSicheng HanKatie PatonStephen MeekThomas MontavonNicholas ShukeirToni MchughDavid A. KellyTino Hochepied et al.

A1 Journal Article in NATURE COMMUNICATIONS

2023

OTULIN protects the intestinal epithelium from apoptosis during inflammation and infection

Lien VerboomChristopher AndersonMaude JansIoanna PettaGillian BlanckeArne MartensMozes SzeTino HochepiedKodi RavichandranLars Vereecke et al.

A1 Journal Article in CELL DEATH & DISEASE

Protein citrullination and NET formation do not contribute to the pathology of A20/TNFAIP3 mutant mice

Karel Van DammePieter HertensArne MartensElisabeth GilisDario PriemInge BruggemanAmelie FossoulJozefien DeclercqHelena Catharine AegerterAndy Wullaert et al.

A1 Journal Article in SCIENTIFIC REPORTS

Sterile triggers drive joint inflammation in TNF‐ and IL-1β‐dependent mouse arthritis models

Alexandra ThiranIoanna PettaGillian BlanckeMarie ThorpGuillaume PlanckaertMaude JansVanessa AndriesKorneel BarbryElisabeth GilisJulie Coudenys et al.

A1 Journal Article in EMBO MOLECULAR MEDICINE

The impact of hepatocyte-specific deletion of hypoxia-inducible factors on the development of polymicrobial sepsis with focus on GR and PPARα function

Tineke VanderhaeghenSteven TimmermansMelanie EggermontDeepika WattsJolien VandewalleCharlotte WallaeysLouise NuyttensJoyca De TemmermanTino HochepiedSylviane Dewaele et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

2022

A20 controls RANK-dependent osteoclast formation and bone physiology

Arne MartensPieter HertensDario PriemVagelis RinotasTheodore MeletakosMeropi GennadiLisette Van HoveEls LouagieJulie CoudenysAmélie De Muynck et al.

A1 Journal Article in EMBO REPORTS

Context-dependent effects of IL-2 rewire immunity into distinct cellular circuits

Carly E. WhyteKailash SinghOliver T. BurtonMeryem AloulouLubna KouserRafael Valente VeigaAmy DashwoodHanneke OkkenhaugSamira BenaddaAlena Moudra et al.

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

Innovative mouse models for the tumor suppressor activity of protocadherin-10 isoforms

Irene KleinbergerEllen SandersKatrien StaesMarleen Van TroysShinji HiranoTino HochepiedKelly LemeireLiesbet MartensChristophe AmpeFrans Van Roy

A1 Journal Article in BMC CANCER

Myb drives B-cell neoplasms and myeloid malignancies in vivo

Tim PietersAndré Pedro Pinto De AlmeidaSara T'SasKelly LemeireTino HochepiedGeert BerxAlex KentsisSteven GoossensPieter Van Vlierberghe

A1 Journal Article in BLOOD ADVANCES

Point mutation I634A in the glucocorticoid receptor causes embryonic lethality by reduced ligand binding

Steven TimmermansNicolette J.D. VerhoogKelly Van LooverenSylviane DewaeleTino HochepiedMelanie EggermontBarbara GilbertAnne Boerema-de MunckTineke VanderhaeghenJoke Vanden Berghe et al.

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Single-cell genome sequencing of human neurons identifies somatic point mutation and indel enrichment in regulatory elements

Lovelace J. LuquetteMichael B. MillerZinan ZhouCraig L. BohrsonYifan ZhaoHu JinDoga GulhanJavier GanzSara BizzottoSamantha Kirkham et al.

A1 Journal Article in NATURE GENETICS

2021

A new transgenic mouse line for imaging mitochondrial calcium signals

Nelly RedolfiElisa GreottiGiulia ZanettiTino HochepiedCristina FasolatoDiana PendinTullio Pozzan

A2 Journal Article in FUNCTION

Cyclin D2 overexpression drives B1a-derived MCL-like lymphoma in mice

Tim PietersSara T'SasStijn VanheeAndré Pedro Pinto De AlmeidaYasmine DriegeJuliette RoelsWouter Van LoockeWillem DaneelsMathijs BaensArnaud Marchand et al.

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

Fibrotic enzymes modulate wound-induced skin tumorigenesis

Lisette Van HoveKim LecomteJana RoelsNiels VandammeHanna-Kaisa VikkulaIsabelle HoorensKatia OngenaeTino HochepiedGiacomo DonatiYvan Saeys et al.

A1 Journal Article in EMBO REPORTS

OTULIN maintains skin homeostasis by controlling keratinocyte death and stem cell identity

Esther HosteKim LecomteKarl AnnusverNiels VandammeJana RoelsSophia MaschalidiLien VerboomHanna-Kaisa VikkulaMozes SzeLisette Van Hove et al.

A1 Journal Article in NATURE COMMUNICATIONS

Response to correspondence on 'Reproducibility of CRISPR-Cas9 methods for generation of conditional mouse alleles : a multi-center evaluation'

Channabasavaiah B. GurumurthyAidan R. O'BrienRolen M. QuadrosJr. Adams, JohnPilar AlcaideShinya AyabeJohnathan BallardSurinder K. BatraMarie-Claude BeauchampKathleen A. Becker et al.

A1 Journal Article in GENOME BIOLOGY

Ring finger protein 213 assembles into a sensor for ISGylated proteins with antimicrobial activity

Fabien Henri TheryLia MartinaCaroline AsselmanHeidi RepoY ZhangKoen SedeynGeorgios MoschonasC BredowQW TeoJ Zhang et al.

A1 Journal Article in NATURE COMMUNICATIONS

2020

MALT1 targeting suppresses CARD14‐induced psoriatic dermatitis in mice

Elien Van NuffelJens StaalGriet BaudeletMira HaegmanYasmine DriegeTino HochepiedInna AfoninaRudi Beyaert

A1 Journal Article in EMBO REPORTS

Two distinct ubiquitin-binding motifs in A20 mediate its anti-inflammatory and cell-protective activities

Arne MartensDario PriemEsther HosteJessica VettersSofie RennenLeen CatrysseSofie VoetLaura DeelenMozes SzeHanna-Kaisa Vikkula et al.

A1 Journal Article in NATURE IMMUNOLOGY

Zinc inhibits lethal inflammatory shock by preventing microbe-induced interferon signature in intestinal epithelium

Jolien SouffriauSteven TimmermansTineke VanderhaeghenCharlotte WallaeysKelly Van LooverenLindsy AelbrechtSylviane DewaeleJolien VandewalleEvy GoossensSerge Verbanck et al.

A1 Journal Article in EMBO MOLECULAR MEDICINE

2019

A new mouse model to study the role of ectopic Nanos3 expression in cancer

Vanessa AndriesEvi De KeuckelaereKatrien StaesTino HochepiedJoachim TaminauKelly LemeirePhilippe BirembautGeert BerxFrans Van Roy

A1 Journal Article in BMC CANCER

MALT1 proteolytic activity suppresses autoimmunity in a T cell intrinsic manner

Annelies DemeyerIoannis SkordosYasmine DriegeMarja KreikeTino HochepiedMathijs BaensJens StaalRudi Beyaert

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Novel strategy for rapid functional in vivo validation of oncogenic drivers in haematological malignancies

Tim PietersSara T'SasLisa DemoenAndré Pedro Pinto De AlmeidaLieven HaenebalckeFilip MatthijssensKelly LemeireJinke D'HontFrédérique VanrockeghemTino Hochepied et al.

A1 Journal Article in SCIENTIFIC REPORTS

Reproducibility of CRISPR-Cas9 methods for generation of conditional mouse alleles : a multi-center evaluation

Channabasavaiah B. GurumurthyAidan R O'BrienRolen M QuadrosJohn AdamsPilar AlcaideShinya AyabeJohnathan BallardSurinder K BatraMarie-Claude BeauchampKathleen A Becker et al.

A1 Journal Article in GENOME BIOLOGY

2018

A knock-in/knock-out mouse model of HSPB8-associated distal hereditary motor neuropathy and myopathy reveals toxic gain-of-function of mutant Hspb8

Delphine BouhyManisha JunejaIstvan KatonaAnne HolmgrenBob AsselberghVicky De WinterTino HochepiedSteven GoossensJody J HaighClaude Libert et al.

A1 Journal Article in ACTA NEUROPATHOLOGICA

DMRT5 together with DMRT3 directly controls hippocampus development and neocortical area map formation

Sarah De ClercqMarc KeruzoreElodie DesmarisCharlotte PollartStavroula AssimacopoulosJulie PreillonSabrina AscenzoClinton K MatsonMelody LeeXinsheng Nan et al.

A1 Journal Article in CEREBRAL CORTEX

Genetic mapping of species differences via in vitro crosses in mouse embryonic stem cells

Stefano LazzaranoMarek KuckaJoao PL CastroRonald NaumannPaloma MedinaMichael NC FletcherRebecka WombacherJoost GribnauTino HochepiedMarc Van Montagu et al.

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

2017

Caspase-1 engagement and TLR-induced c-FLIP expression suppress ASC/caspase-8-dependent apoptosis by inflammasome sensors NLRP1b and NLRC4

Nina Van OpdenboschHanne Van GorpMaarten VerdoncktPedro Henrique Viana SaavedraNathalia Moraes de VasconcelosAmanda GonçalvesLieselotte Vande WalleDieter DemonMagdalena MatusiakFilip Van Hauwermeiren et al.

A1 Journal Article in CELL REPORTS

Elevated ΔNp63α levels facilitate epidermal and biliary oncogenic transformation

Michael DevosBarbara GilbertGeertrui DeneckerKirsten LeursConor Mc GuireKelly LemeireTino HochepiedMarnik VuylstekeJo LambertCaroline Van den Broecke et al.

A1 Journal Article in JOURNAL OF INVESTIGATIVE DERMATOLOGY

Structure-function studies in mouse embryonic stem cells using recombinase-mediated cassette exchange

Tim PietersLieven HaenebalckeKenneth BruneelNiels VandammeTino HochepiedJolanda van HengelDagmar WirthGeert BerxJody J HaighFrans Van Roy et al.

A1 Journal Article in JOVE-JOURNAL OF VISUALIZED EXPERIMENTS

2016

Characterization of new transgenic mouse models for two Charcot-Marie-tooth-causing HspB1 mutations using the Rosa26 locus

Delphine BouhyThomas GeuensVicky De WinterLeonardo De Almeida SouzaIstvan KatonaJoachim WeisTino HochepiedSteven GoossensJody HaighSophie Janssens et al.

A2 Journal Article in JOURNAL OF NEUROMUSCULAR DISEASES

Familial Mediterranean fever mutations lift the obligatory requirement for microtubules in Pyrin inflammasome activation

Hanne Van GorpPedro Henrique Viana SaavedraNathalia Moraes de VasconcelosNina Van OpdenboschLieselotte Vande WalleMagdalena MatusiakGiusi PrencipeAntonella InsalacoFilip Van HauwermeirenDieter Demon et al.

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fast generation of conditional ROSA26-based mouse models that recapitulate genomic events in human T-ALL

Tim PietersSteven GoossensSara T'SasLieven HaenebalckeTino HochepiedBéatrice LintermansSofie PeirsFilip MatthijssensJ HaighGeert Berx et al.

NLRP2 controls age-associated maternal fertility

Anna KuchmiyJinke D'HontTino HochepiedMohamed Lamkanfi

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

NOD-like receptor Nlrp2 is dispensable for immune signaling, but critical for efficient early embryonic development in aged oocytes

Anna KuchmiyJinke D’HontTino HochepiedMohamed Lamkanfi

Overexpression of glucocorticoid-induced leucine zipper (GILZ) increases susceptibility to imiquimod-induced psoriasis and involves cutaneous activation of TGF-β1

Elena CarcellerMarlies BallegeerJulie DeckersCarlo RiccardiStefano BruscoliTino HochepiedClaude LibertPaloma Perez

A1 Journal Article in SCIENTIFIC REPORTS

p120 Catenin-mediated stabilization of E-cadherin is essential for primitive endoderm specification

Tim PietersSteven GoossensLieven HaenebalckeVanessa AndriesAgata StryjewskaRiet De RyckeKelly LemeireTino HochepiedDanny HuylebroeckGeert Berx et al.

A1 Journal Article in PLOS GENETICS

2015

An ER-directed gelsolin nanobody targets the first step in amyloid formation in a gelsolin amyloidosis mouse model

Wouter Van OverbekeJantana WongsantichonInge EveraertAdriaan VerhelleOlivier ZwaenepoelAnantasak LoonchantaLeslie D BurtnickAriane De GanckTino HochepiedJody Haigh et al.

A1 Journal Article in HUMAN MOLECULAR GENETICS

Cardiovascular and pharmacological implications of haem-deficient NO-unresponsive soluble guanylate cyclase knock-in mice

Robrecht ThoonenAnje CauwelsKelly DecaluwéSandra GeschkaRobert E TainshJoris DelangheTino HochepiedLode De CauwerElke RoggeSofie Voet et al.

A1 Journal Article in NATURE COMMUNICATIONS

2014

Heme-deficient NO-unresponsive sGC knock-in mice: novel aspects of NO sGC signaling in cardiovascular (patho)physiology

Robrecht ThoonenEmmanuel BuysAnje CauwelsKelly DecaluwéSandra GeschkaRobert TainshJoris DelangheTino HochepiedLode De CauwerElke Rogge et al.

2013

Mice overexpressing β-1,4-galactosyltransferase I are resistant to TNF-induced inflammation and DSS-induced colitis

Valerie VanhoorenRoosmarijn VandenbrouckeSylviane DewaeleEvelien Van HammeJody HaighTino HochepiedClaude Libert

A1 Journal Article in PLOS ONE

RNF4 is required for DNA double-strand break repair in vivo

R VyasR KumarF ClermontA HelfrichtP KalevP SotiropoulouIA HendriksE RadaelliTino HochepiedC Blanpain et al.

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

The ROSA26-iPSC mouse : a conditional, inducible, and exchangeable resource for studying cellular (de)differentiation

Lieven HaenebalckeSteven GoossensPieterjan DierickxSona BartunkovaJinke D'HontKatharina HaighTino HochepiedDagmar WirthAndras NagyJody Haigh

A1 Journal Article in CELL REPORTS

2012

Efficient and user-friendly pluripotin-based derivation of mouse embryonic stem cells

Tim PietersLieven HaenebalckeTino HochepiedJinke D'HontJody HaighFrans Van RoyJolanda van Hengel

A1 Journal Article in STEM CELL REVIEWS AND REPORTS

2011

Cop1 constitutively regulates c-Jun protein stability and functions as a tumor suppressor in mice

Domenico MiglioriniSven BogaertsDieter DefeverRajesh VyasGeertrui DeneckerEnrico RadaelliAleksandra ZwolinskaVanessa DepaepeTino HochepiedWilliam C Skarnes et al.

A1 Journal Article in JOURNAL OF CLINICAL INVESTIGATION

2007

Caspase-14 protects against epidermal UVB photo-damage and water loss

Geertrui DeneckerEsther HosteBarbara GilbertTino HochepiedPetra OvaereSaskia LippensC VAN DEN BROUCKEPetra Van DammeKatharina D'HerdeJ HACHEM et al.

Caspase-14 protects against epidermal UVB photo-damage and water loss.

Geertrui DeneckerEsther HosteBarbara GilbertTino HochepiedPetra OvaereSaskia LippensC VAN DEN BROUCKEPetra Van DammeKatharina D'HerdeJ HACHEM et al.

Caspase-14 protects against epidermal UVB photodamage and water loss

Geertrui DeneckerEsther HosteBarbara GilbertTino HochepiedPetra OvaereSaskia LippensCaroline Van den broeckePetra Van DammeKatharina D'HerdeJP HACHEM et al.

A1 Journal Article in NATURE CELL BIOLOGY

2006

Role of caspase-14 in terminal differentiation of keratinocytes

Geertrui DeneckerEsther HosteBarbara GilbertTino HochepiedPetra OvaereSaskia LippensCaroline VandenbrouckeKatharina D'HerdePeter VandenabeeleWim Declercq

The wild-derived inbred mouse strain SPRET/Ei is resistant to LPS and defective in IFN-beta production

Tina MahieuJM PARKH REVETSB PASCHEA LENGELINGJan StaelensAndy WullaertIneke VanlaereTino HochepiedFrans Van Roy et al.

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

2004

Breaking the species barrier: derivation of germline-competent embryonic stem cells from Mus spretus x C57BL/6 hybrids

Tino HochepiedLuc SchoonjansJan StaelensVeerle KreemersSophie DanloyLeen PuimègeDésiré CollenFrans Van RoyClaude Libert

A1 Journal Article in STEM CELLS

Exogenous alpha-1-acid glycoprotein protects against renal ischemia-reperfusion injury by inhibition of inflammation and apoptosis

B DE VRIESSJ WALTERTGAM WOLFSTino HochepiedJ RABINAP HEERINGAJ PARKKINENClaude LibertWA BUURMAN

A1 Journal Article in TRANSPLANTATION

Response of TNF-hyporesponsive SPRET/Ei mice in models of inflammatory disorders

Jan StaelensLeen PuimègeTina MahieuGwenda PynaertTino HochepiedAnnelies VandenabeeleJohan GrootenDimitris KontoyiannisFrans Van RoyGeorge Kollias et al.

A1 Journal Article in MAMMALIAN GENOME

2003

alpha(1)-Acid glycoprotein: an acute phase protein with inflammatory and immunomodulating properties

Tino HochepiedFG BERGERH BAUMANNClaude Libert

A1 Journal Article in CYTOKINE & GROWTH FACTOR REVIEWS

2002

Mice lacking a 2-macroglobulin show an increased host defense against Gram-negative bacterial sepsis, but are more susceptible to endotoxic shock.

Tino HochepiedF VAN LEUVENClaude Libert

A1 Journal Article in EUROPEAN CYTOKINE NETWORK

Overexpression of alpha(1)-acid glycoprotein in transgenic mice leads to sensitisation to acute colitis.

Tino HochepiedAndy WullaertFG BERGERH BAUMANNPeter BrouckaertLothar SteidlerClaude Libert

A1 Journal Article in GUT

2001

Detection, characterisation and purification of a murine liver factor capable of desensitising towards the lethal activity of tumour necrosis factor.

Ben WielockxTino HochepiedJan StaelensWim Van MollePeter BrouckaertClaude Libert

A1 Journal Article in CYTOKINE

2000

Differential response of alpha(2)-macroglobulin-deficient mice in models of lethal TNF-induced inflammation.

Tino HochepiedPaul AmelootPeter BrouckaertF VAN LEUVENClaude Libert

A1 Journal Article in EUROPEAN CYTOKINE NETWORK

Involvement of the acute phase protein alpha(1)-acid glycoprotein in nonspecific resistance to a lethal Gram-negative infection.

Tino HochepiedWim Van MolleFG BERGERH BAUMANNClaude Libert

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

The major acute-phase protein, serum amyloid P component, in mice is not involved in endogenous resistance against tumor necrosis factor alpha-induced lethal hepatitis, shock, and skin necrosis.

Wim Van MolleTino HochepiedPeter BrouckaertClaude Libert

A1 Journal Article in INFECTION AND IMMUNITY

1998

High-level constitutive expression of alpha(1)-acid glycoprotein and lack of protection against tumor necrosis factor-induced lethal shock in transgenic mice.

Claude LibertTino HochepiedFG BERGERH BAUMANNWalter FiersPeter Brouckaert

A1 Journal Article in TRANSGENIC RESEARCH