Research Explorer

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Researcher

Tino Hochepied

49 Results

2021

Cyclin D2 overexpression drives B1a-derived MCL-like lymphoma in mice

Tim PietersSara T'SasStijn VanheeAndré Pedro Pinto De AlmeidaYasmine DriegeJuliette RoelsWouter Van LoockeWillem DaneelsMathijs BaensArnaud MarchandMaaike Van TrimpontFilip MatthijssensJulie MorscioKelly LemeireBéatrice LintermansLindy ReunesPatrick ChaltinFritz OffnerJo Van DorpeTino HochepiedGeert BerxRudi BeyaertJens StaalPieter Van VlierbergheSteven Goossens

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

Fibrotic enzymes modulate wound-induced skin tumorigenesis

Lisette Van HoveKim LecomteJana RoelsNiels VandammeHanna-Kaisa VikkulaIsabelle HoorensKatia OngenaeTino HochepiedGiacomo DonatiYvan SaeysSven R. QuistFiona M. WattGeert van LooEsther Hoste

A1 Journal Article in EMBO REPORTS

OTULIN maintains skin homeostasis by controlling keratinocyte death and stem cell identity

Esther HosteKim LecomteKarl AnnusverNiels VandammeJana RoelsSophia MaschalidiLien VerboomHanna-Kaisa VikkulaMozes SzeLisette Van HoveKevin VerstaenArne MartensTino HochepiedYvan SaeysKodi RavichandranMaria KasperGeert van Loo

U Journal Article in NATURE COMMUNICATIONS

Response to correspondence on 'Reproducibility of CRISPR-Cas9 methods for generation of conditional mouse alleles : a multi-center evaluation'

Channabasavaiah B. GurumurthyAidan R. O'BrienRolen M. QuadrosJr. Adams, JohnPilar AlcaideShinya AyabeJohnathan BallardSurinder K. BatraMarie-Claude BeauchampKathleen A. BeckerGuillaume BernasDavid BroughFrancisco Carrillo-SalinasWesley ChanHanying ChenRuby DawsonVictoria DeMambroJinke D'HontKatharine DibbJames D. EudyLin GanJing GaoAmy GonzalesAnyonya GunturHuiping GuoDonald W. HarmsAnne HarringtonKathryn E. HentgesNeil HumphreysShiho ImaiHideshi IshiiMizuho IwamaEric JonaschMichelle KarolakBernard KeavneyNay-Chi KhinMasamitsu KonnoYuko KotaniYayoi KunihiroImayavaramban LakshmananCatherine LarochelleCatherine B. LawrenceLin LiVolkhard LindnerXian-De LiuGloria Lopez-CastejonAndrew LoudonJenna LoweLoydie Jerome-MajeweskaTaiji MatsusakaHiromi MiuraYoshiki MiyasakaBenjamin MorpurgoKatherine MotylYo-ichi NabeshimaKoji NakadeToshiaki NakashibaKenichi NakashimaYuichi ObataSanae OgiwaraMariette OuelletLeif OxburghSandra PiltzIlka PinzMoorthy P. PonnusamyDavid RayRonald J. RedderClifford J. RosenNikki RossMark T. RuheLarisa RyzhovaAne M. SalvadorSabrina Shameen AlamRadislav SedlacekKaran SharmaChad SmithKatrien StaesLora StarrsFumihiro SugiyamaSatoru TakahashiTomohiro TanakaAndrew TraffordYoshihiro UnoLeen VanhoutteFrédérique VanrockeghemBrandon J. WillisChristian S. WrightYuko YamauchiXin YiKazuto YoshimiXuesong ZhangYu ZhangMasato OhtsukaSatyabrata DasDaniel J. GarryTino HochepiedPaul ThomasJan Parker-ThornburgAntony D. AdamsonAtsushi YoshikiJean-Francois SchmouthAndrei GolovkoWilliam R. ThompsonK. C. Kent LloydJoshua A. WoodMitra CowanTomoji MashimoSeiya MizunoHao ZhuPetr KasparekLucy LiawJoseph M. MianoGaetan Burgio

A1 Journal Article in GENOME BIOLOGY

Ring finger protein 213 assembles into a sensor for ISGylated proteins with antimicrobial activity

Fabien TheryLia MartinaCaroline AsselmanHeidi RepoY ZhangKoen SedeynGeorgios MoschonasC BredowQW TeoJ ZhangM VesselyKevin LeandroDenzel EggermontDelphine De SutterKatie BoucherTino HochepiedNele FestjensNico CallewaertXavier SaelensBart DermautKP KnobelochA BelingS SanyalL RadoshevichSven EyckermanFrancis Impens

A1 Journal Article in NATURE COMMUNICATIONS

2020

MALT1 targeting suppresses CARD14‐induced psoriatic dermatitis in mice

Elien Van NuffelJens StaalGriet BaudeletMira HaegmanYasmine DriegeTino HochepiedInna AfoninaRudi Beyaert

A1 Journal Article in EMBO REPORTS

Two distinct ubiquitin-binding motifs in A20 mediate its anti-inflammatory and cell-protective activities

Arne MartensDario PriemEsther HosteJessica VettersSofie RennenLeen CatrysseSofie VoetLaura DeelenMozes SzeHanna-Kaisa VikkulaKarolina SlowickaTino HochepiedKalliopi IliakiAndy WullaertSophie JanssensMohamed LamkanfiRudi BeyaertMarietta ArmakaMathieu BertrandGeert van Loo

A1 Journal Article in NATURE IMMUNOLOGY

Zinc inhibits lethal inflammatory shock by preventing microbe-induced interferon signature in intestinal epithelium

Jolien SouffriauSteven TimmermansTineke VanderhaeghenCharlotte WallaeysKelly Van LooverenLindsy AelbrechtSylviane DewaeleJolien VandewalleEvy GoossensSerge VerbanckFilip BoyenMelanie EggermontLindsey De CommerRiet De RyckeMichiel De BruyneRaul TitoMarlies BallegeerSofie VandevyverTiago VelhoLuis Ferreira MoitaTino HochepiedKarolien De BosscherJeroen RaesFilip Van ImmerseelRudi BeyaertClaude Libert

A1 Journal Article in EMBO MOLECULAR MEDICINE

2019

A new mouse model to study the role of ectopic Nanos3 expression in cancer

Vanessa AndriesEvi De KeuckelaereKatrien StaesTino HochepiedJoachim TaminauKelly LemeirePhilippe BirembautGeert BerxFrans Van Roy

A1 Journal Article in BMC CANCER

MALT1 proteolytic activity suppresses autoimmunity in a T cell intrinsic manner

Annelies DemeyerIoannis SkordosYasmine DriegeMarja KreikeTino HochepiedMathijs BaensJens StaalRudi Beyaert

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Novel strategy for rapid functional in vivo validation of oncogenic drivers in haematological malignancies

Tim PietersSara T'SasLisa DemoenAndré Pedro Pinto De AlmeidaLieven HaenebalckeFilip MatthijssensKelly LemeireJinke D'HontFrédérique VanrockeghemTino HochepiedBéatrice LintermansLindy ReunesTim LammensGeert BerxJody J. HaighSteven GoossensPieter Van Vlierberghe

A1 Journal Article in SCIENTIFIC REPORTS

Reproducibility of CRISPR-Cas9 methods for generation of conditional mouse alleles : a multi-center evaluation

Channabasavaiah B. GurumurthyAidan R O'BrienRolen M QuadrosJohn AdamsPilar AlcaideShinya AyabeJohnathan BallardSurinder K BatraMarie-Claude BeauchampKathleen A BeckerGuillaume BernasDavid BroughFrancisco Carrillo-SalinasWesley ChanHanying ChenRuby DawsonVictoria DeMambroJinke D'HontKatharine M DibbJames D EudyLin GanJing GaoAmy GonzalesAnyonya R GunturHuiping GuoDonald W HarmsAnne HarringtonKathryn E HentgesNeil HumphreysShiho ImaiHideshi IshiiMizuho IwamaEric JonaschMichelle KarolakBernard KeavneyNay-Chi KhinMasamitsu KonnoYuko KotaniYayoi KunihiroImayavaramban LakshmananCatherine LarochelleCatherine B. LawrenceLin LiVolkhard LindnerXian-De LiuGloria Lopez-CastejonAndrew LoudonJenna LoweLoydie A Jerome-MajewskaTaiji MatsusakaHiromi MiuraYoshiki MiyasakaBenjamin MorpurgoKatherine MotylYo-ichi NabeshimaKoji NakadeToshiaki NakashibaKenichi NakashimaYuichi ObataSanae OgiwaraMariette OuelletLeif OxburghSandra PiltzIlka PinzMoorthy P PonnusamyDavid RayRonald J RedderClifford J RosenNikki RossMark T RuheLarisa RyzhovaAne M SalvadorSabrina Shameen AlamRadislav SedlacekKaran SharmaChad SmithKatrien StaesLora StarrsFumihiro SugiyamaSatoru TakahashiTomohiro TanakaAndrew W TraffordYoshihiro UnoLeen VanhoutteFrédérique VanrockeghemBrandon J WillisChristian S WrightYuko YamauchiXin YiKazuto YoshimiXuesong ZhangYu ZhangMasato OhtsukaSatyabrata DasDaniel J GarryTino HochepiedPaul ThomasJan Parker-ThornburgAntony D AdamsonAtsushi YoshikiJean-Francois SchmouthAndrei GolovkoWilliam R ThompsonKC Kent LloydJoshua A WoodMitra CowanTomoji MashimoSeiya MizunoHao ZhuPetr KasparekLucy LiawJoseph M MianoGaetan Burgio

A1 Journal Article in GENOME BIOLOGY

2018

A knock-in/knock-out mouse model of HSPB8-associated distal hereditary motor neuropathy and myopathy reveals toxic gain-of-function of mutant Hspb8

Delphine BouhyManisha JunejaIstvan KatonaAnne HolmgrenBob AsselberghVicky De WinterTino HochepiedSteven GoossensJody J HaighClaude LibertChantal Ceuterick-de GrooteJoy IrobiJoachim WeisVincent Timmerman

A1 Journal Article in ACTA NEUROPATHOLOGICA

DMRT5 together with DMRT3 directly controls hippocampus development and neocortical area map formation

Sarah De ClercqMarc KeruzoreElodie DesmarisCharlotte PollartStavroula AssimacopoulosJulie PreillonSabrina AscenzoClinton K MatsonMelody LeeXinsheng NanMeng LiYasushi NakagawaTino HochepiedDavid ZarkowerElizabeth A GroveEric J Bellefroid

A1 Journal Article in CEREBRAL CORTEX

Genetic mapping of species differences via in vitro crosses in mouse embryonic stem cells

Stefano LazzaranoMarek KuckaJoao PL CastroRonald NaumannPaloma MedinaMichael NC FletcherRebecka WombacherJoost GribnauTino HochepiedMarc Van MontaguClaude LibertYingguang Frank Chan

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

2017

Caspase-1 engagement and TLR-induced c-FLIP expression suppress ASC/caspase-8-dependent apoptosis by inflammasome sensors NLRP1b and NLRC4

Nina Van OpdenboschHanne Van GorpMaarten VerdoncktPedro Henrique Viana SaavedraNathalia Moraes de VasconcelosAmanda GonçalvesLieselotte Vande WalleDieter DemonMagdalena MatusiakFilip Van HauwermeirenJinke D'HontTino HochepiedStefan KrautwaldThirumala-Devi KannegantiMohamed Lamkanfi

A1 Journal Article in CELL REPORTS

Elevated ΔNp63α levels facilitate epidermal and biliary oncogenic transformation

Michael DevosBarbara GilbertGeertrui DeneckerKirsten LeursConor Mc GuireKelly LemeireTino HochepiedMarnik VuylstekeJo LambertCaroline Van den BroeckeLouis LibbrechtJody HaighGeert BerxSaskia LippensPeter VandenabeeleWim Declercq

A1 Journal Article in JOURNAL OF INVESTIGATIVE DERMATOLOGY

Structure-function studies in mouse embryonic stem cells using recombinase-mediated cassette exchange

Tim PietersLieven HaenebalckeKenneth BruneelNiels VandammeTino HochepiedJolanda van HengelDagmar WirthGeert BerxJody J HaighFrans Van RoySteven Goossens

A1 Journal Article in JOVE-JOURNAL OF VISUALIZED EXPERIMENTS

2016

Characterization of new transgenic mouse models for two Charcot-Marie-tooth-causing HspB1 mutations using the Rosa26 locus

Delphine BouhyThomas GeuensVicky De WinterLeonardo De Almeida SouzaIstvan KatonaJoachim WeisTino HochepiedSteven GoossensJody HaighSophie JanssensVincent Timmerman

A2 Journal Article in JOURNAL OF NEUROMUSCULAR DISEASES

Familial Mediterranean fever mutations lift the obligatory requirement for microtubules in Pyrin inflammasome activation

Hanne Van GorpPedro Henrique Viana SaavedraNathalia Moraes de VasconcelosNina Van OpdenboschLieselotte Vande WalleMagdalena MatusiakGiusi PrencipeAntonella InsalacoFilip Van HauwermeirenDieter DemonDelfien BogaertMelissa DullaersElfride De BaereTino HochepiedJo DehoorneKarim VermaelenFilomeen HaerynckFabrizio De BenedettiMohamed Lamkanfi

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fast generation of conditional ROSA26-based mouse models that recapitulate genomic events in human T-ALL

Tim PietersSteven GoossensSara T'SasLieven HaenebalckeTino HochepiedBéatrice LintermansSofie PeirsFilip MatthijssensJ HaighGeert BerxPieter Van Vlierberghe

NLRP2 controls age-associated maternal fertility

Anna KuchmiyJinke D'HontTino HochepiedMohamed Lamkanfi

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

NOD-like receptor Nlrp2 is dispensable for immune signaling, but critical for efficient early embryonic development in aged oocytes

Anna KuchmiyJinke D’HontTino HochepiedMohamed Lamkanfi

Overexpression of glucocorticoid-induced leucine zipper (GILZ) increases susceptibility to imiquimod-induced psoriasis and involves cutaneous activation of TGF-β1

Elena CarcellerMarlies BallegeerJulie DeckersCarlo RiccardiStefano BruscoliTino HochepiedClaude LibertPaloma Perez

A1 Journal Article in SCIENTIFIC REPORTS

p120 Catenin-mediated stabilization of E-cadherin is essential for primitive endoderm specification

Tim PietersSteven GoossensLieven HaenebalckeVanessa AndriesAgata StryjewskaRiet De RyckeKelly LemeireTino HochepiedDanny HuylebroeckGeert BerxMarc P StemmlerDagmar WirthJody HaighJolanda van HengelFrans Van Roy

A1 Journal Article in PLOS GENETICS

2015

An ER-directed gelsolin nanobody targets the first step in amyloid formation in a gelsolin amyloidosis mouse model

Wouter Van OverbekeJantana WongsantichonInge EveraertAdriaan VerhelleOlivier ZwaenepoelAnantasak LoonchantaLeslie D BurtnickAriane De GanckTino HochepiedJody HaighClaude CuvelierWim DeraveRobert C RobinsonJan Gettemans

A1 Journal Article in HUMAN MOLECULAR GENETICS

Cardiovascular and pharmacological implications of haem-deficient NO-unresponsive soluble guanylate cyclase knock-in mice

Robrecht ThoonenAnje CauwelsKelly DecaluwéSandra GeschkaRobert E TainshJoris DelangheTino HochepiedLode De CauwerElke RoggeSofie VoetPatrick SipsRichard H KarasKenneth D BlochMarnik VuylstekeJohannes-Peter StaschJohan Van de VoordeEmmanuel S BuysPeter Brouckaert

A1 Journal Article in NATURE COMMUNICATIONS

2014

Heme-deficient NO-unresponsive sGC knock-in mice: novel aspects of NO sGC signaling in cardiovascular (patho)physiology

Robrecht ThoonenEmmanuel BuysAnje CauwelsKelly DecaluwéSandra GeschkaRobert TainshJoris DelangheTino HochepiedLode De CauwerElke RoggePatrick SipsRichard KarasKenneth BlochJohan Van de VoordeJohannes-Peter StaschMarnik VuylstekePeter Brouckaert

2013

Mice overexpressing β-1,4-galactosyltransferase I are resistant to TNF-induced inflammation and DSS-induced colitis

Valerie VanhoorenRoosmarijn VandenbrouckeSylviane DewaeleEvelien Van HammeJody HaighTino HochepiedClaude Libert

A1 Journal Article in PLOS ONE

RNF4 is required for DNA double-strand break repair in vivo

R VyasR KumarF ClermontA HelfrichtP KalevP SotiropoulouIA HendriksE RadaelliTino HochepiedC BlanpainA SablinaH van AttikumJV OlsenAG JochemsenACO VertegaalJ-C Marine

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

The ROSA26-iPSC mouse : a conditional, inducible, and exchangeable resource for studying cellular (de)differentiation

Lieven HaenebalckeSteven GoossensPieterjan DierickxSona BartunkovaJinke D'HontKatharina HaighTino HochepiedDagmar WirthAndras NagyJody Haigh

A1 Journal Article in CELL REPORTS

2012

Efficient and user-friendly pluripotin-based derivation of mouse embryonic stem cells

Tim PietersLieven HaenebalckeTino HochepiedJinke D'HontJody HaighFrans Van RoyJolanda van Hengel

A1 Journal Article in STEM CELL REVIEWS AND REPORTS

2011

Cop1 constitutively regulates c-Jun protein stability and functions as a tumor suppressor in mice

Domenico MiglioriniSven BogaertsDieter DefeverRajesh VyasGeertrui DeneckerEnrico RadaelliAleksandra ZwolinskaVanessa DepaepeTino HochepiedWilliam C SkarnesJean-Christophe Marine

A1 Journal Article in JOURNAL OF CLINICAL INVESTIGATION

2007

Caspase-14 protects against epidermal UVB photo-damage and water loss

Geertrui DeneckerEsther HosteBarbara GilbertTino HochepiedPetra OvaereSaskia LippensC VAN DEN BROUCKEPetra Van DammeKatharina D'HerdeJ HACHEMGaetan BorgonieR PRESLANDL SCHOONJANSClaude LibertJoël VandekerckhoveKris GevaertPeter VandenabeeleWim Declercq

Caspase-14 protects against epidermal UVB photo-damage and water loss.

Geertrui DeneckerEsther HosteBarbara GilbertTino HochepiedPetra OvaereSaskia LippensC VAN DEN BROUCKEPetra Van DammeKatharina D'HerdeJ HACHEMGaetan BorgonieR PRESLANDL SCHOONJANSClaude LibertJoël VandekerckhoveKris GevaertPeter VandenabeeleWim Declercq

Caspase-14 protects against epidermal UVB photodamage and water loss

Geertrui DeneckerEsther HosteBarbara GilbertTino HochepiedPetra OvaereSaskia LippensCaroline Van den broeckePetra Van DammeKatharina D'HerdeJP HACHEMGaetan BorgonieRB PRESLANDL SCHOONJANSClaude LibertJoël VandekerckhoveKris GevaertPeter VandenabeeleWim Declercq

A1 Journal Article in NATURE CELL BIOLOGY

2006

Role of caspase-14 in terminal differentiation of keratinocytes

Geertrui DeneckerEsther HosteBarbara GilbertTino HochepiedPetra OvaereSaskia LippensCaroline VandenbrouckeKatharina D'HerdePeter VandenabeeleWim Declercq

The wild-derived inbred mouse strain SPRET/Ei is resistant to LPS and defective in IFN-beta production

Tina MahieuJM PARKH REVETSB PASCHEA LENGELINGJan StaelensAndy WullaertIneke VanlaereTino HochepiedFrans Van RoyM KARINClaude Libert

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

2004

Breaking the species barrier: derivation of germline-competent embryonic stem cells from Mus spretus x C57BL/6 hybrids

Tino HochepiedLuc SchoonjansJan StaelensVeerle KreemersSophie DanloyLeen PuimègeDésiré CollenFrans Van RoyClaude Libert

A1 Journal Article in STEM CELLS

Exogenous alpha-1-acid glycoprotein protects against renal ischemia-reperfusion injury by inhibition of inflammation and apoptosis

B DE VRIESSJ WALTERTGAM WOLFSTino HochepiedJ RABINAP HEERINGAJ PARKKINENClaude LibertWA BUURMAN

A1 Journal Article in TRANSPLANTATION

Response of TNF-hyporesponsive SPRET/Ei mice in models of inflammatory disorders

Jan StaelensLeen PuimègeTina MahieuGwenda PynaertTino HochepiedAnnelies VandenabeeleJohan GrootenDimitris KontoyiannisFrans Van RoyGeorge KolliasClaude Libert

A1 Journal Article in MAMMALIAN GENOME

2003

alpha(1)-Acid glycoprotein: an acute phase protein with inflammatory and immunomodulating properties

Tino HochepiedFG BERGERH BAUMANNClaude Libert

A1 Journal Article in CYTOKINE & GROWTH FACTOR REVIEWS

2002

Mice lacking a 2-macroglobulin show an increased host defense against Gram-negative bacterial sepsis, but are more susceptible to endotoxic shock.

Tino HochepiedF VAN LEUVENClaude Libert

A1 Journal Article in EUROPEAN CYTOKINE NETWORK

Overexpression of alpha(1)-acid glycoprotein in transgenic mice leads to sensitisation to acute colitis.

Tino HochepiedAndy WullaertFG BERGERH BAUMANNPeter BrouckaertLothar SteidlerClaude Libert

A1 Journal Article in GUT

2001

Detection, characterisation and purification of a murine liver factor capable of desensitising towards the lethal activity of tumour necrosis factor.

Ben WielockxTino HochepiedJan StaelensWim Van MollePeter BrouckaertClaude Libert

A1 Journal Article in CYTOKINE

2000

Differential response of alpha(2)-macroglobulin-deficient mice in models of lethal TNF-induced inflammation.

Tino HochepiedPaul AmelootPeter BrouckaertF VAN LEUVENClaude Libert

A1 Journal Article in EUROPEAN CYTOKINE NETWORK

Involvement of the acute phase protein alpha(1)-acid glycoprotein in nonspecific resistance to a lethal Gram-negative infection.

Tino HochepiedWim Van MolleFG BERGERH BAUMANNClaude Libert

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

The major acute-phase protein, serum amyloid P component, in mice is not involved in endogenous resistance against tumor necrosis factor alpha-induced lethal hepatitis, shock, and skin necrosis.

Wim Van MolleTino HochepiedPeter BrouckaertClaude Libert

A1 Journal Article in INFECTION AND IMMUNITY

1998

High-level constitutive expression of alpha(1)-acid glycoprotein and lack of protection against tumor necrosis factor-induced lethal shock in transgenic mice.

Claude LibertTino HochepiedFG BERGERH BAUMANNWalter FiersPeter Brouckaert

A1 Journal Article in TRANSGENIC RESEARCH