Research Explorer

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Researcher

Tino Hochepied

56 Results

2022

A20 controls RANK-dependent osteoclast formation and bone physiology

Arne MartensPieter HertensDario PriemLisette Van HoveEls LouagieJulie CoudenysAmélie De MuynckDjoere GaublommeMozes SzeJolanda van HengelLeen CatrysseEsther HosteLuc Van HoorebekeTino HochepiedMathieu BertrandDirk ElewautGeert van Loo

A1 Journal Article in EMBO REPORTS

Context-dependent effects of IL-2 rewire immunity into distinct cellular circuits

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

Innovative mouse models for the tumor suppressor activity of protocadherin-10 isoforms

Ellen SandersKatrien StaesMarleen Van TroysTino HochepiedKelly LemeireLiesbet MartensChristophe AmpeFrans Van Roy

A1 Journal Article in BMC CANCER

Myb drives B-cell neoplasms and myeloid malignancies in vivo

Tim PietersAndré Pedro Pinto De AlmeidaSara T'SasKelly LemeireTino HochepiedGeert BerxSteven GoossensPieter Van Vlierberghe

A1 Journal Article in BLOOD ADVANCES

Point mutation I634A in the glucocorticoid receptor causes embryonic lethality by reduced ligand binding

Steven TimmermansKelly Van LooverenSylviane DewaeleTino HochepiedMelanie EggermontBarbara GilbertTineke VanderhaeghenJoke Vanden BergheNatalia Garcia GonzalezJolien VandewalleYehudi BlochMathias ProvostSavvas SavvidesKarolien De BosscherWim DeclercqClaude Libert

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Single-cell genome sequencing of human neurons identifies somatic point mutation and indel enrichment in regulatory elements

Tino HochepiedClaude Libert

A1 Journal Article in NATURE GENETICS

2021

A new transgenic mouse line for imaging mitochondrial calcium signals

A2 Journal Article in FUNCTION

Cyclin D2 overexpression drives B1a-derived MCL-like lymphoma in mice

Tim PietersSara T'SasStijn VanheeAndré Pedro Pinto De AlmeidaYasmine DriegeJuliette RoelsWouter Van LoockeWillem DaneelsMaaike Van TrimpontFilip MatthijssensJulie MorscioKelly LemeireBéatrice LintermansLindy ReunesFritz OffnerJo Van DorpeTino HochepiedGeert BerxRudi BeyaertJens StaalPieter Van VlierbergheSteven Goossens

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

Fibrotic enzymes modulate wound-induced skin tumorigenesis

Lisette Van HoveKim LecomteJana RoelsNiels VandammeHanna-Kaisa VikkulaIsabelle HoorensKatia OngenaeTino HochepiedYvan SaeysGeert van LooEsther Hoste

A1 Journal Article in EMBO REPORTS

OTULIN maintains skin homeostasis by controlling keratinocyte death and stem cell identity

Esther HosteKim LecomteNiels VandammeJana RoelsSophia MaschalidiLien VerboomHanna-Kaisa VikkulaMozes SzeLisette Van HoveKevin VerstaenArne MartensTino HochepiedYvan SaeysKodi RavichandranGeert van Loo

A1 Journal Article in NATURE COMMUNICATIONS

Response to correspondence on 'Reproducibility of CRISPR-Cas9 methods for generation of conditional mouse alleles : a multi-center evaluation'

Jinke D'HontKatrien StaesLeen VanhoutteFrédérique VanrockeghemTino Hochepied

A1 Journal Article in GENOME BIOLOGY

Ring finger protein 213 assembles into a sensor for ISGylated proteins with antimicrobial activity

Fabien Henri TheryLia MartinaCaroline AsselmanHeidi RepoKoen SedeynGeorgios MoschonasDenzel EggermontDelphine De SutterKatie BoucherTino HochepiedNele FestjensNico CallewaertXavier SaelensBart DermautSven EyckermanFrancis Impens

A1 Journal Article in NATURE COMMUNICATIONS

2020

MALT1 targeting suppresses CARD14‐induced psoriatic dermatitis in mice

Elien Van NuffelJens StaalGriet BaudeletMira HaegmanYasmine DriegeTino HochepiedInna AfoninaRudi Beyaert

A1 Journal Article in EMBO REPORTS

Two distinct ubiquitin-binding motifs in A20 mediate its anti-inflammatory and cell-protective activities

Arne MartensDario PriemEsther HosteJessica VettersSofie RennenSofie VoetLaura DeelenMozes SzeHanna-Kaisa VikkulaKarolina SlowickaTino HochepiedAndy WullaertSophie JanssensMohamed LamkanfiRudi BeyaertMathieu BertrandGeert van Loo

A1 Journal Article in NATURE IMMUNOLOGY

Zinc inhibits lethal inflammatory shock by preventing microbe-induced interferon signature in intestinal epithelium

Jolien SouffriauSteven TimmermansTineke VanderhaeghenCharlotte WallaeysKelly Van LooverenLindsy AelbrechtSylviane DewaeleJolien VandewalleEvy GoossensSerge VerbanckFilip BoyenMelanie EggermontRiet De RyckeMichiel De BruyneMarlies BallegeerSofie VandevyverTino HochepiedKarolien De BosscherFilip Van ImmerseelRudi BeyaertClaude Libert

A1 Journal Article in EMBO MOLECULAR MEDICINE

2019

A new mouse model to study the role of ectopic Nanos3 expression in cancer

Vanessa AndriesEvi De KeuckelaereKatrien StaesTino HochepiedJoachim TaminauKelly LemeireGeert BerxFrans Van Roy

A1 Journal Article in BMC CANCER

MALT1 proteolytic activity suppresses autoimmunity in a T cell intrinsic manner

Annelies DemeyerIoannis SkordosYasmine DriegeMarja KreikeTino HochepiedJens StaalRudi Beyaert

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Novel strategy for rapid functional in vivo validation of oncogenic drivers in haematological malignancies

Tim PietersSara T'SasLisa DemoenAndré Pedro Pinto De AlmeidaLieven HaenebalckeFilip MatthijssensKelly LemeireJinke D'HontFrédérique VanrockeghemTino HochepiedBéatrice LintermansLindy ReunesTim LammensGeert BerxSteven GoossensPieter Van Vlierberghe

A1 Journal Article in SCIENTIFIC REPORTS

Reproducibility of CRISPR-Cas9 methods for generation of conditional mouse alleles : a multi-center evaluation

Jinke D'HontKatrien StaesLeen VanhoutteFrédérique VanrockeghemTino Hochepied

A1 Journal Article in GENOME BIOLOGY

2018

A knock-in/knock-out mouse model of HSPB8-associated distal hereditary motor neuropathy and myopathy reveals toxic gain-of-function of mutant Hspb8

Tino HochepiedSteven GoossensClaude Libert

A1 Journal Article in ACTA NEUROPATHOLOGICA

DMRT5 together with DMRT3 directly controls hippocampus development and neocortical area map formation

A1 Journal Article in CEREBRAL CORTEX

Genetic mapping of species differences via in vitro crosses in mouse embryonic stem cells

Tino HochepiedMarc Van MontaguClaude Libert

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

2017

Caspase-1 engagement and TLR-induced c-FLIP expression suppress ASC/caspase-8-dependent apoptosis by inflammasome sensors NLRP1b and NLRC4

Nina Van OpdenboschHanne Van GorpMaarten VerdoncktPedro Henrique Viana SaavedraNathalia Moraes de VasconcelosAmanda GonçalvesLieselotte Vande WalleDieter DemonMagdalena MatusiakFilip Van HauwermeirenJinke D'HontTino HochepiedMohamed Lamkanfi

A1 Journal Article in CELL REPORTS

Elevated ΔNp63α levels facilitate epidermal and biliary oncogenic transformation

Michael DevosBarbara GilbertGeertrui DeneckerKirsten LeursConor Mc GuireKelly LemeireTino HochepiedJo LambertLouis LibbrechtJody HaighGeert BerxSaskia LippensPeter VandenabeeleWim Declercq

A1 Journal Article in JOURNAL OF INVESTIGATIVE DERMATOLOGY

Structure-function studies in mouse embryonic stem cells using recombinase-mediated cassette exchange

Tim PietersLieven HaenebalckeKenneth BruneelNiels VandammeTino HochepiedJolanda van HengelGeert BerxFrans Van RoySteven Goossens

A1 Journal Article in JOVE-JOURNAL OF VISUALIZED EXPERIMENTS

2016

Characterization of new transgenic mouse models for two Charcot-Marie-tooth-causing HspB1 mutations using the Rosa26 locus

Tino HochepiedSteven GoossensSophie Janssens

A2 Journal Article in JOURNAL OF NEUROMUSCULAR DISEASES

Familial Mediterranean fever mutations lift the obligatory requirement for microtubules in Pyrin inflammasome activation

Hanne Van GorpPedro Henrique Viana SaavedraNathalia Moraes de VasconcelosNina Van OpdenboschLieselotte Vande WalleMagdalena MatusiakFilip Van HauwermeirenDieter DemonDelfien BogaertMelissa DullaersElfride De BaereTino HochepiedJo DehoorneKarim VermaelenFilomeen HaerynckMohamed Lamkanfi

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fast generation of conditional ROSA26-based mouse models that recapitulate genomic events in human T-ALL

Tim PietersSteven GoossensSara T'SasLieven HaenebalckeTino HochepiedBéatrice LintermansSofie PeirsFilip MatthijssensGeert BerxPieter Van Vlierberghe

NLRP2 controls age-associated maternal fertility

Anna KuchmiyJinke D'HontTino HochepiedMohamed Lamkanfi

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

NOD-like receptor Nlrp2 is dispensable for immune signaling, but critical for efficient early embryonic development in aged oocytes

Anna KuchmiyTino HochepiedMohamed Lamkanfi

Overexpression of glucocorticoid-induced leucine zipper (GILZ) increases susceptibility to imiquimod-induced psoriasis and involves cutaneous activation of TGF-β1

Marlies BallegeerJulie DeckersTino HochepiedClaude Libert

A1 Journal Article in SCIENTIFIC REPORTS

p120 Catenin-mediated stabilization of E-cadherin is essential for primitive endoderm specification

Tim PietersSteven GoossensLieven HaenebalckeVanessa AndriesRiet De RyckeKelly LemeireTino HochepiedGeert BerxJody HaighJolanda van HengelFrans Van Roy

A1 Journal Article in PLOS GENETICS

2015

An ER-directed gelsolin nanobody targets the first step in amyloid formation in a gelsolin amyloidosis mouse model

Wouter Van OverbekeInge EveraertAdriaan VerhelleOlivier ZwaenepoelAriane De GanckTino HochepiedJody HaighClaude CuvelierWim DeraveJan Gettemans

A1 Journal Article in HUMAN MOLECULAR GENETICS

Cardiovascular and pharmacological implications of haem-deficient NO-unresponsive soluble guanylate cyclase knock-in mice

Robrecht ThoonenAnje CauwelsKelly DecaluwéJoris DelangheTino HochepiedLode De CauwerElke RoggeSofie VoetPatrick SipsMarnik VuylstekeJohan Van de VoordePeter Brouckaert

A1 Journal Article in NATURE COMMUNICATIONS

2014

Heme-deficient NO-unresponsive sGC knock-in mice: novel aspects of NO sGC signaling in cardiovascular (patho)physiology

Robrecht ThoonenEmmanuel BuysAnje CauwelsKelly DecaluwéJoris DelangheTino HochepiedLode De CauwerElke RoggePatrick SipsJohan Van de VoordeMarnik VuylstekePeter Brouckaert

2013

Mice overexpressing β-1,4-galactosyltransferase I are resistant to TNF-induced inflammation and DSS-induced colitis

Valerie VanhoorenRoosmarijn VandenbrouckeSylviane DewaeleEvelien Van HammeJody HaighTino HochepiedClaude Libert

A1 Journal Article in PLOS ONE

RNF4 is required for DNA double-strand break repair in vivo

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

The ROSA26-iPSC mouse : a conditional, inducible, and exchangeable resource for studying cellular (de)differentiation

Lieven HaenebalckeSteven GoossensPieterjan DierickxSona BartunkovaJinke D'HontKatharina HaighTino HochepiedJody Haigh

A1 Journal Article in CELL REPORTS

2012

Efficient and user-friendly pluripotin-based derivation of mouse embryonic stem cells

Tim PietersLieven HaenebalckeTino HochepiedJinke D'HontJody HaighFrans Van RoyJolanda van Hengel

A1 Journal Article in STEM CELL REVIEWS AND REPORTS

2011

Cop1 constitutively regulates c-Jun protein stability and functions as a tumor suppressor in mice

Domenico MiglioriniSven BogaertsDieter DefeverGeertrui DeneckerAleksandra ZwolinskaVanessa DepaepeTino HochepiedJean-Christophe Marine

A1 Journal Article in JOURNAL OF CLINICAL INVESTIGATION

2007

Caspase-14 protects against epidermal UVB photo-damage and water loss

Esther HosteBarbara GilbertTino HochepiedPetra OvaereSaskia LippensPetra Van DammeKatharina D'HerdeGaetan BorgonieClaude LibertJoël VandekerckhoveKris GevaertPeter VandenabeeleWim Declercq

Caspase-14 protects against epidermal UVB photo-damage and water loss.

Geertrui DeneckerEsther HosteBarbara GilbertTino HochepiedPetra OvaereSaskia LippensPetra Van DammeKatharina D'HerdeGaetan BorgonieClaude LibertJoël VandekerckhoveKris GevaertPeter VandenabeeleWim Declercq

Caspase-14 protects against epidermal UVB photodamage and water loss

Geertrui DeneckerEsther HosteBarbara GilbertTino HochepiedPetra OvaereSaskia LippensPetra Van DammeKatharina D'HerdeGaetan BorgonieClaude LibertJoël VandekerckhoveKris GevaertPeter VandenabeeleWim Declercq

A1 Journal Article in NATURE CELL BIOLOGY

2006

Role of caspase-14 in terminal differentiation of keratinocytes

Geertrui DeneckerEsther HosteBarbara GilbertTino HochepiedPetra OvaereSaskia LippensKatharina D'HerdePeter VandenabeeleWim Declercq

The wild-derived inbred mouse strain SPRET/Ei is resistant to LPS and defective in IFN-beta production

Tina MahieuJan StaelensAndy WullaertIneke VanlaereTino HochepiedFrans Van RoyClaude Libert

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

2004

Breaking the species barrier: derivation of germline-competent embryonic stem cells from Mus spretus x C57BL/6 hybrids

Tino HochepiedJan StaelensLeen PuimègeFrans Van RoyClaude Libert

A1 Journal Article in STEM CELLS

Exogenous alpha-1-acid glycoprotein protects against renal ischemia-reperfusion injury by inhibition of inflammation and apoptosis

Tino HochepiedClaude Libert

A1 Journal Article in TRANSPLANTATION

Response of TNF-hyporesponsive SPRET/Ei mice in models of inflammatory disorders

Jan StaelensLeen PuimègeTina MahieuTino HochepiedAnnelies VandenabeeleJohan GrootenFrans Van RoyClaude Libert

A1 Journal Article in MAMMALIAN GENOME

2003

alpha(1)-Acid glycoprotein: an acute phase protein with inflammatory and immunomodulating properties

Tino HochepiedClaude Libert

A1 Journal Article in CYTOKINE & GROWTH FACTOR REVIEWS

2002

Mice lacking a 2-macroglobulin show an increased host defense against Gram-negative bacterial sepsis, but are more susceptible to endotoxic shock.

Tino HochepiedClaude Libert

A1 Journal Article in EUROPEAN CYTOKINE NETWORK

Overexpression of alpha(1)-acid glycoprotein in transgenic mice leads to sensitisation to acute colitis.

Tino HochepiedAndy WullaertPeter BrouckaertLothar SteidlerClaude Libert

A1 Journal Article in GUT

2001

Detection, characterisation and purification of a murine liver factor capable of desensitising towards the lethal activity of tumour necrosis factor.

Ben WielockxTino HochepiedJan StaelensWim Van MollePeter BrouckaertClaude Libert

A1 Journal Article in CYTOKINE

2000

Differential response of alpha(2)-macroglobulin-deficient mice in models of lethal TNF-induced inflammation.

Tino HochepiedPaul AmelootPeter BrouckaertClaude Libert

A1 Journal Article in EUROPEAN CYTOKINE NETWORK

Involvement of the acute phase protein alpha(1)-acid glycoprotein in nonspecific resistance to a lethal Gram-negative infection.

Tino HochepiedWim Van MolleClaude Libert

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

The major acute-phase protein, serum amyloid P component, in mice is not involved in endogenous resistance against tumor necrosis factor alpha-induced lethal hepatitis, shock, and skin necrosis.

Wim Van MolleTino HochepiedPeter BrouckaertClaude Libert

A1 Journal Article in INFECTION AND IMMUNITY

1998

High-level constitutive expression of alpha(1)-acid glycoprotein and lack of protection against tumor necrosis factor-induced lethal shock in transgenic mice.

Claude LibertTino HochepiedWalther FiersPeter Brouckaert

A1 Journal Article in TRANSGENIC RESEARCH