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Researcher
Tino Hochepied
Profile
Projects
Publications
Activities
Awards & Distinctions
61
Results
2024
MeCP2 binds to methylated DNA independently of phase separation and heterochromatin organisation
Raphael Pantier
Megan Brown
Sicheng Han
Katie Paton
Stephen Meek
Thomas Montavon
Nicholas Shukeir
Toni Mchugh
David A. Kelly
Tino Hochepied
et al.
A1
Journal Article
in
NATURE COMMUNICATIONS
2024
2023
OTULIN protects the intestinal epithelium from apoptosis during inflammation and infection
Lien Verboom
Christopher Anderson
Maude Jans
Ioanna Petta
Gillian Blancke
Arne Martens
Mozes Sze
Tino Hochepied
Kodi Ravichandran
Lars Vereecke
et al.
A1
Journal Article
in
CELL DEATH & DISEASE
2023
Protein citrullination and NET formation do not contribute to the pathology of A20/TNFAIP3 mutant mice
Karel Van Damme
Pieter Hertens
Arne Martens
Elisabeth Gilis
Dario Priem
Inge Bruggeman
Amelie Fossoul
Jozefien Declercq
Helena Catharine Aegerter
Andy Wullaert
et al.
A1
Journal Article
in
SCIENTIFIC REPORTS
2023
Sterile triggers drive joint inflammation in TNF‐ and IL-1β‐dependent mouse arthritis models
Alexandra Thiran
Ioanna Petta
Gillian Blancke
Marie Thorp
Guillaume Planckaert
Maude Jans
Vanessa Andries
Korneel Barbry
Elisabeth Gilis
Julie Coudenys
et al.
A1
Journal Article
in
EMBO MOLECULAR MEDICINE
2023
The impact of hepatocyte-specific deletion of hypoxia-inducible factors on the development of polymicrobial sepsis with focus on GR and PPARα function
Tineke Vanderhaeghen
Steven Timmermans
Melanie Eggermont
Deepika Watts
Jolien Vandewalle
Charlotte Wallaeys
Louise Nuyttens
Joyca De Temmerman
Tino Hochepied
Sylviane Dewaele
et al.
A1
Journal Article
in
FRONTIERS IN IMMUNOLOGY
2023
2022
A20 controls RANK-dependent osteoclast formation and bone physiology
Arne Martens
Pieter Hertens
Dario Priem
Vagelis Rinotas
Theodore Meletakos
Meropi Gennadi
Lisette Van Hove
Els Louagie
Julie Coudenys
Amélie De Muynck
et al.
A1
Journal Article
in
EMBO REPORTS
2022
Context-dependent effects of IL-2 rewire immunity into distinct cellular circuits
Carly E. Whyte
Kailash Singh
Oliver T. Burton
Meryem Aloulou
Lubna Kouser
Rafael Valente Veiga
Amy Dashwood
Hanneke Okkenhaug
Samira Benadda
Alena Moudra
et al.
A1
Journal Article
in
JOURNAL OF EXPERIMENTAL MEDICINE
2022
Innovative mouse models for the tumor suppressor activity of protocadherin-10 isoforms
Irene Kleinberger
Ellen Sanders
Katrien Staes
Marleen Van Troys
Shinji Hirano
Tino Hochepied
Kelly Lemeire
Liesbet Martens
Christophe Ampe
Frans Van Roy
A1
Journal Article
in
BMC CANCER
2022
Myb drives B-cell neoplasms and myeloid malignancies in vivo
Tim Pieters
André Pedro Pinto De Almeida
Sara T'Sas
Kelly Lemeire
Tino Hochepied
Geert Berx
Alex Kentsis
Steven Goossens
Pieter Van Vlierberghe
A1
Journal Article
in
BLOOD ADVANCES
2022
Point mutation I634A in the glucocorticoid receptor causes embryonic lethality by reduced ligand binding
Steven Timmermans
Nicolette J.D. Verhoog
Kelly Van Looveren
Sylviane Dewaele
Tino Hochepied
Melanie Eggermont
Barbara Gilbert
Anne Boerema-de Munck
Tineke Vanderhaeghen
Joke Vanden Berghe
et al.
A1
Journal Article
in
JOURNAL OF BIOLOGICAL CHEMISTRY
2022
Single-cell genome sequencing of human neurons identifies somatic point mutation and indel enrichment in regulatory elements
Lovelace J. Luquette
Michael B. Miller
Zinan Zhou
Craig L. Bohrson
Yifan Zhao
Hu Jin
Doga Gulhan
Javier Ganz
Sara Bizzotto
Samantha Kirkham
et al.
A1
Journal Article
in
NATURE GENETICS
2022
2021
A new transgenic mouse line for imaging mitochondrial calcium signals
Nelly Redolfi
Elisa Greotti
Giulia Zanetti
Tino Hochepied
Cristina Fasolato
Diana Pendin
Tullio Pozzan
A2
Journal Article
in
FUNCTION
2021
Cyclin D2 overexpression drives B1a-derived MCL-like lymphoma in mice
Tim Pieters
Sara T'Sas
Stijn Vanhee
André Pedro Pinto De Almeida
Yasmine Driege
Juliette Roels
Wouter Van Loocke
Willem Daneels
Mathijs Baens
Arnaud Marchand
et al.
A1
Journal Article
in
JOURNAL OF EXPERIMENTAL MEDICINE
2021
Fibrotic enzymes modulate wound-induced skin tumorigenesis
Lisette Van Hove
Kim Lecomte
Jana Roels
Niels Vandamme
Hanna-Kaisa Vikkula
Isabelle Hoorens
Katia Ongenae
Tino Hochepied
Giacomo Donati
Yvan Saeys
et al.
A1
Journal Article
in
EMBO REPORTS
2021
OTULIN maintains skin homeostasis by controlling keratinocyte death and stem cell identity
Esther Hoste
Kim Lecomte
Karl Annusver
Niels Vandamme
Jana Roels
Sophia Maschalidi
Lien Verboom
Hanna-Kaisa Vikkula
Mozes Sze
Lisette Van Hove
et al.
A1
Journal Article
in
NATURE COMMUNICATIONS
2021
Response to correspondence on 'Reproducibility of CRISPR-Cas9 methods for generation of conditional mouse alleles : a multi-center evaluation'
Channabasavaiah B. Gurumurthy
Aidan R. O'Brien
Rolen M. Quadros
Jr. Adams, John
Pilar Alcaide
Shinya Ayabe
Johnathan Ballard
Surinder K. Batra
Marie-Claude Beauchamp
Kathleen A. Becker
et al.
A1
Journal Article
in
GENOME BIOLOGY
2021
Ring finger protein 213 assembles into a sensor for ISGylated proteins with antimicrobial activity
Fabien Henri Thery
Lia Martina
Caroline Asselman
Heidi Repo
Y Zhang
Koen Sedeyn
Georgios Moschonas
C Bredow
QW Teo
J Zhang
et al.
A1
Journal Article
in
NATURE COMMUNICATIONS
2021
2020
MALT1 targeting suppresses CARD14‐induced psoriatic dermatitis in mice
Elien Van Nuffel
Jens Staal
Griet Baudelet
Mira Haegman
Yasmine Driege
Tino Hochepied
Inna Afonina
Rudi Beyaert
A1
Journal Article
in
EMBO REPORTS
2020
Two distinct ubiquitin-binding motifs in A20 mediate its anti-inflammatory and cell-protective activities
Arne Martens
Dario Priem
Esther Hoste
Jessica Vetters
Sofie Rennen
Leen Catrysse
Sofie Voet
Laura Deelen
Mozes Sze
Hanna-Kaisa Vikkula
et al.
A1
Journal Article
in
NATURE IMMUNOLOGY
2020
Zinc inhibits lethal inflammatory shock by preventing microbe-induced interferon signature in intestinal epithelium
Jolien Souffriau
Steven Timmermans
Tineke Vanderhaeghen
Charlotte Wallaeys
Kelly Van Looveren
Lindsy Aelbrecht
Sylviane Dewaele
Jolien Vandewalle
Evy Goossens
Serge Verbanck
et al.
A1
Journal Article
in
EMBO MOLECULAR MEDICINE
2020
2019
A new mouse model to study the role of ectopic Nanos3 expression in cancer
Vanessa Andries
Evi De Keuckelaere
Katrien Staes
Tino Hochepied
Joachim Taminau
Kelly Lemeire
Philippe Birembaut
Geert Berx
Frans Van Roy
A1
Journal Article
in
BMC CANCER
2019
MALT1 proteolytic activity suppresses autoimmunity in a T cell intrinsic manner
Annelies Demeyer
Ioannis Skordos
Yasmine Driege
Marja Kreike
Tino Hochepied
Mathijs Baens
Jens Staal
Rudi Beyaert
A1
Journal Article
in
FRONTIERS IN IMMUNOLOGY
2019
Novel strategy for rapid functional in vivo validation of oncogenic drivers in haematological malignancies
Tim Pieters
Sara T'Sas
Lisa Demoen
André Pedro Pinto De Almeida
Lieven Haenebalcke
Filip Matthijssens
Kelly Lemeire
Jinke D'Hont
Frédérique Vanrockeghem
Tino Hochepied
et al.
A1
Journal Article
in
SCIENTIFIC REPORTS
2019
Reproducibility of CRISPR-Cas9 methods for generation of conditional mouse alleles : a multi-center evaluation
Channabasavaiah B. Gurumurthy
Aidan R O'Brien
Rolen M Quadros
John Adams
Pilar Alcaide
Shinya Ayabe
Johnathan Ballard
Surinder K Batra
Marie-Claude Beauchamp
Kathleen A Becker
et al.
A1
Journal Article
in
GENOME BIOLOGY
2019
2018
A knock-in/knock-out mouse model of HSPB8-associated distal hereditary motor neuropathy and myopathy reveals toxic gain-of-function of mutant Hspb8
Delphine Bouhy
Manisha Juneja
Istvan Katona
Anne Holmgren
Bob Asselbergh
Vicky De Winter
Tino Hochepied
Steven Goossens
Jody J Haigh
Claude Libert
et al.
A1
Journal Article
in
ACTA NEUROPATHOLOGICA
2018
DMRT5 together with DMRT3 directly controls hippocampus development and neocortical area map formation
Sarah De Clercq
Marc Keruzore
Elodie Desmaris
Charlotte Pollart
Stavroula Assimacopoulos
Julie Preillon
Sabrina Ascenzo
Clinton K Matson
Melody Lee
Xinsheng Nan
et al.
A1
Journal Article
in
CEREBRAL CORTEX
2018
Genetic mapping of species differences via in vitro crosses in mouse embryonic stem cells
Stefano Lazzarano
Marek Kucka
Joao PL Castro
Ronald Naumann
Paloma Medina
Michael NC Fletcher
Rebecka Wombacher
Joost Gribnau
Tino Hochepied
Marc Van Montagu
et al.
A1
Journal Article
in
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
2018
2017
Caspase-1 engagement and TLR-induced c-FLIP expression suppress ASC/caspase-8-dependent apoptosis by inflammasome sensors NLRP1b and NLRC4
Nina Van Opdenbosch
Hanne Van Gorp
Maarten Verdonckt
Pedro Henrique Viana Saavedra
Nathalia Moraes de Vasconcelos
Amanda Gonçalves
Lieselotte Vande Walle
Dieter Demon
Magdalena Matusiak
Filip Van Hauwermeiren
et al.
A1
Journal Article
in
CELL REPORTS
2017
Elevated ΔNp63α levels facilitate epidermal and biliary oncogenic transformation
Michael Devos
Barbara Gilbert
Geertrui Denecker
Kirsten Leurs
Conor Mc Guire
Kelly Lemeire
Tino Hochepied
Marnik Vuylsteke
Jo Lambert
Caroline Van den Broecke
et al.
A1
Journal Article
in
JOURNAL OF INVESTIGATIVE DERMATOLOGY
2017
Structure-function studies in mouse embryonic stem cells using recombinase-mediated cassette exchange
Tim Pieters
Lieven Haenebalcke
Kenneth Bruneel
Niels Vandamme
Tino Hochepied
Jolanda van Hengel
Dagmar Wirth
Geert Berx
Jody J Haigh
Frans Van Roy
et al.
A1
Journal Article
in
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
2017
2016
Characterization of new transgenic mouse models for two Charcot-Marie-tooth-causing HspB1 mutations using the Rosa26 locus
Delphine Bouhy
Thomas Geuens
Vicky De Winter
Leonardo De Almeida Souza
Istvan Katona
Joachim Weis
Tino Hochepied
Steven Goossens
Jody Haigh
Sophie Janssens
et al.
A2
Journal Article
in
JOURNAL OF NEUROMUSCULAR DISEASES
2016
Familial Mediterranean fever mutations lift the obligatory requirement for microtubules in Pyrin inflammasome activation
Hanne Van Gorp
Pedro Henrique Viana Saavedra
Nathalia Moraes de Vasconcelos
Nina Van Opdenbosch
Lieselotte Vande Walle
Magdalena Matusiak
Giusi Prencipe
Antonella Insalaco
Filip Van Hauwermeiren
Dieter Demon
et al.
A1
Journal Article
in
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
2016
Fast generation of conditional ROSA26-based mouse models that recapitulate genomic events in human T-ALL
Tim Pieters
Steven Goossens
Sara T'Sas
Lieven Haenebalcke
Tino Hochepied
Béatrice Lintermans
Sofie Peirs
Filip Matthijssens
J Haigh
Geert Berx
et al.
C3
Conference
2016
NLRP2 controls age-associated maternal fertility
Anna Kuchmiy
Jinke D'Hont
Tino Hochepied
Mohamed Lamkanfi
A1
Journal Article
in
JOURNAL OF EXPERIMENTAL MEDICINE
2016
NOD-like receptor Nlrp2 is dispensable for immune signaling, but critical for efficient early embryonic development in aged oocytes
Anna Kuchmiy
Jinke D’Hont
Tino Hochepied
Mohamed Lamkanfi
C3
Conference
2016
Overexpression of glucocorticoid-induced leucine zipper (GILZ) increases susceptibility to imiquimod-induced psoriasis and involves cutaneous activation of TGF-β1
Elena Carceller
Marlies Ballegeer
Julie Deckers
Carlo Riccardi
Stefano Bruscoli
Tino Hochepied
Claude Libert
Paloma Perez
A1
Journal Article
in
SCIENTIFIC REPORTS
2016
p120 Catenin-mediated stabilization of E-cadherin is essential for primitive endoderm specification
Tim Pieters
Steven Goossens
Lieven Haenebalcke
Vanessa Andries
Agata Stryjewska
Riet De Rycke
Kelly Lemeire
Tino Hochepied
Danny Huylebroeck
Geert Berx
et al.
A1
Journal Article
in
PLOS GENETICS
2016
2015
An ER-directed gelsolin nanobody targets the first step in amyloid formation in a gelsolin amyloidosis mouse model
Wouter Van Overbeke
Jantana Wongsantichon
Inge Everaert
Adriaan Verhelle
Olivier Zwaenepoel
Anantasak Loonchanta
Leslie D Burtnick
Ariane De Ganck
Tino Hochepied
Jody Haigh
et al.
A1
Journal Article
in
HUMAN MOLECULAR GENETICS
2015
Cardiovascular and pharmacological implications of haem-deficient NO-unresponsive soluble guanylate cyclase knock-in mice
Robrecht Thoonen
Anje Cauwels
Kelly Decaluwé
Sandra Geschka
Robert E Tainsh
Joris Delanghe
Tino Hochepied
Lode De Cauwer
Elke Rogge
Sofie Voet
et al.
A1
Journal Article
in
NATURE COMMUNICATIONS
2015
2014
Heme-deficient NO-unresponsive sGC knock-in mice: novel aspects of NO sGC signaling in cardiovascular (patho)physiology
Robrecht Thoonen
Emmanuel Buys
Anje Cauwels
Kelly Decaluwé
Sandra Geschka
Robert Tainsh
Joris Delanghe
Tino Hochepied
Lode De Cauwer
Elke Rogge
et al.
C3
Conference
2014
2013
Mice overexpressing β-1,4-galactosyltransferase I are resistant to TNF-induced inflammation and DSS-induced colitis
Valerie Vanhooren
Roosmarijn Vandenbroucke
Sylviane Dewaele
Evelien Van Hamme
Jody Haigh
Tino Hochepied
Claude Libert
A1
Journal Article
in
PLOS ONE
2013
RNF4 is required for DNA double-strand break repair in vivo
R Vyas
R Kumar
F Clermont
A Helfricht
P Kalev
P Sotiropoulou
IA Hendriks
E Radaelli
Tino Hochepied
C Blanpain
et al.
A1
Journal Article
in
CELL DEATH AND DIFFERENTIATION
2013
The ROSA26-iPSC mouse : a conditional, inducible, and exchangeable resource for studying cellular (de)differentiation
Lieven Haenebalcke
Steven Goossens
Pieterjan Dierickx
Sona Bartunkova
Jinke D'Hont
Katharina Haigh
Tino Hochepied
Dagmar Wirth
Andras Nagy
Jody Haigh
A1
Journal Article
in
CELL REPORTS
2013
2012
Efficient and user-friendly pluripotin-based derivation of mouse embryonic stem cells
Tim Pieters
Lieven Haenebalcke
Tino Hochepied
Jinke D'Hont
Jody Haigh
Frans Van Roy
Jolanda van Hengel
A1
Journal Article
in
STEM CELL REVIEWS AND REPORTS
2012
2011
Cop1 constitutively regulates c-Jun protein stability and functions as a tumor suppressor in mice
Domenico Migliorini
Sven Bogaerts
Dieter Defever
Rajesh Vyas
Geertrui Denecker
Enrico Radaelli
Aleksandra Zwolinska
Vanessa Depaepe
Tino Hochepied
William C Skarnes
et al.
A1
Journal Article
in
JOURNAL OF CLINICAL INVESTIGATION
2011
2007
Caspase-14 protects against epidermal UVB photo-damage and water loss
Geertrui Denecker
Esther Hoste
Barbara Gilbert
Tino Hochepied
Petra Ovaere
Saskia Lippens
C VAN DEN BROUCKE
Petra Van Damme
Katharina D'Herde
J HACHEM
et al.
C3
Conference
2007
Caspase-14 protects against epidermal UVB photo-damage and water loss.
Geertrui Denecker
Esther Hoste
Barbara Gilbert
Tino Hochepied
Petra Ovaere
Saskia Lippens
C VAN DEN BROUCKE
Petra Van Damme
Katharina D'Herde
J HACHEM
et al.
C3
Conference
2007
Caspase-14 protects against epidermal UVB photodamage and water loss
Geertrui Denecker
Esther Hoste
Barbara Gilbert
Tino Hochepied
Petra Ovaere
Saskia Lippens
Caroline Van den broecke
Petra Van Damme
Katharina D'Herde
JP HACHEM
et al.
A1
Journal Article
in
NATURE CELL BIOLOGY
2007
2006
Role of caspase-14 in terminal differentiation of keratinocytes
Geertrui Denecker
Esther Hoste
Barbara Gilbert
Tino Hochepied
Petra Ovaere
Saskia Lippens
Caroline Vandenbroucke
Katharina D'Herde
Peter Vandenabeele
Wim Declercq
C3
Conference
2006
The wild-derived inbred mouse strain SPRET/Ei is resistant to LPS and defective in IFN-beta production
Tina Mahieu
JM PARK
H REVETS
B PASCHE
A LENGELING
Jan Staelens
Andy Wullaert
Ineke Vanlaere
Tino Hochepied
Frans Van Roy
et al.
A1
Journal Article
in
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
2006
2004
Breaking the species barrier: derivation of germline-competent embryonic stem cells from Mus spretus x C57BL/6 hybrids
Tino Hochepied
Luc Schoonjans
Jan Staelens
Veerle Kreemers
Sophie Danloy
Leen Puimège
Désiré Collen
Frans Van Roy
Claude Libert
A1
Journal Article
in
STEM CELLS
2004
Exogenous alpha-1-acid glycoprotein protects against renal ischemia-reperfusion injury by inhibition of inflammation and apoptosis
B DE VRIES
SJ WALTER
TGAM WOLFS
Tino Hochepied
J RABINA
P HEERINGA
J PARKKINEN
Claude Libert
WA BUURMAN
A1
Journal Article
in
TRANSPLANTATION
2004
Response of TNF-hyporesponsive SPRET/Ei mice in models of inflammatory disorders
Jan Staelens
Leen Puimège
Tina Mahieu
Gwenda Pynaert
Tino Hochepied
Annelies Vandenabeele
Johan Grooten
Dimitris Kontoyiannis
Frans Van Roy
George Kollias
et al.
A1
Journal Article
in
MAMMALIAN GENOME
2004
2003
alpha(1)-Acid glycoprotein: an acute phase protein with inflammatory and immunomodulating properties
Tino Hochepied
FG BERGER
H BAUMANN
Claude Libert
A1
Journal Article
in
CYTOKINE & GROWTH FACTOR REVIEWS
2003
2002
Mice lacking a 2-macroglobulin show an increased host defense against Gram-negative bacterial sepsis, but are more susceptible to endotoxic shock.
Tino Hochepied
F VAN LEUVEN
Claude Libert
A1
Journal Article
in
EUROPEAN CYTOKINE NETWORK
2002
Overexpression of alpha(1)-acid glycoprotein in transgenic mice leads to sensitisation to acute colitis.
Tino Hochepied
Andy Wullaert
FG BERGER
H BAUMANN
Peter Brouckaert
Lothar Steidler
Claude Libert
A1
Journal Article
in
GUT
2002
2001
Detection, characterisation and purification of a murine liver factor capable of desensitising towards the lethal activity of tumour necrosis factor.
Ben Wielockx
Tino Hochepied
Jan Staelens
Wim Van Molle
Peter Brouckaert
Claude Libert
A1
Journal Article
in
CYTOKINE
2001
2000
Differential response of alpha(2)-macroglobulin-deficient mice in models of lethal TNF-induced inflammation.
Tino Hochepied
Paul Ameloot
Peter Brouckaert
F VAN LEUVEN
Claude Libert
A1
Journal Article
in
EUROPEAN CYTOKINE NETWORK
2000
Involvement of the acute phase protein alpha(1)-acid glycoprotein in nonspecific resistance to a lethal Gram-negative infection.
Tino Hochepied
Wim Van Molle
FG BERGER
H BAUMANN
Claude Libert
A1
Journal Article
in
JOURNAL OF BIOLOGICAL CHEMISTRY
2000
The major acute-phase protein, serum amyloid P component, in mice is not involved in endogenous resistance against tumor necrosis factor alpha-induced lethal hepatitis, shock, and skin necrosis.
Wim Van Molle
Tino Hochepied
Peter Brouckaert
Claude Libert
A1
Journal Article
in
INFECTION AND IMMUNITY
2000
1998
High-level constitutive expression of alpha(1)-acid glycoprotein and lack of protection against tumor necrosis factor-induced lethal shock in transgenic mice.
Claude Libert
Tino Hochepied
FG BERGER
H BAUMANN
Walther Fiers
Peter Brouckaert
A1
Journal Article
in
TRANSGENIC RESEARCH
1998