Research Explorer

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Researcher

Tineke Vanderhaeghen

14 Results

2022

Point mutation I634A in the glucocorticoid receptor causes embryonic lethality by reduced ligand binding

Steven TimmermansKelly Van LooverenSylviane DewaeleTino HochepiedMelanie EggermontBarbara GilbertTineke VanderhaeghenJoke Vanden BergheNatalia Garcia GonzalezJolien VandewalleYehudi BlochMathias ProvostSavvas SavvidesKarolien De BosscherWim DeclercqClaude Libert

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Reprogramming of glucocorticoid receptor function by hypoxia

Tineke VanderhaeghenSteven TimmermansMelanie EggermontJolien VandewalleCharlotte WallaeysLise Van WyngeneKelly Van LooverenLouise NuyttensSylviane DewaeleJoke Vanden BergheKelly LemeireKarolien De BosscherRudi BeyaertClaude Libert

A1 Journal Article in EMBO REPORTS

2021

Bidirectional crosstalk between hypoxia inducible factors and glucocorticoid signalling in health and disease

Tineke VanderhaeghenRudi BeyaertClaude Libert

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Combined glucocorticoid resistance and hyperlactatemia contributes to lethal shock in sepsis

Jolien VandewalleSteven TimmermansLies VancraeynestTineke VanderhaeghenCharlotte WallaeysLise Van WyngeneKelly Van LooverenLouise NuyttensMelanie EggermontSylviane DewaeleKarolien De BosscherJohan Van de VoordeClaude Libert

A1 Journal Article in CELL METABOLISM

The effect of hypoxia and hypoxia inducible factors on the glucocorticoid receptor function and their role during sepsis

Tineke VanderhaeghenClaude LibertRudi Beyaert

Turning a pathogen protein into a therapeutic tool for sepsis

Tineke VanderhaeghenCharlotte WallaeysClaude Libert

Editorial material

ZBTB32 performs crosstalk with the glucocorticoid receptor and is crucial in glucocorticoid responses to starvation

Lise Van WyngeneTineke VanderhaeghenIoanna PettaSteven TimmermansJolien VandewalleKelly Van LooverenCharlotte WallaeysMelanie EggermontSylviane DewaeleGeert van LooRudi BeyaertJan TavernierKarolien De BosscherClaude Libert

A1 Journal Article in ISCIENCE

2020

Glucocorticoids limit lipopolysaccharide-induced lethal inflammation by a double control system

Kelly Van LooverenSteven TimmermansTineke VanderhaeghenCharlotte WallaeysMarlies BallegeerJolien SouffriauMelanie EggermontJolien VandewalleLise Van WyngeneKarolien De BosscherClaude Libert

A1 Journal Article in EMBO REPORTS

Hepatic PPARα function and lipid metabolic pathways are dysregulated in polymicrobial sepsis

Lise Van WyngeneTineke VanderhaeghenSteven TimmermansJolien VandewalleKelly Van LooverenJolien SouffriauCharlotte WallaeysMelanie EggermontSam ErnstEvelien Van HammeAmanda GonçalvesAnneleen RemmerieCharlotte ScottCaroline RomboutsLynn VanhaeckeLiesbet De BusJohan DecruyenaereClaude Libert

A1 Journal Article in EMBO MOLECULAR MEDICINE

Hypoxia-inducible factors in metabolic reprogramming during sepsis

Tineke VanderhaeghenJolien VandewalleClaude Libert

A1 Journal Article in FEBS JOURNAL

Taking the STING out of sepsis?

Jolien VandewalleTineke VanderhaeghenRudi BeyaertClaude Libert

Editorial material

Zinc inhibits lethal inflammatory shock by preventing microbe-induced interferon signature in intestinal epithelium

Jolien SouffriauSteven TimmermansTineke VanderhaeghenCharlotte WallaeysKelly Van LooverenLindsy AelbrechtSylviane DewaeleJolien VandewalleEvy GoossensSerge VerbanckFilip BoyenMelanie EggermontRiet De RyckeMichiel De BruyneMarlies BallegeerSofie VandevyverTino HochepiedKarolien De BosscherFilip Van ImmerseelRudi BeyaertClaude Libert

A1 Journal Article in EMBO MOLECULAR MEDICINE

2019

TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile

Karen DendonckerSteven TimmermansJolien VandewalleMelanie EggermontEvelien Van HammeSylviane DewaeleSofie VandevyverMarlies BallegeerJolien SouffriauLise Van WyngeneKelly Van LooverenTineke VanderhaeghenRudi BeyaertKarolien De BosscherMarc Van MontaguClaude Libert

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

2018

Using the inbred mouse strain SPRET/EiJ to provide novel insights in inflammation and infection research

Steven TimmermansJolien SouffriauJolien VandewalleLise Van WyngeneKelly Van LooverenTineke VanderhaeghenClaude Libert

A1 Journal Article in MAMMALIAN GENOME