Research Explorer

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Researcher

Tineke Vanderhaeghen

Publications & Research Data

Awards & Distinctions

27 Results

2025

Cytochrome P450 activity in sepsis : insights into gene expression and enzymatic dysfunction

Fëllanza HalimiJolien VandewalleTineke VanderhaeghenCharlotte CuypersBruna AlonsoBruno GarciaAntoine HerpainSteven TimmermansClaude LibertStijn Schauvliege et al.

Cytochrome P450 activity in sepsis : insights into multilevel disruption of hepatic drug metabolism

Fëllanza HalimiJolien VandewalleTineke VanderhaeghenCharlotte CuypersBruna AlonsoBruno GarciaAntoine HerpainSteven TimmermansClaude LibertStijn Schauvliege et al.

Modulation of glucocorticoid receptor function under iron overload

Wanting ZhuTineke VanderhaeghenSteven TimmermansJolien VandewalleMelanie EggermontNicolette J. D. VerhoogClaude Libert

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

2024

A critical role for HNF4α in polymicrobial sepsis-associated metabolic reprogramming and death

Céline Van DenderSteven TimmermansVille PaakinahoTineke VanderhaeghenJolien VandewalleMaarten ClaesBruno GarciaBart RomanJan De WaeleSiska Croubels et al.

A1 Journal Article in EMBO MOLECULAR MEDICINE

Comparative analysis of hepatic gene expression profiles in murine and porcine sepsis models

Fëllanza HalimiTineke VanderhaeghenSteven TimmermansSiska CroubelsClaude LibertJolien Vandewalle

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Crosstalk interactions between transcription factors ERRα and PPARα assist PPARα-mediated gene expression

Sofie DesmetJonathan ThommisTineke VanderhaeghenEdmee VandenboornDorien ClarisseYunkun LiSteven TimmermansDaria FijalkowskaDariusz RatmanEvelien Van Hamme et al.

A1 Journal Article in MOLECULAR METABOLISM

Loss of PPARα function promotes epigenetic dysregulation of lipid homeostasis driving ferroptosis and pyroptosis lipotoxicity in metabolic dysfunction associated Steatotic liver disease (MASLD)

Claudia TheysTineke VanderhaeghenEvelien Van DijckCedric PelemanAnne ScheepersJoe IbrahimLigia MateiuSteven TimmermansTom Vanden BergheSven M. Francque et al.

A2 Journal Article in FRONTIERS IN MOLECULAR MEDICINE

Paneth cell TNF signaling induces gut bacterial translocation and sepsis

Charlotte WallaeysNatalia Garcia GonzalezSteven TimmermansJolien VandewalleTineke VanderhaeghenSomara De BeulHester DufoorMelanie EggermontElise MoensVictor Bosteels et al.

A1 Journal Article in CELL HOST & MICROBE

2023

Spns2/S1P : it takes two to tango with inflammation and metabolic rewiring during sepsis

Tineke VanderhaeghenJolien VandewalleClaude Libert

Editorial material

The impact of hepatocyte-specific deletion of hypoxia-inducible factors on the development of polymicrobial sepsis with focus on GR and PPARα function

Tineke VanderhaeghenSteven TimmermansMelanie EggermontDeepika WattsJolien VandewalleCharlotte WallaeysLouise NuyttensJoyca De TemmermanTino HochepiedSylviane Dewaele et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

The pig as a translational animal model to explore a new concept in the treatment of sepsis, today's largest unmet medical need

Fëllanza HalimiCharlotte CuypersBruna AlonsoEline HermansDiethard ReckelbusJolien VandewalleB. GarciaA. HerpainTineke VanderhaeghenCéline Van Dender et al.

The pig as a translational animal to explore a new concept in the treatment of sepsis, today's largest unmet medical need

Fëllanza HalimiCharlotte CuypersBruna AlonsoEline HermansDiethard ReckelbusJolien VandewalleBruno GarciaAntoine HerpainTineke VanderhaeghenCéline Van Dender et al.

2022

Hepatic peroxisome proliferator-activated receptor alpha dysfunction in porcine septic shock

Jolien VandewalleBruno GarciaSteven TimmermansTineke VanderhaeghenLise Van WyngeneMelanie EggermontHester DufoorCéline Van DenderFëllanza HalimiSiska Croubels et al.

A1 Journal Article in CELLS

Point mutation I634A in the glucocorticoid receptor causes embryonic lethality by reduced ligand binding

Steven TimmermansNicolette J.D. VerhoogKelly Van LooverenSylviane DewaeleTino HochepiedMelanie EggermontBarbara GilbertAnne Boerema-de MunckTineke VanderhaeghenJoke Vanden Berghe et al.

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Reprogramming of glucocorticoid receptor function by hypoxia

Tineke VanderhaeghenSteven TimmermansDeepika WattsVille PaakinahoMelanie EggermontJolien VandewalleCharlotte WallaeysLise Van WyngeneKelly Van LooverenLouise Nuyttens et al.

A1 Journal Article in EMBO REPORTS

2021

Bidirectional crosstalk between hypoxia inducible factors and glucocorticoid signalling in health and disease

Tineke VanderhaeghenRudi BeyaertClaude Libert

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Combined glucocorticoid resistance and hyperlactatemia contributes to lethal shock in sepsis

Jolien VandewalleSteven TimmermansVille PaakinahoLies VancraeynestLiza DewyseTineke VanderhaeghenCharlotte WallaeysLise Van WyngeneKelly Van LooverenLouise Nuyttens et al.

A1 Journal Article in CELL METABOLISM

The effect of hypoxia and hypoxia inducible factors on the glucocorticoid receptor function and their role during sepsis

Tineke VanderhaeghenClaude LibertRudi Beyaert

Turning a pathogen protein into a therapeutic tool for sepsis

Tineke VanderhaeghenCharlotte WallaeysClaude Libert

Editorial material

ZBTB32 performs crosstalk with the glucocorticoid receptor and is crucial in glucocorticoid responses to starvation

Lise Van WyngeneTineke VanderhaeghenIoanna PettaSteven TimmermansKatrien CorbeelsBart Van der SchuerenJolien VandewalleKelly Van LooverenCharlotte WallaeysMelanie Eggermont et al.

A1 Journal Article in ISCIENCE

2020

Glucocorticoids limit lipopolysaccharide-induced lethal inflammation by a double control system

Kelly Van LooverenSteven TimmermansTineke VanderhaeghenCharlotte WallaeysMarlies BallegeerJolien SouffriauMelanie EggermontJolien VandewalleLise Van WyngeneKarolien De Bosscher et al.

A1 Journal Article in EMBO REPORTS

Hepatic PPARα function and lipid metabolic pathways are dysregulated in polymicrobial sepsis

Lise Van WyngeneTineke VanderhaeghenSteven TimmermansJolien VandewalleKelly Van LooverenJolien SouffriauCharlotte WallaeysMelanie EggermontSam ErnstEvelien Van Hamme et al.

A1 Journal Article in EMBO MOLECULAR MEDICINE

Hypoxia-inducible factors in metabolic reprogramming during sepsis

Tineke VanderhaeghenJolien VandewalleClaude Libert

A1 Journal Article in FEBS JOURNAL

Taking the STING out of sepsis?

Jolien VandewalleTineke VanderhaeghenRudi BeyaertClaude Libert

Editorial material

Zinc inhibits lethal inflammatory shock by preventing microbe-induced interferon signature in intestinal epithelium

Jolien SouffriauSteven TimmermansTineke VanderhaeghenCharlotte WallaeysKelly Van LooverenLindsy AelbrechtSylviane DewaeleJolien VandewalleEvy GoossensSerge Verbanck et al.

A1 Journal Article in EMBO MOLECULAR MEDICINE

2019

TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile

Karen DendonckerSteven TimmermansJolien VandewalleMelanie EggermontJoanna LempiäinenVille PaakinahoEvelien Van HammeSylviane DewaeleSofie VandevyverMarlies Ballegeer et al.

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

2018

Using the inbred mouse strain SPRET/EiJ to provide novel insights in inflammation and infection research

Steven TimmermansJolien SouffriauJolien VandewalleLise Van WyngeneKelly Van LooverenTineke VanderhaeghenClaude Libert

A1 Journal Article in MAMMALIAN GENOME