Research Explorer

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Researcher

Tine Decruy

Awards & Distinctions

29 Results

2024

Tregs protect against invariant NKT cell-mediated autoimmune colitis and hepatitis

Koen VenkenTine DecruyTim SparwasserDirk Elewaut

A1 Journal Article in IMMUNOLOGY

2023

Distinct immune modulatory roles of regulatory T cells in gut versus joint inflammation in TNF-driven spondyloarthritis

Koen VenkenMatthias JarlborgTine DecruyCéline MortierCarolien VliegheElisabeth GilisAnn-Sophie De CraemerJulie CoudenysIsabelle CambréDevan Fleury et al.

A1 Journal Article in ANNALS OF THE RHEUMATIC DISEASES

GDF15 mediates inflammation-associated bone loss through a brain-bone axis

Renée Van der CruyssenJan DevanIrina HeggliDominik BurriDjoere GaublommeIván JosipovicEmilie DumasCarolien VliegheMaria Gabriella RaimondoPavel Zakharov et al.

Gut inflammation in axial spondyloarthritis patients is characterized by a marked type 17 skewed mucosal innate‐like T cell signature

Céline MortierKatrien QuintelierAnn-Sophie De CraemerThomas RensonLiselotte DerooEmilie DumasEveline VerheugenJulie CoudenysTine DecruyZuzanna Łukasik et al.

A1 Journal Article in ARTHRITIS & RHEUMATOLOGY

ROR gamma t inhibition ameliorates IL-23 driven experimental psoriatic arthritis by predominantly modulating gamma delta-T cells

Céline MortierEric GraceyJulie CoudenysTeddy ManuelloTine DecruyMargaux MaelegheerFlore StappersElisabeth GilisDjoere GaublommeLuc Van Hoorebeke et al.

A1 Journal Article in RHEUMATOLOGY

Transport by circulating myeloid cells drives liposomal accumulation in inflamed synovium

Joke DeprezRein VerbekeSofie MeulewaeterIlke AernoutHeleen DewitteTine DecruyJulie CoudenysJulie Van DuyseGert Van IsterdaelDan Peer et al.

A1 Journal Article in NATURE NANOTECHNOLOGY

2022

Evaluation of liposome-loaded microbubbles as a theranostic tool in a murine collagen-induced arthritis model

Joke DeprezSilke RooversGuillaume LajoinieHeleen DewitteTine DecruyJulie CoudenysBenedicte DescampsChristian VanhoveMichel VersluisDirk Elewaut et al.

A2 Journal Article in SCIENTIA PHARMACEUTICA

2020

A role for iNKT cells in sarcopenia

Anton De SpiegeleerHasan KahyaNele Van Den NoortgateEvelien WynendaeleTine DecruySrinath GovindarajanDirk Elewaut

An unexpected role for iNKT cells in skeletal muscle homeostasis

Anton De SpiegeleerHasan KahyaNele Van Den NoortgateEvelien WynendaeleTine DecruySrinath GovindarajanDirk Elewaut

2019

4''-O-Alkylated α-galactosylceramide analogues as iNKT-cell antigens : synthetic, biological, and structural studies

Jonas JanssensAruna BitraJing WangTine DecruyKoen VenkenJohan Van der EyckenDirk ElewautDirk ZajoncSerge Van Calenbergh

A1 Journal Article in CHEMMEDCHEM

Deletion of mucosa-associated lymphoid tissue lymphoma translocation protein 1 in mouse T cells protects against development of autoimmune arthritis but leads to spontaneous osteoporosis

Elisabeth GilisDjoere GaublommeJens StaalKoen VenkenMaarten DhaenensStijn LambrechtJulie CoudenysTine DecruyNadia SchryversYasmine Driege et al.

A1 Journal Article in ARTHRITIS & RHEUMATOLOGY

RORγt inhibition selectively targets IL-17 producing iNKT and γδ-T cells enriched in Spondyloarthritis patients

Koen VenkenPeggy JacquesCéline MortierMark E. LabadiaTine DecruyJulie CoudenysKathleen HoytAnita L. WayneRobert HughesMichael Turner et al.

A1 Journal Article in NATURE COMMUNICATIONS

2018

4"-O-alkylated α-galactosylceramide analogues as iNKT cell antigens : synthetic, biological and structural studies

Jonas JanssensJing WangAruna BitraTine DecruyKoen VenkenJohan Van der EyckenDirk ElewautDirk ZajoncSerge Van Calenbergh

2017

Efficient divergent synthesis of new immunostimulant 4″-modified α-galactosylceramide analogues

Jonas JanssensTine DecruyKoen VenkenToshiyuki SekiSimon KrolsJohan Van der EyckenMoriya TsujiDirk ElewautSerge Van Calenbergh

A1 Journal Article in ACS MEDICINAL CHEMISTRY LETTERS

Galactosylsphingamides : new α-GalCer analogues to probe the F’-pocket of CD1d

Joren GuillaumeJing WangJonas JanssensSoumya G RemeshMartijn RisseeuwTine DecruyMathy FroeyenDirk ElewautDirk M ZajoncSerge Van Calenbergh

A1 Journal Article in SCIENTIFIC REPORTS

Synthesis of C6′′-modified α-C-GalCer analogues as mouse and human iNKT cell agonists

Joren GuillaumeToshiyuki SekiTine DecruyKoen VenkenDirk ElewautMoriya TsujiSerge Van Calenbergh

A1 Journal Article in ORGANIC & BIOMOLECULAR CHEMISTRY

2014

A bidirectional crosstalk between iNKT cells and adipocytes mediated by leptin modulates susceptibility for T cell mediated hepatitis

Koen VenkenSylvie SeeuwsLennart ZabeauPeggy JacquesTine DecruyJulie CoudenysEveline VerheugenFien WindelsDominiek CatteeuwMichael Drennan et al.

A1 Journal Article in JOURNAL OF HEPATOLOGY

2013

Bacterial CD1d-restricted glycolipids induce IL-10 production by human regulatory T cells upon cross-talk with invariant NKT cells

Koen VenkenTine DecruySandrine AspeslaghSerge Van CalenberghBart LambrechtDirk Elewaut

A1 Journal Article in JOURNAL OF IMMUNOLOGY

2012

Selection of non-competitive leptin antagonists using a random nanobody-based approach

Lennart ZabeauAnnick VerheeDominiek CatteeuwLiesbeth FaesSylvie SeeuwsTine DecruyDirk ElewautFrank PeelmanJan Tavernier

A1 Journal Article in BIOCHEMICAL JOURNAL

2011

Galactose modified iNKT cell agonists stabilised by a novel structural modification of CD1D lead to marked TH1 polarisation in vivo

Sandrine AspeslaghYaLi LiEsther Dawen YuNora PauwelsMatthias TrappeniersEnrico GirardiTine DecruyKatrien Van BenedenKoen VenkenMichael Drennan et al.

Galactose-modified iNKT cell agonists stabilized by an induced fit of CD1d prevent tumour metastasis

Sandrine AspeslaghYali LiEsther Dawen YuNora PauwelsMatthias TrappeniersEnrico GirardTine DecruyKatrien Van BenedenKoen VenkenMichael Drennan et al.

A1 Journal Article in EMBO JOURNAL

2010

A multiparameter approach to monitor disease activity in collagen-induced arthritis

Sylvie SeeuwsPeggy JacquesJens Van PraetMichael DrennanJulie CoudenysTine DecruyEllen DeschepperLien LepescheuxPhilippe PujuguetLine Oste et al.

A1 Journal Article in ARTHRITIS RESEARCH & THERAPY

Optimizing the iNKT cell dependent antitumor effect using an altered glycolipid

Sandrine AspeslaghYali LiTine DecruyKatrien Van BenedenKoen VenkenMatthias TrappeniersSerge Van CalenberghDirk ZajoncDirk Elewaut

Optimizing the iNKT cell dependent antitumor effect using an altered glycolipid

Sandrine AspeslaghYali LiTine DecruyKatrien Van BenedenMichael DrennanKoen VenkenMatthias TrappeniersSerge Van CalenberghDirk ZajoncDirk Elewaut

Suppression of human natural killer T cell function by CD4(+)CD25(+)FOXP3(+) regulatory T cells

Koen VenkenTine DecruyKim DeswarteSandrine AspeslaghSerge Van CalenberghBart LambrechtDirk Elewaut

2009

The synthesis and in vivo evaluation of 2',2'-difluoro KRN7000

Leo LeungCyrille TomassiKatrien Van BenedenTine DecruyMatthias TrappeniersDirk ElewautYifang GaoTim ElliottAymen Al-ShamkhaniChristian Ottensmeier et al.

A1 Journal Article in CHEMMEDCHEM

2008

6'-Derivatised α-GalCer analogues capable of inducing strong CD1d-mediated Th1-biased NKT cell responses in mice

Matthias TrappeniersKatrien Van BenedenTine DecruyBruno LinclauDirk ElewautSerge Van Calenbergh

A1 Journal Article in JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis and in vitro evaluation of α-GalCer epimers

Matthias TrappeniersStijn GoormansKatrien Van BenedenTine DecruyBruno LinclauAymen Al-ShamkhaniTim ElliottChristian OttensmeierJoern M. WernerDirk Elewaut et al.

A1 Journal Article in CHEMMEDCHEM

Synthesis and in vivo evaluation of 4-Deoxy-4,4-difluoro-KRN7000

L LeungC TomassiKatrien Van BenedenTine DecruyDirk ElewautT ElliottA Al-ShamkhaniC OttensmeierSerge Van CalenberghJ Werner et al.

A1 Journal Article in ORGANIC LETTERS