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Tim Lammens
Profile
Projects
Publications & Research Data
Activities
Awards & Distinctions
Patents
180
Resultaten
2026
Decoding NOTCH1 : from T-cell development guardian to driver of pediatric T-cell lymphoblastic lymphoma
Fran Leijnen
Tim Lammens
A1
Journal Article
in
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
2026
Targeting replication stress in neuroblastoma by exploiting the synergistic potential of second generation RRM2 and CHK1 inhibitors
Iris Nelen
Soetkin Leys
Sarah-Lee Bekaert
Fanny De Vloed
Fien Martens
Ellen Sanders
Angeline Praveena Enton Raj
Annika Jeschke
Shunya Ohmura
Thomas G P Grünewald
et al.
A1
Journal Article
in
CELL DEATH & DISEASE
2026
2025
A human-like glutaminase-free asparaginase is highly efficacious in ASNS-low leukemia and solid cancer mouse xenograft models
Maaike Van Trimpont
Amanda M. Schalk
Kenneth Hofkens
Evelien Peeters
Sara T'Sas
Katrien Vandemeulebroecke
Ying Su
Ashley De Loera
Alyssa Garcia
Hui Chen
et al.
A1
Journal Article
in
CANCER LETTERS
2025
ALLTogether recommendations for biobanking samples from patients with acute lymphoblastic leukaemia : a modified Delphi study
Amélie Trinquand
James Leveson
Ana Lúcia Barbosa
Paula Gameiro
Tiina Vesterinen
Tim Lammens
Thomas Drost
Anthony V. Moorman
Valérie de Haas
Jonathan Bond
et al.
A1
Journal Article
in
BRITISH JOURNAL OF CANCER
2025
Exploring germline variants in genes associated with inborn errors of immunity and inherited bone marrow failure syndromes in pediatric hematological malignancies
Jette J. Bakhuizen
Freerk van Dijk
Sebastian B.B. Bon
Lars T. van der Veken
Manon M.H. Huibers
Joris M. van Montfrans
Marieke De Bruyne
Barbara De Moerloose
Filomeen Haerynck
Jan L.C. Loeffen
et al.
A1
Journal Article
in
EUROPEAN JOURNAL OF CANCER
2025
Exploring the pathobiology and therapeutic horizons of pediatric acute myeloid leukemia
Jolien Vanhooren
Tim Lammens
Barbara De Moerloose
Jan Gettemans
Dissertation
2025
HNRNPC and m6A RNA methylation control oncogenic transcription and metabolism in T-cell leukemia
Jonas De Kesel
Igor Fijalkowski
Tim Pieters
Cristina Borin
Kasper Thorhauge Christensen
Manou Wittouck
Jolien Van Laere
Laura Guerrero
Lindy Reunes
Marino Caruso
et al.
A1
Journal Article
in
BLOOD
2025
Involvement of THBS1 in myeloid sarcoma of acute myeloid leukemia
Zhiyao Ren
Jolien Vanhooren
Barbara De Moerloose
Tim Lammens
Editorial material
2025
Nidogen-1, a player in KMT2A-rearranged pediatric acute myeloid leukemia
Jolien Vanhooren
Larissa Deneweth
Luca Pagliaro
Zhiyao Ren
Mariateresa Giaimo
Rafaella Zamponi
Giovanni Roti
Barbara Depreter
Mattias Hofmans
Barbara De Moerloose
et al.
A1
Journal Article
in
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
2025
Peptide hydrogels as slow-release formulations of protein therapeutics : case study of asparaginase-loaded hydrogels
Hue Vu
Evelien Peeters
Kenneth Hofkens
Katrien Vandemeulebroecke
Sara T'Sas
Charlotte Martin
Steven Ballet
Richard Hoogenboom
Steven Goossens
Tim Lammens
et al.
A1
Journal Article
in
BIOMATERIALS SCIENCE
2025
Prime-time for IncRNA signatures in acute myeloid leukaemia?
Z Ren
Barbara De Moerloose
Tim Lammens
A2
Journal Article
in
BELGIAN JOURNAL OF HEMATOLOGY
2025
Prime-time for LncRNA signatures in acute myeloid leukemia?
Zhiyao Ren
Barbara De Moerloose
Tim Lammens
A1
Journal Article
in
ANNALS OF HEMATOLOGY
2025
Profiling histone post-translational modifications to identify signatures of epigenetic drug response in T-cell acute lymphoblastic leukemia
Laura Corveleyn
Lien Provez
Osman Satilmis
Nina Refhagen
Mattias Landfors
Wouter Sleeckx
Béatrice Lintermans
Amélie De Maesschalck
Rishi S. Kotecha
Barbara De Moerloose
et al.
Preprint
2025
Underlying biology, challenges and emergent concepts in the treatment of relapsed and refractory pediatric T-cell acute lymphoblastic leukemia
Patrícia Amaral
Rhona Christie
Daisy O. F. Gresham
Emma J. M. Lucas
Luyao Kevin Xu
Lena Behrmann
Jonathan Bond
Sofie Degerman
Frederik W. van Delft
Steven Goossens
et al.
A1
Journal Article
in
LEUKEMIA
2025
2024
A 69 long non-coding RNAs expression signature predicts relapse and acts as an independent prognostic factor in pediatric acute myeloid leukemia
Zhiyao Ren
Jolien Vanhooren
Charlotte Derpoorter
Barbara De Moerloose
Tim Lammens
C3
Conference
2024
A 69 long noncoding RNA signature predicts relapse and acts as independent prognostic factor in pediatric AML
Zhiyao Ren
Jolien Vanhooren
Charlotte Derpoorter
Barbara De Moerloose
Tim Lammens
A1
Journal Article
in
BLOOD ADVANCES
2024
Genetic testing for childhood cancer predisposition syndromes : controversies and recommendations from the SIOPE Host Genome Working Group meeting 2022
Jette J. Bakhuizen
Franck Bourdeaut
Karin A.W. Wadt
Christian P. Kratz
Marjolijn C.J. Jongmans
Nicolas Waespe
Sabine Hellemans
Sophie Van Hoyweghen
Tim Lammens
Charlotte Derpoorter
et al.
A2
Journal Article
in
EJC PAEDIATRIC ONCOLOGY
2024
Ikaros loss enhances pre-leukemic thymocyte self-renewal and drives T-all in mice
Maaike Van Trimpont
Sara T'Sas
Tim Lammens
Pieter Van Vlierberghe
Tim Pieters
Steven Goossens
C3
Conference
2024
Long non-coding RNAs in neuroblastoma : pathogenesis, biomarkers and therapeutic targets
Niels Vercouillie
Zhiyao Ren
Eva Terras
Tim Lammens
A1
Journal Article
in
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
2024
Nidogen-1, a novel player in KMT2A-rearranged pediatric acute myeloid leukemia patients, expressed in the leukemic stem cell
Jolien Vanhooren
Larissa Deneweth
Luca Pagliaro
Zhiyao Ren
Barbara Depreter
Mattias Hofmans
Barbara De Moerloose
Tim Lammens
C3
Conference
2024
PDXGhent : patient derived tumor xenografting mouse core facility Ghent
Liselot Mus
Steven Goossens
Tim Lammens
Lindsey Devisscher
Panagiotis Ntziachristos
Olivier De Wever
Frédéric Clement
C3
Conference
2024
PDXGhent : patient derived tumor xenografting mouse Core Facility Ghent
Liselot Mus
Steven Goossens
Tim Lammens
Lindsey Devisscher
Panagiotis Ntziachristos
Olivier De Wever
Frédéric Clement
C3
Conference
2024
Precision medicine in relapsed and refractory paediatric haematological malignancies and the role of an international tumour board
Alexandra Reekmans
Uri Ilan
Judith M Boer
Tim Lammens
Steven Goossens
C Michel Zwaan
Monique L den Boer
Barbara De Moerloose
A2
Journal Article
in
BELGIAN JOURNAL OF HEMATOLOGY
2024
Targeting hyperactive platelet-derived growth factor receptor-β signaling in T-cell acute lymphoblastic leukemia and lymphoma
Stien De Coninck
Renate De Smedt
Béatrice Lintermans
Lindy Reunes
Hansen J. Kosasih
Alexandra Reekmans
Lauren M. Brown
Nadine Van Roy
Bruno Palhais
Juliette Roels
et al.
A1
Artikel in een tijdschrift
in
HAEMATOLOGICA
2024
Ultra-deep sequencing and single cell multi-omics characterize measurable residual disease and identify therapy-survived clone in pediatric acute myeloid leukemia
Borhan R. R Saeed
Anastasia Saboli
Anna Rehammar
Adam Molnar
Erik Delsing Malmberg
Barbara Depreter
Giti Shah Barkhordar
Barbara De Moerloose
Tim Lammens
Lars Palmqvist
et al.
C3
Conferentie
2024
2023
A 46 long non-coding RNAs expression signature accurately predicts relapse and acts as an independent prognostic factor in pediatric acute myeloid leukemia
Zhiyao Ren
Jolien Vanhooren
Charlotte Derpoorter
Barbara De Moerloose
Tim Lammens
C3
Conferentie
2023
A novel mammalian L-asparaginase with no L-glutaminase activity is highly efficacious against T-cell acute lymphoblastic leukemia in vivo
Maaike Van Trimpont
Amanda Schalk
Evelien Peeters
Tim Lammens
Steven Goossens
Arnon Lavie
Pieter Van Vlierberghe
C3
Conferentie
2023
A role for IKZF1 in pre-leukemic T-all?
Maaike Van Trimpont
Tim Lammens
Steven Goossens
Pieter Van Vlierberghe
C3
Conferentie
2023
CAR-T in the treatment of acute myeloid leukemia : barriers and how to overcome them
Jolien Vanhooren
Rani Dobbelaere
Charlotte Derpoorter
Larissa Deneweth
Laurens Van Camp
Anne Uyttebroeck
Barbara De Moerloose
Tim Lammens
A1
Artikel in een tijdschrift
in
HEMASPHERE
2023
Childhood cancer predisposition : exploring mising heritability using DNA sequencing approaches
Charlotte Derpoorter
Tim Lammens
Genevieve Laureys
Proefschrift
2023
Drug response profiling informs personalized bridging to cell therapy for patients with relapsed/refractory acute lymphoblastic leukemia
Fabio D. Steffen
Andrej Lissat
Julia Alten
Cornelia Eckert
Bodmer Nicole
Thorhauge Als-Nielsen Bodil E.
Adriana Balduzzi
Sarah Elitzur
Andras Kriston
Gergely Nyiri
et al.
C3
Conferentie
2023
European standard clinical practice : key issues for the medical care of individuals with familial leukemia
Alisa Förster
Claudia Davenport
Nicolas Duployez
Miriam Erlacher
Alina Ferster
Jude Fitzgibbon
Gudrun Göhring
Henrik Hasle
Marjolijn C. Jongmans
Alexandra Kolenova
et al.
A1
Artikel in een tijdschrift
in
EUROPEAN JOURNAL OF MEDICAL GENETICS
2023
In vivo stabilization of a less toxic asparaginase variant leads to a durable antitumor response in acute leukemia
Maaike Van Trimpont
Amanda M. Schalk
Yanti De Visser
Hien Anh Nguyen
Lindy Reunes
Katrien Vandemeulebroecke
Evelien Peeters
Ying Su
Hyun Lee
Philip L. Lorenzi
et al.
A1
Artikel in een tijdschrift
in
HAEMATOLOGICA
2023
TEARDRoP : Team EARly DRug development in Paediatric oncology
Liselot Mus
Bram De Wilde
Tim Lammens
C3
Conferentie
2023
Whole genome sequencing and inheritance-based variant filtering as a tool for unraveling missing heritability in pediatric cancer
Charlotte Derpoorter
Ruben Van Paemel
Katrien Vandemeulebroecke
Jolien Vanhooren
Bram De Wilde
Genevieve Laureys
Tim Lammens
A1
Artikel in een tijdschrift
in
PEDIATRIC HEMATOLOGY AND ONCOLOGY
2023
2022
A clinically annotated post-mortem approach to study multi-organ somatic mutational clonality in normal tissues
Tom Luijts
Kerryn Elliott
Joachim Siaw
Joris Van de Velde
Elien Beyls
Arne Claeys
Tim Lammens
Erik Larsson
Wouter Willaert
Anne Vral
et al.
A1
Artikel in een tijdschrift
in
SCIENTIFIC REPORTS
2022
Correction to : functional classification of RUNX1 variants in familial platelet disorder with associated myeloid malignancies
Melanie Decker
Tim Lammens
Alina Ferster
Miriam Erlacher
Ayami Yoshimi
Charlotte M. Niemeyer
Martijn P. T. Ernst
Marc H. G. P. Raaijmakers
Nicolas Duployez
Andreas Flaum
et al.
Correctie
2022
Deciphering the non-coding landscape of pediatric acute myeloid leukemia
Laurens Van Camp
Jolien Vanhooren
Barbara Depreter
Martijn de Jong
Anne Uyttebroeck
An Van Damme
Laurence Dedeken
Marie-Françoise Dresse
Jutte van der Werff ten Bosch
Mattias Hofmans
et al.
C3
Conferentie
2022
Deciphering the non-coding landscape of pediatric acute myeloid leukemia
Jolien Vanhooren
Laurens Van Camp
Barbara Depreter
Martijn de Jong
Anne Uyttebroeck
An Van Damme
Laurence Dedeken
Marie-Françoise Dresse
Jutte van der Werff ten Bosch
Mattias Hofmans
et al.
C3
Conferentie
2022
Deciphering the non-coding RNA landscape of pediatric acute myeloid leukemia
Jolien Vanhooren
Laurens Van Camp
Barbara Depreter
Martijn de Jong
Anne Uyttebroeck
An Van Van Damme
Laurence Dedeken
Marie-Françoise Dresse
Jutte van der Werff ten Bosch
Mattias Hofmans
et al.
A1
Artikel in een tijdschrift
in
CANCERS
2022
Evaluation of PEG-L-asparaginase in asparagine suppression and anti-drug antibody development in healthy Beagle dogs : a multi-phase preclinical study
L.R. Feenstra
R. Gehring
I.M. van Geijswijk
T. König
H.C.M.T Prinsen
Katrien Vandemeulebroecke
Tim Lammens
Adriana Krupa
E. Teske
A1
Artikel in een tijdschrift
in
VETERINARY JOURNAL
2022
Mutational permutations of a single amino acid exert divergent phenotypic effects in human, mice and cellular models of SAMD9L bone marrow failure disorder
Sushree S Sahoo
Charnise Goodings-Harris
Shondra Miller
Maria Angeles Lillo Osuna
Baranda S Hansen
Lei Han
Ti-Cheng Chang
Tim Lammens
Mattias Hofmans
Marta Derecka
et al.
C3
Conferentie
2022
Novel insights on the use of L-asparaginase as an efficient and safe anti-cancer therapy
Maaike Van Trimpont
Evelien Peeters
Yanti De Visser
Amanda M. Schalk
Veerle Mondelaers
Barbara De Moerloose
Arnon Lavie
Tim Lammens
Steven Goossens
Pieter Van Vlierberghe
A1
Artikel in een tijdschrift
in
CANCERS
2022
Optimization of asparaginase therapy in childhood acute lymphoblastic leukemia
Veerle Mondelaers
Barbara De Moerloose
Tim Lammens
Proefschrift
2022
Practice guidelines for the therapeutic drug monitoring of asparaginase in acute lymphoblastic leukemia
Veerle Mondelaers
Tim Lammens
Martijn de Jong
Larissa Deneweth
Katrien Vandemeulebroecke
Barbara De Moerloose
A2
Artikel in een tijdschrift
in
BELGIAN JOURNAL OF HEMATOLOGY
2022
Predicting outcomes with circulating adrenergic neuroblastoma mRNAs in children with relapsed and refractory neuroblastoma : a BEACON-Neuroblastoma biomarker study
Lucas Moreno
Rebekah Weston
Virginie Viprey
Andrei Tchirkov
Maria Corrias
Tim Lammens
Juliet Gray
Cormac Owens
Jennifer Laidler
Marion Gambart
et al.
C3
Conferentie
2022
Targeted therapy in juvenile myelomonocytic leukemia : where are we now?
Nele De Vos
Mattias Hofmans
Tim Lammens
Bram De Wilde
Nadine Van Roy
Barbara De Moerloose
A1
Artikel in een tijdschrift
in
PEDIATRIC BLOOD & CANCER
2022
The feasibility of using liquid biopsies as a complementary assay for copy number aberration profiling in routinely collected paediatric cancer patient samples
Ruben Van Paemel
Charlotte Vandeputte
Lennart Raman
Jolien Van Thorre
Leen Willems
Jo Van Dorpe
Malaïka Van der Linden
Jilke De Wilde
Andries De Koker
Björn Menten
et al.
A1
Artikel in een tijdschrift
in
EUROPEAN JOURNAL OF CANCER
2022
Tracking the molecular fingerprint of head and neck cancer for recurrence detection in liquid biopsies
Araceli Diez-Fraile
Joke De Ceulaer
Charlotte Derpoorter
Christophe Spaas
Tom De Backer
Philippe Lamoral
Johan Abeloos
Tim Lammens
A1
Artikel in een tijdschrift
in
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
2022
2021
CircRNAs dysregulated in juvenile myelomonocytic leukemia : CircMCTP1 stands out
Anna Dal Molin
Mattias Hofmans
Enrico Gaffo
Alessia Buratin
Hélène Cavé
Christian Flotho
Valerie de Haas
Charlotte M. Niemeyer
Jan Stary
Pieter Van Vlierberghe
et al.
A1
Artikel in een tijdschrift
in
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
2021
Circulating non-coding RNAs in head and neck cancer : roles in diagnosis, prognosis, and therapy monitoring
Araceli Diez-Fraile
Joke De Ceulaer
Charlotte Derpoorter
Christophe Spaas
Tom De Backer
Philippe Lamoral
Johan Abeloos
Tim Lammens
A1
Artikel in een tijdschrift
in
CELLS
2021
Current developments and hurdles in CAR-T cell therapy for acute myeloid leukaemia
Laurens Van Camp
Tim Lammens
Anne Uyttebroeck
Barbara De Moerloose
A2
Artikel in een tijdschrift
in
BELGIAN JOURNAL OF HEMATOLOGY
2021
Deciphering molecular heterogeneity in pediatric AML using a cancer vs. normal transcriptomic approach
Barbara Depreter
Barbara De Moerloose
Karl Vandepoele
Anne Uyttebroeck
An Van Damme
Eva Terras
Barbara Denys
Laurence Dedeken
Marie-Francoise Dresse
Jutte Van der Werff Ten Bosch
et al.
A1
Artikel in een tijdschrift
in
PEDIATRIC RESEARCH
2021
Favorable outcome of NUTM1-rearranged infant and pediatric B cell precursor acute lymphoblastic leukemia in a collaborative international study
Judith M. Boer
Maria Grazia Valsecchi
Femke M. Hormann
Željko Antić
Marketa Zaliova
Claire Schwab
Giovanni Cazzaniga
Chloé Arfeuille
Hélène Cavé
Andishe Attarbaschi
et al.
A1
Artikel in een tijdschrift
in
LEUKEMIA
2021
Functional classification of RUNX1 variants in familial platelet disorder with associated myeloid malignancies
Melanie Decker
Tim Lammens
Alina Ferster
Miriam Erlacher
Ayami Yoshimi
Charlotte M. Niemeyer
Martijn P. T. Ernst
Marc H. G. P. Raaijmakers
Nicolas Duployez
Andreas Flaum
et al.
A1
Artikel in een tijdschrift
in
LEUKEMIA
2021
Germline SAMD9L triple-allelic mosaicism with independent segregation into biallelic offsprings : molecular support for non-mendelian inheritance
S Sahoo
C Goodings
M Angeles Lillo
Tim Lammens
J van der Werff ten Bosch
B Strahm
Barbara De Moerloose
M Wlodarski
C3
Conferentie
2021
Long non-coding RNAs as novel therapeutic targets in juvenile myelomonocytic leukemia
Mattias Hofmans
Tim Lammens
Barbara Depreter
Ying Wu
Miriam Erlacher
Aurélie Caye
Hélène Cavé
Christian Flotho
Valerie de Haas
Charlotte M. Niemeyer
et al.
A1
Artikel in een tijdschrift
in
SCIENTIFIC REPORTS
2021
Minimally invasive classification of pediatric solid tumors using reduced representation bisulfite sequencing of cell-free DNA : a proof-of-principle study
Ruben Van Paemel
Andries De Koker
Charlotte Vandeputte
Lieke van Zogchel
Tim Lammens
Genevieve Laureys
Jo Vandesompele
Gudrun Schleiermacher
Mathieu Chicard
Nadine Van Roy
et al.
A1
Artikel in een tijdschrift
in
EPIGENETICS
2021
Novel therapeutic targets in juvenile myelomonocytic leukaemia : are noncoding RNAs valuable treatment options?
Mattias Hofmans
Tim Lammens
Jan Philippé
Barbara De Moerloose
A2
Artikel in een tijdschrift
in
BELGIAN JOURNAL OF HEMATOLOGY
2021
Novel therapeutic targets in juvenile myelomonocytic leukemia : are noncoding RNAs valuable treatment options?
Mattias Hofmans
Barbara De Moerloose
Jan Philippé
Tim Lammens
Proefschrift
2021
RUNX2 regulates leukemic cell metabolism and chemotaxis in high-risk T cell acute lymphoblastic leukemia
Filip Matthijssens
Nitesh D. Sharma
Monique Nysus
Christian K. Nickl
Huining Kang
Dominique R. Perez
Béatrice Lintermans
Wouter Van Loocke
Juliette Roels
Sofie Peirs
et al.
A1
Artikel in een tijdschrift
in
JOURNAL OF CLINICAL INVESTIGATION
2021
TARP as antigen in cancer immunotherapy
Jolien Vanhooren
Charlotte Derpoorter
Barbara Depreter
Larissa Deneweth
Jan Philippé
Barbara De Moerloose
Tim Lammens
A1
Artikel in een tijdschrift
in
CANCER IMMUNOLOGY IMMUNOTHERAPY
2021
2020
Aging of preleukemic thymocytes drives CpG island hypermethylation in T-cell acute lymphoblastic leukemia
Juliette Roels
Morgan Thénoz
Bronislawa Szarzynska
Mattias Landfors
Stien De Coninck
Lisa Demoen
Lien Provez
Anna Kuchmiy
Steven Strubbe
Lindy Reunes
et al.
C3
Conferentie
2020
Aging of preleukemic thymocytes drives CpG island hypermethylation in T-cell acute lymphoblastic leukemia
Juliette Roels
Morgan Thénoz
B Szarzyńska
M Landfors
Stien De Coninck
Lisa Demoen
Lien Provez
Anna Kuchmiy
Steven Strubbe
Lindy Reunes
et al.
A2
Artikel in een tijdschrift
in
BLOOD CANCER DISCOVERY
2020
Clinical significance of TARP expression in pediatric acute myeloid leukemia
B. Depreter
Barbara De Moerloose
Karl Vandepoele
A. Uyttebroeck
A. Van Damme
B. Denys
L. Dedeken
M. -F. Dresse
J. Van der Werff Ten Bosch
M. Hofmans
et al.
C3
Conferentie
2020
Clinical significance of TARP expression in pediatric acute myeloid leukemia
Barbara Depreter
Barbara De Moerloose
Karl Vandepoele
Anne Uyttebroeck
An Van Damme
Barbara Denys
Laurence Dedeken
Marie-Françoise Dresse
Jutte Van Der Werff Ten Bosch
Mattias Hofmans
et al.
A1
Artikel in een tijdschrift
in
HEMASPHERE
2020
Exploring the molecular and phenotypical heterogeneity between patients with pediatric acute myeloid leukemia
Barbara Depreter
Tim Lammens
Jan Philippé
Proefschrift
2020
In vitro characterization of hippo signaling in hematological childhood malignancies
Charlotte Derpoorter
Jolien Vanhooren
Larissa Deneweth
Katrien Vandemeulebroecke
Genevieve Laureys
Tim Lammens
C3
Conferentie
2020
Leukaemic stem cells in AML : where are we now? An update on recent findings and detection
Barbara Depreter
Barbara De Moerloose
Jan Philippé
Tim Lammens
A2
Artikel in een tijdschrift
in
BELGIAN JOURNAL OF HEMATOLOGY
2020
Minimally invasive classification of pediatric solid tumors using reduced representation bisulfite sequencing of cell-free DNA
Ruben Van Paemel
Andries De Koker
Charlotte Vandeputte
Lieke Van Zogchel
Tim Lammens
Genevieve Laureys
Jo Vandesompele
Gudrun Schleiermacher
Matthieu Chicard
Nadine Van Roy
et al.
C3
Conferentie
2020
NUTM1-rearranged infant and pediatric B cell precursor acute lymphoblastic leukemia : a good prognostic subtype identified in a collaborative international study
Judith M. Boer
Maria Grazia Valsecchi
Femke M. Hormann
Zeljko Antic
Marketa Zaliova
Claire Schwab
Giovanni Cazzaniga
Chloe Arfeuille
Helene Cave
Andishe Attarbaschi
et al.
C3
Conferentie
2020
Prospective, real-time monitoring of pegylated Escherichia coli and Erwinia asparaginase therapy in childhood acute lymphoblastic leukaemia and non-Hodgkin lymphoma in Belgium
Veerle Mondelaers
Alina Ferster
Anne Uyttebroeck
Benedicte Brichard
Juttevan der Werff ten Bosch
Koenraad Norga
Nadine Francotte
Caroline Piette
Katrien Vandemeulebroecke
Charlotte Verbeke
et al.
A1
Artikel in een tijdschrift
in
BRITISH JOURNAL OF HAEMATOLOGY
2020
Retrospective analysis of the incidence and characteristics of paediatric myelodysplastic syndrome and juvenile myelomonocytic leukaemia in Belgium
Lindsey De Smaele
Mattias Hofmans
Tim Lammens
A Van Damme
Jutte van der Werff ten Bosch
A Ferster
Joris Verlooy
C Chantrain
Jan Philippé
Nadine Van Roy
et al.
A2
Artikel in een tijdschrift
in
BELGIAN JOURNAL OF HEMATOLOGY
2020
Targeting cytokine- and therapy-induced PIM1 activation in preclinical models of T-cell acute lymphoblastic leukemia and lymphoma
Renate De Smedt
Julie Morscio
Lindy Reunes
Juliette Roels
Valentina Bardelli
Béatrice Lintermans
Wouter Van Loocke
Afonso Almeida
Laurence C. Cheung
Rishi S. Kotecha
et al.
A1
Artikel in een tijdschrift
in
BLOOD
2020
TARP is an immunotherapeutic target in acute myeloid leukemia expressed in the leukemic stem cell compartment
Barbara Depreter
Karin Weening
Karl Vandepoele
Magnus Essand
Barbara De Moerloose
Maria Themeli
Jacqueline Cloos
Diana Hanekamp
Ine Moors
INGE D'HONT
et al.
A1
Artikel in een tijdschrift
in
HAEMATOLOGICA
2020
The altered transcriptome of pediatric myelodysplastic syndrome revealed by RNA sequencing
L Zubovic
S Piazza
T Tebaldi
L Cozzuto
G Palazzo
V Sidarovich
V De Sanctis
R Bertorelli
Tim Lammens
Mattias Hofmans
et al.
A1
Artikel in een tijdschrift
in
JOURNAL OF HEMATOLOGY & ONCOLOGY
2020
The EMT modulator SNAI1 contributes to AML pathogenesis via its interaction with LSD1
Catherine L. Carmichael
Jueqiong Wang
Thao Nguyen
Oluseyi Kolawole
Aissa Benyoucef
Charlotte De Mazière
Anna Milne
Sona Samuel
Kevin Robert Gillinder
Soroor Hediyeh-zadeh
et al.
A1
Artikel in een tijdschrift
in
BLOOD
2020
The interplay of parent and child coping responses in understanding child functioning in the context of living with a parent with or without chronic pain
Elke Van Lierde
Liesbet Goubert
Tim Lammens
Lamia Ben Brahim
Eva Van den Bussche
Tine Vervoort
A1
Artikel in een tijdschrift
in
CLINICAL JOURNAL OF PAIN
2020
The pitfalls and promise of liquid biopsies for diagnosing and treating solid tumors in children : a review
Ruben Van Paemel
ROSALIE VLUG
Katleen De Preter
Nadine Van Roy
Franki Speleman
Leen Willems
Tim Lammens
Genevieve Laureys
Gudrun Schleiermacher
Godelieve AM Tytgat
et al.
A1
Artikel in een tijdschrift
in
EUROPEAN JOURNAL OF PEDIATRICS
2020
The pitfalls and promise of liquid biopsies for diagnosing and treating solid tumors in children : as review (vol 179, pg 191, 2020)
Ruben Van Paemel
Roos Vlug
Katleen De Preter
Nadine Van Roy
Franki Speleman
Leen Willems
Tim Lammens
Genevieve Laureys
Gudrun Schleiermacher
Godelieve A. M. Tytgat
et al.
Correctie
2020
2019
Deciphering molecular heterogeneity in pediatric AML using a cancer vs normal transcriptomic approach
Barbara Depreter
Mattias Hofmans
Eva Terras
Anne Uyttebroeck
An Van Damme
Alina Ferster
Jutte Van der Werff Ten Bosch
Marie-Françoise Dresse
Karl Vandepoele
Barbara De Moerloose
et al.
C3
Conferentie
2019
Deciphering molecular heterogeneity in pediatric AML using a cancer vs normal transcriptomic approach
Barbara Depreter
Mattias Hofmans
Eva Terras
Anne Uyttebroeck
An Van Damme
Alina Ferster
Jutte van der Werff ten Bosch
Marie-Françoise Dresse
Karl Vandepoele
Barbara De Moerloose
et al.
C3
Conferentie
2019
Genetic characterization and therapeutic targeting of MYC-rearranged T cell acute lymphoblastic leukaemia
Gloria Milani
Filip Matthijssens
Wouter Van Loocke
Kaat Durinck
Juliette Roels
Sofie Peirs
Morgan Thénoz
Tim Pieters
Lindy Reunes
Béatrice Lintermans
et al.
A1
Artikel in een tijdschrift
in
BRITISH JOURNAL OF HAEMATOLOGY
2019
Long non-coding RNAs as novel therapeutic targets in juvenile myelomonocytic leukemia : proof of concept study
Mattias Hofmans
Barbara Depreter
Tim Lammens
Helene Cave
Christian Flotho
Henrik Hasle
Valerie de Haas
Charlotte M. Niemeyer
Jan Stary
Pieter Van Vlierberghe
et al.
C3
Conferentie
2019
Minimally invasive classification of pediatric solid tumors using reduced representation bisulfite sequencing of cell-free DNA : a proof-of-principle study
Ruben Van Paemel
Andries De Koker
Charlotte Vandeputte
Lieke van Zogchel
Tim Lammens
Genevieve Laureys
Jo Vandesompele
Gudrun Schleiermacher
Mathieu Chicard
Nadine Van Roy
et al.
Preprint
2019
Non-invasive classification of pediatric tumor types using reduced representation bisulfite sequencing of cell-free DNA : a proof-of-principle study
Ruben Van Paemel
A. De Koker
Charlotte Vandeputte
L. M. J. van Zogchel
M. Chicard
Tim Lammens
Jo Vandesompele
Nadine Van Roy
G. Schleiermacher
G. A. M. Tytgat
et al.
C3
Conferentie
2019
Noonan syndrome-associated myeloproliferative disorder with somatically acquired monosomy 7 : impact on clinical decision making
Mattias Hofmans
Rieke Schroeder
Tim Lammens
Christian Flotho
Charlotte Niemeyer
Nadine Van Roy
Wim Decaluwe
Jan Philippé
Barbara De Moerloose
A1
Artikel in een tijdschrift
in
BRITISH JOURNAL OF HAEMATOLOGY
2019
Novel strategy for rapid functional in vivo validation of oncogenic drivers in haematological malignancies
Tim Pieters
Sara T'Sas
Lisa Demoen
André Pedro Pinto De Almeida
Lieven Haenebalcke
Filip Matthijssens
Kelly Lemeire
Jinke D'Hont
Frédérique Vanrockeghem
Tino Hochepied
et al.
A1
Artikel in een tijdschrift
in
SCIENTIFIC REPORTS
2019
Pinpointing a potential role for CLEC12B in cancer predisposition through familial exome sequencing
Charlotte Derpoorter
Karl Vandepoele
Araceli Diez Fraile
Katrien Vandemeulebroecke
Bram De Wilde
Franki Speleman
Nadine Van Roy
Tim Lammens
Genevieve Laureys
A1
Artikel in een tijdschrift
in
PEDIATRIC BLOOD & CANCER
2019
Response-guided chemotherapy for pediatric acute myeloid leukemia without hematopoietic stem cell transplantation in first complete remission: Results from protocol DB AML-01
Barbara De Moerloose
Ardine Reedijk
Geertruida H. de Bock
Tim Lammens
Valerie de Haas
Barbara Denys
Laurence Dedeken
Marry M. van den Heuvel-Eibrink
Maroeska te Loo
Anne Uyttebroeck
et al.
A1
Artikel in een tijdschrift
in
PEDIATRIC BLOOD & CANCER
2019
Shallow whole genome sequencing on circulating cell-free DNA in pediatric cancer patients
Charlotte Vandeputte
Jolien Van Thorre
Ruben Van Paemel
Andries De Koker
Leen Willems
Jo Van Dorpe
Malaïka Van der Linden
Jilke De Wilde
Björn Menten
L. van Zogchel
et al.
C3
Conferentie
2019
Shallow whole genome sequencing on circulating cell-free DNA in pediatric cancer patients
Charlotte Vandeputte
Jolien Van Thorre
Ruben Van Paemel
Andries De Koker
Leen Willems
Jo Van Dorpe
Malaïka Van der Linden
Jilke De Wilde
Björn Menten
Lieke van Zogchel
et al.
C3
Conferentie
2019
Shallow whole genome sequencing on circulating cell-free DNA in pediatric cancer patients
Charlotte Vandeputte
Jolien Van Thorre
Ruben Van Paemel
Andries De Koker
Leen Willems
Jo Van Dorpe
Malaïka Van der Linden
Jilke De Wilde
Björn Menten
Lieke van Zogchel
et al.
C3
Conferentie
2019
Successful copy number alteration profiling using circulating cell-free tumor DNA as a non-invasive alternative for tissue biopsies in pediatric cancer patients
Charlotte Vandeputte
Jolien Van Thorre
Ruben Van Paemel
Andries De Koker
Leen Willems
Jo Van Dorpe
Malaïka Van der Linden
Jilke De Wilde
Björn Menten
Lieke van Zogchel
et al.
C3
Conferentie
2019
TARP as immunotherapeutic target in AML expressed in the LSC compartment
Barbara Depreter
Karin Weening
Karl Vandepoele
M Essand
Barbara De Moerloose
M Themeli
J Cloos
D Hanekamp
Ine Moors
INGE D'HONT
et al.
C3
Conferentie
2019
2018
A novel L-asparaginase with low L-glutaminase coactivity is highly efficacious against both T- and B-cell acute lymphoblastic leukemias in vivo
Hien Anh Nguyen
Ying Su
Jenny Yu Zhang
Aleksandar Antanasijevic
Michael Caffrey
Amanda M Schalk
Li Liu
Damiano Rondelli
Annie Oh
Dolores L Mahmud
et al.
A1
Artikel in een tijdschrift
in
CANCER RESEARCH
2018
Cancer-related mRNA expression analysis using a novel flow cytometry-based assay
Barbara Depreter
Jan Philippé
MAGALI MEUL
Barbara Denys
Karl Vandepoele
Barbara De Moerloose
Tim Lammens
A1
Artikel in een tijdschrift
in
CYTOMETRY PART B-CLINICAL CYTOMETRY
2018
Circulating microRNA biomarkers for metastatic disease in neuroblastoma patients
Fjoralba Zeka
Anneleen Decock
Alan Van Goethem
Katrien Vanderheyden
Fleur Demuynck
Tim Lammens
Hetty Helsmoortel
Joëlle Vermeulen
Rosa Noguera
Ana P. Berbegall
et al.
A1
Artikel in een tijdschrift
in
JCI INSIGHT
2018
Circulating microRNA biomarkers for metastatic neuroblastoma
Fjoralba Zeka
Alan Van Goethem
Tim Lammens
Anneleen Decock
Hetty Helsmoortel
Genevieve Laureys
Michael Hogarty
Eveline Barbieri
Jason Shohet
Frank Berthold
et al.
C3
Conferentie
2018
Current understanding and future research priorities in malignancy associated with inborn errors of immunity and DNA repair disorders : the perspective of an interdisciplinary working group
Simon Bomken
Jutte van der Werff Ten Bosch
Andishe Attarbaschi
Chris M. Bacon
Arndt Borkhardt
Kaan Boztug
Ute Fischer
Fabian Hauck
Roland P. Kuiper
Tim Lammens
et al.
A1
Artikel in een tijdschrift
in
FRONTIERS IN IMMUNOLOGY
2018
Event-free survival of infants and toddlers enrolled in the HR-NBL-1/SIOPEN trial is associated with the level of neuroblastoma mRNAs at diagnosis
Maria V Corrias
Stefano Parodi
Andrei Tchirkov
Tim Lammens
Ales Vicha
Claudia Pasqualini
Catarina Träger
Yania Yáñez
Sandro Dallorso
Luigi Varesio
et al.
A1
Artikel in een tijdschrift
in
PEDIATRIC BLOOD & CANCER
2018
Exploring the long non-coding RNA landscape in juvenile myelomonocytic leukemia
Mattias Hofmans
Tim Lammens
S Bresolin
H Cavé
C Flotho
H Hasle
Hetty Helsmoortel
M Van den Heuvel-Eibrink
C Niemeyer
J Stary
et al.
C3
Conferentie
2018
Genes at the crossroad of primary immunodeficiencies and cancer
Charlotte Derpoorter
Maria Bordon Cueto De Braem
Genevieve Laureys
Filomeen Haerynck
Tim Lammens
A1
Artikel in een tijdschrift
in
FRONTIERS IN IMMUNOLOGY
2018
Leukaemic stem cell load at diagnosis predicts the development of relapse in young acute myeloid leukaemia patients
Diana Hanekamp
Barbara Denys
Gertjan JL Kaspers
Jeroen G te Marvelde
Gerrit Jan Schuurhuis
Valerie De Haas
Barbara De Moerloose
Eveline S de Bont
C Michel Zwaan
Anja de Jong
et al.
A1
Artikel in een tijdschrift
in
BRITISH JOURNAL OF HAEMATOLOGY
2018
Non-invasive differential diagnosis of neuroblastoma with other paediatric solid tumors using methylation profiling of circulating cell-free DNA
Ruben Van Paemel
Anneleen Decock
Charlotte Vandeputte
Tim Lammens
Genevieve Laureys
Franki Speleman
Wim Van Criekinge
Nadine Van Roy
Jo Vandesompele
Katleen De Preter
et al.
C3
Conferentie
2018
Non-invasive differential diagnosis of neuroblastoma with other paediatric solid tumors using methylation profiling of circulating cell-free DNA
Ruben Van Paemel
Anneleen Decock
Charlotte Vandeputte
Tim Lammens
Genevieve Laureys
Franki Speleman
Wim Van Criekinge
Nadine Van Roy
Jo Vandesompele
Katleen De Preter
et al.
C3
Conferentie
2018
Non-invasive differential diagnosis of neuroblastoma with other paediatric solid tumors using methylation profiling of circulating cell-free DNA
Ruben Van Paemel
Anneleen Decock
Charlotte Vandeputte
Tim Lammens
Genevieve Laureys
Franki Speleman
Wim Van Criekinge
Nadine Van Roy
Jo Vandesompele
Katleen De Preter
et al.
C3
Conferentie
2018
Pre-clinical evaluation of second generation PIM inhibitors for the treatment of T-cell acute lymphoblastic leukemia and lymphoma
Renate De Smedt
Sofie Peirs
Julie Morscio
Filip Matthijssens
Juliette Roels
Lindy Reunes
Béatrice Lintermans
Steven Goossens
Tim Lammens
Nadine Van Roy
et al.
A1
Artikel in een tijdschrift
in
HAEMATOLOGICA
2018
Predisposing mutations in hippo signaling reveal an actionable target in Burkitt lymphoma
Charlotte Derpoorter
Katrien Vandemeulebroecke
Tieneke Bauters
Jan Philippé
Genevieve Laureys
Tim Lammens
C3
Conferentie
2018
Recurrently affected genes in juvenile myelomonocytic leukaemia
Julia C Obenauer
Francois G Kavelaars
Mathijs A Sanders
Andrica CH de Vries
Valerie de Haas
H Berna Beverloo
Barbara De Moerloose
Tim Lammens
Michael Dworzak
Remco M Hoogenboezem
et al.
A1
Artikel in een tijdschrift
in
BRITISH JOURNAL OF HAEMATOLOGY
2018
Retrospective study of infant leukaemia in the University Hospitals of Leuven and Ghent
Barbara De Moerloose
E Nauwynck
K Arts
Leen Willems
V Labarque
Tim Lammens
A Uyttebroeck
A2
Artikel in een tijdschrift
in
BELGIAN JOURNAL OF HEMATOLOGY
2018
The genetic basis and cell of origin of mixed phenotype acute leukaemia
Thomas B. Alexander
Zhaohui Gu
Ilaria Iacobucci
Kirsten Dickerson
John K. Choi
Beisi Xu
Debbie Payne-Turner
Hiroki Yoshihara
Mignon L. Loh
John Horan
et al.
A1
Artikel in een tijdschrift
in
NATURE
2018
The long non-coding RNA landscape in juvenile myelomonocytic leukemia
Mattias Hofmans
Tim Lammens
Hetty Helsmoortel
Silvia Bresolin
Hélène Cavé
Christian Flotho
Henrik Hasle
Marry M van den Heuvel-Eibrink
Charlotte Niemeyer
Jan Stary
et al.
A1
Artikel in een tijdschrift
in
HAEMATOLOGICA
2018
The potential of methylome sequencing in the diagnostic work : up of pediatric solid tumors
Ruben Van Paemel
Charlotte Vandeputte
Bram De Wilde
Katleen De Preter
Nadine Van Roy
Jo Vandesompele
Tim Lammens
Wim Van Criekinge
P. Ultz
Nico Callewaert
et al.
C3
Conferentie
2018
2017
Digital multiplex ligation-dependent probe amplification for detection of key copy number alterations in T- and B-cell lymphoblastic leukemia
Anne Benard-Slagter
Ilse Zondervan
Karel de Groot
Farzaneh Ghazavi
Virinder Sarhadi
Pieter Van Vlierberghe
Barbara De Moerloose
Claire Schwab
Kim Vettenranta
Christine J Harrison
et al.
A1
Artikel in een tijdschrift
in
JOURNAL OF MOLECULAR DIAGNOSTICS
2017
Exome sequencing to identify novel neuroblastoma predisposition genes
Charlotte Derpoorter
Karl Vandepoele
Araceli Diez Fraile
Katrien Vandemeulebroecke
Nadine Van Roy
Bram De Wilde
Tim Lammens
Genevieve Laureys
C3
Conferentie
2017
Genetic insights in ETV6/RUNX1-positive B-cell precursor acute lymphoblastic leukaemia
Farzaneh Ghazavi
Tim Lammens
Pieter Van Vlierberghe
Barbara De Moerloose
A2
Artikel in een tijdschrift
in
BELGIAN JOURNAL OF HEMATOLOGY
2017
Identification of genetic aberrations predisposing to familial Burkitt lymphoma using whole genome sequencing
Ruben Van Paemel
Charlotte Derpoorter
Rein Demuynck
Eva Terras
Bram De Wilde
Tim Lammens
Genevieve Laureys
C3
Conferentie
2017
Long non-coding RNAs in leukemia : biology and clinical impact
Tim Lammens
Kaat Durinck
Annelynn Wallaert
Franki Speleman
Pieter Van Vlierberghe
A1
Artikel in een tijdschrift
in
CURRENT OPINION IN HEMATOLOGY
2017
Novel molecular genetic insights in paediatric B-cell precursor acute lymphoblastic leukaemia
Farzaneh Ghazavi
Tim Lammens
Pieter Van Vlierberghe
Barbara De Moerloose
A2
Artikel in een tijdschrift
in
BELGIAN JOURNAL OF HEMATOLOGY
2017
Shallow whole genome sequencing on circulating cell-free DNA allows reliable non-invasive copy number profiling in neuroblastoma patients
Nadine Van Roy
Malaïka Van der Linden
Pauline Depuydt
Björn Menten
Annelies Dheedene
Charlotte Vandeputte
Jo Van Dorpe
Genevieve Laureys
Marjolijn Renard
Tom Sante
et al.
C3
Conferentie
2017
Shallow whole genome sequencing on circulating cell-free DNA allows reliable noninvasive copy-number profiling in neuroblastoma patients
Nadine Van Roy
Malaïka Van der Linden
Björn Menten
Annelies Dheedene
Charlotte Vandeputte
Jo Van Dorpe
Genevieve Laureys
Marleen Renard
Tom Sante
Tim Lammens
et al.
A1
Artikel in een tijdschrift
in
CLINICAL CANCER RESEARCH
2017
Unravelling the biology of juvenile myelomonocytic leukaemia using transcriptomics
Hetty Helsmoortel
Tim Lammens
Pieter Van Vlierberghe
Barbara De Moerloose
A2
Artikel in een tijdschrift
in
BELGIAN JOURNAL OF HEMATOLOGY
2017
2016
A novel multiplex NGS-based digital MLPA assay for copy number detection of 700 target sequences in childhood acute lymphoblastic leukemia
Anne Benard
Ilse Zondervan
Jan Schouten
Karel de Groot
Farzaneh Ghazavi
Virinder Sarhadi
Pieter Van Vlierberghe
Barbara De Moerloose
Christine Harrison
Claire Schwab
et al.
C3
Conferentie
2016
Digital MLPA(TM) for copy number detection in childhood acute lymphoblasic leukemia : a novel multiplex NGS-based assay
A Benard
Barbara De Moerloose
I Zondervan
Farzaneh Ghazavi
V Sarhadi
Pieter Van Vlierberghe
Tim Lammens
S Knuutila
S Savola
C3
Conferentie
2016
Genetic characterization and therapeutic targeting of MYC translocated pediatric T-cell acute lymphoblastic leukemia
Gloria Milani
Kaat Durinck
Filip Matthijssens
Sofie Peirs
Tim Pieters
Lindy Reunes
Béatrice Lintermans
Niels Vandamme
Tim Lammens
Yunlei Li
et al.
C3
Conferentie
2016
Genomic landscape of pediatric mixed phenotype acute leukemia
Thomas B Alexander
Zhaohui Gu
John K Choi
Mignon Loh
John Horan
Barbara Buldini
Giuseppe Basso
Sarah Elitzur
Valerie de Haas
C Michel Zwaan
et al.
C3
Conferentie
2016
Identification of candidate oncogenes and chromosomal breakpoint sequencing by targeted locus amplification in T-cell acute lymphoblastic leukemia
Eric Vroegindeweij
Tim Lammens
Kirsten Cante-Barrett
Erik Splinter
A Uyttebroeck
Jessica GC Buijs-Gladdines
Wilco Smits
Peter Vandenberghe
Renate De Smedt
Barbara De Moerloose
et al.
C3
Conferentie
2016
Leukemia in infants : a retrospective study (1992-2014) in the Ghent University Hospital
Elise Nauwynck
Tim Lammens
Vincent Vakaet
N Van Damme
Yves Benoit
Veerle Mondelaers
Els Vandecruys
Genevieve Laureys
L Vakaet
Barbara De Moerloose
C3
Conferentie
2016
LIN28B is over-expressed in specific subtypes of pediatric leukemia and regulates lncRNA H19
Hetty Helsmoortel
Barbara De Moerloose
Tim Pieters
Farzaneh Ghazavi
Silvia Bresolin
Helene Cave
Andrica de Vries
Valerie de Haas
Christian Flotho
Veerle Labarque
et al.
A1
Artikel in een tijdschrift
in
HAEMATOLOGICA
2016
LIN28B is overexpressed in pediatric leukemia and regulates LNCRNA H19
Hetty Helsmoortel
Barbara De Moerloose
Silvia Bresolin
Hélèe Cavé
Christian Flotho
Charlotte Niemeyer
Jan Stary
Marry van den Heuvel-Eibrink
Pieter Van Vlierberghe
Tim Lammens
C3
Conferentie
2016
LIN28B overexpression defines a novel fetal-like subgroup of juvenile myelomonocytic leukemia
Hetty Helsmoortel
Silvia Bresolin
Tim Lammens
Hélène Cavé
Peter Noellke
Aurélie Caye
Farzaneh Ghazavi
Andrica de Vries
Henrik Hasle
Veerle Labarque
et al.
A1
Artikel in een tijdschrift
in
BLOOD
2016
Novel molecular genetic insights in pediatric B-cell precursor acute lymphoblastic leukemia
Farzaneh Ghazavi
Barbara De Moerloose
Pieter Van Vlierberghe
Tim Lammens
Proefschrift
2016
RPPA-Based protein profiling reveals enhanced PI3K/AKT/mTOR signaling in ETV6/RUNX1-positive acute lymphoblastic leukemia patients with low CD200 expression
Farzaneh Ghazavi
Valentina Serafin
Pieter Rondou
Tim Lammens
Franki Speleman
Benedetta Accordi
Barbara De Moerloose
Pieter Van Vlierberghe
C3
Conferentie
2016
Unique long non-coding RNA expression signature in ETV6/RUNX1-Driven B-cell precursor acute lymphoblastic leukemia
Farzaneh Ghazavi
Barbara De Moerloose
Wouter Van Loocke
Annelynn Wallaert
Alina Ferster
Marleen Bakkus
Geneviève Plat
Eric Delabesse
Anne Uyttebroeck
Filip Van Nieuwerburgh
et al.
C3
Conferentie
2016
Unique long non-coding RNA expression signature in ETV6/RUNX1-driven B-cell precursor acute lymphoblastic leukemia
Farzaneh Ghazavi
Barbara De Moerloose
Wouter Van Loocke
Annelynn Wallaert
Hetty Helsmoortel
Alina Ferster
Marleen Bakkus
Geneviève Plat
Eric Delabesse
Anne Uyttebroeck
et al.
A1
Artikel in een tijdschrift
in
ONCOTARGET
2016
Unraveling the biology of juvenile myelomonocytic leukemia using transcriptomics
Hetty Helsmoortel
Barbara De Moerloose
Tim Lammens
Pieter Van Vlierberghe
Proefschrift
2016
2015
CD200/BTLA deletions in pediatric precursor B-cell acute lymphoblastic leukemia treated according to the EORTC-CLG 58951 protocol
Farzaneh Ghazavi
Emmanuelle Clappier
Tim Lammens
Stefan Suciu
Aurélie Caye
Samira Zegrari
Marleen Bakkus
Nathalie Grardel
Yves Benoit
Odile Minckes
et al.
A1
Artikel in een tijdschrift
in
HAEMATOLOGICA
2015
Excellent outcome in pediatric AML with response guided chemotherapy without allogeneic HSCT in first complete remission results from prococol DB-AML01
Eveline de Bont
Ardine Reedijk
Tim Lammens
Valerie de Haas
Barbara Denys
Laurence Dedeken
Marry van den Heuvel
Maroeska te Loo
Anne Uyttebroeck
An Vandamme
et al.
C3
Conferentie
2015
MicroRNA-193b-3p acts as a tumor suppressor by targeting the MYB oncogene in T-cell acute lymphoblastic leukemia
Evelien Mets
Joni Van der Meulen
Gert Van Peer
Michael Boice
Pieter Mestdagh
Inge Van de Walle
Tim Lammens
Steven Goossens
Barbara De Moerloose
Yves Benoit
et al.
A1
Artikel in een tijdschrift
in
LEUKEMIA
2015
Molecular basis and clinical significance of genetic aberrations in B-cell precursor acute lymphoblastic leukemia
Farzaneh Ghazavi
Tim Lammens
Nadine Van Roy
Bruce Poppe
Franki Speleman
Yves Benoit
Pieter Van Vlierberghe
Barbara De Moerloose
A1
Artikel in een tijdschrift
in
EXPERIMENTAL HEMATOLOGY
2015
Mutational spectrum of juvenile myelomonocytic leukemia
J Obenauer
F Kavelaars
ACH de Vries
M Sanders
V de Haas
Barbara De Moerloose
Tim Lammens
M Dworzak
C Niemeyer
P Valk
et al.
C3
Conferentie
2015
Novel biological insights in T-cell acute lymphoblastic leukemia
Kaat Durinck
Steven Goossens
Sofie Peirs
Annelynn Wallaert
Wouter Van Loocke
Filip Matthijssens
Tim Pieters
Gloria Milani
Tim Lammens
Pieter Rondou
et al.
A1
Artikel in een tijdschrift
in
EXPERIMENTAL HEMATOLOGY
2015
The H3K27me3 demethylase UTX is a gender-specific tumor suppressor in T-cell acute lymphoblastic leukemia
Joni Van der Meulen
Viraj Sanghvi
Konstantinos Mavrakis
Kaat Durinck
Fang Fang
Filip Matthijssens
Pieter Rondou
Monica Rosen
Tim Pieters
Peter Vandenberghe
et al.
A1
Artikel in een tijdschrift
in
BLOOD
2015
The long non-coding RNA H19 is regulated by LIN28B
Hetty Helsmoortel
Barbara De Moerloose
Tim Pieters
Farzaneh Ghazavi
S Bresolin
H Cavé
A Caye
ACH de Vries
C Flotho
V Labarque
et al.
C3
Conferentie
2015
2014
ABT-199 mediated inhibition of BCL-2 as a novel therapeutic strategy in early immature T-cell acute lymphoblastic leukemia
Sofie Peirs
Filip Matthijssens
Steven Goossens
Kirsten Canté-Barrett
Tim Lammens
Barbara De Moerloose
Yves Benoit
Jean Soulier
Bruce Poppe
Tom Taghon
et al.
C3
Conferentie
2014
ABT-199 mediated inhibition of BCL-2 as a novel therapeutic strategy in T-cell acute lymphoblastic leukemia
Sofie Peirs
Filip Matthijssens
Steven Goossens
Inge Van de Walle
Katia Ruggero
Charles E de Bock
Sandrine Degryse
Kirsten Canté-Barrett
Delphine Briot
Emmanuelle Clappier
et al.
A1
Artikel in een tijdschrift
in
BLOOD
2014
ABT-199 mediated inhibition of BCL2 as a novel therapeutic strategy in T-cell acute lymphoblastic leukemia
Sofie Peirs
Filip Matthijssens
Steven Goossens
Charles De Bock
Kirsten Canté-Barrett
Tim Lammens
Inge Van de Walle
Barbara De Moerloose
Yves Benoit
Bruce Poppe
et al.
C3
Conferentie
2014
Acute lymphoblastic leukemia in children with Down syndrome: a retrospective analysis from the Ponte di Legno study group
Trudy D Buitenkamp
Shai Izraeli
Martin Zimmermann
Erik Forestier
Nyla A Heerema
Marry M van den Heuvel-Eibrink
Rob Pieters
Carin M Korbijn
Lewis B Silverman
Kjeld Schmiegelow
et al.
A1
Artikel in een tijdschrift
in
BLOOD
2014
Age-associated differential microRNA levels in human follicular fluid reveal pathways potentially determining fertility and success of in vitro fertilization
Araceli Diez Fraile
Tim Lammens
Kelly Tilleman
Wojciech Witkowski
Bruno Verhasselt
Petra De Sutter
Yves Benoit
Marc Espeel
Katharina D'Herde
A1
Artikel in een tijdschrift
in
HUMAN FERTILITY
2014
Juvenile myelomonocytic leukaemia: the quest for more specific therapies
Hetty Helsmoortel
Tim Lammens
Nadine Van Roy
Jan Philippé
Pascale De Paepe
Yves Benoit
Franki Speleman
Pieter Van Vlierberghe
Barbara De Moerloose
A2
Artikel in een tijdschrift
in
BELGIAN JOURNAL OF HEMATOLOGY
2014
LIN28B defines an aggressive subtype of juvenile myelomonocytic leukemia
Hetty Helsmoortel
Tim Lammens
Farzaneh Ghazavi
Aurelie Caye
Hélène Cavé
Christian Flotho
Charlotte Niemeyer
Jan Stary
Silvia Bresolin
Riccardo Masetti
et al.
C3
Conferentie
2014
Mind the gap : translation of genetic research into clinical care in the context of RUNX1-associated leukaemia predisposition
Tim Ripperger
Alina Ferster
Tim Lammens
Barbara De Moerloose
Laurence Rozen
Nadira Azzi
Charlotte M Niemeyer
Brigitte Schlegelberger
Doris Steinemann
C3
Conferentie
2014
Prognostic relevance of BTLA/CD200 deletion in pediatric pre-B cell acute lymphoblastic leukemia
Farzaneh Ghazavi
Tim Lammens
Stefan Suciu
Marleen Bakkus
Hélène Cavé
Franki Speleman
Yves Benoit
Barbara De Moerloose
Pieter Van Vlierberghe
C3
Conferentie
2014
Prognostic relevance of CD200/BTLA deletions in pediatric precursor-B cell acute lymphoblastic leukemia treated according to the EORTD-CLG 58951 protocol
Farzaneh Ghazavi
Tim Lammens
Emmanuelle Clappier
Stefan Suciu
Aurélie Caye
Samira Zegrari
Marleen Bakkus
Nathalie Grardel
Yves Benoit
Yves Bertrand
et al.
C3
Conferentie
2014
The ASH1-RELATED3 SET-domain protein controls cell division competence of the meristem and the quiescent center of the Arabidopsis primary root
Robert Kumpf
Tage Thorstensen
Mohummad Aminur Rahman
Jefri Heyman
H Zeynep Nenseth
Tim Lammens
Ullrich Herrmann
Ranjan Swarup
Silje Veie Veiseth
Gitika Emberland
et al.
A1
Artikel in een tijdschrift
in
PLANT PHYSIOLOGY
2014
2013
Delayed elemination of methotrexate by cola beverages in a pediatric acute lymphoblastic leukemia population
Tieneke Bauters
Tim Lammens
Pauline Belin
Yves Benoit
Hugo Robays
Barbara De Moerloose
A1
Artikel in een tijdschrift
in
LEUKEMIA & LYMPHOMA
2013
Long non-coding RNAs in pluripotent stem cell biology
Tim Lammens
INGE D'HONT
Katharina D'Herde
Yves Benoit
Araceli Diez Fraile
A1
Artikel in een tijdschrift
in
VETERINARY QUARTERLY
2013
miRNAs distinguish children with myelodysplastic syndrome from healthy donors
Hetty Helsmoortel
Tim Lammens
Pieter Mestdagh
Nadine Van Roy
Anne Uyttebroeck
Alina Ferster
Yves Benoit
Jo Vandesompele
Franki Speleman
Pieter Van Vlierberghe
et al.
C3
Conferentie
2013
miRNAs distinguish children with myelodysplastic syndrome from healthy donors
Hetty Helsmoortel
Tim Lammens
Pieter Mestdagh
Nadine Van Roy
Anne Uyttebroeck
Alina Ferster
Yves Benoit
Jo Vandesompele
Franki Speleman
Pieter Van Vlierberghe
et al.
C3
Conferentie
2013
The calcium-sensing receptor as a regulator of cellular fate in normal and pathological conditions
Araceli Diez Fraile
Tim Lammens
Yves Benoit
Katharina D'Herde
A1
Artikel in een tijdschrift
in
CURRENT MOLECULAR MEDICINE
2013
The need for transparency and good practices in the qPCR literature
Stephen A Bustin
Vladimir Benes
Jeremy Garson
Jan Hellemans
Jim Huggett
Mikael Kubista
Reinhold Mueller
Tania Nolan
Michael W Pfaffl
Gregory Shipley
et al.
A1
Artikel in een tijdschrift
in
NATURE METHODS
2013
2012
Improved risk stratification and outcome prediction in children with average risk 1 precursor-B acute lymphoblastic leukemia using a 19-microRNA signature
Farzaneh Ghazavi
Tim Lammens
Stefan Suciu
Genevieve Laureys
Marleen Bakkus
Alina Ferster
Anne Uyttebroeck
Patrick Lutz
Hélène Cavé
Geneviève Plat
et al.
C3
Conferentie
2012
Improved risk-stratification and outcome prediction in children with average risk precursor-B acute lymphoblastic leukemia using a 19-microRNA signature
Farzaneh Ghazavi
Tim Lammens
Stefan Suciu
Genevieve Laureys
Marleen Bakkus
Alina Ferster
Anne Uyttebroeck
Patrick Lutz
Hélène Cavé
Geneviève Plat
et al.
C3
Conferentie
2012
Isolation of disseminated neuroblastoma cells from bone marrow aspirates for pretreatment risk assessment by array comparative genomic hybridization
Mado Vandewoestyne
Candy Kumps
Katrien Swerts
Björn Menten
Tim Lammens
Jan Philippé
Katleen De Preter
Genevieve Laureys
Nadine Van Roy
Franki Speleman
et al.
A1
Artikel in een tijdschrift
in
INTERNATIONAL JOURNAL OF CANCER
2012
N-Cadherin in neuroblastoma disease : expression and clinical significance
Tim Lammens
Katrien Swerts
Lara Derycke
ANNEMIE DE CRAEMER
Sara De Brouwer
Katleen De Preter
Nadine Van Roy
Jo Vandesompele
Franki Speleman
Jan Philippé
et al.
A1
Artikel in een tijdschrift
in
PLOS ONE
2012
Study of the miRNome of childhood myelodysplastic syndrome
Hetty Helsmoortel
Tim Lammens
Nadine Van Roy
Anne Uyttebroeck
Alina Ferster
Yves Benoit
Franki Speleman
Barbara De Moerloose
C3
Conferentie
2012
2011
Atypical E2F activity coordinates PHR1 photolyase gene transcription with endoreduplication onset
Amandine Radziejwoski
Kobe Vlieghe
Tim Lammens
Barbara Berckmans
Sara Maes
Marcel AK Jansen
Claudia Knappe
Andreas Albert
Harald K Seidlitz
Günther Bahnweg
et al.
A1
Artikel in een tijdschrift
in
EMBO JOURNAL
2011
Light-dependent regulation of DEL1 is determined by the antagonistic action of E2Fb and E2Fc
Barbara Berckmans
Tim Lammens
Hilde Van Den Daele
Zoltan Magyar
Laszlo Bögre
Lieven De Veylder
A1
Artikel in een tijdschrift
in
PLANT PHYSIOLOGY
2011
MicroRNA-based diagnosis, prognosis and treatment of paediatric acute lymphoblastic leukaemia
Tim Lammens
Farzaneh Ghazavi
Franki Speleman
Yves Benoit
Barbara De Moerloose
A2
Artikel in een tijdschrift
in
BELGIAN JOURNAL OF HEMATOLOGY
2011
2010
Microrna expression in pediatric precursor-B acute lymphoblastic leukemia: biology, classification and prognosis
Tim Lammens
Barbara De Moerloose
Jonas Van Baelen
Joni Van der Meulen
Pieter Mestdagh
Bruno Verhasselt
Jan Philippé
Franki Speleman
Yves Benoit
C3
Conferentie
2010
The MCM-Binding Protein ETG1 Aids Sister Chromatid Cohesion Required for Postreplicative Homologous Recombination Repair
Naoki Takahashi
Mauricio Quimbaya Gomez
Veit Schubert
Tim Lammens
Klaas Vandepoele
Ingo Schubert
Minami Matsui
Dirk Inzé
Geert Berx
Lieven De Veylder
A1
Artikel in een tijdschrift
in
PLOS GENETICS
2010
2009
APC/C-CCS52A complexes control meristem maintenance in the Arabidopsis root
Marleen Vanstraelen
Mikhail Baloban
Olivier Da Ines
Antonietta Cultrone
Tim Lammens
Véronique Boudolf
Spencer Brown
Lieven De Veylder
Peter Mergaert
Eva Kondorosi
A1
Artikel in een tijdschrift
in
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
2009
Apoptotic, necrotic and autophagic cell death types in pathophysiological conditions: morphological and histological aspects
Araceli Diez Fraile
Tim Lammens
Katharina D'Herde
Hoofdstuk in een boek
in
Phagocytosis of dying cells : from molecular mechanisms to human disease
2009
Atypical E2Fs: new players in the E2F transcription factor family
Tim Lammens
Jing Li
Gustavo Leone
Lieven De Veylder
A1
Artikel in een tijdschrift
in
Trends in Cell Biology
2009
CDKB1;1 forms a functional complex with CYCA2;3 to suppress endocycle onset
Véronique Boudolf
Tim Lammens
Joanna Boruc
Jelle Van Leene
Hilde Van Den Daele
Sara Maes
Gert Van Isterdael
Eugenia Russinova
Eva Kondorosi
Erwin Witters
et al.
A1
Artikel in een tijdschrift
in
Plant Physiology
2009
Molecular control of endoreduplication in Arabidopsis thaliana
Tim Lammens
Dirk Inzé
Lieven De Veylder
Proefschrift
2009
Quantitative RNA expression analysis with Affymetrix Tiling 1.0R arrays identifies new E2F target genes
Naïra Naouar
Klaas Vandepoele
Tim Lammens
Tineke Casneuf
Georg Zeller
Paul Van Hummelen
Detlef Weigel
Gunnar Rätsch
Dirk Inzé
Martin Kuiper
et al.
A1
Artikel in een tijdschrift
in
Plant Journal
2009
2008
Atypical E2F activity restrains APC/C-CCS52A2 function obligatory for endocycle onset
Tim Lammens
Véronique Boudolf
Leila Kheibarshekan Asl
L Panagiotis Zalmas
Tarik Gaamouche
Sara Maes
Marleen Vanstraelen
Eva Kondorosi
Nicholas B La Thangue
Willy Govaerts
et al.
A1
Artikel in een tijdschrift
in
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
2008
The DNA replication checkpoint aids survival of plants deficient in the novel replisome factor ETG1
Naoki Takahashi
Tim Lammens
Véronique Boudolf
Sara Maes
Takeshi Yoshizumi
Geert De Jaeger
Erwin Witters
Dirk Inzé
Lieven De Veylder
A1
Artikel in een tijdschrift
in
EMBO JOURNAL
2008