Research Explorer

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Researcher

Tim Lammens

Awards & Distinctions

157 Results

2024

A 69 long non-coding RNAs expression signature predicts relapse and acts as an independent prognostic factor in pediatric acute myeloid leukemia

Zhiyao RenJolien VanhoorenCharlotte DerpoorterBarbara De MoerlooseTim Lammens

A 69 long noncoding RNA signature predicts relapse and acts as independent prognostic factor in pediatric AML

Zhiyao RenJolien VanhoorenCharlotte DerpoorterBarbara De MoerlooseTim Lammens

A1 Journal Article in BLOOD ADVANCES

Long non-coding RNAs in neuroblastoma : pathogenesis, biomarkers and therapeutic targets

Niels VercouillieZhiyao RenEVA TERRASTim Lammens

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

PDXGhent : patient derived tumor xenografting mouse Core Facility Ghent

Liselot MusSteven GoossensTim LammensLindsey DevisscherPanagiotis NtziachristosOlivier De WeverFrédéric Clement

PDXGhent : patient derived tumor xenografting mouse core facility Ghent

Liselot MusSteven GoossensTim LammensLindsey DevisscherPanagiotis NtziachristosOlivier De WeverFrédéric Clement

Targeting hyperactive platelet-derived growth factor receptor-β signaling in T-cell acute lymphoblastic leukemia and lymphoma

Stien De ConinckRenate De SmedtBéatrice LintermansLindy ReunesHansen J. KosasihAlexandra ReekmansLauren M. BrownNadine Van RoyBruno PalhaisJuliette Roels et al.

A1 Journal Article in HAEMATOLOGICA

2023

A 46 long non-coding RNAs expression signature accurately predicts relapse and acts as an independent prognostic factor in pediatric acute myeloid leukemia

Zhiyao RenJolien VanhoorenCharlotte DerpoorterBarbara De MoerlooseTim Lammens

CAR-T in the treatment of acute myeloid leukemia : barriers and how to overcome them

Jolien VanhoorenRani DobbelaereCharlotte DerpoorterLarissa DenewethLaurens Van CampAnne UyttebroeckBarbara De MoerlooseTim Lammens

A1 Journal Article in HEMASPHERE

Childhood cancer predisposition : exploring mising heritability using DNA sequencing approaches

Charlotte DerpoorterTim LammensGenevieve Laureys

Drug response profiling informs personalized bridging to cell therapy for patients with relapsed/refractory acute lymphoblastic leukemia

Fabio D. SteffenAndrej LissatJulia AltenCornelia EckertBodmer NicoleThorhauge Als-Nielsen Bodil E.Adriana BalduzziSarah ElitzurAndras KristonGergely Nyiri et al.

European standard clinical practice : key issues for the medical care of individuals with familial leukemia

Alisa FörsterClaudia DavenportNicolas DuployezMiriam ErlacherAlina FersterJude FitzgibbonGudrun GöhringHenrik HasleMarjolijn C. JongmansAlexandra Kolenova et al.

A1 Journal Article in EUROPEAN JOURNAL OF MEDICAL GENETICS

In vivo stabilization of a less toxic asparaginase variant leads to a durable antitumor response in acute leukemia

Maaike Van TrimpontAmanda M. SchalkYanti De VisserHien Anh NguyenLindy ReunesKatrien VandemeulebroeckeEvelien PeetersYing SuHyun LeePhilip L. Lorenzi et al.

A1 Journal Article in HAEMATOLOGICA

TEARDRoP : Team EARly DRug development in Paediatric oncology

Liselot MusBram De WildeTim Lammens

Whole genome sequencing and inheritance-based variant filtering as a tool for unraveling missing heritability in pediatric cancer

Charlotte DerpoorterRuben Van PaemelKatrien VandemeulebroeckeJolien VanhoorenBram De WildeGenevieve LaureysTim Lammens

A1 Journal Article in PEDIATRIC HEMATOLOGY AND ONCOLOGY

2022

A clinically annotated post-mortem approach to study multi-organ somatic mutational clonality in normal tissues

Tom LuijtsKerryn ElliottJoachim SiawJoris Van de VeldeElien BeylsArne ClaeysTim LammensErik LarssonWouter WillaertAnne Vral et al.

A1 Journal Article in SCIENTIFIC REPORTS

Correction to : functional classification of RUNX1 variants in familial platelet disorder with associated myeloid malignancies

Melanie DeckerTim LammensAlina FersterMiriam ErlacherAyami YoshimiCharlotte M. NiemeyerMartijn P. T. ErnstMarc H. G. P. RaaijmakersNicolas DuployezAndreas Flaum et al.

Deciphering the non-coding RNA landscape of pediatric acute myeloid leukemia

Jolien VanhoorenLaurens Van CampBarbara DepreterMartijn de JongAnne UyttebroeckAn Van Van DammeLaurence DedekenMarie-Françoise DresseJutte van der Werff ten BoschMattias Hofmans et al.

A1 Journal Article in CANCERS

Deciphering the non-coding landscape of pediatric acute myeloid leukemia

Jolien VanhoorenLaurens Van CampBarbara DepreterMartijn de JongAnne UyttebroeckAn Van DammeLaurence DedekenMarie-Françoise DresseJutte van der Werff ten BoschMattias Hofmans et al.

Deciphering the non-coding landscape of pediatric acute myeloid leukemia

Laurens Van CampJolien VanhoorenBarbara DepreterMartijn de JongAnne UyttebroeckAn Van DammeLaurence DedekenMarie-Françoise DresseJutte van der Werff ten BoschMattias Hofmans et al.

Evaluation of PEG-L-asparaginase in asparagine suppression and anti-drug antibody development in healthy Beagle dogs : a multi-phase preclinical study

L.R. FeenstraR. GehringI.M. van GeijswijkT. KönigH.C.M.T PrinsenKatrien VandemeulebroeckeTim LammensAdriana KrupaE. Teske

A1 Journal Article in VETERINARY JOURNAL

Mutational permutations of a single amino acid exert divergent phenotypic effects in human, mice and cellular models of SAMD9L bone marrow failure disorder

Sushree S SahooCharnise Goodings-HarrisShondra MillerMaria Angeles Lillo OsunaBaranda S HansenLei HanTi-Cheng ChangTim LammensMattias HofmansMarta Derecka et al.

Novel insights on the use of L-asparaginase as an efficient and safe anti-cancer therapy

Maaike Van TrimpontEvelien PeetersYanti De VisserAmanda M. SchalkVeerle MondelaersBarbara De MoerlooseArnon LavieTim LammensSteven GoossensPieter Van Vlierberghe

A1 Journal Article in CANCERS

Optimization of asparaginase therapy in childhood acute lymphoblastic leukemia

Veerle MondelaersBarbara De MoerlooseTim Lammens

Practice guidelines for the therapeutic drug monitoring of asparaginase in acute lymphoblastic leukemia

Veerle MondelaersTim LammensMartijn de JongLarissa DenewethKatrien VandemeulebroeckeBarbara De Moerloose

A2 Journal Article in BELGIAN JOURNAL OF HEMATOLOGY

Predicting outcomes with circulating adrenergic neuroblastoma mRNAs in children with relapsed and refractory neuroblastoma : a BEACON-Neuroblastoma biomarker study

Lucas MorenoRebekah WestonVirginie VipreyAndrei TchirkovMaria CorriasTim LammensJuliet GrayCormac OwensJennifer LaidlerMarion Gambart et al.

Targeted therapy in juvenile myelomonocytic leukemia : where are we now?

Nele De VosMattias HofmansTim LammensBram De WildeNadine Van RoyBarbara De Moerloose

A1 Journal Article in PEDIATRIC BLOOD & CANCER

The feasibility of using liquid biopsies as a complementary assay for copy number aberration profiling in routinely collected paediatric cancer patient samples

Ruben Van PaemelCharlotte VandeputteLennart RamanJolien Van ThorreLeen WillemsJo Van DorpeMalaïka Van der LindenJilke De WildeAndries De KokerBjörn Menten et al.

A1 Journal Article in EUROPEAN JOURNAL OF CANCER

Tracking the molecular fingerprint of head and neck cancer for recurrence detection in liquid biopsies

Araceli Diez-FraileJoke De CeulaerCharlotte DerpoorterChristophe SpaasTom De BackerPhilippe LamoralJohan AbeloosTim Lammens

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

2021

CircRNAs dysregulated in juvenile myelomonocytic leukemia : CircMCTP1 stands out

Anna Dal MolinMattias HofmansEnrico GaffoAlessia BuratinHélène CavéChristian FlothoValerie de HaasCharlotte M. NiemeyerJan StaryPieter Van Vlierberghe et al.

A1 Journal Article in FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY

Circulating non-coding RNAs in head and neck cancer : roles in diagnosis, prognosis, and therapy monitoring

Araceli Diez-FraileJoke De CeulaerCharlotte DerpoorterChristophe SpaasTom De BackerPhilippe LamoralJohan AbeloosTim Lammens

A1 Journal Article in CELLS

Current developments and hurdles in CAR-T cell therapy for acute myeloid leukaemia

Laurens Van CampTim LammensAnne UyttebroeckBarbara De Moerloose

A2 Journal Article in BELGIAN JOURNAL OF HEMATOLOGY

Deciphering molecular heterogeneity in pediatric AML using a cancer vs. normal transcriptomic approach

Barbara DepreterBarbara De MoerlooseKarl VandepoeleAnne UyttebroeckAn Van DammeEva TerrasBarbara DenysLaurence DedekenMarie-Francoise DresseJutte Van der Werff Ten Bosch et al.

A1 Journal Article in PEDIATRIC RESEARCH

Favorable outcome of NUTM1-rearranged infant and pediatric B cell precursor acute lymphoblastic leukemia in a collaborative international study

Judith M. BoerMaria Grazia ValsecchiFemke M. HormannŽeljko AntićMarketa ZaliovaClaire SchwabGiovanni CazzanigaChloé ArfeuilleHélène CavéAndishe Attarbaschi et al.

A1 Journal Article in LEUKEMIA

Functional classification of RUNX1 variants in familial platelet disorder with associated myeloid malignancies

Melanie DeckerTim LammensAlina FersterMiriam ErlacherAyami YoshimiCharlotte M. NiemeyerMartijn P. T. ErnstMarc H. G. P. RaaijmakersNicolas DuployezAndreas Flaum et al.

A1 Journal Article in LEUKEMIA

Germline SAMD9L triple-allelic mosaicism with independent segregation into biallelic offsprings : molecular support for non-mendelian inheritance

S SahooC GoodingsM Angeles LilloTim LammensJ van der Werff ten BoschB StrahmBarbara De MoerlooseM Wlodarski

Long non-coding RNAs as novel therapeutic targets in juvenile myelomonocytic leukemia

Mattias HofmansTim LammensBarbara DepreterYing WuMiriam ErlacherAurélie CayeHélène CavéChristian FlothoValerie de HaasCharlotte M. Niemeyer et al.

A1 Journal Article in SCIENTIFIC REPORTS

Minimally invasive classification of pediatric solid tumors using reduced representation bisulfite sequencing of cell-free DNA : a proof-of-principle study

Ruben Van PaemelAndries De KokerCharlotte VandeputteLieke van ZogchelTim LammensGenevieve LaureysJo VandesompeleGudrun SchleiermacherMathieu ChicardNadine Van Roy et al.

A1 Journal Article in EPIGENETICS

Novel therapeutic targets in juvenile myelomonocytic leukaemia : are noncoding RNAs valuable treatment options?

Mattias HofmansTim LammensJan PhilippéBarbara De Moerloose

A2 Journal Article in BELGIAN JOURNAL OF HEMATOLOGY

Novel therapeutic targets in juvenile myelomonocytic leukemia : are noncoding RNAs valuable treatment options?

Mattias HofmansBarbara De MoerlooseJan PhilippéTim Lammens

RUNX2 regulates leukemic cell metabolism and chemotaxis in high-risk T cell acute lymphoblastic leukemia

Filip MatthijssensNitesh D. SharmaMonique NysusChristian K. NicklHuining KangDominique R. PerezBéatrice LintermansWouter Van LoockeJuliette RoelsSofie Peirs et al.

A1 Journal Article in JOURNAL OF CLINICAL INVESTIGATION

TARP as antigen in cancer immunotherapy

Jolien VanhoorenCharlotte DerpoorterBarbara DepreterLarissa DenewethJan PhilippéBarbara De MoerlooseTim Lammens

A1 Journal Article in CANCER IMMUNOLOGY IMMUNOTHERAPY

2020

Aging of preleukemic thymocytes drives CpG island hypermethylation in T-cell acute lymphoblastic leukemia

Juliette RoelsMorgan ThénozBronislawa SzarzynskaMattias LandforsStien De ConinckLisa DemoenLien ProvezAnna KuchmiySteven StrubbeLindy Reunes et al.

Aging of preleukemic thymocytes drives CpG island hypermethylation in T-cell acute lymphoblastic leukemia

Juliette RoelsMorgan ThénozB SzarzyńskaM LandforsStien De ConinckLisa DemoenLien ProvezAnna KuchmiySteven StrubbeLindy Reunes et al.

A2 Journal Article in BLOOD CANCER DISCOVERY

Clinical significance of TARP expression in pediatric acute myeloid leukemia

B. DepreterBarbara De MoerlooseKarl VandepoeleA. UyttebroeckA. Van DammeB. DenysL. DedekenM. -F. DresseJ. Van der Werff Ten BoschM. Hofmans et al.

Clinical significance of TARP expression in pediatric acute myeloid leukemia

Barbara DepreterBarbara De MoerlooseKarl VandepoeleAnne UyttebroeckAn Van DammeBarbara DenysLaurence DedekenMarie-Françoise DresseJutte Van Der Werff Ten BoschMattias Hofmans et al.

A1 Journal Article in HEMASPHERE

Exploring the molecular and phenotypical heterogeneity between patients with pediatric acute myeloid leukemia

Barbara DepreterTim LammensJan Philippé

In vitro characterization of hippo signaling in hematological childhood malignancies

Charlotte DerpoorterJolien VanhoorenLarissa DenewethKatrien VandemeulebroeckeGenevieve LaureysTim Lammens

Leukaemic stem cells in AML : where are we now? An update on recent findings and detection

Barbara DepreterBarbara De MoerlooseJan PhilippéTim Lammens

A2 Journal Article in BELGIAN JOURNAL OF HEMATOLOGY

Minimally invasive classification of pediatric solid tumors using reduced representation bisulfite sequencing of cell-free DNA

Ruben Van PaemelAndries De KokerCharlotte VandeputteLieke Van ZogchelTim LammensGenevieve LaureysJo VandesompeleGudrun SchleiermacherMatthieu ChicardNadine Van Roy et al.

NUTM1-rearranged infant and pediatric B cell precursor acute lymphoblastic leukemia : a good prognostic subtype identified in a collaborative international study

Judith M. BoerMaria Grazia ValsecchiFemke M. HormannZeljko AnticMarketa ZaliovaClaire SchwabGiovanni CazzanigaChloe ArfeuilleHelene CaveAndishe Attarbaschi et al.

Prospective, real-time monitoring of pegylated Escherichia coli and Erwinia asparaginase therapy in childhood acute lymphoblastic leukaemia and non-Hodgkin lymphoma in Belgium

Veerle MondelaersAlina FersterAnne UyttebroeckBenedicte BrichardJuttevan der Werff ten BoschKoenraad NorgaNadine FrancotteCaroline PietteKatrien VandemeulebroeckeCharlotte Verbeke et al.

A1 Journal Article in BRITISH JOURNAL OF HAEMATOLOGY

Retrospective analysis of the incidence and characteristics of paediatric myelodysplastic syndrome and juvenile myelomonocytic leukaemia in Belgium

Lindsey De SmaeleMattias HofmansTim LammensA Van DammeJutte van der Werff ten BoschA FersterJoris VerlooyC ChantrainJan PhilippéNadine Van Roy et al.

A2 Journal Article in BELGIAN JOURNAL OF HEMATOLOGY

TARP is an immunotherapeutic target in acute myeloid leukemia expressed in the leukemic stem cell compartment

Barbara DepreterKarin WeeningKarl VandepoeleMagnus EssandBarbara De MoerlooseMaria ThemeliJacqueline CloosDiana HanekampIne MoorsINGE D'HONT et al.

A1 Journal Article in HAEMATOLOGICA

Targeting cytokine- and therapy-induced PIM1 activation in preclinical models of T-cell acute lymphoblastic leukemia and lymphoma

Renate De SmedtJulie MorscioLindy ReunesJuliette RoelsValentina BardelliBéatrice LintermansWouter Van LoockeAfonso AlmeidaLaurence C. CheungRishi S. Kotecha et al.

A1 Journal Article in BLOOD

The EMT modulator SNAI1 contributes to AML pathogenesis via its interaction with LSD1

Catherine L. CarmichaelJueqiong WangThao NguyenOluseyi KolawoleAissa BenyoucefCharlotte De MazièreAnna MilneSona SamuelKevin Robert GillinderSoroor Hediyeh-zadeh et al.

A1 Journal Article in BLOOD

The altered transcriptome of pediatric myelodysplastic syndrome revealed by RNA sequencing

L ZubovicS PiazzaT TebaldiL CozzutoG PalazzoV SidarovichV De SanctisR BertorelliTim LammensMattias Hofmans et al.

A1 Journal Article in JOURNAL OF HEMATOLOGY & ONCOLOGY

The interplay of parent and child coping responses in understanding child functioning in the context of living with a parent with or without chronic pain

Elke Van LierdeLiesbet GoubertTim LammensLamia Ben BrahimEva Van den BusscheTine Vervoort

A1 Journal Article in CLINICAL JOURNAL OF PAIN

The pitfalls and promise of liquid biopsies for diagnosing and treating solid tumors in children : a review

Ruben Van PaemelROSALIE VLUGKatleen De PreterNadine Van RoyFranki SpelemanLeen WillemsTim LammensGenevieve LaureysGudrun SchleiermacherGodelieve AM Tytgat et al.

A1 Journal Article in EUROPEAN JOURNAL OF PEDIATRICS

2019

Deciphering molecular heterogeneity in pediatric AML using a cancer vs normal transcriptomic approach

Barbara DepreterMattias HofmansEva TerrasAnne UyttebroeckAn Van DammeAlina FersterJutte Van der Werff Ten BoschMarie-Françoise DresseKarl VandepoeleBarbara De Moerloose et al.

Deciphering molecular heterogeneity in pediatric AML using a cancer vs normal transcriptomic approach

Barbara DepreterMattias HofmansEva TerrasAnne UyttebroeckAn Van DammeAlina FersterJutte van der Werff ten BoschMarie-Françoise DresseKarl VandepoeleBarbara De Moerloose et al.

Genetic characterization and therapeutic targeting of MYC-rearranged T cell acute lymphoblastic leukaemia

Gloria MilaniFilip MatthijssensWouter Van LoockeKaat DurinckJuliette RoelsSofie PeirsMorgan ThénozTim PietersLindy ReunesBéatrice Lintermans et al.

A1 Journal Article in BRITISH JOURNAL OF HAEMATOLOGY

Long non-coding RNAs as novel therapeutic targets in juvenile myelomonocytic leukemia : proof of concept study

Mattias HofmansBarbara DepreterTim LammensHelene CaveChristian FlothoHenrik HasleValerie de HaasCharlotte M. NiemeyerJan StaryPieter Van Vlierberghe et al.

Minimally invasive classification of pediatric solid tumors using reduced representation bisulfite sequencing of cell-free DNA : a proof-of-principle study

Ruben Van PaemelAndries De KokerCharlotte VandeputteLieke van ZogchelTim LammensGenevieve LaureysJo VandesompeleGudrun SchleiermacherMathieu ChicardNadine Van Roy et al.

Non-invasive classification of pediatric tumor types using reduced representation bisulfite sequencing of cell-free DNA : a proof-of-principle study

Ruben Van PaemelA. De KokerCharlotte VandeputteL. M. J. van ZogchelM. ChicardTim LammensJo VandesompeleNadine Van RoyG. SchleiermacherG. A. M. Tytgat et al.

Noonan syndrome-associated myeloproliferative disorder with somatically acquired monosomy 7 : impact on clinical decision making

Mattias HofmansRieke SchroederTim LammensChristian FlothoCharlotte NiemeyerNadine Van RoyWim DecaluweJan PhilippéBarbara De Moerloose

A1 Journal Article in BRITISH JOURNAL OF HAEMATOLOGY

Novel strategy for rapid functional in vivo validation of oncogenic drivers in haematological malignancies

Tim PietersSara T'SasLisa DemoenAndré Pedro Pinto De AlmeidaLieven HaenebalckeFilip MatthijssensKelly LemeireJinke D'HontFrédérique VanrockeghemTino Hochepied et al.

A1 Journal Article in SCIENTIFIC REPORTS

Pinpointing a potential role for CLEC12B in cancer predisposition through familial exome sequencing

Charlotte DerpoorterKarl VandepoeleAraceli Diez FraileKatrien VandemeulebroeckeBram De WildeFranki SpelemanNadine Van RoyTim LammensGenevieve Laureys

A1 Journal Article in PEDIATRIC BLOOD & CANCER

Response-guided chemotherapy for pediatric acute myeloid leukemia without hematopoietic stem cell transplantation in first complete remission: Results from protocol DB AML-01

Barbara De MoerlooseArdine ReedijkGeertruida H. de BockTim LammensValerie de HaasBarbara DenysLaurence DedekenMarry M. van den Heuvel-EibrinkMaroeska te LooAnne Uyttebroeck et al.

A1 Journal Article in PEDIATRIC BLOOD & CANCER

Shallow whole genome sequencing on circulating cell-free DNA in pediatric cancer patients

Charlotte VandeputteJolien Van ThorreRuben Van PaemelAndries De KokerLeen WillemsJo Van DorpeMalaïka Van der LindenJilke De WildeBjörn MentenL. van Zogchel et al.

Shallow whole genome sequencing on circulating cell-free DNA in pediatric cancer patients

Charlotte VandeputteJolien Van ThorreRuben Van PaemelAndries De KokerLeen WillemsJo Van DorpeMalaïka Van der LindenJilke De WildeBjörn MentenLieke van Zogchel et al.

Shallow whole genome sequencing on circulating cell-free DNA in pediatric cancer patients

Charlotte VandeputteJolien Van ThorreRuben Van PaemelAndries De KokerLeen WillemsJo Van DorpeMalaïka Van der LindenJilke De WildeBjörn MentenLieke van Zogchel et al.

Successful copy number alteration profiling using circulating cell-free tumor DNA as a non-invasive alternative for tissue biopsies in pediatric cancer patients

Charlotte VandeputteJolien Van ThorreRuben Van PaemelAndries De KokerLeen WillemsJo Van DorpeMalaïka Van der LindenJilke De WildeBjörn MentenLieke van Zogchel et al.

TARP as immunotherapeutic target in AML expressed in the LSC compartment

Barbara DepreterKarin WeeningKarl VandepoeleM EssandBarbara De MoerlooseM ThemeliJ CloosD HanekampIne MoorsINGE D'HONT et al.

2018

A novel L-asparaginase with low L-glutaminase coactivity is highly efficacious against both T- and B-cell acute lymphoblastic leukemias in vivo

Hien Anh NguyenYing SuJenny Yu ZhangAleksandar AntanasijevicMichael CaffreyAmanda M SchalkLi LiuDamiano RondelliAnnie OhDolores L Mahmud et al.

A1 Journal Article in CANCER RESEARCH

Cancer-related mRNA expression analysis using a novel flow cytometry-based assay

Barbara DepreterJan PhilippéMAGALI MEULBarbara DenysKarl VandepoeleBarbara De MoerlooseTim Lammens

A1 Journal Article in CYTOMETRY PART B-CLINICAL CYTOMETRY

Circulating microRNA biomarkers for metastatic disease in neuroblastoma patients

Fjoralba ZekaAnneleen DecockAlan Van GoethemKatrien VanderheydenFleur DemuynckTim LammensHetty HelsmoortelJoëlle VermeulenRosa NogueraAna P. Berbegall et al.

A1 Journal Article in JCI INSIGHT

Circulating microRNA biomarkers for metastatic neuroblastoma

Fjoralba ZekaAlan Van GoethemTim LammensAnneleen DecockHetty HelsmoortelGenevieve LaureysMichael HogartyEveline BarbieriJason ShohetFrank Berthold et al.

Current understanding and future research priorities in malignancy associated with inborn errors of immunity and DNA repair disorders : the perspective of an interdisciplinary working group

Simon BomkenJutte van der Werff Ten BoschAndishe AttarbaschiChris M. BaconArndt BorkhardtKaan BoztugUte FischerFabian HauckRoland P. KuiperTim Lammens et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Event-free survival of infants and toddlers enrolled in the HR-NBL-1/SIOPEN trial is associated with the level of neuroblastoma mRNAs at diagnosis

Maria V CorriasStefano ParodiAndrei TchirkovTim LammensAles VichaClaudia PasqualiniCatarina TrägerYania YáñezSandro DallorsoLuigi Varesio et al.

A1 Journal Article in PEDIATRIC BLOOD & CANCER

Exploring the long non-coding RNA landscape in juvenile myelomonocytic leukemia

Mattias HofmansTim LammensS BresolinH CavéC FlothoH HasleHetty HelsmoortelM Van den Heuvel-EibrinkC NiemeyerJ Stary et al.

Genes at the crossroad of primary immunodeficiencies and cancer

Charlotte DerpoorterVictoria Bordon MariaGenevieve LaureysFilomeen HaerynckTim Lammens

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Leukaemic stem cell load at diagnosis predicts the development of relapse in young acute myeloid leukaemia patients

Diana HanekampBarbara DenysGertjan JL KaspersJeroen G te MarveldeGerrit Jan SchuurhuisValerie De HaasBarbara De MoerlooseEveline S de BontC Michel ZwaanAnja de Jong et al.

A1 Journal Article in BRITISH JOURNAL OF HAEMATOLOGY

Non-invasive differential diagnosis of neuroblastoma with other paediatric solid tumors using methylation profiling of circulating cell-free DNA

Ruben Van PaemelAnneleen DecockCharlotte VandeputteTim LammensGenevieve LaureysFranki SpelemanWim Van CriekingeNadine Van RoyJo VandesompeleKatleen De Preter et al.

Non-invasive differential diagnosis of neuroblastoma with other paediatric solid tumors using methylation profiling of circulating cell-free DNA

Ruben Van PaemelAnneleen DecockCharlotte VandeputteTim LammensGenevieve LaureysFranki SpelemanWim Van CriekingeNadine Van RoyJo VandesompeleKatleen De Preter et al.

Non-invasive differential diagnosis of neuroblastoma with other paediatric solid tumors using methylation profiling of circulating cell-free DNA

Ruben Van PaemelAnneleen DecockCharlotte VandeputteTim LammensGenevieve LaureysFranki SpelemanWim Van CriekingeNadine Van RoyJo VandesompeleKatleen De Preter et al.

Pre-clinical evaluation of second generation PIM inhibitors for the treatment of T-cell acute lymphoblastic leukemia and lymphoma

Renate De SmedtSofie PeirsJulie MorscioFilip MatthijssensJuliette RoelsLindy ReunesBéatrice LintermansSteven GoossensTim LammensNadine Van Roy et al.

A1 Journal Article in HAEMATOLOGICA

Predisposing mutations in hippo signaling reveal an actionable target in Burkitt lymphoma

Charlotte DerpoorterKatrien VandemeulebroeckeTieneke BautersJan PhilippéGenevieve LaureysTim Lammens

Recurrently affected genes in juvenile myelomonocytic leukaemia

Julia C ObenauerFrancois G KavelaarsMathijs A SandersAndrica CH de VriesValerie de HaasH Berna BeverlooBarbara De MoerlooseTim LammensMichael DworzakRemco M Hoogenboezem et al.

A1 Journal Article in BRITISH JOURNAL OF HAEMATOLOGY

Retrospective study of infant leukaemia in the University Hospitals of Leuven and Ghent

Barbara De MoerlooseE NauwynckK ArtsLeen WillemsV LabarqueTim LammensA Uyttebroeck

A2 Journal Article in BELGIAN JOURNAL OF HEMATOLOGY

The genetic basis and cell of origin of mixed phenotype acute leukaemia

Thomas B. AlexanderZhaohui GuIlaria IacobucciKirsten DickersonJohn K. ChoiBeisi XuDebbie Payne-TurnerHiroki YoshiharaMignon L. LohJohn Horan et al.

A1 Journal Article in NATURE

The long non-coding RNA landscape in juvenile myelomonocytic leukemia

Mattias HofmansTim LammensHetty HelsmoortelSilvia BresolinHélène CavéChristian FlothoHenrik HasleMarry M van den Heuvel-EibrinkCharlotte NiemeyerJan Stary et al.

A1 Journal Article in HAEMATOLOGICA

The potential of methylome sequencing in the diagnostic work : up of pediatric solid tumors

Ruben Van PaemelCharlotte VandeputteBram De WildeKatleen De PreterNadine Van RoyJo VandesompeleTim LammensWim Van CriekingeP. UltzNico Callewaert et al.

2017

Digital multiplex ligation-dependent probe amplification for detection of key copy number alterations in T- and B-cell lymphoblastic leukemia

Anne Benard-SlagterIlse ZondervanKarel de GrootFarzaneh GhazaviVirinder SarhadiPieter Van VlierbergheBarbara De MoerlooseClaire SchwabKim VettenrantaChristine J Harrison et al.

A1 Journal Article in JOURNAL OF MOLECULAR DIAGNOSTICS

Exome sequencing to identify novel neuroblastoma predisposition genes

Charlotte DerpoorterKarl VandepoeleAraceli Diez FraileKatrien VandemeulebroeckeNadine Van RoyBram De WildeTim LammensGenevieve Laureys

Genetic insights in ETV6/RUNX1-positive B-cell precursor acute lymphoblastic leukaemia

Farzaneh GhazaviTim LammensPieter Van VlierbergheBarbara De Moerloose

A2 Journal Article in BELGIAN JOURNAL OF HEMATOLOGY

Identification of genetic aberrations predisposing to familial Burkitt lymphoma using whole genome sequencing

Ruben Van PaemelCharlotte DerpoorterRein DemuynckEva TerrasBram De WildeTim LammensGenevieve Laureys

Long non-coding RNAs in leukemia : biology and clinical impact

Tim LammensKaat DurinckAnnelynn WallaertFranki SpelemanPieter Van Vlierberghe

A1 Journal Article in CURRENT OPINION IN HEMATOLOGY

Novel molecular genetic insights in paediatric B-cell precursor acute lymphoblastic leukaemia

Farzaneh GhazaviTim LammensPieter Van VlierbergheBarbara De Moerloose

A2 Journal Article in BELGIAN JOURNAL OF HEMATOLOGY

Shallow whole genome sequencing on circulating cell-free DNA allows reliable non-invasive copy number profiling in neuroblastoma patients

Nadine Van RoyMalaïka Van der LindenPauline DepuydtBjörn MentenAnnelies DheedeneCharlotte VandeputteJo Van DorpeGenevieve LaureysMarjolijn RenardTom Sante et al.

Shallow whole genome sequencing on circulating cell-free DNA allows reliable noninvasive copy-number profiling in neuroblastoma patients

Nadine Van RoyMalaïka Van der LindenBjörn MentenAnnelies DheedeneCharlotte VandeputteJo Van DorpeGenevieve LaureysMarleen RenardTom SanteTim Lammens et al.

A1 Journal Article in CLINICAL CANCER RESEARCH

Unravelling the biology of juvenile myelomonocytic leukaemia using transcriptomics

Hetty HelsmoortelTim LammensPieter Van VlierbergheBarbara De Moerloose

A2 Journal Article in BELGIAN JOURNAL OF HEMATOLOGY

2016

A novel multiplex NGS-based digital MLPA assay for copy number detection of 700 target sequences in childhood acute lymphoblastic leukemia

Anne BenardIlse ZondervanJan SchoutenKarel de GrootFarzaneh GhazaviVirinder SarhadiPieter Van VlierbergheBarbara De MoerlooseChristine HarrisonClaire Schwab et al.

Digital MLPA(TM) for copy number detection in childhood acute lymphoblasic leukemia : a novel multiplex NGS-based assay

A BenardBarbara De MoerlooseI ZondervanFarzaneh GhazaviV SarhadiPieter Van VlierbergheTim LammensS KnuutilaS Savola

Genetic characterization and therapeutic targeting of MYC translocated pediatric T-cell acute lymphoblastic leukemia

Gloria MilaniKaat DurinckFilip MatthijssensSofie PeirsTim PietersLindy ReunesBéatrice LintermansNiels VandammeTim LammensYunlei Li et al.

Genomic landscape of pediatric mixed phenotype acute leukemia

Thomas B AlexanderZhaohui GuJohn K ChoiMignon LohJohn HoranBarbara BuldiniGiuseppe BassoSarah ElitzurValerie de HaasC Michel Zwaan et al.

Identification of candidate oncogenes and chromosomal breakpoint sequencing by targeted locus amplification in T-cell acute lymphoblastic leukemia

Eric VroegindeweijTim LammensKirsten Cante-BarrettErik SplinterA UyttebroeckJessica GC Buijs-GladdinesWilco SmitsPeter VandenbergheRenate De SmedtBarbara De Moerloose et al.

LIN28B is over-expressed in specific subtypes of pediatric leukemia and regulates lncRNA H19

Hetty HelsmoortelBarbara De MoerlooseTim PietersFarzaneh GhazaviSilvia BresolinHelene CaveAndrica de VriesValerie de HaasChristian FlothoVeerle Labarque et al.

A1 Journal Article in HAEMATOLOGICA

LIN28B is overexpressed in pediatric leukemia and regulates LNCRNA H19

Hetty HelsmoortelBarbara De MoerlooseSilvia BresolinHélèe CavéChristian FlothoCharlotte NiemeyerJan StaryMarry van den Heuvel-EibrinkPieter Van VlierbergheTim Lammens

LIN28B overexpression defines a novel fetal-like subgroup of juvenile myelomonocytic leukemia

Hetty HelsmoortelSilvia BresolinTim LammensHélène CavéPeter NoellkeAurélie CayeFarzaneh GhazaviAndrica de VriesHenrik HasleVeerle Labarque et al.

A1 Journal Article in BLOOD

Leukemia in infants : a retrospective study (1992-2014) in the Ghent University Hospital

Elise NauwynckTim LammensVincent VakaetN Van DammeYves BenoitVeerle MondelaersEls VandecruysGenevieve LaureysL VakaetBarbara De Moerloose

Novel molecular genetic insights in pediatric B-cell precursor acute lymphoblastic leukemia

Farzaneh GhazaviBarbara De MoerloosePieter Van VlierbergheTim Lammens

RPPA-Based protein profiling reveals enhanced PI3K/AKT/mTOR signaling in ETV6/RUNX1-positive acute lymphoblastic leukemia patients with low CD200 expression

Farzaneh GhazaviValentina SerafinPieter RondouTim LammensFranki SpelemanBenedetta AccordiBarbara De MoerloosePieter Van Vlierberghe

Unique long non-coding RNA expression signature in ETV6/RUNX1-Driven B-cell precursor acute lymphoblastic leukemia

Farzaneh GhazaviBarbara De MoerlooseWouter Van LoockeAnnelynn WallaertAlina FersterMarleen BakkusGeneviève PlatEric DelabesseAnne UyttebroeckFilip Van Nieuwerburgh et al.

Unique long non-coding RNA expression signature in ETV6/RUNX1-driven B-cell precursor acute lymphoblastic leukemia

Farzaneh GhazaviBarbara De MoerlooseWouter Van LoockeAnnelynn WallaertHetty HelsmoortelAlina FersterMarleen BakkusGeneviève PlatEric DelabesseAnne Uyttebroeck et al.

A1 Journal Article in ONCOTARGET

Unraveling the biology of juvenile myelomonocytic leukemia using transcriptomics

Hetty HelsmoortelBarbara De MoerlooseTim LammensPieter Van Vlierberghe

2015

CD200/BTLA deletions in pediatric precursor B-cell acute lymphoblastic leukemia treated according to the EORTC-CLG 58951 protocol

Farzaneh GhazaviEmmanuelle ClappierTim LammensStefan SuciuAurélie CayeSamira ZegrariMarleen BakkusNathalie GrardelYves BenoitOdile Minckes et al.

A1 Journal Article in HAEMATOLOGICA

Excellent outcome in pediatric AML with response guided chemotherapy without allogeneic HSCT in first complete remission results from prococol DB-AML01

Eveline de BontArdine ReedijkTim LammensValerie de HaasBarbara DenysLaurence DedekenMarry van den HeuvelMaroeska te LooAnne UyttebroeckAn Vandamme et al.

MicroRNA-193b-3p acts as a tumor suppressor by targeting the MYB oncogene in T-cell acute lymphoblastic leukemia

Evelien MetsJoni Van der MeulenGert Van PeerMichael BoicePieter MestdaghInge Van de WalleTim LammensSteven GoossensBarbara De MoerlooseYves Benoit et al.

A1 Journal Article in LEUKEMIA

Molecular basis and clinical significance of genetic aberrations in B-cell precursor acute lymphoblastic leukemia

Farzaneh GhazaviTim LammensNadine Van RoyBruce PoppeFranki SpelemanYves BenoitPieter Van VlierbergheBarbara De Moerloose

A1 Journal Article in EXPERIMENTAL HEMATOLOGY

Mutational spectrum of juvenile myelomonocytic leukemia

J ObenauerF KavelaarsACH de VriesM SandersV de HaasBarbara De MoerlooseTim LammensM DworzakC NiemeyerP Valk et al.

Novel biological insights in T-cell acute lymphoblastic leukemia

Kaat DurinckSteven GoossensSofie PeirsAnnelynn WallaertWouter Van LoockeFilip MatthijssensTim PietersGloria MilaniTim LammensPieter Rondou et al.

A1 Journal Article in EXPERIMENTAL HEMATOLOGY

The H3K27me3 demethylase UTX is a gender-specific tumor suppressor in T-cell acute lymphoblastic leukemia

Joni Van der MeulenViraj SanghviKonstantinos MavrakisKaat DurinckFang FangFilip MatthijssensPieter RondouMonica RosenTim PietersPeter Vandenberghe et al.

A1 Journal Article in BLOOD

The long non-coding RNA H19 is regulated by LIN28B

Hetty HelsmoortelBarbara De MoerlooseTim PietersFarzaneh GhazaviS BresolinH CavéA CayeACH de VriesC FlothoV Labarque et al.

2014

ABT-199 mediated inhibition of BCL-2 as a novel therapeutic strategy in T-cell acute lymphoblastic leukemia

Sofie PeirsFilip MatthijssensSteven GoossensInge Van de WalleKatia RuggeroCharles E de BockSandrine DegryseKirsten Canté-BarrettDelphine BriotEmmanuelle Clappier et al.

A1 Journal Article in BLOOD

ABT-199 mediated inhibition of BCL-2 as a novel therapeutic strategy in early immature T-cell acute lymphoblastic leukemia

Sofie PeirsFilip MatthijssensSteven GoossensKirsten Canté-BarrettTim LammensBarbara De MoerlooseYves BenoitJean SoulierBruce PoppeTom Taghon et al.

ABT-199 mediated inhibition of BCL2 as a novel therapeutic strategy in T-cell acute lymphoblastic leukemia

Sofie PeirsFilip MatthijssensSteven GoossensCharles De BockKirsten Canté-BarrettTim LammensInge Van de WalleBarbara De MoerlooseYves BenoitBruce Poppe et al.

Acute lymphoblastic leukemia in children with Down syndrome: a retrospective analysis from the Ponte di Legno study group

Trudy D BuitenkampShai IzraeliMartin ZimmermannErik ForestierNyla A HeeremaMarry M van den Heuvel-EibrinkRob PietersCarin M KorbijnLewis B SilvermanKjeld Schmiegelow et al.

A1 Journal Article in BLOOD

Age-associated differential microRNA levels in human follicular fluid reveal pathways potentially determining fertility and success of in vitro fertilization

Araceli Diez FraileTim LammensKelly TillemanWojciech WitkowskiBruno VerhasseltPetra De SutterYves BenoitMarc EspeelKatharina D'Herde

A1 Journal Article in HUMAN FERTILITY

Juvenile myelomonocytic leukaemia: the quest for more specific therapies

Hetty HelsmoortelTim LammensNadine Van RoyJan PhilippéPascale De PaepeYves BenoitFranki SpelemanPieter Van VlierbergheBarbara De Moerloose

A2 Journal Article in BELGIAN JOURNAL OF HEMATOLOGY

LIN28B defines an aggressive subtype of juvenile myelomonocytic leukemia

Hetty HelsmoortelTim LammensFarzaneh GhazaviAurelie CayeHélène CavéChristian FlothoCharlotte NiemeyerJan StarySilvia BresolinRiccardo Masetti et al.

Mind the gap : translation of genetic research into clinical care in the context of RUNX1-associated leukaemia predisposition

Tim RippergerAlina FersterTim LammensBarbara De MoerlooseLaurence RozenNadira AzziCharlotte M NiemeyerBrigitte SchlegelbergerDoris Steinemann

Prognostic relevance of BTLA/CD200 deletion in pediatric pre-B cell acute lymphoblastic leukemia

Farzaneh GhazaviTim LammensStefan SuciuMarleen BakkusHélène CavéFranki SpelemanYves BenoitBarbara De MoerloosePieter Van Vlierberghe

Prognostic relevance of CD200/BTLA deletions in pediatric precursor-B cell acute lymphoblastic leukemia treated according to the EORTD-CLG 58951 protocol

Farzaneh GhazaviTim LammensEmmanuelle ClappierStefan SuciuAurélie CayeSamira ZegrariMarleen BakkusNathalie GrardelYves BenoitYves Bertrand et al.

The ASH1-RELATED3 SET-domain protein controls cell division competence of the meristem and the quiescent center of the Arabidopsis primary root

Robert KumpfTage ThorstensenMohummad Aminur RahmanJefri HeymanH Zeynep NensethTim LammensUllrich HerrmannRanjan SwarupSilje Veie VeisethGitika Emberland et al.

A1 Journal Article in PLANT PHYSIOLOGY

2013

Delayed elemination of methotrexate by cola beverages in a pediatric acute lymphoblastic leukemia population

Tieneke BautersTim LammensPauline BelinYves BenoitHugo RobaysBarbara De Moerloose

A1 Journal Article in LEUKEMIA & LYMPHOMA

Long non-coding RNAs in pluripotent stem cell biology

Tim LammensINGE D'HONTKatharina D'HerdeYves BenoitAraceli Diez Fraile

A1 Journal Article in VETERINARY QUARTERLY

The calcium-sensing receptor as a regulator of cellular fate in normal and pathological conditions

Araceli Diez FraileTim LammensYves BenoitKatharina D'Herde

A1 Journal Article in CURRENT MOLECULAR MEDICINE

The need for transparency and good practices in the qPCR literature

Stephen A BustinVladimir BenesJeremy GarsonJan HellemansJim HuggettMikael KubistaReinhold MuellerTania NolanMichael W PfafflGregory Shipley et al.

A1 Journal Article in NATURE METHODS

miRNAs distinguish children with myelodysplastic syndrome from healthy donors

Hetty HelsmoortelTim LammensPieter MestdaghNadine Van RoyAnne UyttebroeckAlina FersterYves BenoitJo VandesompeleFranki SpelemanPieter Van Vlierberghe et al.

miRNAs distinguish children with myelodysplastic syndrome from healthy donors

Hetty HelsmoortelTim LammensPieter MestdaghNadine Van RoyAnne UyttebroeckAlina FersterYves BenoitJo VandesompeleFranki SpelemanPieter Van Vlierberghe et al.

2012

Improved risk stratification and outcome prediction in children with average risk 1 precursor-B acute lymphoblastic leukemia using a 19-microRNA signature

Farzaneh GhazaviTim LammensStefan SuciuGenevieve LaureysMarleen BakkusAlina FersterAnne UyttebroeckPatrick LutzHélène CavéGeneviève Plat et al.

Improved risk-stratification and outcome prediction in children with average risk precursor-B acute lymphoblastic leukemia using a 19-microRNA signature

Farzaneh GhazaviTim LammensStefan SuciuGenevieve LaureysMarleen BakkusAlina FersterAnne UyttebroeckPatrick LutzHélène CavéGeneviève Plat et al.

Isolation of disseminated neuroblastoma cells from bone marrow aspirates for pretreatment risk assessment by array comparative genomic hybridization

Mado VandewoestyneCandy KumpsKatrien SwertsBjörn MentenTim LammensJan PhilippéKatleen De PreterGenevieve LaureysNadine Van RoyFranki Speleman et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF CANCER

N-Cadherin in neuroblastoma disease : expression and clinical significance

Tim LammensKatrien SwertsLara DeryckeANNEMIE DE CRAEMERSara De BrouwerKatleen De PreterNadine Van RoyJo VandesompeleFranki SpelemanJan Philippé et al.

A1 Journal Article in PLOS ONE

Study of the miRNome of childhood myelodysplastic syndrome

Hetty HelsmoortelTim LammensNadine Van RoyAnne UyttebroeckAlina FersterYves BenoitFranki SpelemanBarbara De Moerloose

2011

Atypical E2F activity coordinates PHR1 photolyase gene transcription with endoreduplication onset

Amandine RadziejwoskiKobe VliegheTim LammensBarbara BerckmansSara MaesMarcel AK JansenClaudia KnappeAndreas AlbertHarald K SeidlitzGünther Bahnweg et al.

A1 Journal Article in EMBO JOURNAL

Light-dependent regulation of DEL1 is determined by the antagonistic action of E2Fb and E2Fc

Barbara BerckmansTim LammensHilde Van Den DaeleZoltan MagyarLaszlo BögreLieven De Veylder

A1 Journal Article in PLANT PHYSIOLOGY

MicroRNA-based diagnosis, prognosis and treatment of paediatric acute lymphoblastic leukaemia

Tim LammensFarzaneh GhazaviFranki SpelemanYves BenoitBarbara De Moerloose

A2 Journal Article in BELGIAN JOURNAL OF HEMATOLOGY

2010

Microrna expression in pediatric precursor-B acute lymphoblastic leukemia: biology, classification and prognosis

Tim LammensBarbara De MoerlooseJonas Van BaelenJoni Van der MeulenPieter MestdaghBruno VerhasseltJan PhilippéFranki SpelemanYves Benoit

The MCM-Binding Protein ETG1 Aids Sister Chromatid Cohesion Required for Postreplicative Homologous Recombination Repair

Naoki TakahashiMauricio Quimbaya GomezVeit SchubertTim LammensKlaas VandepoeleIngo SchubertMinami MatsuiDirk InzéGeert BerxLieven De Veylder

A1 Journal Article in PLOS GENETICS

2009

APC/C-CCS52A complexes control meristem maintenance in the Arabidopsis root

Marleen VanstraelenMikhail BalobanOlivier Da InesAntonietta CultroneTim LammensVéronique BoudolfSpencer BrownLieven De VeylderPeter MergaertEva Kondorosi

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Apoptotic, necrotic and autophagic cell death types in pathophysiological conditions: morphological and histological aspects

Araceli Diez FraileTim LammensKatharina D'Herde

Bookchapter in Phagocytosis of dying cells : from molecular mechanisms to human disease

Atypical E2Fs: new players in the E2F transcription factor family

Tim LammensJing LiGustavo LeoneLieven De Veylder

A1 Journal Article in Trends in Cell Biology

CDKB1;1 forms a functional complex with CYCA2;3 to suppress endocycle onset

Véronique BoudolfTim LammensJoanna BorucJelle Van LeeneHilde Van Den DaeleSara MaesGert Van IsterdaelEugenia RussinovaEva KondorosiErwin Witters et al.

A1 Journal Article in Plant Physiology

Quantitative RNA expression analysis with Affymetrix Tiling 1.0R arrays identifies new E2F target genes

Naïra NaouarKlaas VandepoeleTim LammensTineke CasneufGeorg ZellerPaul Van HummelenDetlef WeigelGunnar RätschDirk InzéMartin Kuiper et al.

A1 Journal Article in Plant Journal

2008

Atypical E2F activity restrains APC/C-CCS52A2 function obligatory for endocycle onset

Tim LammensVéronique BoudolfLeila Kheibarshekan AslL Panagiotis ZalmasTarik GaamoucheSara MaesMarleen VanstraelenEva KondorosiNicholas B La ThangueWilly Govaerts et al.

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The DNA replication checkpoint aids survival of plants deficient in the novel replisome factor ETG1

Naoki TakahashiTim LammensVéronique BoudolfSara MaesTakeshi YoshizumiGeert De JaegerErwin WittersDirk InzéLieven De Veylder

A1 Journal Article in EMBO JOURNAL