Research Explorer

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Researcher

Thomas Naert

Publications & Research Data

Awards & Distinctions

30 Results

2025

Loss of function of the zinc finger homeobox 4 gene, ZFHX4, underlies a neurodevelopmental disorder

Maria del Rocio Pérez BacaMaría Palomares-BraloMichiel VanhooydonckLisa HamerlinckEva D'haeneSebastian LeimbacherEva JacobsLaurenz De CockErika D'haenensAnnelies Dheedene et al.

A1 Journal Article in AMERICAN JOURNAL OF HUMAN GENETICS

Precise, predictable genome integrations by deep-learning-assisted design of microhomology-based templates

Thomas NaertTaiyo YamamotoShuting HanRuth RöckMelanie HornPhilipp BethgeNikita VladimirovFabian F. VoigtJoana Figueiro-SilvaRuxandra Bachmann-Gagescu et al.

A1 Journal Article in NATURE BIOTECHNOLOGY

2024

Benchtop mesoSPIM : a next-generation open-source light-sheet microscope for cleared samples

Nikita VladimirovFabian F. VoigtThomas NaertGabriela R. AraujoRuiyao CaiAnna Maria ReussShan ZhaoPatricia SchmidSven HildebrandMartina Schaettin et al.

A1 Journal Article in NATURE COMMUNICATIONS

CRISPR/Cas9 mediated disruption of an evolutionary conserved putative enhancer in the mab21l2 locus induces developmental eye anomalies in Xenopus tropicalis

Münevver Burcu CicekdalFabiola CeroniRichard HoltThomas NaertSoeren S. LienkampElena SorokinElena SeminaNicolas ChassaingNicola RaggeElfride De Baere et al.

Decoding the non-coding regulatory genome : modelling of eye enhancerophathies in Xenopus tropicalis

Münevver Burcu CicekdalKris VleminckxElfride De BaereThomas Naert

Deletion upstream of MAB21L2 highlights the importance of evolutionarily conserved non-coding sequences for eye development

Fabiola CeroniMünevver Burcu CicekdalRichard HoltElena SorokinaNicolas ChassaingSamuel ClokieThomas NaertLidiya V. TalbotSanaa MuheisenDorine A. Bax et al.

A1 Journal Article in NATURE COMMUNICATIONS

Reflective multi-immersion microscope objectives inspired by the Schmidt telescope

Fabian F. VoigtAnna Maria ReussThomas NaertSven HildebrandMartina SchaettinAdriana L. HotzLachlan WhiteheadArmin BahlStephan C. F. NeuhaussAlard Roebroeck et al.

A1 Journal Article in NATURE BIOTECHNOLOGY

2023

Genetic variants in ARHGEF6 cause congenital anomalies of the kidneys and urinary tract in humans, mice, and frogs

V. KlämbtF. BuergerC. WangThomas NaertK. RichterT. NauthA. C. WeissT. SieckmannE. LaiD. Connaughton et al.

A1 Journal Article in JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

HNF1B alters an evolutionarily conserved nephrogenic program of target genes

Kelli GrandMartine StoltzLudovica RizzoRuth RoeckMichael M. KaminskiGabriela SalinasMaike GetwanThomas NaertRoman PichlerSoeren S. Lienkamp

A1 Journal Article in JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Mutations in the histone methyltransferase Ezh2 drive context-dependent leukemia in Xenopus tropicalis

Dieter TulkensMarthe BoelensThomas NaertMarjolein CarronSuzan DemuynckSylviane DewaeleGert Van IsterdaelDavid CreytensTim PietersSteven Goossens et al.

A1 Journal Article in LEUKEMIA

2022

Identifying and characterizing EZH2 as a druggable dependency factor for desmoid tumors in a genetic Xenopus tropicalis model for Gardner's Syndrome

Thomas NaertDieter TulkensTom Van NieuwenhuysenJoanna PrzybylSuzan DemuynckMushriq Al-JazraweMatt van de RijnBenjamin AlmanKim De LeenheerPaul Coucke et al.

2021

CRISPR-SID : identifying EZH2 as a druggable target for desmoid tumors via in vivo dependency mapping

Thomas NaertDieter TulkensTom Van NieuwenhuysenJoanna PrzybylSuzan DemuynckMatt van de RijnMushriq Al-JazraweBenjamin A. AlmanPaul CouckeKim De Leeneer et al.

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Deep learning is widely applicable to phenotyping embryonic development and disease

Thomas NaertOzgun CicekPaulina OgarMax BurgiNikko-Ideen ShaidaniMichael M. KaminskiYuxiao XuKelli GrandMarko VujanovicDaniel Prata et al.

A1 Journal Article in DEVELOPMENT

2020

Maximizing CRISPR/Cas9 phenotype penetrance applying predictive modeling of editing outcomes in Xenopus and zebrafish embryos

Thomas NaertDieter TulkensNicole A. EdwardsMarjolein CarronNikko-Ideen ShaidaniMarcin WlizlaAnnekatrien BoelSuzan DemuynckMarko E. HorbPaul Coucke et al.

A1 Journal Article in SCIENTIFIC REPORTS

RBL1 (p107) functions as tumor suppressor in glioblastoma and small-cell pancreatic neuroendocrine carcinoma in Xenopus tropicalis

Thomas NaertDionysia DimitrakopoulouDieter TulkensSuzan DemuynckMarjolein CarronRivka NoelandersLiza EeckhoutGert Van IsterdaelDieter DeforceChristian Vanhove et al.

A1 Journal Article in ONCOGENE

2019

CRISPR/Cas9-mediated cancer modeling and identification of cancer cell vulnerabilities in Xenopus tropicalis

Thomas NaertKris Vleminckx

Homozygous null TBX4 mutations lead to posterior amelia with pelvic and pulmonary hypoplasia

Ariana KariminejadEmmanuelle Szenker-RaviCaroline LekszasHoma TajsharghiAli-Reza MoslemiThomas NaertHong Tran ThiFatemeh AhangariMinoo RajaeiMojila Nasseri et al.

A1 Journal Article in AMERICAN JOURNAL OF HUMAN GENETICS

2018

Cancer models in Xenopus tropicalis by CRISPR/Cas9 mediated knockout of tumor suppressors

Thomas NaertKris Vleminckx

Bookchapter in Xenopus : methods and protocols

CRISPR/Cas9 disease models in zebrafish and Xenopus : the genetic renaissance of fish and frogs

Thomas NaertKris Vleminckx

A2 Journal Article in DRUG DISCOVERY TODAY. TECHNOLOGIES

CRISPR/Cas9 mediated knockout of rcbtb1 in Xenopus tropicalis to model RCBTB1-associated retinal disease

Giulia AscariThomas NaertTom Van NieuwenhuysenMarjolein CarronSuzan DemuynckChris GuerinFrauke CoppietersKris VleminckxElfride De Baere

CRISPR/Cas9 mediated knockout of rcbtb1 in Xenopus tropicalis to model RCBTB1-associated retinal disease

Giulia AscariThomas NaertTom Van NieuwenhuysenSuzan DemuynckChris GuerinFrauke CoppietersKris VleminckxElfride De Baere

CRISPR/Cas9-mediated knockout of Rb1 in Xenopus tropicalis

Thomas NaertKris Vleminckx

Bookchapter in The retinoblastoma protein

Genotyping of CRISPR/Cas9 genome edited Xenopus tropicalis

Thomas NaertKris Vleminckx

Bookchapter in Xenopus : methods and protocols

Methods for CRISPR/Cas9 Xenopus tropicalis tissue-specific multiplex genome engineering

Thomas NaertKris Vleminckx

Bookchapter in Xenopus : methods and protocols

RSPO2 inhibition of RNF43 and ZNRF3 governs limb development independently of LGR4/5/6

Emmanuelle Szenker-RaviUmut AltunogluMarc LeushackeCelia Boss-LefevreMuznah KhatooHong Tran ThiThomas NaertRivka NoelandersAmin HajamohideenClaire Beneteau et al.

A1 Journal Article in NATURE

2017

CRISPR/Cas9 mediated knockout of rb1 and rbl1 leads to rapid and penetrant retinoblastoma development in Xenopus tropicalis

Thomas NaertRobin ColpaertTom Van NieuwenhuysenDionysia DimitrakopoulouDavid CreytensKris Vleminckx

TALENs and CRISPR/Cas9 fuel genetically engineered clinically relevant Xenopus tropicalis tumor models

Thomas NaertTom Van NieuwenhuysenKris Vleminckx

A1 Journal Article in GENESIS

2016

CRISPR/Cas9 mediated knockout of rb1 and rbl1 leads to rapid and penetrant retinoblastoma development in Xenopus tropicalis

Thomas NaertRobin ColpaertTom Van NieuwenhuysenDionysia DimitrakopoulouJ LJurgen HaustraeteAnnekatrien BoelWouter SteyaertTrees LepezDieter Deforce et al.

A1 Journal Article in SCIENTIFIC REPORTS

2015

TALEN mediated mutation of apc and β-catenin in Xenopus tropicalis as powerful models for Wnt driven cancer and Familial Adenomatous Polyposis (FAP)

Tom Van NieuwenhuysenThomas NaertDavid CreytensFrans Van RoyKris Vleminckx

TALEN-mediated apc mutation in Xenopus tropicalis phenocopies familial adenomatous polyposis

Tom Van NieuwenhuysenThomas NaertHong Tran ThiGriet Van ImschootSarah GeursEllen SandersDavid CreytensFrans Van RoyKris Vleminckx

A2 Journal Article in ONCOSCIENCE