Research Explorer

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Researcher

Thomas Heugebaert

Awards & Distinctions

60 Results

2024

Continuous flow scale-up of enantiospecific solid-to-solid photodecarbonylation chemistry through pulsed flow operation and inline crystallization

Bavo VandekerckhoveBart RuttensBert MettenChristian StevensThomas Heugebaert

Continuous flow scale-up of enantiospecific solid-to-solid photodecarbonylation chemistry through pulsed flow operation and inline crystallization

Bavo VandekerckhoveBart RuttensBert MettenChristian StevensThomas Heugebaert

Development of a solid-compatible continuous flow reactor for the paraformaldehyde slurry mediated 𝛼-hydroxymethylation of methyl vinyl ketone

Bavo VandekerckhoveLise Van CoillieBert MettenThomas HeugebaertChristian Stevens

A1 Journal Article in REACTION CHEMISTRY & ENGINEERING

Development of porous organic polymers as metal-free photocatalysts for the aromatization of N-heterocycles

Maarten DebruyneNathan RaeymackersHenk VrielinckSambhu RadhakrishnanEric BreynaertMaxime DelaeyAndreas LaemontKaren LeusJonas EveraertHannes Rijckaert et al.

A1 Journal Article in CHEMCATCHEM

Enhancing N-arylation productivity : the amplified potential of electrophotocatalysis in flow

Jolien De KetelaereThomas Heugebaert

A1 Journal Article in JOURNAL OF FLOW CHEMISTRY

Merging inline crystallization and pulsed flow operation to enable enantiospecific solid state photodecarbonylation

Bavo VandekerckhoveBart RuttensBert MettenChristian StevensThomas Heugebaert

Merging inline crystallization and pulsed flow operation to enable enantiospecific solid state photodecarbonylation

Bavo VandekerckhoveBart RuttensBert MettenChristian StevensThomas Heugebaert

A1 Journal Article in REACTION CHEMISTRY & ENGINEERING

Oxidative cleavage of lignin model substrates with Co(salen) catalyst : an experimental study on the effect of different reaction parameters in batch and continuous flow

Jonas MortierJoseph J. BozellChristian StevensThomas Heugebaert

A1 Journal Article in REACTION CHEMISTRY & ENGINEERING

2023

Chemical induction of hypocotyl rooting reveals extensive conservation of auxin signalling controlling lateral and adventitious root formation

Yinwei ZengInge VerstraetenHoang Khai TrinhRobin LardonSébastien SchotteDamilola OlatunjiThomas HeugebaertChristian StevensMussa QuareshyRichard Napier et al.

A1 Journal Article in NEW PHYTOLOGIST

Scale-up of solid state photodecarbonylation chemistry in a continuous flow setup

Bavo VandekerckhoveBart RuttensBert MettenChristian StevensThomas Heugebaert

2022

Practical Ferrioxalate Actinometry in Photoflow Reactors

Bavo VandekerckhoveNicola PiensBert MettenChristian StevensThomas Heugebaert

Practical actinometry in photoflow reactors

Bavo VandekerckhoveNicola PiensBert MettenChristian StevensThomas Heugebaert

Practical actinometry in photoflow reactors

Bavo VandekerckhoveNicola PiensBert MettenChristian StevensThomas Heugebaert

Practical ferrioxalate actinometry for the determination of photon fluxes in production-oriented photoflow reactors

Bavo VandekerckhoveNicola PiensBert MettenChristian StevensThomas Heugebaert

A1 Journal Article in ORGANIC PROCESS RESEARCH & DEVELOPMENT

2021

Arabidopsis hypocotyl adventitious root formation is suppressed by ABA signaling

Yinwei ZengInge VerstraetenHoang Khai TrinhThomas HeugebaertChristian StevensIrene Garcia-MaquilonPedro L. RodriguezSteffen VannesteDanny Geelen

A1 Journal Article in GENES

Synthesis of nitrile-functionalized polydentate N-heterocycles as building blocks for covalent triazine frameworks

Jonas EveraertMaarten DebruyneFlore Vanden BusscheKristof Van HeckeThomas HeugebaertPascal Van Der VoortVeronique Van SpeybroeckChristian Stevens

A1 Journal Article in SYNTHESIS-STUTTGART

2019

Continuous-flow synthesis of phenothiazine antipsychotics : a feasibility study

Marine MovsisyanLaurens De CoenThomas HeugebaertArno VerleeBart RomanChristian Stevens

A1 Journal Article in EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Design and visualization of second generation cyanoisoindole based fluorescent strigolactone analogs

Melissa Van OvertveldtLukas BraemSylwia Magdalena StrukAnna KaczmarekFrançois‐Didier BoyerRik Van DeunKris GevaertSofie GoormachtigThomas HeugebaertChristian Stevens

A1 Journal Article in PLANT JOURNAL

Electrophilic bromination in flow : a safe and sustainable alternative to the use of molecular bromine in batch

Reinout Van KerrebroeckPieter NaertThomas HeugebaertMatthias D'hoogheChristian Stevens

A1 Journal Article in MOLECULES

Gold and palladium mediated bimetallic catalysis : mechanistic investigation through the isolation of the organogold(I) intermediates

Arno VerleeThomas HeugebaertTom van der MeerPavel KerchevKristof Van HeckeFrank Van BreusegemChristian Stevens

A1 Journal Article in ACS CATALYSIS

Gold catalysis as a means and an end : access to novel strigolactone analogs and methodology study

Melissa Van OvertveldtChristian StevensThomas Heugebaert

Immobilization of Ir(I) complex on covalent triazine frameworks for C-H borylation reactions : a combined experimental and computational study

Norini TahirFrancesco Muniz MirandaJonas EveraertPieter TackThomas HeugebaertKaren LeusLaszlo VinczeChristian StevensVeronique Van SpeybroeckPascal Van Der Voort

A1 Journal Article in JOURNAL OF CATALYSIS

Immobilization of Ir(I) complex on covalent triazine frameworks for C–H borylation reactions: A combined experimental and computational study

Jonas EveraertNorini TahirFrancesco Muniz-MirandaPieter TackThomas HeugebaertKaren LeusLaszlo VinczeChristian StevensVeronique Van SpeybroeckPascal Van Der Voort

2018

Atom- and mass-economical continuous flow production of 3-chloropropionyl chloride and its subsequent amidation

Marine MovsisyanThomas HeugebaertBart RomanRudolf DamsRudy Van CampenhoutMatthias ConradiChristian Stevens

A1 Journal Article in CHEMISTRY-A EUROPEAN JOURNAL

Design of a mesoscale continuous-flow route toward lithiated methoxyallene

Sofie SeghersThomas HeugebaertMatthias MoensJolien SonckJoris ThybautChristian Stevens

A1 Journal Article in CHEMSUSCHEM

Domino reaction of a gold catalyzed 5-endo-dig cyclization and a [3,3]-sigmatropic rearrangement towards polysubstituted pyrazoles

Arno VerleeThomas HeugebaertTom van der MeerPavel KerchevFrank Van BreusegemChristian Stevens

A1 Journal Article in ORGANIC & BIOMOLECULAR CHEMISTRY

Synthesis and biological activity of oxazolopyrimidines

Laurens De CoenBart RomanMarine MovsisyanThomas HeugebaertChristian Stevens

A1 Journal Article in EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

2017

A chemoselective and continuous synthesis of m-sulfamoylbenzamide analogues

Arno VerleeThomas HeugebaertTom van der MeerPavel KerchevFrank Van BreusegemChristian Stevens

A1 Journal Article in BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY

Fifty years of (benz)oxaphospholene chemistry

Jan BertonThomas HeugebaertDavid VirieuxChristian Stevens

A1 Journal Article in CHEMISTRY-A EUROPEAN JOURNAL

Safely scaling hazardous chemistry through continuous flow technology

Marine MovsisyanThomas HeugebaertChristian Stevens

A1 Journal Article in CHIMICA OGGI-CHEMISTRY TODAY

Tandem addition of phosphite nucleophiles across unsaturated nitrogen-containing systems : mechanistic insights on regioselectivity

Wouter DebrouwerDietmar HertsenThomas HeugebaertEsma Birsen BoydasVeronique Van SpeybroeckSaron CatakChristian Stevens

A1 Journal Article in JOURNAL OF ORGANIC CHEMISTRY

2016

3-Imidoallenylphophonates: in situ formation and β-alkoxylation

Jan BertonThomas HeugebaertWouter DebrouwerChristian Stevens

A1 Journal Article in ORGANIC LETTERS

Safe, selective, and high-yielding synthesis of acryloyl chloride in a continuous-flow system

Marine MovsisyanThomas HeugebaertRudy DamsChristian Stevens

A1 Journal Article in CHEMSUSCHEM

2015

Efficient continuous-flow benzotriazole activation and coupling of amino acids

Sofie SeghersFrederik Van WaesAna CukalovicJean-Christophe MonbaliuJeroen De VisscherJoris ThybautThomas HeugebaertChristian Stevens

A1 Journal Article in JOURNAL OF FLOW CHEMISTRY

Elucidating the structural isomerism of fluorescent strigolactone analogue CISA-1

Hannelore GoossensThomas HeugebaertBusra DereliMelissa Van OvertveldtOzlem KarahanIlknur DoganMichel WaroquierVeronique Van SpeybroeckViktorya AviyenteSaron Catak et al.

A1 Journal Article in EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Gold superacid-catalyzed preparation of benzo[c]thiophenes

Wouter DebrouwerRuben SeigneurThomas HeugebaertChristian Stevens

A1 Journal Article in CHEMICAL COMMUNICATIONS

Homogeneous gold-catalyzed cyclization reactions of alkynes with N- and S-nucleophiles

Wouter DebrouwerThomas HeugebaertBart RomanChristian Stevens

A1 Journal Article in ADVANCED SYNTHESIS & CATALYSIS

Phosphonamide pyrabactin analogues as abscisic acid agonists

Melissa Van OvertveldtThomas HeugebaertInge VerstraetenDanny GeelenChristian Stevens

A1 Journal Article in ORGANIC & BIOMOLECULAR CHEMISTRY

Singlet-oxygen oxidation of 5-hydroxymethylfurfural in continuous flow

Thomas HeugebaertChristian StevensOliver Kappe

A1 Journal Article in CHEMSUSCHEM

Synthetic entries to and biological activity of pyrrolopyrimidines

Laurens De CoenThomas HeugebaertDaniel Garcia JimenezChristian Stevens

A1 Journal Article in CHEMICAL REVIEWS

2014

Functions incorporating a halogen and another group other than a halogen or a chalcogen

Bart RomanThomas HeugebaertChristian Stevens

Bookchapter in Reference module in chemistry, molecular sciences and chemical engineering

New strigolactone analogs as plant hormones with low activities in the rhizosphere

François-Didier BoyerAlexandre de Saint GermainJean-Bernard PouvreauGuillaume ClavéJean-Paul PilotAmélie RouxAmanda RasmussenStephen DepuydtDominique LauresserguesNicolas Frei dit Frey et al.

A1 Journal Article in MOLECULAR PLANT

On the discovery and development of tandem 1,4- and 1,2-addition of phosphites to 1-azadienes

Frederik Van WaesWouter DebrouwerThomas HeugebaertChristian Stevens

A1 Journal Article in ARKIVOC

Preparation of tetrasubstituted 3-phosphonopyrroles through hydroamination: scope and limitations

Wouter DebrouwerThomas HeugebaertChristian Stevens

A1 Journal Article in JOURNAL OF ORGANIC CHEMISTRY

Synthesis of 1-substituted epibatidine analogues and their in vitro and in vivo evaluation as α₄β₂ nicotinic acetylcholine receptor ligands

Thomas HeugebaertMelissa Van OvertveldtAnn De BlieckBenjamin WuytsPatrick AugustijnsEugenia Ponce-GámezAlicia RiveraDominic De GrooteRomain LefebvrePatrick Wouters et al.

A1 Journal Article in RSC ADVANCES

Synthesis of epibatidine analogues having a 2-substituted 2-azabicyclo[2.2.2]octane skeleton

Iris WautersAnn De BlieckKoen MuylaertThomas HeugebaertChristian Stevens

A1 Journal Article in EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

2013

A fluorescent alternative to the synthetic strigolactone GR24

Amanda RasmussenThomas HeugebaertCedrick MatthysRik Van DeunFrancois-Didier BoyerSofie GoormachtigChristian StevensDanny Geelen

A1 Journal Article in MOLECULAR PLANT

Assessment of the antineoplastic potential of chalcones in animal models

Bart RomanThomas HeugebaertMarc BrackeChristian Stevens

A1 Journal Article in CURRENT MEDICINAL CHEMISTRY

Synthetic entry into 1‑phosphono-3-azabicyclo[3.1.0]hexanes

Wouter DebrouwerThomas HeugebaertKristof Van HeckeChristian Stevens

A1 Journal Article in JOURNAL OF ORGANIC CHEMISTRY

2012

Biodeposited Pd/Au bimetallic nanoparticles as novel Suzuki catalysts

Thomas HeugebaertSimon De CorteTom SabbeTom HennebelWilly VerstraeteNico BoonChristian Stevens

A1 Journal Article in TETRAHEDRON LETTERS

Innovative entries to heterocyclic natural product analogues: strigolactone, rhodanine and epibatidine

Thomas HeugebaertChristian Stevens

Synthesis of isoindoles and related iso-condensed heteroaromatic pyrroles

Thomas HeugebaertBart RomanChristian Stevens

A1 Journal Article in CHEMICAL SOCIETY REVIEWS

2011

Application of microreactor technology for cyanohydrin production : extending the scope towards renewable resources

Ana CukalovicJean-Christophe MonbaliuBart RomanAnn De BlieckThomas HeugebaertJoris ThybautGuy MarinGeraldine HeynderickxChristian Stevens

Gold(III) chloride catalysed synthesis of 5-alkylidene-dihydrothiazoles

Thomas HeugebaertLeander VervaeckeChristian Stevens

A1 Journal Article in ORGANIC & BIOMOLECULAR CHEMISTRY

Synthesis of N-vinyl 2,2-bisphosphonoaziridines from 1,1-bisphosphono-2-aza-1,3-dienes

Pieter MortierFrederik Van WaesKurt MasscheleinThomas HeugebaertChristian Stevens

A1 Journal Article in TETRAHEDRON LETTERS

2010

A safe production method for acetone cyanohydrin

Thomas HeugebaertBart RomanAnn De BlieckChristian Stevens

A1 Journal Article in TETRAHEDRON LETTERS

A straightforward entry to 7-azabicyclo[2.2.1]heptane-1-carbonitriles in the synthesis of novel epibatidine analogues

Thomas HeugebaertJoke Van HeveleWouter CouckVicky BruggemanSarah Van der JeughtKurt MasscheleinChristian Stevens

A1 Journal Article in EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Cyclic tri- and pentavalent amidoesters and diamides with a stereogenic phosphorus atom in asymmetric synthesis, part I : stoichiometric reagents

Józef DrabowiczDorota KrasowskaAndrzej LopusinskiThomas HeugebaertChristian Stevens

A1 Journal Article in CURRENT ORGANIC CHEMISTRY

Selected five-membered phosphorus heterocycles containing a stereogenic phosphorus

Józef DrabowiczDorota KrasowskaAndrzej LopusinskiThomas HeugebaertChristian Stevens

Bookchapter in Phosphorus heterocycles II

2009

Gold(III) chloride catalyzed synthesis of 1-cyanoisoindoles

Thomas HeugebaertChristian Stevens

A1 Journal Article in ORGANIC LETTERS