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Researcher
Thomas De Beer
Profile
Projects
Publications & Research Data
Activities
Awards & Distinctions
Patents
383
Results
2026
Exploring twin-screw feeding behaviour across different loss-in-weight feeders
A. De Man
B. Van Snick
T. Verbeek
M. Otava
Ashish Kumar
Chris Vervaet
Valérie Vanhoorne
Thomas De Beer
A1
Journal Article
in
INTERNATIONAL JOURNAL OF PHARMACEUTICS
2026
In-line blend potency measurements of low-dose formulations using a novel deep-UV LIF probe in the feed frame of a rotary tablet press
Louis Bouckaert
Rohit Bhartia
Zhenqi Shi
Ray Reid
Ken Nguyen
Jason Micklewright
William Hug
Andrew Anderson
Tom Van Den Kerkhof
Mario Hellings
et al.
A1
Journal Article
in
ANALYTICAL CHEMISTRY
2026
2025
A deep learning approach to perform defect classification of freeze-dried product
Quentin Hervé
Nusret Ipek
Jan Verwaeren
Thomas De Beer
A1
Journal Article
in
INTERNATIONAL JOURNAL OF PHARMACEUTICS
2025
Comparative analysis of tablet dissolution behavior : batch vs. continuous direct compression
Kensaku Matsunami
Alexander Ryckaert
Hanne Verrecas
Ana Filipa Tavares da Silva
Andrew Anderson
Håkan Wikström
Melanie Dumarey
James Mann
Thomas De Beer
Valérie Vanhoorne
et al.
A1
Journal Article
in
INTERNATIONAL JOURNAL OF PHARMACEUTICS
2025
Continuous manufacturing of a topical hydrogel with clobetasol propionate-loaded liposomes using QbD methodology
Tryfon Digkas
Lucia Ruxandra Tefas
Alina Silvia Porfire
Ioan Tomuta
Thomas De Beer
A1
Journal Article
in
INTERNATIONAL JOURNAL OF PHARMACEUTICS
2025
Experimental and modeling-based approaches for mechanistic understanding of pan coating process : a detailed review
Behrad Aminahmadi
Elise Vaes
Filip Willemse
Domenica Braile
Luz Naranjo Gomez
Sune Klint Andersen
Thomas De Beer
Ashish Kumar
A1
Journal Article
in
PHARMACEUTICS
2025
Granulation of a planktonic thermophilic anammox culture enables high rate nitrogen removal from warm nitrogen rich wastewater : a proof of concept
Badri Narayan Ravikumar
Mingsheng Jia
Charlotte Geleyn
Thomas De Beer
Jose Maria Carvajal Arroyo
Ramon Ganigué
A1
Journal Article
in
CHEMICAL ENGINEERING JOURNAL
2025
In-line NIR spectroscopy for comprehensive process understanding of semi-continuous blending in continuous production of low-dose formulations
Louis Bouckaert
Alexander De Man
Lisa De Souter
Fabian Starsich
Bernhard Meir
Sebastian Sowinski
Chris Vervaet
Thomas De Beer
Valérie Vanhoorne
A1
Journal Article
in
INTERNATIONAL JOURNAL OF PHARMACEUTICS
2025
Quality-by-digital-design for the in-process integration of Raman spectroscopy as a PAT tool in continuous manufacturing of pharmaceutical liquids and semi-solids
Tryfon Digkas
Isar Charmchi
Thomas De Beer
Ashish Kumar
A1
Journal Article
in
INTERNATIONAL JOURNAL OF PHARMACEUTICS
2025
The impact of glidant addition on continuous blending of active pharmaceutical ingredients
Tom Verbeek
Alexander De Man
Bernd Van Snick
Martin Otava
Thomas De Beer
Ashish Kumar
Chris Vervaet
Valérie Vanhoorne
U
Journal Article
in
International Journal of Pharmaceutics
2025
Towards the spin freeze drying of cell-based therapies
Gust Nuytten
Thomas De Beer
Dissertation
2025
2024
A framework for the in silico assessment of the robustness of an MPC in a CDC line in function of process variability
Ruben Waeytens
Daan Van Hauwermeiren
Wouter Grymonpré
Ingmar Nopens
Thomas De Beer
A1
Journal Article
in
INTERNATIONAL JOURNAL OF PHARMACEUTICS
2024
Analysis of the effect of formulation properties and process parameters on granule formation in twin-screw wet granulation
Michiel Peeters
Ana Alejandra Barrera Jiménez
Kensaku Matsunami
Michael Ghijs
Eduardo dos Santos Schultz
Mina Roudgar
Tamas Vigh
Fanny Stauffer
Ingmar Nopens
Thomas De Beer
A1
Journal Article
in
INTERNATIONAL JOURNAL OF PHARMACEUTICS
2024
Automated particle inspection of continuously freeze-dried products using computer vision
Quentin Hervé
Nusret Ipek
Jan Verwaeren
Thomas De Beer
A1
Journal Article
in
INTERNATIONAL JOURNAL OF PHARMACEUTICS
2024
CFD-DEM model of a cold plasma assisted fluidized bed powder coating process
Pedro Martin Salvador
R. H. Verschueren
Thomas De Beer
Ashish Kumar
A2
Journal Article
in
FRONTIERS IN CHEMICAL ENGINEERING
2024
Development and evaluation of a continuous spin freeze-drying technology : shedding light on the drying kinetics
Laurens Leys
Thomas De Beer
Chris Vervaet
Dissertation
2024
Evaluating the improvement of blend potency measurements in the feed frame of a rotary tablet press using combined NIR and Raman spectroscopy
Alexander De Man
Lisa De Souter
Zhenqi Shi
Chen Mao
Thomas De Beer
A1
Journal Article
in
ANALYTICAL CHEMISTRY
2024
Hybrid modeling of T-shaped partial least squares regression and transfer learning for formulation and manufacturing process development of new drug products
Keita Yaginuma
Kensaku Matsunami
Laure Descamps
Alexander Ryckaert
Thomas De Beer
A1
Journal Article
in
INTERNATIONAL JOURNAL OF PHARMACEUTICS
2024
Investigating screw-agitator speed ratio impact on feeding performance in pharmaceutical manufacturing using discrete element method
Luz Naranjo Gómez
Kensaku Matsunami
Paul Van Liedekerke
Thomas De Beer
Ashish Kumar
A1
Journal Article
in
SCIENTIFIC REPORTS
2024
Modeling and control of pharmaceutical feeding and blending processes
Ruben Waeytens
Ingmar Nopens
Thomas De Beer
Daan Van Hauwermeiren
Dissertation
2024
Relevance of controlled cooling and freezing phases in T-cell cryopreservation
Gust Nuytten
Bruno De Geest
Thomas De Beer
A1
Journal Article
in
CRYOBIOLOGY
2024
The influence of thermal radiation during microwave-assisted freeze-drying of pharmaceutical unit doses
Frederik Laleman
Frédéric Mathot
Erwan Bourlès
Bernadette Scutellà
Laurent Hansen
Thomas De Beer
A1
Journal Article
in
INTERNATIONAL JOURNAL OF PHARMACEUTICS
2024
2023
A colourful way to unravel the important fluidization-related granule size effect on semi-continuous drying
Tuur Vandeputte
Michael Ghijs
Ingmar Nopens
Thomas De Beer
A1
Journal Article
in
AAPS PHARMSCITECH
2023
A formulation-generic pharmaceutical fluidized bed drying model including granule segregation as a vital component
Tuur Vandeputte
Ingmar Nopens
Thomas De Beer
Michael Ghijs
Dissertation
2023
An extended 3-compartmental model for describing step-change experiments in pharmaceutical twin-screw feeders at different refill regimes
Ruben Waeytens
Lisa De Souter
Wouter Grymonpré
Daan Van Hauwermeiren
Ingmar Nopens
Thomas De Beer
C3
Conference
2023
An in silico framework for the robust tuning of an MPC for a continuous blender in a production line for pharmaceutical oral solid dosages.
Ruben Waeytens
Daan Van Hauwermeiren
Wouter Grymonpré
Ingmar Nopens
Thomas De Beer
C3
Conference
2023
Continuous freeze-drying of messenger RNA lipid nanoparticles enables storage at higher temperatures
Sofie Meulewaeter
Gust Nuytten
Miffy H.Y. Cheng
Stefaan De Smedt
Pieter R. Cullis
Thomas De Beer
Ine Lentacker
Rein Verbeke
A1
Journal Article
in
JOURNAL OF CONTROLLED RELEASE
2023
Continuous tablet manufacturing : experimental and model-based analysis of the twin-screw wet granulation and compression unit operations
Michiel Peeters
Thomas De Beer
Ingmar Nopens
Dissertation
2023
Development of diclofenac sodium 3D printed cylindrical and tubular-shaped tablets through hot melt extrusion and fused deposition modelling techniques
Tryfon Digkas
Alina Porfire
Jeroen Van Renterghem
Aseel Samaro
Gheorghe Borodi
Chris Vervaet
Andrea Gabriela Crișan
Sonia Iurian
Thomas De Beer
Ioan Tomuta
A1
Journal Article
in
PHARMACEUTICALS
2023
Elucidation of granulation mechanisms along the length of the barrel in continuous twin-screw melt granulation
Shana Van de Steene
Jeroen Van Renterghem
Valérie Vanhoorne
Chris Vervaet
Ashish Kumar
Thomas De Beer
A1
Journal Article
in
INTERNATIONAL JOURNAL OF PHARMACEUTICS
2023
Evaluation of a PAT-based in-line control system for a continuous spin freeze-drying process
Laurens Leys
Gust Nuytten
Pieter-Jan Van Bockstal
Thomas De Beer
A1
Journal Article
in
INTERNATIONAL JOURNAL OF PHARMACEUTICS
2023
Evaluation of the influence of material properties and process parameters on granule porosity in twin-screw wet granulation
Michiel Peeters
Ana Alejandra Barrera Jiménez
Kensaku Matsunami
Fanny Stauffer
Ingmar Nopens
Thomas De Beer
A1
Journal Article
in
INTERNATIONAL JOURNAL OF PHARMACEUTICS
2023
Exploring the effect of raw material properties on continuous twin-screw wet granulation manufacturability
Michiel Peeters
Ana Alejandra Barrera Jiménez
Kensaku Matsunami
Daan Van Hauwermeiren
Fanny Stauffer
Lærke Arnfast
Tamas Vigh
Ingmar Nopens
Thomas De Beer
A1
Journal Article
in
INTERNATIONAL JOURNAL OF PHARMACEUTICS
2023
Identification of continuous twin-screw melt granulation mechanisms for different screw configurations, process settings and formulation
Shana Van de Steene
Jeroen Van Renterghem
Valérie Vanhoorne
Chris Vervaet
Ashish Kumar
Thomas De Beer
A1
Journal Article
in
INTERNATIONAL JOURNAL OF PHARMACEUTICS
2023
Linking material properties to 1D-PBM parameters towards a generic model for twin-screw wet granulation
Ana Alejandra Barrera Jiménez
Kensaku Matsunami
Daan Van Hauwermeiren
Michiel Peeters
Fanny Stauffer
Eduardo dos Santos Schultz
Ashish Kumar
Thomas De Beer
Ingmar Nopens
A1
Journal Article
in
CHEMICAL ENGINEERING RESEARCH & DESIGN
2023
Mechanistic modeling of semicontinuous fluidized bed drying of pharmaceutical granules by incorporating single particle and bulk drying kinetics
Tuur Vandeputte
Michael Ghijs
Daan Van Hauwermeiren
Eduardo Dos Santos Schultz
Elisabeth Schäfer
Fanny Stauffer
Thomas De Beer
Ingmar Nopens
A1
Journal Article
in
INTERNATIONAL JOURNAL OF PHARMACEUTICS
2023
Model development and calibration of two-dimensional population balance model for twin-screw wet granulation based on particle size distribution and porosity
Ana Alejandra Barrera Jiménez
Kensaku Matsunami
Michael Ghijs
Daan Van Hauwermeiren
Michiel Peeters
Fanny Stauffer
Thomas De Beer
Ingmar Nopens
A1
Journal Article
in
POWDER TECHNOLOGY
2023
Partial least squares regression to calculate population balance model parameters from material properties in continuous twin-screw wet granulation
Ana Alejandra Barrera Jiménez
Kensaku Matsunami
Daan Van Hauwermeiren
Michiel Peeters
Fanny Stauffer
Eduardo dos Santos Schultz
Ashish Kumar
Thomas De Beer
Ingmar Nopens
A1
Journal Article
in
INTERNATIONAL JOURNAL OF PHARMACEUTICS
2023
Successful batch and continuous lyophilization of mRNA LNP formulations depend on cryoprotectants and ionizable lipids
Alexander Lamoot
Joris Lammens
Emily De Lombaerde
Zifu Zhong
Mark Gontsarik
Yong Chen
Thomas De Beer
Bruno De Geest
A1
Journal Article
in
BIOMATERIALS SCIENCE
2023
T-shaped partial least squares for high-dosed new active pharmaceutical ingredients in continuous twin-screw wet granulation : granule size prediction with limited material information
Kensaku Matsunami
Jonathan Meyer
Martin Rowland
Neil Dawson
Thomas De Beer
Daan Van Hauwermeiren
A1
Journal Article
in
INTERNATIONAL JOURNAL OF PHARMACEUTICS
2023
The application of Near-Infrared Spatially Resolved Spectroscopy in scope of achieving continuous real-time quality monitoring and control of tablets with challenging dimensions
Alexander De Man
Jan-Sebastiaan Uyttersprot
Pierre-François Chavez
Freddy Vandenbroucke
François Bovart
Thomas De Beer
A1
Journal Article
in
INTERNATIONAL JOURNAL OF PHARMACEUTICS
2023
Validation of model-based design of experiments for continuous wet granulation and drying
Kensaku Matsunami
Tuur Vandeputte
Ana Alejandra Barrera Jiménez
Michiel Peeters
Michael Ghijs
Daan Van Hauwermeiren
Fanny Stauffer
Eduardo dos Santos Schultz
Ingmar Nopens
Thomas De Beer
A1
Journal Article
in
INTERNATIONAL JOURNAL OF PHARMACEUTICS
2023
Visualization of the granule temperature using thermal imaging to improve understanding of the granulation mechanism in continuous twin-screw melt granulation
Shana Van de Steene
Jeroen Van Renterghem
Valérie Vanhoorne
Chris Vervaet
Ashish Kumar
Thomas De Beer
A1
Journal Article
in
INTERNATIONAL JOURNAL OF PHARMACEUTICS
2023
2022
An extended 3-compartment model for describing step change experiments in pharmaceutical twin-screw feeders at different refill regimes
Ruben Waeytens
Lisa De Souter
Wouter Grymonpré
Daan Van Hauwermeiren
Ingmar Nopens
Thomas De Beer
A1
Journal Article
in
INTERNATIONAL JOURNAL OF PHARMACEUTICS
2022
An extended 3-compartmental model for describing step-change experiments in pharmaceutical twin-screw feeders at different refill regimes
Ruben Waeytens
Lisa De Souter
Wouter Grymonpré
Daan Van Hauwermeiren
Ingmar Nopens
Thomas De Beer
C3
Conference
2022
Continuous direct compression: development of an empirical predictive model and challenges regarding PAT implementation
Bram Bekaert
B. Van Snick
Kenny Pandelaere
J. Dhondt
G. Di Pretoro
Thomas De Beer
Chris Vervaet
Valérie Vanhoorne
A1
Journal Article
in
INTERNATIONAL JOURNAL OF PHARMACEUTICS-X
2022
Development and characterisation of a continuous freeze-drying technology for unit doses
Joris Lammens
Chris Vervaet
Thomas De Beer
Dissertation
2022
Effect of feed frame on lubricant sensitivity during upscaling from a compaction simulator to a rotary tablet press
Cedrine de Backere
Thomas De Beer
Chris Vervaet
Valérie Vanhoorne
A1
Journal Article
in
INTERNATIONAL JOURNAL OF PHARMACEUTICS
2022
Finite element modeling of powder compaction : mini-tablets in comparison with conventionally sized tablets
Luz Naranjo Gómez
Thomas De Beer
Ashish Kumar
A1
Journal Article
in
PHARMACEUTICAL RESEARCH
2022
Impact of alternative lubricants on process and tablet quality for direct compression
Cedrine de Backere
Julian Quodbach
Thomas De Beer
Chris Vervaet
Valérie Vanhoorne
A1
Journal Article
in
INTERNATIONAL JOURNAL OF PHARMACEUTICS
2022
In-depth analysis of the impacts of material properties on size distributions in continuous twin-screw wet granulation to construct a generic 1D population balance model
Kensaku Matsunami
Ana Alejandra Barrera Jiménez
Michiel Peeters
Daan Van Hauwermeiren
Thomas De Beer
Ingmar Nopens
C3
Conference
2022
In-depth analysis of the long-term processability of materials during continuous feeding
Bram Bekaert
B. Van Snick
K. Pandelaere
J. Dhondt
G. Di Pretoro
Thomas De Beer
Chris Vervaet
Valérie Vanhoorne
A1
Journal Article
in
INTERNATIONAL JOURNAL OF PHARMACEUTICS
2022
Increasing the applicability of population balance models in continuous pharmaceutical twin-screw wet granulation
Ana Alejandra Barrera Jiménez
Ingmar Nopens
Thomas De Beer
Daan Van Hauwermeiren
Dissertation
2022
Model-based design of experiments in drug product development in continuous manufacturing
Tuur Vandeputte
Ana Alejandra Barrera Jiménez
Kensaku Matsunami
Michiel Peeters
Michael Ghijs
Daan Van Hauwermeiren
Ingmar Nopens
Thomas De Beer
C3
Conference
2022
Model-based determination of spatial heterogeneities in a pharmaceutical fluidization process and integration into a mechanistic multi-level drying model
Tuur Vandeputte
Michael Ghijs
Miguel Daza
Thomas De Beer
Usman Rehman
Ingmar Nopens
C3
Conference
2022
The effect of binder types on the breakage and drying behavior of granules in a semi-continuous fluid bed dryer after twin screw wet granulation
Lise Vandevivere
Phaedra Denduyver
Christoph Portier
O. Häusler
Thomas De Beer
Chris Vervaet
Valérie Vanhoorne
A1
Journal Article
in
INTERNATIONAL JOURNAL OF PHARMACEUTICS
2022
Towards a generic population balance model for twin-screw wet granulation : from material properties to particle size distribution
Ana Alejandra Barrera Jiménez
Daan Van Hauwermeiren
Kensaku Matsunami
Michiel Peeters
Thomas De Beer
Ingmar Nopens
C3
Conference
2022
Two-dimensional granule property measurement using hyperspectral imaging in continuous pharmaceutical wet granulation
Michael Ghijs
Tuur Vandeputte
Michiel Peeters
Thomas De Beer
Ingmar Nopens
C3
Conference
2022
Two-dimensional population balance model for twin-screw wet granulation : model development and calibration based on particle size distribution and porosity
Kensaku Matsunami
Ana Alejandra Barrera Jiménez
Michiel Peeters
Michael Ghijs
Daan Van Hauwermeiren
Thomas De Beer
Ingmar Nopens
C3
Conference
2022
2021
A NIR-based study of desorption kinetics during continuous spin freeze-drying
Laurens Leys
Gust Nuytten
Joris Lammens
Pieter-Jan Van Bockstal
Jos Corver
Chris Vervaet
Thomas De Beer
A1
Journal Article
in
PHARMACEUTICS
2021
A predictive tableting platform for direct compression processes
Jens Dhondt
Thomas De Beer
Didier Klingeleers
Dissertation
2021
Analysis of fluidization and particle temperature in semicontinuous fluid bed drying of pharmaceutical granules
Tuur Vandeputte
Michael Ghijs
Thomas De Beer
Ingmar Nopens
C3
Conference
2021
Analysis of the effects of process parameters on start-up operation in continuous wet granulation
Kensaku Matsunami
Alexander Ryckaert
Michiel Peeters
Sara Badr
Hirokazu Sugiyama
Ingmar Nopens
Thomas De Beer
A1
Journal Article
in
PROCESSES
2021
Clarifying the formulation effect on the drying behavior of pharmaceutical granules after wet granulation
Tuur Vandeputte
Michael Ghijs
Marie Vandromme
Selien Van Langenhove
Thomas De Beer
Ingmar Nopens
C3
Conference
2021
Continuous granulation
Chris Vervaet
Thomas De Beer
Valérie Vanhoorne
Bookchapter
in
Handbook of pharmaceutical granulation technology
2021
Continuous twin screw granulation : impact of microcrystalline cellulose batch-to-batch variability during granulation and drying : a QbD approach
Christoph Portier
Tamas Vigh
Giustino Di Pretoro
Jan Leys
Didier Klingeleers
Thomas De Beer
Chris Vervaet
Valérie Vanhoorne
A1
Journal Article
in
INTERNATIONAL JOURNAL OF PHARMACEUTICS-X
2021
Determination of a quantitative relationship between material properties, process settings and screw feeding behavior via multivariate data-analysis
Bram Bekaert
L. Penne
W. Grymonpré
B. Van Snick
J. Dhondt
J. Boeckx
J. Vogeleer
Thomas De Beer
Chris Vervaet
Valérie Vanhoorne
A1
Journal Article
in
INTERNATIONAL JOURNAL OF PHARMACEUTICS
2021
Development and application of a mechanistic cooling and freezing model of the spin freezing step within the framework of continuous freeze-drying
Gust Nuytten
Susan Ríos Revatta
Pieter-Jan Van Bockstal
Ashish Kumar
Joris Lammens
Laurens Leys
Brecht Vanbillemont
Jos Corver
Chris Vervaet
Thomas De Beer
A1
Journal Article
in
PHARMACEUTICS
2021
Effect of binder type and lubrication method on the binder efficacy for direct compression
Cedrine de Backere
Thomas De Beer
Chris Vervaet
Valérie Vanhoorne
A1
Journal Article
in
INTERNATIONAL JOURNAL OF PHARMACEUTICS
2021
Evaluation of torque as an in-process control for granule size during twin-screw wet granulation
Alexander Ryckaert
Fanny Stauffer
A. Funke
D. Djuric
Valérie Vanhoorne
Chris Vervaet
Thomas De Beer
A1
Journal Article
in
INTERNATIONAL JOURNAL OF PHARMACEUTICS
2021
Identifying critical binder attributes to facilitate binder selection for efficient formulation development in a continuous twin screw wet granulation process
Lise Vandevivere
Maxine Vangampelaere
Christoph Portier
Cedrine de Backere
Olaf Häusler
Thomas De Beer
Chris Vervaet
Valérie Vanhoorne
A1
Journal Article
in
PHARMACEUTICS
2021
Improvement of a 1D population balance model for twin-screw wet granulation by using identifiability analysis
Ana Alejandra Barrera Jiménez
Daan Van Hauwermeiren
Michiel Peeters
Thomas De Beer
Ingmar Nopens
A1
Journal Article
in
PHARMACEUTICS
2021
Increasing angiogenesis factors in hypoxic diabetic wound conditions by siRNA delivery : additive effect of LbL-gold nanocarriers and desloratadine-induced lysosomal escape
Elnaz Shaabani Sichani
Maryam Sharifiaghdam
Joris Lammens
Herlinde De Keersmaecker
Chris Vervaet
Thomas De Beer
Elahe Motevaseli
Mohammad Hossein Ghahremani
Parvin Mansouri
Stefaan De Smedt
et al.
A1
Journal Article
in
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
2021
Influence of print settings on the critical quality attributes of extrusion-based 3D-printed caplets : a quality-by-design approach
Silke Henry
Lotte De Wever
Valérie Vanhoorne
Thomas De Beer
Chris Vervaet
A1
Journal Article
in
PHARMACEUTICS
2021
Macrophage reprogramming into a pro-healing phenotype by siRNA delivered with LBL assembled nanocomplexes for wound healing applications
Maryam Sharifiaghdam
Elnaz Shaabani Sichani
Zeynab Sharifiaghdam
Herlinde De Keersmaecker
Bart Lucas
Joris Lammens
Hossein Ghanbari
Ladan Teimoori-Toolabi
Chris Vervaet
Thomas De Beer
et al.
A1
Journal Article
in
NANOSCALE
2021
Melt granulation
Shana Van de Steene
Valérie Vanhoorne
Chris Vervaet
Thomas De Beer
Bookchapter
in
Handbook of pharmaceutical granulation technology
2021
Model-based analysis of breakage in fluid bed drying of continuously produced pharmaceutical wet granules
Michael Ghijs
Tuur Vandeputte
Marie Vandromme
Selien Van Langenhove
Thomas De Beer
Ingmar Nopens
C3
Conference
2021
Particle-scale modeling to understand liquid distribution in twin-screw wet granulation
Ashish Kumar
Stefan Radl
Krist V. Gernaey
Thomas De Beer
Ingmar Nopens
A1
Journal Article
in
PHARMACEUTICS
2021
Spin freezing and its impact on pore size, tortuosity and solid state
Joris Lammens
Niloofar Moazami Goudarzi
Laurens Leys
Gust Nuytten
Pieter-Jan Van Bockstal
Chris Vervaet
Matthieu Boone
Thomas De Beer
A1
Journal Article
in
PHARMACEUTICS
2021
The influence of equipment design and process parameters on granule breakage in a semi-continuous fluid bed dryer after continuous twin-screw wet granulation
Alexander Ryckaert
Michael Ghijs
Christoph Portier
Dejan Djuric
Adrian Funke
Chris Vervaet
Thomas De Beer
A1
Journal Article
in
PHARMACEUTICS
2021
Towards an enhanced process understanding for a continuous pharmaceutical manufacturing process of tablets based on twin-screw wet granulation
Alexander Ryckaert
Thomas De Beer
Dissertation
2021
TPLS as predictive platform for twin-screw wet granulation process and formulation development
Alexander Ryckaert
Daan Van Hauwermeiren
Jens Dhondt
Alexander De Man
Adrian Funke
Dejan Djuric
Chris Vervaet
Ingmar Nopens
Thomas De Beer
A1
Journal Article
in
INTERNATIONAL JOURNAL OF PHARMACEUTICS
2021
Two-dimensional moisture content and size measurement of pharmaceutical granules after fluid bed drying using near-infrared chemical imaging
Michael Ghijs
Brecht Vanbillemont
Niels Nicolaï
Thomas De Beer
Ingmar Nopens
A1
Journal Article
in
INTERNATIONAL JOURNAL OF PHARMACEUTICS
2021
2020
4D micro-computed X-ray tomography as a tool to determine critical process and product information of spin freeze-dried unit doses
Brecht Vanbillemont
Joris Lammens
Wannes Goethals
Chris Vervaet
Matthieu Boone
Thomas De Beer
A1
Journal Article
in
PHARMACEUTICS
2020
A primary drying model-based comparison of conventional batch freeze-drying to continuous spin-freeze-drying for unit doses
Laurens Leys
Brecht Vanbillemont
Pieter-Jan Van Bockstal
Joris Lammens
Gust Nuytten
Jos Corver
Chris Vervaet
Thomas De Beer
A1
Journal Article
in
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
2020
Application of polyvinyl acetate in an innovative formulation strategy for lyophilized orally disintegrating tablets
Brecht Vanbillemont
Thomas De Beer
A1
Journal Article
in
INTERNATIONAL JOURNAL OF PHARMACEUTICS
2020
Continuous twin screw granulation : a complex interplay between formulation properties, process settings and screw design
Christoph Portier
Kenny Pandelaere
Urbain Delaet
Tamas Vigh
Giustino Di Pretoro
Thomas De Beer
Chris Vervaet
Valérie Vanhoorne
A1
Journal Article
in
INTERNATIONAL JOURNAL OF PHARMACEUTICS
2020
Continuous twin screw granulation : impact of binder addition method and surfactants on granulation of a high-dosed, poorly soluble API
Christoph Portier
Tamas Vigh
Giustino Di Pretoro
Thomas De Beer
Chris Vervaet
Valérie Vanhoorne
A1
Journal Article
in
INTERNATIONAL JOURNAL OF PHARMACEUTICS
2020
Continuous twin screw granulation : influence of process and formulation variables on granule quality attributes of model formulations
Christoph Portier
Kenny Pandelaere
Urbain Delaet
Tamas Vigh
Ashish Kumar
Giustino Di Pretoro
Thomas De Beer
Chris Vervaet
Valérie Vanhoorne
A1
Journal Article
in
INTERNATIONAL JOURNAL OF PHARMACEUTICS
2020
Continuous twin screw granulation : robustness of lactose/MCC-based formulations
Christoph Portier
Charlotte De Vriendt
Tamas Vigh
Giustino Di Pretoro
Thomas De Beer
Chris Vervaet
Valérie Vanhoorne
A1
Journal Article
in
INTERNATIONAL JOURNAL OF PHARMACEUTICS
2020
Delta-mannitol to enable continuous twin-screw granulation of a highly dosed, poorly compactable formulation
Valérie Vanhoorne
Ruben Almey
Thomas De Beer
Chris Vervaet
A1
Journal Article
in
INTERNATIONAL JOURNAL OF PHARMACEUTICS
2020
Development and evaluation of next-generation pharmaceutical freeze-drying technologies
Brecht Vanbillemont
Thomas De Beer
Dissertation
2020
Evaluation of an external lubrication system implemented in a compaction simulator
Cedrine de Backere
Thomas De Beer
Chris Vervaet
Valérie Vanhoorne
A1
Journal Article
in
INTERNATIONAL JOURNAL OF PHARMACEUTICS
2020
Exploring printed drug formulations for inkjet and stencil printing
Henrika Wickström
Thomas De Beer
Niklas O. Sandler
Dissertation
2020
In-line temperature measurement to improve the understanding of the wetting phase in twin-screw wet granulation and its use in process development
Fanny Stauffer
Alexander Ryckaert
Valérie Vanhoorne
Daan Van Hauwermeiren
Adrian Funke
Dejan Djuric
Chris Vervaet
Ingmar Nopens
Thomas De Beer
A1
Journal Article
in
INTERNATIONAL JOURNAL OF PHARMACEUTICS
2020
In-situ X-ray imaging of sublimating spin-frozen solutions
Wannes Goethals
Brecht Vanbillemont
Joris Lammens
Thomas De Beer
Chris Vervaet
Matthieu Boone
A1
Journal Article
in
MATERIALS
2020
Influence of binder attributes on binder effectiveness in a continuous twin screw wet granulation process via wet and dry binder addition
Lise Vandevivere
Phaedra Denduyver
Christoph Portier
Olaf Häusler
Thomas De Beer
Chris Vervaet
Valérie Vanhoorne
A1
Journal Article
in
INTERNATIONAL JOURNAL OF PHARMACEUTICS
2020
Lyophilization and nebulization of pulmonary surfactant-coated nanogels for siRNA inhalation therapy
Pieterjan Merckx
Joris Lammens
Gust Nuytten
Bram Bogaert
Roberta Guagliardo
Tania Maes
Chris Vervaet
Thomas De Beer
Stefaan De Smedt
Koen Raemdonck
A1
Journal Article
in
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
2020
Model-based optimisation and control strategy for the primary drying phase of a lyophilisation process
Brecht Vanbillemont
Niels Nicolaï
Laurens Leys
Thomas De Beer
A1
Journal Article
in
PHARMACEUTICS
2020
Model-based optimization of the primary drying phase of oral lyophilizates
Brecht Vanbillemont
Thomas De Beer
A1
Journal Article
in
INTERNATIONAL JOURNAL OF PHARMACEUTICS-X
2020
Modelling and experimentation on fluid bed drying of granules in the context of pharmaceutical continuous wet granulation
Michael Ghijs
Ingmar Nopens
Thomas De Beer
Dissertation
2020
New advances in the characterization of lyophilised orally disintegrating tablets
Brecht Vanbillemont
Hannelien Everaert
Thomas De Beer
A1
Journal Article
in
INTERNATIONAL JOURNAL OF PHARMACEUTICS
2020
On the simulation of particle size distributions in continuous pharmaceutical wet granulation
Daan Van Hauwermeiren
Ingmar Nopens
Thomas De Beer
Dissertation
2020
Predicting pharmaceutical particle size distributions using kernel mean embedding
Daan Van Hauwermeiren
Michiel Stock
Thomas De Beer
Ingmar Nopens
A1
Journal Article
in
PHARMACEUTICS
2020
Prilling of API/fatty acid suspensions : screening of additives for drug release modification
Elien De Coninck
Valérie Vanhoorne
Matthieu Boone
G Van Assche
Bruno De Geest
Thomas De Beer
Chris Vervaet
A1
Journal Article
in
INTERNATIONAL JOURNAL OF PHARMACEUTICS
2020
Quality by design for pharmaceutical hot melt extrusion via rheology and process analytical technology
Jeroen Van Renterghem
Thomas De Beer
Chris Vervaet
Dissertation
2020
Screening of pharmaceutical polymers for Extrusion-Based Additive Manufacturing of patient-tailored tablets
Aseel Samaro
Pauline Janssens
Valérie Vanhoorne
Jeroen Van Renterghem
Mia Eeckhout
Ludwig Cardon
Thomas De Beer
Chris Vervaet
A1
Journal Article
in
INTERNATIONAL JOURNAL OF PHARMACEUTICS
2020
Surface functionalization with polyethylene glycol and polyethyleneimine improves the performance of graphene-based materials for safe and efficient intracellular delivery by laser-induced photoporation
Jing Liu
Chengnan Li
Toon Brans
Aranit Harizaj
Shana Van de Steene
Thomas De Beer
Stefaan De Smedt
Sabine Szunerits
Rabah Boukherroub
Ranhua Xiong
et al.
A1
Journal Article
in
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
2020
The impact of formulation composition and process settings of traditional batch versus continuous freeze-drying on protein aggregation
Brecht Vanbillemont
John F. Carpenter
Christine Probst
Thomas De Beer
A1
Journal Article
in
JOURNAL OF PHARMACEUTICAL SCIENCES
2020
Viscosity of API/fatty acid suspensions : pitfalls during analysis
Elien De Coninck
Flavio H. Marchesini
Valérie Vanhoorne
Thomas De Beer
Chris Vervaet
A1
Journal Article
in
INTERNATIONAL JOURNAL OF PHARMACEUTICS
2020
2019
A model predictive control strategy of the dynamic primary drying settings for a batch freeze-drying process
Brecht Vanbillemont
Niels Nicolaï
Laurens Leys
Thomas De Beer
C3
Conference
2019
A multivariate approach to predict the volumetric and gravimetric feeding behavior of a low feed rate feeder based on raw material properties
Nils Bostijn
Jens Dhondt
Alexander Ryckaert
Edina Szabó
W Dhondt
Bernd Van Snick
Valérie Vanhoorne
Chris Vervaet
Thomas De Beer
A1
Journal Article
in
INTERNATIONAL JOURNAL OF PHARMACEUTICS
2019
A Quality by Design strategy for a continuous pharmaceutical manufacturing process of tablets based on wet granulation
Fien De Leersnyder
Thomas De Beer
Eric Ziemons
Dissertation
2019
Analysis of a pharmaceutical batch freeze dryer : resource consumption, hotspots, and factors for potential improvement
Gabriela Rentería Gámiz
Pieter-Jan Van Bockstal
Steven De Meester
Thomas De Beer
Jos Corver
Jo Dewulf
A1
Journal Article
in
DRYING TECHNOLOGY
2019
Assessment of volumetric scale-up law for processing of a sustained release formulation on co-rotating hot-melt extruders
Jeroen Van Renterghem
Shana Van de Steene
Tryfon Digkas
Margarethe Richter
Chris Vervaet
Thomas De Beer
A1
Journal Article
in
INTERNATIONAL JOURNAL OF PHARMACEUTICS
2019
Continuous manufacturing of a pharmaceutical cream : investigating continuous powder dispersing and residence time distribution (RTD)
Nils Bostijn
Jeroen Van Renterghem
Brecht Vanbillemont
W Dhondt
Chris Vervaet
Thomas De Beer
A1
Journal Article
in
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
2019
Development of PAT methodologies and continuous manufacturing technology for pharmaceutical semi-solid and liquid formulations
Nils Bostijn
Thomas De Beer
Dissertation
2019
Dual chamber cartridges in a continuous pharmaceutical freeze-drying concept : determination of the optimal dynamic infrared heater temperature during primary drying
Laurens De Meyer
Joris Lammens
Brecht Vanbillemont
Pieter-Jan Van Bockstal
Jos Corver
Chris Vervaet
Wolfgang Friess
Thomas De Beer
A1
Journal Article
in
INTERNATIONAL JOURNAL OF PHARMACEUTICS
2019
Dynamic flowsheet model development and sensitivity analysis of a continuous pharmaceutical tablet manufacturing process using the wet granulation route
Nirupaplava Metta
Michael Ghijs
Elisabeth Schäfer
Ashish Kumar
Philippe Cappuyns
Ivo Van Assche
Ravendra Singh
Rohit Ramachandran
Thomas De Beer
Marianthi Ierapetritou
et al.
A1
Journal Article
in
PROCESSES
2019
Evaluation of an in-line NIR spectroscopic method for the determination of the residence time in a tablet press
Fien De Leersnyder
Valérie Vanhoorne
Ashish Kumar
Chris Vervaet
Thomas De Beer
A1
Journal Article
in
INTERNATIONAL JOURNAL OF PHARMACEUTICS
2019
Flowsheet modeling of the compression step of a continuous wet granulation production line
Brecht Vanbillemont
Michael Ghijs
Manuel Sebastian Escotet-Espinoza
Philippe Cappuyns
Ivo Van Assche
Fernando J Muzzio
Ingmar Nopens
Thomas De Beer
C3
Conference
2019
Heat transfer evaluation during twin-screw wet granulation in view of detailed process understanding
Fanny Stauffer
Alexander Ryckaert
Daan Van Hauwermeiren
Adrian Funke
Dejan Djuric
Ingmar Nopens
Thomas De Beer
A1
Journal Article
in
AAPS PHARMSCITECH
2019
Impact of material properties and process variables on the residence time distribution in twin screw feeding equipment
Bernd Van Snick
Ashish Kumar
Maxim Verstraeten
Kenny Pandelaere
Jens Dhondt
G Di Pretoro
Thomas De Beer
Chris Vervaet
Valérie Vanhoorne
A1
Journal Article
in
INTERNATIONAL JOURNAL OF PHARMACEUTICS
2019
Improved label-free identification of individual exosome-like vesicles with Au@Ag nanoparticles as SERS substrate
Juan Fraire
Stephan Stremersch
Davinia Bouckaert
Tinne Monteyne
Thomas De Beer
Pieter Wuytens
Riet De Rycke
Andre Skirtach
Koen Raemdonck
Stefaan De Smedt
et al.
A1
Journal Article
in
ACS APPLIED MATERIALS & INTERFACES
2019
In-depth evaluation of data collected during a continuous pharmaceutical manufacturing process : a multivariate statistical process monitoring approach
Ana Filipa Costa da Silva
Jurgen Vercruysse
Chris Vervaet
Jean Paul Remon
João A. Lopes
Thomas De Beer
Mafalda C. Sarraguça
A1
Journal Article
in
JOURNAL OF PHARMACEUTICAL SCIENCES
2019
Kernel mean embedding of distributions : a new data-driven model approach for modelling a continuous pharmaceutical twin-screw granulation process
Daan Van Hauwermeiren
Michiel Stock
Thomas De Beer
Ingmar Nopens
C3
Conference
2019
Managing active pharmaceutical ingredient raw material variability during twin-screw blend feeding
Fanny Stauffer
Valérie Vanhoorne
G Pilcer
P-F Chavez
MA Schubert
Chris Vervaet
Thomas De Beer
A1
Journal Article
in
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
2019
Managing API raw material variability during continuous twin-screw wet granulation
Fanny Stauffer
Valérie Vanhoorne
G Pilcer
Pierre-François Chavez
Chris Vervaet
Thomas De Beer
A1
Journal Article
in
INTERNATIONAL JOURNAL OF PHARMACEUTICS
2019
Managing API raw material variability in a continuous manufacturing line : prediction of process robustness
Fanny Stauffer
Valérie Vanhoorne
G Pilcer
Pierre-François Chavez
Chris Vervaet
Thomas De Beer
A1
Journal Article
in
INTERNATIONAL JOURNAL OF PHARMACEUTICS
2019
Managing raw material variability in continuous manufacturing based on twin-screw granulation
Fanny Stauffer
Thomas De Beer
Dissertation
2019
Modeling of semicontinuous fluid bed drying of pharmaceutical granules with respect to granule size
Michael Ghijs
Elisabeth Schäfer
Ashish Kumar
Philippe Cappuyns
Ivo Van Assche
Fien De Leersnyder
Valérie Vanhoorne
Thomas De Beer
Ingmar Nopens
A1
Journal Article
in
JOURNAL OF PHARMACEUTICAL SCIENCES
2019
Native starch as in situ binder for continuous twin screw wet granulation
Lise Vandevivere
Christoph Portier
Valérie Vanhoorne
Olaf Häusler
Denis Simon
Thomas De Beer
Chris Vervaet
A1
Journal Article
in
INTERNATIONAL JOURNAL OF PHARMACEUTICS
2019
On the modelling of granule size distributions in twin-screw wet granulation : calibration of a novel compartmental population balance model
Daan Van Hauwermeiren
Maxim Verstraeten
Pankaj Doshi
Mary T am Ende
Neil Turnbull
Kai Lee
Thomas De Beer
Ingmar Nopens
A1
Journal Article
in
POWDER TECHNOLOGY
2019
PAT-based batch statistical process control of a manufacturing process for a pharmaceutical ointment
Nils Bostijn
W. Dhondt
Chris Vervaet
Thomas De Beer
A1
Journal Article
in
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
2019
Population balance modelling for twin-screw wet granulation : insight in the notion of distance between distributions and the need for identifiable models for good model predictive power
Daan Van Hauwermeiren
Ingmar Nopens
Thomas De Beer
C3
Conference
2019
Prilling of API/fatty acid suspensions : processability and characterisation
Elien De Coninck
Valérie Vanhoorne
Ahmed Elmahdy
Matthieu Boone
G Van Assche
D Markl
Bruno De Geest
Thomas De Beer
Chris Vervaet
A1
Journal Article
in
INTERNATIONAL JOURNAL OF PHARMACEUTICS
2019
Process control levels for continuous pharmaceutical tablet manufacturing
Niels Nicolaï
Ingmar Nopens
Maxim Verstraeten
Thomas De Beer
Bookchapter
in
Chemical engineering in the pharmaceutical industry : drug product design, development, and modeling
2019
Realisation and evaluation of an innovative continuous freeze-drying technology for (bio-)pharmaceutical cylindrical unit doses
Laurens De Meyer
Thomas De Beer
Dissertation
2019
Supervisory process monitoring, identification and control for continuous pharmaceutical wet granulation
Niels Nicolaï
Ingmar Nopens
Thomas De Beer
Krist V Gernaey
Dissertation
2019
The generation and use of recombinant extracellular vesicles as biological reference material
Edward Geeurickx
Joeri Tulkens
Bert Dhondt
Jan Van Deun
Lien Lippens
Glenn Vergauwen
Elisa Heyrman
Delphine De Sutter
Kris Gevaert
Francis Impens
et al.
A1
Journal Article
in
NATURE COMMUNICATIONS
2019
Towards a generic model for twin-screw wet granulation
Daan Van Hauwermeiren
Maxim Verstraeten
Michael Ghijs
Kai Lee
Neil Turnbull
Mary T am Ende
Pankaj Doshi
David Wilson
Thomas De Beer
Ingmar Nopens
Bookchapter
in
Chemical engineering in the pharmaceutical industry : drug product design, development, and modeling
2019
Two-compartment modeling and dynamics of top-sprayed fluidized bed granulator
Gurmeet Kaur
Mehakpreet Singh
Themis Matsoukas
Jitendra Kumar
Thomas De Beer
Ingmar Nopens
A1
Journal Article
in
APPLIED MATHEMATICAL MODELLING
2019
2018
A comparative study of numerical approximations for solving the Smoluchowski coagulation equation
Mehakpreet Singh
G Kaur
J Kumar
Thomas De Beer
Ingmar Nopens
A1
Journal Article
in
BRAZILIAN JOURNAL OF CHEMICAL ENGINEERING
2018
A continuous manufacturing concept for a pharmaceutical oral suspension
Nils Bostijn
Jeroen Van Renterghem
W. Dhondt
Chris Vervaet
Thomas De Beer
A1
Journal Article
in
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
2018
A model predictive control strategy of the dynamic primary drying settings for a batch freeze drying process
Brecht Vanbillemont
Niels Nicolaï
Jos Corver
Thomas De Beer
C3
Conference
2018
A multivariate raw material property database to facilitate drug product development and enable in-silico design of pharmaceutical dry powder processes
Bernd Van Snick
Jens Dhondt
Kenny Pandelaere
Johny Bertels
Roel Mertens
Didier Klingeleers
Giustino Di Pretoro
Jean Paul Remon
Chris Vervaet
Thomas De Beer
et al.
A1
Journal Article
in
INTERNATIONAL JOURNAL OF PHARMACEUTICS
2018
A novel approach to support formulation design on twin screw wet granulation technology : understanding the impact of overarching excipient properties on drug product quality attributes
Nina Willecke
A Szepes
M Wunderlich
Jean Paul Remon
Chris Vervaet
Thomas De Beer
A1
Journal Article
in
INTERNATIONAL JOURNAL OF PHARMACEUTICS
2018
Analysis of protein glycation in human fingernail clippings with near-infrared (NIR) spectroscopy as an alternative technique for the diagnosis of diabetes mellitus
Tinne Monteyne
Renaat Coopman
Antoine S Kishabongo
Jonas Himpe
Bruno Lapauw
Samiah Shadid
Elisabeth H Van Aken
Darja Berenson
Marijn Speeckaert
Thomas De Beer
et al.
A1
Journal Article
in
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
2018
Breakage and drying behaviour of granules in a continuous fluid bed dryer : influence of process parameters and wet granule transfer
Fien De Leersnyder
Valérie Vanhoorne
H Bekaert
Jurgen Vercruysse
Michael Ghijs
Nils Bostijn
Maxim Verstraeten
P Cappuyns
I Van Assche
Y Vander Heyden
et al.
A1
Journal Article
in
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
2018
Control of three different continuous pharmaceutical manufacturing processes : use of soft sensors
Jakob Rehrl
Anssi-Pekka Karttunen
Niels Nicolaï
Theresa Hoermann
Martin Horn
Ossi Korhonen
Ingmar Nopens
Thomas De Beer
Johannes G Khinast
A1
Journal Article
in
INTERNATIONAL JOURNAL OF PHARMACEUTICS
2018
Developing a framework to model the primary drying step of a continuous freeze-drying process based on infrared radiation
Pieter-Jan Van Bockstal
Jos Corver
Séverine Mortier
Laurens De Meyer
Ingmar Nopens
Krist V Gernaey
Thomas De Beer
A1
Journal Article
in
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
2018
Development and validation of an in-line NIR spectroscopic method for continuous blend potency determination in the feed frame of a tablet press
Fien De Leersnyder
Elisabeth Peeters
Hasna Djalabi
Valérie Vanhoorne
Bernd Van Snick
Ke Hong
Stephen Hammond
Angela Yang Liu
Eric Ziemons
Chris Vervaet
et al.
A1
Journal Article
in
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
2018
Downscaling of the tableting process : feasibility of miniaturized forced feeders on a high-speed rotary tablet press
Wouter Grymonpré
Barbora Blahova Prudilova
Valérie Vanhoorne
Bernd Van Snick
Frederik Detobel
Jean Paul Remon
Thomas De Beer
Chris Vervaet
A1
Journal Article
in
INTERNATIONAL JOURNAL OF PHARMACEUTICS
2018
Downstream processing from melt granulation towards tablets : in-depth analysis of a continuous twin-screw melt granulation process using polymeric binders
Wouter Grymonpré
Glenn Verstraete
Valérie Vanhoorne
Jean Paul Remon
Thomas De Beer
Chris Vervaet
A1
Journal Article
in
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
2018
Formulation design for continuous twin screw wet granulation
Nina Willecke
Chris Vervaet
Thomas De Beer
Anikó Szepes
Martin Wunderlich
Dissertation
2018
Global Sensitivity Analysis as Good Modelling Practices tool for the identification of the most influential process parameters of the primary drying step during freeze-drying
Pieter-Jan Van Bockstal
Séverine Mortier
Jos Corver
Ingmar Nopens
Krist V Gernaey
Thomas De Beer
A1
Journal Article
in
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
2018
Impact of blend properties on die filling during tableting
Bernd Van Snick
Wouter Grymonpré
Jens Dhondt
Kenny Pandelaere
G Di Pretoro
Jean Paul Remon
Thomas De Beer
Chris Vervaet
Valérie Vanhoorne
A1
Journal Article
in
INTERNATIONAL JOURNAL OF PHARMACEUTICS
2018
In-line UV spectroscopy for the quantification of low-dose active ingredients during the manufacturing of pharmaceutical semi-solid and liquid formulations
Nils Bostijn
M Hellings
M Van Der Veen
Chris Vervaet
Thomas De Beer
A1
Journal Article
in
ANALYTICA CHIMICA ACTA
2018
Influence of extended dwell time during pre- and main compression on the properties of ibuprofen tablets
Elisabeth Peeters
Ana Tavares da Silva
Margot Fonteyne
Thomas De Beer
Chris Vervaet
Jean Paul Remon
A1
Journal Article
in
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
2018
Liquid-to-solid ratio control as an advanced process control solution for continuous twin-screw wet granulation
Niels Nicolaï
Fien De Leersnyder
Dana Copot
Michiel Stock
Clara-Mihaela Ionescu
Krist V Gernaey
Ingmar Nopens
Thomas De Beer
A1
Journal Article
in
AICHE JOURNAL
2018
Mathematical modelling and simulation of a spray fluidized bed granulator
Gurmeet Kaur
Mehakpreet Singh
Jitendra Kumar
Thomas De Beer
Ingmar Nopens
A1
Journal Article
in
PROCESSES
2018
Model development and prediction of particle size distribution, density and friability of a comilling operation in a continuous pharmaceutical manufacturing process
Nirupaplava Metta
Maxim Verstraeten
Michael Ghijs
Ashish Kumar
Elisabeth Schafer
Ravendra Singh
Thomas De Beer
Ingmar Nopens
Philippe Cappuyns
Ivo Van Assche
et al.
A1
Journal Article
in
INTERNATIONAL JOURNAL OF PHARMACEUTICS
2018
Model-based NIR spectroscopy implementation for in-line assay monitoring during a pharmaceutical suspension manufacturing process
Maxim Verstraeten
Daan Van Hauwermeiren
Mario Hellings
Eline Hermans
Jeroen Geens
Chris Vervaet
Ingmar Nopens
Thomas De Beer
A1
Journal Article
in
INTERNATIONAL JOURNAL OF PHARMACEUTICS
2018
Model-based process analytical technology in continuous manufacturing
Maxim Verstraeten
Thomas De Beer
Dissertation
2018
On the identifiability of kernels for Population Balance Modelling
Daan Van Hauwermeiren
Thomas De Beer
Ingmar Nopens
C3
Conference
2018
Optimizing feed frame design and tableting process parameters to increase die-filling uniformity on a high-speed rotary tablet press
Wouter Grymonpré
Valérie Vanhoorne
Bernd Van Snick
Barbora Blahova Prudilova
Frederik Detobel
Jean Paul Remon
Thomas De Beer
Chris Vervaet
A1
Journal Article
in
INTERNATIONAL JOURNAL OF PHARMACEUTICS
2018
Potential of near-infrared chemical imaging as process analytical technology tool for continuous freeze-drying
Davinia Brouckaert
Laurens De Meyer
Brecht Vanbillemont
Pieter-Jan Van Bockstal
Joris Lammens
Séverine Mortier
Jos Corver
Chris Vervaet
Ingmar Nopens
Thomas De Beer
A1
Journal Article
in
ANALYTICAL CHEMISTRY
2018
Process monitoring and evaluation of a continuous pharmaceutical twin-screw granulation and drying process using multivariate data analysis
Antonio Pires da Silva Baptista
Jurgen Vercruysse
Chris Vervaet
Jean Paul Remon
J.A. Lopes
Thomas De Beer
M.C. Sarraguça
A1
Journal Article
in
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
2018
Pure breakage PBM calibration in pharmaceutical wet granulation
Michael Ghijs
Elisabeth Schäfer
Ashish Kumar
Philippe Cappuyns
Ivo Van Assche
Thomas De Beer
Ingmar Nopens
C3
Conference
2018
Raw material variability of an active pharmaceutical ingredient and its relevance for processability in secondary continuous pharmaceutical manufacturing
Fanny Stauffer
Valérie Vanhoorne
G Pilcer
P-F Chavez
S Rome
MA Schubert
L Aerts
Thomas De Beer
A1
Journal Article
in
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
2018
Recombinant extracellular vesicles : biological reference material to standardize extracellular vesicle research
Edward Geeurickx
Elisa Heyrman
Jan Van Deun
Lien Lippens
Joeri Tulkens
Bert Dhondt
Glenn Vergauwen
Kris Gevaert
Francis Impens
Ilkka Miinalainen
et al.
C3
Conference
2018
Recombinant extracellular vesicles : biological reference material to standardize extracellular vesicle research
Edward Geeurickx
Elisa Heyrman
Jan Van Deun
Lien Lippens
Joeri Tulkens
Bert Dhondt
Glenn Vergauwen
Kris Gevaert
Francis Impens
Ilkka Miinalainen
et al.
C3
Conference
2018
Solution of bivariate aggregation population balance equation : a comparative study
Mehakpreet Singh
Gurmeet Kaur
Thomas De Beer
Ingmar Nopens
A1
Journal Article
in
REACTION KINETICS MECHANISMS AND CATALYSIS
2018
The development of a continuous and controlled freeze-drying concept for biopharmaceutical unit doses
Pieter-Jan Van Bockstal
Thomas De Beer
Dissertation
2018
The impact of the injection mold temperature upon polymer crystallization and resulting drug release from immediate and sustained release tablets
Jeroen Van Renterghem
Heleen Dhondt
Glenn Verstraete
Michiel De Bruyne
Chris Vervaet
Thomas De Beer
A1
Journal Article
in
INTERNATIONAL JOURNAL OF PHARMACEUTICS
2018
The relevance of shear, sedimentation and diffusion during spin freezing, as potential first step of a continuous freeze-drying process for unit doses
Joris Lammens
Séverine Mortier
Laurens De Meyer
Brecht Vanbillemont
Pieter-Jan Van Bockstal
Simon Van Herck
Jos Corver
Ingmar Nopens
Valérie Vanhoorne
Bruno De Geest
et al.
A1
Journal Article
in
INTERNATIONAL JOURNAL OF PHARMACEUTICS
2018
Thermal imaging as a noncontact inline process analytical tool for product temperature monitoring during continuous freeze-drying of unit doses
Pieter-Jan Van Bockstal
Jos Corver
Laurens De Meyer
Chris Vervaet
Thomas De Beer
A1
Journal Article
in
ANALYTICAL CHEMISTRY
2018
2017
Advanced process control practices for continuous pharmaceutical twin-screw wet granulation
Niels Nicolaï
Ingmar Nopens
Krist V Gernaey
Thomas De Beer
C3
Conference
2017
Applying inline spatial filter velocimetry to improve process robustness of a continuous twin-screw wet granulator
Niels Nicolaï
Ingmar Nopens
Krist V Gernaey
Thomas De Beer
C3
Conference
2017
Continuous direct compression as manufacturing platform for sustained release tablets
Bernd Van Snick
J. Holman
C. Cunningham
Ashish Kumar
Jurgen Vercruysse
Thomas De Beer
Jean Paul Remon
Chris Vervaet
A1
Journal Article
in
INTERNATIONAL JOURNAL OF PHARMACEUTICS
2017
Development of a continuous direct compression platform for low-dose drug products
Bernd Van Snick
J. Holman
Valérie Vanhoorne
Ashish Kumar
Thomas De Beer
Jean Paul Remon
Chris Vervaet
A1
Journal Article
in
INTERNATIONAL JOURNAL OF PHARMACEUTICS
2017
Downstream processing from hot-melt extrusion towards tablets : a quality by design approach
Wouter Grymonpré
Nils Bostijn
Simon Van Herck
Glenn Verstraete
Valérie Vanhoorne
Lutz Nuhn
Pieter Rombouts
Thomas De Beer
Jean Paul Remon
Chris Vervaet
A1
Journal Article
in
INTERNATIONAL JOURNAL OF PHARMACEUTICS
2017
Elucidation and visualization of solid-state transformation and mixing in a pharmaceutical mini hot melt extrusion process using in-line Raman spectroscopy
Jeroen Van Renterghem
Ashish Kumar
Chris Vervaet
Jean Paul Remon
Ingmar Nopens
Yvan Vander Heyden
Thomas De Beer
A1
Journal Article
in
INTERNATIONAL JOURNAL OF PHARMACEUTICS
2017
Extension of a mechanistic model for drying of single pharmaceutical granules to semi-continuous fluid bed drying
Michael Ghijs
Séverine Mortier
Philippe Cappuyns
Krist V Gernaey
Thomas De Beer
Ingmar Nopens
C3
Conference
2017
Identifying overarching excipient properties towards an in-depth understanding of process and product performance for continuous twin-screw wet granulation
Nina Willecke
A Szepes
M Wunderlich
Jean Paul Remon
Chris Vervaet
Thomas De Beer
A1
Journal Article
in
INTERNATIONAL JOURNAL OF PHARMACEUTICS
2017
Implementation of process analytical technology (PAT) systems in manufacturing processes of liquid formulations
Davinia Brouckaert
Thomas De Beer
Dissertation
2017
In-depth experimental analysis of pharmaceutical twin-screw wet granulation in view of detailed process understanding
Maxim Verstraeten
Daan Van Hauwermeiren
Kai Lee
Neil Turnbull
David Wilsdon
Mary Am Ende
Pankaj Doshi
Chris Vervaet
Davinia Brouckaert
Séverine Mortier
et al.
A1
Journal Article
in
INTERNATIONAL JOURNAL OF PHARMACEUTICS
2017
In-line monitoring of compaction properties on a rotary tablet press during tablet manufacturing of hot-melt extruded amorphous solid dispersions
Wouter Grymonpré
Glenn Verstraete
Pieter-Jan Van Bockstal
Jeroen Van Renterghem
Pieter Rombouts
Thomas De Beer
Jean Paul Remon
Chris Vervaet
A1
Journal Article
in
INTERNATIONAL JOURNAL OF PHARMACEUTICS
2017
Mechanistic modelling of infrared mediated energy transfer during the primary drying step of a continuous freeze-drying process
Pieter-Jan Van Bockstal
Séverine Mortier
Laurens De Meyer
Jos Corver
Chris Vervaet
Ingmar Nopens
Thomas De Beer
A1
Journal Article
in
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
2017
Methodology and pitfalls when calibrating a PBM : the case of twin-screw wet granulation
Daan Van Hauwermeiren
Maxim Verstraeten
Thomas De Beer
Ingmar Nopens
C1
Conference
2017
Methodology and pitfalls when calibrating a PBM : the case of twin-screw wet granulation
Daan Van Hauwermeiren
Maxim Verstraeten
Thomas De Beer
Ingmar Nopens
C1
Conference
2017
Modelling the primary drying step for the determination of the optimal dynamic heating pad temperature in a continuous pharmaceutical freeze-drying process for unit doses
Laurens De Meyer
Joris Lammens
Séverine Mortier
Brecht Vanbillemont
Pieter-Jan Van Bockstal
Jos Corver
Ingmar Nopens
Chris Vervaet
Thomas De Beer
A1
Journal Article
in
INTERNATIONAL JOURNAL OF PHARMACEUTICS
2017
Multivariate statistical process control of a continuous pharmaceutical twin-screw granulation and fluid bed drying process
Ana Tavares da Silva
MC Sarraguça
Margot Fonteyne
Jurgen Vercruysse
Fien De Leersnyder
Valérie Vanhoorne
Nils Bostijn
Maxim Verstraeten
Chris Vervaet
Jean Paul Remon
et al.
A1
Journal Article
in
INTERNATIONAL JOURNAL OF PHARMACEUTICS
2017
Noncontact infrared-mediated heat transfer during continuous freeze-drying of unit doses
Pieter-Jan Van Bockstal
Laurens De Meyer
Jos Corver
Chris Vervaet
Thomas De Beer
A1
Journal Article
in
JOURNAL OF PHARMACEUTICAL SCIENCES
2017
Practical implementation of dynamic primary drying settings in a continuous freeze-drying process
Brecht Vanbillemont
Niels Nicolaï
Pieter-Jan Van Bockstal
Laurens De Meyer
Séverine Mortier
Jos Corver
Chris Vervaet
Thomas De Beer
C3
Conference
2017
Process analytical technology for batch and continuous pharmaceutical processes’ supervision
Ana Tavares da Silva
Thomas De Beer
José Luis Fontes da Costa Lima
João Pedro Martins de Almeida Lopes
Mafalda Sofia Coelho da Cruz Sarraguça
Dissertation
2017
Quantitative risk assessment via uncertainty analysis in combination with error propagation for the determination of the dynamic Design Space of the primary drying step during freeze-drying
Pieter-Jan Van Bockstal
Séverine Mortier
Jos Corver
Ingmar Nopens
Krist V Gernaey
Thomas De Beer
A1
Journal Article
in
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
2017
Rheological characterization of molten polymer-drug dispersions as a predictive tool for pharmaceutical hot-melt extrusion processability
Jeroen Van Renterghem
Chris Vervaet
Thomas De Beer
A1
Journal Article
in
PHARMACEUTICAL RESEARCH
2017
Statistical process control of cocrystallization processes : a comparison between OPLS and PLS
Ana Tavares da Silva
Mafalda Cruz Sarraguça
Paulo R Ribeiro
Adenilson O Santos
Thomas De Beer
João Almeida Lopes
A1
Journal Article
in
INTERNATIONAL JOURNAL OF PHARMACEUTICS
2017
The use of partially hydrolysed polyvinyl alcohol for the production of high drug-loaded sustained release pellets via extrusion-spheronisation and coating : in vitro and in vivo evaluation
Glenn Verstraete
Wesley De Jaeghere
J Vercruysse
Wouter Grymonpré
Valérie Vanhoorne
Fanny Stauffer
Thomas De Beer
Adam Bezuijen
Jean Paul Remon
Chris Vervaet
A1
Journal Article
in
INTERNATIONAL JOURNAL OF PHARMACEUTICS
2017
Thermoplastic polyurethane-based intravaginal rings for prophylaxis and treatment of (recurrent) bacterial vaginosis
Glenn Verstraete
L. Vandenbussche
Sabah Kasmi
Lutz Nuhn
D. Brouckaert
Jeroen Van Renterghem
W. Grymonpre
Valérie Vanhoorne
Tom Coenye
Bruno De Geest
et al.
A1
Journal Article
in
INTERNATIONAL JOURNAL OF PHARMACEUTICS
2017
Towards a general model for twin-screw wet granulation : application of a novel validated PBM model to a hydrophilic compound and linking model parameters to blend properties
Daan Van Hauwermeiren
Maxim Verstraeten
Kai Lee
Neil Turnbull
Mary T am Ende
Pankaj Doshi
Thomas De Beer
Ingmar Nopens
C3
Conference
2017
Towards a general model for twin-screw wet granulation : development and calibration of a novel three compartmental PBM model
Daan Van Hauwermeiren
Maxim Verstraeten
Kai Lee
Neil Turnbull
Mary T am Ende
Pankaj Doshi
Thomas De Beer
Ingmar Nopens
C3
Conference
2017
Towards a general model for twin-screw wet granulation : validation of a PBM model through linking calibrated model parameters to process conditions
Daan Van Hauwermeiren
Maxim Verstraeten
Kai Lee
Neil Turnbull
Mary T am Ende
Pankaj Doshi
Thomas De Beer
Ingmar Nopens
C3
Conference
2017
Twin-screw granulation process development: present approaches, understanding and needs
Ashish Kumar
K.V. Gernaey
Ingmar Nopens
Thomas De Beer
Bookchapter
in
Continuous manufacturing of pharmaceuticals
2017
Visualization of compaction behavior of pharmaceutical powders in solid-dosage manufacturing using finite element analysis
Ashish Kumar
Jens Dhondt
Jhony Bertels
Didier Klingeleers
Krist V Gernaey
Ingmar Nopens
Thomas De Beer
C3
Conference
2017
2016
A comparative study between melt granulation/compression and hot melt extrusion/injection molding for the manufacturing of oral sustained release thermoplastic polyurethane matrices
Glenn Verstraete
Pieter Mertens
Wouter Grymonpré
Pieter-Jan Van Bockstal
Thomas De Beer
Matthieu Boone
Luc Van Hoorebeke
Jean Paul Remon
Chris Vervaet
A1
Journal Article
in
INTERNATIONAL JOURNAL OF PHARMACEUTICS
2016
A dynamic design space for primary drying during batch freeze-drying
Séverine Mortier
Pieter-Jan Van Bockstal
Ingmar Nopens
Thomas De Beer
Krist V Gernaey
A1
Journal Article
in
CHIMICA OGGI-CHEMISTRY TODAY
2016
Analysis of inline spatial filter velocimetry for granule size feedback control of a continuous pharmaceutical twin-screw granulator
Niels Nicolaï
Ingmar Nopens
Krist V Gernaey
Thomas De Beer
C3
Conference
2016
Applying supervisory process control practices to continuous pharmaceutical manufacturing
Niels Nicolaï
Ingmar Nopens
Krist V Gernaey
Thomas De Beer
C3
Conference
2016
Assessment and prediction of tablet properties using transmission and backscattering Raman spectroscopy and transmission NIR spectroscopy
Elisabeth Peeters
Ana Tavares da Silva
Maunu Toiviainen
Jeroen Van Renterghem
Jurgen Vercruysse
Mikko Juuti
Joao Almeida Lopes
Thomas De Beer
Chris Vervaet
Jean Paul Remon
A1
Journal Article
in
ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES
2016
Blend uniformity evaluation during continuous mixing in a twin screw granulator by in-line NIR using a moving F-test
Margot Fonteyne
Jurgen Vercruysse
Fien De Leersnyder
Rut Besseling
Ad Gerich
Wim Oostra
Jean Paul Remon
Chris Vervaet
Thomas De Beer
A1
Journal Article
in
ANALYTICA CHIMICA ACTA
2016
Characterization of compaction behaviour of powders in solid-dosage manufacturing using finite element analysis
Ashish Kumar
Jens Dhondt
Johny Bertels
Didier Klingeleers
Krist V Gernaey
Ingmar Nopens
Thomas De Beer
C3
Conference
2016
Comparison of metoprolol tartrate multiple-unit lipid matrix systems produced by different technologies
Aleksandar Aleksovski
Pieter-Jan Van Bockstal
Robert Roškar
Tamás Sovány
Géza Regdon
Thomas De Beer
Chris Vervaet
Rok Dreu
A1
Journal Article
in
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
2016
Continuous manufacturing of delta mannitol by cospray drying with PVP
Valérie Vanhoorne
Pieter-Jan Van Bockstal
Bernd Van Snick
E Peeters
Tinne Monteyne
P Gomes
Thomas De Beer
Jean Paul Remon
Chris Vervaet
A1
Journal Article
in
INTERNATIONAL JOURNAL OF PHARMACEUTICS
2016
Continuous melt granulation: Influence of process and formulation parameters upon granule and tablet properties
Tinne Monteyne
Jochem Vancoillie
Jean Paul Remon
Chris Vervaet
Thomas De Beer
A1
Journal Article
in
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
2016
Continuous twin screw granulation of controlled release formulations with various HPMC grades
Valérie Vanhoorne
L Janssens
J Vercruysse
Thomas De Beer
Jean Paul Remon
Chris Vervaet
A1
Journal Article
in
INTERNATIONAL JOURNAL OF PHARMACEUTICS
2016
Development and validation of an at-line fast and non-destructive Raman spectroscopic method for the quantification of multiple components in liquid detergent compositions
Davinia Brouckaert
J Uyttersprot
W Broeckx
Thomas De Beer
A1
Journal Article
in
ANALYTICA CHIMICA ACTA
2016
Development of a controlled release formulation by continuous twin screw granulation : influence of process and formulation parameters
Valérie Vanhoorne
Brecht Vanbillemont
J Vercruysse
Fien De Leersnyder
P Gomes
Thomas De Beer
Jean Paul Remon
Chris Vervaet
A1
Journal Article
in
INTERNATIONAL JOURNAL OF PHARMACEUTICS
2016
Development of a process map : a step towards a regime map for steady-state high shear wet twin screw granulation
Ashish Kumar
Jens Dhondt
Jurgen Vercruysse
Fien De Leersnyder
Valérie Vanhoorne
Chris Vervaet
Jean Paul Remon
Krist V. Gernaey
Thomas De Beer
Ingmar Nopens
A1
Journal Article
in
POWDER TECHNOLOGY
2016
Development of formulation and process knowledge for continuous twin-screw melt granulation
Tinne Monteyne
Thomas De Beer
Chris Vervaet
Dissertation
2016
Dressings loaded with cyclodextrin-hamamelitannin complexes increase Staphylococcus aureus susceptibility toward antibiotics both in single as well as in mixed biofilm communities
Gilles Brackman
Maria José Garcia-Fernandez
Joke Lenoir
Laurens De Meyer
Jean Paul Remon
Thomas De Beer
Angel Concheiro
Carmen Alvarez-Lorenzo
Tom Coenye
A1
Journal Article
in
MACROMOLECULAR BIOSCIENCE
2016
Evaluation of fast spectroscopic analysis techniques for freeze-dried live, attenuated virus vaccines
Laurent Hansen
Thomas De Beer
Rim Daoussi
Dissertation
2016
Hydrophilic thermoplastic polyurethanes for the manufacturing of highly dosed oral sustained release matrices via hot melt extrusion and injection molding
Glenn Verstraete
Jeroen Van Renterghem
Pieter-Jan Van Bockstal
Sabah Kasmi
Bruno De Geest
Thomas De Beer
Jean Paul Remon
Chris Vervaet
A1
Journal Article
in
INTERNATIONAL JOURNAL OF PHARMACEUTICS
2016
Impact of vacuum-induced surface freezing on inter- and intra-vial heterogeneity
Irene Oddone
Pieter-Jan Van Bockstal
Thomas De Beer
Roberto Pisano
A1
Journal Article
in
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
2016
Improved tabletability after a polymorphic transition of delta-mannitol during twin screw granulation
Valérie Vanhoorne
Bram Bekaert
E Peeters
Thomas De Beer
Jean Paul Remon
Chris Vervaet
A1
Journal Article
in
INTERNATIONAL JOURNAL OF PHARMACEUTICS
2016
Linking granulation performance with residence time and granulation liquid distributions in twin-screw granulation : an experimental investigation
Ashish Kumar
Maija Alakarjula
Valérie Vanhoorne
Maunu Toiviainen
Fien De Leersnyder
Jurgen Vercruysse
Mikko Juuti
Jarkko Ketolainen
Chris Vervaet
Jean Paul Remon
et al.
A1
Journal Article
in
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
2016
Methodology and pitfalls when calibrating a PBM : the case of twin-screw wet granulation
Daan Van Hauwermeiren
Thomas De Beer
Michael Ghijs
Maxim Verstraeten
Ashish Kumar
Krist V Gernaey
Kai Lee
Mary T am Ende
Pankaj Doshi
Ingmar Nopens
C3
Conference
2016
Model-based analysis of a twin-screw wet granulation system for continuous solid dosage manufacturing
Ashish Kumar
Jurgen Vercruysse
Séverine Mortier
Chris Vervaet
Jean Paul Remon
Krist V Gernaey
Thomas De Beer
Ingmar Nopens
A1
Journal Article
in
COMPUTERS & CHEMICAL ENGINEERING
2016
Model-based process analysis in continuous manufacturing of pharmaceuticals : calibration of a fluid bed dryer model
Michael Ghijs
Fien De Leersnyder
Daan Van Hauwermeiren
Valérie Vanhoorne
Jurgen Vercruysse
Philippe Cappuyns
Séverine Mortier
Thomas De Beer
Krist Gernaey
Ingmar Nopens
C3
Conference
2016
Modelling and sensitivity analysis of urinary platinum excretion in anticancer chemotherapy for the recovery of platinum
Karel Folens
Séverine Mortier
Janis Baeten
KAREN COUVREUR
Robin Michelet
Krist V Gernaey
Thomas De Beer
Gijs Du Laing
Ingmar Nopens
A1
Journal Article
in
SUSTAINABLE CHEMISTRY AND PHARMACY
2016
Spectroscopic evaluation of a freeze-dried vaccine during an accelerated stability study
Laurent Hansen
Jeroen Van Renterghem
Rim Daoussi
Chris Vervaet
Jean Paul Remon
Thomas De Beer
A1
Journal Article
in
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
2016
Spontaneous protein adsorption on graphene oxide nanosheets allowing efficient intracellular vaccine protein delivery
Hui Li
Kaat Fierens
Zhiyue Zhang
Nane Vanparijs
Martijn Schuijs
Katleen Van Steendam
Natalia Feiner Gracia
Riet De Rycke
Thomas De Beer
Ans De Beuckelaer
et al.
A1
Journal Article
in
ACS APPLIED MATERIALS & INTERFACES
2016
Stearic acid and high molecular weight PEO as matrix for the highly water soluble metoprolol tartrate in continuous twin-screw melt granulation
Tinne Monteyne
Peter Adriaensens
Davinia Brouckaert
Jean Paul Remon
Chris Vervaet
Thomas De Beer
A1
Journal Article
in
INTERNATIONAL JOURNAL OF PHARMACEUTICS
2016
The use of rheology combined with differential scanning calorimetry to elucidate the granulation mechanism of an immiscible formulation during continuous twin-screw melt granulation
Tinne Monteyne
Liza Heeze
Séverine Mortier
Klaus Oldörp
Ruth Cardinaels
Ingmar Nopens
Chris Vervaet
Jean Paul Remon
Thomas De Beer
A1
Journal Article
in
PHARMACEUTICAL RESEARCH
2016
The use of rheology to elucidate the granulation mechanisms of a miscible and immiscible system during continuous twin-screw melt granulation
Tinne Monteyne
Liza Heeze
Séverine Mortier
Klaus Oldörp
Ingmar Nopens
Jean Paul Remon
Chris Vervaet
Thomas De Beer
A1
Journal Article
in
INTERNATIONAL JOURNAL OF PHARMACEUTICS
2016
Uncertainty analysis as essential step in the establishment of the dynamic Design Space of primary drying during freeze-drying
Séverine Mortier
Pieter-Jan Van Bockstal
Jos Corver
Ingmar Nopens
Krist V Gernaey
Thomas De Beer
A1
Journal Article
in
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
2016
2015
Analysis of a twin-screw granulation process using a combined experimental and computational approach
Ashish Kumar
Jurgen Vercruysse
Krist V Gernaey
Thomas De Beer
Ingmar Nopens
C3
Conference
2015
Combined experimental and computational approach to elucidate the twin-screw granulation process
Ashish Kumar
Jurgen Vercruysse
Chris Vervaet
Jean Paul Remon
Krist V Gernaey
Thomas De Beer
Ingmar Nopens
C3
Conference
2015
Conceptual framework for model-based analysis of residence time distribution in twin-screw granulation
Ashish Kumar
Jurgen Vercruysse
Valérie Vanhoorne
Maunu Toiviainen
Pierre-Emmanuel Panouillot
Mikko Juuti
Chris Vervaet
Jean Paul Remon
Krist V Gernaey
Thomas De Beer
et al.
A1
Journal Article
in
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
2015
Detailed simulation of particle and liquid distribution in the mixing zone of a TwinScrew granulator
Ashish Kumar
Stefan Radl
Johannes G Khinast
Krist V Gernaey
Thomas De Beer
Ingmar Nopens
C3
Conference
2015
Development of regime map for steady-state high shear wet twin-screw granulation
Ashish Kumar
Jens Dhondt
Jurgen Vercruysse
Fien De Leersnyder
Valérie Vanhoorne
Krist V Gernaey
Thomas De Beer
Ingmar Nopens
C3
Conference
2015
Enteric protection of naproxen in a fixed-dose combination product produced by hot-melt co-extrusion
An-Katrien Vynckier
M De Beer
Tinne Monteyne
Jody Voorspoels
Thomas De Beer
Jean Paul Remon
Chris Vervaet
A1
Journal Article
in
INTERNATIONAL JOURNAL OF PHARMACEUTICS
2015
Evaluation of an in-line particle imaging tool for monitoring twin-screw granulation performance
Ashish Kumar
Jens Dhondt
Fien De Leersnyder
Jurgen Vercruysse
Valérie Vanhoorne
Chris Vervaet
Jean Paul Remon
Krist V Gernaey
Thomas De Beer
Ingmar Nopens
A1
Journal Article
in
POWDER TECHNOLOGY
2015
Evaluation of spin freezing versus conventional freezing as part of a continuous pharmaceutical freeze-drying concept for unit doses
Laurens De Meyer
Pieter-Jan Van Bockstal
Jos Corver
Chris Vervaet
Jean Paul Remon
Thomas De Beer
A1
Journal Article
in
INTERNATIONAL JOURNAL OF PHARMACEUTICS
2015
Experimental and model-based analysis of twin-screw wet granulation in pharmaceutical processes
Ashish Kumar
Ingmar Nopens
Thomas De Beer
Krist V Gernaey
Dissertation
2015
Experimental investigation linking granulation performance with Residence time and granulation liquid distributions in TwinScrew granulation
Ashish Kumar
Maija Alkarjula
Valérie Vanhoorne
Maunu Toiviainen
Mikko Juuti
Chris Vervaet
Jarkko Ketolainen
Krist V Gernaey
Ingmar Nopens
Thomas De Beer
C3
Conference
2015
Experimental investigation of residence time, granulation liquid and granule size distributions in twin-screw granulation
Ashish Kumar
Maija Alakarjula
Valérie Vanhoorne
Maunu Toiviainen
Mikko Juuti
Chris Vervaet
Jarkko Ketolainen
Krist V Gernaey
Thomas De Beer
Ingmar Nopens
C3
Conference
2015
Experimental investigation of the link between granulation performance, residence time and granulation liquid distribution in twin-screw granulation
Ashish Kumar
Maija Alakarjula
Valérie Vanhoorne
Maunu Toiviainen
Mikko Juuti
Chris Vervaet
Jarkko Ketolainen
Krist V Gernaey
Thomas De Beer
Ingmar Nopens
C3
Conference
2015
Fatty acids for controlled release applications: a comparison between prilling and solid lipid extrusion as manufacturing techniques
Anouk Vervaeck
Tinne Monteyne
Florence Siepmann
Matthieu Boone
Luc Van Hoorebeke
Thomas De Beer
Jürgen Siepmann
Jean Paul Remon
Chris Vervaet
A1
Journal Article
in
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
2015
Freeze-drying of live virus vaccines : a review
Laurent Hansen
R Daoussi
Chris Vervaet
Jean Paul Remon
Thomas De Beer
A1
Journal Article
in
VACCINE
2015
FTIR spectroscopy for the detection and evaluation of live attenuated viruses in freeze dried vaccine formulations
Laurent Hansen
Thomas De Beer
Karin Pierre
Soumya Pastoret
Astrid Bonnegarde-Bernard
Rim Daoussi
Chris Vervaet
Jean Paul Remon
A1
Journal Article
in
BIOTECHNOLOGY PROGRESS
2015
Gaining process knowledge by using mechanistic models for fluidized bed drying in a continuous manufacturing environment
Séverine Mortier
Ingmar Nopens
Krist V Gernaey
Thomas De Beer
C3
Conference
2015
Hot-melt extrusion of polyvinyl alcohol for oral immediate release applications
Wesley De Jaeghere
Thomas De Beer
Jan Van Bocxlaer
Jean Paul Remon
Chris Vervaet
A1
Journal Article
in
INTERNATIONAL JOURNAL OF PHARMACEUTICS
2015
Impact of screw configuration on the particle size distribution of granules produced by twin screw granulation
Jurgen Vercruysse
Anneleen Burggraeve
Margot Fonteyne
P Cappuyns
U Delaet
I Van Assche
Thomas De Beer
Jean Paul Remon
Chris Vervaet
A1
Journal Article
in
INTERNATIONAL JOURNAL OF PHARMACEUTICS
2015
In-line near infrared spectroscopy during freeze-drying as a tool to measure efficiency of hydrogen bond formation between protein and sugar, predictive of protein storage stability
Maarten A. Mensink
Pieter-Jan Van Bockstal
Sigrid Pieters
Laurens De Meyer
Henderik W Frijlink
Kees van der Voort Maarschalk
Wouter LJ Hinrichs
Thomas De Beer
A1
Journal Article
in
INTERNATIONAL JOURNAL OF PHARMACEUTICS
2015
Investigation of twin screw granulation : integrating experimental and computational approaches
Ashish Kumar
Krist V Gernaey
Thomas De Beer
Ingmar Nopens
C3
Conference
2015
Model-based characterisation of twin-screw granulation system for continuous solid dosage manufacturing
Ashish Kumar
Krist V Gernaey
Thomas De Beer
Ingmar Nopens
P1
Conference
2015
Model-based optimization of the primary drying step during freeze-drying
Séverine Mortier
Pieter-Jan Van Bockstal
Ingmar Nopens
Krist V Gernaey
Thomas De Beer
P1
Conference
2015
Model-based optimization of the primary drying step during freeze-drying
Séverine Mortier
Krist V Gernaey
Ingmar Nopens
Pieter-Jan Van Bockstal
Thomas De Beer
C3
Conference
2015
Process analytical technology for continuous manufacturing of solid-dosage forms
Margot Fonteyne
Jurgen Vercruysse
Fien De Leersnyder
Bernd Van Snick
Chris Vervaet
Jean Paul Remon
Thomas De Beer
A1
Journal Article
in
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
2015
Reduction of tablet weight variability by optimizing paddle speed in the forced feeder of a high-speed rotary tablet press
Elisabeth Peeters
Thomas De Beer
Chris Vervaet
Jean Paul Remon
A1
Journal Article
in
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
2015
Thermoplastic polyurethanes for the manufacturing of highly dosed oral sustained release matrices via hot melt extrusion and injection molding
Bart Claeys
Anouk Vervaeck
Xander Hillewaere
Sam Possemiers
Laurent Hansen
Thomas De Beer
Jean Paul Remon
Chris Vervaet
A1
Journal Article
in
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
2015
Towards model-based control of granule moisture content during continuous wet granulation
Niels Nicolaï
Krist V Gernaey
Ingmar Nopens
Thomas De Beer
C3
Conference
2015
Use of a continuous twin screw granulation and drying system during formulation development and process optimization
Jurgen Vercruysse
Elisabeth Peeters
Margot Fonteyne
P Cappuyns
U Delaet
I Van Assche
Thomas De Beer
Jean Paul Remon
Chris Vervaet
A1
Journal Article
in
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
2015
2014
A two-dimensional PBM for continuous drying of a population of granules including drying and breakage
Séverine Mortier
Krist V Gernaey
Thomas De Beer
Ingmar Nopens
C3
Conference
2014
Analysing drying unit performance in a continuous pharmaceutical manufacturing line by means of mass-energy balances
Séverine Mortier
Krist V Gernaey
Thomas De Beer
Ingmar Nopens
A1
Journal Article
in
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
2014
Applying reconstruction methods on the solution of a moment-based pharmaceutical drying process Population Balance Model
Séverine Mortier
Krist V Gernaey
Thomas De Beer
Ingmar Nopens
C3
Conference
2014
Co-extruded solid solutions as immediate release fixed-dose combinations
Lien Dierickx
Bernd Van Snick
Tinne Monteyne
Thomas De Beer
Jean Paul Remon
Chris Vervaet
A1
Journal Article
in
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
2014
Comparison of techniques for reconstruction of a distribution from moments in the context of a pharmaceutical drying process
Séverine Mortier
Thomas De Beer
Krist V Gernaey
Ingmar Nopens
A1
Journal Article
in
COMPUTERS & CHEMICAL ENGINEERING
2014
Development and validation of process analytical methods for a continuous pharmaceutical manufacturing process of tablets based on wet granulation
Margot Fonteyne
Thomas De Beer
Jean Paul Remon
Dissertation
2014
Development of a population balance model for continuous twin-screw granulation in pharmaceutical manufacturing
Ashish Kumar
Krist V Gernaey
Thomas De Beer
Ingmar Nopens
C3
Conference
2014
Development of critical quality attributes control strategies in a continuous high shear wet granulation process
Niels Nicolaï
Thomas De Beer
Krist V Gernaey
Ingmar Nopens
C3
Conference
2014
Distribution of binder in granules produced by means of twin screw granulation
Margot Fonteyne
Andrew Luke Fussell
Jurgen Vercruysse
Chris Vervaet
Jean Paul Remon
Clare Strachan
Thomas Rades
Thomas De Beer
A1
Journal Article
in
INTERNATIONAL JOURNAL OF PHARMACEUTICS
2014
Experimental and model-based investigation of twin screw granulation: towards more profound process knowledge
Ashish Kumar
Krist V Gernaey
Thomas De Beer
Ingmar Nopens
C3
Conference
2014
Experimental investigation of granule shape and size dynamics in twin-screw granulation
Ashish Kumar
Jurgen Vercruysse
Krist V Gernaey
Thomas De Beer
Ingmar Nopens
C3
Conference
2014
Experimental investigation of granule size and shape dynamics in twin-screw granulation
Ashish Kumar
Jurgen Vercruysse
Giacomo Bellandi
Krist V Gernaey
Chris Vervaet
Jean Paul Remon
Thomas De Beer
Ingmar Nopens
A1
Journal Article
in
INTERNATIONAL JOURNAL OF PHARMACEUTICS
2014
Experimental investigation of residence time distribution in twin-screw granulation
Ashish Kumar
Jurgen Vercruysse
Maunu Toiviainen
Pierre-Emmanuel Panouillot
Mikko Juuti
Valérie Vanhoorne
Krist V Gernaey
Thomas De Beer
Ingmar Nopens
C3
Conference
2014
Formulation of itraconazole nanococrystals and evaluation of their bioavailability in dogs
Lieselotte De Smet
Lien Saerens
Thomas De Beer
Robert Carleer
Peter Adriaensens
Jan Van Bocxlaer
Chris Vervaet
Jean Paul Remon
A1
Journal Article
in
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
2014
Global sensitivity analysis applied to drying models for one or a population of granules
Séverine Mortier
Krist V Gernaey
Thomas De Beer
Ingmar Nopens
A1
Journal Article
in
AICHE JOURNAL
2014
Hot-melt co-extrusion for the production of fixed-dose combination products with a controlled release ethylcellulose matrix core
An-Katrien Vynckier
Lien Dierickx
Lien Saerens
Jody Voorspoels
Yves Gonnissen
Thomas De Beer
Chris Vervaet
Jean Paul Remon
A1
Journal Article
in
INTERNATIONAL JOURNAL OF PHARMACEUTICS
2014
In-line solid state prediction during pharmaceutical hot-melt extrusion in a 12 mm twin screw extruder using Raman spectroscopy
Lien Saerens
Dima Ghanam
Cedric Raemdonck
Kjell Francois
Jürgen Manz
Rainer Krüger
Susan Krüger
Chris Vervaet
Jean Paul Remon
Thomas De Beer
A1
Journal Article
in
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
2014
Influence of raw material properties upon critical quality attributes of continuously produced granules and tablets
Margot Fonteyne
Henrika Wickström
Elisabeth Peeters
Jurgen Vercruysse
Henrik Ehlers
Björn-Hendrik Peters
Jean Paul Remon
Chris Vervaet
Jarkko Ketolainen
Niklas Sandler
et al.
A1
Journal Article
in
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
2014
Mechanistic modelling for process understanding of fluidized bed drying process part of a full continuous pharmaceutical manufacturing line
Séverine Mortier
Thomas De Beer
Krist V Gernaey
Ingmar Nopens
C3
Conference
2014
Mixing and transport during pharmaceutical twin-screw wet granulation : experimental analysis via chemical imaging
Ashish Kumar
Jurgen Vercruysse
Maunu Toiviainen
Pierre-Emmanuel Panouillot
Mikko Juuti
Valérie Vanhoorne
Chris Vervaet
Jean Paul Remon
Krist V Gernaey
Thomas De Beer
et al.
A1
Journal Article
in
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
2014
Model-based analysis and experimental validation of residence time distribution in twin-screw granulation
Ashish Kumar
Jurgen Vercruysse
Maunu Toiviainen
Pierre-Emmanuel Panouillot
Mikko Juuti
Valérie Vanhoorne
Krist V Gernaey
Thomas De Beer
Ingmar Nopens
C3
Conference
2014
Modelling the drying behaviour of wet granules in the context of fully continuous pharmaceutical tablet manufacturing
Séverine Mortier
Ingmar Nopens
Thomas De Beer
Krist V Genaey
Dissertation
2014
Moisture and drug solid-state monitoring during a continuous drying process using empirical and mass balance models
Margot Fonteyne
Delphine Gildemyn
Elisabeth Peeters
Séverine Mortier
Jurgen Vercruysse
Krist V Gernaey
Chris Vervaet
Jean Paul Remon
Ingmar Nopens
Thomas De Beer
A1
Journal Article
in
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
2014
Monitoring and modelling of a continuous from-powder-to-tablet process line
Séverine Mortier
Ingmar Nopens
Thomas De Beer
Krist V Gernaey
A1
Journal Article
in
CHIMICA OGGI-CHEMISTRY TODAY
2014
NIR spectroscopic method for the in-line moisture assessment during drying in a six-segmented fluid bed dryer of a continuous tablet production line : validation of quantifying abilities and uncertainty assessment
Margot Fonteyne
Julen Arruabarrena
Jacques de Beer
Mario Hellings
Tom Van Den Kerkhof
Anneleen Burggraeve
Chris Vervaet
Jean Paul Remon
Thomas De Beer
A1
Journal Article
in
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
2014
Prilling as manufacturing technique for multiparticulate lipid/PEG fixed-dose combinations
Anouk Vervaeck
Tinne Monteyne
Lien Saerens
Thomas De Beer
Jean Paul Remon
Chris Vervaet
A1
Journal Article
in
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
2014
Process monitoring and modeling of a continuous pharmaceutical from powder to tablet process line using a mass and energy balance
Séverine Mortier
Thomas De Beer
Ingmar Nopens
Krist V Gernaey
C3
Conference
2014
Process monitoring and visualization solutions for hot-melt extrusion : a review
Lien Saerens
Chris Vervaet
Jean Paul Remon
Thomas De Beer
A1
Journal Article
in
JOURNAL OF PHARMACY AND PHARMACOLOGY
2014
Raman model development for the protein conformational state classification in different freeze-dried formulations
Sigrid Pieters
Jean-Michel Roger
Thomas De Beer
Matthias D'Hondt
Bart De Spiegeleer
Yvan Vander Heyden
A1
Journal Article
in
ANALYTICA CHIMICA ACTA
2014
Release characteristics of polyurethane tablets containing dicarboxylic acids as release modifiers: a case study with diprophylline
Bart Claeys
Sander De Bruyn
Laurent Hansen
Thomas De Beer
Jean Paul Remon
Chris Vervaet
A1
Journal Article
in
INTERNATIONAL JOURNAL OF PHARMACEUTICS
2014
Two-dimensional PBM for simultaneous modelling of drying and breakage of pharmaceutical granules
Séverine Mortier
Ingmar Nopens
Krist V Gernaey
Thomas De Beer
C3
Conference
2014
Validation of an in-line Raman spectroscopic method for continuous active pharmaceutical ingredient quantification during pharmaceutical hot-melt extrusion
Lien Saerens
N Segher
Chris Vervaet
Jean Paul Remon
Thomas De Beer
A1
Journal Article
in
ANALYTICA CHIMICA ACTA
2014
Visualization and understanding of the granulation liquid mixing and distribution during continuous twin screw granulation using NIR chemical imaging
Jurgen Vercruysse
Maunu Toiviainen
Margot Fonteyne
Niko Helkimo
Jarkko Ketolainen
Mikko Juuti
Urbain Delaet
Ivo Van Assche
Jean Paul Remon
Chris Vervaet
et al.
A1
Journal Article
in
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
2014
2013
A GLUE uncertainty analysis of a drying model of pharmaceutical granules
Séverine Mortier
Stijn Van Hoey
Katrijn Cierkens
Krist V Gernaey
Piet Seuntjens
Bernard De Baets
Thomas De Beer
Ingmar Nopens
A1
Journal Article
in
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
2013
An experimental study on effect of screw configuration in twin screw wet granulation
Ashish Kumar
Jurgen Vercruysse
Krist V Gernaey
Ingmar Nopens
Thomas De Beer
C3
Conference
2013
Development of a population balance model of a pharmaceutical drying process and testing of solution methods
Séverine Mortier
Krist Gernaey
Thomas De Beer
Ingmar Nopens
A1
Journal Article
in
COMPUTERS & CHEMICAL ENGINEERING
2013
Evaluation of particle shape and size evolution during high-shear wet granulatoin using twin-screw granulator
Ashish Kumar
Jurgen Vercruysse
Krist V Gernaey
Thomas De Beer
Ingmar Nopens
C3
Conference
2013
Global sensitivity analysis on a PBM-model describing the drying behaviour of wet pharmaceutical granules
Séverine Mortier
Krist V Gernaey
Thomas De Beer
Ingmar Nopens
C1
Conference
2013
Model-based analysis of high shear wet granulation from batch to continuous processes in pharmaceutical production: a critical review
Ashish Kumar
Krist V Gernaey
Thomas De Beer
Ingmar Nopens
A1
Journal Article
in
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
2013
Near-infrared spectroscopic evaluation of lyophilized viral vaccine formulations
Laurent Hansen
Thomas De Beer
Sigrid Pieters
Yvan Vander Heyden
Chris Vervaet
Jean Paul Remon
Jean-Pierrre Montenez
Rim Daoussi
A1
Journal Article
in
BIOTECHNOLOGY PROGRESS
2013
One dimensional model of the prediction of residence time distribution granulation in a twin-screw granulator
Ashish Kumar
Krist V Gernaey
Thomas De Beer
Ingmar Nopens
C3
Conference
2013
Particle sizing measurements in pharmaceutical applications : comparison of in-process methods versus off-line methods
Ana Tavares da Silva
Anneleen Burggraeve
Quenten Denon
Paul Van der Meeren
Niklas Sandler
Tom Van Den Kerkhof
Mario Hellings
Chris Vervaet
Jean Paul Remon
João Almeida Lopes
et al.
A1
Journal Article
in
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
2013
Prilling of fatty acids as a continuous process for the development of controlled release multiparticulate dosage forms
Anouk Vervaeck
Lien Saerens
Bruno De Geest
Thomas De Beer
R Carleer
P Adriaensens
Jean Paul Remon
Chris Vervaet
A1
Journal Article
in
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
2013
Process analytical tools for monitoring, understanding, and control of pharmaceutical fluidized bed granulation: a review
Anneleen Burggraeve
Tinne Monteyne
Chris Vervaet
Jean Paul Remon
Thomas De Beer
A1
Journal Article
in
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
2013
Process monitoring for the continuous tabletting line ConsiGma using in-line measurements
Séverine Mortier
KV Gernaey
Thomas De Beer
Ingmar Nopens
C3
Conference
2013
Process monitoring of a full continuous pharmaceutical tabletting line : mass and energy balance analysis
Séverine Mortier
Ingmar Nopens
Thomas De Beer
Krist V Gernaey
C3
Conference
2013
Raman spectroscopy and multivariate analysis for the rapid discrimination between native-like and non-native states in freeze-dried protein formulations
Sigrid Pieters
Yvan Vander Heyden
Jean-Michel Roger
Matthias D'Hondt
Laurent Hansen
Bernard Palagos
Bart De Spiegeleer
Jean Paul Remon
Chris Vervaet
Thomas De Beer
A1
Journal Article
in
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
2013
Real-time assessment of critical quality attributes of a continuous granulation process
Margot Fonteyne
Jurgen Vercruysse
Damián Córdoba Díaz
Delphine Gildemyn
Chris Vervaet
Jean Paul Remon
Thomas De Beer
A1
Journal Article
in
PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY
2013
Reduction of a single granule drying model: an essential step in preparation of a population balance model with a continuous growth term
Séverine Mortier
Timothy Van Daele
Krist V Gernaey
Thomas De Beer
Ingmar Nopens
A1
Journal Article
in
AICHE JOURNAL
2013
Robust calibrations on reduced sample sets for API content prediction in tablets: definition of a cost-effective NIR model development strategy
Sigrid Pieters
Wouter Saeys
Tom Van den Kerkhof
Mohammad Goodarzi
Mario Hellings
Thomas De Beer
Yvan Vander Heyden
A1
Journal Article
in
ANALYTICA CHIMICA ACTA
2013
Scenario analysis on a PBM describing the drying behaviour of wet pharmaceutical granules
Séverine Mortier
Krist V Gernaey
Thomas De Beer
Ingmar Nopens
C1
Conference
2013
Spectroscopic process monitoring for quality assessment, visualization and understanding of pharmaceutical hot-melt extrusion
Lien Saerens
Thomas De Beer
Chris Vervaet
Dissertation
2013
Stability and repeatability of a continuous twin screw granulation and drying system
Jurgen Vercruysse
U Delaet
I Van Assche
P Cappuyns
F Arata
G Caporicci
Thomas De Beer
Jean Paul Remon
Chris Vervaet
A1
Journal Article
in
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
2013
The use of mass and energy balances for process monitoring of a full continuous pharmaceutical from powder to tablet manufacturing
Séverine Mortier
Ingmar Nopens
Thomas De Beer
Krist V Gernaey
C3
Conference
2013
Using a PBM to describe the drying behaviour of wet pharmaceutical granules : scenario analysis and GSA
Séverine Mortier
Ingmar Nopens
Thomas De Beer
Krist V Gernaey
C3
Conference
2013
Visualization and process understanding of material behavior in the extrusion barrel during a hot-melt extrusion process using Raman spectroscopy
Lien Saerens
Chris Vervaet
Jean Paul Remon
Thomas De Beer
A1
Journal Article
in
ANALYTICAL CHEMISTRY
2013
2012
Application of global sensitivity analysis as preparatory step for reduction of a drying model of pharmaceutical granules
Séverine Mortier
Ingmar Nopens
Thomas De Beer
Krist Gernaey
C3
Conference
2012
Application of model uncertainty analysis on the modelling of the drying behaviour of single pharmaceutical granules
Séverine Mortier
Stijn Van Hoey
Katrijn Cierkens
Thomas De Beer
Kris Gernaey
Ingmar Nopens
C3
Conference
2012
Application of model uncertainty analysis on the modelling of the drying behaviour of single pharmaceutical granules
Séverine Mortier
Stijn Van Hoey
Katrijn Cierkens
Thomas De Beer
Kris V Gernaey
Ingmar Nopens
C3
Conference
2012
Can the use of coccidiostats in poultry breeding lead to residues in vegetables?: an experimental study
Nathan Broekaert
Els Daeseleire
Evelyne Delezie
Bart Vandecasteele
Thomas De Beer
Christof Van Poucke
A1
Journal Article
in
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
2012
Co-extrusion as manufacturing technique for fixed-dose combination mini-matrices
Lien Dierickx
Lien Saerens
Ana Almeida
Thomas De Beer
Jean Paul Remon
Chris Vervaet
A1
Journal Article
in
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
2012
Continuous twin screw granulation: influence of process variables on granule and tablet quality
Jurgen Vercruysse
D Córdoba Díaz
Elisabeth Peeters
Margot Fonteyne
U Delaet
I Van Assche
Thomas De Beer
Jean Paul Remon
Chris Vervaet
A1
Journal Article
in
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
2012
Development of a fluid bed granulation process control strategy based on real-time process and product measurements
Anneleen Burggraeve
Ana Tavares da Silva
Tom Van den Kerkhof
Mario Hellings
Chris Vervaet
Jean Paul Remon
Yvan Vander Heyden
Thomas De Beer
A1
Journal Article
in
TALANTA
2012
Development of process analytical and control methodologies for pharmaceutical wet granulation processes
Anneleen Burggraeve
Thomas De Beer
Chris Vervaet
Dissertation
2012
Effect of disintegrants on the properties of multiparticulate tablets comprising starch pellets and excipient granules
Samata Mehta
Thomas De Beer
Jean Paul Remon
Chris Vervaet
A1
Journal Article
in
INTERNATIONAL JOURNAL OF PHARMACEUTICS
2012
In-line NIR spectroscopy for the understanding of polymer-drug interaction during pharmaceutical hot-melt extrusion
Lien Saerens
Lien Dierickx
Thomas Quintens
Peter Adriaensens
Robert Carleer
Chris Vervaet
Jean Paul Remon
Thomas De Beer
A1
Journal Article
in
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
2012
Mechanistic modelling of the drying behaviour of single pharmaceutical granules
Séverine Mortier
Thomas De Beer
Krist Gernaey
Jurgen Vercruysse
Margot Fonteyne
Jean Paul Remon
Chris Vervaet
Ingmar Nopens
A1
Journal Article
in
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
2012
Near-infrared spectroscopy for in-line monitoring of protein unfolding and its interactions with lyoprotectants during freeze-drying
Sigrid Pieters
Thomas De Beer
Julia Kasper
Dorien Boulpaep
Oliwia Waszkiewicz
Mohammad Goodarzi
Christophe Tistaert
Wolfgang Friess
Jean Paul Remon
Chris Vervaet
et al.
A1
Journal Article
in
ANALYTICAL CHEMISTRY
2012
Phenolic compounds and anti-oxidant capacity of twelve morphologically heterogeneous bamboo species
Laura Van Hoyweghen
Thomas De Beer
Dieter Deforce
Arne Heyerick
A1
Journal Article
in
PHYTOCHEMICAL ANALYSIS
2012
Prediction of quality attributes of continuously produced granules using complementary pat tools
Margot Fonteyne
Sandra Liliana De Oliveira Soares
Jurgen Vercruysse
Elisabeth Peeters
Anneleen Burggraeve
Chris Vervaet
Jean Paul Remon
Niklas Sandler
Thomas De Beer
A1
Journal Article
in
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
2012
Preparation and evaluation of sustained-release matrix tablets based on metoprolol and an acrylic carrier using injection moulding
Thomas Quinten
GP Andrews
Thomas De Beer
Lien Saerens
Wim Bouquet-Geerardyn
DS Jones
P Hornsby
Jean Paul Remon
Chris Vervaet
A1
Journal Article
in
AAPS PHARMSCITECH
2012
Suitability of differently formulated dry powder Newcastle disease vaccines for mass vaccination of poultry
Katrien Huyge
Kristien Van Reeth
Thomas De Beer
Wil JM Landman
Jo HH van Eck
Jean Paul Remon
Chris Vervaet
A1
Journal Article
in
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
2012
Sustained release from hot-melt extruded matrices based on ethylene vinyl acetate and polyethylene oxide
Ana Almeida
Loes Brabant
Florence Siepmann
Thomas De Beer
Wim Bouquet-Geerardyn
Luc Van Hoorebeke
Jurgen Siepmann
Jean Paul Remon
Chris Vervaet
A1
Journal Article
in
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
2012
Uncertainty analysis applied on drying model for pharmaceutical granules
Séverine Mortier
Stijn Van Hoey
Katrijn Cierkens
Thomas De Beer
Krist V Gernaey
Ingmar Nopens
C3
Conference
2012
Upscaling and in-line process monitoring via spectroscopic techniques of ethylene vinyl acetate hot-melt extruded formulations
Ana Almeida
Lien Saerens
Thomas De Beer
Jean Paul Remon
Chris Vervaet
A1
Journal Article
in
INTERNATIONAL JOURNAL OF PHARMACEUTICS
2012
2011
Batch statistical process control of a fluid bed granulation process using in-line spatial filter velocimetry and product temperature measurements
Anneleen Burggraeve
T Van den Kerkhof
M Hellings
Jean Paul Remon
Chris Vervaet
Thomas De Beer
A1
Journal Article
in
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
2011
Detection of counterfeit Viagra® by Raman microspectroscopy imaging and multivariate analysis
Pierre-Yves Sacré
Eric Deconinck
Lien Saerens
Thomas De Beer
Patricia Courselle
Roy Vancauwenberghe
Patrice Chiap
Jacques Crommen
Jacques O De Beer
A1
Journal Article
in
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
2011
Development and evaluation of injection-moulded sustained-release tablets containing ethylcellulose and polyethylene oxide
Thomas Quinten
Thomas De Beer
Ana Almeida
Jelle Vlassenbroeck
Luc Van Hoorebeke
Jean Paul Remon
A1
Journal Article
in
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
2011
Ethylene vinyl acetate as matrix for oral sustained release dosage forms produced via hot-melt extrusion
Ana Almeida
Sam Possemiers
Matthieu Boone
Thomas De Beer
Thomas Quinten
Luc Van Hoorebeke
Jean Paul Remon
Chris Vervaet
A1
Journal Article
in
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
2011
Lyophilization of protein-loaded polyelectrolyte microcapsules
Marie-Luce De Temmerman
Joanna Rejman
Johan Grooten
Thomas De Beer
Chris Vervaet
Jo Demeester
Stefaan De Smedt
A1
Journal Article
in
PHARMACEUTICAL RESEARCH
2011
Mechanistic modelling of fluidized bed drying processes of wet porous granules: a review
Séverine Mortier
Thomas De Beer
Krist V Gernaey
Jean Paul Remon
Chris Vervaet
Ingmar Nopens
A1
Journal Article
in
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
2011
Modelling of drying processes of pharmaceutical granules
Séverine Mortier
Sreepriya Vedantam
Thomas De Beer
KV Gernaey
Jean Paul Remon
Chris Vervaet
Ingmar Nopens
C3
Conference
2011
Modelling of drying processes of pharmaceutical granules
Séverine Mortier
Sreepriya Vedantam
Thomas De Beer
KV Gernaey
Margot Fonteyne
Jurgen Vercruysse
Jean Paul Remon
Chris Vervaet
Ingmar Nopens
C3
Conference
2011
Near infrared and Raman spectroscopy for the in-process monitoring of pharmaceutical production processes
Thomas De Beer
Anneleen Burggraeve
Margot Fonteyne
Lien Saerens
Jean Paul Remon
Chris Vervaet
A1
Journal Article
in
INTERNATIONAL JOURNAL OF PHARMACEUTICS
2011
Optimization of a pharmaceutical freeze-dried product and its process using an experimental design approach and innovative process analyzers
Thomas De Beer
M Wiggenhorn
A Hawe
JC Kasper
Ana Almeida
Thomas Quinten
W Friess
G Winter
Chris Vervaet
Jean Paul Remon
A1
Journal Article
in
TALANTA
2011
Raman spectroscopy for the in-line polymer-drug quantification and solid state characterization during a pharmaceutical hot-melt extrusion process
Lien Saerens
Lien Dierickx
B Lenain
Chris Vervaet
Jean Paul Remon
Thomas De Beer
A1
Journal Article
in
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
2011
Real-time image-based investigation of spheronization and drying phenomena using different pellet formulations
Anneleen Burggraeve
N Sandler
J Heinämäki
H Räikkönen
Jean Paul Remon
Chris Vervaet
Thomas De Beer
J Yliruusi
A1
Journal Article
in
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
2011
Sustained-release and swelling characteristics of xanthan gum/ethylcellulose-based injection moulded matrix tablets: in vitro and in vivo evaluation
Thomas Quinten
Thomas De Beer
FO Onofre
G Mendez-Montealvo
YJ Wang
Jean Paul Remon
Chris Vervaet
A1
Journal Article
in
JOURNAL OF PHARMACEUTICAL SCIENCES
2011
The use of silica nanoparticles for gas chromatographic separation
Na Na
Xianglan Cui
Thomas De Beer
Tingting Liu
Tingting Tang
Muhammad Sajid
Jin Ouyang
A1
Journal Article
in
JOURNAL OF CHROMATOGRAPHY A
2011
2010
A batch modelling approach to monitor a freeze-drying process using in-line Raman spectroscopy
Mafalda Cruz Sarraguça
Thomas De Beer
Chris Vervaet
Jean Paul Remon
João Almeida Lopes
A1
Journal Article
in
TALANTA
2010
Comparison and combination of spectroscopic techniques for the detection of counterfeit medicines
Pierre-Yves Sacré
Eric Deconinck
Thomas De Beer
Patricia Courselle
Roy Vancauwenberghe
Patrice Chiap
Jacques Crommen
Jacques O De Beer
A1
Journal Article
in
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
2010
Controlled crystallization of the lipophilic drug fenofibrate during freeze-drying: elucidation of the mechanism by in-line Raman spectroscopy
Hans de Waard
Thomas De Beer
Wouter LJ Hinrichs
Chris Vervaet
Jean Paul Remon
Henderik W Frijlink
A1
Journal Article
in
AAPS JOURNAL
2010
Evaluation of in-line spatial filter velocimetry as PAT monitoring tool for particle growth during fluid bed granulation
Anneleen Burggraeve
Tom Van Den Kerkhof
Mario Hellings
Jean Paul Remon
Chris Vervaet
Thomas De Beer
A1
Journal Article
in
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
2010
Raman spectroscopy for the analysis of drug products and drug manufacturing processes
Thomas De Beer
A4
Journal Article
in
EUROPEAN PHARMACEUTICAL REVIEW
2010
2009
Development of injection moulded matrix tablets based on mixtures of ethylcellulose and low-substituted hydroxypropylcellulose
Thomas Quinten
Yves Gonnissen
Els Adriaens
Thomas De Beer
Veerle Cnudde
Bert Masschaele
Luc Van Hoorebeke
J Siepmann
Jean Paul Remon
Chris Vervaet
A1
Journal Article
in
European Journal of Pharmaceutical Sciences
2009
Evaluation of injection moulding as a pharmaceutical technology to produce matrix tablets
Thomas Quinten
Thomas De Beer
Chris Vervaet
Jean Paul Remon
A1
Journal Article
in
European Journal of Pharmaceutics and Biopharmaceutics
2009
Importance of using complementary process analyzers for the process monitoring, analysis, and understanding of freeze drying
Thomas De Beer
M Wiggenhorn
R Veillon
C Debacq
Y Mayeresse
B Moreau
Anneleen Burggraeve
Thomas Quinten
W Friess
G Winter
et al.
A1
Journal Article
in
ANALYTICAL CHEMISTRY
2009
In-Line and Real-Time Process Monitoring of a Freeze Drying Process Using Raman and NIR Spectroscopy as Complementary Process Analytical Technology (PAT) Tools
Thomas De Beer
Pieter Vercruysse
Anneleen Burggraeve
Thomas Quinten
J. Ouyang
X. Zhang
Chris Vervaet
Jean Paul Remon
Willy Baeyens
A1
Journal Article
in
Journal of Pharmaceutical Sciences
2009
Influence of polyethylene glycol/polyethylene oxide on the release characteristics of sustained-release ethylcellulose mini-matrices produced by hot-melt extrusion: in vitro and in vivo evaluations
Ellen Verhoeven
Thomas De Beer
Etienne Schacht
G Van den Mooter
Jean Paul Remon
Chris Vervaet
A1
Journal Article
in
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
2009
Modeling drug release from hot-melt extruded mini-matrices with constant and non-constant diffusivities
Ellen Verhoeven
F Siepmann
Thomas De Beer
Denis Van Loo
G. Van den Mooter
Jean Paul Remon
J Siepmann
Chris Vervaet
A1
Journal Article
in
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
2009
Porous pellets as drug delivery system
An Cosijns
D Nizet
I Nikolakakis
Chris Vervaet
Thomas De Beer
F Siepmann
J Siepmann
B Evrard
Jean Paul Remon
A1
Journal Article
in
Drug Development and Industrial Pharmacy
2009
Reference database of Raman spectra of pharmaceutical excipients
Marleen De Veij
Peter Vandenabeele
Thomas De Beer
Jean Paul Remon
Luc Moens
A1
Journal Article
in
JOURNAL OF RAMAN SPECTROSCOPY
2009
2008
In-vitro and in-vivo evaluation of enteric-coated starch-based pellets prepared via extrusion/spheronisation
A DUKIC-OTT
Thomas De Beer
Jean Paul Remon
Willy Baeyens
P FOREMAN
Chris Vervaet
A1
Journal Article
in
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
2008
Influence of formulation and process parameters on the release characteristics of ethylcellulose sustained-release mini-matrices produced by hot-melt extrusion
Ellen Verhoeven
Thomas De Beer
G VAN DEN MOOTER
Jean Paul Remon
Chris Vervaet
A1
Journal Article
in
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
2008
Raman spectroscopy as a process analytical technology (PAT) tool for the in-line monitoring and understanding of a powder blending process
Thomas De Beer
C BODSON
B DEJAEGHER
B WALCZAK
Pieter Vercruysse
Anneleen Burggraeve
A LEMOS
L DELATTRE
YV HEYDEN
Jean Paul Remon
et al.
A1
Journal Article
in
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
2008
Simultaneous separation of eight beta-adrenergic drugs using titanium dioxide nanoparticles as additive in capillary electrophoresis
S Zhou
Y Wang
Thomas De Beer
Willy Baeyens
GT Fei
M Dilinuer
J Ouyang
A1
Journal Article
in
ELECTROPHORESIS
2008
2007
A strategy to implement a PAT system in a pharmaceutical production process: a case study: freeze-drying
Thomas De Beer
Willy Baeyens
Chris Vervaet
Jean Paul Remon
A2
Journal Article
in
STP PHARMA PRATIQUES
2007
Assessment of quality performance parameters for straight line calibration curves related to the spread of the abscissa values around their mean
Jacques De Beer
Thomas De Beer
Leo Goeyens
A1
Journal Article
in
Analytica Chimica Acta
2007
Implementation of a process analytical technology system in a freeze-drying process using Raman Spectroscopy for in-line process monitoring
Thomas De Beer
M ALLESO
Frederik Goethals
A COPPENS
Y VANDER HEYDEN
HL DE DIEGO
J RANTANEN
Francis Verpoort
Chris Vervaet
Jean Paul Remon
et al.
A1
Journal Article
in
ANALYTICAL CHEMISTRY
2007
Influence of particle size on the quantitative determination of salicylic acid in a pharmaceutical ointment using FT-Raman spectroscopy
Thomas De Beer
Willy Baeyens
Y VANDER HEYDEN
Jean Paul Remon
Chris Vervaet
Francis Verpoort
A1
Journal Article
in
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
2007
Investigation of patinas formed on Chinese bronzes using modern multianalytical techniques
S Hou
Y Li
M Xie
Thomas De Beer
Willy Baeyens
S Hu
J Ouyang
A1
Journal Article
in
SURFACE AND INTERFACE ANALYSIS
2007
Raman spectroscopic method for the determination of medroxyprogesterone acetate in a pharmaceutical suspension: validation of quantifying abilities, uncertainty assessment and comparison with the high performance liquid chromatography reference method
Thomas De Beer
Willy Baeyens
A VERMEIRE
D BROES
Jean Paul Remon
Chris Vervaet
A1
Journal Article
in
ANALYTICA CHIMICA ACTA
2007
Stimuli-responsive multilayered hybrid nanoparticle/polyelectrolyte capsules
Bruno De Geest
Andre Skirtach
Thomas De Beer
GB SUKHORUKOV
Lieven Bracke
Willy Baeyens
Jo Demeester
Stefaan De Smedt
A1
Journal Article
in
MACROMOLECULAR RAPID COMMUNICATIONS
2007
2006
Raman spectroscopy as a process analytical technology tool for the understanding and the quantitative in-line monitoring of the homogenization process of a pharmaceutical suspension
Thomas De Beer
Willy Baeyens
Jin Ouyang
Chris Vervaet
Jean Paul Remon
A1
Journal Article
in
ANALYST
2006
2004
Development and validation of a direct, non-destructive quantitative method for medroxyprogesterone acetate in a pharmaceutical suspension using FT-Raman spectroscopy
Thomas De Beer
GJ VERGOTE
Willy Baeyens
Jean Paul Remon
Chris Vervaet
Francis Verpoort
A1
Journal Article
in
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
2004
In-line monitoring of a pharmaceutical blending process using FT-Raman spectroscopy
GJ VERGOTE
Thomas De Beer
Chris Vervaet
Jean Paul Remon
Willy Baeyens
N DIERICX
Francis Verpoort
A1
Journal Article
in
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
2004
Use of polystyrene nanoparticles to enhance enantiomeric separation of propranolol by capillary electrophoresis with Hp-beta-CD as chiral selector
N NA
YP HU
Jin Ouyang
Willy Baeyens
Joris Delanghe
Thomas De Beer
A1
Journal Article
in
ANALYTICA CHIMICA ACTA
2004
2003
Optimization and validation of a micellar electrokinetic chromatographic method for the analysis of several angiotensin-II-receptor antagonists
Sandra Hillaert
Thomas De Beer
JO DE BEER
W VAN DEN BOSSCHE
A1
Journal Article
in
JOURNAL OF CHROMATOGRAPHY A
2003