Research Explorer

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Researcher

Sylviane Dewaele

Awards & Distinctions

33 Results

2025

Generation of a new Paneth cell-specific Cre-recombinase transgenic mouse line

Natalia Garcia GonzalezCharlotte WallaeysWendy ToussaintTino HochepiedSylviane DewaeleSomara De BeulRobin Van LokeJolien VandewalleSteven TimmermansClaude Libert

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

2023

Mutations in the histone methyltransferase Ezh2 drive context-dependent leukemia in Xenopus tropicalis

Dieter TulkensMarthe BoelensThomas NaertMarjolein CarronSuzan DemuynckSylviane DewaeleGert Van IsterdaelDavid CreytensTim PietersSteven Goossens et al.

A1 Journal Article in LEUKEMIA

The impact of hepatocyte-specific deletion of hypoxia-inducible factors on the development of polymicrobial sepsis with focus on GR and PPARα function

Tineke VanderhaeghenSteven TimmermansMelanie EggermontDeepika WattsJolien VandewalleCharlotte WallaeysLouise NuyttensJoyca De TemmermanTino HochepiedSylviane Dewaele et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

2022

Point mutation I634A in the glucocorticoid receptor causes embryonic lethality by reduced ligand binding

Steven TimmermansNicolette J.D. VerhoogKelly Van LooverenSylviane DewaeleTino HochepiedMelanie EggermontBarbara GilbertAnne Boerema-de MunckTineke VanderhaeghenJoke Vanden Berghe et al.

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Reprogramming of glucocorticoid receptor function by hypoxia

Tineke VanderhaeghenSteven TimmermansDeepika WattsVille PaakinahoMelanie EggermontJolien VandewalleCharlotte WallaeysLise Van WyngeneKelly Van LooverenLouise Nuyttens et al.

A1 Journal Article in EMBO REPORTS

2021

Combined glucocorticoid resistance and hyperlactatemia contributes to lethal shock in sepsis

Jolien VandewalleSteven TimmermansVille PaakinahoLies VancraeynestLiza DewyseTineke VanderhaeghenCharlotte WallaeysLise Van WyngeneKelly Van LooverenLouise Nuyttens et al.

A1 Journal Article in CELL METABOLISM

ZBTB32 performs crosstalk with the glucocorticoid receptor and is crucial in glucocorticoid responses to starvation

Lise Van WyngeneTineke VanderhaeghenIoanna PettaSteven TimmermansKatrien CorbeelsBart Van der SchuerenJolien VandewalleKelly Van LooverenCharlotte WallaeysMelanie Eggermont et al.

A1 Journal Article in ISCIENCE

2020

Zinc inhibits lethal inflammatory shock by preventing microbe-induced interferon signature in intestinal epithelium

Jolien SouffriauSteven TimmermansTineke VanderhaeghenCharlotte WallaeysKelly Van LooverenLindsy AelbrechtSylviane DewaeleJolien VandewalleEvy GoossensSerge Verbanck et al.

A1 Journal Article in EMBO MOLECULAR MEDICINE

2019

Do people living with HIV experience greater age advancement than their HIV-negative counterparts?

Davide De FrancescoFerdinand W WitAlexander BürkleSebastian OehlkeNeeltje A KootstraAlan WinstonClaudio FranceschiPaolo GaragnaniChiara PirazziniClaude Libert et al.

A1 Journal Article in AIDS

TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile

Karen DendonckerSteven TimmermansJolien VandewalleMelanie EggermontJoanna LempiäinenVille PaakinahoEvelien Van HammeSylviane DewaeleSofie VandevyverMarlies Ballegeer et al.

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Validation of a novel multivariate method of defining HIV-associated cognitive impairment

Jonathan UnderwoodDavide de FrancescoJames H ColeMatthan WA CaanRosan A van ZoestBen A SchmandDavid J SharpCaroline A SabinPeter ReissAlan Winston et al.

A1 Journal Article in OPEN FORUM INFECTIOUS DISEASES

2017

High cellular monocyte activation in people living with human immunodeficiency virus on combination antiretroviral therapy and lifestyle-matched controls is associated with greater inflammation in cerebrospinal fluid

Thijs BooimanFerdinand W WitIrma MaurerDavide De FrancescoCaroline A SabinAgnes M HarskampMaria PrinsPaolo GaragnaniChiara PirazziniClaudio Franceschi et al.

A1 Journal Article in OPEN FORUM INFECTIOUS DISEASES

Increased brain-predicted aging in treated HIV disease

James H ColeJonathan UnderwoodMatthan WA CaanDavide De FrancescoRosan A van ZoestRobert LeechFerdinand WNM WitPeter PortegiesGert J GeurtsenBen A Schmand et al.

A1 Journal Article in NEUROLOGY

2016

Development and validation of a small single-domain antibody that effectively inhibits matrix metalloproteinase 8

Delphine DemeestereEline DejonckheereSophie SteelandPaco HulpiauJurgen HaustraeteNick DevoogdtRielana WichertChristoph Becker-PaulyElien Van WonterghemSylviane Dewaele et al.

A1 Journal Article in MOLECULAR THERAPY

2015

N-Glycomic changes in serum proteins in type 2 diabetes mellitus correlate with complications and with metabolic syndrome parameters

Roberto TestaValerie VanhoorenAnna Rita BonfigliMassimo BoemiFabiola OlivieriAntonio CerielloStefano GenoveseLiana SpazzafumoVincenzo BorelliMaria Giulia Bacalini et al.

A1 Journal Article in PLOS ONE

N-glycome profile levels relate to silent brain infarcts in a cohort of hypertensives

Andrea Vilar-BerguaIolanda Riba-LlenaValerie VanhoorenSylviane DewaeleClaude LibertAnna PenalbaJoan MontanerPilar Delgado

A1 Journal Article in JOURNAL OF THE AMERICAN HEART ASSOCIATION

2013

Mice overexpressing β-1,4-galactosyltransferase I are resistant to TNF-induced inflammation and DSS-induced colitis

Valerie VanhoorenRoosmarijn VandenbrouckeSylviane DewaeleEvelien Van HammeJody HaighTino HochepiedClaude Libert

A1 Journal Article in PLOS ONE

2012

Alteration of liver N-glycome in patients with hepatocellular carcinoma

Ling WangValerie VanhoorenSylviane DewaeleXue-En LiuClaude LibertFeng-Min LuHui ZuangCuiying Chen

A2 Journal Article in OPEN JOURNAL OF GASTROENTEROLOGY

Altered desialylated plasma N-glycan profile in patients with non-small cell lung carcinoma

Babett BartlingValerie VanhoorenSylviane DewaeleClaude LibertHans-Stefan HofmannJohannes HaertingSebastian NudingRolf-Edgar SilberAndreas SimmCuiying Chen

A1 Journal Article in CANCER BIOMARKERS

2011

Alteration in N-glycomics during mouse aging: a role for FUT8

Valerie VanhoorenSylviane DewaeleMakoto Kuro-oNaoyuki TaniguchiLaurent DolléLeo A van GrunsvenEvgenia MakrantonakiChristos C ZouboulisCuiying ChenClaude Libert

A1 Journal Article in AGING CELL

2010

Alteration of N-glycome in diethylnitrosamine-induced hepatocellular carcinoma mice: a non-invasive monitoring tool for liver cancer

Xue-en LiuSylviane DewaeleValerie VanhoorenYe-Dong FanLing WangJacques Van HuysseHui ZhuangRoland ContrerasClaude LibertCuiying Chen

A1 Journal Article in LIVER INTERNATIONAL

Altered serum N-glycomics in chronic hepatitis B patients

Hong-Lian GuiChung-Fang GaoHui WangXue-En LiuQing XieSylviane DewaeleLing WangHui ZhuangRoland ContrerasClaude Libert et al.

A1 Journal Article in LIVER INTERNATIONAL

Altered serum glycomics in Alzheimer disease: a potential blood biomarker?

Cuiying ChenSebastiaan EngelborghsSylviane DewaeleNathalie Le BastardJean-Jacques MartinValerie VanhoorenClaude LibertPeter Paul De Deyn

A1 Journal Article in REJUVENATION RESEARCH

Serum N-glycan profile shift during human ageing

Valerie VanhoorenSylviane DewaeleClaude LibertSebastiaan EngelborghsPeter Paul De DeynOlivier ToussaintFlorence Debacq-ChainiauxMichel PoulainYouri GlupczynskiClaudio Franceschi et al.

A1 Journal Article in EXPERIMENTAL GERONTOLOGY

Serum N-glycome biomarker for monitoring development of DENA-induced hepatocellular carcinoma in rat

Meng FangSylviane DewaeleYun-peng ZhaoPeter StarkelValerie VanhoorenYue-ming ChenXin JiMing LuoBao-mu SunYves Horsmans et al.

A1 Journal Article in MOLECULAR CANCER

2008

Fishing for lectins from diverse sequence libraries by yeast surface display - An exploratory study

Stefan RyckaertNico CallewaertPieter JacobsSylviane DewaeleIsabelle DewerteRoland Contreras

A1 Journal Article in GLYCOBIOLOGY

Over-expression of heat shock protein 70 in mice is associated with growth retardation, tumor formation, and early death

Valerie VanhoorenXue-En LiuLiesbeth DesmyterYe-Dong FanLieve VanwalleghemWim Van MolleSylviane DewaeleMarleen PraetRoland ContrerasClaude Libert et al.

A1 Journal Article in REJUVENATION RESEARCH

2007

N-glycomic changes in hepatocellular carcinoma patients with liver cirrhosis induced by hepatitis B virus

Xueen LiuLiesbeth DesmyterCF GAOWouter LaroySylviane DewaeleValerie VanhoorenL WANGH ZHUANGNico CallewaertClaude Libert et al.

A1 Journal Article in HEPATOLOGY

N-glycomic changes in serum proteins during human aging

Valerie VanhoorenLiesbeth DesmyterXueen LiuM CARDELLIC FRANCESCHIA FEDERICOClaude LibertWouter LaroySylviane DewaeleRoland Contreras et al.

A1 Journal Article in REJUVENATION RESEARCH

Nonclassical export pathway: overexpression of NCE102 reduces protein and DNA damage and prolongs lifespan in an SGS1 deficient Saccharomyces cerevisiae

Liesbeth DesmyterJan VerstraelenSylviane DewaeleClaude LibertRoland ContrerasCuiying Chen

A1 Journal Article in BIOGERONTOLOGY

2005

Glycoprofiling of N-linked serum protein: an aging biomarker?

Cuiying ChenL DESMYTERW VAN MOLLEWouter LaroyAnnelies Van HeckeSylviane DewaeleA FEDERICOClaude LibertRoland Contreras

2004

Expression of the human ferritin light chain in a frataxin mutant yeast affects ageing and cell death

Liesbeth DesmyterSylviane DewaeleRieka ReekmansT NYSTROMRoland ContrerasCuiying Chen

A1 Journal Article in EXPERIMENTAL GERONTOLOGY

2003

A high-throughput screening system for genes extending life-span

Cuiying ChenSylviane DewaeleBart BraeckmanLiesbeth DesmyterJan VerstraelenGaetan BorgonieJacques VanfleterenRoland Contreras

A1 Journal Article in EXPERIMENTAL GERONTOLOGY