Research Explorer

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Researcher

Sylvia Van Dorpe

Awards & Distinctions

41 Results

2014

The effect of prolonged exposure to morphine on canine cerebral 5-HT2A receptors measured with 123I-R91150 SPECT

Antita AdriaensIngeborgh PolisSimon VermeireTim WaelbersSiska CroubelsLuc DuchateauSylvia Van DorpeJos EerselsBart De SpiegeleerKathelijne Peremans

A1 Journal Article in EUROPEAN NEUROPSYCHOPHARMACOLOGY

2013

Reversed-phase fused-core HPLC modeling of peptides

Matthias D'HondtBert GevaertSofie StalmansSylvia Van DorpeEvelien WynendaeleKathelijne PeremansChristian BurvenichBart De Spiegeleer

A2 Journal Article in JOURNAL OF PHARMACEUTICAL ANALYSIS

2012

Analytical characterization of the blood-brain barrier transport of peptides

Sylvia Van DorpeBart De Spiegeleer

Api88 is a novel antibacterial designer peptide to treat systemic infections with multidrug-resistant Gram-negative pathogens

Patricia CzihalDaniel KnappeStefanie FritscheMichael ZahnNicole BertholdStefania PiantavignaUwe MüllerSylvia Van DorpeNicole HerthAnnegret Binas et al.

A1 Journal Article in ACS CHEMICAL BIOLOGY

Blood-brain barrier modelling of bioactive peptides

Bart De SpiegeleerMatthias D'HondtSofie StalmansSylvia Van Dorpe

Brainpeps: the blood-brain barrier peptide database

Sylvia Van DorpeAntoon BronselaerJoachim NielandtSofie StalmansEvelien WynendaeleKurt AudenaertChristophe Van De WieleChristian BurvenichKathelijne PeremansHung Hsuchou et al.

A1 Journal Article in BRAIN STRUCTURE & FUNCTION

In vitro metabolic stability of iodinated obestatin peptides

Bart De SpiegeleerSylvia Van DorpeValentijn VergoteEvelien WynendaeleEwald PauwelsChristophe Van De WielePablo Garcia-SolisJuan Carlos Solis-Sainz

A1 Journal Article in PEPTIDES

Stability of extemporaneously prepared cytarabine, methotrexate sodium, and methylprednisolone sodium succinate

Matthias D'HondtElien VangheluweSylvia Van DorpeJente BoonenTieneke BautersBRIGITTE PELFRENEJohan VandenbrouckeHugo RobaysBart De Spiegeleer

A1 Journal Article in AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY

The influence of chronic morphine on the canine cerebral 5-HT2A receptor availability measured with SPECT

Antita AdriaensIngeborgh PolisSimon VermeireEva VandermeulenTim WaelbersJos EerselsAndré DobbeleirLuc DuchateauSylvia Van DorpeBart De Spiegeleer et al.

The influence of morphine on cerebral 5-HT2A receptor availability in dogs: a SPECT study

Antita AdriaensIngeborgh PolisSimon VermeireTim WaelbersLuc DuchateauStanislas SysSylvia Van DorpeJos EerselsBart De SpiegeleerKathelijne Peremans

A1 Journal Article in JOURNAL OF NUCLEAR MEDICINE

Variation of the net charge, lipophilicity, and side chain flexibility in Dmt¹-DALDA: effect on opioid activity and biodistribution

Alexandre NovoaSylvia Van DorpeEvelien WynendaeleMariana SpeteaNathalie BrackeSofie StalmansCecilia BettiNga N ChungCarole LemieuxJohannes Zuegg et al.

A1 Journal Article in JOURNAL OF MEDICINAL CHEMISTRY

2011

ADME behaviour of some Dmt-DALDA-peptide derivatives

Sylvia Van DorpeIris VandenbroeckEvelien WynendaeleMathieu VerbekenAlexandre NovoaDirk TourwéSteven BalletBart De Spiegeleer

Blood-brain barrier and ADME properties of selected DALDA-peptide derivatives

Sylvia Van DorpeEvelien WynendaeleChristian BurvenichAlexandre NovoaDirk TourwéSteven BalletBart De Spiegeleer

Blood-brain barrier characteristics of opioid peptides

Sylvia Van DorpeChristophe Van De WieleAntita AdriaensIngeborgh PolisKathelijne PeremansBart De Spiegeleer

Desirability function combining metabolic stability and functionality of peptides

Sylvia Van DorpeAntita AdriaensSimon VermeireIngeborgh PolisKathelijne PeremansBart De Spiegeleer

A1 Journal Article in JOURNAL OF PEPTIDE SCIENCE

Dry heat stress stability evaluation of casein peptide mixture

Matthias D'HondtWim DemaréSylvia Van DorpeEvelien WynendaeleChristian BurvenichKathelijne PeremansBart De Spiegeleer

A1 Journal Article in FOOD CHEMISTRY

Purity profiling of peptide drugs

Sylvia Van DorpeMathieu VerbekenEvelien WynendaeleBart De Spiegeleer

A2 Journal Article in JOURNAL OF BIOANALYSIS AND BIOMEDICINE

Stability-indicating HPLC-DAD/UV-ESI/MS impurity profiling of the anti-malarial drug lumefantrine

Mathieu VerbekenSultan Suleman WegaBram BaertElien VangheluweSylvia Van DorpeChristian BurvenichLuc DuchateauFrans H JansenBart De Spiegeleer

A1 Journal Article in MALARIA JOURNAL

Structural modification and biological evaluation of Dmt1-DALDA analogues

Alexandre NovoaSylvia Van DorpeEvelien WynendaeleNga ChungCarole LemieuxPeter W SchillerDirk TourwéBart De SpiegeleerSteven Ballet

2010

Analytical characterization and comparison of the blood-brain barrier permeability of eight opioid peptides

Sylvia Van DorpeAntita AdriaensIngeborgh PolisKathelijne PeremansJan Van BocxlaerBart De Spiegeleer

A1 Journal Article in PEPTIDES

Bioactive peptides as potential new drugs: from analytics to tissue bath functionality

Mathieu VerbekenSylvia Van DorpeRomain LefebvreBart De Spiegeleer

Chemical quality control of peptide functionality testing in tissue baths

Mathieu VerbekenSylvia Van DorpeRomain LefebvreBart De Spiegeleer

Comparative drugability evaluation of MOR opioid peptides in functional brain research

Bart De SpiegeleerSylvia Van DorpeOlga JedlickovaAntita AdriaensSimon VermeireIngeborgh PolisKathelijne Peremans

Functional differences of iodinated obestatin peptides: in vitro metabolic stability profile

Sylvia Van DorpeIngeborg WallezBart De Spiegeleer

Functional drugability of MOR-opioid peptides through desirability

Sylvia Van DorpeOlga JedlickovaAntita AdriaensTim WaelbersSimon VermeireIngeborgh PolisKathelijne PeremansBart De Spiegeleer

HPLC-MS characterisation of chelate modified somatropin

Evelien WynendaeleEwald PauwelsSylvia Van DorpeValentijn VergoteChristophe Van De WieleBart De Spiegeleer

Hydrophilic interaction LC of peptides: columns comparison and clustering

Sylvia Van DorpeValentijn VergoteAdel PezeshkiChristian BurvenichKathelijne PeremansBart De Spiegeleer

A1 Journal Article in JOURNAL OF SEPARATION SCIENCE

LC-MS quality control of modified pharmaceutical proteins : the somatropin case

Evelien WynendaeleEwald PauwelsChristophe Van De WieleSylvia Van DorpeBart De Spiegeleer

Morphine decreases 5-HT2A receptor binding measured with SPECT in the canine frontal cortex

Antita AdriaensSimon VermeireTim WaelbersLuc DuchateauStanislas SysAndré DobbeleirSylvia Van DorpeJ EerselsBart De SpiegeleerKurt Audenaert et al.

Quality analysis of salmon calcitonin in a polymeric bioadhesive pharmaceutical formulation: sample preparation optimization by DOE

Matthias D'HondtSylvia Van DorpeEls MehuysDieter DeforceBart De Spiegeleer

A1 Journal Article in JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

The influence of morphine on 5-HT2A receptor availability using SPECT: a preliminary study in dogs

Antita AdriaensSimon VermeireTim WaelbersLuc DuchateauStanislas SysSylvia Van DorpeJos EerselsBart De SpiegeleerKathelijne PeremansIngeborgh Polis

The metabolisation of different iodinated peptide species

Bart De SpiegeleerSylvia Van DorpeEwald Pauwels

The metabolisation of different iodinated peptide species

Bart De SpiegeleerSylvia Van DorpeEwald Pauwels

2009

Adsorption of peptides at the sample drying step: influence of solvent evaporation technique, vial material and solution additive

Adel PezeshkiValentijn VergoteSylvia Van DorpeBram BaertChristian BurvenichAlexander PopkovBart De Spiegeleer

A1 Journal Article in JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Analytical characterization of the BBB functionality of the opioid-peptides EM-1, EM-2 and CTAP.

Sylvia Van DorpeNathalie PintelonAntita AdriaensIngeborgh PolisKathelijne PeremansWeihong PanChristian BurvenichBart De Spiegeleer

Development of peptide receptor binding assays: methods to avoid false negatives

Valentijn VergoteSylvia Van DorpeMathieu VerbekenChristian BurvenichChristophe Van De WieleWilliam BanksBart De Spiegeleer

A1 Journal Article in REGULATORY PEPTIDES

2008

Development of system suitability tests for in vitro skin integrity control: impedance and capacitance.

Bart De SpiegeleerBram BaertValentijn VergoteSylvia Van Dorpe

In vitro metabolic stability of obestatin: Kinetics and identification of cleavage products

Valentijn VergoteSylvia Van DorpeKathelijne PeremansChristian BurvenichBart De Spiegeleer

A1 Journal Article in PEPTIDES

Inhibiting protease-activity in peptidomics: strategies during sampling and receptor studies

Valentijn VergoteAdel PezeshkiSylvia Van DorpeChristian BurvenichBart De Spiegeleer

Pharmaceutical drugability of peptides

Bart De SpiegeleerValentijn VergoteSylvia Van DorpeBram BaertKurt AudenaertChristophe Van De WieleKathelijne PeremansChristian Burvenich

Screening methodology for chemical and metabolic stability of potential peptide drugs

Bart De SpiegeleerValentijn VergoteAdel PezeshkiSylvia Van DorpeBram BaertChristian Burvenich