Research Explorer

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Researcher

Sven Eyckerman

Publications & Research Data

Awards & Distinctions

119 Results

2026

Multi-omics profiling reveals molecular pathways involved in RNF216-mediated neurodegeneration

Axelle VersavelLauren VersluysLotte KeymeulenMarthe De BoeckAnne SiebenJo Van DorpePatrick SantensSven EyckermanFrancis ImpensBart Dermaut et al.

Multi-omics profiling reveals molecular pathways involved in RNF216-mediated neurodegeneration

Axelle VersavelLauren VersluysLotte KeymeulenMarthe De BoeckJo Van DorpeAnne SiebenSven EyckermanFrancis ImpensBart DermautElke Bogaert

2025

A 96‐well ultrafiltration approach for the high‐throughput proteome analysis of extracellular vesicles isolated from conditioned medium

Jarne PauwelsTessa Van de SteeneFreya De MuyerDanaë De PauwFemke BaekeSven EyckermanKris Gevaert

A1 Journal Article in JOURNAL OF EXTRACELLULAR VESICLES

BioID reveals that NR2E3 mediates transcriptional repression through the AP-1 complex

dr. Edith De BruyckerOlivier ZwaenepoelManon BouckaertGeorgios MoschonasDelphine De SutterLouis DelhayeFrauke CoppietersSven EyckermanJan GettemansElfride De Baere

CCR1 inhibition sensitizes multiple myeloma cells to glucocorticoid therapy

Bert LuyckxMaaike Van TrimpontFien DeclerckEleni StaessensAnnick VerheeSara T'SasSven EyckermanFritz OffnerPieter Van VlierbergheSteven Goossens et al.

A1 Journal Article in PHARMACOLOGICAL RESEARCH

Filter-aided extracellular vesicle enrichment (FAEVEr) for proteomics

Jarne PauwelsTessa Van de SteeneJana Van de VeldeFreya De MuyerDanaë De PauwFemke BaekeSven EyckermanKris Gevaert

A1 Journal Article in MOLECULAR & CELLULAR PROTEOMICS

Filter-aided extracellular vesicle enrichment towards high-throughput proteomics for biomarker discovery

Jarne PauwelsKris GevaertSven Eyckerman

Getting close to RNF216 : proximity labeling reveals links between nuclear condensates, splicing and neurodegeneration

Lauren VersluysAxelle VersavelLotte KeymeulenAnne SiebenNika SchuermansElisabeth Mondragon RezolaPatrick SantensJo Van DorpeFrancis ImpensSven Eyckerman et al.

Myxovirus resistance (Mx) interacting proteins

Georgios MoschonasXavier SaelensSven Eyckerman

Proximity map for p53 unveils a strong link with PML Nuclear Bodies in HEK293 cells

Edith De BruyckerGiel VandemoorteleDelphine De SutterGeorge MoschonasSven Eyckerman

Rapid assay optimization by plug-and-play MAPPIT

Stefanie MaesLouis DelhayeRobin CooremanEline SoetensAnnick VerheeDelphine De SutterTessa Van de SteeneLong NguyenDominique AudenaertXavier Saelens et al.

Stress attenuation by the adrenergic-specific lncRNA NESPR prevents cell death in neuroblastoma cells

Louis DelhayeDries RombautEric de Bony de LavergneEva D'haeneTiago França BrazaoLisa DepestelBieke DecaestekerStéphane Van HaverRamiro MartinezLaudonia Lidia Dipalo et al.

TurboID proximity interactome mapping reveals NR2E3 association with AP-1 and retinal developmental complexes

Edith De BruyckerOlivier ZwaenepoelGeorgios MoschonasDelphine De SutterEva D'haeneCharlotte MattonLaure VandeveldeJULIE VAN DE VELDEQuinten MahieuSara Dufour et al.

Unravelling the proxisome of photoreceptor-specific nuclear receptor NR2E3 reveals a potential molecular link between transcriptional regulation and splicing in human retina

Edith De BruyckerOlivier ZwaenepoelManon BouckaertGeorgios MoschonasDelphine De SutterLouis DelhayeFrauke CoppietersSven EyckermanJan GettemansElfride De Baere

Virotrap Reveals <i>Salmonella</i> SopB as A Ubiquitinated Cargo for Host ESCRT-0

Margaux De MeyerAnnick VerheeHanna GrzesikDelphine De SutterJon HuygheLouis DelhayeTessa Van de SteeneIgor FijalkowskiVeronique JonckheereLeander Meuris et al.

Widespread DNA off-targeting confounds studies of RNA chromatin occupancy

Micah Jonathan GoldrichLouis DelhayeSarah-Lee BekaertBieke DecaestekerFilip Van NieuwerburghFranki SpelemanSven EyckermanPieter MestdaghIgor Ulitsky

2024

A virotrap expedition into salmonella's effector-host landscape

Margaux De MeyerSven Eyckerman

Activation of goblet-cell stress sensor IRE1β is controlled by the mucin chaperone AGR2

Eva ClootsPhaedra GuilbertMathias ProvostLisa NeidhardtEvelien Van De VeldeFarzaneh FayazpourDelphine De SutterSavvas SavvidesSven EyckermanSophie Janssens

A1 Journal Article in EMBO JOURNAL

Deciphering the ghost proteome in ovarian cancer cells by deep proteogenomic characterization

Diego Fernando Garcia del RioMehdi DerhourhiAmelie BonnefondSébastien LeblancNoé GuilloyXavier RoucouSven EyckermanKris GevaertMichel SalzetTristan Cardon

A1 Journal Article in CELL DEATH & DISEASE

Leveraging a self-cleaving peptide for tailored control in proximity labeling proteomics

Louis DelhayeGeorgios MoschonasDaria FijalkowskaAnnick VerheeDelphine De SutterTessa Van de SteeneMargaux De MeyerHanna GrzesikLaura Van MoortelKarolien De Bosscher et al.

A2 Journal Article in CELL REPORTS METHODS

MX2 forms nucleoporin-comprising cytoplasmic biomolecular condensates that lure viral capsids

Georgios MoschonasLouis DelhayeRobin CooremanFranziska HuesersAnayat BhatZoi StylianidouElien De BousserLaure De PryckHanna GrzesikDelphine De Sutter et al.

A1 Journal Article in CELL HOST & MICROBE

Selective modulation of the human glucocorticoid receptor compromises GR chromatin occupancy and recruitment of p300/CBP and the Mediator complex

Laura Van MoortelAnnick VerheeJonathan ThommisRené HoutmanDiana MelchersLouis DelhayeChloé Van LeeneMadeleine HellemansKris GevaertSven Eyckerman et al.

A1 Journal Article in MOLECULAR & CELLULAR PROTEOMICS

Unravelling the interactome of nuclear receptors through proximity dependent biotin labelling

Edith De BruyckerOlivier ZwaenepoelManon BouckaertLaure VandeveldeDelphine De SutterLouis DelhayeFrauke CoppietersSven EyckermanElfride De BaereJan Gettemans

2023

A decoupled Virotrap approach to study the interactomes of N-terminal proteoforms

Annelies BogaertTessa Van de SteeneMarnik VuylstekeSven EyckermanKris Gevaert

Bookchapter in Methods in enzymology

Cornification of keratinocytes is associated with differential changes in the catalytic activity and the immunoreactivity of transglutaminase-1

Marta SurbekTessa Van de SteeneAttila Placido SachslehnerBahar GolabiJohannes GrissSven EyckermanKris GevaertLeopold Eckhart

A1 Journal Article in SCIENTIFIC REPORTS

Deep mutational scanning of proteins in mammalian cells

Stefanie MaesNick DeploeyFrank PeelmanSven Eyckerman

A2 Journal Article in CELL REPORTS METHODS

Employing non-targeted interactomics approach and subcellular fractionation to increase our understanding of the ghost proteome

Diego Fernando Garcia del RioTristan CardonSven EyckermanIsabelle FournierAmelie BonnefondKris GevaertMichel Salzet

A1 Journal Article in ISCIENCE

Endogenous TOM20 proximity labeling : a Swiss-knife for the study of mitochondrial proteins in human cells

Sébastien MeurantLorris MaucletMarc DieuThierry ArnouldSven EyckermanPatricia Renard

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

mTOR inhibition enhances delivery and activity of antisense oligonucleotides in uveal melanoma cells

Shanna DewaeleLouis DelhayeBoel De PaepeBram BogaertRamiro MartinezJasper AnckaertNurten YigitJustine NuytensRudy Van CosterSven Eyckerman et al.

A1 Journal Article in NUCLEIC ACID THERAPEUTICS

N-terminal proteoforms may engage in different protein complexes

Annelies BogaertDaria FijalkowskaAn StaesTessa Van de SteeneMarnik VuylstekeCharlotte StadlerSven EyckermanKerstin SpirohnTong HaoMichael A Calderwood et al.

A1 Journal Article in LIFE SCIENCE ALLIANCE

Studying protein complexes for assessing the function of ghost proteins (ghost in the cell)

Diego Fernando Garcia del RioMichel SalzetKris GevaertAmélie BonnefondSven Eyckerman

Virotrap : trapping protein complexes in virus-like particles

Georgios MoschonasMargaux De MeyerDelphine De SutterEvy TimmermanPetra Van DammeSven Eyckerman

Bookchapter in Mass spectrometry-based proteomics

2022

An unexpected encounter : respiratory syncytial virus nonstructural protein 1 interacts with mediator subunit MED25

Tessa Van RoyenKoen SedeynGeorgios MoschonasWendy ToussaintM VuylstekeDelphi Van HaverFrancis ImpensSven EyckermanIrma LemmensJan Tavernier et al.

A1 Journal Article in JOURNAL OF VIROLOGY

Engineered tracrRNA for enabling versatile CRISPR-dCas9-based biosensing concepts

Saba SafdarSeppe DriesenKaren LeirsDelphine De SutterSven EyckermanJeroen LammertynDragana Spasic

A1 Journal Article in BIOSENSORS & BIOELECTRONICS

Functional characterization of RNF213 as newly discovered ISG15 sensor during infection

Lia MartinaFrancis ImpensSven Eyckerman

Highly flexible and accurate serial picoinjection in droplets by combined pressure and flow rate control

Jolien BreukersHannah Op de BeeckIene RuttenMontserrat López FernándezSven EyckermanJeroen Lammertyn

A1 Journal Article in LAB ON A CHIP

Mass spectrometry and the cellular surfaceome

Jarne PauwelsDaria FijalkowskaSven EyckermanKris Gevaert

A1 Journal Article in MASS SPECTROMETRY REVIEWS

Novel assays monitoring direct glucocorticoid receptor protein activity exhibit high predictive power for ligand activity on endogenous gene targets

Laura Van MoortelJonathan ThommisBrecht MaertensAn StaesDorien ClarisseDelphine De SutterClaude LibertOnno C. MeijerSven EyckermanKris Gevaert et al.

A1 Journal Article in BIOMEDICINE & PHARMACOTHERAPY

Orthogonal proteomics methods to unravel the HOTAIR interactome

Louis DelhayeEdith De BruyckerPieter-Jan VoldersDaria FijalkowskaDelphine De SutterSven DegroeveLennart MartensPieter MestdaghSven Eyckerman

Orthogonal proteomics methods to unravel the HOTAIR interactome

Louis DelhayeEdith De BruyckerPieter-Jan VoldersDaria FijalkowskaDelphine De SutterSven DegroeveLennart MartensPieter MestdaghSven Eyckerman

A1 Journal Article in SCIENTIFIC REPORTS

Pinpointing molecular mechanisms of long non-coding RNAs : at the crossroads of biochemistry and genetics

Louis DelhayeSven EyckermanPieter Mestdagh

Proteomics-based characterization of ISG15 signaling in host defense mechanisms against microbial infection

Fabien Henri TheryFrancis ImpensSven Eyckerman

RRM2 enhances MYCN driven neuroblastoma formation and acts as a synergistic target with CHK1 inhibition

Lisa DepestelCarolina de Carvalho NunesLiselot MusIris NelenLouis DelhayeKaylee KellerVolodimir OlexioukFanny De VloedEllen SandersAline Eggermont et al.

RRM2 enhances MYCN-driven neuroblastoma formation and acts as a synergistic target with CHK1 inhibition

Carolina de Carvalho NunesLisa DepestelLiselot MusKaylee M. KellerLouis DelhayeAmber LouwagieMuhammad RishfiAlex WhaleNeesha KaraSimon R. Andrews et al.

A1 Journal Article in SCIENCE ADVANCES

The adrenergic-specific long non-coding RNA NESPR controls survival of neuroblastoma cells

Louis DelhayeEric de Bony de LavergneDries RombautLim Fang QiBieke DecaestekerLisa DepestelAmber LouwagieEva D'haenePieter-Jan VoldersNurten Yigit et al.

The long non-coding RNA SAMMSON is essential for uveal melanoma cell survival

Shanna DewaeleLouis DelhayeBoel De PaepeEric de Bony de LavergneJilke De WildeKatrien VanderheydenJasper AnckaertNurten YigitJustine NuytensEveline Vanden Eynde et al.

A1 Journal Article in ONCOGENE

The long non-coding RNA SAMMSON is essential for uveal melanoma cell survival (Sept, 10.1038/s41388-021-02006-x, 2021)

Shanna DewaeleLouis DelhayeBoel De PaepeEric James de BonyJilke De WildeKatrien VanderheydenJasper AnckaertNurten YigitJustine NuytensEveline Vanden Eynde et al.

2021

Capturing salmonella SspH2 host targets in virus-like particles

Margaux De MeyerIgor FijalkowskiVeronique JonckheereDelphine De SutterSven EyckermanPetra Van Damme

A1 Journal Article in FRONTIERS IN MEDICINE

FO‐SPR biosensor calibrated with recombinant extracellular vesicles enables specific and sensitive detection directly in complex matrices

Yagmur YildizhanVenkata Suresh VajralaEdward GeeurickxCharles DeclerckNevena DuskunovicDelphine De SutterSam NoppenFilip DelportDominique ScholsJohannes V. Swinnen et al.

A1 Journal Article in JOURNAL OF EXTRACELLULAR VESICLES

IRE1 beta does not affect mucus secretion during allergic asthma development in a house dust mite murine model

Eva ClootsNincy DebeufKim DeswarteFarzaneh FayazpourManon VanheerswynghelsCaroline De WolfEvelien Van de VeldeHamida HammadBart LambrechtSven Eyckerman et al.

A1 Journal Article in ALLERGY

Loss-of-function mutations in TRAF7 and KLF4 cooperatively activate RAS-like GTPase signaling and promote meningioma development

P NajmP ZhaoM SteklovRN SewduthMF BaiettiS PandolfiN CriemB LechatTeresa MaiaDelphi Van Haver et al.

A1 Journal Article in CANCER RESEARCH

Proteome profiling of RNF213 depleted cells reveals nitric oxide regulator DDAH1 antilisterial activity

Lia MartinaCaroline AsselmanFabien Henri TheryKatie BoucherLouis DelhayeTeresa MaiaBart DermautSven EyckermanFrancis Impens

A1 Journal Article in FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY

Ring finger protein 213 assembles into a sensor for ISGylated proteins with antimicrobial activity

Fabien Henri TheryLia MartinaCaroline AsselmanHeidi RepoY ZhangKoen SedeynGeorgios MoschonasC BredowQW TeoJ Zhang et al.

A1 Journal Article in NATURE COMMUNICATIONS

The functional annotation and exploration the SOX11 enhanceosome

Amber LouwagieBieke DecaestekerLouis DelhayeEva D'haeneEric de Bony de LavergneVolodimir OlexioukSarah VergultRogier VersteegJan KosterJohan van Nes et al.

The ins and outs of IRE1β signaling : the role of IRE1β in mucosal homeostasis

Eva ClootsSven EyckermanSophie Janssens

2020

IRE1β negatively regulates IRE1α signaling in response to endoplasmic reticulum stress

Michael J. GreyEva ClootsMariska S. SimpsonNicole LeDucYevgeniy V. SerebrenikHeidi De LucaDelphine De SutterPhi LuongJay R. ThiagarajahAdrienne W. Paton et al.

A1 Journal Article in JOURNAL OF CELL BIOLOGY

Long noncoding RNA SILC1 is an upstream regulator of SOX11 in neuroblastoma

Amber LouwagieBieke DecaestekerEva D'haeneLouis DelhayeEric de Bony de LavergneChristophe Van NesteRogier VersteegSara EkBjörn MentenJan Koster et al.

mTor inhibitor GDC-0349 improves ASO induced SAMMSON knock down resulting in enhanced anti-tumor efficacy in uveal melanoma

Shanna DewaeleBoel De PaepeLouis DelhayeEric de Bony de LavergneJilke De WildeKatrien VanderheydenJasper AnckaertNurten YigitEveline Vanden EyndeFariba Nemati et al.

mTor inhibitor GDC-0349 improves ASO induced SAMMSON knock down resulting in enhanced anti-tumor efficacy in uveal melanoma

Shanna DewaeleBoel De PaepeLouis DelhayeEric de Bony de LavergneJilke De WildeKatrien VanderheydenJasper AnckaertNurten YigitEveline Vanden EyndeFariba Nemati et al.

2019

A well-controlled BioID design for endogenous bait proteins

Giel VandemoorteleDelphine De SutterAline MoliereJarne PauwelsKris GevaertSven Eyckerman

A1 Journal Article in JOURNAL OF PROTEOME RESEARCH

Discovering cellular protein-protein interactions : technological strategies and opportunities

Kevin TitecaIrma LemmensJan TavernierSven Eyckerman

A1 Journal Article in MASS SPECTROMETRY REVIEWS

Orthogonal proteomic methods to decipher the RNA-protein interactome of the long non-coding RNA HOTAIR

Louis DelhayeEdith De BruyckerEric de Bony de LavergneDelphine De SutterPieter MestdaghSven Eyckerman

Phosphorylation of the multifunctional signal transducer B-cell adaptor protein (BCAP) promotes recruitment of multiple SH2/SH3 proteins including GRB2

Johannes U LauensteinAtul UdgataAlex BartramDelphine De SutterDavid I FisherSamer HalabiSven EyckermanNicholas J Gay

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Pick a tag and explore the functions of your pet protein

Giel VandemoorteleSven EyckermanKris Gevaert

A1 Journal Article in TRENDS IN BIOTECHNOLOGY

RNA-directed proteomics to explore the interactome of the melanoma-specific lncRNA SAMMSON

Louis DelhayeShanna DewaeleDelphine De SutterPieter MestdaghSven Eyckerman

The generation and use of recombinant extracellular vesicles as biological reference material

Edward GeeurickxJoeri TulkensBert DhondtJan Van DeunLien LippensGlenn VergauwenElisa HeyrmanDelphine De SutterKris GevaertFrancis Impens et al.

A1 Journal Article in NATURE COMMUNICATIONS

Therapeutic applications of SAMMSON lncRNA inhibition in uveal melanoma

Shanna DewaeleKatrien VanderheydenBoel De PaepeLouis DelhayeFariba NematiDidier DecaudinSven EyckermanRudy Van CosterJo VandesompelePieter Mestdagh

Therapeutic applications of SAMMSON lncRNA inhibition in uveal melanoma

Shanna DewaeleKatrien VanderheydenBoel De PaepeLouis DelhayeFariba NematiDidier DecaudinSven EyckermanRudy Van CosterJo VandesompelePieter Mestdagh

Therapeutic applications of SAMMSON lncRNA inhibition in uveal melanoma

Shanna DewaeleKatrien VanderheydenBoel De PaepeLouis DelhayeFariba NematiDidier DecaudinSven EyckermanRudy Van CosterJo VandesompelePieter Mestdagh

Towards a genome engineering toolbox for proteomics

Giel VandemoorteleSven EyckermanKris Gevaert

2018

A protein-protein interaction map of the TNF-induced NF-κB signal transduction pathway

Emmy Van QuickelbergheDelphine De SutterGeert van LooSven EyckermanKris Gevaert

A1 Journal Article in SCIENTIFIC DATA

High-confidence interactome for RNF41 built on multiple orthogonal assays

Delphine MasschaeleJoris WaumanGiel VandemoorteleDelphine De SutterLeentje De CeuninckSven EyckermanJan Tavernier

A1 Journal Article in JOURNAL OF PROTEOME RESEARCH

Mutations in LZTR1 drive human disease by dysregulating RAS ubiquitination

M SteklovS PandolfiMF BaiettiA BatiukP CaraiP NajmM ZhangH JangF RenziY Cai et al.

A1 Journal Article in SCIENCE

Recombinant extracellular vesicles : biological reference material to standardize extracellular vesicle research

Edward GeeurickxElisa HeyrmanJan Van DeunLien LippensJoeri TulkensBert DhondtGlenn VergauwenKris GevaertFrancis ImpensIlkka Miinalainen et al.

Recombinant extracellular vesicles : biological reference material to standardize extracellular vesicle research

Edward GeeurickxElisa HeyrmanJan Van DeunLien LippensJoeri TulkensBert DhondtGlenn VergauwenKris GevaertFrancis ImpensIlkka Miinalainen et al.

The neuroblastoma-specific lncRNA NESPR activates PHOX2B expression and is essential for neuroblastoma cell survival

Dries RombautTiago França BrazaoLouis DelhayeEva D'haeneGiorgio MilazzoRoberto CiaccioNurten YigitCeline EveraertMatthias FischerThorsten Simon et al.

The RRM2-PHF6 complex protects neuroblastoma cells from DNA damage accumulation to install a replication stress resistance phenotype

Carolina de Carvalho NunesKaat DurinckLisa DepestelSiebe LoontiensLouis DelhayeSofia ZanottiEmmy DolmanAline EggermontBieke DecaestekerPauline Depuydt et al.

2017

Analyzing trapped protein complexes by Virotrap and SFINX

Kevin TitecaEmmy Van QuickelbergheNoortje SamynDelphine De SutterAnnick VerheeKris GevaertJan TavernierSven Eyckerman

A1 Journal Article in NATURE PROTOCOLS

Involvement of the glucocorticoid receptor in pro-inflammatory transcription factor inhibition by daucane esters from Laserpitium zernyi

Visnja PopovicJan GoemanNadia BougarneSven EyckermanArne HeyerickKarolien De BosscherJohan Van der Eycken

A1 Journal Article in JOURNAL OF NATURAL PRODUCTS

Novel technologies for the analysis of protein complexes

Kevin TitecaJan TavernierSven Eyckerman

Protein complex analysis : from raw protein lists to protein interaction networks

Pieter MeysmanKevin TitecaSven EyckermanJan TavernierBart GoethalsLennart MartensDirk ValkenborgKris Laukens

A1 Journal Article in MASS SPECTROMETRY REVIEWS

Robust generation of knock-in cell lines using CRISPR-Cas9 and rAAV-assisted repair template delivery

Giel VandemoorteleDelphine De SutterSven Eyckerman

A2 Journal Article in BIO-PROTOCOL

sfinx : an R package for the elimination of false positives from affinity purification-mass spectrometry datasets

Kevin TitecaPieter MeysmanKris LaukensLennart MartensJan TavernierSven Eyckerman

A1 Journal Article in BIOINFORMATICS

2016

An extra dimension in protein tagging by quantifying universal proteotypic peptides using targeted proteomics

Giel VandemoorteleAn StaesGiulia GonnelliNoortje SamynDelphine De SutterElien VandermarliereEvy TimmermanKris GevaertLennart MartensSven Eyckerman

A1 Journal Article in SCIENTIFIC REPORTS

An omics strategy to unravel the role of the β2-adrenergic receptor in inflammation

Sarah GerloGuy LaureysKrzysztof KolmusSven EyckermanKris GevaertIrma LemmensJan Tavernier

HIV-1 Vpr N-terminal tagging affects alternative splicing of the viral genome

Ann BaeyensEvelien NaessensAnouk Van NuffelKarin WeeningAnne-Marie ReillyEva ClaeysWim TrypsteenLinos VandekerckhoveSven EyckermanKris Gevaert et al.

A1 Journal Article in SCIENTIFIC REPORTS

Intelligent mixing of proteomes for elimination of false positives in affinity purification-mass spectrometry

Sven EyckermanFrancis ImpensEmmy Van QuickelbergheNoortje SamynGiel VandemoorteleDelphine De SutterJan TavernierKris Gevaert

A1 Journal Article in JOURNAL OF PROTEOME RESEARCH

Melanoma addiction to the long non-coding RNA SAMMSON

Eleonora LeucciRoberto VendraminMarco SpinazziPatrick LauretteMark FiersJasper WoutersEnrico RadaelliSven EyckermanCarina LeonelliKatrien Vanderheyden et al.

A1 Journal Article in NATURE

Proteome-scale binary interactomics in human cells

Sam LievensJosé Van Der HeydenDelphine MasschaeleLeentje De CeuninckIoanna PettaSurya GuptaVeronic De PuysseleyrVirginie VauthierIrma LemmensDries De Clercq et al.

A1 Journal Article in MOLECULAR & CELLULAR PROTEOMICS

Proteomics in the genome engineering era

Giel VandemoorteleKris GevaertSven Eyckerman

A1 Journal Article in PROTEOMICS

SFINX : straightforward filtering index for affinity purification mass spectrometry data analysis

Kevin TitecaPieter MeysmanKris GevaertJan TavernierKris LaukensLennart MartensSven Eyckerman

A1 Journal Article in JOURNAL OF PROTEOME RESEARCH

Trapping mammalian protein complexes in viral particles

Sven EyckermanKevin TitecaEmmy Van QuickelbergheEva ClootsAnnick VerheeNoortje SamynLeentje De CeuninckEvy TimmermanDelphine De SutterSam Lievens et al.

A1 Journal Article in NATURE COMMUNICATIONS

2014

The small GTPase Arf6 is essential for the Tram/Trif pathway in RLR4 signaling

Tim Van AckerSven EyckermanLieselotte Vande WalleSarah GerloMarc GoethalsMohamed LamkanfiCelia BovijnJan TavernierFrank Peelman

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

2013

The Sin3a repressor complex regulates the balance between the activities of different STAT proteins

Laura IcardiRaffaele MoriViola GesellchenSven EyckermanJudith VerhelstKoen VercauterenXavier SaelensPhilip MeulemanKarolien De BosscherM Boutros et al.

2012

The Sin3a repressor complex is a master regulator of STAT transcriptional activity

Laura IcardiRaffaele MoriViola GesellchenSven EyckermanLode De CauwerJudith VerhelstKoen VercauterenXavier SaelensPhilip MeulemanGeert Leroux-Roels et al.

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

2011

STAT3 transcriptional activity is controlled by regulated acetylation

Jan TavernierLaura IcardiViola GesellchenRaffaele MoriSam LievensSven EyckermanJennyfer BultinckM BoutrosKarolien De Bosscher

Toward clinical proteomics on a next-generation sequencing platform

Daniel J TurnerRobin TuyttenKris PF JanssenJeroen LammertynJan WuytsJeroen PolletSven EyckermanClive BrownKoen Kas

A1 Journal Article in ANALYTICAL CHEMISTRY

2010

Bcl9/Bcl9l are critical for Wnt-mediated regulation of stem cell traits in colon epithelium and adenocarcinomas

Jürgen DekaNorbert WiedemannPascale AnderleFabienne Murphy-SeilerJennyfer BultinckSven EyckermanJean-Christophe StehleSylvie AndréNathalie VilainOlav Zilian et al.

A1 Journal Article in CANCER RESEARCH

Large-scale protein interactome mapping: strategies and opportunities

Sam LievensSven EyckermanIrma LemmensJan Tavernier

A1 Journal Article in EXPERT REVIEW OF PROTEOMICS

2009

BCL9 is an essential component of canonical Wnt signaling that mediates the differentiation of myogenic progenitors during muscle regeneration

Andrew S BrackFabienne Murphy-SeilerJasmine HanifiJürgen DekaCharles KellerSven EyckermanMichel AguetThomas A Rando

A1 Journal Article in DEVELOPMENTAL BIOLOGY

2007

Novel role of WD40 and SOCS box protein-2 in steady-state distribution of granulocyte colony-stimulating factor receptor and G-CSF-controlled proliferation and differentiation signaling

SJ ERKELANDLH AARTSM IRANDOUSTO ROOVERSA KLOMPM VALKHOFJ GITSSven EyckermanJan TavernierIP TOUW

A1 Journal Article in ONCOGENE

The C-terminus of CIS defines its interaction pattern

Delphine LavensPeter UlrichtsDominiek CatteeuwKris GevaertJoël VandekerckhoveFrank PeelmanSven EyckermanJan Tavernier

A1 Journal Article in BIOCHEMICAL JOURNAL

2006

A complex interaction pattern of CIS and SOCS2 with the leptin receptor

Delphine LavensTony MontoyeJulie PiessevauxLennart ZabeauJoël VandekerckhoveKris GevaertW BECKERSven EyckermanJan Tavernier

A1 Journal Article in JOURNAL OF CELL SCIENCE

Reverse MAPPIT detects disruptors of protein-protein interactions in human cells

Irma LemmensSam LievensSven EyckermanJan Tavernier

A1 Journal Article in NATURE PROTOCOLS

Two-hybrid and its recent adaptations

Sam LievensIrma LemmensTony MontoyeSven EyckermanJan Tavernier

A2 Journal Article in DRUG DISCOVERY TODAY. TECHNOLOGIES

2005

A systematic scan of interactions with tyrosine motifs in the erythropoietin receptor using a mammalian 2-hybrid approach

Tony MontoyeIrma LemmensDominiek CatteeuwSven EyckermanJan Tavernier

A1 Journal Article in BLOOD

Leptin, immune responses and autoimmune disease. Perspectives on the use of leptin antagonists

Frank PeelmanHannes IserentantSven EyckermanLennart ZabeauJan Tavernier

A1 Journal Article in CURRENT PHARMACEUTICAL DESIGN

Reverse MAPPIT: screening for protein-protein interaction modifiers in mammalian cells

Sven EyckermanIrma LemmensDominiek CatteeuwAnnick VerheeJoël VandekerckhoveSam LievensJan Tavernier

A1 Journal Article in NATURE METHODS

2004

Leptin: linking adipocyte metabolism with cardiovascular and autoimmune diseases

Frank PeelmanWim WaelputHannes IserentantDelphine LavensSven EyckermanLennart ZabeauJan Tavernier

A1 Journal Article in PROGRESS IN LIPID RESEARCH

2003

Heteromeric MAPPIT: a novel strategy to study modification-dependent protein-protein interactions in mammalian cells

Irma LemmensSven EyckermanLennart ZabeauDominiek CatteeuwEls VertentenK VERSCHUEREND HUYLEBROECKJoël VandekerckhoveJan Tavernier

A1 Journal Article in NUCLEIC ACIDS RESEARCH

The ins and outs of leptin receptor activation

Lennart ZabeauDelphine LavensFrank PeelmanSven EyckermanJoël VandekerckhoveJan Tavernier

A1 Journal Article in FEBS LETTERS

2002

Comparison of leptin- and interleukin-6-regulated expression of the rPAP gene family: evidence for differential co-regulatory signals

Daniël BroekaertSven EyckermanDelphine LavensAnnick VerheeWim WaelputJoël VandekerckhoveJan Tavernier

A1 Journal Article in EUROPEAN CYTOKINE NETWORK

Design and use of a mammalian protein-protein interaction trap (MAPPIT)

Sven EyckermanIrma LemmensSam LievensJ VAN DER HEYDENA VERHEEJoël VandekerckhoveJan Tavernier

A2 Journal Article in Science's signal transduction knowledge environment

MAPPIT: a cytokine receptor-based two-hybrid method in mammalian cells.

Jan TavernierSven EyckermanIrma LemmensJ VAN DER HEYDENJoël VandekerckhoveXaveer Van Ostade

A1 Journal Article in CLINICAL AND EXPERIMENTAL ALLERGY

Methods to map protein interactions in mammalian cells: different tools to address different questions.

Sven EyckermanJan Tavernier

A1 Journal Article in EUROPEAN CYTOKINE NETWORK

2001

Design and application of a cytokine-receptor-based interaction trap.

Sven EyckermanA VERHEEJ VAN DER HEYDENIrma LemmensXaveer Van OstadeJoël VandekerckhoveJan Tavernier

A1 Journal Article in NATURE CELL BIOLOGY

2000

Identification and expression analysis of leptin-regulated immediate early response and late target genes

Wim WaelputAnnick VerheeDaniël BroekaertSven EyckermanJoël VandekerckhoveJH BeattieJan Tavernier

A1 Journal Article in BIOCHEMICAL JOURNAL

Identification of the Y985 and Y1077 motifs as SOCS3 recruitment sites in the murine leptin receptor.

Sven EyckermanDaniël BroekaertA VERHEEJoël VandekerckhoveJan Tavernier

A1 Journal Article in FEBS LETTERS

1999

Analysis of Tyr to Phe and the fa/fa leptin receptor mutations in the PC12 cell line

Sven EyckermanWim WaelputAnnick VerheeDaniël BroekaertJoël VandekerckhoveJan Tavernier

A1 Journal Article in EUROPEAN CYTOKINE NETWORK