Research Explorer

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Researcher

Susana Marina Chuva de Sousa Lopes

Publications & Research Data

Awards & Distinctions

70 Results

2025

Biphasic CAPA-IVM improves equine oocyte quality and subsequent embryo development without inducing genetic aberrations

Muhammad Fakhar I AdilDaniel Angel VelezEmin AraftpoorQurratul Ain AminMohamed HediaMarcel BühlerKris GevaertBjörn MentenAnn Van SoomSusana Marina Chuva de Sousa Lopes et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

2024

Biphasic CAPA-IVM in Ovarian Tissue Oocyte Maturation: Insights from Transgender Men Undergoing Gender Reassignment

Muhammad Fakhar I AdilAntonia ChristodoulakiSusana Marina Chuva de Sousa LopesSteven WeyersBjörn MentenAnn Van SoomDominic StoopChloë De RooBjörn Heindryckx

Effect of biphasic CAPA-IVM on ovarian tissue oocytes of transgender men

Muhammad Fakhar-I-AdilAntonia ChristodoulakiSusana Marina Chuva de Sousa LopesSteven WeyersBjörn MentenAnn Van SoomDominic StoopChloë De RooBjörn Heindryckx

2023

Characterization of ovarian tissue oocytes from transgender men reveals poor calcium release and embryo development, which might be overcome by spindle transfer

Antonia ChristodoulakiHaitang HeMin ZhouArantxa Cardona BarberánChloë De RooSusana Marina Chuva de Sousa LopesMachteld BaetensBjörn MentenAnn Van SoomPetra De Sutter et al.

A1 Journal Article in HUMAN REPRODUCTION

Effect of biphasic CAPA-IVM on ovarian tissue oocytes of transgender men

Muhammad Fakhar-I-AdilAntonia ChristodoulakiAnnekatrien BoelSusana Marina Chuva de Sousa LopesBjörn MentenAnn Van SoomDominic StoopChloë De RooBjörn Heindryckx

Retained chromosomal integrity following CRISPR-Cas9-based mutational correction in human embryos

Bieke BekaertAnnekatrien BoelLisa De WitteWinter VandenbergheMina PopovicPanagiotis StamatiadisGwenny CosemansLise TordeursAthina-Maria De LooreSusana Marina Chuva de Sousa Lopes et al.

A1 Journal Article in MOLECULAR THERAPY

2022

Characterization of the epidermal-dermal junction in hiPSC-derived skin organoids

Veronika RamovsHans JanssenIgnacia FuentesAmandine PitavalWalid RachidiSusana Marina Chuva de Sousa LopesChristian FreundXavier GidrolChristine L. MummeryKarine Raymond

A1 Journal Article in STEM CELL REPORTS

Distinct genetic impact of CRISPR/Cas9 gene correction in human embryos compared to induced pluripotent stem cells

Bieke BekaertAnnekatrien BoelLisa De WitteGwenny CosemansLise TordeursAthina-Maria De LooreSusana Marina Chuva de Sousa LopesPetra De SutterDominic StoopPaul Coucke et al.

Dynamic in vitro culture of cryopreserved-thawed human ovarian cortical tissue using a microfluidics platform does not improve early folliculogenesis

Julieta S. Del ValleVanessa ManciniMaitane Laverde GarayJoyce D. AsselerXueying FanJeroen MetzemaekersLeoni A. LouweGonneke S. K. PilgramLucette A. J. van der WesterlakenNorah M. van Mello et al.

A1 Journal Article in FRONTIERS IN ENDOCRINOLOGY

Emerging in vitro platforms and omics technologies for studying the endometrium and early embryo-maternal interface in humans

Mina PopovicSusana Marina Chuva de Sousa Lopes

A1 Journal Article in PLACENTA

Evaluation of CRISPR/Cas9-induced DNA break repair outcomes in mouse and human embryos

Bieke BekaertAnnekatrien BoelLisa De WitteGwenny CosemansSusana Marina Chuva de Sousa LopesBjörn MentenBjörn Heindryckx

Fetal germ cell development in humans, a link with infertility

Sylwia M. CzukiewskaSusana Marina Chuva de Sousa Lopes

A1 Journal Article in SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

TEAD4 regulates trophectoderm differentiation upstream of CDX2 in a GATA3-independent manner in the human preimplantation embryo

Panagiotis StamatiadisGwenny CosemansAnnekatrien BoelBjörn MentenPetra De SutterDominic StoopSusana Marina Chuva de Sousa LopesFrederic LluisPaul CouckeBjörn Heindryckx

A1 Journal Article in HUMAN REPRODUCTION

The development of the amnion in mice and other amniotes

Susana Marina Chuva de Sousa LopesBernard A. J. RoelenKirstie A. A. LawsonAn Zwijsen

A1 Journal Article in PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

The extended analogy of extraembryonic development in insects and amniotes

Kristen A. A. PanfilioSusana Marina Chuva de Sousa Lopes

A1 Journal Article in PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

2021

Activin A-derived human embryonic stem cells show increased competence to differentiate into primordial germ cell-like cells

Swati MishraJasin TaelmanMina PopovicLaurentijn TillemanEvi DuthooMargot Van der JeughtDieter DeforceFilip Van NieuwerburghBjörn MentenPetra De Sutter et al.

A1 Journal Article in STEM CELLS

Calcium analysis and embryonic development of in vitro matured oocytes from transgender men

Antonia ChristodoulakiHaitang HeArantxa Cardona BarberánChloë De RooSusana Marina Chuva de Sousa LopesBjörn MentenAnn Van SoomPetra De SutterDominic StoopAnnekatrien Boel et al.

Comparative analysis of mouse and human preimplantation development following POU5F1 CRISPR/Cas9 targeting reveals interspecies differences

Panagiotis StamatiadisAnnekatrien BoelGwenny CosemansMina PopovicBieke BekaertRamesh Reddy GuggillaMaoxing TangPetra De SutterFilip Van NieuwerburghBjörn Menten et al.

A1 Journal Article in HUMAN REPRODUCTION

Engineered models of the human embryo

Mina PopovicFelicitas AzpirozSusana Marina Chuva de Sousa Lopes

Editorial material

Improving in vitro culture of human male fetal germ cells

Myriam Martin-InarajaMonica FerreiraJasin TaelmanCristina EguizabalSusana Marina Chuva de Sousa Lopes

A1 Journal Article in CELLS

Ligand-receptor interactions elucidate sex-specific pathways in the trajectory from primordial germ cells to gonia during human development

Arend W. OvereemYolanda W. ChangJeroen SpruitCeline M. RoelseSusana Marina Chuva de Sousa Lopes

A1 Journal Article in FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY

Sex-specific isolation and propagation of human premeiotic fetal germ cells and germ cell-like cells

Swati MishraJasin TaelmanYolanda W. ChangAnnekatrien BoelPetra De SutterBjörn HeindryckxSusana Marina Chuva de Sousa Lopes

A1 Journal Article in CELLS

Single-cell transcriptomics analysis of human small antral follicles

Xueying FanIoannis MoustakasMonika BialeckaJulieta S. del ValleArend W. OvereemLeoni A. LouweGonneke S. K. PilgramLucette A. J. van der WesterlakenHailiang MeiSusana Marina Chuva de Sousa Lopes

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Strand-specific single-cell methylomics reveals distinct modes of DNA demethylation dynamics during early mammalian development

Maya SenDylan MooijmanAlex ChialastriJean-Charles BoissetMina PopovicBjörn HeindryckxSusana Marina Chuva de Sousa LopesSiddharth S. DeyAlexander van Oudenaarden

A1 Journal Article in NATURE COMMUNICATIONS

Tissue of origin, but not XCI state, influences germ cell differentiation from human pluripotent stem cells

Yolanda W. ChangArend W. OvereemCeline M. RoelseXueying FanChristian FreundSusana Marina Chuva de Sousa Lopes

A1 Journal Article in CELLS

Transcriptional progression during meiotic prophase I reveals sex-specific features and X chromosome dynamics in human fetal female germline

Xueying FanIoannis MoustakasVanessa Torrens-JuanedaQijing LeiGeert HamerLeoni A. LouweGonneke S. K. PilgramKaroly SzuhaiRoberto MatorrasCristina Eguizabal et al.

A1 Journal Article in PLOS GENETICS

2020

A proof-of-concept study to investigate DNA repair mechanisms in the human embryo after the application of CRISPR/Cas9 gene editing in the germ line

Bieke BekaertAnnekatrien BoelLisa De WitteMina PopovicRamesh Reddy GuggillaSwati MishraGwenny CosemansLise TordeursSusana Marina Chuva de Sousa LopesPetra De Sutter et al.

Correcting a PLCζ mutation in the human germ line to overcome hereditary infertility

Bieke BekaertAnnekatrien BoelMina PopovicPanagiotis StamatiadisSusana Marina Chuva de Sousa LopesPetra De SutterPaul CouckeBjörn Heindryckx

Correcting PLCζ mutation in the germ line to overcome transmission of hereditary infertility in mice

Bieke BekaertAnnekatrien BoelVanessa ThysPanagiotis StamatiadisSusana Marina Chuva de Sousa LopesPetra De SutterJohn ParringtonBjörn MentenDominic StoopPaul Coucke et al.

Human fetal microglia acquire homeostatic immune-sensing properties early in development

L. KrachtM. BorggreweS. EskandarN. BrouwerSusana Marina Chuva de Sousa LopesJ. D. LamanS. A. ScherjonJ. R. PrinsS. M. KooistraB. J. L. Eggen

A1 Journal Article in SCIENCE

Modelling human embryogenesis : embryo-like structures spark ethical and policy debate

AM Pereira DaoudMina PopovicWJ DondorpM Trani BustosAL BredenoordSusana Marina Chuva de Sousa LopesSC van den BrinkRoelen BAJde Wert GMWRBjörn Heindryckx

A1 Journal Article in HUMAN REPRODUCTION UPDATE

The TGF beta family in human placental development at the fetal-maternal interface

Susana Marina Chuva de Sousa LopesMarta S. AlexdottirGudrun Valdimarsdottir

A1 Journal Article in BIOMOLECULES

2019

Human blastocyst outgrowths recapitulate primordial germ cell specification events

Mina PopovicMonika BialeckaMaria Gomes FernandesJasin TaelmanMargot Van der JeughtPetra De SutterBjörn HeindryckxSusana Marina Chuva de Sousa Lopes

A1 Journal Article in MOLECULAR HUMAN REPRODUCTION

Single-cell reconstruction of follicular remodeling in the human adult ovary

X. FanM. BialeckaI MoustakasE. LamV Torrens-JuanedaV Borggreven, N.L. TrouwL. A. LouweG. S. K. PilgramH. Mei et al.

A1 Journal Article in NATURE COMMUNICATIONS

Single-cell transcriptomics reveals gene expression dynamics of human fetal kidney development

Mazene HochanePatrick R. van den BergXueying FanNoemie Berenger-CurriesEsmee AdegeestMonika BialeckaMaaike NieveenMaarten MenschaartSusana Marina Chuva de Sousa LopesStefan Semrau

A1 Journal Article in PLOS BIOLOGY

Two decades of embryonic stem cells : a historical overview

Cristina EguizabalBegoña AranSusana Marina Chuva de Sousa LopesM. GeensBjörn HeindryckxS. PanulaMina PopovicRita VassenaAnna Veiga

A1 Journal Article in HUMAN REPRODUCTION OPEN

WNT inhibition and increased fibroblast growth factor signaling promotes derivation of less heterogeneous primed human embryonic stem cells, compatible with differentiation

Jasin TaelmanMina PopovicMonika BialeckaLaurentijn TillemanSharat WarrierMargot Van der JeughtBjörn MentenDieter DeforcePetra De SutterFilip Van Nieuwerburgh et al.

A1 Journal Article in STEM CELLS AND DEVELOPMENT

2018

3D modeling of esophageal development using human PSC-derived basal progenitors reveals a critical role for notch signaling

Yongchun ZhangYing YangMing JiangSarah Xuelian HuangWanwei ZhangDenise Al AlamSoula DanopoulosMunemasa MoriYa-Wen ChenRevathi Balasubramanian et al.

A1 Journal Article in CELL STEM CELL

Characterization of migratory primordial germ cells in the aortagonad-mesonephros of a 4.5-week-old human embryo : a toolbox to evaluate in vitro early gametogenesis

Maria Gomes FernandesMonika BialeckaDaniela CF SalvatoriSusana Marina Chuva de Sousa Lopes

A1 Journal Article in MOLECULAR HUMAN REPRODUCTION

Human-specific subcellular compartmentalization of P-element induced wimpy testis-like (PIWIL) granules during germ cell development and spermatogenesis

Maria Gomes FernandesNannan HeFang WangLiesbeth Van IperenCristina EguizabalRoberto MatorrasBernard AJ RoelenSusana Marina Chuva de Sousa Lopes

A1 Journal Article in HUMAN REPRODUCTION

Impact of pluripotency state and Activin A supplementation on derivation of primordial germ cell-like cells from human

Swati MishraMargot Van der JeughtJasin TaelmanMina PopovicKatarzyna Szymańska-VandendriesscheDieter DeforcePetra De SutterSusana Marina Chuva de Sousa LopesBjörn Heindryckx

Parental haplotype-specific single-cell transcriptomics reveal incomplete epigenetic reprogramming in human female germ cells

Abel VertesyWibowo ArindrartoMatthias S RoostBjorn ReiniusVanessa Torrens-JuanedaMonika BialeckaIoannis MoustakasYavuz AriyurekEwart KuijkHailiang Mei et al.

A1 Journal Article in NATURE COMMUNICATIONS

Transcriptional landscape changes during human embryonic stem cell derivation

Sharat WarrierJasin TaelmanLaurentijn TillemanMargot Van der JeughtGalbha DuggalSylvie LiermanMina PopovicAnn Van SoomLuc PeelmanFilip Van Nieuwerburgh et al.

A1 Journal Article in MOLECULAR HUMAN REPRODUCTION

2017

Direct comparison of distinct naive pluripotent states in human embryonic stem cells

Sharat WarrierMargot Van der JeughtGalbha DuggalLaurentijn TillemanElla SutherlandJasin TaelmanMina PopovicSylvie LiermanSusana Marina Chuva de Sousa LopesAnn Van Soom et al.

A1 Journal Article in NATURE COMMUNICATIONS

Wnt inhibition during hESC culture provides an improved pluripotent state starting point for directed differentiation

Jasin TaelmanLaurentijn TillemanFilip Van NieuwerburghSharat WarrierMina PopovicMargot Van der JeughtDieter DeforcePetra De SutterBjörn HeindryckxSusana Marina Chuva de Sousa Lopes

2016

BMP and Hedgehog regulate distinct AGM hematopoietic stem cells ex vivo

Mihaela CrisanParham Solaimani KartalaeiAlex NeaguSofia KarkanpounaTomoko Yamada-InagawaCaterina PuriniChris S VinkReinier van der LindenWilfred van IjckenSusana Marina Chuva de Sousa Lopes et al.

A1 Journal Article in STEM CELL REPORTS

BMP-SMAD signaling : from pluripotent stem cells to cardiovascular commitment

Valeria V OrlovaSusana Marina Chuva de Sousa LopesGudrun Valdimarsdottir

A1 Journal Article in CYTOKINE & GROWTH FACTOR REVIEWS

BMP-SMAD signaling regulates lineage priming, but is dispensable for self-renewal in mouse embryonic stem cells

Maria Gomes FernandesRuben DriesMatthias S RoostStefan SemrauAna de Melo BernardoRichard P DavisRamprasad RamakrishnanKaroly SzuhaiElke MaasLieve Umans et al.

A1 Journal Article in STEM CELL REPORTS

Germline development in amniotes : a paradigm shift in primordial germ cell specification

Federica BertocchiniSusana Marina Chuva de Sousa Lopes

A1 Journal Article in BIOESSAYS

On the development of extragonadal and gonadal human germ cells

A Marijne HeerenNannan HeAline F de SouzaAngelique Goercharn-RamlalLiesbeth van IperenMatthias S RoostMaria M Gomes FernandesLucette AJ van der WesterlakenSusana Marina Chuva de Sousa Lopes

A1 Journal Article in BIOLOGY OPEN

The composition and differentiation potential of the duodenal intraepithelial innate lymphocyte compartment is altered in coeliac disease

Frederike SchmitzYvonne Kooy-WinkelaarAnna-Sophia WiekmeijerMartijn H BrugmanM Luisa MearinChris MulderSusana Marina Chuva de Sousa LopesChristine L MummeryFrank JT StaalJeroen van Bergen et al.

A1 Journal Article in GUT

Trisomy 21 alters DNA methylation in parent-of-origin-dependent and independent manners

Antônio Francisco Alves da SilvaFilipe Brum MachadoÉrika Cristina PavarinoJoice Matos Biselli-PéricoBruna Lancia ZampieriRonaldo da Silva Francisco JuniorPedro Thyago Mozer RodriguesDouglas Terra MachadoCíntia Barros Santos-RebouçasMaria Gomes Fernandes et al.

A1 Journal Article in PLOS ONE

Uncovering the novel role of mTORC2 subunit of the PI3K/AKT/mTORC pathway in establishing naive pluripotency in human embryonic stem cells

Sharat WarrierMargot Van der JeughtGalbha DuggalJasin TaelmanSylvie LiermanSusana Marina Chuva de Sousa LopesAnn Van SoomLuc PeelmanFilip Van NieuwerburghDieter De Coninck et al.

2015

Alternative routes to induce naive pluripotency in human embryonic stem cells

Galbha DuggalSharat WarrierSabitri GhimireDorien BroekaertMargot Van der JeughtSylvie LiermanTom DerooLuc PeelmanAnn Van SoomMaria Cornelissen et al.

A1 Journal Article in STEM CELLS

Application of small molecules favoring naive pluripotency during human embryonic stem cell derivation

Margot Van der JeughtJasin TaelmanGalbha DuggalSabitri GhimireSylvie LiermanSusana Marina Chuva de Sousa LopesDieter DeforceTom DerooPetra De SutterBjörn Heindryckx

A1 Journal Article in CELLULAR REPROGRAMMING

Atrial-like cardiomyocytes from human pluripotent stem cells are a robust preclinical model for assessing atrial-selective pharmacology

Harsha D DevallaVerena SchwachJohn W FordJames T MilnesSaid El-HaouClaire JacksonKonstantinos GkatzisDavid A ElliottSusana Marina Chuva de Sousa LopesChristine L Mummery et al.

A1 Journal Article in EMBO MOLECULAR MEDICINE

Current status of in vitro differentiation of stem cells into gametes

Susana Marina Chuva de Sousa LopesBAJ Roelen

A1 Journal Article in ANIMAL REPRODUCTION

Derivation conditions affect pluripotency and differentiation propensity of mouse embryonic stem cells

Sabitri GhimireMargot Van der JeughtJitesh NeupaneFilip Van NieuwerburghDieter DeforceSusana Marina Chuva de Sousa LopesPetra De SutterBjörn Heindryckx

Development of the follicular basement membrane during human gametogenesis and early folliculogenesis

A Marijne HeerenLiesbeth van IperenDaniëlle B KlootwijkAna de Melo BernardoMatthias S RoostMaria M Gomes FernandesLeonie A LouweCarina G HildersFrans M HelmerhorstLucette AJ van der Westerlaken et al.

A1 Journal Article in BMC DEVELOPMENTAL BIOLOGY

Development of the stria vascularis and potassium regulation in the human fetal cochlea : insights into hereditary sensorineural hearing loss

Heiko LocherJohn CMJ de GrootLiesbeth van IperenMargriet A HuismanJohan HM FrijnsSusana Marina Chuva de Sousa Lopes

A1 Journal Article in DEVELOPMENTAL NEUROBIOLOGY

DNA methylation landscapes of human fetal development

Roderick C SliekerMatthias S RoostLiesbeth van IperenH Eka D SuchimanElmar W TobiFrançoise CarlottiEelco JP de KoningP Eline SlagboomBastiaan T HeijmansSusana Marina Chuva de Sousa Lopes

A1 Journal Article in PLOS GENETICS

Exogenous supplementation of Activin A enhances germ cell differentiation of human embryonic stem cells

Galbha DuggalBjörn HeindryckxSharat WarrierJasin TaelmanMargot Van der JeughtDieter DeforceSusana Marina Chuva de Sousa LopesPetra De Sutter

A1 Journal Article in MOLECULAR HUMAN REPRODUCTION

Inhibition of transforming growth factor β signaling promotes epiblast formation in mouse embryos

Sabitri GhimireBjörn HeindryckxMargot Van der JeughtJitesh NeupaneThomas O'LearySylvie LiermanWinnok De VosSusana Marina Chuva de Sousa LopesTom DerooPetra De Sutter

A1 Journal Article in STEM CELLS AND DEVELOPMENT

KeyGenes, a tool to probe tissue differentiation using a human fetal transcriptional atlas

Matthias S RoostLiesbeth van IperenYavuz AriyurekHenk P BuermansWibowo ArindrartoHarsha DevallaRobert PassierChristine L MummeryFrançoise CarlottiEelco JP de Koning et al.

A1 Journal Article in STEM CELL REPORTS

Meiotic wave adds extra asymmetry to the development of female chicken gonads

Ana De Melo BernardoA Marijne HeerenLiesbeth van IperenMaria Gomes FernandesNannan HeStafford AnjieToshiaki NoceEster Silveira RamosSusana Marina Chuva de Sousa Lopes

A1 Journal Article in MOLECULAR REPRODUCTION AND DEVELOPMENT

The post-inner cell mass intermediate : implications for stem cell biology and assisted reproductive technology

Margot Van der JeughtThomas O'LearyGalbha DuggalPetra De SutterSusana Marina Chuva de Sousa LopesBjörn Heindryckx

A1 Journal Article in HUMAN REPRODUCTION UPDATE

2014

Distribution and development of peripheral glial cells in the human fetal cochlea

Heiko LocherJohn CMJ de GrootLiesbeth van IperenMargriet A HuismanJohan HM FrijnsSusana Marina Chuva de Sousa Lopes

A1 Journal Article in PLOS ONE

Lymphangiogenesis and angiogenesis during human fetal pancreas development

Matthias S RoostLiesbeth van IperenAna de Melo BernardoChristine L MummeryFrançoise CarlottiEelco JP de KoningSusana Marina Chuva de Sousa Lopes

A2 Journal Article in VASCULAR CELL

Treatment of human embryos with the TGFβ inhibitor SB431542 increases epiblast proliferation and permits successful human embryonic stem cell derivation

Margot Van der JeughtBjörn HeindryckxThomas O'LearyGalbha DuggalSabitri GhimireSylvie LiermanNadine Van RoySusana Marina Chuva de Sousa LopesTom DerooDieter Deforce et al.

A1 Journal Article in HUMAN REPRODUCTION

2013

Influence of activin A supplementation during human embryonic stem cell derivation on germ cell differentiation potential

Galbha DuggalBjörn HeindryckxSharat WarrierThomas O'LearyMargot Van der JeughtSylvie LiermanLiesbeth VossaertTom DerooDieter DeforceSusana Marina Chuva de Sousa Lopes et al.

A1 Journal Article in STEM CELLS AND DEVELOPMENT