Research Explorer

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Researcher

Stijn Vanhee

Publications & Research Data

Awards & Distinctions

46 Results

2026

Chitin is a potent inducer of type 2 airway inflammation independent of endogenous chitinolytic activity

Jozefien DeclercqHelena Catharine AegerterUrsula SmoleKarel Van DammeEllen KetelaereInés LammensCaroline De WolfKarl VergoteManon VanheerswynghelsSofie De Prijck et al.

A1 Journal Article in ALLERGY

Cross-species cellular mapping and humanization of Fcγ receptors to advance antibody modeling

Karel Van DammeDorine SichienKatrien Van Der BorghtJustine Van MoorleghemSofie Van GassenJoseph JorssenSeppe De WinterElisabeth De LeeuwCaihong WangQingqing Chai et al.

A1 Journal Article in SCIENCE IMMUNOLOGY

HIF-1 α+ CD4+ T cells coordinate a tissue-resident immune cell network in the lung

Jean de LimaNivedya SwarnalekhaClaire E. DepewEwelina BartoszekLudivine C. LitzlerMara EspositoMaike ErberTiphaine M. N. CamarasaLorenzo IseppiMarco Künzli et al.

A1 Journal Article in IMMUNITY

Mechanisms and kinetics of wound healing in chronic rhinosinusitis patients after complete sinus surgery and its improvement by doxycycline therapy

Elke VandewalleEls De SchryverLien CalusManon BlauwblommePauline JanssenEllen KetelaereSharon Van NevelAnne-Sophie EeckelsNatalie De RuyckGabriële Holtappels et al.

A1 Journal Article in INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY

2025

A fentanyl hapten-displaying lipid nanoparticle vaccine that non-covalently encapsulates a TLR7/8 agonist and T-helper epitope induces protective anti-fentanyl immunity

Zifu ZhongMarie DeventerYong ChenStijn VanheeInés LammensKim DeswarteYi HuangTingting YeHaixiu WangLutz Nuhn et al.

A1 Journal Article in ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Distinct effects of biological treatments on eosinophils and neutrophils in chronic rhinosinusitis with nasal polyp patients

Sharon Van NevelNan ZhangZhaofeng XuManon BlauwblommeElke VandewalleGabriële HoltappelsNatalie De RuyckFilip Van NieuwerburghStijn VanheePhilippe Gevaert et al.

A1 Journal Article in CLINICAL AND TRANSLATIONAL ALLERGY

Lipid nanoparticles as a tool to dissect dendritic cell maturation pathways

Sofie RennenVictor BosteelsClint De NolfSandra MaréchalJessica VettersKaro Van LilGreta WebbJanne SwinnenEvelien Van De VeldeFarzaneh Fayazpour et al.

A1 Journal Article in CELL REPORTS

Maternal allergy and neonatal RSV infection synergize via FcR-mediated allergen uptake to promote the development of asthma in early life

Elisabeth De LeeuwJosefine F. JustesenCedric BosteelsNincy DebeufManon VanheerswynghelsLeander JonckheereCaroline De WolfAlysia WayenbergKarel Van DammeStijn Vanhee et al.

A1 Journal Article in SCIENCE IMMUNOLOGY

Nasal mucosal brushings could be used to define the endotype in nasal inflammatory diseases

Elke VandewalleGabriële HoltappelsNatalie De RuyckLara DeryckeManon BlauwblommeEllen KetelaereAnne-Sophie EeckelsThibaut Van ZeleStijn VanheePhilippe Gevaert

Real-life effectiveness of mepolizumab and omalizumab in sever uncontrolled chronic rhinosinusitis with nasal polyps : a prospective study

Manon BlauwblommePhilippe GevaertGuy BrusselleGeert De VosAnne-Sophie EeckelsStijn VanheeElke VandewalleGabriële HoltappelsNatalie De RuyckEllen Ketelaere et al.

Respiratory immunity at the intersection of infection, vaccination and allergy : mechanisms and modulation of type 1 and type 2 inflammation in the upper and lower airways

Jozefien DeclercqBart LambrechtPhilippe GevaertStijn Vanhee

Within-host mathematical models to study antibody kinetics after the prophylactic Ebola vaccine in the Democratic Republic of the Congo

Irene Garcia-FogedaSteven AbramsStijn VanheeMaha SalloumBenson OgunjimiNiel Hens

A1 Journal Article in VACCINE

2024

Case report : dual monoclonal antibody therapy in chronic rhinosinusitis with nasal polyps and severe eosinophilic asthma : a proteome analysis

Manon BlauwblommePhilippe GevaertSharon Van NevelSebastian RiemannElke VandewalleGabriële HoltappelsNatalie De RuyckLara DeryckeAnne-Sophie EeckelsStijn Vanhee et al.

A2 Journal Article in FRONTIERS IN ALLERGY

Lack of functional TCR-epitope interaction is associated with herpes zoster through reduced downstream T cell activation

Marlies BoerenNicky de VrijMy K. HaSebastiaan ValkiersAisha SouquetteSofie GielisMaria KuznetsovaJolien SchippersEsther BartholomeusJohan Van den Bergh et al.

A1 Journal Article in CELL REPORTS

Repeated COVID-19 mRNA-based vaccination contributes to SARS-CoV-2 neutralizing antibody responses in the mucosa

Jozefien DeclercqSarah GerloSharon Van NevelNatalie De RuyckGabriële HoltappelsLiesbeth DelesieEls TobbackInés LammensNikita GerebtsovKoen Sedeyn et al.

A1 Journal Article in SCIENCE TRANSLATIONAL MEDICINE

Shared lung and joint T cell repertoire in early rheumatoid arthritis driven by cigarette smoking

Koen VenkenMatthias JarlborgFrederik StevenaertThomas MalfaitCarolien VliegheYann AbrahamTeddy ManuelloTine DecruyStijn VanheeHans Wils et al.

A1 Journal Article in ANNALS OF THE RHEUMATIC DISEASES

TCR transgenic clone selection guided by immune receptor analysis and single-cell RNA expression of polyclonal responders

Nincy DebeufSahine LameireManon VanheerswynghelsJulie DeckersCaroline De WolfWendy ToussaintRein VerbekeKevin VerstaenHamida HammadStijn Vanhee et al.

A2 Journal Article in ELIFE

Unraveling inflammation in chronic rhinosinusitis : from endotyping to impact of biologicals

Sharon Van NevelClaus BachertPhilippe GevaertStijn Vanhee

2023

Effects of biologics treatment in type 2-high chronic rhinosinusitis with nasal polyp patients

Sharon Van NevelTim MeeseGabriële HoltappelsNatalie De RuyckStijn VanheeNan ZhangFilip Van NieuwerburghClaus Bachert

Enhanced protein synthesis is a defining requirement for neonatal B cell development

Hugo ÅkerstrandElena BoldrinGiorgia MontanoStijn VanheeKarin OlssonNiklas KrausseStefano VerganiMaciej CieślaCristian BellodiJoan Yuan

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

RNA viruses alter house dust mite physiology and allergen production with no detected consequences for allergenicity

José Cristian Vidal‐QuistJozefien DeclercqStijn VanheeBart LambrechtJosé Gómez‐RialCarmen VidalEylem Aydogdu LohausStephane RombautsPedro Hernández‐Crespo

A1 Journal Article in INSECT MOLECULAR BIOLOGY

The multi-omics single-cell landscape of sinus mucosa in uncontrolled severe chronic rhinosinusitis with nasal polyps

Zhaofeng XuYanran HuangTim MeeseSharon Van NevelGabriële HoltappelsStijn VanheeBarbara M. BrökerZhengqi LiEllen De MeesterNatalie De Ruyck et al.

A1 Journal Article in CLINICAL IMMUNOLOGY

2022

A self-sustaining layer of early-life-origin B cells drives steady-state IgA responses in the adult gut

Stefano VerganiKonjit Getachew MuletaClément Da SilvaAlexander DoyleTrine Ahn KristiansenSelene SodiniNiklas KrausseGiorgia MontanoKnut KotarskyJoy Nakawesi et al.

A1 Journal Article in IMMUNITY

COVID‐19 vaccination with BNT162b2 and ChAdOx1 vaccines has the potential to induce nasal neutralizing antibodies

Jozefien DeclercqEls TobbackStijn VanheeNatalie De RuyckSarah GerloPhilippe GevaertLinos Vandekerckhove

A1 Journal Article in ALLERGY

TIM3+ TRBV11-2 T cells and IFNγ signature in patrolling monocytes and CD16+ NK cells delineate MIS-C

Levi HosteLisa RoelsLeslie NaesensVictor BosteelsStijn VanheeSam DupontCedric BosteelsRobin BrowaeysNiels VandammeKevin Verstaen et al.

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

2021

Cyclin D2 overexpression drives B1a-derived MCL-like lymphoma in mice

Tim PietersSara T'SasStijn VanheeAndré Pedro Pinto De AlmeidaYasmine DriegeJuliette RoelsWouter Van LoockeWillem DaneelsMathijs BaensArnaud Marchand et al.

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

DALI (Diversity AnaLysis Interface) : a novel tool for the integrated analysis of multimodal single cell RNAseq data and immune receptor profiling

Kevin VerstaenInés LammensJana RoelsYvan SaeysBart LambrechtNiels VandammeStijn Vanhee

2019

Lin28b controls a neonatal to adult switch in B cell positive selection

Stijn VanheeHugo ÅkerstrandTrine Ahn KristiansenSebak DattaGiorgia MontanoStefano VerganiStefan LangJonas UngerbäckAlexander DoyleKarin Olsson et al.

A1 Journal Article in Science Immunology

2017

PTIP chromatin regulator controls development and activation of B cell subsets to license humoral immunity in mice

Dan SuStijn VanheeRebeca SoriaElin Jaensson GyllenbäckLinda M. StarnesMartina Kubec HøjfeldtGabriel K. PedersenJoan YuanJeremy A. Daniel

A1 Journal Article in Proceedings of the National Academy of Sciences

The influence of developmental timing on B cell diversity

Trine A KristiansenStijn VanheeJoan Yuan

A1 Journal Article in Current Opinion in Immunology

2016

Fetal to Adult Hematopoiesis with the “Flk” of a Switch

Stijn VanheeJoan Yuan

Editorial material

Humanized mice to study human T cell development

Sarah BonteSYLVIA SNAUWAERTStijn VanheeAnne-Catherine DolensTom TaghonBart VandekerckhoveTessa Kerre

Bookchapter in T-Cell development : methods and protocols

2015

In vitro human embryonic stem cell hematopoiesis mimics MYB-independent yolk sac hematopoiesis

Stijn VanheeKatrien De MulderYasmine Van CaeneghemGreet VerstichelNadine Van RoyBjörn MentenImke VelgheJan PhilippéDominique De BleserBart Lambrecht et al.

A1 Journal Article in HAEMATOLOGICA

In vitro studies on human hematopoiesis

Stijn VanheeBart VandekerckhoveTessa Kerre

Pluripotent stem cell based gene therapy for hematological diseases

Stijn VanheeBart Vandekerckhove

A1 Journal Article in CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

2014

In vitro and in vivo functional evaluation of T-cells generated from WT1-TCR transduced human hematopoietic stem cells using the OP9-DL1 coculture system

Sarah BonteSYLVIA SNAUWAERTGlenn GoetgelukH StaussR StripeckeM HeemskerkYasmine Van CaeneghemGreet VerstichelStijn VanheeBart Vandekerckhove et al.

In vitro generation of mature, naive antigen-specific CD8⁺ T cells with a single T-cell receptor by agonist selection

SYLVIA SNAUWAERTGreet VerstichelSarah BonteGlenn GoetgelukStijn VanheeYasmine Van CaeneghemKatrien De MulderCarlo HeirmanHans StaussMiriam HM Heemskerk et al.

A1 Journal Article in LEUKEMIA

In vitro human embryonic stem cell hematopoiesis mimics MYB independent yolk sac hematopoiesis

Stijn VanheeKatrien De MulderYasmine Van CaeneghemNadine Van RoyBjörn MentenImke VelgheJan PhilippéTom TaghonGeorges LeclercqTessa Kerre et al.

2013

CMYB expression during human in vitro hematopoiesis

Stijn VanheeYasmine Van CaeneghemKatrien De MulderImke VelgheSylvie TaveirneNadine Van RoyBjörn MentenSYLVIA SNAUWAERTGreet VerstichelMelissa Dullaers et al.

In vitro generation of antigen-specific T-cells from CD34+haematopoietic progenitor cells: a new and promising immunotherapeutic strategy

SYLVIA SNAUWAERTS Van CoppernolleGreet VerstichelGlenn GoetgelukYasmine Van CaeneghemStijn VanheeImke VelgheJean PlumTessa KerreBart Vandekerckhove

Vpr content of HIV-1 virions determines infection of resting peripheral blood CD4⁺ lymphocytes

Anouk Van NuffelFrancis ImpensAnn BaeyensStijn VanheeWojciech WitkowskiElien VandermarliereHanne VanderstraetenEvelien NaessensKathleen Van LandeghemSophie Vermaut et al.

2012

Evaluation of the receptor for hyaluronic acid mediated motility as a tumour-specific antigen in AML

SYLVIA SNAUWAERTStijn VanheeYasmine Van CaeneghemGreet VerstichelGlenn GoetgelukImke VelgheBart VandekerckhoveTessa Kerre

Notch induces human T-cell receptor γδ+ thymocytes to differentiate along a parallel, highly proliferative and bipotent CD4 CD8 double-positive pathway

Stefanie Van CoppernolleStijn VanheeGreet VerstichelSYLVIA SNAUWAERTA van der SpekImke VelgheMieke SinnesaelMH HeemskerkTom TaghonGeorges Leclercq et al.

A1 Journal Article in LEUKEMIA

RHAMM/HMMR (CD168) is not an ideal target antigen for immunotherapy of acute myeloid leukemia

SYLVIA SNAUWAERTStijn VanheeGlenn GoetgelukGreet VerstichelYasmine Van CaeneghemImke VelgheJan PhilippéZwi N BernemanJean PlumTom Taghon et al.

A1 Journal Article in HAEMATOLOGICA-THE HEMATOLOGY JOURNAL

2011

Double positive and double negative TCR gamma delta plus cells independently generate mature functional TCR gamma delta plus cells in the human thymus

Stefanie Van CoppernolleStijn VanheeGreet VerstichelSYLVIA SNAUWAERTImke VelgheMieke SinnesaelA van der SpekTom TaghonGeorges LeclercqJean Plum et al.

In vitro generation of immune cells from pluripotent stem cells

Bart VandekerckhoveStijn VanheeStefanie Van CoppernolleSYLVIA SNAUWAERTImke VelgheTom TaghonGeorges LeclercqTessa KerreJean Plum

A1 Journal Article in FRONTIERS IN BIOSCIENCE-LANDMARK