Research Explorer

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Researcher

Steven Goossens

Publications & Research Data

Awards & Distinctions

120 Results

2025

A human-like glutaminase-free asparaginase is highly efficacious in ASNS-low leukemia and solid cancer mouse xenograft models

Maaike Van TrimpontAmanda M. SchalkKenneth HofkensEvelien PeetersSara T'SasKatrien VandemeulebroeckeYing SuAshley De LoeraAlyssa GarciaHui Chen et al.

A1 Journal Article in CANCER LETTERS

Development and validation of a high-throughput screening pipeline of compound libraries to target EMT

Sven JonckheereJoachim TaminauJamie AdamsJef HaerinckJordy De ConinckJeroen VerstappeKato De ClercqEvelien PeetersAlexander GheldofEva De Smedt et al.

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Genetic rescue of a subset of thyroid follicular cells restores thyroid function in dyshormonogenic duoxa-/- mice

Sami DjerbibHelmut GrasbergerSteven GoossensJody HaighLieven HaenebalckeTim PietersJukka KeroFrancoise MiotXavier De Deken

A1 Journal Article in THYROID

HNRNPC and m6A RNA methylation control oncogenic transcription and metabolism in T-cell leukemia

Jonas De KeselIgor FijalkowskiTim PietersCristina BorinKasper Thorhauge ChristensenManou WittouckJolien Van LaereLaura GuerreroLindy ReunesMarino Caruso et al.

A1 Journal Article in BLOOD

Modeling of glucocorticoid resistance in multiple myeloma reveals mechanisms and markers of glucocorticoid resistance

Bert LuyckxMélanie DerollezEleni StaessensAnnick VerheeDaria FijalkowskaPieter Van VlierbergheSteven GoossensDorien ClarisseKarolien De Bosscher

A1 Journal Article in BIOMEDICINE & PHARMACOTHERAPY

Peptide hydrogels as slow-release formulations of protein therapeutics : case study of asparaginase-loaded hydrogels

Hue VuEvelien PeetersKenneth HofkensKatrien VandemeulebroeckeSara T'SasCharlotte MartinSteven BalletRichard HoogenboomSteven GoossensTim Lammens et al.

A1 Journal Article in BIOMATERIALS SCIENCE

Profiling histone post-translational modifications to identify signatures of epigenetic drug response in T-cell acute lymphoblastic leukemia

Laura CorveleynLien ProvezOsman SatilmisNina RefhagenMattias LandforsWouter SleeckxBéatrice LintermansAmélie De MaesschalckRishi S. KotechaBarbara De Moerloose et al.

SOX11 skews T-cell development and synergizes with LMO2 and MYCN to form T-cell acute lymphoblastic leukemia in mouse models

André Pedro Pinto De AlmeidaKasper Thorhauge ChristensenIgor FijalkowskiMarlies Vanden BemptJan CoolsTom TaghonPanagiotis NtziachristosPieter Van VlierbergheSteven GoossensTim Pieters

Sox11-induced reprogramming of B2 cells to a B1a-like phenotype promotes Mantle Cell Lymphoma in mice

Tim PietersLuca PagliaroAndré Pedro Pinto De AlmeidaFritz OffnerTom TaghonPieter Van VlierbergheSteven Goossens

The role of KMT2A-complex members, PSIP1 and Menin, in T-cell acute lymphoblastic leukemia

Lisa DemoenSteven GoossensTim PietersKaat Durinck

The search for biomarkers that signal the onset of glucocorticoid resistance in multiple myeloma

Bert LuyckxKarolien De BosscherSteven GoossensDorien Clarisse

Underlying biology, challenges and emergent concepts in the treatment of relapsed and refractory pediatric T-cell acute lymphoblastic leukemia

Patrícia AmaralRhona ChristieDaisy O. F. GreshamEmma J. M. LucasLuyao Kevin XuLena BehrmannJonathan BondSofie DegermanFrederik W. van DelftSteven Goossens et al.

A1 Journal Article in LEUKEMIA

2024

A dual role for PSIP1/LEDGF in T cell acute lymphoblastic leukemia

Lisa DemoenFilip MatthijssensLindy ReunesBruno PalhaisBéatrice LintermansSara T'SasIgor FijalkowskiJoachim TaminauMuluembet Z. AkeleSiska Van Belle et al.

A1 Journal Article in SCIENCE ADVANCES

Dual targeting of MAPK and PI3K pathways unlocks redifferentiation of Braf-mutated thyroid cancer organoids

Helene LasolleAndrea SchiavoAdrien TourneurPierre GillotayBarbara de Faria da FonsecaLucieli CeolinOlivier MonestierBenilda AganahiLaura ChometteMarina Malta Letro Kizys et al.

A1 Journal Article in ONCOGENE

Functional evaluation of transcription factors in T-ALL : MYB and SOX11

André Pedro Pinto De AlmeidaPieter Van VlierbergheSteven GoossensTim PietersTom Taghon

Ikaros loss enhances pre-leukemic thymocyte self-renewal and drives T-all in mice

Maaike Van TrimpontSara T'SasTim LammensPieter Van VlierbergheTim PietersSteven Goossens

Myb overexpression synergizes with the loss of Pten and is a dependency factor and therapeutic target in T-cell lymphoblastic leukemia

André Pedro Pinto De AlmeidaSara T'SasLuca PagliaroIgor FijalkowskiWouter SleeckxHannah Van SteenbergeRaffaella ZamponiBéatrice LintermansWouter Van LoockeBruno Palhais et al.

A1 Journal Article in HEMASPHERE

PDXGhent : patient derived tumor xenografting mouse core facility Ghent

Liselot MusSteven GoossensTim LammensLindsey DevisscherPanagiotis NtziachristosOlivier De WeverFrédéric Clement

PDXGhent : patient derived tumor xenografting mouse Core Facility Ghent

Liselot MusSteven GoossensTim LammensLindsey DevisscherPanagiotis NtziachristosOlivier De WeverFrédéric Clement

Targeting hyperactive platelet-derived growth factor receptor-β signaling in T-cell acute lymphoblastic leukemia and lymphoma

Stien De ConinckRenate De SmedtBéatrice LintermansLindy ReunesHansen J. KosasihAlexandra ReekmansLauren M. BrownNadine Van RoyBruno PalhaisJuliette Roels et al.

A1 Journal Article in HAEMATOLOGICA

Tet2 is a tumor suppressor in the pre-leukemic phase of T-cell acute lymphoblastic leukemia

Stien De ConinckJuliette RoelsBéatrice LintermansSara T'SasTom TaghonDavid CurtisTim PietersSteven GoossensPieter Van Vlierberghe

A1 Journal Article in BLOOD ADVANCES

Unravelling novel key players in T-cell acute lymphoblastic leukemia and lymphoma

Stien De ConinckPieter Van VlierbergheSteven GoossensTim Pieters

ZEB2 drives intra-tumor heterogeneity and skin squamous cell carcinoma formation with distinct EMP transition states

Jeroen VerstappeNicolas SkrypekJordy De ConinckBieke SoenJoachim TaminauMarianthi TatariKenneth BruneelNele LoretKato De ClercqCaroline Van den Broecke et al.

A1 Journal Article in ISCIENCE

2023

A novel mammalian L-asparaginase with no L-glutaminase activity is highly efficacious against T-cell acute lymphoblastic leukemia in vivo

Maaike Van TrimpontAmanda SchalkEvelien PeetersTim LammensSteven GoossensArnon LaviePieter Van Vlierberghe

A role for IKZF1 in pre-leukemic T-all?

Maaike Van TrimpontTim LammensSteven GoossensPieter Van Vlierberghe

Epidrugs in cancer : epigenetic profiling to improve treamtent for T-cell lymphoblastic leukemia and lymphoma

Lien ProvezPieter Van VlierbergheSteven GoossensMaarten Dhaenens

In vivo stabilization of a less toxic asparaginase variant leads to a durable antitumor response in acute leukemia

Maaike Van TrimpontAmanda M. SchalkYanti De VisserHien Anh NguyenLindy ReunesKatrien VandemeulebroeckeEvelien PeetersYing SuHyun LeePhilip L. Lorenzi et al.

A1 Journal Article in HAEMATOLOGICA

Mutations in the histone methyltransferase Ezh2 drive context-dependent leukemia in Xenopus tropicalis

Dieter TulkensMarthe BoelensThomas NaertMarjolein CarronSuzan DemuynckSylviane DewaeleGert Van IsterdaelDavid CreytensTim PietersSteven Goossens et al.

A1 Journal Article in LEUKEMIA

The epithelial-mesenchymal plasticity landscape: principles of design and mechanisms of regulation

Jef HaerinckSteven GoossensGeert Berx

A1 Journal Article in NATURE REVIEWS GENETICS

2022

Direct and indirect anti-leukemic properties of Activity-on-Target interferons for the treatment of T-cell acute lymphoblastic leukemia

Steven GoossensAnje CauwelsTim PietersRenate De SmedtSara T'SasAndré Pedro Pinto De AlmeidaWillem DaneelsPieter Van VlierbergheJan Tavernier

A1 Journal Article in HAEMATOLOGICA

Distinct transcriptional programs in ascitic and solid cancer cells induce different responses to chemotherapy in high-grade serous ovarian cancer

Nele LoretNiels VandammeJordy De ConinckJoachim TaminauKato De ClercqGillian BlanckeSven JonckheereSteven GoossensKelly LemeireSofie De Prijck et al.

A1 Journal Article in MOLECULAR CANCER RESEARCH

Epithelial-mesenchymal transition (EMT) as a therapeutic target

Sven JonckheereJamie AdamsDominic De GrooteKyra CampbellGeert BerxSteven Goossens

A1 Journal Article in CELLS TISSUES ORGANS

MEF2C opposes Notch in lymphoid lineage decision and drives leukemia in the thymus

Kirsten Canté-BarrettMariska T. MeijerValentina CordoRico HagelaarWentao YangJiyang YuWillem K. SmitsMarloes E. NulleJoris P. JansenRob Pieters et al.

A1 Journal Article in JCI INSIGHT

Myb drives B-cell neoplasms and myeloid malignancies in vivo

Tim PietersAndré Pedro Pinto De AlmeidaSara T'SasKelly LemeireTino HochepiedGeert BerxAlex KentsisSteven GoossensPieter Van Vlierberghe

A1 Journal Article in BLOOD ADVANCES

Novel insights on the use of L-asparaginase as an efficient and safe anti-cancer therapy

Maaike Van TrimpontEvelien PeetersYanti De VisserAmanda M. SchalkVeerle MondelaersBarbara De MoerlooseArnon LavieTim LammensSteven GoossensPieter Van Vlierberghe

A1 Journal Article in CANCERS

Novel molecular insights and improved therapies in T-cell acute lymphoblastic leukemia

Maaike Van TrimpontPieter Van VlierbergheSteven Goossens

PDGFR-β as a new therapeutic target in T-cell acute lymphoblastic leukemia

Stien De ConinckRenate De SmedtBéatrice LintermansSteven GoossensPieter Van Vlierberghe

RRM2 enhances MYCN-driven neuroblastoma formation and acts as a synergistic target with CHK1 inhibition

Carolina de Carvalho NunesLisa DepestelLiselot MusKaylee M. KellerLouis DelhayeAmber LouwagieMuhammad RishfiAlex WhaleNeesha KaraSimon R. Andrews et al.

A1 Journal Article in SCIENCE ADVANCES

The role of TET2 in (pre-) leukemic T-ALL : TET2 to the rescue?

Stien De ConinckJuliette RoelsMorgan ThénozBéatrice LintermansSteven GoossensPieter Van Vlierberghe

Therapeutic targeting of ZEB1-mediated EMT in metastatic colorectal cancer

Sven JonckheereGeert BerxSteven Goossens

2021

Cyclin D2 overexpression drives B1a-derived MCL-like lymphoma in mice

Tim PietersSara T'SasStijn VanheeAndré Pedro Pinto De AlmeidaYasmine DriegeJuliette RoelsWouter Van LoockeWillem DaneelsMathijs BaensArnaud Marchand et al.

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

Interplay between the EMT transcription factors ZEB1 and ZEB2 regulates hematopoietic stem and progenitor cell differentiation and hematopoietic lineage fidelity

Jueqiong WangCarlos FarkasAissa BenyoucefCatherine CarmichaelKatharina HaighNick WongDanny HuylebroeckMarc P. StemmlerSimone BrabletzThomas Brabletz et al.

A1 Journal Article in PLOS BIOLOGY

Pancreas morphogenesis and homeostasis depends on tightly regulated Zeb1 levels in epithelial cells

Maria Lasierra LosadaMelissa PaulerNiels VandammeSteven GoossensGeert BerxMoritz LeppkesHarald SchuhwerkSimone BrabletzThomas BrabletzMarc P. Stemmler

A1 Journal Article in CELL DEATH DISCOVERY

RUNX2 regulates leukemic cell metabolism and chemotaxis in high-risk T cell acute lymphoblastic leukemia

Filip MatthijssensNitesh D. SharmaMonique NysusChristian K. NicklHuining KangDominique R. PerezBéatrice LintermansWouter Van LoockeJuliette RoelsSofie Peirs et al.

A1 Journal Article in JOURNAL OF CLINICAL INVESTIGATION

SOX11 functions as an oncogene in Lmo2-driven T-cell lymphoblastic leukemia (T-ALL)

André Pedro Pinto De AlmeidaTim PietersSara T'SasSteven GoossensPieter Van Vlierberghe

The spleen as a sanctuary site for residual leukemic cells following ABT-199 monotherapy in ETP-ALL

Alessandra Di GrandeSofie PeirsPaul D. DonovanMaaike Van TrimpontJulie MorscioBéatrice LintermansLindy ReunesNiels VandammeSteven GoossensHien Anh Nguyen et al.

A1 Journal Article in BLOOD ADVANCES

Unlike its paralog LEDGF/p75, HRP-2 is dispensable for MLL-R leukemogenesis but important for leukemic cell survival

Siska Van BelleSara El AshkarKateřina ČermákováFilip MatthijssensSteven GoossensAlessandro CanellaCourtney H. HodgesFrauke ChristJan De RijckPieter Van Vlierberghe et al.

A1 Journal Article in CELLS

2020

Aging of preleukemic thymocytes drives CpG island hypermethylation in T-cell acute lymphoblastic leukemia

Juliette RoelsMorgan ThénozBronislawa SzarzynskaMattias LandforsStien De ConinckLisa DemoenLien ProvezAnna KuchmiySteven StrubbeLindy Reunes et al.

Aging of preleukemic thymocytes drives CpG island hypermethylation in T-cell acute lymphoblastic leukemia

Juliette RoelsMorgan ThénozB SzarzyńskaM LandforsStien De ConinckLisa DemoenLien ProvezAnna KuchmiySteven StrubbeLindy Reunes et al.

A2 Journal Article in BLOOD CANCER DISCOVERY

Finding the 'key' in leukemia : PIM1 inhibition as a novel therapy in T-cell acute lymphoblastic leukemia

Renate De SmedtPieter Van VlierbergheSteven Goossens

Publisher correction : Zeb2 drives invasive and microbiota-dependent colon carcinoma

Karolina SlowickaIoanna PettaGillian BlanckeEsther HosteEmilie DumasMozes SzeHanna-Kaisa VikkulaEnrico RadaelliJody J. HaighSven Jonckheere et al.

Targeting cytokine- and therapy-induced PIM1 activation in preclinical models of T-cell acute lymphoblastic leukemia and lymphoma

Renate De SmedtJulie MorscioLindy ReunesJuliette RoelsValentina BardelliBéatrice LintermansWouter Van LoockeAfonso AlmeidaLaurence C. CheungRishi S. Kotecha et al.

A1 Journal Article in BLOOD

Teaching an old dog new tricks : activity-on-target interferon to treat T-cell acute lymphoblastic leukemia

Steven GoossensAnje CauwelsTim PietersWillem DaneelsPieter Van VlierbergheJan Tavernier

The EMT modulator SNAI1 contributes to AML pathogenesis via its interaction with LSD1

Catherine L. CarmichaelJueqiong WangThao NguyenOluseyi KolawoleAissa BenyoucefCharlotte De MazièreAnna MilneSona SamuelKevin Robert GillinderSoroor Hediyeh-zadeh et al.

A1 Journal Article in BLOOD

The EMT transcription factor ZEB2 promotes proliferation of primary and metastatic melanoma while suppressing an invasive, mesenchymal-like phenotype

Niels VandammeGeertrui DeneckerKenneth BruneelGillian BlanckeOzden AkayJoachim TaminauJordy De ConinckEva De SmedtNicolas SkrypekWouter Van Loocke et al.

A1 Journal Article in CANCER RESEARCH

Zeb2 drives invasive and microbiota-dependent colon carcinoma

Karolina SlowickaIoanna PettaGillian BlanckeEsther HosteEmilie DumasMozes SzeHanna-Kaisa VikkulaEnrico RadaelliJody J. HaighSven Jonckheere et al.

A1 Journal Article in NATURE CANCER

2019

Genetic characterization and therapeutic targeting of MYC-rearranged T cell acute lymphoblastic leukaemia

Gloria MilaniFilip MatthijssensWouter Van LoockeKaat DurinckJuliette RoelsSofie PeirsMorgan ThénozTim PietersLindy ReunesBéatrice Lintermans et al.

A1 Journal Article in BRITISH JOURNAL OF HAEMATOLOGY

Novel strategy for rapid functional in vivo validation of oncogenic drivers in haematological malignancies

Tim PietersSara T'SasLisa DemoenAndré Pedro Pinto De AlmeidaLieven HaenebalckeFilip MatthijssensKelly LemeireJinke D'HontFrédérique VanrockeghemTino Hochepied et al.

A1 Journal Article in SCIENTIFIC REPORTS

Targeting steroid resistance in T-cell acute lymphoblastic leukemia

Renate De SmedtJulie MorscioSteven GoossensPieter Van Vlierberghe

A1 Journal Article in BLOOD REVIEWS

USP7 cooperates with NOTCH1 to drive the oncogenic transcriptional program in T-cell leukemia

Qi JinCarlos A MartinezKelly M ArcipowskiYixing ZhuBlanca T Gutierrez-DiazKenneth K WangMegan R JohnsonAndrew G VolkFeng WangJian Wu et al.

A1 Journal Article in CLINICAL CANCER RESEARCH

ZEB2 and LMO2 drive immature T-cell lymphoblastic leukemia via distinct oncogenic mechanisms

Steven GoossensJueqiong WangCedric TremblayJelle De MedtsSara T'SasThao NguyenJesslyn SawKatharina HaighDavid J CurtisPieter Van Vlierberghe et al.

A1 Journal Article in HAEMATOLOGICA

2018

A knock-in/knock-out mouse model of HSPB8-associated distal hereditary motor neuropathy and myopathy reveals toxic gain-of-function of mutant Hspb8

Delphine BouhyManisha JunejaIstvan KatonaAnne HolmgrenBob AsselberghVicky De WinterTino HochepiedSteven GoossensJody J HaighClaude Libert et al.

A1 Journal Article in ACTA NEUROPATHOLOGICA

A novel L-asparaginase with low L-glutaminase coactivity is highly efficacious against both T- and B-cell acute lymphoblastic leukemias in vivo

Hien Anh NguyenYing SuJenny Yu ZhangAleksandar AntanasijevicMichael CaffreyAmanda M SchalkLi LiuDamiano RondelliAnnie OhDolores L Mahmud et al.

A1 Journal Article in CANCER RESEARCH

Expressed repetitive elements are broadly applicable reference targets for normalization of reverse transcription-qPCR data in mice

Marjolijn RenardSuzanne VanhauwaertMarine VanhomwegenAli RihaniNiels VandammeSteven GoossensGeert BerxPieter Van VlierbergheJody J HaighBieke Decaesteker et al.

A1 Journal Article in SCIENTIFIC REPORTS

LEDGF/p75 is dispensable for hematopoiesis but essential for MLL-rearranged leukemogenesis

Sara El AshkarJuerg SchwallerTim PietersSteven GoossensJonas DemeulemeesterFrauke ChristSiska Van BelleSabine JugeNancy BoeckxAlan Engelman et al.

A1 Journal Article in BLOOD

Pre-clinical evaluation of second generation PIM inhibitors for the treatment of T-cell acute lymphoblastic leukemia and lymphoma

Renate De SmedtSofie PeirsJulie MorscioFilip MatthijssensJuliette RoelsLindy ReunesBéatrice LintermansSteven GoossensTim LammensNadine Van Roy et al.

A1 Journal Article in HAEMATOLOGICA

ZEB proteins in leukemia : friends, foes, or friendly foes?

Bieke SoenNiels VandammeGeert BerxJürg SchwallerPieter Van VlierbergheSteven Goossens

A2 Journal Article in HEMASPHERE

ZEB2 stably represses RAB25 expression through epigenetic regulation by SIRT1 and DNMTs during epithelial-to-mesenchymal transition

Nicolas SkrypekKenneth BruneelCindy VandewalleEva De SmedtBieke SoenNele LoretJoachim TaminauSteven GoossensNiels VandammeGeert Berx

A1 Journal Article in EPIGENETICS & CHROMATIN

2017

EMT transcription factors in cancer development re-evaluated : beyond EMT and MET

Steven GoossensNiels VandammePieter Van VlierbergheGeert Berx

A1 Journal Article in BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Epithelial-to-mesenchymal transition : epigenetic reprogramming driving cellular plasticity

Nicolas SkrypekSteven GoossensEva De SmedtNiels VandammeGeert Berx

A1 Journal Article in TRENDS IN GENETICS

Novel oncogenic noncoding mutations in T-ALL

Steven GoossensPieter Van Vlierberghe

Editorial material

Oncogenic ZEB2 activation drives sensitivity toward KDM1A inhibition in T-cell acute lymphoblastic leukemia

Steven GoossensSofie PeirsWouter Van LoockeJueqiong WangMina TakawyFilip MatthijssensStefan E SondereggerKatharina HaighThao NguyenNiels Vandamme et al.

A1 Journal Article in BLOOD

Structure-function studies in mouse embryonic stem cells using recombinase-mediated cassette exchange

Tim PietersLieven HaenebalckeKenneth BruneelNiels VandammeTino HochepiedJolanda van HengelDagmar WirthGeert BerxJody J HaighFrans Van Roy et al.

A1 Journal Article in JOVE-JOURNAL OF VISUALIZED EXPERIMENTS

Targeting BET proteins improves the therapeutic efficacy of BCL-2 inhibition in T-cell acute lymphoblastic leukemia

Sofie PeirsV FrismantasFilip MatthijssensW Van LoockeTim PietersNiels VandammeBéatrice LintermansMP DobayGeert BerxBruce Poppe et al.

A1 Journal Article in LEUKEMIA

The EMT transcription factor Zeb2 controls adult murine hematopoietic differentiation by regulating cytokine signaling

Jin LiTamara RiedtSteven GoossensCarmen Carrillo GarciaSabrina SzczepanskiMaria BrandesTim PietersLinne DobroschInes GuetgemannNatalie Farla et al.

A1 Journal Article in BLOOD

Zeb2 regulates cell fate at the exit from epiblast state in mouse embryonic stem cells

Agata StryjewskaRuben DriesTim PietersGriet VerstappenAndrea ConidiKathleen CoddensAnnick FrancisLieve UmansWilfred FJ van IJckenGeert Berx et al.

A1 Journal Article in STEM CELLS

2016

Characterization of new transgenic mouse models for two Charcot-Marie-tooth-causing HspB1 mutations using the Rosa26 locus

Delphine BouhyThomas GeuensVicky De WinterLeonardo De Almeida SouzaIstvan KatonaJoachim WeisTino HochepiedSteven GoossensJody HaighSophie Janssens et al.

A2 Journal Article in JOURNAL OF NEUROMUSCULAR DISEASES

Cyclin D2 overexpression recapitulates mantle cell lymphoma in mice

Tim PietersSteven GoossensSara T'SasGeert BerxJody J HaighPieter Van Vlierberghe

Fast generation of conditional ROSA26-based mouse models that recapitulate genomic events in human T-ALL

Tim PietersSteven GoossensSara T'SasLieven HaenebalckeTino HochepiedBéatrice LintermansSofie PeirsFilip MatthijssensJ HaighGeert Berx et al.

LIN28B is over-expressed in specific subtypes of pediatric leukemia and regulates lncRNA H19

Hetty HelsmoortelBarbara De MoerlooseTim PietersFarzaneh GhazaviSilvia BresolinHelene CaveAndrica de VriesValerie de HaasChristian FlothoVeerle Labarque et al.

A1 Journal Article in HAEMATOLOGICA

Oncogenic ZEB2 activation drives sensitivity towards LSD1 inhibition in T-Cell acute lymphoblastic leukemia

Steven GoossensSofie PeirsGeert BerxPieter Van VlierbergheJody J Haigh

Overcoming steroid resistance in T cell acute lymphoblastic leukemia

Steven GoossensPieter Van Vlierberghe

Editorial material

p120 Catenin-mediated stabilization of E-cadherin is essential for primitive endoderm specification

Tim PietersSteven GoossensLieven HaenebalckeVanessa AndriesAgata StryjewskaRiet De RyckeKelly LemeireTino HochepiedDanny HuylebroeckGeert Berx et al.

A1 Journal Article in PLOS GENETICS

2015

Alpha-catenins control cardiomyocyte proliferation by regulating Yap activity

Jifen LiErhe GaoAlexia ViteRoslyn YiLudovic GomezSteven GoossensFrans Van RoyGlenn L Radice

A1 Journal Article in CIRCULATION RESEARCH

Immunohistological description of nongestational ovarian choriocarcinoma in two female mice with conditional loss of Trp53 driven by the Tie2 promoter

V CastiglioniMorvarid Farhang GhahremaniSteven GoossensM De MaglieM ArdizzoneJody HaighE Radaelli

A1 Journal Article in VETERINARY PATHOLOGY

MicroRNA-193b-3p acts as a tumor suppressor by targeting the MYB oncogene in T-cell acute lymphoblastic leukemia

Evelien MetsJoni Van der MeulenGert Van PeerMichael BoicePieter MestdaghInge Van de WalleTim LammensSteven GoossensBarbara De MoerlooseYves Benoit et al.

A1 Journal Article in LEUKEMIA

Novel biological insights in T-cell acute lymphoblastic leukemia

Kaat DurinckSteven GoossensSofie PeirsAnnelynn WallaertWouter Van LoockeFilip MatthijssensTim PietersGloria MilaniTim LammensPieter Rondou et al.

A1 Journal Article in EXPERIMENTAL HEMATOLOGY

Strategies to rescue the consequences of inducible arginase-1 deficiency in mice

Laurel L BallantyneYuan Yan SinTim St AmandJoshua SiSteven GoossensLieven HaenebalckeJody HaighLianna KyriakopoulouAndrea SchulzeColin D Funk

A1 Journal Article in PLOS ONE

Terminal NK cell maturation is controlled by concerted actions of T-bet and Zeb2 and is essential for melanoma rejection

Mary van HeldenSteven GoossensCécile DaussyAnne-Laure MathieuFabrice FaureAntoine MarçaisNiels VandammeNatalie FarlaKatia MayolSébastien Viel et al.

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

Transcriptional repressor ZEB2 promotes terminal differentiation of CD8⁺ effector and memory T cell populations during infection

Kyla D OmilusikJ Adam BestBingfei YuSteven GoossensAlexander WeidemannJessica V NguyenEve SeuntjensAgata StryjewskaChristiane ZweierRahul Roychoudhuri et al.

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

ZEB2 drives immature T-cell lymphoblastic leukaemia development via enhanced tumour-initiating potential and IL-7 receptor signalling

Steven GoossensEnrico RadaelliOdile BlanchetKaat DurinckJoni Van der MeulenSofie PeirsTom TaghonCedric S TremblayMagdaline CostaMorvarid Farhang Ghahremani et al.

A1 Journal Article in NATURE COMMUNICATIONS

2014

ABT-199 mediated inhibition of BCL-2 as a novel therapeutic strategy in early immature T-cell acute lymphoblastic leukemia

Sofie PeirsFilip MatthijssensSteven GoossensKirsten Canté-BarrettTim LammensBarbara De MoerlooseYves BenoitJean SoulierBruce PoppeTom Taghon et al.

ABT-199 mediated inhibition of BCL-2 as a novel therapeutic strategy in T-cell acute lymphoblastic leukemia

Sofie PeirsFilip MatthijssensSteven GoossensInge Van de WalleKatia RuggeroCharles E de BockSandrine DegryseKirsten Canté-BarrettDelphine BriotEmmanuelle Clappier et al.

A1 Journal Article in BLOOD

Controlling pre-leukemic thymocyte self-renewal

Steven GoossensPieter Van Vlierberghe

Editorial material

Loss of autocrine endothelial-derived VEGF significantly reduces hemangiosarcoma development in conditional p53-deficient mice

Morvarid Farhang GhahremaniEnrico RadaelliKatharina HaighSona BartunkovaLieven HaenebalckeJean-Christophe MarineSteven GoossensJody Haigh

A1 Journal Article in CELL CYCLE

MicroRNA-128-3p is a novel oncomiR targeting PHF6 in T-cell acute lymphoblastic leukemia

Evelien MetsGert Van PeerJoni Van der MeulenMichael BoiceTom TaghonSteven GoossensPieter MestdaghYves BenoitBarbara De MoerlooseNadine Van Roy et al.

A1 Journal Article in HAEMATOLOGICA

ZEB2-transgene expression in the epidermis compromises the integrity of the epidermal barrier through the repression of different tight junction proteins

Marianthi TatariBram De CraeneBieke SoenJoachim TaminauPetra VermassenSteven GoossensKatharina HaighSilvia CazzolaJo LambertDanny Huylebroeck et al.

A1 Journal Article in CELLULAR AND MOLECULAR LIFE SCIENCES

2013

Beta-actin is involved in modulating erythropoiesis during development by fine-tuning Gata2 expression levels

Davina TondeleirBenjamin DrogatKarolina SlowickaKarima BakkaliSona BartunkovaSteven GoossensJody HaighChristophe Ampe

A1 Journal Article in PLOS ONE

Directed migration of cortical interneurons depends on the cell-autonomous action of Sip1

Veronique van den BergheElke StappersBram VandesandeJordane DimidschsteinRoel KroesAnnick FrancisAndrea ConidiFlore LesageRuben DriesSilvia Cazzola et al.

A1 Journal Article in NEURON

Efficient ROSA26-based conditional and/or inducible transgenesis using RMCE-compatible F1 hybrid mouse embryonic stem cells

Lieven HaenebalckeSteven GoossensMichaël NaessensNatascha KruseMorvarid Farhang GhahremaniSona BartunkovaKatharina HaighTim PietersPieterjan DierickxBenjamin Drogat et al.

A1 Journal Article in STEM CELL REVIEWS AND REPORTS

p53 promotes VEGF expression and angiogenesis in the absence of an intact p21-Rb pathway

Morvarid Farhang GhahremaniSteven GoossensD NittnerX BisteauSona BartunkovaA ZwolinskaPaco HulpiauKatharina HaighLieven HaenebalckeBenjamin Drogat et al.

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

The p53 family and VEGF regulation: 'It's complicated'

Morvarid Farhang GhahremaniSteven GoossensJody Haigh

Editorial material

The ROSA26-iPSC mouse : a conditional, inducible, and exchangeable resource for studying cellular (de)differentiation

Lieven HaenebalckeSteven GoossensPieterjan DierickxSona BartunkovaJinke D'HontKatharina HaighTino HochepiedDagmar WirthAndras NagyJody Haigh

A1 Journal Article in CELL REPORTS

2012

Loss of αT-catenin alters the hybrid adhering junctions in the heart and leads to dilated cardiomyopathy and ventricular arrhythmia following acute ischemia

Jifen LiSteven GoossensJolanda van HengelErhe GaoLan ChengKoen TybergheinXiying ShangRiet De RyckeFrans Van RoyGlenn L Radice

A1 Journal Article in JOURNAL OF CELL SCIENCE

The role of EMT modulators in hematopoiesis and leukemic transformation

Steven GoossensJody Haigh

Bookchapter in Hematology : science and practice

Tissue-wide overexpression of alpha-T-catenin results in aberrant trophoblast invasion but does not cause embryonic mortality in mice

Koen TybergheinSteven GoossensJody HaighFrans Van RoyJolanda van Hengel

A1 Journal Article in PLACENTA

2011

A vascular niche and a VEGF-Nrp1 loop regulate the initiation and stemness of skin tumours

Benjamin BeckGregory DriessensSteven GoossensKhalil Kass YoussefAnna KuchnioAmélie CaauwePanagiota A SotiropoulouSonja LogesGaelle LapougeAurélie Candi et al.

A1 Journal Article in NATURE

The EMT regulator Zeb2/Sip1 is essential for murine embryonic hematopoietic stem/progenitor cell differentiation and mobilization

Steven GoossensViktor JanzenSona BartunkovaTomomasa YokomizoBenjamin DrogatMihaela CrisanKatharina HaighEve SeuntjensLieve UmansTamara Riedt et al.

A1 Journal Article in BLOOD

2010

Increased skeletal VEGF enhances β-catenin activity and results in excessively ossified bones

Christa MaesSteven GoossensSona BartunkovaBenjamin DrogatLieven CoenegrachtsIngrid StockmansKaren MoermansOmar NyabiKatharina HaighMichaël Naessens et al.

A1 Journal Article in EMBO JOURNAL

Vegf regulates embryonic erythroid development through Gata1 modulation

Benjamin DrogatJoanna KaluckaLaura GutierrezHamida HammadSteven GoossensMorvarid Farhang GhahremaniSona BartunkovaKatharina HaighKim DeswarteOmar Nyabi et al.

A1 Journal Article in BLOOD

2009

Efficient mouse transgenesis using Gateway-compatible ROSA26 locus targeting vectors and F1 hybrid ES cells

Omar NyabiMichaël NaessensKatharina HaighAgnieszka GembarskaSteven GoossensMarion MaetensSarah De ClercqBenjamin DrogatLieven HaenebalckeSona Bartunkova et al.

A1 Journal Article in NUCLEIC ACIDS RESEARCH

2008

Plakophilin-3-deficient mice develop hair coat abnormalities and are prone to cutaneous inflammation

Tatyana SklyarovaStefan BonnéPetra D'HoogeGeertrui DeneckerSteven GoossensRiet De RyckeGaetan BorgonieMichael BöslFrans Van RoyJolanda van Hengel

A1 Journal Article in JOURNAL OF INVESTIGATIVE DERMATOLOGY

2007

A unique and specific interaction between alpha T-catenin and plakophilin-2 in the area composita, the mixed-type junctional structure of cardiac intercalated discs

Steven GoossensBarbara JanssensStefan BonnéRiet De RyckeFilip BraetJolanda van HengelFrans Van Roy

A1 Journal Article in JOURNAL OF CELL SCIENCE

Alpha-T-catenin (CTNNA3) displays turnour specific monoallelic expression in urothelial carcinoma of the bladder

M MEEHANA MELVINE GALLAGHERJ SMITHA MC GOLDRICKC MOSSSteven GoossensM HARRISONE KAYJ FITZPATRICK et al.

A1 Journal Article in GENES CHROMOSOMES & CANCER

Truncated isoform of mouse alpha T-catenin is testis-restricted in expression and function

Steven GoossensBarbara JanssensGriet VanpouckeRiet De RyckeJ VAN HENGELFrans Van Roy

A1 Journal Article in FASEB JOURNAL

2005

Cadherin-mediated cell-cell adhesion in the testis

Steven GoossensFrans Van Roy

A1 Journal Article in FRONTIERS IN BIOSCIENCE

2004

alpha-T-catenin is expressed in human brain and interacts with the Wnt signaling pathway but is not responsible for linkage to chromosome 10 in Alzheimer's disease

V BUSBYSteven GoossensP NOWOTNYG HAMILTONS SMEMOD HAROLDD TURICL JEHUA MYERSM WOMICK et al.

A1 Journal Article in NEUROMOLECULAR MEDICINE

GATA-4 and MEF2C transcription factors control the tissue-specific expression of the αT-catenin gene CTNNA3

Griet VanpouckeSteven GoossensBram De CraeneBarbara GilbertFrans Van RoyGeert Berx

A1 Journal Article in NUCLEIC ACIDS RESEARCH

2003

Assessment of the CTNNA3 gene encoding human alpha T-catenin regarding its involvement in dilated cardiomyopathy

Barbara JanssensB MOHAPATRAM VATTASteven GoossensGriet VanpouckePatrick KoolsTony MontoyeJolanda van HengelNE BOWLESFrans Van Roy et al.

A1 Journal Article in HUMAN GENETICS

2001

alpha T-Catenin: a novel tissue-specific beta-catenin-binding protein mediating strong cell-cell adhesion.

Barbara JanssensSteven GoossensK STAESB GILBERTJolanda van HengelC COLPAERTErik BruyneelMarcus MareelFrans Van Roy

A1 Journal Article in JOURNAL OF CELL SCIENCE