Research Explorer

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Researcher

Steven Goossens

90 Results

2022

Direct and indirect anti-leukemic properties of Activity-on-Target interferons for the treatment of T-cell acute lymphoblastic leukemia

Steven GoossensAnje CauwelsTim PietersRenate De SmedtSara T'SasAndré Pedro Pinto De AlmeidaWillem DaneelsPieter Van VlierbergheJan Tavernier

A1 Journal Article in HAEMATOLOGICA

Distinct transcriptional programs in ascitic and solid cancer cells induce different responses to chemotherapy in high-grade serous ovarian cancer

Nele LoretNiels VandammeJordy De ConinckJoachim TaminauKato De ClercqGillian BlanckeSven JonckheereSteven GoossensKelly LemeireSofie De PrijckKevin VerstaenRuth SeurinckJo Van DorpeSteven WeyersHannelore DenysKoen Van de VijverBart LambrechtPhilippe TummersYvan SaeysGeert Berx

A1 Journal Article in MOLECULAR CANCER RESEARCH

Epithelial-mesenchymal transition (EMT) as a therapeutic target

Sven JonckheereDominic De GrooteGeert BerxSteven Goossens

A1 Journal Article in CELLS TISSUES ORGANS

In vivo stabilization of a less toxic asparaginase variant leads to a durable anti-tumor response in acute leukemia

Maaike Van TrimpontYanti De VisserLindy ReunesKatrien VandemeulebroeckeEvelien PeetersVeerle MondelaersBarbara De MoerlooseTim LammensSteven GoossensPieter Van Vlierberghe

A1 Journal Article in HAEMATOLOGICA

MEF2C opposes Notch in lymphoid lineage decision and drives leukemia in the thymus

Steven Goossens

A1 Journal Article in JCI INSIGHT

Myb drives B-cell neoplasms and myeloid malignancies in vivo

Tim PietersAndré Pedro Pinto De AlmeidaSara T'SasKelly LemeireTino HochepiedGeert BerxSteven GoossensPieter Van Vlierberghe

A1 Journal Article in BLOOD ADVANCES

Novel insights on the use of L-asparaginase as an efficient and safe anti-cancer therapy

Maaike Van TrimpontEvelien PeetersYanti De VisserVeerle MondelaersBarbara De MoerlooseTim LammensSteven GoossensPieter Van Vlierberghe

A1 Journal Article in CANCERS

Novel molecular insights and improved therapies in T-cell acute lymphoblastic leukemia

Maaike Van TrimpontPieter Van VlierbergheSteven Goossens

RRM2 enhances MYCN-driven neuroblastoma formation and acts as a synergistic target with CHK1 inhibition

Carolina de Carvalho NunesLisa DepestelLiselot MusLouis DelhayeAmber LouwagieMuhammad RishfiFanny De VloedEllen SandersAline EggermontSarah-Lee BekaertWouter Van LoockeJan Willem BekGivani DewynSiebe LoontiensGert Van IsterdaelBieke DecaestekerLaurentijn TillemanFilip Van NieuwerburghVanessa VermeirssenChristophe Van NesteBart GhesquièreSteven GoossensSven EyckermanKatleen De PreterBram De WildeKaat DurinckFranki Speleman

U Journal Article in Science Advances

Therapeutic targeting of ZEB1-mediated EMT in metastatic colorectal cancer

Sven JonckheereGeert BerxSteven Goossens

2021

Cyclin D2 overexpression drives B1a-derived MCL-like lymphoma in mice

Tim PietersSara T'SasStijn VanheeAndré Pedro Pinto De AlmeidaYasmine DriegeJuliette RoelsWouter Van LoockeWillem DaneelsMaaike Van TrimpontFilip MatthijssensJulie MorscioKelly LemeireBéatrice LintermansLindy ReunesFritz OffnerJo Van DorpeTino HochepiedGeert BerxRudi BeyaertJens StaalPieter Van VlierbergheSteven Goossens

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

Interplay between the EMT transcription factors ZEB1 and ZEB2 regulates hematopoietic stem and progenitor cell differentiation and hematopoietic lineage fidelity

Steven GoossensGeert Berx

A1 Journal Article in PLOS BIOLOGY

Pancreas morphogenesis and homeostasis depends on tightly regulated Zeb1 levels in epithelial cells

Niels VandammeSteven GoossensGeert Berx

A1 Journal Article in CELL DEATH DISCOVERY

RUNX2 regulates leukemic cell metabolism and chemotaxis in high-risk T cell acute lymphoblastic leukemia

Filip MatthijssensBéatrice LintermansWouter Van LoockeJuliette RoelsSofie PeirsLisa DemoenTim PietersLindy ReunesTim LammensBarbara De MoerlooseFilip Van NieuwerburghDieter DeforceMartijn RisseeuwSerge Van CalenberghSteven GoossensPieter Van Vlierberghe

A1 Journal Article in JOURNAL OF CLINICAL INVESTIGATION

SOX11 functions as an oncogene in Lmo2-driven T-cell lymphoblastic leukemia (T-ALL)

André Pedro Pinto De AlmeidaTim PietersSara T'SasSteven GoossensPieter Van Vlierberghe

The spleen as a sanctuary site for residual leukemic cells following ABT-199 monotherapy in ETP-ALL

Sofie PeirsMaaike Van TrimpontJulie MorscioBéatrice LintermansLindy ReunesNiels VandammeSteven GoossensPieter Van Vlierberghe

A1 Journal Article in BLOOD ADVANCES

Unlike its paralog LEDGF/p75, HRP-2 is dispensable for MLL-R leukemogenesis but important for leukemic cell survival

Filip MatthijssensSteven GoossensPieter Van Vlierberghe

A1 Journal Article in CELLS

2020

Aging of preleukemic thymocytes drives CpG island hypermethylation in T-cell acute lymphoblastic leukemia

Juliette RoelsMorgan ThénozStien De ConinckLisa DemoenLien ProvezAnna KuchmiySteven StrubbeLindy ReunesTim PietersFilip MatthijssensWouter Van LoockeTim LammensBarbara De MoerlooseSteven GoossensTom TaghonPieter Van Vlierberghe

Aging of preleukemic thymocytes drives CpG island hypermethylation in T-cell acute lymphoblastic leukemia

Juliette RoelsMorgan ThénozStien De ConinckLisa DemoenLien ProvezAnna KuchmiySteven StrubbeLindy ReunesTim PietersFilip MatthijssensWouter Van LoockeTim LammensBarbara De MoerlooseDieter DeforceFilip Van NieuwerburghSteven GoossensTom TaghonPieter Van Vlierberghe

A2 Journal Article in BLOOD CANCER DISCOVERY

Finding the 'key' in leukemia : PIM1 inhibition as a novel therapy in T-cell acute lymphoblastic leukemia

Renate De SmedtPieter Van VlierbergheSteven Goossens

Publisher correction : Zeb2 drives invasive and microbiota-dependent colon carcinoma

Karolina SlowickaIoanna PettaGillian BlanckeEsther HosteEmilie DumasMozes SzeHanna-Kaisa VikkulaSven JonckheereJoachim TaminauNiels VandammeAndy WullaertPieter Van VlierbergheBart LambrechtChris CallewaertSteven GoossensGeert BerxLars VereeckeGeert van Loo

Targeting cytokine- and therapy-induced PIM1 activation in preclinical models of T-cell acute lymphoblastic leukemia and lymphoma

Renate De SmedtJulie MorscioLindy ReunesJuliette RoelsBéatrice LintermansWouter Van LoockeTim LammensNadine Van RoyBarbara De MoerlooseTom TaghonSteven GoossensPieter Van Vlierberghe

A1 Journal Article in BLOOD

Teaching an old dog new tricks : activity-on-target interferon to treat T-cell acute lymphoblastic leukemia

Steven GoossensAnje CauwelsTim PietersWillem DaneelsPieter Van VlierbergheJan Tavernier

The EMT modulator SNAI1 contributes to AML pathogenesis via its interaction with LSD1

Tim LammensBéatrice LintermansPieter Van VlierbergheGeert BerxSteven Goossens

A1 Journal Article in BLOOD

The EMT transcription factor ZEB2 promotes proliferation of primary and metastatic melanoma while suppressing an invasive, mesenchymal-like phenotype

Niels VandammeKenneth BruneelGillian BlanckeOzden AkayJoachim TaminauJordy De ConinckEva De SmedtNicolas SkrypekWouter Van LoockeLieve BrochezVanessa AndriesPieter Van VlierbergheSteven GoossensGeert Berx

A1 Journal Article in CANCER RESEARCH

Zeb2 drives invasive and microbiota-dependent colon carcinoma

Karolina SlowickaIoanna PettaGillian BlanckeEsther HosteEmilie DumasMozes SzeHanna-Kaisa VikkulaSven JonckheereJoachim TaminauNiels VandammeAndy WullaertPieter Van VlierbergheBart LambrechtChris CallewaertSteven GoossensGeert BerxLars VereeckeGeert van Loo

A1 Journal Article in NATURE CANCER

2019

Genetic characterization and therapeutic targeting of MYC-rearranged T cell acute lymphoblastic leukaemia

Gloria MilaniFilip MatthijssensWouter Van LoockeKaat DurinckJuliette RoelsSofie PeirsMorgan ThénozTim PietersLindy ReunesBéatrice LintermansNiels VandammeTim LammensNadine Van RoyFilip Van NieuwerburghDieter DeforceBarbara De MoerlooseYves BenoitSteven GoossensGeert BerxPieter Van Vlierberghe

A1 Journal Article in BRITISH JOURNAL OF HAEMATOLOGY

Novel strategy for rapid functional in vivo validation of oncogenic drivers in haematological malignancies

Tim PietersSara T'SasLisa DemoenAndré Pedro Pinto De AlmeidaLieven HaenebalckeFilip MatthijssensKelly LemeireJinke D'HontFrédérique VanrockeghemTino HochepiedBéatrice LintermansLindy ReunesTim LammensGeert BerxSteven GoossensPieter Van Vlierberghe

A1 Journal Article in SCIENTIFIC REPORTS

Targeting steroid resistance in T-cell acute lymphoblastic leukemia

Renate De SmedtJulie MorscioSteven GoossensPieter Van Vlierberghe

A1 Journal Article in BLOOD REVIEWS

USP7 cooperates with NOTCH1 to drive the oncogenic transcriptional program in T-cell leukemia

Sofie PeirsNiels VandammeGeert BerxSteven GoossensPieter Van Vlierberghe

A1 Journal Article in CLINICAL CANCER RESEARCH

ZEB2 and LMO2 drive immature T-cell lymphoblastic leukemia via distinct oncogenic mechanisms

Steven GoossensJelle De MedtsSara T'SasPieter Van VlierbergheGeert BerxTom Taghon

A1 Journal Article in HAEMATOLOGICA

2018

A knock-in/knock-out mouse model of HSPB8-associated distal hereditary motor neuropathy and myopathy reveals toxic gain-of-function of mutant Hspb8

Tino HochepiedSteven GoossensClaude Libert

A1 Journal Article in ACTA NEUROPATHOLOGICA

A novel L-asparaginase with low L-glutaminase coactivity is highly efficacious against both T- and B-cell acute lymphoblastic leukemias in vivo

Sofie PeirsTim LammensVeerle MondelaersBarbara De MoerlooseSteven GoossensPieter Van Vlierberghe

A1 Journal Article in CANCER RESEARCH

Expressed repetitive elements are broadly applicable reference targets for normalization of reverse transcription-qPCR data in mice

Marjolijn RenardSuzanne VanhauwaertMarine VanhomwegenNiels VandammeSteven GoossensGeert BerxPieter Van VlierbergheBieke DecaestekerJolien Van LaereIrina LambertzFranki SpelemanJo VandesompeleAndy Willaert

A1 Journal Article in SCIENTIFIC REPORTS

LEDGF/p75 is dispensable for hematopoiesis but essential for MLL-rearranged leukemogenesis

Tim PietersSteven GoossensPieter Van Vlierberghe

A1 Journal Article in BLOOD

Pre-clinical evaluation of second generation PIM inhibitors for the treatment of T-cell acute lymphoblastic leukemia and lymphoma

Renate De SmedtSofie PeirsJulie MorscioFilip MatthijssensJuliette RoelsLindy ReunesBéatrice LintermansSteven GoossensTim LammensNadine Van RoyFilip Van NieuwerburghDieter DeforceBarbara De MoerlooseYves BenoitPieter Van Vlierberghe

A1 Journal Article in HAEMATOLOGICA

ZEB proteins in leukemia : friends, foes, or friendly foes?

Bieke SoenNiels VandammeGeert BerxPieter Van VlierbergheSteven Goossens

A2 Journal Article in HEMASPHERE

ZEB2 stably represses RAB25 expression through epigenetic regulation by SIRT1 and DNMTs during epithelial-to-mesenchymal transition

Nicolas SkrypekKenneth BruneelCindy VandewalleEva De SmedtBieke SoenNele LoretJoachim TaminauSteven GoossensNiels VandammeGeert Berx

A1 Journal Article in EPIGENETICS & CHROMATIN

2017

EMT transcription factors in cancer development re-evaluated : beyond EMT and MET

Steven GoossensNiels VandammePieter Van VlierbergheGeert Berx

A1 Journal Article in BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Epithelial-to-mesenchymal transition : epigenetic reprogramming driving cellular plasticity

Nicolas SkrypekSteven GoossensEva De SmedtNiels VandammeGeert Berx

A1 Journal Article in TRENDS IN GENETICS

Novel oncogenic noncoding mutations in T-ALL

Steven GoossensPieter Van Vlierberghe

Editorial material

Oncogenic ZEB2 activation drives sensitivity toward KDM1A inhibition in T-cell acute lymphoblastic leukemia

Steven GoossensSofie PeirsWouter Van LoockeFilip MatthijssensNiels VandammeFilip Van NieuwerburghDieter DeforceGeert BerxPieter Van Vlierberghe

A1 Journal Article in BLOOD

Structure-function studies in mouse embryonic stem cells using recombinase-mediated cassette exchange

Tim PietersLieven HaenebalckeKenneth BruneelNiels VandammeTino HochepiedJolanda van HengelGeert BerxFrans Van RoySteven Goossens

A1 Journal Article in JOVE-JOURNAL OF VISUALIZED EXPERIMENTS

Targeting BET proteins improves the therapeutic efficacy of BCL-2 inhibition in T-cell acute lymphoblastic leukemia

Sofie PeirsFilip MatthijssensTim PietersNiels VandammeBéatrice LintermansGeert BerxBruce PoppeSteven GoossensPieter Van Vlierberghe

A1 Journal Article in LEUKEMIA

The EMT transcription factor Zeb2 controls adult murine hematopoietic differentiation by regulating cytokine signaling

Steven GoossensTim PietersNatalie FarlaPaco Hulpiau

A1 Journal Article in BLOOD

Zeb2 regulates cell fate at the exit from epiblast state in mouse embryonic stem cells

Tim PietersGeert BerxSteven GoossensJody Haigh

A1 Journal Article in STEM CELLS

2016

Characterization of new transgenic mouse models for two Charcot-Marie-tooth-causing HspB1 mutations using the Rosa26 locus

Tino HochepiedSteven GoossensSophie Janssens

A2 Journal Article in JOURNAL OF NEUROMUSCULAR DISEASES

Cyclin D2 overexpression recapitulates mantle cell lymphoma in mice

Tim PietersSteven GoossensSara T'SasGeert BerxPieter Van Vlierberghe

Fast generation of conditional ROSA26-based mouse models that recapitulate genomic events in human T-ALL

Tim PietersSteven GoossensSara T'SasLieven HaenebalckeTino HochepiedBéatrice LintermansSofie PeirsFilip MatthijssensGeert BerxPieter Van Vlierberghe

LIN28B is over-expressed in specific subtypes of pediatric leukemia and regulates lncRNA H19

Hetty HelsmoortelBarbara De MoerlooseTim PietersFarzaneh GhazaviNadine Van RoyYves BenoitSteven GoossensGeert BerxFranki SpelemanPieter Van VlierbergheTim Lammens

A1 Journal Article in HAEMATOLOGICA

Oncogenic ZEB2 activation drives sensitivity towards LSD1 inhibition in T-Cell acute lymphoblastic leukemia

Steven GoossensSofie PeirsGeert BerxPieter Van Vlierberghe

Overcoming steroid resistance in T cell acute lymphoblastic leukemia

Steven GoossensPieter Van Vlierberghe

Editorial material

p120 Catenin-mediated stabilization of E-cadherin is essential for primitive endoderm specification

Tim PietersSteven GoossensLieven HaenebalckeVanessa AndriesRiet De RyckeKelly LemeireTino HochepiedGeert BerxJody HaighJolanda van HengelFrans Van Roy

A1 Journal Article in PLOS GENETICS

2015

Alpha-catenins control cardiomyocyte proliferation by regulating Yap activity

Steven GoossensFrans Van Roy

A1 Journal Article in CIRCULATION RESEARCH

Immunohistological description of nongestational ovarian choriocarcinoma in two female mice with conditional loss of Trp53 driven by the Tie2 promoter

Morvarid Farhang GhahremaniSteven GoossensJody Haigh

A1 Journal Article in VETERINARY PATHOLOGY

MicroRNA-193b-3p acts as a tumor suppressor by targeting the MYB oncogene in T-cell acute lymphoblastic leukemia

Evelien MetsJoni Van der MeulenGert Van PeerPieter MestdaghInge Van de WalleTim LammensSteven GoossensBarbara De MoerlooseYves BenoitNadine Van RoyBruce PoppeJo VandesompeleTom TaghonPieter RondouPieter Van VlierbergheFranki Speleman

A1 Journal Article in LEUKEMIA

Novel biological insights in T-cell acute lymphoblastic leukemia

Kaat DurinckSteven GoossensSofie PeirsAnnelynn WallaertWouter Van LoockeFilip MatthijssensTim PietersGloria MilaniTim LammensPieter RondouNadine Van RoyBarbara De MoerlooseYves BenoitFranki SpelemanBruce PoppePieter Van Vlierberghe

A1 Journal Article in EXPERIMENTAL HEMATOLOGY

Strategies to rescue the consequences of inducible arginase-1 deficiency in mice

Steven GoossensLieven HaenebalckeJody Haigh

A1 Journal Article in PLOS ONE

Terminal NK cell maturation is controlled by concerted actions of T-bet and Zeb2 and is essential for melanoma rejection

Mary van HeldenSteven GoossensNiels VandammeNatalie FarlaJody HaighBart LambrechtGeert Berx

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

Transcriptional repressor ZEB2 promotes terminal differentiation of CD8⁺ effector and memory T cell populations during infection

Steven Goossens

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

ZEB2 drives immature T-cell lymphoblastic leukaemia development via enhanced tumour-initiating potential and IL-7 receptor signalling

Steven GoossensKaat DurinckJoni Van der MeulenSofie PeirsTom TaghonJelle De MedtsSona BartunkovaNatalie FarlaTim PietersFilip MatthijssensNadine Van RoyKim DeswarteLieven HaenebalckePieter RondouKarolina SlowickaGeert BerxFranki SpelemanPieter Van VlierbergheJody Haigh

A1 Journal Article in NATURE COMMUNICATIONS

2014

ABT-199 mediated inhibition of BCL-2 as a novel therapeutic strategy in T-cell acute lymphoblastic leukemia

Sofie PeirsFilip MatthijssensSteven GoossensInge Van de WalleTim LammensBarbara De MoerlooseYves BenoitBruce PoppeTom TaghonFranki SpelemanPieter Van Vlierberghe

A1 Journal Article in BLOOD

ABT-199 mediated inhibition of BCL-2 as a novel therapeutic strategy in early immature T-cell acute lymphoblastic leukemia

Sofie PeirsFilip MatthijssensSteven GoossensTim LammensBarbara De MoerlooseYves BenoitBruce PoppeTom TaghonFranki SpelemanPieter Van Vlierberghe

Controlling pre-leukemic thymocyte self-renewal

Steven GoossensPieter Van Vlierberghe

Editorial material

Loss of autocrine endothelial-derived VEGF significantly reduces hemangiosarcoma development in conditional p53-deficient mice

Morvarid Farhang GhahremaniKatharina HaighSona BartunkovaLieven HaenebalckeJean-Christophe MarineSteven GoossensJody Haigh

A1 Journal Article in CELL CYCLE

MicroRNA-128-3p is a novel oncomiR targeting PHF6 in T-cell acute lymphoblastic leukemia

Evelien MetsGert Van PeerJoni Van der MeulenTom TaghonSteven GoossensPieter MestdaghYves BenoitBarbara De MoerlooseNadine Van RoyBruce PoppeJo VandesompelePieter Van VlierbergheFranki SpelemanPieter Rondou

A1 Journal Article in HAEMATOLOGICA

ZEB2-transgene expression in the epidermis compromises the integrity of the epidermal barrier through the repression of different tight junction proteins

Marianthi TatariBram De CraeneBieke SoenJoachim TaminauPetra VermassenSteven GoossensKatharina HaighJo LambertJody HaighGeert Berx

A1 Journal Article in CELLULAR AND MOLECULAR LIFE SCIENCES

2013

Beta-actin is involved in modulating erythropoiesis during development by fine-tuning Gata2 expression levels

Davina TondeleirBenjamin DrogatKarolina SlowickaKarima BakkaliSona BartunkovaSteven GoossensJody HaighChristophe Ampe

A1 Journal Article in PLOS ONE

Directed migration of cortical interneurons depends on the cell-autonomous action of Sip1

Geert BerxSteven GoossensJody Haigh

A1 Journal Article in NEURON

Efficient ROSA26-based conditional and/or inducible transgenesis using RMCE-compatible F1 hybrid mouse embryonic stem cells

Lieven HaenebalckeSteven GoossensMichaël NaessensMorvarid Farhang GhahremaniSona BartunkovaKatharina HaighTim PietersPieterjan DierickxBenjamin DrogatJody Haigh

A1 Journal Article in STEM CELL REVIEWS AND REPORTS

The ROSA26-iPSC mouse : a conditional, inducible, and exchangeable resource for studying cellular (de)differentiation

Lieven HaenebalckeSteven GoossensPieterjan DierickxSona BartunkovaJinke D'HontKatharina HaighTino HochepiedJody Haigh

A1 Journal Article in CELL REPORTS

The p53 family and VEGF regulation: 'It's complicated'

Morvarid Farhang GhahremaniSteven GoossensJody Haigh

Editorial material

p53 promotes VEGF expression and angiogenesis in the absence of an intact p21-Rb pathway

Morvarid Farhang GhahremaniSteven GoossensSona BartunkovaPaco HulpiauKatharina HaighLieven HaenebalckeBenjamin DrogatJean-Christophe MarineJody Haigh

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

2012

Loss of αT-catenin alters the hybrid adhering junctions in the heart and leads to dilated cardiomyopathy and ventricular arrhythmia following acute ischemia

Steven GoossensJolanda van HengelKoen TybergheinRiet De RyckeFrans Van Roy

A1 Journal Article in JOURNAL OF CELL SCIENCE

The role of EMT modulators in hematopoiesis and leukemic transformation

Steven GoossensJody Haigh

Bookchapter in Hematology : science and practice

Tissue-wide overexpression of alpha-T-catenin results in aberrant trophoblast invasion but does not cause embryonic mortality in mice

Koen TybergheinSteven GoossensJody HaighFrans Van RoyJolanda van Hengel

A1 Journal Article in PLACENTA

2011

A vascular niche and a VEGF-Nrp1 loop regulate the initiation and stemness of skin tumours

Steven GoossensJody Haigh

A1 Journal Article in NATURE

The EMT regulator Zeb2/Sip1 is essential for murine embryonic hematopoietic stem/progenitor cell differentiation and mobilization

Steven GoossensSona BartunkovaBenjamin DrogatKatharina HaighPieter BogaertLieven HaenebalckeGeert BerxJody Haigh

A1 Journal Article in BLOOD

2010

Increased skeletal VEGF enhances β-catenin activity and results in excessively ossified bones

Steven GoossensSona BartunkovaBenjamin DrogatKatharina HaighMichaël NaessensLieven HaenebalckeJody Haigh

A1 Journal Article in EMBO JOURNAL

Vegf regulates embryonic erythroid development through Gata1 modulation

Benjamin DrogatHamida HammadSteven GoossensMorvarid Farhang GhahremaniSona BartunkovaKatharina HaighKim DeswarteMichaël NaessensBart LambrechtJody Haigh

A1 Journal Article in BLOOD

2009

Efficient mouse transgenesis using Gateway-compatible ROSA26 locus targeting vectors and F1 hybrid ES cells

Michaël NaessensKatharina HaighAgnieszka GembarskaSteven GoossensSarah De ClercqBenjamin DrogatLieven HaenebalckeSona BartunkovaBram De CraeneMansour KarimiGeert BerxPierre HilsonJean-Christophe MarineJody Haigh

A1 Journal Article in NUCLEIC ACIDS RESEARCH

2008

Plakophilin-3-deficient mice develop hair coat abnormalities and are prone to cutaneous inflammation

Tatyana SklyarovaStefan BonnéSteven GoossensRiet De RyckeGaetan BorgonieFrans Van RoyJolanda van Hengel

A1 Journal Article in JOURNAL OF INVESTIGATIVE DERMATOLOGY

2007

A unique and specific interaction between alpha T-catenin and plakophilin-2 in the area composita, the mixed-type junctional structure of cardiac intercalated discs

Steven GoossensBarbara JanssensStefan BonnéRiet De RyckeFilip BraetJolanda van HengelFrans Van Roy

A1 Journal Article in JOURNAL OF CELL SCIENCE

Alpha-T-catenin (CTNNA3) displays turnour specific monoallelic expression in urothelial carcinoma of the bladder

Steven Goossens

A1 Journal Article in GENES CHROMOSOMES & CANCER

Truncated isoform of mouse alpha T-catenin is testis-restricted in expression and function

Steven GoossensBarbara JanssensGriet VanpouckeRiet De RyckeFrans Van Roy

A1 Journal Article in FASEB JOURNAL

2005

Cadherin-mediated cell-cell adhesion in the testis

Steven GoossensFrans Van Roy

A1 Journal Article in FRONTIERS IN BIOSCIENCE

2004

GATA-4 and MEF2C transcription factors control the tissue-specific expression of the αT-catenin gene CTNNA3

Griet VanpouckeSteven GoossensBram De CraeneBarbara GilbertFrans Van RoyGeert Berx

A1 Journal Article in NUCLEIC ACIDS RESEARCH

alpha-T-catenin is expressed in human brain and interacts with the Wnt signaling pathway but is not responsible for linkage to chromosome 10 in Alzheimer's disease

Steven GoossensBarbara JanssensJolanda van HengelFrans Van Roy

A1 Journal Article in NEUROMOLECULAR MEDICINE

2003

Assessment of the CTNNA3 gene encoding human alpha T-catenin regarding its involvement in dilated cardiomyopathy

Barbara JanssensSteven GoossensGriet VanpouckePatrick KoolsTony MontoyeJolanda van HengelFrans Van Roy

A1 Journal Article in HUMAN GENETICS

2001

alpha T-Catenin: a novel tissue-specific beta-catenin-binding protein mediating strong cell-cell adhesion.

Barbara JanssensSteven GoossensJolanda van HengelErik BruyneelMarcus MareelFrans Van Roy

A1 Journal Article in JOURNAL OF CELL SCIENCE