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Researcher
Steven Goossens
Profile
Projects
Publications
Activities
Awards & Distinctions
100
Results
2024
Dual targeting of MAPK and PI3K pathways unlocks redifferentiation of Braf-mutated thyroid cancer organoids
Helene Lasolle
Andrea Schiavo
Adrien Tourneur
Pierre Gillotay
Barbara de Faria da Fonseca
Lucieli Ceolin
Olivier Monestier
Benilda Aganahi
Laura Chomette
Marina Malta Letro Kizys
et al.
A1
Journal Article
in
ONCOGENE
2024
Functional evaluation of transcription factors in T-ALL : MYB and SOX11
André Pedro Pinto De Almeida
Pieter Van Vlierberghe
Steven Goossens
Tim Pieters
Tom Taghon
Dissertation
2024
Myb overexpression synergizes with the loss of Pten and is a dependency factor and therapeutic target in T-cell lymphoblastic leukemia
André Pedro Pinto De Almeida
Sara T'Sas
Luca Pagliaro
Igor Fijalkowski
Wouter Sleeckx
Hannah Van Steenberge
Raffaella Zamponi
Béatrice Lintermans
Wouter Van Loocke
Bruno Palhais
et al.
A1
Journal Article
in
HEMASPHERE
2024
PDXGhent : patient derived tumor xenografting mouse Core Facility Ghent
Liselot Mus
Steven Goossens
Tim Lammens
Lindsey Devisscher
Panagiotis Ntziachristos
Olivier De Wever
Frédéric Clement
C3
Conference
2024
PDXGhent : patient derived tumor xenografting mouse core facility Ghent
Liselot Mus
Steven Goossens
Tim Lammens
Lindsey Devisscher
Panagiotis Ntziachristos
Olivier De Wever
Frédéric Clement
C3
Conference
2024
Targeting hyperactive platelet-derived growth factor receptor-β signaling in T-cell acute lymphoblastic leukemia and lymphoma
Stien De Coninck
Renate De Smedt
Béatrice Lintermans
Lindy Reunes
Hansen J. Kosasih
Alexandra Reekmans
Lauren M. Brown
Nadine Van Roy
Bruno Palhais
Juliette Roels
et al.
A1
Journal Article
in
HAEMATOLOGICA
2024
Unravelling novel key players in T-cell acute lymphoblastic leukemia and lymphoma
Stien De Coninck
Pieter Van Vlierberghe
Steven Goossens
Tim Pieters
Dissertation
2024
2023
Epidrugs in cancer : epigenetic profiling to improve treamtent for T-cell lymphoblastic leukemia and lymphoma
Lien Provez
Pieter Van Vlierberghe
Steven Goossens
Maarten Dhaenens
Dissertation
2023
In vivo stabilization of a less toxic asparaginase variant leads to a durable antitumor response in acute leukemia
Maaike Van Trimpont
Amanda M. Schalk
Yanti De Visser
Hien Anh Nguyen
Lindy Reunes
Katrien Vandemeulebroecke
Evelien Peeters
Ying Su
Hyun Lee
Philip L. Lorenzi
et al.
A1
Journal Article
in
HAEMATOLOGICA
2023
Mutations in the histone methyltransferase Ezh2 drive context-dependent leukemia in Xenopus tropicalis
Dieter Tulkens
Marthe Boelens
Thomas Naert
Marjolein Carron
Suzan Demuynck
Sylviane Dewaele
Gert Van Isterdael
David Creytens
Tim Pieters
Steven Goossens
et al.
A1
Journal Article
in
LEUKEMIA
2023
The epithelial-mesenchymal plasticity landscape: principles of design and mechanisms of regulation
Jef Haerinck
Steven Goossens
Geert Berx
A1
Journal Article
in
NATURE REVIEWS GENETICS
2023
2022
Direct and indirect anti-leukemic properties of Activity-on-Target interferons for the treatment of T-cell acute lymphoblastic leukemia
Steven Goossens
Anje Cauwels
Tim Pieters
Renate De Smedt
Sara T'Sas
André Pedro Pinto De Almeida
Willem Daneels
Pieter Van Vlierberghe
Jan Tavernier
A1
Journal Article
in
HAEMATOLOGICA
2022
Distinct transcriptional programs in ascitic and solid cancer cells induce different responses to chemotherapy in high-grade serous ovarian cancer
Nele Loret
Niels Vandamme
Jordy De Coninck
Joachim Taminau
Kato De Clercq
Gillian Blancke
Sven Jonckheere
Steven Goossens
Kelly Lemeire
Sofie De Prijck
et al.
A1
Journal Article
in
MOLECULAR CANCER RESEARCH
2022
Epithelial-mesenchymal transition (EMT) as a therapeutic target
Sven Jonckheere
Jamie Adams
Dominic De Groote
Kyra Campbell
Geert Berx
Steven Goossens
A1
Journal Article
in
CELLS TISSUES ORGANS
2022
MEF2C opposes Notch in lymphoid lineage decision and drives leukemia in the thymus
Kirsten Canté-Barrett
Mariska T. Meijer
Valentina Cordo
Rico Hagelaar
Wentao Yang
Jiyang Yu
Willem K. Smits
Marloes E. Nulle
Joris P. Jansen
Rob Pieters
et al.
A1
Journal Article
in
JCI INSIGHT
2022
Myb drives B-cell neoplasms and myeloid malignancies in vivo
Tim Pieters
André Pedro Pinto De Almeida
Sara T'Sas
Kelly Lemeire
Tino Hochepied
Geert Berx
Alex Kentsis
Steven Goossens
Pieter Van Vlierberghe
A1
Journal Article
in
BLOOD ADVANCES
2022
Novel insights on the use of L-asparaginase as an efficient and safe anti-cancer therapy
Maaike Van Trimpont
Evelien Peeters
Yanti De Visser
Amanda M. Schalk
Veerle Mondelaers
Barbara De Moerloose
Arnon Lavie
Tim Lammens
Steven Goossens
Pieter Van Vlierberghe
A1
Journal Article
in
CANCERS
2022
Novel molecular insights and improved therapies in T-cell acute lymphoblastic leukemia
Maaike Van Trimpont
Pieter Van Vlierberghe
Steven Goossens
Dissertation
2022
RRM2 enhances MYCN-driven neuroblastoma formation and acts as a synergistic target with CHK1 inhibition
Carolina de Carvalho Nunes
Lisa Depestel
Liselot Mus
Kaylee M. Keller
Louis Delhaye
Amber Louwagie
Muhammad Rishfi
Alex Whale
Neesha Kara
Simon R. Andrews
et al.
A1
Journal Article
in
SCIENCE ADVANCES
2022
Therapeutic targeting of ZEB1-mediated EMT in metastatic colorectal cancer
Sven Jonckheere
Geert Berx
Steven Goossens
Dissertation
2022
2021
Cyclin D2 overexpression drives B1a-derived MCL-like lymphoma in mice
Tim Pieters
Sara T'Sas
Stijn Vanhee
André Pedro Pinto De Almeida
Yasmine Driege
Juliette Roels
Wouter Van Loocke
Willem Daneels
Mathijs Baens
Arnaud Marchand
et al.
A1
Journal Article
in
JOURNAL OF EXPERIMENTAL MEDICINE
2021
Interplay between the EMT transcription factors ZEB1 and ZEB2 regulates hematopoietic stem and progenitor cell differentiation and hematopoietic lineage fidelity
Jueqiong Wang
Carlos Farkas
Aissa Benyoucef
Catherine Carmichael
Katharina Haigh
Nick Wong
Danny Huylebroeck
Marc P. Stemmler
Simone Brabletz
Thomas Brabletz
et al.
A1
Journal Article
in
PLOS BIOLOGY
2021
Pancreas morphogenesis and homeostasis depends on tightly regulated Zeb1 levels in epithelial cells
Maria Lasierra Losada
Melissa Pauler
Niels Vandamme
Steven Goossens
Geert Berx
Moritz Leppkes
Harald Schuhwerk
Simone Brabletz
Thomas Brabletz
Marc P. Stemmler
A1
Journal Article
in
CELL DEATH DISCOVERY
2021
RUNX2 regulates leukemic cell metabolism and chemotaxis in high-risk T cell acute lymphoblastic leukemia
Filip Matthijssens
Nitesh D. Sharma
Monique Nysus
Christian K. Nickl
Huining Kang
Dominique R. Perez
Béatrice Lintermans
Wouter Van Loocke
Juliette Roels
Sofie Peirs
et al.
A1
Journal Article
in
JOURNAL OF CLINICAL INVESTIGATION
2021
SOX11 functions as an oncogene in Lmo2-driven T-cell lymphoblastic leukemia (T-ALL)
André Pedro Pinto De Almeida
Tim Pieters
Sara T'Sas
Steven Goossens
Pieter Van Vlierberghe
C3
Conference
2021
The spleen as a sanctuary site for residual leukemic cells following ABT-199 monotherapy in ETP-ALL
Alessandra Di Grande
Sofie Peirs
Paul D. Donovan
Maaike Van Trimpont
Julie Morscio
Béatrice Lintermans
Lindy Reunes
Niels Vandamme
Steven Goossens
Hien Anh Nguyen
et al.
A1
Journal Article
in
BLOOD ADVANCES
2021
Unlike its paralog LEDGF/p75, HRP-2 is dispensable for MLL-R leukemogenesis but important for leukemic cell survival
Siska Van Belle
Sara El Ashkar
Kateřina Čermáková
Filip Matthijssens
Steven Goossens
Alessandro Canella
Courtney H. Hodges
Frauke Christ
Jan De Rijck
Pieter Van Vlierberghe
et al.
A1
Journal Article
in
CELLS
2021
2020
Aging of preleukemic thymocytes drives CpG island hypermethylation in T-cell acute lymphoblastic leukemia
Juliette Roels
Morgan Thénoz
Bronislawa Szarzynska
Mattias Landfors
Stien De Coninck
Lisa Demoen
Lien Provez
Anna Kuchmiy
Steven Strubbe
Lindy Reunes
et al.
C3
Conference
2020
Aging of preleukemic thymocytes drives CpG island hypermethylation in T-cell acute lymphoblastic leukemia
Juliette Roels
Morgan Thénoz
B Szarzyńska
M Landfors
Stien De Coninck
Lisa Demoen
Lien Provez
Anna Kuchmiy
Steven Strubbe
Lindy Reunes
et al.
A2
Journal Article
in
BLOOD CANCER DISCOVERY
2020
Finding the 'key' in leukemia : PIM1 inhibition as a novel therapy in T-cell acute lymphoblastic leukemia
Renate De Smedt
Pieter Van Vlierberghe
Steven Goossens
Dissertation
2020
Publisher correction : Zeb2 drives invasive and microbiota-dependent colon carcinoma
Karolina Slowicka
Ioanna Petta
Gillian Blancke
Esther Hoste
Emilie Dumas
Mozes Sze
Hanna-Kaisa Vikkula
Enrico Radaelli
Jody J. Haigh
Sven Jonckheere
et al.
Correction
2020
Targeting cytokine- and therapy-induced PIM1 activation in preclinical models of T-cell acute lymphoblastic leukemia and lymphoma
Renate De Smedt
Julie Morscio
Lindy Reunes
Juliette Roels
Valentina Bardelli
Béatrice Lintermans
Wouter Van Loocke
Afonso Almeida
Laurence C. Cheung
Rishi S. Kotecha
et al.
A1
Journal Article
in
BLOOD
2020
Teaching an old dog new tricks : activity-on-target interferon to treat T-cell acute lymphoblastic leukemia
Steven Goossens
Anje Cauwels
Tim Pieters
Willem Daneels
Pieter Van Vlierberghe
Jan Tavernier
C3
Conference
2020
The EMT modulator SNAI1 contributes to AML pathogenesis via its interaction with LSD1
Catherine L. Carmichael
Jueqiong Wang
Thao Nguyen
Oluseyi Kolawole
Aissa Benyoucef
Charlotte De Mazière
Anna Milne
Sona Samuel
Kevin Robert Gillinder
Soroor Hediyeh-zadeh
et al.
A1
Journal Article
in
BLOOD
2020
The EMT transcription factor ZEB2 promotes proliferation of primary and metastatic melanoma while suppressing an invasive, mesenchymal-like phenotype
Niels Vandamme
Geertrui Denecker
Kenneth Bruneel
Gillian Blancke
Ozden Akay
Joachim Taminau
Jordy De Coninck
Eva De Smedt
Nicolas Skrypek
Wouter Van Loocke
et al.
A1
Journal Article
in
CANCER RESEARCH
2020
Zeb2 drives invasive and microbiota-dependent colon carcinoma
Karolina Slowicka
Ioanna Petta
Gillian Blancke
Esther Hoste
Emilie Dumas
Mozes Sze
Hanna-Kaisa Vikkula
Enrico Radaelli
Jody J. Haigh
Sven Jonckheere
et al.
A1
Journal Article
in
NATURE CANCER
2020
2019
Genetic characterization and therapeutic targeting of MYC-rearranged T cell acute lymphoblastic leukaemia
Gloria Milani
Filip Matthijssens
Wouter Van Loocke
Kaat Durinck
Juliette Roels
Sofie Peirs
Morgan Thénoz
Tim Pieters
Lindy Reunes
Béatrice Lintermans
et al.
A1
Journal Article
in
BRITISH JOURNAL OF HAEMATOLOGY
2019
Novel strategy for rapid functional in vivo validation of oncogenic drivers in haematological malignancies
Tim Pieters
Sara T'Sas
Lisa Demoen
André Pedro Pinto De Almeida
Lieven Haenebalcke
Filip Matthijssens
Kelly Lemeire
Jinke D'Hont
Frédérique Vanrockeghem
Tino Hochepied
et al.
A1
Journal Article
in
SCIENTIFIC REPORTS
2019
Targeting steroid resistance in T-cell acute lymphoblastic leukemia
Renate De Smedt
Julie Morscio
Steven Goossens
Pieter Van Vlierberghe
A1
Journal Article
in
BLOOD REVIEWS
2019
USP7 cooperates with NOTCH1 to drive the oncogenic transcriptional program in T-cell leukemia
Qi Jin
Carlos A Martinez
Kelly M Arcipowski
Yixing Zhu
Blanca T Gutierrez-Diaz
Kenneth K Wang
Megan R Johnson
Andrew G Volk
Feng Wang
Jian Wu
et al.
A1
Journal Article
in
CLINICAL CANCER RESEARCH
2019
ZEB2 and LMO2 drive immature T-cell lymphoblastic leukemia via distinct oncogenic mechanisms
Steven Goossens
Jueqiong Wang
Cedric Tremblay
Jelle De Medts
Sara T'Sas
Thao Nguyen
Jesslyn Saw
Katharina Haigh
David J Curtis
Pieter Van Vlierberghe
et al.
A1
Journal Article
in
HAEMATOLOGICA
2019
2018
A knock-in/knock-out mouse model of HSPB8-associated distal hereditary motor neuropathy and myopathy reveals toxic gain-of-function of mutant Hspb8
Delphine Bouhy
Manisha Juneja
Istvan Katona
Anne Holmgren
Bob Asselbergh
Vicky De Winter
Tino Hochepied
Steven Goossens
Jody J Haigh
Claude Libert
et al.
A1
Journal Article
in
ACTA NEUROPATHOLOGICA
2018
A novel L-asparaginase with low L-glutaminase coactivity is highly efficacious against both T- and B-cell acute lymphoblastic leukemias in vivo
Hien Anh Nguyen
Ying Su
Jenny Yu Zhang
Aleksandar Antanasijevic
Michael Caffrey
Amanda M Schalk
Li Liu
Damiano Rondelli
Annie Oh
Dolores L Mahmud
et al.
A1
Journal Article
in
CANCER RESEARCH
2018
Expressed repetitive elements are broadly applicable reference targets for normalization of reverse transcription-qPCR data in mice
Marjolijn Renard
Suzanne Vanhauwaert
Marine Vanhomwegen
Ali Rihani
Niels Vandamme
Steven Goossens
Geert Berx
Pieter Van Vlierberghe
Jody J Haigh
Bieke Decaesteker
et al.
A1
Journal Article
in
SCIENTIFIC REPORTS
2018
LEDGF/p75 is dispensable for hematopoiesis but essential for MLL-rearranged leukemogenesis
Sara El Ashkar
Juerg Schwaller
Tim Pieters
Steven Goossens
Jonas Demeulemeester
Frauke Christ
Siska Van Belle
Sabine Juge
Nancy Boeckx
Alan Engelman
et al.
A1
Journal Article
in
BLOOD
2018
Pre-clinical evaluation of second generation PIM inhibitors for the treatment of T-cell acute lymphoblastic leukemia and lymphoma
Renate De Smedt
Sofie Peirs
Julie Morscio
Filip Matthijssens
Juliette Roels
Lindy Reunes
Béatrice Lintermans
Steven Goossens
Tim Lammens
Nadine Van Roy
et al.
A1
Journal Article
in
HAEMATOLOGICA
2018
ZEB proteins in leukemia : friends, foes, or friendly foes?
Bieke Soen
Niels Vandamme
Geert Berx
Jürg Schwaller
Pieter Van Vlierberghe
Steven Goossens
A2
Journal Article
in
HEMASPHERE
2018
ZEB2 stably represses RAB25 expression through epigenetic regulation by SIRT1 and DNMTs during epithelial-to-mesenchymal transition
Nicolas Skrypek
Kenneth Bruneel
Cindy Vandewalle
Eva De Smedt
Bieke Soen
Nele Loret
Joachim Taminau
Steven Goossens
Niels Vandamme
Geert Berx
A1
Journal Article
in
EPIGENETICS & CHROMATIN
2018
2017
EMT transcription factors in cancer development re-evaluated : beyond EMT and MET
Steven Goossens
Niels Vandamme
Pieter Van Vlierberghe
Geert Berx
A1
Journal Article
in
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
2017
Epithelial-to-mesenchymal transition : epigenetic reprogramming driving cellular plasticity
Nicolas Skrypek
Steven Goossens
Eva De Smedt
Niels Vandamme
Geert Berx
A1
Journal Article
in
TRENDS IN GENETICS
2017
Novel oncogenic noncoding mutations in T-ALL
Steven Goossens
Pieter Van Vlierberghe
Editorial material
2017
Oncogenic ZEB2 activation drives sensitivity toward KDM1A inhibition in T-cell acute lymphoblastic leukemia
Steven Goossens
Sofie Peirs
Wouter Van Loocke
Jueqiong Wang
Mina Takawy
Filip Matthijssens
Stefan E Sonderegger
Katharina Haigh
Thao Nguyen
Niels Vandamme
et al.
A1
Journal Article
in
BLOOD
2017
Structure-function studies in mouse embryonic stem cells using recombinase-mediated cassette exchange
Tim Pieters
Lieven Haenebalcke
Kenneth Bruneel
Niels Vandamme
Tino Hochepied
Jolanda van Hengel
Dagmar Wirth
Geert Berx
Jody J Haigh
Frans Van Roy
et al.
A1
Journal Article
in
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
2017
Targeting BET proteins improves the therapeutic efficacy of BCL-2 inhibition in T-cell acute lymphoblastic leukemia
Sofie Peirs
V Frismantas
Filip Matthijssens
W Van Loocke
Tim Pieters
Niels Vandamme
Béatrice Lintermans
MP Dobay
Geert Berx
Bruce Poppe
et al.
A1
Journal Article
in
LEUKEMIA
2017
The EMT transcription factor Zeb2 controls adult murine hematopoietic differentiation by regulating cytokine signaling
Jin Li
Tamara Riedt
Steven Goossens
Carmen Carrillo Garcia
Sabrina Szczepanski
Maria Brandes
Tim Pieters
Linne Dobrosch
Ines Guetgemann
Natalie Farla
et al.
A1
Journal Article
in
BLOOD
2017
Zeb2 regulates cell fate at the exit from epiblast state in mouse embryonic stem cells
Agata Stryjewska
Ruben Dries
Tim Pieters
Griet Verstappen
Andrea Conidi
Kathleen Coddens
Annick Francis
Lieve Umans
Wilfred FJ van IJcken
Geert Berx
et al.
A1
Journal Article
in
STEM CELLS
2017
2016
Characterization of new transgenic mouse models for two Charcot-Marie-tooth-causing HspB1 mutations using the Rosa26 locus
Delphine Bouhy
Thomas Geuens
Vicky De Winter
Leonardo De Almeida Souza
Istvan Katona
Joachim Weis
Tino Hochepied
Steven Goossens
Jody Haigh
Sophie Janssens
et al.
A2
Journal Article
in
JOURNAL OF NEUROMUSCULAR DISEASES
2016
Cyclin D2 overexpression recapitulates mantle cell lymphoma in mice
Tim Pieters
Steven Goossens
Sara T'Sas
Geert Berx
Jody J Haigh
Pieter Van Vlierberghe
C3
Conference
2016
Fast generation of conditional ROSA26-based mouse models that recapitulate genomic events in human T-ALL
Tim Pieters
Steven Goossens
Sara T'Sas
Lieven Haenebalcke
Tino Hochepied
Béatrice Lintermans
Sofie Peirs
Filip Matthijssens
J Haigh
Geert Berx
et al.
C3
Conference
2016
LIN28B is over-expressed in specific subtypes of pediatric leukemia and regulates lncRNA H19
Hetty Helsmoortel
Barbara De Moerloose
Tim Pieters
Farzaneh Ghazavi
Silvia Bresolin
Helene Cave
Andrica de Vries
Valerie de Haas
Christian Flotho
Veerle Labarque
et al.
A1
Journal Article
in
HAEMATOLOGICA
2016
Oncogenic ZEB2 activation drives sensitivity towards LSD1 inhibition in T-Cell acute lymphoblastic leukemia
Steven Goossens
Sofie Peirs
Geert Berx
Pieter Van Vlierberghe
Jody J Haigh
C3
Conference
2016
Overcoming steroid resistance in T cell acute lymphoblastic leukemia
Steven Goossens
Pieter Van Vlierberghe
Editorial material
2016
p120 Catenin-mediated stabilization of E-cadherin is essential for primitive endoderm specification
Tim Pieters
Steven Goossens
Lieven Haenebalcke
Vanessa Andries
Agata Stryjewska
Riet De Rycke
Kelly Lemeire
Tino Hochepied
Danny Huylebroeck
Geert Berx
et al.
A1
Journal Article
in
PLOS GENETICS
2016
2015
Alpha-catenins control cardiomyocyte proliferation by regulating Yap activity
Jifen Li
Erhe Gao
Alexia Vite
Roslyn Yi
Ludovic Gomez
Steven Goossens
Frans Van Roy
Glenn L Radice
A1
Journal Article
in
CIRCULATION RESEARCH
2015
Immunohistological description of nongestational ovarian choriocarcinoma in two female mice with conditional loss of Trp53 driven by the Tie2 promoter
V Castiglioni
Morvarid Farhang Ghahremani
Steven Goossens
M De Maglie
M Ardizzone
Jody Haigh
E Radaelli
A1
Journal Article
in
VETERINARY PATHOLOGY
2015
MicroRNA-193b-3p acts as a tumor suppressor by targeting the MYB oncogene in T-cell acute lymphoblastic leukemia
Evelien Mets
Joni Van der Meulen
Gert Van Peer
Michael Boice
Pieter Mestdagh
Inge Van de Walle
Tim Lammens
Steven Goossens
Barbara De Moerloose
Yves Benoit
et al.
A1
Journal Article
in
LEUKEMIA
2015
Novel biological insights in T-cell acute lymphoblastic leukemia
Kaat Durinck
Steven Goossens
Sofie Peirs
Annelynn Wallaert
Wouter Van Loocke
Filip Matthijssens
Tim Pieters
Gloria Milani
Tim Lammens
Pieter Rondou
et al.
A1
Journal Article
in
EXPERIMENTAL HEMATOLOGY
2015
Strategies to rescue the consequences of inducible arginase-1 deficiency in mice
Laurel L Ballantyne
Yuan Yan Sin
Tim St Amand
Joshua Si
Steven Goossens
Lieven Haenebalcke
Jody Haigh
Lianna Kyriakopoulou
Andrea Schulze
Colin D Funk
A1
Journal Article
in
PLOS ONE
2015
Terminal NK cell maturation is controlled by concerted actions of T-bet and Zeb2 and is essential for melanoma rejection
Mary van Helden
Steven Goossens
Cécile Daussy
Anne-Laure Mathieu
Fabrice Faure
Antoine Marçais
Niels Vandamme
Natalie Farla
Katia Mayol
Sébastien Viel
et al.
A1
Journal Article
in
JOURNAL OF EXPERIMENTAL MEDICINE
2015
Transcriptional repressor ZEB2 promotes terminal differentiation of CD8⁺ effector and memory T cell populations during infection
Kyla D Omilusik
J Adam Best
Bingfei Yu
Steven Goossens
Alexander Weidemann
Jessica V Nguyen
Eve Seuntjens
Agata Stryjewska
Christiane Zweier
Rahul Roychoudhuri
et al.
A1
Journal Article
in
JOURNAL OF EXPERIMENTAL MEDICINE
2015
ZEB2 drives immature T-cell lymphoblastic leukaemia development via enhanced tumour-initiating potential and IL-7 receptor signalling
Steven Goossens
Enrico Radaelli
Odile Blanchet
Kaat Durinck
Joni Van der Meulen
Sofie Peirs
Tom Taghon
Cedric S Tremblay
Magdaline Costa
Morvarid Farhang Ghahremani
et al.
A1
Journal Article
in
NATURE COMMUNICATIONS
2015
2014
ABT-199 mediated inhibition of BCL-2 as a novel therapeutic strategy in T-cell acute lymphoblastic leukemia
Sofie Peirs
Filip Matthijssens
Steven Goossens
Inge Van de Walle
Katia Ruggero
Charles E de Bock
Sandrine Degryse
Kirsten Canté-Barrett
Delphine Briot
Emmanuelle Clappier
et al.
A1
Journal Article
in
BLOOD
2014
ABT-199 mediated inhibition of BCL-2 as a novel therapeutic strategy in early immature T-cell acute lymphoblastic leukemia
Sofie Peirs
Filip Matthijssens
Steven Goossens
Kirsten Canté-Barrett
Tim Lammens
Barbara De Moerloose
Yves Benoit
Jean Soulier
Bruce Poppe
Tom Taghon
et al.
C3
Conference
2014
Controlling pre-leukemic thymocyte self-renewal
Steven Goossens
Pieter Van Vlierberghe
Editorial material
2014
Loss of autocrine endothelial-derived VEGF significantly reduces hemangiosarcoma development in conditional p53-deficient mice
Morvarid Farhang Ghahremani
Enrico Radaelli
Katharina Haigh
Sona Bartunkova
Lieven Haenebalcke
Jean-Christophe Marine
Steven Goossens
Jody Haigh
A1
Journal Article
in
CELL CYCLE
2014
MicroRNA-128-3p is a novel oncomiR targeting PHF6 in T-cell acute lymphoblastic leukemia
Evelien Mets
Gert Van Peer
Joni Van der Meulen
Michael Boice
Tom Taghon
Steven Goossens
Pieter Mestdagh
Yves Benoit
Barbara De Moerloose
Nadine Van Roy
et al.
A1
Journal Article
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HAEMATOLOGICA
2014
ZEB2-transgene expression in the epidermis compromises the integrity of the epidermal barrier through the repression of different tight junction proteins
Marianthi Tatari
Bram De Craene
Bieke Soen
Joachim Taminau
Petra Vermassen
Steven Goossens
Katharina Haigh
Silvia Cazzola
Jo Lambert
Danny Huylebroeck
et al.
A1
Journal Article
in
CELLULAR AND MOLECULAR LIFE SCIENCES
2014
2013
Beta-actin is involved in modulating erythropoiesis during development by fine-tuning Gata2 expression levels
Davina Tondeleir
Benjamin Drogat
Karolina Slowicka
Karima Bakkali
Sona Bartunkova
Steven Goossens
Jody Haigh
Christophe Ampe
A1
Journal Article
in
PLOS ONE
2013
Directed migration of cortical interneurons depends on the cell-autonomous action of Sip1
Veronique van den Berghe
Elke Stappers
Bram Vandesande
Jordane Dimidschstein
Roel Kroes
Annick Francis
Andrea Conidi
Flore Lesage
Ruben Dries
Silvia Cazzola
et al.
A1
Journal Article
in
NEURON
2013
Efficient ROSA26-based conditional and/or inducible transgenesis using RMCE-compatible F1 hybrid mouse embryonic stem cells
Lieven Haenebalcke
Steven Goossens
Michaël Naessens
Natascha Kruse
Morvarid Farhang Ghahremani
Sona Bartunkova
Katharina Haigh
Tim Pieters
Pieterjan Dierickx
Benjamin Drogat
et al.
A1
Journal Article
in
STEM CELL REVIEWS AND REPORTS
2013
The ROSA26-iPSC mouse : a conditional, inducible, and exchangeable resource for studying cellular (de)differentiation
Lieven Haenebalcke
Steven Goossens
Pieterjan Dierickx
Sona Bartunkova
Jinke D'Hont
Katharina Haigh
Tino Hochepied
Dagmar Wirth
Andras Nagy
Jody Haigh
A1
Journal Article
in
CELL REPORTS
2013
The p53 family and VEGF regulation: 'It's complicated'
Morvarid Farhang Ghahremani
Steven Goossens
Jody Haigh
Editorial material
2013
p53 promotes VEGF expression and angiogenesis in the absence of an intact p21-Rb pathway
Morvarid Farhang Ghahremani
Steven Goossens
D Nittner
X Bisteau
Sona Bartunkova
A Zwolinska
Paco Hulpiau
Katharina Haigh
Lieven Haenebalcke
Benjamin Drogat
et al.
A1
Journal Article
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CELL DEATH AND DIFFERENTIATION
2013
2012
Loss of αT-catenin alters the hybrid adhering junctions in the heart and leads to dilated cardiomyopathy and ventricular arrhythmia following acute ischemia
Jifen Li
Steven Goossens
Jolanda van Hengel
Erhe Gao
Lan Cheng
Koen Tyberghein
Xiying Shang
Riet De Rycke
Frans Van Roy
Glenn L Radice
A1
Journal Article
in
JOURNAL OF CELL SCIENCE
2012
The role of EMT modulators in hematopoiesis and leukemic transformation
Steven Goossens
Jody Haigh
Bookchapter
in
Hematology : science and practice
2012
Tissue-wide overexpression of alpha-T-catenin results in aberrant trophoblast invasion but does not cause embryonic mortality in mice
Koen Tyberghein
Steven Goossens
Jody Haigh
Frans Van Roy
Jolanda van Hengel
A1
Journal Article
in
PLACENTA
2012
2011
A vascular niche and a VEGF-Nrp1 loop regulate the initiation and stemness of skin tumours
Benjamin Beck
Gregory Driessens
Steven Goossens
Khalil Kass Youssef
Anna Kuchnio
Amélie Caauwe
Panagiota A Sotiropoulou
Sonja Loges
Gaelle Lapouge
Aurélie Candi
et al.
A1
Journal Article
in
NATURE
2011
The EMT regulator Zeb2/Sip1 is essential for murine embryonic hematopoietic stem/progenitor cell differentiation and mobilization
Steven Goossens
Viktor Janzen
Sona Bartunkova
Tomomasa Yokomizo
Benjamin Drogat
Mihaela Crisan
Katharina Haigh
Eve Seuntjens
Lieve Umans
Tamara Riedt
et al.
A1
Journal Article
in
BLOOD
2011
2010
Increased skeletal VEGF enhances β-catenin activity and results in excessively ossified bones
Christa Maes
Steven Goossens
Sona Bartunkova
Benjamin Drogat
Lieven Coenegrachts
Ingrid Stockmans
Karen Moermans
Omar Nyabi
Katharina Haigh
Michaël Naessens
et al.
A1
Journal Article
in
EMBO JOURNAL
2010
Vegf regulates embryonic erythroid development through Gata1 modulation
Benjamin Drogat
Joanna Kalucka
Laura Gutierrez
Hamida Hammad
Steven Goossens
Morvarid Farhang Ghahremani
Sona Bartunkova
Katharina Haigh
Kim Deswarte
Omar Nyabi
et al.
A1
Journal Article
in
BLOOD
2010
2009
Efficient mouse transgenesis using Gateway-compatible ROSA26 locus targeting vectors and F1 hybrid ES cells
Omar Nyabi
Michaël Naessens
Katharina Haigh
Agnieszka Gembarska
Steven Goossens
Marion Maetens
Sarah De Clercq
Benjamin Drogat
Lieven Haenebalcke
Sona Bartunkova
et al.
A1
Journal Article
in
NUCLEIC ACIDS RESEARCH
2009
2008
Plakophilin-3-deficient mice develop hair coat abnormalities and are prone to cutaneous inflammation
Tatyana Sklyarova
Stefan Bonné
Petra D'Hooge
Geertrui Denecker
Steven Goossens
Riet De Rycke
Gaetan Borgonie
Michael Bösl
Frans Van Roy
Jolanda van Hengel
A1
Journal Article
in
JOURNAL OF INVESTIGATIVE DERMATOLOGY
2008
2007
A unique and specific interaction between alpha T-catenin and plakophilin-2 in the area composita, the mixed-type junctional structure of cardiac intercalated discs
Steven Goossens
Barbara Janssens
Stefan Bonné
Riet De Rycke
Filip Braet
Jolanda van Hengel
Frans Van Roy
A1
Journal Article
in
JOURNAL OF CELL SCIENCE
2007
Alpha-T-catenin (CTNNA3) displays turnour specific monoallelic expression in urothelial carcinoma of the bladder
M MEEHAN
A MELVIN
E GALLAGHER
J SMITH
A MC GOLDRICK
C MOSS
Steven Goossens
M HARRISON
E KAY
J FITZPATRICK
et al.
A1
Journal Article
in
GENES CHROMOSOMES & CANCER
2007
Truncated isoform of mouse alpha T-catenin is testis-restricted in expression and function
Steven Goossens
Barbara Janssens
Griet Vanpoucke
Riet De Rycke
J VAN HENGEL
Frans Van Roy
A1
Journal Article
in
FASEB JOURNAL
2007
2005
Cadherin-mediated cell-cell adhesion in the testis
Steven Goossens
Frans Van Roy
A1
Journal Article
in
FRONTIERS IN BIOSCIENCE
2005
2004
GATA-4 and MEF2C transcription factors control the tissue-specific expression of the αT-catenin gene CTNNA3
Griet Vanpoucke
Steven Goossens
Bram De Craene
Barbara Gilbert
Frans Van Roy
Geert Berx
A1
Journal Article
in
NUCLEIC ACIDS RESEARCH
2004
alpha-T-catenin is expressed in human brain and interacts with the Wnt signaling pathway but is not responsible for linkage to chromosome 10 in Alzheimer's disease
V BUSBY
Steven Goossens
P NOWOTNY
G HAMILTON
S SMEMO
D HAROLD
D TURIC
L JEHU
A MYERS
M WOMICK
et al.
A1
Journal Article
in
NEUROMOLECULAR MEDICINE
2004
2003
Assessment of the CTNNA3 gene encoding human alpha T-catenin regarding its involvement in dilated cardiomyopathy
Barbara Janssens
B MOHAPATRA
M VATTA
Steven Goossens
Griet Vanpoucke
Patrick Kools
Tony Montoye
Jolanda van Hengel
NE BOWLES
Frans Van Roy
et al.
A1
Journal Article
in
HUMAN GENETICS
2003
2001
alpha T-Catenin: a novel tissue-specific beta-catenin-binding protein mediating strong cell-cell adhesion.
Barbara Janssens
Steven Goossens
K STAES
B GILBERT
Jolanda van Hengel
C COLPAERT
Erik Bruyneel
Marcus Mareel
Frans Van Roy
A1
Journal Article
in
JOURNAL OF CELL SCIENCE
2001