Research Explorer

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Researcher

Steven De Munck

Awards & Distinctions

13 Results

2025

Reanalysis of cryo-EM data reveals ALK-cytokine assemblies with both 2:1 and 2:2 stoichiometries

Jan FélixSteven De MunckJ. Fernando BazanSavvas Savvides

U Journal Article in PLOS BIOLOGY

2023

Improving de novo protein binder design with deep learning

Nathaniel R. BennettBrian CoventryInna GoreshnikBuwei HuangAza AllenDionne VafeadosYing Po PengJustas DauparasMinkyung BaekLance Stewart et al.

A1 Journal Article in NATURE COMMUNICATIONS

2021

Distinct EH domains of the endocytic TPLATE complex confer lipid and protein binding

Klaas YpermanAnna PapageorgiouRomain MerceronSteven De MunckYehudi BlochDominique EeckhoutQihang JiangPieter TackRosa GrigoryanThomas Evangelidis et al.

A1 Journal Article in NATURE COMMUNICATIONS

Structural basis of cytokine-mediated activation of ALK family receptors

Steven De MunckMathias ProvostMichiko KurikawaIkuko OmoriJunko MukohyamaJan FélixYehudi BlochOmar Abdel-WahabJ. Fernando BazanAkihide Yoshimi et al.

A1 Journal Article in NATURE

Structure and mechanism of cytokine mediated activation of ALK family receptor tyrosine kinases

Steven De MunckSavvas Savvides

2020

Endeavors towards transformation of M. tuberculosis thymidylate kinase (MtbTMPK) inhibitors into potential antimycobacterial agents

Yanlin JianRomain MerceronSteven De MunckHe Eun ForbesFabian HulpiaMartijn RisseeuwKristof Van HeckeSavvas SavvidesHélène Munier-LehmannHelena I. M. Boshoff et al.

A1 Journal Article in EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Homogeneously N-glycosylated proteins derived from the GlycoDelete HEK293 cell line enable diffraction-quality crystallogenesis

Sandra KozakYehudi BlochSteven De MunckAleksandra MikulaIsabel BentoSavvas SavvidesRob Meijers

A1 Journal Article in ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY

Structure and assembly mechanism of the signaling complex mediated by human CSF-1 (vol 23, pg 1621, 2015)

Jan FélixSteven De MunckKenneth VerstraeteLeander MeurisNico CallewaertJonathan ElegheertSavvas Savvides

2019

Activating mutations in CSF1R and additional receptor tyrosine kinases in histiocytic neoplasms

Benjamin H DurhamEstibaliz Lopez RodrigoJennifer PicarsicDavid AbramsonVeronica RotembergSteven De MunckErwin PannecouckeSydney X LuAlessandro PastoreAkihide Yoshimi et al.

A1 Journal Article in NATURE MEDICINE

Disruption of endocytosis through chemical inhibition of clathrin heavy chain function

Wim DejongheIsha SharmaBram DenooSteven De MunckQing LuKiril MishevHaydar BulutEvelien MylleRiet De RyckeMina Vasileva et al.

A1 Journal Article in NATURE CHEMICAL BIOLOGY

2018

Nonselective chemical inhibition of Sec7 domain-containing ARF GTPase exchange factors

Kiril MishevQing LuBram DenooFrancois PeuroisWim DejongheJan HullaertRiet De RyckeSjef BoerenMarine BretouSteven De Munck et al.

A1 Journal Article in PLANT CELL

2016

Structural basis of GM-CSF and IL-2 sequestration by the viral decoy receptor GIF

Jan FélixEaazhisai KandiahSteven De MunckYehudi BlochGydo CP van ZundertKris PauwelsAnn DansercoerKatka NovanskaRandy J ReadAlexandre MJJ Bonvin et al.

A1 Journal Article in NATURE COMMUNICATIONS

2015

Structure and assembly mechanism of the signaling complex mediated by human CSF-1

Jan FélixSteven De MunckKenneth VerstraeteLeander MeurisNico CallewaertJonathan ElegheertSavvas Savvides

A1 Journal Article in STRUCTURE