Research Explorer

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Researcher

Stephan Stremersch

Publications & Research Data

Awards & Distinctions

27 Results

2025

Pre-formation loading of extracellular vesicles with exogenous molecules using photoporation

Jana RamonCláudio PinheiroCharysse VandendriesscheEstefanía Lozano-AndrésHerlinde De KeersmaeckerDeep PunjJuan FraireEdward GeeurickxMarca H. M. WaubenPieter Vader et al.

A1 Journal Article in JOURNAL OF NANOBIOTECHNOLOGY

2022

Plasma membrane perforation by GSDME during apoptosis-driven secondary necrosis

Elke De SchutterJana RamonBenjamin PfeutyCaroline De TenderStephan StremerschKoen RaemdonckKen Op de BeeckWim DeclercqFranck RiquetKevin Braeckmans et al.

A1 Journal Article in CELLULAR AND MOLECULAR LIFE SCIENCES

Transient nuclear lamin A/C accretion aids in recovery from vapor nanobubble-induced permeabilisation of the plasma membrane

Gaëlle HouthaeveGerardo García-Díaz BarrigaStephan StremerschHerlinde De KeersmaeckerJuan FraireJo VandesompelePieter MestdaghStefaan De SmedtKevin BraeckmansWinnok De Vos

A1 Journal Article in CELLULAR AND MOLECULAR LIFE SCIENCES

2021

Bubble forming films for spatial selective cell killing

Dawei HuaAranit HarizajMike WelsToon BransStephan StremerschHerlinde De KeersmaeckerEduardo Bolea FernandezFrank VanhaeckeDimitri RoelsKevin Braeckmans et al.

A1 Journal Article in ADVANCED MATERIALS

Cas9 RNP transfection by vapor nanobubble photoporation for ex vivo cell engineering

Laurens RaesMelissa PilleAranit HarizajGlenn GoetgelukJelter Van HoeckStephan StremerschJuan FraireToon BransOlivier Gerrit de JongRoel Maas-Bakker et al.

A1 Journal Article in MOLECULAR THERAPY-NUCLEIC ACIDS

Cytosolic delivery of gadolinium via photoporation enables improved in vivo magnetic resonance imaging of cancer cells

Aranit HarizajBenedicte DescampsChristophe MangodtStephan StremerschArianna StoppaLieve BalcaenToon BransHilde De RoosterNausikaa DevriendtJuan Fraire et al.

A1 Journal Article in BIOMATERIALS SCIENCE

Nanoparticle-sensitized photoporation enables inflammasome activation studies in targeted single cells dagger

Aranit HarizajFilip Van HauwermeirenStephan StremerschRiet De RyckeHerlinde De KeersmaeckerToon BransJuan FraireKarolien GrauwenStefaan De SmedtIne Lentacker et al.

A1 Journal Article in NANOSCALE

Photoporation with biodegradable polydopamine nanosensitizers enables safe and efficient delivery of mRNA in human T cells

Aranit HarizajMike WelsLaurens RaesStephan StremerschGlenn GoetgelukToon BransBart VandekerckhoveFélix SauvageStefaan De SmedtIne Lentacker et al.

A1 Journal Article in ADVANCED FUNCTIONAL MATERIALS

2020

Intracellular delivery of mRNA in adherent and suspension cells by vapor nanobubble photoporation

Laurens RaesStephan StremerschJuan FraireToon BransGlenn GoetgelukStijn De MunterLien Van HoeckeRein VerbekeJelter Van HoeckRanhua Xiong et al.

A1 Journal Article in NANO-MICRO LETTERS

Vapor nanobubble is the more reliable photothermal mechanism for inducing endosomal escape of siRNA without disturbing cell homeostasis

Juan FraireGaëlle HouthaeveJing LiuLaurens RaesLotte VermeulenStephan StremerschToon BransGerardo Garcia-Diaz BarrigaSarah De KeulenaerFilip Van Nieuwerburgh et al.

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

2019

Delivery of mixed-lineage kinase domain-like protein by vapor nanobubble photoporation induces necroptotic-like cell death in tumor cells

Lien Van HoeckeLaurens RaesStephan StremerschToon BransJuan FraireRia RoelandtWim DeclercqPeter VandenabeeleKoen RaemdonckKevin Braeckmans et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Gold nanoparticle-mediated photoporation enables delivery of macromolecules over a wide range of molecular weights in human CD4+ T cells

Laurens RaesClarissa Van HeckeJulie MichielsStephan StremerschJuan FraireToon BransRanhua XiongStefaan De SmedtLinos VandekerckhoveKoen Raemdonck et al.

A1 Journal Article in CRYSTALS

Improved label-free identification of individual exosome-like vesicles with Au@Ag nanoparticles as SERS substrate

Juan FraireStephan StremerschDavinia BouckaertTinne MonteyneThomas De BeerPieter WuytensRiet De RyckeAndre SkirtachKoen RaemdonckStefaan De Smedt et al.

A1 Journal Article in ACS APPLIED MATERIALS & INTERFACES

2018

Nucleic acid loading and fluorescent labeling of isolated extracellular vesicles requires adequate purification

Stephan StremerschToon BransKevin BraeckmansStefaan De SmedtKoen Raemdonck

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Targeted perturbation of nuclear envelope integrity with vapor nanobubble-mediated photoporation

Gaëlle HouthaeveRanhua XiongJoke RobijnsBert LuyckxYasmine BeulqueToon BransCoen CampsteijnSangram Keshari SamalStephan StremerschStefaan De Smedt et al.

A1 Journal Article in ACS NANO

2017

Membrane vesicle secretion and prophage induction in multidrug-resistant Stenotrophomonas maltophilia in response to ciprofloxacin stress

Simon DevosWouter Van PutteJolien VitseGonzalez Van DriesscheStephan StremerschWim Van Den BroeckKoen RaemdonckKevin BraeckmansHenning StahlbergMisha Kudryashev et al.

A1 Journal Article in ENVIRONMENTAL MICROBIOLOGY

2016

Comparing exosome-like vesicles with liposomes for the functional cellular delivery of small RNAs

Stephan StremerschRoosmarijn VandenbrouckeElien Van WonterghemAn HendrixStefaan De SmedtKoen Raemdonck

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

Exploring extracellular vesicles for siRNA delivery and Raman-based diagnostics

Stephan StremerschStefaan De SmedtKoen RaemdonckKevin Braeckmans

Identification of a novel mechanism of blood-brain communication during peripheral inflammation via choroid plexus-derived extracellular vesicles

Sriram BalusuElien Van WonterghemRiet De RyckeKoen RaemdonckStephan StremerschKris GevaertMarjana BrkićDelphine DemeestereValerie VanhoorenAn Hendrix et al.

A1 Journal Article in EMBO MOLECULAR MEDICINE

Identification of individual exosome-like vesicles by surface enhanced Raman spectroscopy

Stephan StremerschMonica MarroBat-El PinchasikPieter BaatsenAn HendrixStefaan De SmedtPablo Loza-AlvarezAndre SkirtachKoen RaemdonckKevin Braeckmans

A1 Journal Article in SMALL

Intra- and interspecies effects of outer membrane vesicles from Stenotrophomonas maltophilia on β-lactam resistance

Simon DevosStephan StremerschKoen RaemdonckKevin BraeckmansBart Devreese

A1 Journal Article in ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Therapeutic and diagnostic applications of extracellular vesicles

Stephan StremerschStefaan De SmedtKoen Raemdonck

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

2015

Effect of native gastric mucus on in vivo hybridization therapies directed at Helicobacter pylori

Rita SantosGeorge DakwarRanhua XiongKatrien ForierKatrien RemautStephan StremerschNuno GuimarãesSilvia FonteneteJesper WengelMarina Leite et al.

A1 Journal Article in MOLECULAR THERAPY-NUCLEIC ACIDS

The effect of imipenem and diffusible signaling factors on the secretion of outer membrane vesicles and associated Ax21 proteins in Stenotrophomonas maltophilia

Simon DevosLaurence Van OudenhoveStephan StremerschWouter Van PutteRiet De RyckeGonzalez Van DriesscheJolien VitseKoen RaemdonckBart Devreese

A1 Journal Article in FRONTIERS IN MICROBIOLOGY

2014

On-chip light sheet illumination enables diagnostic size and concentration measurements of membrane vesicles in biofluids

Hendrik DeschoutKoen RaemdonckStephan StremerschPietro MaoddiGuillaume MernierPhilippe RenaudSebastien JiguetAn Hendrixmarc brackeRudy Van den Broecke et al.

A1 Journal Article in NANOSCALE

2013

Coupling of drug containing liposomes to microbubbles improves ultrasound triggered drug delivery in mice

Steven CoolBart GeersStefan RoelsStephan StremerschKatrien VanderperrenJimmy SaundersStefaan De SmedtJo DemeesterNiek Sanders

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

Electroporation-induced siRNA precipitation obscures the efficiency of siRNA loading into extracellular vesicles

Sander AA KooijmansStephan StremerschKevin BraeckmansStefaan De SmedtAn HendrixMatthew JA WoodRaymond M SchiffelersKoen RaemdonckPieter Vader

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE