Research Explorer

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Researcher

Stefan Magez

142 Results

2023

From helping to regulating : a transcriptomic profile of Ifng+ Il10+ Il21+ Cd4+ Th1 cells indicates their role in regulating inflammation during experimental trypanosomosis

Thi Thu Hang NguyenStefan MagezMagdalena Radwanska

A2 Journal Article in FRONTIERS IN TROPICAL DISEASES

Mosaic RBD nanoparticles induce intergenus cross-reactive antibodies and protect against SARS-CoV-2 challenge

Dan Bi LeeHyojin KimJu Hwan JeongUi Soon JangYuyeon JangSeokbeom RohHyunbum JeonEun Jeong KimSu Yeon HanJin Young Maeng et al.

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nanobody technology and new molecular biology methods to advance rapid diagnostic test for neglected tropical diseases

Andrés Álvarez RodríguezMagdalena RadwanskaStefan MagezSteven Odongo

Bookchapter in Rapid antigen testing

The pathogenesis of African trypanosomiasis

Etienne PaysMagdalena RadwanskaStefan Magez

A1 Journal Article in ANNUAL REVIEW OF PATHOLOGY-MECHANISMS OF DISEASE

2022

African trypanosomiasis

Stefan MagezThi Thu Hang NguyenJoar Esteban Pinto TorresMagdalena Radwanska

Bookchapter in Textbook of parasitic zoonoses

Assessing impacts of experimental trypanosome infections on B cell memory

Moon SangphilMagdalena RadwanskaStefan Magez

BCG-mediated protection against M. tuberculosis is sustained post-malaria infection independent of parasite virulence

Emily TangieAvril WaltersNai‐jen HsuMichelle FisherStefan MagezMuazzam JacobsRoanne Keeton

A1 Journal Article in IMMUNOLOGY

Detrimental effect of Trypanosoma brucei brucei infection on memory B cells and host ability to recall protective B-cell responses

Sangphil MoonIbo JanssensKyung Hyun KimBenoit StijlemansStefan MagezMagdalena Radwanska

A1 Journal Article in JOURNAL OF INFECTIOUS DISEASES

Recent progress in diagnosis and treatment of Human African Trypanosomiasis has made the elimination of this disease a realistic target by 2030

Andrés Álvarez RodríguezBo-kyung JinMagdalena RadwanskaStefan Magez

A1 Journal Article in FRONTIERS IN MEDICINE

Retrospective in silico mutation profiling of SARS-CoV-2 structural proteins circulating in Uganda by July 2021 : towards refinement of COVID-19 disease vaccines, diagnostics, and therapeutics

Steven OdongoHedmon OkellaChristian NdekeziMoses OkeeMonica NamayanjaBrian MujuniYann G. J. SterckxDennison KizitoMagdalena RadwanskaStefan Magez et al.

A1 Journal Article in PLOS ONE

The role of MIF and IL-10 as molecular Yin-Yang in the modulation of the host immune microenvironment during infections : African trypanosome infections as a paradigm

Benoit StijlemansMaxime SchoovaertsPatrick De BaetselierStefan MagezCarl De Trez

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Tipping the balance between erythroid cell differentiation and induction of anemia in response to the inflammatory pathology associated with chronic trypanosome infections

Thi Thu Hang NguyenMagdalena RadwanskaStefan Magez

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

2021

African trypanosomosis obliterates DTPa vaccine-induced functional memory so that post-treatment Bordetella pertussis challenge fails to trigger a protective recall response

Magdalena RadwanskaThi Thu Hang NguyenStefan Magez

A1 Journal Article in VACCINES

Automatic detection of Trypanosomosis in thick blood smears using image pre-processing and deep learning

Taewoo JungEsla Timothy AnzakuUtku ÖzbulakStefan MagezArnout Van MessemWesley De Neve

Comprehensive genomic analysis reveals virulence factors and antibiotic resistance genes in Pantoea agglomerans KM1, a potential opportunistic pathogen

Robin GuevarraStefan MagezEveline PeetersMi Sook ChungKyung Hyun KimMagdalena Radwanska

A1 Journal Article in PLOS ONE

Improving the yield of recalcitrant Nanobodies® by simple modifications to the standard protocol

Christopher K. KariukiStefan Magez

A1 Journal Article in PROTEIN EXPRESSION AND PURIFICATION

Salivarian trypanosomes have adopted intricate host-pathogen interaction mechanisms that ensure survival in plain sight of the adaptive immune system

Stefan MagezJoar Esteban Pinto TorresSeoyeon OhMagdalena Radwanska

A1 Journal Article in PATHOGENS

Single-cell transcriptome profiling and the use of AID deficient mice reveal that B cell activation combined with antibody class switch recombination and somatic hypermutation do not benefit the control of experimental trypanosomosis

Thi Thu Hang NguyenRobin GuevarraStefan MagezMagdalena Radwanska

A1 Journal Article in PLOS PATHOGENS

The history of anti-trypanosome vaccine development shows that highly immunogenic and exposed pathogen-derived antigens are not necessarily good target candidates : enolase and ISG75 as examples

Stefan MagezZeng LiThi Thu Hang NguyenJoar Esteban Pinto TorresPieter Van WielendaeleMagdalena RadwanskaJakub BeganSebastian ZollYann G. -J. Sterckx

A1 Journal Article in PATHOGENS

2020

A critical Blimp-1-dependent IL-10 regulatory pathway in T cells protects from a lethal pro-inflammatory cytokine storm during acute experimental Trypanosoma brucei Infection

Carl De TrezBenoit StijlemansViki BockstalJennifer CnopsHannelie KorfJacques Van SnickGuy CaljonEric MurailleIan R. HumphreysLouis Boon et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

An unbiased immunization strategy results in the identification of enolase as a potential marker for nanobody-based detection of Trypanosoma evansi

Zeng LiJoar Esteban Pinto TorresJulie GoossensDidier VertommenGuy CaljonYann G. -J. SterckxStefan Magez

A1 Journal Article in VACCINES

Development of a recombinase polymerase amplification lateral flow assay for the detection of active Trypanosoma evansi infections

Zeng LiJoar Esteban Pinto TorresJulie GoossensBenoit StijlemansYann G-J SterckxStefan Magez

A1 Journal Article in PLOS NEGLECTED TROPICAL DISEASES

Establishment of a standardized vaccine protocol for the analysis of protective immune responses during experimental Trypanosome infections in mice

Magdalena RadwanskaThi Thu Hang NguyenSangphil MoonEmmanuel Tumininu ObishakinStefan Magez

Bookchapter in Trypanosomatids

Hepatocyte-derived IL-10 plays a crucial role in attenuating pathogenicity during the chronic phase of T. congolense infection

Benoit StijlemansHannelie KorfPatrick De BaetselierLea BrysJo A Van GinderachterStefan MagezCarl De Trez

A1 Journal Article in PLOS PATHOGENS

Infections with extracellular trypanosomes require control by efficient innate immune mechanisms and can result in the destruction of the mammalian humoral immune system

Stefan MagezJoar Esteban Pinto TorresEmmanuel Tumininu ObishakinMagdalena Radwanska

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Isolation of Trypanosoma brucei brucei infection-derived splenic marginal zone B cells based on CD1dHigh/B220High surface expression in a two-step MACS-FACS approach

Magdalena RadwanskaNick VereeckeStefan Magez

Bookchapter in Trypanosomatids

Structural and kinetic characterization of Trypanosoma congolense pyruvate kinase

Joar Esteban Pinto TorresMeng YuanJulie GoossensWim VerséesGuy CaljonPaul A. MichelsMalcolm D. WalkinshawStefan MagezYann G.-J. Sterckx

A1 Journal Article in MOLECULAR AND BIOCHEMICAL PARASITOLOGY

T. brucei infections abrogate diverse plasma cell-mediated effector B cell responses, independently of their specificity, affinity and host genetic background

Carl De TrezShahid KhanStefan Magez

A1 Journal Article in PLOS NEGLECTED TROPICAL DISEASES

2019

The trypanosomal transferrin receptor of trypanosoma brucei : a review

Christopher K. KariukiBenoit StijlemansStefan Magez

A1 Journal Article in TROPICAL MEDICINE AND INFECTIOUS DISEASE

Trypanosoma brucei brucei causes a rapid and persistent influx of neutrophils in the spleen of infected mice

Violette DeleeuwHien Thi Thu PhạmIsabel De PoorterIbo JanssensCarl De TrezMagdalena RadwanskaStefan Magez

A1 Journal Article in PARASITE IMMUNOLOGY

Using detergent-enhanced LAMP for African trypanosome detection in human cerebrospinal fluid and implications for disease staging

Dennis J GrabOlga V NikolskaiaBertrand CourtiouxOriel MM ThekisoeStefan MagezMaxim BogoradJ Stephen DumlerSylvie Bisser

A1 Journal Article in PLOS NEGLECTED TROPICAL DISEASES

2018

African Trypanosomiasis-associated anemia : the contribution of the interplay between parasites and the mononuclear phagocyte system

Benoit StijlemansPatrick De BaetselierStefan MagezJo A Van GinderachterCarl De Trez

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Coinfection with Trypanosoma brucei confers protection against cutaneous leishmaniasis

Lais PereiraFabiano OliveiraShannon TownsendSonia MetangmoClaudio MenesesIan N MooreClaudia I BrodskynJesus G ValenzuelaStefan MagezShaden Kamhawi

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

DNA detection of Trypanosoma evansi : diagnostic validity of a new assay based on loop-mediated isothermal amplification (LAMP)

Qunbo TongRui ChenQingming KongJulie GoossensMagdalena RadwanskaDi LouJianzu DingBin ZhengYixiu FuTianping Wang et al.

A1 Journal Article in VETERINARY PARASITOLOGY

Development of a nanobody-based lateral flow assay to detect active Trypanosoma congolense infections

Joar E Pinto TorresJulie GoossensJianzu DingZeng LiShaohong LuDidier VertommenPeter NaniimaRui ChenSerge MuyldermansYann G-J Sterckx et al.

A1 Journal Article in SCIENTIFIC REPORTS

Neutrophils enhance early Trypanosoma brucei infection onset

Guy CaljonDorien MabilleBenoît StijlemansCarl De TrezMassimiliano MazzoneFabienne Tacchini-CottierMarie MalissenJo A Van GinderachterStefan MagezPatrick De Baetselier et al.

A1 Journal Article in SCIENTIFIC REPORTS

STAT6 mediates footpad immunopathology in the absence of IL-12p40 following infection of susceptible BALB/c mice with Leishmania major

Florence KauffmannElyn MeertKaat de JongeYvon ElkrimDelphine Hanot MambresOlivier DenisEric MurailleStefan MagezCarl De Trez

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Salivarian trypanosomosis : a review of parasites involved, their global distribution and their interaction with the innate and adaptive mammalian host immune system

Magdalena RadwanskaNick VereeckeViolette DeleeuwJoar PintoStefan Magez

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

2017

African Trypanosomes undermine humoral responses and vaccine development : link with inflammatory responses?

Benoit StijlemansMagdalena RadwanskaCarl De TrezStefan Magez

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Experimental African trypanosome infection suppresses the development of multiple myeloma in mice by inducing intrinsic apoptosis of malignant plasma cells

Nathan De BeuleEline MenuMathieu BertrandMérédis FavreauElke De BruyneKen MaesKim De VeirmanMagdalena RadwanskaAfshin SamaliStefan Magez et al.

A1 Journal Article in ONCOTARGET

Functionalization of gold nanoparticles with nanobodies through physical adsorption

Julie GoossensHla SeinShaohong LuMagdalena RadwanskaSerge MuyldermansYann G-J SterckxStefan Magez

A1 Journal Article in ANALYTICAL METHODS

Nanobodies as tools to understand, diagnose, and treat African trypanosomiasis

Benoit StijlemansPatrick De BaetselierGuy CaljonJan Van Den AbbeeleJo A Van GinderachterStefan Magez

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Structural basis for the high specificity of a Trypanosoma congolense immunoassay targeting glycosomal aldolase

Joar PintoSteven OdongoFelicity LeeVaiva GaspariunaiteSerge MuyldermansStefan MagezYann G-J Sterckx

A1 Journal Article in PLOS NEGLECTED TROPICAL DISEASES

The non-mammalian MIF superfamily

Amanda SparkesPatrick De BaetselierKim RoelantsCarl De TrezStefan MagezJo A Van GinderachterGeert RaesRichard BucalaBenoît Stijlemans

A1 Journal Article in IMMUNOBIOLOGY

2016

An anti-proteome nanobody library approach yields a specific immunoassay for Trypanosoma congolense diagnosis targeting glycosomal aldolase

Steven OdongoYann GJ SterckxBenoit StijlemansDavita PillayTheo BaltzSerge MuyldermansStefan Magez

A1 Journal Article in PLOS NEGLECTED TROPICAL DISEASES

Comparative evaluation of the nested ITS PCR against the 18S PCR-RFLP in a survey of bovine trypanosomiasis in Kwale County, Kenya

Steven OdongoVincent DelespauxMaina NgothoSerkalem Mindaye BekkeleStefan Magez

A1 Journal Article in JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION

Immune evasion strategies of Trypanosoma brucei within the mammalian host : progression to pathogenicity

Benoit StijlemansGuy CaljonJan Van den AbbeeleJo A Van GinderachterStefan MagezCarl De Trez

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

In vivo characterization of two additional Leishmania donovani strains using the murine and hamster model

F KauffmannF DumetzS HendrickxE MurailleJC DujardinL MaesStefan MagezC De Trez

A1 Journal Article in PARASITE IMMUNOLOGY

Infection of mice by Trypanosoma brucei ameliorates host immune response against Brucella melitensis

A MachelartG PotembergC TruyensM RomanoE PaysC De TrezStefan MagezJJ LetessonE Muraille

MIF-mediated hemodilution promotes pathogenic anemia in experimental African trypanosomosis

Benoît StijlemansLea BrysHannelie KorfPawel Bieniasz-KrzywiecAmanda SparkesLiese VansintjanLin LengNele VanbekbergenMassimiliano MazzoneGuy Caljon et al.

A1 Journal Article in PLOS PATHOGENS

Maintenance of B cells during chronic murine Trypanosoma brucei gambiense infection

J CnopsF KauffmannC De TrezT BaltzJ KeirsseMagdalena RadwanskaE MurailleStefan Magez

A1 Journal Article in PARASITE IMMUNOLOGY

The enrichment of Histomonas meleagridis and its pathogen-specific protein analysis : a first step to shed light on its virulence

Anh Dao Nguyen PhamJan MastStefan MagezBruno GoddeerisSebastien C Carpentier

A1 Journal Article in AVIAN DISEASES

Trypanosoma brucei co-opts NK cells to kill splenic B2 B cells

Deborah FrenkelFengqiu ZhangPatrick GuirnaldaCarole HaynesViki BockstalMagdalena RadwanskaStefan MagezSamuel J Black

A1 Journal Article in PLOS PATHOGENS

2015

Curative drug treatment of trypanosomosis leads to the restoration of B-cell lymphopoiesis and splenic B-cell compartments

J CnopsV BockstalC De TrezMC MiquelMagdalena RadwanskaStefan Magez

A1 Journal Article in PARASITE IMMUNOLOGY

Detection of pathogen-specific antibodies by loop-mediated isothermal amplification

IE BurbulisK YamaguchiOV NikolskaiaST PriggeStefan MagezS BisserME RellerDJ Grab

A1 Journal Article in CLINICAL AND VACCINE IMMUNOLOGY

Development of a pHrodo-based assay for the assessment of in vitro and in vivo erythrophagocytosis during experimental trypanosomosis

Benoit StijlemansJennifer CnopsPeter NaniimaAxel VaastViki BockstalPatrick De BaetselierStefan Magez

A1 Journal Article in PLOS NEGLECTED TROPICAL DISEASES

Escape mechanisms of African trypanosomes : why trypanosomosis is keeping us awake

J CnopsStefan MagezC De Trez

A1 Journal Article in PARASITOLOGY

Experimental African trypanosome infection by needle passage or natural tsetse fly challenge thwarts the development of collagen-induced arthritis in DBA/1 prone mice via an impairment of antigen specific B cell autoantibody titers

Carl De TrezBrunette KatsandegwazaGuy CaljonStefan Magez

A1 Journal Article in PLOS ONE

IFN-γ mediates early B-cell loss in experimental African trypanosomosis

J CnopsC De TrezD BulteMagdalena RadwanskaB RyffelStefan Magez

A1 Journal Article in PARASITE IMMUNOLOGY

IL-27 signaling is crucial for survival of mice infected with African trypanosomes via preventing lethal effects of CD4+ T cells and IFNγ

Gongguan LiuJinjun XuHui WuDonglei SunXiquan ZhangXiaoping ZhuStefan MagezMeiqing Shi

A1 Journal Article in PLOS PATHOGENS

Iron homeostasis and trypanosoma brucei associated immunopathogenicity development : a battle/quest for iron

B StijlemansA BeschinStefan MagezJA Van GinderachterP De Baetselier

A1 Journal Article in BIOMED RESEARCH INTERNATIONAL

NK-, NKT- and CD8-derived IFNγ drives myeloid cell activation and erythrophagocytosis, resulting in trypanosomosis-associated acute anemia

Jennifer CnopsCarl De TrezBenoit StijlemansJiri KeirsseFlorence KauffmannMark BarkhuizenRoanne KeetonLouis BoonFrank BrombacherStefan Magez

A1 Journal Article in PLOS PATHOGENS

Nanobody conjugated PLGA nanoparticles for active targeting of African Trypanosomiasis

JL AriasJD Unciti-BrocetaJ MaceiraT del CastilloJ Hernandez-QueroStefan MagezM SorianoJA Garcia-Salcedo

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

Production, purification and crystallization of a trans-sialidase from Trypanosoma vivax

Carole LF HaynesPaul AmelootHans RemautNico CallewaertYan G-J SterckxStefan Magez

A1 Journal Article in ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS

Specific cell targeting therapy bypasses drug resistance mechanisms in African trypanosomiasis

Juan D Unciti-BrocetaJose L AriasJose MaceiraMiguel SorianoMatilde Ortiz-GonzalezJose Hemandez-QueroManuel Munoz-TorresHarry P de KoningStefan MagezJose A Garcia-Salcedo

A1 Journal Article in PLOS PATHOGENS

2014

Antibody-mediated control of Trypanosoma vivax infection fails in the absence of tumour necrosis factor

F La GrecaC HaynesB StijlemansC De TrezStefan Magez

A1 Journal Article in PARASITE IMMUNOLOGY

Chronic Trypanosoma congolense infections in mice cause a sustained disruption of the B-cell homeostasis in the bone marrow and spleen

E ObishakinC de TrezStefan Magez

A1 Journal Article in PARASITE IMMUNOLOGY

Generation of a nanobody targeting the paraflagellar rod protein of trypanosomes

Emmanuel ObishakinBenoit StijlemansJulien Santi-RoccaIsabel VandenbergheBart DevreeseSerge MuldermansPhilippe BastinStefan Magez

A1 Journal Article in PLOS ONE

Monovinyl sulfone beta-cyclodextrin. A flexible drug carrier system

T del CastilloJ Marales-SanfrutosF Santoyo-GonzalezStefan MagezFJ Lopez-JaramilloJA Garcia-Salcedo

A1 Journal Article in CHEMMEDCHEM

Utilizing nanobody technology to target non-immunodominant domains of VAR2CSA

Sisse B DitlevRaluca FloreaMorten A NielsenThor G TheanderStefan MagezPhilippe BoeufAli Salanti

A1 Journal Article in PLOS ONE

2013

Novel therapy based on camelid nanobodies

Juan Diego Unciti-BrocetaTeresa Del CastilloMiguel SorianoStefan MagezJose A Garcia-Salcedo

A2 Journal Article in THERAPEUTIC DELIVERY

2012

Adenylate cyclases of Trypanosoma brucei inhibit the innate immune response of the host

D SalmonG VanwalleghemY MoriasJ DenoeudC KrumbholzF LhommeS BachmaierM KadorJ GossmannFBS Dias et al.

A1 Journal Article in SCIENCE

Affinity is an important determinant of the anti-trypanosome activity of nanobodies

Guy CaljonBenoit StijlemansDirk SaerensJan Van Den AbbeeleSerge MuyldermansStefan MagezPatrick De Baetselier

A1 Journal Article in PLOS NEGLECTED TROPICAL DISEASES

Enrichment of Histomonas meleagridis

AD PhamC MommerJ De GussemStefan MagezBM Goddeeris

A4 Journal Article in COMMUNICATIONS IN AGRICULTURAL AND APPLIED BIOLOGICAL SCIENCES

In situ microscopy analysis reveals local innate immune response developed around Brucella infected cells in resistant and susceptible mice

Richard CopinMarie-Alice VitryDelphine Hanot MambresArnaud MachelartCarl De TrezJean-Marie VanderwindenStefan MagezShizuo AkiraBernhard RyffelYves Carlier et al.

A1 Journal Article in PLOS PATHOGENS

Tsetse salivary gland proteins 1 and 2 are high affinity nucleic acid binding proteins with residual nuclease activity

Guy CaljonKarin De RidderBenoit StijlemansMarc CoosemansStefan MagezPatrick De BaetselierJan Van den Abbeele

A1 Journal Article in PLOS ONE

Two unique IL-10 producing B cell subsets contribute to the host cytokine balance during Trypanosoma brucei infections

F KauffmannV BockstalJ CnopsC HaynesC De TrezStefan Magez

Unravelling the events leading to inflammation-induced trypanosomiasis-associated acute anemia

J CnopsV BockstalC HaynesC De TrezStefan Magez

Using microdialysis to analyse the passage of monovalent nanobodies through the blood-brain barrier

G CaljonV CaveliersT LahoutteB StijlemansGH GhassabehJ Van Den AbbeeleI SmoldersP De BaetselierY MichotteS Muyldermans et al.

A1 Journal Article in BRITISH JOURNAL OF PHARMACOLOGY

2011

Acute disruption of bone marrow B lymphopoiesis and apoptosis of transitional and marginal zone B cells in the spleen following a blood-stage Plasmodium chabaudi infection in mice

Viki BockstalNathalie GeurtsStefan Magez

A2 Journal Article in JOURNAL OF PARASITOLOGY RESEARCH

High affinity nanobodies against the Trypanosome brucei VSG are potent trypanolytic agents that block endocytosis

Benoit StijlemansGuy CaljonSenthil Kumar A NatesanDirk SaerensKatja ConrathDavid Perez-MorgaJeremy N SkepperAlexandros NikolaouLea BrysEtienne Pays et al.

A1 Journal Article in PLOS PATHOGENS

Insufficiently defined genetic background confounds phenotypes in transgenic studies as exemplified by malaria infection in Tlr9 knockout mice

Nathalie GeurtsErik MartensSebastien VerhenneNatacha LaysGreet ThijsStefan MagezBenedicte CauweSandra LiHubertine HeremansGhislain Opdenakker et al.

A1 Journal Article in PLOS ONE

Mouse models for pathogenic African trypanosomes : unravelling the immunology of host-parasite-vector interactions

Stefan MagezG Caljon

A1 Journal Article in PARASITE IMMUNOLOGY

T. brucei infection reduces B lymphopoiesis in bone marrow and truncates compensatory splenic lymphopoiesis through transitional B-cell apoptosis

Viki BockstalPatrick GuirnaldaGuy CaljonRadhika GoenkaJanice C TelferDeborah FrenkelMagdalena RadwanskaStefan MagezSamuel J Black

A1 Journal Article in PLOS PATHOGENS

Vaccination against trypanosomiasis : can it be done or is the trypanosome truly the ultimate immune destroyer and escape artist?

Florencia La GrecaStefan Magez

A1 Journal Article in HUMAN VACCINES

2010

African trypanosomiasis : new insights for disease control : preface

JM SternbergSJ BlackStefan Magez

Editorial material

Current status of vaccination against African trypanosomiasis

Stefan MagezGuy CalhonThao TranBenoit StijlemansMagdalena Radwanska

A1 Journal Article in PARASITOLOGY

Parasite-induced B-cell apoptosis results in loss of specific protective anti-trypanosome antibody responses, and abolishment of vaccine induced protective memory responses.

Stefan MagezV BockstalF BrombacherS BlackMagdalena Radwanska

Scrutinizing the mechanisms underlying the induction of anemia of inflammation through GPI-mediated modulation of macrophage activation in a model of African trypanosomiasis

B StijlemansA VankrunkelsvenL BrysG RaesStefan MagezP De Baetselier

A1 Journal Article in MICROBES AND INFECTION

The central role of macrophages in trypanosomiasis-associated anemia : rationale for therapeutical approaches

Benoit StijlemansAnn VankrunkelsvenGuy CaljonViki BockstalMartin GuilliamsTom BosschaertsAlain BeschinGeert RaesStefan MagezPatrick De Baetselier

A2 Journal Article in ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS

2009

African trypanosomiasis and antibodies : implications for vaccination, therapy and diagnosis

Stefan MagezMagdalena Radwanska

A1 Journal Article in FUTURE MICROBIOLOGY

Camelid immunoglobulins and nanobody technology

S MuyldermansTN BaralVC RetarnozzoP De BaetselierE De GenstJ KinneH LeonhardtStefan MagezVK NguyenH Revets et al.

A1 Journal Article in VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY

Receptor-mediated and lectin-like activities of carp (cyprinus carpio) TNF-alpha

M ForlenzaStefan MagezJP ScharsackA WestphalHFJ SavelkoulGF Wiegertjes

A1 Journal Article in JOURNAL OF IMMUNOLOGY

iNOS-producing inflammatory dendritic cells constitute the major infected cell type during the chronic Leishmania major infection phase of C57BL/6 resistant mice

Carl De TrezStefan MagezShizuo AkiraBernhard RyffelYves CarlierEric Muraille

A1 Journal Article in PLOS PATHOGENS

2008

Camel antibodies for therapeutic and research applications

Cecile VinckeMireille PellisToya Nath BaralBenoit StijlemansSergei TillibUlrich RothbauerHeinrich LeonhardtKatja ConrathStefan MagezU Wernery et al.

Contributions of experimental mouse models to the understanding of African trypanosomiasis

Nicolas Antoine-MoussiauxStefan MagezDaniel Desmecht

A1 Journal Article in TRENDS IN PARASITOLOGY

Interleukin-12p70 deficiency increases survival and diminishes pathology in Trypanosoma congolense infection

Mark BarkhuizenStefan MagezBernhard RyffelFrank Brombacher

A1 Journal Article in JOURNAL OF INFECTIOUS DISEASES

Parallel selection of multiple anti-infectome nanobodies without access to purified antigens

Dirk SaerensBenoît StijlemansToya Nath BaralGiang Thanh Nguyen ThiUlrich WerneryStefan MagezPatrick De BaetselierSerge MuyldermansKatja Conrath

A1 Journal Article in JOURNAL OF IMMUNOLOGICAL METHODS

Role of iron homeostasis in trypanosomiasis-associated anemia

Benoît StijlemansAnn VankrunkelsvenLea BrysStefan MagezPatrick De Baetselier

A1 Journal Article in IMMUNOBIOLOGY

Stimulation of Toll-like receptor 3 and 4 induces interleukin-1β maturation by caspase-8

Jonathan MaelfaitElisabeth VercammenSophie JanssensPeter SchotteMira HaegmanStefan MagezRudi Beyaert

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

The role of B-cells and IgM antibodies in parasitemia, anemia, and VSG switching in Trypanosoma brucei-infected mice

Stefan MagezAnita SchwegmannRobert AtkinsonFilip ClaesMichael DrennanPatrick De BaetselierFrank Brombacher

A1 Journal Article in PLOS PATHOGENS

The role of TNF and MYD88 in the induction of B cell pathology following Trypanosoma brucei infection

V BockstalP GuirnaldaD FrenkelStefan MagezS Black

Trypanosomiasis-induced B cell apoptosis results in loss of protective anti-parasite antibody responses and abolishment of vaccine-induced memory responses

Magdalena RadwanskaPatrick GuirnaldaCarl De TrezBernard RyffelSamuel BlackStefan Magez

A1 Journal Article in PLOS PATHOGENS

2007

A glycosylphosphatidylinositol-based treatment alleviates Trypanosomiasis-associated immunopathology

Benoit StijlemansToya Nath BaralMartin GuilliamsLea BrysJohanna KorfMichael DrennanJan Van Den AbbeelePatrick De BaetselierStefan Magez

A1 Journal Article in JOURNAL OF IMMUNOLOGY

African trypanosomosis : from immune escape and immunopathology to immune intervention

Benoît StijlemansMartin GuilliamsGeert RaesAlain BeschinStefan MagezPatrick De Baetselier

A1 Journal Article in VETERINARY PARASITOLOGY

Control of Trypanosoma evansi infection is IgM mediated and does not require a type I inflammatory response

Toya Nath BaralPatrick De BaetselierFrank BrombacherStefan Magez

A1 Journal Article in JOURNAL OF INFECTIOUS DISEASES

Deletion of IL-4Rα on CD4 T cells renders BALB/c mice resistant to Leishmania major infection

Magdalena RadwanskaAntony J CutlerJ Claire HovingStefan MagezChristoph HolscherAndreas BohmsBerenice ArendseRichard KirschThomas HunigJames Alexander et al.

A1 Journal Article in PLOS PATHOGENS

Identification of a tryptophan-like epitope borne by the variable surface glycoprotein (VSG) of African trypanosomes

S SemballaMC Okomo-AssoumouP HolzmullerP BüscherStefan MagezJL LemesreS DaulouedeP CourtoisM GeffardP Vincendeau

A1 Journal Article in EXPERIMENTAL PARASITOLOGY

Interleukin‐12p70-dependent interferon‐γ production is crucial for resistance in African trypanosomiasis

Mark BarkhuizenStefan MagezRobert A AtkinsonFrank Brombacher

A1 Journal Article in JOURNAL OF INFECTIOUS DISEASES

Tumor necrosis factor (TNF) receptor-1 (TNFp55) signal transduction and macrophage‐derived soluble TNF are crucial for nitric oxide-mediated Trypanosoma congolense parasite killing

Stefan MagezMagdalena RadwanskaMichael DrennanLizette FickToya Nath BaralNasiema AllieMuazzam JacobsSergei NedospasovFrank BrombacherBernard Ryffel et al.

A1 Journal Article in JOURNAL OF INFECTIOUS DISEASES

2006

Experimental therapy of African trypanosomiasis with a nanobody-conjugated human trypanolytic factor

Toya Nath BaralStefan MagezBenoît StijlemansKatja ConrathBenoit VanhollebekeEtienne PaysSerge MuyldermansPatrick De Baetselier

A1 Journal Article in NATURE MEDICINE

Interferon‐γ and nitric oxide in combination with antibodies are key protective host immune factors during Trypanosoma congolense Tc13 Infections

Stefan MagezMagdalena RadwanskaMichael DrennanLizette FickToya Nath BaralFrank BrombacherPatrick De Baetselier

A1 Journal Article in JOURNAL OF INFECTIOUS DISEASES

Traitement expérimental de la trypanosomiase africaine par le facteur trypanolytique humain combiné à un nanocorps

Toya Nath BaralStefan MagezBenoit StijlemansKatja ConrathBenoit VanhollebekeEtienne PaysSerge MuyldermansPatrick De Baetselier

A2 Journal Article in MS. MÉDECINE/SCIENCES

Tsetse fly saliva accelerates the onset of Trypanosoma brucei infection in a mouse model associated with a reduced host inflammatory response

Guy CaljonJan Van Den AbbeeleBenoit StijlemansMarc CoosemansPatrick De BaetselierStefan Magez

A1 Journal Article in INFECTION AND IMMUNITY

Tsetse fly saliva biases the immune response to Th2 and induces anti-vector antibodies that are a useful tool for exposure assessment

Guy CaljonJan Van Den AbbeeleJeremy M SternbergMarc CoosemansPatrick De BaetselierStefan Magez

A1 Journal Article in INTERNATIONAL JOURNAL FOR PARASITOLOGY

2005

The induction of a type 1 immune response following a Trypanosoma brucei infection is MyD88 dependent

MB DrennanB StijlemansJ Van Den AbbeeleVJ QuesniauxM BarkhuizenF BrombacherP De BaetselierB RyffelStefan Magez

A1 Journal Article in JOURNAL OF IMMUNOLOGY

2004

Efficient targeting of conserved cryptic epitopes of infectious agents by single domain antibodies : African trypanosomes as paradign

Benoît StijlemansKatja ConrathVirna Cortez-RetamozoHoang Van XongLode WynsPeter SenterHilde RevetsPatrick De BaetselierSerge MuyldermansStefan Magez

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Functional convergence of invertebrate and vertebrate cytokine-like molecules based on a similar lectin-like activity

A BeschinM BilejStefan MagezR LucasP De Baetselier

Bookchapter in Invertebrate cytokines and the phylogeny of immunity facts and paradoxes

P75 tumor necrosis factor-receptor shedding occurs as a protective host response during African trypanosomiasis

Stefan MagezCarine TruyensMakram MerimiMagdalena RadwanskaBenoît StijlemansPeter BrouckaertFrank BrombacherEtienne PaysPatrick De Baetselier

A1 Journal Article in JOURNAL OF INFECTIOUS DISEASES

2003

Antibodies raised against the flagellar pocket fraction of Trypanosoma brucei preferentially recognize HSP60 in cDNA expression library

Magdalena RadwanskaStefan MagezNathalie DumontAnnette PaysDerek NolanEtienne Pays

A1 Journal Article in PARASITE IMMUNOLOGY

2002

Comparative analysis of antibody responses against HSP60, invariant surface glycoprotein 70, and variant surface glycoprotein reveals a complex antigen-specific pattern of immunoglobulin isotype switching during infection by Trypanosoma brucei

Magdalena RadwanskaStefan MagezA MichelB StijlemansM GeuskensE Pays

A1 Journal Article in INFECTION AND IMMUNITY

Control of experimental Trypanosoma brucei infections occurs independently of lymphotoxin-α induction

Stefan MagezB StijlemansG CaljonHP EugsterP De Baetselier

A1 Journal Article in INFECTION AND IMMUNITY

Direct detection and identification of African trypanosomes by fluorescence in situ hybridization with peptide nucleic acid probes

Magdalena RadwanskaStefan MagezH Perry-O'KeefeH StenderJ CoullJM SternbergP BuscherJJ Hyldig-Nielsen

A1 Journal Article in JOURNAL OF CLINICAL MICROBIOLOGY

Novel primer sequences for polymerase chain reaction-based detection of Trypanosoma brucei gambiense.

Magdalena RadwanskaFilip ClaesStefan MagezEddy MagnusDavid Perez-MorgaEtienne PaysPhilippe Büscher

A1 Journal Article in AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Selective pressure can influence the resistance of Trypanosoma congolense to normal human serum.

Hoang Van XongPatrick De BaetselierEtienne PaysStefan Magez

A1 Journal Article in EXPERIMENTAL PARASITOLOGY

The functional relevance of the lectin-like activities of cytokines : TNF as an illustrative example

P De BaetselierA BeschinR LucasM BilejB StijlemansStefan Magez

The serum resistance-associated gene as a diagnostic tool for the detection of Trypanosoma brucei rhodesiense

Magdalena RadwanskaMustapha ChamekhLuc VanhammeFilip ClaesStefan MagezEddy MagnusPatrick de BaetselierPhilippe BüscherEtienne Pays

A1 Journal Article in AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

VSG-GPI anchors of African trypanosomes : their role in macrophage activation and induction of infection-associated immunopathology

Stefan MagezB StijlemansT BaralP De Baetselier

A1 Journal Article in MICROBES AND INFECTION

2001

A conserved flagellar pocket exposed high mannose moiety is used by African trypanosomes as a host cytokine binding molecule

Stefan MagezMagdalena RadwanskaBenoı̂t StijlemansHoang Van XongEtienne PaysPatrick De Baetselier

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

2000

Trypanosoma brucei brucei infection impairs MHC class II antigen presentation capacity of macrophages

B NamangalaL BrysStefan MagezP De BaetselierA Beschin

A1 Journal Article in PARASITE IMMUNOLOGY

1999

Convergent evolution of cytokines

Alain BeschinMartin BilejLea BrysEls TorreeleRudolf LucasStefan MagezPatrick De Baetselier

A1 Journal Article in NATURE

Hemozoin is a key factor in the induction of malaria-associated immunosuppression

Tatiana ScorzaStefan MagezLea BrysPatrick De Baetselier

A1 Journal Article in PARASITE IMMUNOLOGY

Tumor necrosis factor alpha is a key mediator in the regulation of experimental Trypanosoma brucei infections

Stefan MagezMagdalena RadwanskaA BeschinK SekikawaP De Baetselier

A1 Journal Article in INFECTION AND IMMUNITY

1998

TNF-alpha plays a key role in the regulation of the experimental infection with Trypanosoma brucei

Stefan MagezA BeschinMagdalena RadwanskaP De Baetselier

The glycosyl-inositol-phosphate and dimyristoylglycerol moieties of the glycosylphosphatidylinositol anchor of the trypanosome variant-specific surface glycoprotein are distinct macrophage-activating factors

Stefan MagezB StijlemansMagdalena RadwanskaE PaysMAJ FergusonP De Baetselier

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Trypanosoma brucei infection elicits nitric oxide-dependent and nitric oxide-independent suppressive mechanisms

A BeschinL BrysStefan MagezMagdalena RadwanskaP De Baetselier

A1 Journal Article in JOURNAL OF LEUKOCYTE BIOLOGY

1997

Generation of a mouse tumor necrosis factor mutant with antiperitonitis and desensitization activities comparable to those of the wild type but with reduced systemic toxicity

R LucasB EchtenacherE SablonP JuillardStefan MagezJ LouY DonatiF BosmanA Van de VoordeL Fransen et al.

A1 Journal Article in INFECTION AND IMMUNITY

Specific uptake of tumor necrosis factor-α is involved in growth control of Trypanosoma brucei

Stefan MagezM GeuskensA BeschinH del FaveroH VerschuerenR LucasE PaysP de Baetselier

A1 Journal Article in JOURNAL OF CELL BIOLOGY

1994

Mapping the lectin-like activity of tumor necrosis factor

R LucasStefan MagezR De LeysL FransenJP ScheerlinckM RampelbergE SablonP De Baetselier

A1 Journal Article in SCIENCE

1993

A role for TNF during African trypanosomiasis : involvement in parasite control, immunosuppression and pathology

R LucasStefan MagezB SongaA DarjiR HamersP de Baetselier

A1 Journal Article in RESEARCH IN IMMUNOLOGY

Murine tumour necrosis factor plays a protective role during the initial phase of the experimental infection with Trypanosoma brucei brucei

Stefan MagezRudol LucasAyub DarjiEmmanuel Bajyana SongaRaymond HamersPatrick De Baetselier

A1 Journal Article in PARASITE IMMUNOLOGY

1991

Mechanisms underlying trypanosome-elicited immunosuppression

A DarjiR LucasStefan MagezE TorreeleJ PalaciosM SileghemEB SongaR HamersP De Baetselier

A1 Journal Article in ANNALES DE LA SOCIETE BELGE DE MEDECINE TROPICALE