Research Explorer

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Researcher

Sophie Van Welden

Publications & Research Data

Awards & Distinctions

27 Results

2025

Characterisation of a human multi-organ-on-chip model to unravel gut-blood-brain communication

Laure MaesSophie Van WeldenRoosmarijn VandenbrouckeDebby Laukens

2024

OP077 - RXC008: FIRST-IN-CLASS GASTROINTESTINAL-TARGETED POTENT PAN-ROCK INHIBITOR FOR TREATMENT OF FIBROSTENOTIC CROHN’S DISEASE

Elaine KilgourKirsty HouslayAmy MarshallManuela La MontagnaKatie AndersonSimon BosSophie Van WeldenJade CelisKay EckersleyClifford D. Jones et al.

2023

A comprehensive metabolite fingerprint of fibrostenosis in patients with Crohn’s disease

Simon BosTriana Lobatón OrtegaMartine De VosSophie Van WeldenVera PlekhovaEllen De PaepeLynn VanhaeckeDebby Laukens

A1 Journal Article in SCIENTIFIC REPORTS

Effect on colorectal cancer bioenergetics by chronic exposure to red meat metabolites

Elien AlderweireldtCharlotte GrootaertSophie Van WeldenDebby LaukensAndreja RajkovicJohn Van CampOlivier De Wever

Kupffer cells contested as early drivers in the pathogenesis of primary sclerosing cholangitis

Kevin De MuynckBart VanderborghtFederico Francesco De PontiEva GijbelsSophie Van WeldenMartin GuilliamsCharlotte ScottAlain BeschinMathieu VinkenSander Lefere et al.

A1 Journal Article in AMERICAN JOURNAL OF PATHOLOGY

MRI texture analysis of T2-weighted images is preferred over magnetization transfer imaging for readily longitudinal quantification of gut fibrosis

Isabelle De KockSimon BosLouke DelrueSophie Van WeldenPeter BunyardPieter HindryckxMartine De VosGeert VilleirsDebby Laukens

A1 Journal Article in EUROPEAN RADIOLOGY

ROR gamma t inhibition ameliorates IL-23 driven experimental psoriatic arthritis by predominantly modulating gamma delta-T cells

Céline MortierEric GraceyJulie CoudenysTeddy ManuelloTine DecruyMargaux MaelegheerFlore StappersElisabeth GilisDjoere GaublommeLuc Van Hoorebeke et al.

A1 Journal Article in RHEUMATOLOGY

2022

Magnetic resonance texture analysis is superior to magnetization transfer imaging for longitudinal assessment of fibrosis in experimental colitis

Simon BosIsabelle De KockSophie Van WeldenPeter BunyardPieter HindryckxMartine De VosGeert VilleirsDebby Laukens

Role of integrin expression in the prediction of response to vedolizumab : a prospective real‐life multicentre cohort study

Cara De GalanBryan GonzalesSophie Van WeldenSimon TavernierTriana Lobatón OrtegaWouter Van MoerkerckeBeatrijs StrubbeHarald PeetersElisabeth MackenMartine De Vos et al.

A1 Journal Article in CLINICAL AND TRANSLATIONAL MEDICINE

The quorum sensing peptide EntF* promotes colorectal cancer metastasis in mice : a new factor in the host-microbiome interaction

Evelien WynendaeleNathan DebunneYorick JanssensAnton De SpiegeleerFrederick VerbekeLiesa TackSophie Van WeldenEvy GoossensDaniel KnappeRalf Hoffmann et al.

A1 Journal Article in BMC BIOLOGY

2021

Can serum metabolomics discriminate the Crohn’s disease fibrostenotic phenotype?

Simon BosSophie Van WeldenMartine De VosPieter HindryckxTriana Lobatón OrtegaLynn VanhaeckeDebby Laukens

Early prediction of response to vedolizumab in patients with active inflammatory bowel disease : a prospective real-life multicentre cohort study

Cara De GalanGerard Bryan GonzalesSophie Van WeldenSimon TavernierTriana Lobatón OrtegaWouter Van MoerkerckeBeatrijs StrubbeHarald PeetersElisabeth MackenMartine De Vos et al.

Long-term environmental hypoxia does not impact experimental Crohn's like ileitis

Cara De GalanSophie Van WeldenTriana Lobatón OrtegaPieter HindryckxMartine De VosDebby Laukens

Long-term environmental hypoxia exposure and haematopoietic prolyl hydroxylase-1 deletion do not impact experimental Crohn's like ileitis

Cara De GalanMartine De VosPieter HindryckxDebby LaukensSophie Van Welden

A1 Journal Article in BIOLOGY-BASEL

2020

Integrin expression changes on the T cells subsets influence the response to vedolizumab in inflammatory bowel disease patients

Cara De GalanSophie Van WeldenSimon BosSimon TavernierTriana Lobatón OrtegaBryan GonzalesWouter Van MoerkerckeBeatrijs StrubbeHarald PeetersElisabeth Macken et al.

2019

Integrin expression changes on the T cell subsets influence the response to vedolizumab in inflammatory bowel disease patients

Cara De GalanSophie Van WeldenSimon BosSimon TavernierTriana Lobatón OrtegaBryan GonzalesWouter Van MoerkerckeBeatrijs StrubbeHarald PeetersElisabeth Macken et al.

2017

Haematopoietic prolyl hydroxylase-1 deficiency promotes M2 macrophage polarization and is both necessary and sufficient to protect against experimental colitis

Sophie Van WeldenMartine De VosBen WielockxSimon TavernierMelissa DullaersSara NeytBenedicte DescampsLindsey DevisscherSarah DevrieseLien Van den Bossche et al.

A1 Journal Article in JOURNAL OF PATHOLOGY

Intestinal hypoxia and hypoxia-induced signalling as therapeutic targets for IBD

Sophie Van WeldenAndrew C SelfridgePieter Hindryckx

A1 Journal Article in NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY

Prolyl hydroxylase domain-containing protein 1 as potential therapeutic target for inflammatory bowel disease

Sophie Van WeldenDebby LaukensPieter Hindryckx

T84 monolayers are superior to Caco-2 as a model system of colonocytes

Sarah DevrieseLien Van den BosscheSophie Van WeldenTom HolvoetIris PinheiroPieter HindryckxMartine De VosDebby Laukens

A1 Journal Article in HISTOCHEMISTRY AND CELL BIOLOGY

Tauroursodeoxycholic acid protects bile acid homeostasis under inflammatory conditions and dampens Crohn’s disease-like ileitis

Lien Van den BosscheDaniel BorsboomSarah DevrieseSophie Van WeldenTom HolvoetLindsey DevisscherPieter HindryckxMartine De VosDebby Laukens

A1 Journal Article in LABORATORY INVESTIGATION

Treatment of intestinal fibrosis in experimental inflammatory bowel disease by the pleiotropic actions of a local Rho kinase inhibitor

Tom HolvoetSarah DevrieseKarolien CastermansSandro BolandDirk LeysenYves-Paul VandewynckelLindsey DevisscherLien Van den BosscheSophie Van WeldenMelissa Dullaers et al.

A1 Journal Article in GASTROENTEROLOGY

Ursodeoxycholic acid and its taurine/glycine conjugated species reduce colitogenic dysbiosis and equally suppress experimantal colitis in mice

Lien Van den BosschePieter HindryckxLindsey DevisscherSarah DevrieseSophie Van WeldenTom HolvoetRamiro Vilchez VargasMarius VitalDietmar PieperJulie Vanden Bussche et al.

Ursodeoxycholic acid and its taurine/glycine conjugated species reduce colitogenic dysbiosis and equally suppress experimental colitis in mice

Lien Van den BosschePieter HindryckxLindsey DevisscherSarah DevrieseSophie Van WeldenTom HolvoetRamiro Vilchez VargasMarius VitalDietmar H PieperJulie Vandenbussche et al.

A1 Journal Article in APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Ursodeoxycholic acid and its taurine/glycine conjugated species reduce colitogenic dysbiosis and equally suppress experimental colitis in mice

Lien Van den BosschePieter HindryckxLindsey DevisscherSarah DevrieseSophie Van WeldenTom HolvoetRamiro Vilchez VargasMarius VitalDietmar H PieperJulie Vandenbussche et al.

2014

Ly49E Expression on CD8αα-expressing intestinal intraepithelial lymphocytes plays no detectable role in the development and progression of experimentally induced inflammatory bowel diseases

Aline Van AckerJessica FiltjensSophie Van WeldenSylvie TaveirneEls Van AmmelMandy VanheesLindsey DevisscherTessa KerreTom TaghonBart Vandekerckhove et al.

A1 Journal Article in PLOS ONE

2013

Differential expression of prolyl hydroxylase 1 in patients with ulcerative colitis versus patients with Crohn's disease/infectious colitis and healthy controls

Sophie Van WeldenDebby LaukensLiesbeth FerdinandeMartine De VosPieter Hindryckx

A1 Journal Article in JOURNAL OF INFLAMMATION-LONDON