Research Explorer

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Researcher

Sofie Peirs

27 Results

2021

RUNX2 regulates leukemic cell metabolism and chemotaxis in high-risk T cell acute lymphoblastic leukemia

Filip MatthijssensNitesh D. SharmaMonique NysusChristian K. NicklHuining KangDominique R. PerezBéatrice LintermansWouter Van LoockeJuliette RoelsSofie PeirsLisa DemoenTim PietersLindy ReunesTim LammensBarbara De MoerlooseFilip Van NieuwerburghDieter DeforceLaurence C. CheungRishi S. KotechaMartijn RisseeuwSerge Van CalenberghTakeshi TakaradaYukio YonedaFrederik W. van DelftRichard B. LockSeth D. MerkleyAlexandre ChigaevLarry A. SklarCharles G. MullighanMignon L. LohStuart S. WinterStephen P. HungerSteven GoossensEliseo F. CastilloWojciech OrnatowskiPieter Van VlierbergheKsenia Matlawska-Wasowska

A1 Journal Article in JOURNAL OF CLINICAL INVESTIGATION

The spleen as a sanctuary site for residual leukemic cells following ABT-199 monotherapy in ETP-ALL

Alessandra Di GrandeSofie PeirsPaul D. DonovanMaaike Van TrimpontJulie MorscioBéatrice LintermansLindy ReunesNiels VandammeSteven GoossensHien Anh NguyenArnon LavieRichard B. LockJochen H. M. PrehnPieter Van VlierbergheTriona Ní Chonghaile

A1 Journal Article in BLOOD ADVANCES

2019

Fanconi-BRCA pathway mutations in childhood T-cell acute lymphoblastic leukemia

Gayle P PouliotJames DegarLaura HinzeBose KochupurakkalChau D VoMelissa A BurnsLisa MoreauChirag GanesaJustine RoderickSofie PeirsBjörn MentenMignon L LohStephen P HungerLewis B SilvermanMarian H HarrisKristen E StevensonDavid M WeinstockAndrew P WengPieter Van VlierbergheAlan D D’AndreaAlejandro Gutierrez

A1 Journal Article in PLOS ONE

Genetic characterization and therapeutic targeting of MYC-rearranged T cell acute lymphoblastic leukaemia

Gloria MilaniFilip MatthijssensWouter Van LoockeKaat DurinckJuliette RoelsSofie PeirsMorgan ThénozTim PietersLindy ReunesBéatrice LintermansNiels VandammeTim LammensNadine Van RoyFilip Van NieuwerburghDieter DeforceClaire SchwabSusana RaimondiLuciano Dalla PozzaAndrew J CarrollBarbara De MoerlooseYves BenoitSteven GoossensGeert BerxChristine J HarrisonGiuseppe BassoHélène CavéRosemary SuttonVahid AsnafiJules MeijerinkCharles MullighanMignon LohPieter Van Vlierberghe

A1 Journal Article in BRITISH JOURNAL OF HAEMATOLOGY

USP7 cooperates with NOTCH1 to drive the oncogenic transcriptional program in T-cell leukemia

Qi JinCarlos A MartinezKelly M ArcipowskiYixing ZhuBlanca T Gutierrez-DiazKenneth K WangMegan R JohnsonAndrew G VolkFeng WangJian WuCharles GroveHui WangIvan SokirniyPaul M ThomasYoung Ah GooNebiyu A AbshiruNobuko HijiyaSofie PeirsNiels VandammeGeert BerxSteven GoossensStacy A MarshallEmily J RendlemanYoh-hei TakahashiLu WangRadhika RawatElizabeth T BartomClayton K CollingsPieter Van VlierbergheAlexandros StrikoudisStephen KellyBeatrix UeberheideChristine MantisIrawati KandelaJean-Pierre BourquinBeat BornhauserValentina SerafinSilvia BresolinMaddalena PaganinBenedetta AccordiGiuseppe BassoNeil L KelleherJoseph WeinstockSuresh KumarJohn D CrispinoAli ShilatifardPanagiotis Ntziachristos

A1 Journal Article in CLINICAL CANCER RESEARCH

2018

A novel L-asparaginase with low L-glutaminase coactivity is highly efficacious against both T- and B-cell acute lymphoblastic leukemias in vivo

Hien Anh NguyenYing SuJenny Yu ZhangAleksandar AntanasijevicMichael CaffreyAmanda M SchalkLi LiuDamiano RondelliAnnie OhDolores L MahmudMaarten C BoslandAndre Kajdacsy-BallaSofie PeirsTim LammensVeerle MondelaersBarbara De MoerlooseSteven GoossensMichael J SchlichtKasim K KabirovAlexander V LyubimovBradley J MerrillYogen SaunthararajahPieter Van VlierbergheArnon Lavie

A1 Journal Article in CANCER RESEARCH

PRC2 loss induces chemoresistance by repressing apoptosis in T cell acute lymphoblastic leukemia

Ingrid M AriësKimberly BodaarSalmaan A KarimTriona Ni ChonghaileLaura HinzeMelissa A BurnsMaren PfirrmannJames DegarJack T LandriganSebastian BalbachSofie PeirsBjörn MentenRandi IsenhartKristen E StevensonDonna S NeubergMeenakshi DevidasMignon L LohStephen P HungerDavid T TeacheyKaren R RabinStuart S WinterKimberly P DunsmoreBrent L WoodLewis B SilvermanStephen E SallanPieter Van VlierbergheStuart H OrkinBirgit KnoechelAnthony G LetaiAlejandro Gutierrez

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

Pre-clinical evaluation of second generation PIM inhibitors for the treatment of T-cell acute lymphoblastic leukemia and lymphoma

Renate De SmedtSofie PeirsJulie MorscioFilip MatthijssensJuliette RoelsLindy ReunesBéatrice LintermansSteven GoossensTim LammensNadine Van RoyAurore TouzartSilvia JenniYi-Chien TsaiFederica LovisaLara MussolinValentina SerafinFilip Van NieuwerburghDieter DeforceAnne UyttebroeckThomas TousseynBirgit BurkhardtWolfram KlapperBarbara De MoerlooseYves BenoitElizabeth MacintyreJean-Pierre BourquinGiuseppe BassoBenedetta AccordiBeat BornhauserJules MeijerinkPeter VandenberghePieter Van Vlierberghe

A1 Journal Article in HAEMATOLOGICA

2017

Novel molecular insights and targeted therapies in T-cell acute lymphoblastic leukaemia

Editorial material

Novel molecular insights and targeted therapies in T-cell acute lymphoblastic leukemia

Sofie PeirsBruce PoppePieter Van Vlierberghe

Oncogenic ZEB2 activation drives sensitivity toward KDM1A inhibition in T-cell acute lymphoblastic leukemia

Steven GoossensSofie PeirsWouter Van LoockeJueqiong WangMina TakawyFilip MatthijssensStefan E SondereggerKatharina HaighThao NguyenNiels VandammeMagdaline CostaCatherine CarmichaelFilip Van NieuwerburghDieter DeforceOded KleifeldDavid J CurtisGeert BerxPieter Van VlierbergheJody J Haigh

A1 Journal Article in BLOOD

Targeting BET proteins improves the therapeutic efficacy of BCL-2 inhibition in T-cell acute lymphoblastic leukemia

Sofie PeirsV FrismantasFilip MatthijssensW Van LoockeTim PietersNiels VandammeBéatrice LintermansMP DobayGeert BerxBruce PoppeSteven GoossensBC BornhauserJ-P BourquinPieter Van Vlierberghe

A1 Journal Article in LEUKEMIA

2016

A quantitative proteomics approach identifies ETV6 and IKZF1 as new regulators of an ERG-driven transcriptional network

Ashwin UnnikrishnanYi Fang GuanYizhou HuangDominik BeckJulie AI ThomsSofie PeirsKathy KnezevicShiyong MaInge Van de WalleIneke de JongZara AliLing ZhongMark J RafteryTom TaghonJonas LarssonKaren L MacKenziePieter Van VlierbergheJason WH WongJohn E Pimanda

A1 Journal Article in NUCLEIC ACIDS RESEARCH

BRD4 inhibition improves the efficacy of ABT-199 in T-cell acute lymphoblastic leukemia

Sofie PeirsFilip MatthijssensTim PietersNiels VandammeGeert BerxBruce PoppePieter Van Vlierberghe

BRD4 inhibition improves the efficacy of ABT-199 in T-cell acute lymphoblastic leukemia

Sofie PeirsFilip MatthijssensTim PietersNiels VandammeGeert BerxBruce PoppePieter Van Vlierberghe

Fast generation of conditional ROSA26-based mouse models that recapitulate genomic events in human T-ALL

Tim PietersSteven GoossensSara T'SasLieven HaenebalckeTino HochepiedBéatrice LintermansSofie PeirsFilip MatthijssensJ HaighGeert BerxPieter Van Vlierberghe

Genetic characterization and therapeutic targeting of MYC translocated pediatric T-cell acute lymphoblastic leukemia

Gloria MilaniKaat DurinckFilip MatthijssensSofie PeirsTim PietersLindy ReunesBéatrice LintermansNiels VandammeTim LammensYunlei LiClaire SchwabSusana RaimondiBarbara De MoerlooseYves BenoitGeert BerxChristine HarrisonGiuseppe BassoHelene CaveRosemary SuttonVahid AsnafiCharles MullighanJules MeijerinkMignon LohPieter Van Vlierberghe

Oncogenic ZEB2 activation drives sensitivity towards LSD1 inhibition in T-Cell acute lymphoblastic leukemia

Steven GoossensSofie PeirsGeert BerxPieter Van VlierbergheJody J Haigh

Targeting BET family proteins improves the efficacy of ABT-199 in T-cell acute lymphoblastic leukemia

Sofie PeirsFilip MatthijssensBéatrice LintermansTim PietersNiels VandammeGeert BerxBruce PoppePieter Van Vlierberghe

Targeting BET family proteins improves the therapeutic efficacy of BCL-2 inhibition in T-cell acute lymphoblastic leukemia

Sofie PeirsViktoras FrismantasFilip MatthijssensBéatrice LintermansTim PietersNiels VandammeWouter Van LoockeGeert BerxBruce PoppeJean-Pierre BourquinPieter Van Vlierberghe

The combination of ABT-199 and JQ1 as a novel therapeutic strategy in T-cell acute lymphoblastic leukemia

Sofie PeirsFilip MatthijssensTim PietersNiels VandammeBéatrice LintermansLindy ReunesGeert BerxBruce PoppePieter Van Vlierberghe

2015

Epigenetics in T-cell acute lymphoblastic leukemia

Sofie PeirsJoni Van der MeulenInge Van de WalleTom TaghonFranki SpelemanBruce PoppePieter Van Vlierberghe

A1 Journal Article in IMMUNOLOGICAL REVIEWS

Novel biological insights in T-cell acute lymphoblastic leukemia

Kaat DurinckSteven GoossensSofie PeirsAnnelynn WallaertWouter Van LoockeFilip MatthijssensTim PietersGloria MilaniTim LammensPieter RondouNadine Van RoyBarbara De MoerlooseYves BenoitJody HaighFranki SpelemanBruce PoppePieter Van Vlierberghe

A1 Journal Article in EXPERIMENTAL HEMATOLOGY

ZEB2 drives immature T-cell lymphoblastic leukaemia development via enhanced tumour-initiating potential and IL-7 receptor signalling

Steven GoossensEnrico RadaelliOdile BlanchetKaat DurinckJoni Van der MeulenSofie PeirsTom TaghonCedric S TremblayMagdaline CostaMorvarid Farhang GhahremaniJelle De MedtsSona BartunkovaKatharina HaighClaire SchwabNatalie FarlaTim PietersFilip MatthijssensNadine Van RoyJ Adam BestKim DeswartePieter BogaertCatherine CarmichaelAdam RickardSanti SuryaniLauryn S BrackenRaed AlserihiKirsten Cante-BarretLieven HaenebalckeEmmanuelle ClappierPieter RondouKarolina SlowickaDanny HuylebroeckAnanda W GoldrathViktor JanzenMatthew P McCormackRichard B LockDavid J CurtisChristine HarrisonGeert BerxFranki SpelemanJules PP MeijerinkJean SoulierPieter Van VlierbergheJody Haigh

A1 Journal Article in NATURE COMMUNICATIONS

2014

ABT-199 mediated inhibition of BCL-2 as a novel therapeutic strategy in T-cell acute lymphoblastic leukemia

Sofie PeirsFilip MatthijssensSteven GoossensInge Van de WalleKatia RuggeroCharles E de BockSandrine DegryseKirsten Canté-BarrettDelphine BriotEmmanuelle ClappierTim LammensBarbara De MoerlooseYves BenoitBruce PoppeJules P MeijerinkJan CoolsJean SoulierTerence H RabbittsTom TaghonFranki SpelemanPieter Van Vlierberghe

A1 Journal Article in BLOOD

ABT-199 mediated inhibition of BCL-2 as a novel therapeutic strategy in early immature T-cell acute lymphoblastic leukemia

Sofie PeirsFilip MatthijssensSteven GoossensKirsten Canté-BarrettTim LammensBarbara De MoerlooseYves BenoitJean SoulierBruce PoppeTom TaghonJules MeijerinkFranki SpelemanPieter Van Vlierberghe

ABT-199 mediated inhibition of BCL2 as a novel therapeutic strategy in T-cell acute lymphoblastic leukemia

Sofie PeirsFilip MatthijssensSteven GoossensCharles De BockKirsten Canté-BarrettTim LammensInge Van de WalleBarbara De MoerlooseYves BenoitBruce PoppeTom TaghonJan CoolsJules MeijerinkJean SoulierFranki SpelemanPieter Van Vlierberghe