Research Explorer

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Researcher

Sofie Lust

Awards & Distinctions

21 Results

2016

Mimicking the tumour microenvironment of chronic lymphocytic leukaemia in vitro critically depends on the type of B-cell receptor stimulation

Ans RomboutSofie LustFritz OffnerEvelien NaessensBruno VerhasseltJan Philippé

A1 Journal Article in BRITISH JOURNAL OF CANCER

2015

Lipoprotein lipase SNPs rs13702 and rs301 correlate with clinical outcome in chronic lymphocytic leukemia patients

Ans RomboutBasile StamatopoulosLaurence LagneauxSofie LustFritz OffnerEvelien NaessensHanne VanderstraetenBruno VerhasseltJan Philippé

A1 Journal Article in PLOS ONE

Mimicking the tumor microenvironment of chronic lymphocytic leukemia in vitro critically depends on the type of B cell receptor stimulation

Ans RomboutSofie LustFritz OffnerEvelien NaessensBruno VerhasseltJan Philippé

2013

ER stress in diffuse large B cell lymphoma: GRP94 is a possible biomarker in germinal center versus activated B-cell type

Jerina BoelensJean-Philippe JaisBarbara VanhoeckeIlse BeckHeleen Van MelckebekeJan PhilippéMarc BrackeFabrice JardinJosette BrièreKaren Leroy et al.

A1 Journal Article in LEUKEMIA RESEARCH

2011

Identification of an Ire1alpha endonuclease specific inhibitor with cytotoxic activity against human multiple myeloma

Ioanna PapandreouNicholas C DenkoMichael OlsonHeleen Van MelckebekeSofie LustArvin TamDavid E Solow-CorderoDonna M BouleyFritz OffnerMaho Niwa et al.

A1 Journal Article in BLOOD

2010

Characterization of the unfolded protein response by pharmacological agents in lymphoid malignancies

Sofie LustFritz OffnerMarc Bracke

The flavonoid tangeretin activates the unfolded protein response and synergizes with imatinib in the erythroleukemia cell line K562

Sofie LustBarbara VanhoeckeMireille Van GeleJan PhilippéMarc BrackeFritz Offner

A1 Journal Article in MOLECULAR NUTRITION & FOOD RESEARCH

2009

Chronic Lymphocytic Leukaemia

Jerina BoelensSofie LustBarbara VanhoeckeFritz Offner

A1 Journal Article in ANTICANCER RESEARCH

Steroid effects on ZAP-70 and SYK in relation to apoptosis in poor prognosis chronic lymphocytic leukemia

Jerina BoelensSofie LustFEMKE VAN BOCKSTAELEMireille Van GeleAnn JanssensLara DeryckeBarbara VanhoeckeJan PhilippéMarc BrackeFritz Offner

A1 Journal Article in LEUKEMIA RESEARCH

Xanthohumol activates the proapoptotic arm of the unfolded protein response in chronic lymphocytic leukemia

Sofie LustBarbara VanhoeckeMireille Van GeleJerina BoelensHeleen Van MelckebekeMary KailehWim Vanden BergheGuy HaegemanJan PhilippéMarc Bracke et al.

A1 Journal Article in ANTICANCER RESEARCH

2008

The microbial PhIP metabolite 7-hydroxy-5-methyl-3-phenyl-6,7,8,9-tetrahydropyrido[3 ',2 ': 4,5]imidazo[1,2-a]pyrimidin-5-ium chloride (PhIP-M1) induces DNA damage, apoptosis and cell cycle arrest towards Caco-2 cells

Lynn VanhaeckeLara DeryckeF LE CURIEUXSofie LustD MARZINWilly VerstraeteMarc Bracke

A1 Journal Article in TOXICOLOGY LETTERS

The prenylated chalcone xanthohumol induces unfolded protein response, autophagy, and cell death in breast cancer cells by proteasome inhibition

Barbara VanhoeckeMireille Van GeleWim MartinetAnne-Sophie Vercoutter-EdouartSofie LustDelphine DebruyneDenis De KeukeleireFritz Offnermarc bracke

2007

Methylprednisolone downregulates ZAP-70 expression in B-CLL cells in vitro

Jerina BoelensSofie LustAnn JanssensJan PhilippéFritz Offner

The anti-invasive and proapoptotic effect of xanthohumol: potential use in cancer.

Barbara VanhoeckeJerina BoelensSofie LustFritz Offnermarc bracke

Bookchapter in Beer in Health and Desease Prevention

The endoplasmic reticulum: A target for new anticancer drugs

Jerina BoelensSofie LustFritz Offnermarc brackeBarbara Vanhoecke

A1 Journal Article in IN VIVO

Xanthohumol induces in vitro apoptosis in B-CLL cells mediated by non-classical ER stress

Sofie LustBarbara VanhoeckeMireille Van GeleJerina BoelensMary KailehWim Vanden BergheJ PHILLIPESmarc brackeFritz Offner

Xanthohumol: a new potential proteasome inhibitor that activates the pro-apoptotic arm of the unfolded protein response in B-CLL cells

Sofie LustBarbara VanhoeckeMireille Van GeleJerina BoelensJan PhilippéPetra Vinckenmarc brackeMartine PoelmanFritz Offner

2005

Xanthohumol induces apoptosis in B-CLL mediated by caspase 9 following downregulation of bcL-xL and mcl-1

Barbara VanhoeckeSofie LustAnne JanssensJan Philippémarc brackeFritz Offner

Xanthohumol kills B-chronic lymphocytic leukemia cells by an apoptotic mechanism

Sofie LustBarbara VanhoeckeAnne JanssensJan Philippémarc brackeFritz Offner

A1 Journal Article in MOLECULAR NUTRITION & FOOD RESEARCH

2004

CXCL-12 induces prolonged erk-phosphorylation in Zap-70 positive B-CLL

Sofie LustJerina BoelensANN JANSSENSJan Philippémarc brackeFritz Offner

Tangeretin synergizes with imatinib in inhibiting growth of bcr-abl positive K562 Erythroleukemia cells in an Erk-dependent way

Sofie LustBarbara Vanhoeckemarc brackeFritz Offner