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Researcher
Simon Van Herck
Profile
Projects
Publications
Activities
Awards & Distinctions
31
Results
2024
Thermosensitive polymer prodrug nanoparticles prepared by an all-aqueous nanoprecipitation process and application to combination therapy
Léa Guerassimoff
Marianne Ferrere
Simon Van Herck
Samy Dehissi
Valérie Nicolas
Bruno De Geest
Julien Nicolas
A1
Journal Article
in
JOURNAL OF CONTROLLED RELEASE
2024
2023
Lipid nanoparticle delivery alters the adjuvanticity of the TLR9 agonist CpG by innate immune activation in lymphoid tissue
Zifu Zhong
Yong Chen
Kim Deswarte
Heleen Lauwers
Emily De Lombaerde
Xiaole Cui
Simon Van Herck
Tingting Ye
Mark Gontsarik
Stefan Lienenklaus
et al.
A1
Journal Article
in
ADVANCED HEALTHCARE MATERIALS
2023
Smart hydrogels delivered by high pressure aerosolization can prevent peritoneal adhesions
Helena Braet
Peter-Paul Fransen
Yong Chen
Simon Van Herck
Remco Mariën
Valérie Vanhoorne
Wim Ceelen
Annemieke Madder
Steven Ballet
Richard Hoogenboom
et al.
A1
Journal Article
in
JOURNAL OF CONTROLLED RELEASE
2023
2022
In situ tumor vaccination with calcium‐linked degradable coacervate nanocomplex co‐delivering photosensitizer and TLR7/8 agonist to trigger effective anti‐tumor immune responses
Yutong Liu
Hui Li
Huajun Zhao
Yanyun Hao
Simon Van Herck
Zejun Xu
Guan Wang
Xiao Wang
Xinke Zhang
Xiaoyan Ge
et al.
A1
Journal Article
in
ADVANCED HEALTHCARE MATERIALS
2022
2021
A manganese phosphate nanocluster activates the cGAS‐STING pathway for enhanced cancer immunotherapy
Min Gao
Yu‐Qing Xie
Kewen Lei
Yu Zhao
Armand Kurum
Simon Van Herck
Yugang Guo
Xiaomeng Hu
Li Tang
A1
Journal Article
in
ADVANCED THERAPEUTICS
2021
Delivery of STING agonists for adjuvanting subunit vaccines
Simon Van Herck
Bing Feng
Li Tang
A1
Journal Article
in
ADVANCED DRUG DELIVERY REVIEWS
2021
Lipid nature and alkyl length influence lymph node accumulation of lipid-polyethylene glycol amphiphiles
Jana De Vrieze
Antonio Pires da Silva Baptista
Lutz Nuhn
Simon Van Herck
Kim Deswarte
Haijun Yu
Bart Lambrecht
Bruno De Geest
A1
Journal Article
in
ADVANCED THERAPEUTICS
2021
Lipid-polyglutamate nanoparticle vaccine platform
Dorien Van Lysebetten
Alessio Malfanti
Kim Deswarte
Kaloian Koynov
Bianka Golba
Tingting Ye
Zifu Zhong
Sabah Kasmi
Alexander Lamoot
Yong Chen
et al.
A1
Journal Article
in
ACS APPLIED MATERIALS & INTERFACES
2021
Sterilizing immunity against SARS‐CoV‐2 infection in mice by a single‐shot and lipid amphiphile imidazoquinoline TLR7/8 agonist‐adjuvanted recombinant spike protein vaccine**
Sonia Jangra
Jana De Vrieze
Angela Choi
Raveen Rathnasinghe
Gabriel Laghlali
Annemiek Uvyn
Simon Van Herck
Lutz Nuhn
Kim Deswarte
Zifu Zhong
et al.
A1
Journal Article
in
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
2021
Switchable immune modulator for tumor-specific activation of anticancer immunity
Yu Zhao
Yu-Qing Xie
Simon Van Herck
Sina Nassiri
Min Gao
Yugang Guo
Li Tang
A1
Journal Article
in
SCIENCE ADVANCES
2021
2020
Design of pH-degradable polymer-lipid amphiphiles using a ketal-functionalized RAFT chain transfer agent
Jana De Vrieze
Simon Van Herck
Lutz Nuhn
Bruno De Geest
A1
Journal Article
in
MACROMOLECULAR RAPID COMMUNICATIONS
2020
Imidazoquinoline-conjugated degradable coacervate conjugate for local cancer immunotherapy
Hui Li
Simon Van Herck
Yongjun Liu
Yanyun Hao
Xiaochu Ding
Lutz Nuhn
Zifu Zhong
Francis Combes
Niek Sanders
Stefan Lienenklaus
et al.
A1
Journal Article
in
ACS BIOMATERIALS SCIENCE & ENGINEERING
2020
Nanomedicine-mediated alteration of the pharmacokinetic profile of small molecule cancer immunotherapeutics
Simon Van Herck
Bruno De Geest
A1
Journal Article
in
ACTA PHARMACOLOGICA SINICA
2020
Potent and prolonged innate immune activation by enzyme-responsive imidazoquinoline TLR7/8 agonist prodrug vesicles
Bi Wang
Simon Van Herck
Yong Chen
Xiangyang Bai
Zifu Zhong
Kim Deswarte
Bart Lambrecht
Niek Sanders
Stefan Lienenklaus
Hans W. Scheeren
et al.
A1
Journal Article
in
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
2020
Sterilizing immunity against SARS-CoV-2 infection in mice by a single-shot and modified imidazoquinoline TLR7/8 agonist-adjuvanted recombinant spike protein vaccine
Sonia Jangra
Jana De Vrieze
Angela Choi
Raveen Rathnasinghe
Gabriel Laghlali
Annemiek Uvyn
Simon Van Herck
Lutz Nuhn
Kim Deswarte
Zifu Zhong
et al.
Preprint
2020
Zebrafish embryos allow prediction of nanoparticle circulation times in mice and facilitate quantification of nanoparticle-cell interactions
Nils-Jorgen Knudsen Dal
Agnese Kocere
Jens Wohlmann
Simon Van Herck
Tobias A. Bauer
Julien Resseguier
Shahla Bagherifam
Hilde Hyldmo
Matthias Barz
Bruno De Geest
et al.
A1
Journal Article
in
SMALL
2020
2019
A synthetic, transiently thermoresponsive homopolymer with UCST behaviour within a physiologically relevant window
Zhiyue Zhang
Hui Li
Sabah Kasmi
Simon Van Herck
Kim Deswarte
Bart Lambrecht
Richard Hoogenboom
Lutz Nuhn
Bruno De Geest
A1
Journal Article
in
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
2019
Interactive polymers for innate immune activation
Simon Van Herck
Bruno De Geest
Dissertation
2019
Potent Lymphatic Translocation and Spatial Control Over Innate Immune Activation by Polymer-Lipid Amphiphile Conjugates of Small-Molecule TLR7/8 Agonists
Jana De Vrieze
Benoit Louage
Kim Deswarte
Zifu Zhong
Ruben De Coen
Simon Van Herck
Lutz Nuhn
Camilla Kaas Frich
Alexander N Zelikin
Stefan Lienenklaus
et al.
A1
Journal Article
in
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
2019
Water-soluble Withaferin A polymer prodrugs via a drug-functionalized RAFT CTA approach
Simon Van Herck
Behrouz Hassannia
Benoit Louage
Raquel Pita Compostizo
Ruben De Coen
Wim Vanden Berghe
Tom Vanden Berghe
Bruno De Geest
A1
Journal Article
in
EUROPEAN POLYMER JOURNAL
2019
2018
A versatile method for the selective core-crosslinking of hyaluronic acid nanogels via ketone-hydrazide chemistry : from chemical characterization to in vivo biodistribution
Francielle Pelegrin Garcia
Marlène Rippe
Mychelle VP Companhoni
Talitha Fernandes Stefanello
Benoit Louage
Simon Van Herck
Lucie Sancey
Jean-Luc Coll
Bruno De Geest
Celso Vataru Nakamura
et al.
A2
Journal Article
in
BIOMATERIALS SCIENCE
2018
Enhanced permeability and retention-like extravasation of nanoparticles from the vasculature into tuberculosis granulomas in zebrafish and mouse models
Federico Fenaroli
Urska Repnik
Yitian Xu
Kerstin Johann
Simon Van Herck
Pradip Dey
Frode Miltzov Skjeldal
Dominik M Frei
Shahla Bagherifam
Agnese Kocere
et al.
A1
Journal Article
in
ACS NANO
2018
FRET monitoring of intracellular ketal hydrolysis in synthetic nanoparticles
Lutz Nuhn
Simon Van Herck
Andreas Best
Kim Deswarte
Maria Kokkinopoulou
Ingo Lieberwirth
Kaloian Koynov
Bart Lambrecht
Bruno De Geest
A1
Journal Article
in
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
2018
Lymph-node-targeted immune activation by engineered block copolymer amphiphiles-TLR7/8 agonist conjugates
Simon Van Herck
Kim Deswarte
Lutz Nuhn
Zifu Zhong
João Portela Catani
Yupeng Li
Niek Sanders
Stefan Lienenklaus
Stefaan De Koker
Bart Lambrecht
et al.
A1
Journal Article
in
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
2018
Nano-targeted induction of dual ferroptotic mechanisms eradicates high-risk neuroblastoma
Behrouz Hassannia
Bartosz Wiernicki
Irina Ingold
Feng Qu
Simon Van Herck
Yulia Y. Tyurina
Hülya Bayır
Behnaz A. Abhari
Jose Pedro Friedmann Angeli
Sze Men Choi
et al.
A1
Journal Article
in
JOURNAL OF CLINICAL INVESTIGATION
2018
The relevance of shear, sedimentation and diffusion during spin freezing, as potential first step of a continuous freeze-drying process for unit doses
Joris Lammens
Séverine Mortier
Laurens De Meyer
Brecht Vanbillemont
Pieter-Jan Van Bockstal
Simon Van Herck
Jos Corver
Ingmar Nopens
Valérie Vanhoorne
Bruno De Geest
et al.
A1
Journal Article
in
INTERNATIONAL JOURNAL OF PHARMACEUTICS
2018
Transiently thermoresponsive acetal polymers for safe and effective administration of Amphotericin B as a vaccine adjuvant
Simon Van Herck
Lien Van Hoecke
Benoit Louage
Lien Lybaert
Ruben De Coen
Sabah Kasmi
Aaron P Esser-Kahn
Sunil A David
Lutz Nuhn
Bert Schepens
et al.
A1
Journal Article
in
BIOCONJUGATE CHEMISTRY
2018
pH-Sensitive hydrazone-linked doxorubicin nanogels via polymeric-activated ester scaffolds : synthesis, assembly, and in vitro and in vivo evaluation in tumor-bearing zebrafish
Alexandra Van Driessche
Agnese Kocere
Hannelien Everaert
Lutz Nuhn
Simon Van Herck
Gareth Griffiths
Federico Fenaroli
Bruno De Geest
A1
Journal Article
in
CHEMISTRY OF MATERIALS
2018
2017
Acrylamides with hydrolytically labile carbonate ester side chains as versatile building blocks for well-defined block copolymer micelles via RAFT polymerization
Sabah Kasmi
Benoit Louage
Lutz Nuhn
Glenn Verstraete
Simon Van Herck
Mies J van Steenbergen
Chris Vervaet
Wim E Hennink
Bruno De Geest
A1
Journal Article
in
POLYMER CHEMISTRY
2017
Downstream processing from hot-melt extrusion towards tablets : a quality by design approach
Wouter Grymonpré
Nils Bostijn
Simon Van Herck
Glenn Verstraete
Valérie Vanhoorne
Lutz Nuhn
Pieter Rombouts
Thomas De Beer
Jean Paul Remon
Chris Vervaet
A1
Journal Article
in
INTERNATIONAL JOURNAL OF PHARMACEUTICS
2017
Uptake of long protein-polyelectrolyte nanotubes by dendritic cells
Diana G Ramírez-Wong
Saghi Saghazadeh
Simon Van Herck
Bruno De Geest
Alain M Jonas
Sophie Demoustier-Champagne
A1
Journal Article
in
BIOMACROMOLECULES
2017