Research Explorer

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Researcher

Simon Tavernier

Awards & Distinctions

55 Results

2023

A Complement Atlas identifies interleukin 6 dependent alternative pathway dysregulation as a key druggable feature of COVID-19

Karel Van DammeLevi HosteJozefien DeclercqElisabeth De LeeuwBastiaan MaesLiesbet MartensRoos ColmanRobin BrowaeysCédric BosteelsStijn Verwaerde et al.

Exploring the immune horizon : systemic inflammatory diseases in the era of SARS-CoV-2 and beyond

Levi HosteFilomeen HaerynckJo DehoorneSimon Tavernier

Innate immune sensors balance infection surveillance and autoinflammation

Leslie NaesensFilomeen HaerynckTessa KerreSimon Tavernier

LXR signaling controls homeostatic dendritic cell maturation

Victor BosteelsSandra MaréchalClint De NolfSofie RennenJonathan MaelfaitSimon TavernierJessica VettersEvelien Van De VeldeFarzaneh FayazpourKim Deswarte et al.

A1 Journal Article in SCIENCE IMMUNOLOGY

Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19

Daniela MatuozzoEstelle TalouarnAstrid MarchalPeng ZhangJeremy ManryYoann SeeleuthnerYu ZhangAlexandre BolzeMatthieu ChaldebasBaptiste Milisavljevic et al.

A1 Journal Article in GENOME MEDICINE

2022

Efficacy and safety of the investigational complement C5 inhibitor zilucoplan in patients hospitalized with COVID-19 : an open-label randomized controlled trial

Elisabeth De LeeuwKarel Van DammeJozefien DeclercqCédric BosteelsBastiaan MaesSimon TavernierLaurent DetalleTrevor SmartSophie GlattNincy Debeuf et al.

A1 Journal Article in RESPIRATORY RESEARCH

GTF3A mutations predispose to herpes simplex encephalitis by disrupting biogenesis of the host-derived RIG-I ligand RNA5SP141

Leslie NaesensSantoshi MuppalaDhiraj AcharyaJosephine NemegeerDelfien BogaertJung-Hyun LeeKatrien StaesVeronique DebackerPieter De BleserMarieke De Bruyne et al.

A1 Journal Article in SCIENCE IMMUNOLOGY

Loss of GM-CSF-dependent instruction of alveolar macrophages in COVID-19 provides a rationale for inhaled GM-CSF treatment

Cédric BosteelsKarel Van DammeElisabeth De LeeuwJozefien DeclercqBastiaan MaesVictor BosteelsLevi HosteLeslie NaesensNincy DebeufJulie Deckers et al.

A1 Journal Article in CELL REPORTS MEDICINE

Mutations in RNU7-1 weaken secondary RNA structure, induce MCP-1 and CXCL10 in CSF, and result in Aicardi-Goutières syndrome with severe end-organ involvement

Leslie NaesensJosephine NemegeerFilip RoelensLore VallaeysMarije MeuwissenKatrien JanssensPATRICK VERLOOBenson OgunjimiDimitri HemelsoetLevi Hoste et al.

A1 Journal Article in JOURNAL OF CLINICAL IMMUNOLOGY

Role of integrin expression in the prediction of response to vedolizumab : a prospective real‐life multicentre cohort study

Cara De GalanBryan GonzalesSophie Van WeldenSimon TavernierTriana Lobatón OrtegaWouter Van MoerkerckeBeatrijs StrubbeHarald PeetersElisabeth MackenMartine De Vos et al.

A1 Journal Article in CLINICAL AND TRANSLATIONAL MEDICINE

TIM3+ TRBV11-2 T cells and IFNγ signature in patrolling monocytes and CD16+ NK cells delineate MIS-C

Levi HosteLisa RoelsLeslie NaesensVictor BosteelsStijn VanheeSam DupontCédric BosteelsRobin BrowaeysNiels VandammeKevin Verstaen et al.

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

2021

Clinical, genetic and immunological evaluation of the type I interferonopathy Aicardi-Goutieres syndrome caused by mutations in RNU7-1

Leslie NaesensJosephine NemegeerTessa KerreRudi BeyaertSimon TavernierJonathan MaelfaitFilomeen Haerynck

Early prediction of response to vedolizumab in patients with active inflammatory bowel disease : a prospective real-life multicentre cohort study

Cara De GalanGerard Bryan GonzalesSophie Van WeldenSimon TavernierTriana Lobatón OrtegaWouter Van MoerkerckeBeatrijs StrubbeHarald PeetersElisabeth MackenMartine De Vos et al.

GTF3A mutations in a patient with herpes simplex encephalitis reveals a novel role in viral immunity by transcribing 5S rRNA pseudogenes serving as RIG-I ligands

Leslie NaesensSantoshi MuppalaJung-Hyun LeeJosephine NemegeerDhiraj AcharyaDelfien BogaertMichiel van GentJens StaalKatrien StaesVeronique Debacker et al.

Immune monitoring in melanoma and urothelial cancer patients treated with anti-PD-1 immunotherapy and SBRT discloses tumor specific immune signatures

Annabel MeiresonSimon TavernierSofie Van GassenNora SundahlAnnelies DemeyerMathieu SpaasVibeke KruseLiesbeth FerdinandeJo Van DorpeBenjamin Hennart et al.

A1 Journal Article in CANCERS

Individuals with NR5A1 (SF1) mutations and atypical sex development and their asymptomatic family member carriers are at high risk of hyposplenism

Celien GrijpSimon TavernierJana NeirinckMaha Abdullhadi-AtwanJulie Van De VeldeDorien BaetensHannah VerdinLieve MorbéeElfride De BaereDavid Zangen et al.

Integration of genomics and transcriptomics allows the identification of rare DNA damage defects in PID patients with a cancer predisposition

Lynn BackersBram PartonMattias Van HeetveldeMarieke De BruyneKim De LeeneerSimon TavernierAnne VralFilomeen HaerynckKathleen Claes

Intestinal cDC1 drive cross-tolerance to epithelial-derived antigen via induction of FoxP3(+) CD8(+) T-regs

Thorsten JoerisCristina Gomez-CasadoPetra HolmkvistSimon TavernierAaron Silva-SanchezLuisa KlotzTroy D. RandallAllan M. MowatKnut KotarskyBernard Malissen et al.

A1 Journal Article in SCIENCE IMMUNOLOGY

Missing heritability in Bloom syndrome : First report of a deep-intronic variant leading to pseudo-exon activation in the BLM gene

Lynn BackersBram PartonMarieke De BruyneSimon TavernierKris Van Den BogaertBart LambrechtFilomeen HaerynckKathleen Claes

Missing heritability in Bloom syndrome : first report of a deep intronic variant leading to pseudo‐exon activation in the BLM gene

Lynn BackersBram PartonMarieke De BruyneSimon TavernierKris Van Den BogaertBart LambrechtFilomeen HaerynckKathleen Claes

A1 Journal Article in CLINICAL GENETICS

Novel mutations in RNU7-1 weaken secondary RNA structure, induce MCP-1 and CXCL10 in CSF and result in Aicardi-Goutières syndrome with severe end-organ involvement

Leslie NaesensJosephine NemegeerFilip RoelensLore VallaeysMarije MeuwissenKatrien JanssensPATRICK VERLOOBenson OgunjimiDimitri HemelsoetProgram for Undiagnosed Rare Diseases (UD-PrOZA) et al.

X-linked recessive TLR7 deficiency in ~1% of men under 60 years old with life-threatening COVID-19

Takaki AsanoBertrand BoissonFanny OnodiDaniela MatuozzoMarcela Moncada-VelezMajistor Raj Luxman Maglorius RenkilarajPeng ZhangLaurent MeertensAlexandre BolzeMarie Materna et al.

A1 Journal Article in SCIENCE IMMUNOLOGY

‘Nieuwe heren, nieuwe wetten’ : identificatie van een nieuw pediatrisch inflammatoir syndroom in het midden van de SARS-CoV-2-pandemie

Levi HosteSimon TavernierFilomeen Haerynck

A4 Journal Article in PERCENTIEL (NEDERLANDSE ED.)

2020

Case report : convalescent plasma, a targeted therapy for patients with CVID and severe COVID-19

Karel Van DammeSimon TavernierNele Van RoyElisabeth De LeeuwJozefien DeclercqCédric BosteelsBastiaan MaesMarieke De BruyneDelfien BogaertVictor Bosteels et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Cytokine profiling by multiplex immunoassay as a valuable tool for diagnosis and monitoring patients with autoinflammatory disorders

Levi HosteJo DehoornePeggy JacquesSteven CallensJeroen van der HilstVito SabatoBenson OgunjimiSimon TavernierFilomeen Haerynck

Dominant-negative mutations in human IL6ST underlie hyper-IgE syndrome

Vivien BéziatSimon TavernierYin-Huai ChenCindy S. MaMarie MaternaArian LaurenceJens StaalDominik AschenbrennerLisa RoelsLisa Worley et al.

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

First patient with bloom syndrome caused by a deep intronic variant leading to pseudoexon activation

Lynn BackersBram PartonStephanie VermeulenMarieke De BruyneKris Van Den BogaertAnne VralAns BaeyensSimon TavernierFilomeen HaerynckKathleen Claes

First patient with bloom syndrome caused by a deep intronic variant leading to pseudoexon activation

Lynn BackersBram PartonStephanie VermeulenMarieke De BruyneSimon TavernierKris Van Den BogaertAnne VralAns BaeyensFilomeen HaerynckBart Lambrecht et al.

GATA2 deficiency and haematopoietic stem cell transplantation : challenges for the clinical practitioner

Delfien BogaertGenevieve LaureysLeslie NaesensDominiek MazureMarieke De BruyneAmy P. HsuVictoria Bordon MariaErik WoutersSimon TavernierBart Lambrecht et al.

A1 Journal Article in BRITISH JOURNAL OF HAEMATOLOGY

Inborn errors of type I IFN immunity in patients with life-threatening COVID-19

Qian ZhangPaul BastardZhiyong LiuJérémie Le PenMarcela Moncada-VelezJie ChenMasato OgishiIra K. D. SabliStephanie HodeibCecilia Korol et al.

A1 Journal Article in SCIENCE

Integrin expression changes on the T cells subsets influence the response to vedolizumab in inflammatory bowel disease patients

Cara De GalanSophie Van WeldenSimon BosSimon TavernierTriana Lobatón OrtegaBryan GonzalesWouter Van MoerkerckeBeatrijs StrubbeHarald PeetersElisabeth Macken et al.

Missing heritability in Bloom syndrome : first report of a deep-intronic variant leading to pseudo-exon activation in the BLM gene

Lynn BackersBram PartonMarieke De BruyneSimon TavernierKris Van Den BogaertBart LambrechtFilomeen HaerynckKathleen Claes

cDNA and targeted RNA sequencing to unravel hidden genetic defects in PID patients with only one-disease related variant in genes with recessive inheritance

Lynn BackersMarieke De BruyneSimon TavernierFilomeen HaerynckKathleen Claes

2019

A computational pipeline for the diagnosis of CVID patients

Annelies EmmaneelDelfien BogaertSofie Van GassenSimon TavernierMelissa DullaersFilomeen HaerynckYvan Saeys

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

A human immune dysregulation syndrome characterized by severe hyperinflammation with a homozygous nonsense Roquin-1 mutation

Simon TavernierV AthanasopoulosPATRICK VERLOOG BehrensJens StaalDelfien BogaertLeslie NaesensMarieke De BruyneSofie Van GassenEef Parthoens et al.

A1 Journal Article in NATURE COMMUNICATIONS

GATA2 deficiency and hematopoietic stem cell transplantation : challenges for the clinical practitioner

Delfien BogaertLeslie NaesensGenevieve LaureysVictoria Bordon MariaErik WoutersSimon TavernierBart LambrechtFilomeen HaerynckTessa Kerre

Homozygous NLRP1 gain-of-function mutation in siblings with a syndromic form of recurrent respiratory papillomatosis

Scott B DrutmanFilomeen HaerynckFranklin L ZhongDavid HumNicholas J HernandezSerkan BelkayaFranck RapaportSarah Jill de JongDavid CreytensSimon Tavernier et al.

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Integrin expression changes on the T cell subsets influence the response to vedolizumab in inflammatory bowel disease patients

Cara De GalanSophie Van WeldenSimon BosSimon TavernierTriana Lobatón OrtegaBryan GonzalesWouter Van MoerkerckeBeatrijs StrubbeHarald PeetersElisabeth Macken et al.

Metabolic and innate immune cues merge into a specific inflammatory response via the UPR

Denis A MogilenkoJoel T HaasLaurent L’hommeSébastien FleurySandrine QuemenerMatthieu LevavasseurCoralie BecquartJulien WartelleAlexandra BogomolovaLaurent Pineau et al.

A1 Journal Article in CELL

Pitfalls in diagnosing complement factor I deficiencies : from clinical phenotype to laboratory diagnosis

Leslie NaesensJulie SmetSimon TavernierStijn LambrechtTessa KerreJohan Van de WalleLubka RoumeninaPatrick StordeurFilomeen Haerynck

The ubiquitin-editing enzyme A20 controls NK cell homeostasis through regulation of mTOR activity and TNF

Jessica VettersMary van HeldenSigrid WahlenSimon TavernierArne MartensFarzaneh FayazpourKarl VergoteManon VanheerswynghelsKim DeswarteJustine Van Moorleghem et al.

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

cDNA and targeted RNA sequencing to unravel hidden genetic defects in PID patients with only one-disease related variant in genes with recessive inheritance

Lynn BackersMarieke De BruyneSimon TavernierFilomeen HaerynckKathleen Claes

2018

A CARD9 founder mutation disrupts NF-κB signaling by inhibiting BCL10 and MALT1 recruitment and signalosome formation

Marieke De BruyneLevi HosteDelfien BogaertLien Van den BosscheSimon TavernierEef ParthoensMélanie MigaudDeborah KonopnickiJean Cyr YombiBart Lambrecht et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

A novel LPS-responsive beige-like anchor protein (LRBA) mutation presents with normal cytotoxic T lymphocyte-associated protein 4 (CTLA-4) and overactive TH17 immunity

Marieke De BruyneDelfien BogaertKoen VenkenLien Van den BosscheCarolien BonroyLisa RoelsSimon TavernierEls van de VijverAnn DriessenMarielle van Gijn et al.

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Stabilization of cytokine mRNAs in iNKT cells requires the serine-threonine kinase IRE1alpha

Srinath GovindarajanDjoere GaublommeRenée Van der CruyssenEveline VerheugenSofie Van GassenYvan SaeysSimon TavernierTakao IwawakiYehudi BlochSavvas Savvides et al.

A1 Journal Article in NATURE COMMUNICATIONS

The complex differential diagnosis underlying fungal infections : a clinical practice guideline regarding persistent, recurrent or invasive candidiasis

Levi HosteDelfien BogaertMarieke De BruyneVictoria Bordon MariaPetra SchelstraeteCarolien BonroySimon TavernierFilomeen Haerynck

The unfolded protein response in the immune cell development : putting the caretaker in the driving seat

Simon TavernierBart LambrechtSophie Janssens

A1 Journal Article in CURRENT TOPICS IN MICROBIOLOGY AND IMMUNOLOGY

2017

Dendritic cells under stress : on the role of the unfolded protein response and hypoxia signaling

Simon TavernierSophie JanssensBart Lambrecht

Haematopoietic prolyl hydroxylase-1 deficiency promotes M2 macrophage polarization and is both necessary and sufficient to protect against experimental colitis

Sophie Van WeldenMartine De VosBen WielockxSimon TavernierMelissa DullaersSara NeytBenedicte DescampsLindsey DevisscherSarah DevrieseLien Van den Bossche et al.

A1 Journal Article in JOURNAL OF PATHOLOGY

Opposing regulation and roles for PHD3 in lung dendritic cells and alveolar macrophages

Simon TavernierNele VanlangenakkerJessica VettersPeter CarmelietSophie JanssensBart Lambrecht

A1 Journal Article in JOURNAL OF LEUKOCYTE BIOLOGY

Regulated IRE1-dependent mRNA decay sets the threshold for dendritic cell survival

Simon TavernierFabiola OsorioLana VandersarrenJessica VettersNele VanlangenakkerGert Van IsterdaelKarl VergoteRiet De RyckeEef ParthoensLianne van de Laar et al.

A1 Journal Article in NATURE CELL BIOLOGY

2016

Isolation of conventional dendritic cells from mouse lungs

Lianne van de LaarMartin GuilliamsSimon Tavernier

Bookchapter in Dendritic cell protocols

Unsupervised high-dimensional analysis aligns dendritic cells across tissues and species

Martin GuilliamsCharles-Antoine DutertreCharlotte ScottNaomi McGovernDorine SichienSvetoslav ChakarovSofie Van GassenJinmiao ChenMichael PoidingerSofie De Prijck et al.

A1 Journal Article in IMMUNITY

2014

The unfolded-protein-response sensor IRE-1α regulates the function of CD8α⁺ dendritic cells

Fabiola OsorioSimon TavernierEik HoffmannYvan SaeysLiesbet MartensJessica VettersIris DelrueRiet De RyckeEef ParthoensPhilippe Pouliot et al.

A1 Journal Article in NATURE IMMUNOLOGY

2010

Geneesmiddelen en ontwikkelingslanden

REBECCA STAELSimon TavernierFilip ViaeneML DelfosseMarcus BogaertJan De Maeseneer

A2 Journal Article in TIJDSCHRIFT VOOR GENEESKUNDE