Research Explorer

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Researcher

Simon Tavernier

41 Results

2021

Early prediction of response to vedolizumab in patients with active inflammatory bowel disease : a prospective real-life multicentre cohort study

Cara De GalanGerard Bryan GonzalesSophie Van WeldenSimon TavernierTriana Lobatón OrtegaWouter Van MoerkerckeBeatrijs StrubbeHarald PeetersElisabeth MackenMartine De VosDebby LaukensPieter Hindryckx

Effect of anti-interleukin drugs in patients with COVID-19 and signs of cytokine release syndrome (COV-AID) : a factorial, randomised, controlled trial

Jozefien DeclercqKarel Van DammeElisabeth De LeeuwBastiaan MaesCedric BosteelsSimon TavernierStefanie De BuyserRoos ColmanMaya HitesGil VerscheldenTom FivezFilip MoermanIngel K DemedtsNicolas DaubyNicolas De SchryverElke GovaertsStefaan J VandecasteeleJohan Van LaethemSebastien AnguilleJeroen van der HilstBenoit MissetHans SlabbynckXavier WitteboleFabienne LiénartCatherine LegrandMarc BuyseDieter StevensFre BautersLeen SeysHelena Catharine AegerterUrsula SmoleVictor BosteelsLevi HosteLeslie NaesensFilomeen HaerynckLinos VandekerckhovePieter DepuydtEva Van BraeckelSylvie RotteyIsabelle PeeneCatherine Van Der StraetenFrank HulstaertBart Lambrecht

A1 Journal Article in LANCET RESPIRATORY MEDICINE

Immune monitoring in melanoma and urothelial cancer patients treated with anti-PD-1 immunotherapy and SBRT discloses tumor specific immune signatures

Annabel MeiresonSimon TavernierSofie Van GassenNora SundahlAnnelies DemeyerMathieu SpaasVibeke KruseLiesbeth FerdinandeJo Van DorpeBenjamin HennartDelphine AllorgeFilomeen HaerynckKarel DecaesteckerSylvie RotteyYvan SaeysPiet OstLieve Brochez

A1 Journal Article in CANCERS

Integration of genomics and transcriptomics allows the identification of rare DNA damage defects in PID patients with a cancer predisposition

Lynn BackersBram PartonMattias Van HeetveldeMarieke De BruyneKim De LeeneerSimon TavernierAnne VralFilomeen HaerynckKathleen Claes

Intestinal cDC1 drive cross-tolerance to epithelial-derived antigen via induction of FoxP3(+) CD8(+) T-regs

Thorsten JoerisCristina Gomez-CasadoPetra HolmkvistSimon TavernierAaron Silva-SanchezLuisa KlotzTroy D. RandallAllan M. MowatKnut KotarskyBernard MalissenWilliam W. Agace

A1 Journal Article in SCIENCE IMMUNOLOGY

Missing heritability in Bloom syndrome : First report of a deep-intronic variant leading to pseudo-exon activation in the BLM gene

Lynn BackersBram PartonMarieke De BruyneSimon TavernierKris Van Den BogaertBart LambrechtFilomeen HaerynckKathleen Claes

Missing heritability in Bloom syndrome : first report of a deep intronic variant leading to pseudo‐exon activation in the BLM gene

Lynn BackersBram PartonMarieke De BruyneSimon TavernierKris Van Den BogaertBart LambrechtFilomeen HaerynckKathleen Claes

A1 Journal Article in CLINICAL GENETICS

TIM3+ TRBV11-2 T cells and IFNγ signature in patrolling monocytes and CD16+ NK cells delineate MIS-C

Levi HosteLisa RoelsLeslie NaesensVictor BosteelsStijn VanheeSam DupontCedric BosteelsRobin BrowaeysNiels VandammeKevin VerstaenJana RoelsKarel Van DammeBastiaan MaesElisabeth De LeeuwJozefien DeclercqHelena Catharine AegerterLeen SeysUrsula SmoleSofie De PrijckManon VanheerswynghelsKarlien ClaesVeronique DebackerGert Van IsterdaelLynn BackersKathleen ClaesPaul BastardEmmanuelle JouanguyShen-Ying ZhangGilles MetsJoke DehoorneKristof VandekerckhovePetra SchelstraeteJef WillemsPatrick StordeurSophie JanssensRudi BeyaertYvan SaeysJean-Laurent CasanovaBart LambrechtFilomeen HaerynckSimon Tavernier

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

X-linked recessive TLR7 deficiency in ~1% of men under 60 years old with life-threatening COVID-19

Takaki AsanoBertrand BoissonFanny OnodiDaniela MatuozzoMarcela Moncada-VelezMajistor Raj Luxman Maglorius RenkilarajPeng ZhangLaurent MeertensAlexandre BolzeMarie MaternaSarantis KorniotisAdrian GervaisEstelle TalouarnBenedetta BigioYoann SeeleuthnerKaya BilguvarYu ZhangAnna-Lena NeehusMasato OgishiSimon J. PelhamTom Le VoyerJérémie RosainQuentin PhilippotPere Soler-PalacínRoger ColobranAndrea Martin-NaldaJacques G. RivièreYacine Tandjaoui-LambiotteKhalil ChaïbiMohammad ShahrooeiIlad Alavi DarazamNasrin Alipour OlyaeiDavood MansouriNevin HatipoğluFigen PalabiyikTayfun OzcelikGiuseppe NovelliAntonio NovelliGiorgio CasariAlessandro AiutiPaola CarreraSimone BondesanFederica BarzaghiPatrizia Rovere-QueriniCristina TresoldiJose Luis FrancoJulian RojasLuis Felipe ReyesIngrid G. BustosAndres Augusto AriasGuillaume MorelleChristèle KyhengJesús TroyaLaura Planas-SerraAgatha SchlüterMarta GutAurora PujolLuis M. AllendeCarlos Rodriguez-GallegoCarlos FloresOscar Cabrera-MaranteDaniel E. PleguezueloRebeca Pérez de DiegoSevgi KelesGokhan AytekinOzge Metin AkcanYenan T. BrycesonPeter BergmanPetter BrodinDaniel SmoleC. I. Edvard SmithAnna-Carin NorlinTessa M. CampbellLaura E. CovillLennart HammarströmQiang Pan-HammarströmHassan AbolhassaniShrikant ManeNico MarrManar AtaFatima Al AliTaushif KhanAndrás N. SpaanClifton L. DalgardPaolo BonfantiAndrea BiondiSarah TubianaCharles BurdetRobert NussbaumAmanda Kahn-KirbyAndrew L. SnowJacinta BustamanteAnne PuelStéphanie Boisson-DupuisShen-Ying ZhangVivien BéziatRichard P. LiftonPaul BastardLuigi D. NotarangeloLaurent AbelHelen C. SuEmmanuelle JouanguyAli AmaraVassili SoumelisAurélie CobatQian ZhangJean-Laurent CasanovaFilomeen HaerynckSimon TavernierBart LambrechtEva Van BraeckelCedric BosteelsLevi HosteEric HosteFre BautersJozefien De ClercqLeslie Naesenson behalf of COVID Human Genetic Efforton behalf of COVID Clinicians

A1 Journal Article in SCIENCE IMMUNOLOGY

‘Nieuwe heren, nieuwe wetten’ : identificatie van een nieuw pediatrisch inflammatoir syndroom in het midden van de SARS-CoV-2-pandemie

Levi HosteSimon TavernierFilomeen Haerynck

A4 Journal Article in PERCENTIEL (NEDERLANDSE ED.)

2020

Case report : convalescent plasma, a targeted therapy for patients with CVID and severe COVID-19

Karel Van DammeSimon TavernierNele Van RoyElisabeth De LeeuwJozefien DeclercqCedric BosteelsBastiaan MaesMarieke De BruyneDelfien BogaertVictor BosteelsLevi HosteLeslie NaesensP MaesA GrifoniD WeiskopfA SettePieter DepuydtEva Van BraeckelFilomeen HaerynckBart Lambrecht

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Cytokine profiling by multiplex immunoassay as a valuable tool for diagnosis and monitoring patients with autoinflammatory disorders

Levi HosteJo DehoornePeggy JacquesSteven CallensJeroen van der HilstVito SabatoBenson OgunjimiSimon TavernierFilomeen Haerynck

Dominant-negative mutations in human IL6ST underlie hyper-IgE syndrome

Vivien BéziatSimon TavernierYin-Huai ChenCindy S. MaMarie MaternaArian LaurenceJens StaalDominik AschenbrennerLisa RoelsLisa WorleyKathleen ClaesLisa GartnerLisa A. KohnMarieke De BruyneKlaus Schmitz-AbeLouis-Marie CharbonnierSevgi KelesJustine NammourNatasha VladikineMajistor Raj Luxman Maglorius RenkilarajYoann SeeleuthnerMélanie MigaudJérémie RosainMohamed JeljeliBertrand BoissonEva Van BraeckelJill A. RosenfeldHongzheng DaiLindsay C. BurrageDavid R. MurdockBart LambrechtVéronique Avettand-FenoelTiphanie P. VogelCharles R. EstherSule HaskologluFigen DoguPeter CiznarDavid BoutboulMarie Ouachée-ChardinJean AmouretteMarie-Noëlle LebrasClément GauvainColas TcherakianAydan IkinciogullariRudi BeyaertLaurent AbelJoshua D. MilnerBodo GrimbacherLouis-Jean CoudercManish J. ButteAlexandra F. FreemanÉmilie CatherinotClaire FieschiTalal A. ChatilaStuart G. TangyeHolm H. UhligFilomeen HaerynckJean-Laurent CasanovaAnne Puel[missing] Undiagnosed Diseases Network

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

First patient with bloom syndrome caused by a deep intronic variant leading to pseudoexon activation

Lynn BackersBram PartonStephanie VermeulenMarieke De BruyneSimon TavernierKris Van Den BogaertAnne VralAns BaeyensFilomeen HaerynckBart LambrechtKathleen Claes

First patient with bloom syndrome caused by a deep intronic variant leading to pseudoexon activation

Lynn BackersBram PartonStephanie VermeulenMarieke De BruyneKris Van Den BogaertAnne VralAns BaeyensSimon TavernierFilomeen HaerynckKathleen Claes

GATA2 deficiency and haematopoietic stem cell transplantation : challenges for the clinical practitioner

Delfien BogaertGenevieve LaureysLeslie NaesensDominiek MazureMarieke De BruyneAmy P. HsuMaria Bordon Cueto De BraemErik WoutersSimon TavernierBart LambrechtElfride De BaereFilomeen HaerynckTessa Kerre

A1 Journal Article in BRITISH JOURNAL OF HAEMATOLOGY

Inborn errors of type I IFN immunity in patients with life-threatening COVID-19

Qian ZhangPaul BastardZhiyong LiuJérémie Le PenMarcela Moncada-VelezJie ChenMasato OgishiIra K. D. SabliStephanie HodeibCecilia KorolJérémie RosainKaya BilguvarJunqiang YeAlexandre BolzeBenedetta BigioRui YangAndrés Augusto AriasQinhua ZhouYu ZhangFanny OnodiSarantis KorniotisLéa KarpfQuentin PhilippotMarwa ChbihiLucie Bonnet-MadinKarim DorghamNikaïa SmithWilliam M. SchneiderBrandon S. RazookyHans-Heinrich HoffmannEleftherios MichailidisLeen MoensJi Eun HanLazaro LorenzoLucy BizienPhilip MeadeAnna-Lena NeehusAileen Camille UgurbilAurélien CorneauGaspard KernerPeng ZhangFranck RapaportYoann SeeleuthnerJeremy ManryCecile MassonYohann SchmittAgatha SchlüterTom Le VoyerTaushif KhanJuan LiJacques FellayLucie RousselMohammad ShahrooeiMohammed F. AlosaimiDavood MansouriHaya Al-SaudFahd Al-MullaFeras AlmourfiSaleh Zaid Al-MuhsenFahad AlsohimeSaeed Al TurkiRana HasanatoDiederik van de BeekAndrea BiondiLaura Rachele BettiniMariella D’AngioPaolo BonfantiLuisa ImbertiAlessandra SottiniSimone PagheraEugenia Quiros-RoldanCamillo RossiAndrew J. OlerMiranda F. TompkinsCamille AlbaIsabelle VandernootJean-Christophe GoffardGuillaume SmitsIsabelle MigeotteFilomeen HaerynckPere Soler-PalacinAndrea Martin-NaldaRoger ColobranPierre-Emmanuel MorangeSevgi KelesFatma ÇölkesenTayfun OzcelikKadriye Kart YasarSevtap SenogluŞemsi Nur KarabelaCarlos Rodríguez GallegoGiuseppe NovelliSami HraiechYacine Tandjaoui-LambiotteXavier DuvalCédric LaouénanAndrew L. SnowClifton L. DalgardJoshua MilnerDonald C. VinhTrine H. MogensenNico MarrAndrás N. SpaanBertrand BoissonStéphanie Boisson-DupuisJacinta BustamanteAnne PuelMichael CiancanelliIsabelle MeytsTom ManiatisVassili SoumelisAli AmaraMichel NussenzweigAdolfo García-SastreFlorian KrammerAurora PujolDarragh DuffyRichard LiftonShen-Ying ZhangGuy GorochovVivien BéziatEmmanuelle JouanguyVanessa Sancho-ShimizuCharles M. RiceLaurent AbelLuigi D. NotarangeloAurélie CobatHelen C. SuJean-Laurent CasanovaCedric BosteelsLevi HosteEric HosteLeslie NaesensSimon Tavernier[missing] COVID-STORM Clinicians[missing] COVID CliniciansEva Van Braeckel[missing] Imagine COVID Group[missing] French COVID Cohort Study Group[missing] CoV-Contact Cohort[missing] Amsterdam UMC Covid-19[missing] Biobank[missing] COVID Human Genetic Effort[missing] NIAID-USUHS[missing] TAGC COVID Immunity Group

A1 Journal Article in SCIENCE

Integrin expression changes on the T cells subsets influence the response to vedolizumab in inflammatory bowel disease patients

Cara De GalanSophie Van WeldenSimon BosSimon TavernierTriana Lobatón OrtegaGerard GonzalesWouter Van MoerkerckeBeatrijs StrubbeHarald PeetersElisabeth MackenMartine De VosDebby LaukensPieter Hindryckx

Missing heritability in Bloom syndrome : first report of a deep-intronic variant leading to pseudo-exon activation in the BLM gene

Lynn BackersBram PartonMarieke De BruyneSimon TavernierKris Van Den BogaertBart LambrechtFilomeen HaerynckKathleen Claes

cDNA and targeted RNA sequencing to unravel hidden genetic defects in PID patients with only one-disease related variant in genes with recessive inheritance

Lynn BackersMarieke De BruyneSimon TavernierFilomeen HaerynckKathleen Claes

2019

A computational pipeline for the diagnosis of CVID patients

Annelies EmmaneelDelfien BogaertSofie Van GassenSimon TavernierMelissa DullaersFilomeen HaerynckYvan Saeys

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

A human immune dysregulation syndrome characterized by severe hyperinflammation with a homozygous nonsense Roquin-1 mutation

Simon TavernierV AthanasopoulosPatrick VerlooG BehrensJens StaalDelfien BogaertLeslie NaesensMarieke De BruyneSofie Van GassenEef ParthoensJ EllyardJ CappelloLX MorrisHanne Van GorpGert Van IsterdaelYvan SaeysMohamed LamkanfiPetra SchelstraeteJo DehoorneMaria Bordon Cueto De BraemRudy Van CosterBart LambrechtBjörn MentenRudi BeyaertCG VinuesaV HeissmeyerMelissa DullaersFilomeen Haerynck

A1 Journal Article in NATURE COMMUNICATIONS

GATA2 deficiency and hematopoietic stem cell transplantation : challenges for the clinical practitioner

Delfien BogaertLeslie NaesensGenevieve LaureysMaria Bordon Cueto De BraemErik WoutersSimon TavernierBart LambrechtFilomeen HaerynckTessa Kerre

Homozygous NLRP1 gain-of-function mutation in siblings with a syndromic form of recurrent respiratory papillomatosis

Scott B DrutmanFilomeen HaerynckFranklin L ZhongDavid HumNicholas J HernandezSerkan BelkayaFranck RapaportSarah Jill de JongDavid CreytensSimon TavernierKatrien BonteSofie De SchepperJutte van der Werff ten BoschLazaro Lorenzo-DiazAndy WullaertXavier BossuytGérard OrthVincent R BonaguraVivien BéziatLaurent AbelEmmanuelle JouanguyBruno ReversadeJean Laurent-Casanova

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Integrin expression changes on the T cell subsets influence the response to vedolizumab in inflammatory bowel disease patients

Cara De GalanSophie Van WeldenSimon BosSimon TavernierTriana Lobatón OrtegaGerard GonzalesWouter Van MoerkerckeBeatrijs StrubbeHarald PeetersElisabeth MackenMartine De VosDebby LaukensPieter Hindryckx

Metabolic and innate immune cues merge into a specific inflammatory response via the UPR

Denis A MogilenkoJoel T HaasLaurent L’hommeSébastien FleurySandrine QuemenerMatthieu LevavasseurCoralie BecquartJulien WartelleAlexandra BogomolovaLaurent PineauOlivier Molendi-CosteSteve LancelHélène DehondtCeline GheeraertAurelie MelchiorCédric DewasArtemii NikitinSamuel PicNabil RabhiJean-Sébastien AnnicotteSeiichi OyadomariTalia Velasco-HernandezJörg CammengaMarc ForetzBenoit ViolletMilica VukovicArnaud VillacrecesKamil KrancPeter CarmelietGuillemette MarotAlexis BoulterSimon TavernierLuciana BerodMaria P LonghiChristophe PagetSophie JanssensDelphine Staumont-SalléEzra AksoyBart StaelsDavid Dombrowicz

A1 Journal Article in CELL

Pitfalls in diagnosing complement factor I deficiencies : from clinical phenotype to laboratory diagnosis

Leslie NaesensJulie SmetSimon TavernierStijn LambrechtTessa KerreJohan Van de WalleLubka RoumeninaPatrick StordeurFilomeen Haerynck

The ubiquitin-editing enzyme A20 controls NK cell homeostasis through regulation of mTOR activity and TNF

Jessica VettersMary van HeldenSigrid WahlenSimon TavernierArne MartensFarzaneh FayazpourKarl VergoteManon VanheerswynghelsKim DeswarteJustine Van MoorleghemSofie De PrijckNozomi TakahashiPeter VandenabeeleLouis BoonGeert van LooEric VivierBart LambrechtSophie Janssens

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

cDNA and targeted RNA sequencing to unravel hidden genetic defects in PID patients with only one-disease related variant in genes with recessive inheritance

Lynn BackersMarieke De BruyneSimon TavernierFilomeen HaerynckKathleen Claes

2018

A CARD9 founder mutation disrupts NF-κB signaling by inhibiting BCL10 and MALT1 recruitment and signalosome formation

Marieke De BruyneLevi HosteDelfien BogaertLien Van den BosscheSimon TavernierEef ParthoensMélanie MigaudDeborah KonopnickiJean Cyr YombiBart LambrechtSabine Van daeleAna Alves de MedeirosLieve BrochezRudi BeyaertElfride De BaereAnne PuelJean-Laurent CasanovaJean-Christophe GoffardSavvas SavvidesFilomeen HaerynckJens StaalMelissa Dullaers

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

A novel LPS-responsive beige-like anchor protein (LRBA) mutation presents with normal cytotoxic T lymphocyte-associated protein 4 (CTLA-4) and overactive TH17 immunity

Marieke De BruyneDelfien BogaertKoen VenkenLien Van den BosscheCarolien BonroyLisa RoelsSimon TavernierEls van de VijverAnn DriessenMarielle van GijnLaura Gámez-DiazDirk ElewautBodo GrimbacherFilomeen HaerynckNicolette MoesMelissa Dullaers

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Stabilization of cytokine mRNAs in iNKT cells requires the serine-threonine kinase IRE1alpha

Srinath GovindarajanDjoere GaublommeRenée Van der CruyssenEveline VerheugenSofie Van GassenYvan SaeysSimon TavernierTakao IwawakiYehudi BlochSavvas SavvidesBart LambrechtSophie JanssensDirk ElewautMichael Drennan

A1 Journal Article in NATURE COMMUNICATIONS

The unfolded protein response in the immune cell development : putting the caretaker in the driving seat

Simon TavernierBart LambrechtSophie Janssens

A1 Journal Article in CURRENT TOPICS IN MICROBIOLOGY AND IMMUNOLOGY

2017

Dendritic cells under stress : on the role of the unfolded protein response and hypoxia signaling

Simon TavernierSophie JanssensBart Lambrecht

Haematopoietic prolyl hydroxylase-1 deficiency promotes M2 macrophage polarization and is both necessary and sufficient to protect against experimental colitis

Sophie Van WeldenMartine De VosBen WielockxSimon TavernierMelissa DullaersSara NeytBenedicte DescampsLindsey DevisscherSarah DevrieseLien Van den BosscheTom HolvoetAnn BaeyensCarmen CorrealeSilvia D'AlessioChristian VanhoveFilip De VosBruno VerhasseltGeorg BreierBart LambrechtSophie JanssensPeter CarmelietSilvio DaneseDirk ElewautDebby LaukensPieter Hindryckx

A1 Journal Article in JOURNAL OF PATHOLOGY

Opposing regulation and roles for PHD3 in lung dendritic cells and alveolar macrophages

Simon TavernierNele VanlangenakkerJessica VettersPeter CarmelietSophie JanssensBart Lambrecht

A1 Journal Article in JOURNAL OF LEUKOCYTE BIOLOGY

Regulated IRE1-dependent mRNA decay sets the threshold for dendritic cell survival

Simon TavernierFabiola OsorioLana VandersarrenJessica VettersNele VanlangenakkerGert Van IsterdaelKarl VergoteRiet De RyckeEef ParthoensLianne van de LaarTakao IwawakiJuan R Del ValleChih-Chi Andrew HuBart LambrechtSophie Janssens

A1 Journal Article in NATURE CELL BIOLOGY

2016

Isolation of conventional dendritic cells from mouse lungs

Lianne van de LaarMartin GuilliamsSimon Tavernier

Bookchapter in Dendritic cell protocols

Unsupervised high-dimensional analysis aligns dendritic cells across tissues and species

Martin GuilliamsCharles-Antoine DutertreCharlotte ScottNaomi McGovernDorine SichienSvetoslav ChakarovSofie Van GassenJinmiao ChenMichael PoidingerSofie De PrijckSimon TavernierIvy LowSergio Erdal IracCitra Nurfarah MattarHermi Rizal SumatohGillian Hui Ling LowTam John Kit ChungDedrick Kok Hong ChanKer Kan TanTony Lim Kiat HonEven FossumBjarne BogenMahesh ChoolaniJerry Kok Yen ChanAnis LarbiHervé LucheSandrine HenriYvan SaeysEvan William NewellBart LambrechtBernard MalissenFlorent Ginhoux

A1 Journal Article in IMMUNITY

2014

The unfolded-protein-response sensor IRE-1α regulates the function of CD8α⁺ dendritic cells

Fabiola OsorioSimon TavernierEik HoffmannYvan SaeysLiesbet MartensJessica VettersIris DelrueRiet De RyckeEef ParthoensPhilippe PouliotTakao IwawakiSophie JanssensBart Lambrecht

A1 Journal Article in NATURE IMMUNOLOGY

2010

Geneesmiddelen en ontwikkelingslanden

REBECCA STAELSimon TavernierFilip ViaeneML DelfosseMarcus BogaertJan De Maeseneer

A2 Journal Article in TIJDSCHRIFT VOOR GENEESKUNDE