Research Explorer

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Researcher

Sigrid Verhasselt

Publications & Research Data

Awards & Distinctions

15 Results

2018

Medicinal chemistry and use of myosin II inhibitor (S)-blebbistatin and its derivatives

Bart RomanSigrid VerhasseltChristian Stevens

A1 Journal Article in JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of C-ring-modified blebbistatin derivatives and evaluation of their myosin II ATPase inhibitory potency

Bart RomanSigrid VerhasseltChristophe MangodtOlivier De WeverChristian Stevens

A1 Journal Article in BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

2017

Development of novel blebbistatin derivatives in the quest for improved non-muscle myosin II inhibitors

Sigrid VerhasseltChristian StevensBart RomanMarc Bracke

Discovery of (S)-3′-hydroxyblebbistatin and (S)-3′-aminoblebbistatin : polar myosin II inhibitors with superior research tool properties

Sigrid VerhasseltBart RomanOlivier De WeverKristof Van HeckeRik Van DeunMarc BrackeChristian Stevens

A1 Journal Article in ORGANIC & BIOMOLECULAR CHEMISTRY

Improved synthesis and comparative analysis of the tool properties of new and existing D-ring modified (S)-blebbistatin analogs

Sigrid VerhasseltBart RomanMarc BrackeChristian Stevens

A1 Journal Article in EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Insights into the myosin II inhibitory potency of A-ring-modified (S)-blebbistatin analogs

Sigrid VerhasseltChristian StevensTom Van den broeckeMarc BrackeBart Roman

A1 Journal Article in BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

2016

Biology oriented synthesis aiming at physiological activity

Christian StevensSigrid VerhasseltMelissa Van OvertveldtBart RomanThomas Heugebaert

Discovery of anti-invasive tools and leads for the study and treatment of metastatic cancer : two case studies

Bart RomanSigrid VerhasseltMarc BrackeChristian Stevens

Discovery of novel nonmuscle myosin II inhibitors as antimetastatic therapeutics leads and chemical tools

Sigrid VerhasseltMarc BrackeChristian StevensBart Roman

Discovery of novel nonmuscle myosin II inhibitors as chemical tools and antimetastatic therapeutics leads

Sigrid VerhasseltMarc BrackeChristian StevensBart Roman

2015

Further studies on anti-invasive chemotypes: an excursion from chalcones to curcuminoids

Bart RomanTine De RyckSigrid VerhasseltMarc BrackeChristian Stevens

A1 Journal Article in BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

2014

Feruloyl benzotriazole and Weinreb amide as bioinspired building blocks: a reactivity study

Bart RomanJean-Christophe MonbaliuLaurens De CoenSigrid VerhasseltChristian Stevens

Feruloylbenzotriazole and Weinreb amide as bioinspired building blocks: a reactivity study towards O-, N-, S-, and C- nucleophiles

Bart RomanJean-Christophe MonbaliuLaurens De CoenSigrid VerhasseltBart SchuddinckEvelien Van HoeylandtChristian Stevens

A1 Journal Article in EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

On the quest for new anti-invasive agents: from the discovery of 4-fluoro-3',4','5'-trimethoxychalcone to its initial validation in an in vivo metastasis model

Bart RomanTine De RyckSigrid VerhasseltAlan KatritzkyMarc BrackeChristian Stevens

2013

Feruloyl benzotriazole and Weinreb amide as bioinspired building blocks: a reactivity study

Bart RomanJean-Christophe MonbaliuLaurens De CoenSigrid VerhasseltChristian Stevens