Research Explorer

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Researcher

Sieglinde De Cae

Publications & Research Data

Awards & Distinctions

5 Results

2026

High-throughput quantification of spike protein expression by LC–MS for mRNA-LNP evaluation and immune response profiling

Ruben AlmeyKevin MwangiAmélie De MaesschalckThomas EhouarneSieglinde De CaePathmanaban RamasamyMarijn Van HulleIne LentackerBert SchepensDieter Deforce et al.

A1 Journal Article in ANALYTICAL CHEMISTRY

2025

Identification and characterization of heptad repeat 2 as a target for neutralizing antibodies on the SARS coronavirus spike

Sieglinde De CaeXavier SaelensBert Schepens

Ultrapotent SARS coronavirus-neutralizing single-domain antibodies that clamp the spike at its base

Sieglinde De CaeInge Van MolleLoes van SchieSophie R. ShoemakerJulie DeckersNincy DebeufSahine LameireWim NerinckxKenny RooseDaria Fijalkowska et al.

A1 Journal Article in NATURE COMMUNICATIONS

2024

Integrating artificial intelligence-based epitope prediction in a SARS-CoV-2 antibody discovery pipeline : caution is warranted

Delphine Diana AcarWojciech WitkowskiMagdalena WejdaRuifang WeiTim DesmetBert SchepensSieglinde De CaeKoen SedeynHannah EeckhautDaria Fijalkowska et al.

A1 Journal Article in EBIOMEDICINE

2021

An affinity-enhanced, broadly neutralizing heavy chain-only antibody protects against SARS-CoV-2 infection in animal models

Bert SchepensLoes van SchieWim NerinckxKenny RooseWander Van BreedamDaria FijalkowskaSimon DevosWannes WeytsSieglinde De CaeSandrine Vanmarcke et al.

A1 Journal Article in SCIENCE TRANSLATIONAL MEDICINE